Dora Koller, Eleni Friligkou, Brendan Stiltner, Gita A Pathak, Solveig Løkhammer, Daniel F Levey, Hang Zhou, Alexander S Hatoum, Joseph D Deak, Rachel L Kember, Jorien L Treur, Henry R Kranzler, Emma C Johnson, Murray B Stein, Joel Gelernter, Renato Polimanti
Individuals suffering from chronic pain develop substance use disorders (SUDs) more often than others. Understanding the shared genetic influences underlying the comorbidity between chronic pain and SUDs will lead to a greater understanding of their biology. Genome-wide association statistics were obtained from the UK Biobank for multisite chronic pain (MCP, Neffective = 387,649) and from the Million Veteran Program and the Psychiatric Genomics Consortium meta-analyses for alcohol use disorder (AUD, Neffective = 296,974), cannabis use disorder (CanUD, Neffective = 161,053), opioid use disorder (OUD, Neffective = 57,120), and problematic tobacco use (PTU, Neffective = 270,120)...
February 15, 2024: Molecular Psychiatry