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https://www.readbyqxmd.com/read/27822048/analysis-of-treatment-patterns-and-persistence-on-branded-and-generic-medications-in-major-depressive-disorder-using-retrospective-claims-data
#1
Caitlyn T Solem, Ahmed Shelbaya, Yin Wan, Chinmay G Deshpande, Jose Alvir, Elizabeth Pappadopulos
BACKGROUND: In major depressive disorder (MDD), treatment persistence is critical to optimize symptom remission, functional recovery, and health care costs. Desvenlafaxine tends to have fewer drug interactions and better tolerability than other MDD drugs; however, its use has not been assessed in the real world. OBJECTIVE: The aim of the present study is to compare medication persistence and concomitant MDD drug use with branded desvenlafaxine (Pristiq(®)) compared with antidepressant drug groups classified as 1) branded selective serotonin reuptake inhibitors (SSRIs; ie, escitalopram [Lexapro™]) and selective serotonin-norepinephrine reuptake inhibitors (SNRIs; ie, venlafaxine [Effexor(®)], duloxetine [Cymbalta(®)]) and 2) generic SSRIs/SNRIs (ie, escitalopram, citalopram, venlafaxine, fluvoxamine, fluoxetine, sertraline, paroxetine, and duloxetine)...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/26091569/in-vitro-solubility-dissolution-and-permeability-studies-combined-with-semi-mechanistic-modeling-to-investigate-the-intestinal-absorption-of-desvenlafaxine-from-an-immediate-and-extended-release-formulation
#2
F Franek, A Jarlfors, F Larsen, P Holm, B Steffansen
Desvenlafaxine is a biopharmaceutics classification system (BCS) class 1 (high solubility, high permeability) and biopharmaceutical drug disposition classification system (BDDCS) class 3, (high solubility, poor metabolism; implying low permeability) compound. Thus the rate-limiting step for desvenlafaxine absorption (i.e. intestinal dissolution or permeation) is not fully clarified. The aim of this study was to investigate whether dissolution and/or intestinal permeability rate-limit desvenlafaxine absorption from an immediate-release formulation (IRF) and Pristiq(®), an extended release formulation (ERF)...
September 18, 2015: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/21757637/inhibitory-effects-of-desvenlafaxine-on-gastric-slow-waves-antral-contractions-and-gastric-accommodation-mediated-via-the-sympathetic-mechanism-in-dogs
#3
Fei Dai, Yong Lei, Jiande D Z Chen
Desvenlafaxine succinate (DVS; Pristiq) is a new antidepressant, serotonin-norepinephrine reuptake inhibitor. Antidepressants have been widely used for the treatment of functional gastrointestinal disorders. Possible roles of DVS on gastrointestinal motility have not been studied. The aim of this study was to investigate the effects of DVS on gastric slow waves (GSW), antral contractions, and gastric accommodation in dogs. Fifteen healthy dogs implanted with gastric serosal electrodes and a gastric cannula were studied in four separate sessions: control, DVS (50 mg), propranolol (1 mg·kg(-1)·h(-1)), and propranolol + DVS...
October 2011: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/19698900/desvenlafaxine-a-new-serotonin-norepinephrine-reuptake-inhibitor-for-the-treatment-of-adults-with-major-depressive-disorder
#4
REVIEW
Richard Perry, Manouchkathe Cassagnol
BACKGROUND: Desvenlafaxine succinate, a serotonin-norepinephrine reuptake inhibitor (SNRI), was approved by the US Food and Drug Administration (FDA) in February 2008 for the treatment of adult patients with major depressive disorder (MDD). Desvenlafaxine is the third SNRI approved by the FDA for this indication. OBJECTIVE: This article reviews the available information for desvenlafaxine, focusing on its pharmacodynamics, pharmacokinetics, clinical efficacy, and safety profile...
June 2009: Clinical Therapeutics
https://www.readbyqxmd.com/read/19155879/drug-approvals-08-in-review-desvenlafaxine-pristiq
#5
Gary Laustsen, Fernando Carrillo, Jessica Johnson, Cynthia Smith
No abstract text is available yet for this article.
February 2009: Nurse Practitioner
https://www.readbyqxmd.com/read/18698015/desvenlafaxine-another-me-too-drug
#6
REVIEW
Michael A Sopko, Megan J Ehret, Marina Grgas
OBJECTIVE: To compare desvenlafaxine with its parent drug, venlafaxine, to determine the usefulness of this new medication. DATA SOURCES: Information was obtained through a MEDLINE search (1966-June 2008) and from published abstracts. Search terms included desvenlafaxine, O-desmethylvenlafaxine, Pristiq, major depressive disorder, and venlafaxine. STUDY SELECTION AND DATA EXTRACTION: All English-language studies and abstracts pertaining to desvenlafaxine and venlafaxine were considered for inclusion...
October 2008: Annals of Pharmacotherapy
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