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https://www.readbyqxmd.com/read/28927117/salvia-miltiorrhiza-extract-inhibits-tpa-induced-mmp-9-expression-and-invasion-through-the-mapk-ap-1-signaling-pathway-in-human-breast-cancer-mcf-7-cells
#1
Jeong-Mi Kim, Eun-Mi Noh, Hyun-Kyung Song, Minok Lee, Soo Ho Lee, Sueng Hyuk Park, Chan-Keun Ahn, Guem-San Lee, Eui-Baek Byun, Beom-Su Jang, Kang-Beom Kwon, Young-Rae Lee
Cancer cell invasion is crucial for metastasis. A major factor in the capacity of cancer cell invasion is the activation of matrix metalloproteinase-9 (MMP-9), which degrades the extracellular matrix. Salvia miltiorrhiza has been used as a promotion for blood circulation to remove blood stasis. Numerous previous studies have demonstrated that S. miltiorrhiza extracts (SME) decrease lipid levels and inhibit inflammation. However, the mechanism behind the effect of SME on breast cancer invasion has not been identified...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28926922/potential-use-and-the-energy-conversion-efficiency-analysis-of-fermentation-effluents-from-photo-and-dark-fermentative-bio-hydrogen-production
#2
Zhiping Zhang, Yameng Li, Huan Zhang, Chao He, Quanguo Zhang
Effluent of bio-hydrogen production system also can be adopted to produce methane for further fermentation, cogeneration of hydrogen and methane will significantly improve the energy conversion efficiency. Platanus Orientalis leaves were taken as the raw material for photo- and dark-fermentation bio-hydrogen production. The resulting concentrations of acetic, butyric, and propionic acids and ethanol in the photo- and dark-fermentation effluents were 2966mg/L and 624mg/L, 422mg/L and 1624mg/L, 1365mg/L and 558mg/L, and 866mg/L and 1352mg/L, respectively...
September 8, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28926907/research-on-the-quick-and-efficient-recovery-of-1-allyl-3-methylimidazolium-chloride-after-biomass-pretreatment-with-ionic-liquid-aqueous-alcohol-system
#3
Xiaocong Liang, Yan Fu, Jie Chang
Membrane-based methodology electrodialysis (ED) was employed for the quick and efficient recovery of ionic liquid AmimCl from the aqueous solutions after biomass pretreatment with AmimCl-aqueous methanol/ethanol systems. IL recovery performance was relatively stable as the variation of IL-alcohol systems employed in the pretreatment process. IL recovery ratio (R) of 66%-71%, IL recovery performance of specific energy consumption (Sp) of 429-467g/kwh and IL transport rate (Tr) of 5.3-8.2g/(m(2)min) were obtained by single ED treatment...
August 24, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28926900/-the-combination-of-percutaneous-iohexol-ethanol-injection-with-radiofrequency-ablation-for-the-treatment-of-primary-liver-cancer-in-high-risk-locations
#4
W Sun, X Y Ding, J L Chen, W D Li, X Y Wang, X D Guo, Y J Shen, S S Sun
Objective: To investigate the safety and efficacy of radiofrequency ablation (RFA) with percutaneous iohexol-ethanol injection (PIEI), compared with RFA plus transcatheter arterial chemoembolization (TACE) for patients with primary liver cancer(PLC)in high-risk locations. Methods: From January 2012 to December 2014, 54 patients with PLC in high-risk locations were enrolled. They were divided into Group A (RFA combined with PIEI) and Group B (RFA plus TACE). The efficacy and adverse events were assessed. Results: 54 patients had 74 lesions in high-risk locations...
September 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28926584/transcriptome-analysis-reveals-molecular-anthelmintic-effects-of-procyanidins-in-c-elegans
#5
Verena Spiegler, Andreas Hensel, Jochen Seggewiß, Milena Lubisch, Eva Liebau
Worldwide, more than 1 billion people are affected by infestations with soil-transmitted helminths and also in veterinary medicine helminthiases are a severe threat to livestock due to emerging resistances against the common anthelmintics. Proanthocyanidins have been increasingly investigated for their anthelmintic properties, however, except for an interaction with certain proteins of the nematodes, not much is known about their mode of action. To investigate the anthelmintic activity on a molecular level, a transcriptome analysis was performed in Caenorhabditis elegans after treatment with purified and fully characterized oligomeric procyanidins (OPC)...
2017: PloS One
https://www.readbyqxmd.com/read/28926512/orthosiphon-stamineus-misai-kucing-ameliorated-postmenopausal-osteoporosis-in-rat-model
#6
Rubiatul Adawiyah Bokhari, Seng Fong Lau, Suhaila Mohamed
OBJECTIVE: Orthosiphon stamineus (OS) or Misai Kucing (Java tea) is a popular herbal supplement from Southeast Asia for various metabolic, age-related diseases. This study investigated the potential use of OS leaf extracts to ameliorate osteoporosis in ovariectomized rats. METHODS: Fifty-six female Sprague-Dawley rats were randomly allocated into eight groups (n = 7): SHAM (healthy sham control); OVX (ovarietomized) nontreated rats (negative control); OVX + Remifemin (100 mg/kg body weight), and 2% green tea extract (positive controls); OVX + OS 50% ethanolic and aqueous extracts, both at either 150 or 300 mg/kg...
September 18, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28926343/the-impact-of-stress-on-social-behavior-in-adult-zebrafish-danio-rerio
#7
Shannon M Saszik, Conor M Smith
Stress has adverse effects on social behavior that is mediated by dopamine circuits in the midbrain. The purpose of this research is to examine the effect of chronic stress and dopamine signals on social behavior in zebrafish (Danio rerio). Chronic stress was induced chemically with low dosage of ethanol (0.25% for 5 days), and psychosocially with isolation (3-5 days) or overcrowding (5 days). Dopamine activity was decreased by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exposure. Social behavior was observed by introducing one treated zebrafish to a group of four control zebrafish and measuring the nearest neighbor distance (NND)...
September 18, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28926223/supramolecular-motors-on-graphite-surface-stabilized-by-charge-states-and-hydrogen-bonds
#8
Kai Sun, Ji-Yong Luo, Xin Zhang, Zhi-Jian Wu, Ying Wang, Hong-Kuan Yuan, Zu-Hong Xiong, Shao-Chun Li, Qi-Kun Xue, Jun-Zhong Wang
Molecular motors are nanoscale machines that convert external energies into controlled mechanical movements. In supramolecular motors, the rotator and stator are held together mechanically, and thus the rotation can be essentially barrier free when molecular conformation is negligible. However, nearly all the supramolecular motors appeared in solutions or host-guest complexes. Surface-mounted supramolecular motors have rarely been addressed, even though they are easily manipulated by external fields. Here we report a surface-mounted supramolecular motor assembled by charge states and hydrogen bonds...
September 19, 2017: ACS Nano
https://www.readbyqxmd.com/read/28926196/a-strategy-for-simultaneous-synthesis-of-methallyl-alcohol-and-diethyl-acetal-with-sn-%C3%AE
#9
Wenda Hu, Yan Wan, Lili Zhu, Xiaojie Cheng, Shaolong Wan, Jingdong Lin, Yong Wang
Herein we report a strategy to simultaneously produce two important chemicals namely Methallyl alcohol (Mol) and diethyl acetal (Dal) from methacrolein (Mal) in ethanol solvent at low temperature with the use of Beta zeolites modified by tin (Sn-β catalysts). All Sn-β catalysts were prepared by the solid-state ion-exchange (SSIE) method, wherein the calcination step was conducted in different gas atmospheres. The one pre-calcined in Ar (Sn-β-Ar) diminishes the number of extra-framework Sn species and instead enables more Sn species exchanged into the framework as isolated tetrahedral Sn (IV), thus enhancing the catalytic activity of Meerwein-Ponndorf-Verley (MPV) reaction...
September 19, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28925686/a-naphthalimide-based-fluorophore-for-soft-anionic-interface-monitoring
#10
Li Wang, Gang Wang, Congdi Shang, Rui Kang, Yu Fang
A naphthalimide-based low-molecular mass fluorophore (NA) was designed and synthesized by introducing an azetidine unit onto the aromatic ring of the compound as an electron-donating structure, and a hydrophilic (2-(2-aminoethylamino)ethanol) moiety into the 'N-imide site' of the core structure. UV-vis absorption and fluorescence measurements revealed that the fluorophore is soluble in water, and shows a fluorescent quantum yield of ~20% and lifetime of ~3.7 ns in the solvent within a wide pH range. Moreover, the fluorescence emission and anisotropy of the fluorophore as produced are both dependent upon the viscosity and polarity of the medium...
September 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28925280/can-acetic-acid-substitute-ethanol-for-the-reduction-of-cardiovascular-disease-risks
#11
Yunfan Shi, Yulin Wan, Kai Wang, Ying Zhang, Qiuyun Liu
No abstract text is available yet for this article.
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28925259/pinus-pinaster-knot-a-source-of-polyphenols-against-plasmopara-viticola
#12
Julien Gabaston, Tristan Richard, Stéphanie Cluzet, Antonio Palos Pinto, Marie-Cécile Dufour, Marie-France Coriocostet, Jean-Michel Merillon
Pine knot extract from Pinus pinaster by-products was characterized by UHPLC-DAD-MS and NMR. Fourteen polyphenols divided in four classes were identified as follows: lignans (nortrachelogenin, pinoresinol, matairesinol, isolariciresinol, secoisolariciresinol), flavonoids (pinocembrin, pinobanksin, dihydrokaempferol, taxifolin), stilbenes (pinosylvin, pinosylvin monomethyl ether, pterostilbene) and phenolic acids (caffeic acid, ferulic acid). The antifungal potential of pine knot extract was tested in vitro against Plasmopara viticola as well as the main compounds...
September 19, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28925146/-rapid-monitoring-five-components-of-ethanol-precipitation-process-of-shenzhiling-oral-solution-using-near-infrared-spectroscopy
#13
Tong-Tong Li, Tian Hu, Lei Nie, Li-Xuan Zang, Ying-Zi Zeng, Heng-Chang Zang
To develop a method for the rapid monitoring of five components during the alcohol precipitation process of Shenzhiling oral solution using near infrared spectroscopy(NIRS).The contents of five components detemined by high performance liquid chromatography(HPLC) were used as the reference values, and the NIRS based partial least square regression(PLSR) models were used to monitor the concentrations of paeoniflorin, albiflorin, liquiritin, cinnamic acid and glycyrrhizic acid during the alcohol precipitation process of Shenzhiling oral solution, which were optimized and verified through comparing of different spectral pre-processing and variables selection methods...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28924473/chlorhexidine-is-not-an-essential-component-in-alcohol-based-surgical-hand-preparation-a-comparative-study-of-two-handrubs-based-on-a-modified-en-12791-test-protocol
#14
Thomas-Jörg Hennig, Sebastian Werner, Kathrin Naujox, Andreas Arndt
BACKGROUND: Surgical hand preparation is an essential part of modern surgery. Both alcohol-based and antiseptic detergent-based hand preparation are recommended practices, with a trend towards use of alcohol based handrubs. However, discussion has arisen whether chlorhexidine is a required ingredient in highly efficacious alcohol-based formulations, in view of providing sustained antimicrobial efficacy. METHODS: One alcohol-only formulation (product A), containing ethanol and n-propanol, and one formulation containing a chlorhexidine-ethanol combination (product B) were directly compared with each other using a modified test protocol based on European standard EN 12791 (2016) with 25 volunteers...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28924451/phenotypic-landscape-of-non-conventional-yeast-species-for-different-stress-tolerance-traits-desirable-in-bioethanol-fermentation
#15
Vaskar Mukherjee, Dorota Radecka, Guido Aerts, Kevin J Verstrepen, Bart Lievens, Johan M Thevelein
BACKGROUND: Non-conventional yeasts present a huge, yet barely exploited, resource of yeast biodiversity for industrial applications. This presents a great opportunity to explore alternative ethanol-fermenting yeasts that are more adapted to some of the stress factors present in the harsh environmental conditions in second-generation (2G) bioethanol fermentation. Extremely tolerant yeast species are interesting candidates to investigate the underlying tolerance mechanisms and to identify genes that when transferred to existing industrial strains could help to design more stress-tolerant cell factories...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28923930/copper-nanoparticle-ensembles-for-selective-electroreduction-of-co2-to-c2-c3-products
#16
Dohyung Kim, Christopher S Kley, Yifan Li, Peidong Yang
Direct conversion of carbon dioxide to multicarbon products remains as a grand challenge in electrochemical CO2 reduction. Various forms of oxidized copper have been demonstrated as electrocatalysts that still require large overpotentials. Here, we show that an ensemble of Cu nanoparticles (NPs) enables selective formation of C2-C3 products at low overpotentials. Densely packed Cu NP ensembles underwent structural transformation during electrolysis into electrocatalytically active cube-like particles intermixed with smaller nanoparticles...
September 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28923781/low-dose-of-alcohol-attenuates-pro-atherosclerotic-activity-of-thrombin
#17
Masaaki Toda, Toshiaki Totoki, Chizu Nakamura, Taro Yasuma, Corina N D' Alessandro-Gabazza, Rumi Mifuji-Moroka, Kota Nishihama, Motoh Iwasa, Noriyuki Horiki, Esteban C Gabazza, Yoshiyuki Takei
BACKGROUND AND AIMS: Thrombin, the active enzyme of the coagulation system, plays a critical role in the pathogenesis of atherosclerosis. Vascular repair promoted by stromal cell-derived factor-1 is a protective process in atherosclerosis. Consumption of low amount of alcohol is believed to reduce the risk of atherosclerotic cardiovascular disease but the mechanism is unclear. This study evaluated whether alcohol can modulate the expression of stromal cell-derived factor-1 and the pro-atherosclerotic activity of thrombin...
September 5, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28923571/ophthalmic-administration-of-a-10-fold-lower-dose-of-conventional-nanoliposome-formulations-caused-levels-of-intraocular-pressure-similar-to-those-induced-by-marketed-eye-drops
#18
C M Arroyo, D Quinteros, M J Cózar-Bernal, S D Palma, A M Rabasco, M L González-Rodríguez
The purpose of this study was to compare the in vivo efficacy of several timolol (TM)-loaded liposomal formulations with current TM antiglaucoma treatment (aqueous 0.5% w/v eye drops). In this study, conventional liposomes (CL) and deformable liposomes, without (DL1) and with ethanol (DL2) were prepared and characterized. In addition, in vitro release and permeation studies, as well as in vivo lowering intraocular pressure (IOP) and biocompatibility studies were performed. It was found that the quali and quantitative lipid bilayer composition played a significant role in modifying the physical properties of vesicles...
September 15, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28923290/use-of-adult-sensory-panel-to-study-individual-differences-in-the-palatability-of-a-pediatric-hiv-treatment-drug
#19
Julie A Mennella, Phoebe S Mathew, Elizabeth D Lowenthal
PURPOSE: The recommended first-line treatment for young children infected with HIV includes the liquid formulation of the co-formulated protease inhibitors lopinavir/ritonavir (Kaletra(®) [Abbott Laboratories, Chicago, Illinois]). Clinical reports indicate that some children readily accept the taste of Kaletra, whereas others strongly reject it, which can deter therapeutic adherence and outcomes. METHODS: As a proof-of-concept approach, a sensory panel of genotyped adults was used to document the range of individual differences in the taste and palatability (hedonics) of the liquid formulation of Kaletra and other taste stimuli, including common excipients...
September 15, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28923202/dietary-linoleic-acid-and-its-oxidized-metabolites-exacerbate-liver-injury-caused-by-ethanol-via-induction-of-hepatic-proinflammatory-response-in-mice
#20
Dennis R Warner, Huilin Liu, Matthew E Miller, Christopher E Ramsden, Bin Gao, Ariel E Feldstein, Susanne Schuster, Craig J McClain, Irina A Kirpich
Alcoholic liver disease is a major human health problem leading to significant morbidity and mortality in the United States and worldwide. Dietary fat plays an important role in alcoholic liver disease pathogenesis. Herein, we tested the hypothesis that a combination of ethanol and a diet rich in linoleic acid (LA) leads to the increased production of oxidized LA metabolites (OXLAMs), specifically 9- and 13-hydroxyoctadecadienoic acids (HODEs), which contribute to a hepatic proinflammatory response exacerbating liver injury...
October 2017: American Journal of Pathology
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