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Ethanol

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https://www.readbyqxmd.com/read/29332129/aspergillus-fumigatus-increased-par-2-expression-and-elevated-proinflammatory-cytokines-expression-through-the-pathway-of-par-2-erk1-2-in-cornea
#1
Yawen Niu, Guiqiu Zhao, Cui Li, Jing Lin, Nan Jiang, Chengye Che, Jie Zhang, Qiang Xu
Purpose: To determine the role of protease-activated receptor-2 (PAR-2) in cornea infected by Aspergillus fumigatus. Methods: PAR-2 was tested in normal and infected corneas of C57BL/6 mice. Mice corneas were infected with A. fumigatus with or without pretreatment of PAR-2 antagonist (FSLLRY-NH2). Polymorphonuclear neutrophilic leukocytes (PMNs) were stimulated with 75% ethanol-killed A. fumigatus with or without pretreatment of FSLLRY-NH2. Disease severity was documented by clinical score and photographs with a slit lamp...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29331880/preventive-effects-of-indole-3-carbinol-against-alcohol-induced-liver-injury-in-mice-via-antioxidant-anti-inflammatory-and-anti-apoptotic-mechanisms-role-of-gut-liver-adipose-tissue-axis
#2
Youngshim Choi, Mohamed A Abdelmegeed, Byoung-Joon Song
Indole-3-carbinol (I3C), found in Brassica family vegetables, exhibits antioxidant, anti-inflammatory, and anti-cancerous properties. Here, we aimed to evaluate the preventive effects of I3C against ethanol (EtOH)-induced liver injury and study the protective mechanism(s) by using the well-established chronic-plus-binge alcohol exposure model. The preventive effects of I3C were evaluated by conducting various histological, biochemical, and real-time PCR analyses in mouse liver, adipose tissue, and colon, since functional alterations of adipose tissue and intestine can also participate in promoting EtOH-induced liver damage...
December 10, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29331819/new-strategy-for-determination-of-anthocyanins-polyphenols-and-antioxidant-capacity-of-brassica-oleracea-liquid-extract-using-infrared-spectroscopies-and-multivariate-regression
#3
Isadora R N de Oliveira, Jussara V Roque, Mariza P Maia, Paulo C Stringheta, Reinaldo F Teófilo
A new method was developed to determine the antioxidant properties of red cabbage extract (Brassica oleracea) by mid (MID) and near (NIR) infrared spectroscopies and partial least squares (PLS) regression. A 70% (v/v) ethanolic extract of red cabbage was concentrated to 9° Brix and further diluted (12 to 100%) in water. The dilutions were used as external standards for the building of PLS models. For the first time, this strategy was applied for building multivariate regression models. Reference analyses and spectral data were obtained from diluted extracts...
January 4, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29331817/vapochromic-behavior-of-mof-for-selective-sensing-of-ethanol
#4
Zhenhua Wang, Qianwang Chen
A MOF material, Co3[Co(CN)6]2 nanoparticles has been prepared for the effective detection of ethanol in vapor phase. When exposed to ethanol vapor, the material was changed from pink to purple, which is easily observed by naked eyes directly. We propose that the ethanol response is due to ethanol molecules entering the pores of the solid, where they alter the coordination geometry, leading to conversion of their Co centers from octahedral to tetrahedral coordination. Significantly, the change is reversible, which make the material reusable without subjecting to dynamic vacuum or slightly warming...
December 30, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29331728/the-effect-of-bioadhesive-on-the-interfacial-compatibility-and-pervaporation-performance-of-composite-membranes-by-md-and-gcmc-simulation
#5
Baohe Wang, Yan Nie, Jing Ma
Combing molecular dynamics (MD) and Grand Canonical Monte Carlo (GCMC) simulation, the effect of bioadhesive transition layer on the interfacial compatibility of the pervaporation composite membranes, and the pervaporation performance toward penetrant molecules were investigated. In our previous experimental study, the structural stability and permeability selectivity of the composite membranes were considerably enhanced by the introduction of bioadhesive carbopol (CP). In the present study, the interfacial compatibility and the interfacial energies between the chitosan (CS) separation layer, CP transition layer and the support layer were investigated, respectively...
January 5, 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29331370/preparation-and-evaluation-of-antibacterial-potential-of-pithecellobium-dulce-root-extract-against-gram-positive-and-gram-negative-bacteria
#6
Muneer Ahmad Bhat, Rayees Ahmad Malik, Poonam Prakash, Ali Mohd Lone
In the present study hexane, benzene, ethyl acetate and ethanol extracts of Pithecellobium dulce root were prepared using soxhlet extractor. The extracts were evaluated for antibacterial activity against one Gram positive (Staphylococcus aureus) and three Gram negative (Acetobacter aceti, Acetobacter aceti, Klebsiella pneumoniae) strains. Disc diffusion method revealed promising antibacterial activity of the extracts prepared in polar solvents (ethyl acetate and ethanol) compared to non-polar solvents (hexane and benzene)...
January 10, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29331316/pharmacological-activities-of-the-organic-extracts-and-chemical-fatty-acids-composition-of-the-petroleum-ether-extract-from-haplophyllum-tuberculatum-leaves
#7
Assia Hamdi, Kaouther Majouli, Amal Abdelhamid, Hela Belghith, Imed Chraief, Abderrahman Bouraoui, Zohra Marzouk, Yvan Vander Heyden
ETHNOPHARMACOLOGICAL RELEVANCE: Haplophyllum tuberculatum is used in traditional medicine to treat many disorders including inflammation and pain. The aim of this study is to investigate the organic extracts from H. tuberculatum leaves against inflammation, gastric ulcer and pain. MATERIALS AND METHODS: Acute toxicity was studied in vivo to determine the toxic doses of the leaves organic extracts. Anti-inflammatory activity was also evaluated in vivo using carrageenan-induced paw edema in Wistar rats...
January 10, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29330077/blood-ethanol-levels-are-not-related-to-coagulation-changes-as-measured-by-thromboelastography-in-traumatic-brain-injury-patients
#8
Abigail J Rao, Amber Laurie Lin, Cole Hilliard, Rongwei Fu, Tori Lennox, Ronald R Barbosa, Susan E Rowell
No abstract text is available yet for this article.
January 9, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29329855/production-of-three-types-of-krill-oils-from-krill-meal-by-a-three-step-solvent-extraction-procedure
#9
Dan Xie, Hongyan Mu, Tianpei Tang, Xiaosan Wang, Wei Wei, Jun Jin, Xingguo Wang, Qingzhe Jin
In this study, a three-step extraction method (separately use acetone, hexane, and ethanol as extraction solvent in each step) was conducted to selectively extract three types of krill oils with different compositions. The lipid yields were 5.08% in step 1, 4.80% in step 2, and 9.11% in step 3, with a total of 18.99%. The krill oil extracted with acetone in step 1 (A-KO) contained the lowest contents of phospholipids (PL) (2.32%) and n-3 polyunsaturated fatty acids (PUFA) (16.63%), but the highest levels of minor components (505...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29329842/optimization-of-microwave-assisted-extraction-of-morus-nigra-l-fruits-maximizing-tyrosinase-inhibitory-activity-with-isolation-of-bioactive-constituents
#10
Halil Koyu, Aslihan Kazan, Serdar Demir, Mehmet Zeki Haznedaroglu, Ozlem Yesil-Celiktas
Morus nigra L. is a beneficial food due to rich phenolic components. While aiming higher yields for bioactive constituents, reduction in terms of raw material, solvent, time and energy gained more importance to provide a sustainable life for human and nature. Microwave assisted extraction (MAE) of Morus nigra fruits was optimized in order to elicit process parameters maximizing bioactive metabolites and tyrosinase inhibitory activity. Spectrophotometry and UPLC-DAD-ESI-MS/MS systems were utilized for quantitative analysis of total phenol, flavonoid and anthocyanin contents...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29329651/lignans-and-diterpenes-isolated-from-tirpitzia-ovoidea-and-their-biological-activities
#11
Xue-Yan Yang, Yi-Fan Zhang, Li-Jia Liu, Yi Wang, Ming-Ying Shang, Feng Xu, Guang-Xue Liu, Shao-Qing Cai
A new lignan, tirpitzin A (17) together with 20 known compounds (1-16, and 18-21) were isolated from the ethyl acetate soluble fraction of ethanol extract of the aerial parts of Tirpitzia ovoidea. The structure of new compound was elucidated by means of spectroscopic analysis. Of the known compounds, 7-21 were isolated from Linaceae family for the first time. The pharmacological activity of the crude extracts was tested using a mouse inflammation model induced by dimethyl benzene. The results demonstrated that the ethyl acetate soluble fraction had anti-inflammatory activity...
December 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29329610/bacopa-monnieri-extracts-prevent-hydrogen-peroxide-induced-oxidative-damage-in-a-cellular-model-of-neuroblastoma-imr32-cells
#12
Gaurav Bhatia, Vikram Dhuna, Kshitija Dhuna, Manpreet Kaur, Jatinder Singh
Neurodegenerative diseases are the consequences of imbalance between the production of oxidative stress and its nullification by cellular defense mechanisms. Hydrogen peroxide (H2O2), a precursor of deleterious reactive oxygen species, elicits oxidative stress, resulting in severe brain injuries. Bacopa monnieri is well known for its nerve relaxing and memory enhancing properties. The present study was designed to evaluate the protective effects of extracts from Bacopa monnieri against H2O2 induced oxidative stress using a cellular model, neuroblastoma IMR32 cell line...
November 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29329564/phytochemical-analysis-antioxidant-and-anti-inflammatory-potential-of-feretia-apodanthera-root-bark-extracts
#13
Oluwayinka Olufunmilayo Owolabi, Dorcas Bolanle James, Ibrahim Sani, Binda T Andongma, Opeoluwa O Fasanya, Barnabas Kure
BACKGROUND: Inflammation has been implicated in many disorders, including cancer and available therapies elicit adverse effects. Plants of the family Rubiaceae have shown potency against inflammation. The anti-inflammatory and anti-oxidant potential of Feretia apodanthera was investigated in this study to evaluate its effectiveness. METHODS: The phytochemical, antioxidant and anti-inflammatory potential of root bark (n-Hexane, diethyl ether, ethanol and aqueous) extracts of Feretia apodanthera was investigated in this study...
January 12, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29329531/chemical-genomic-guided-engineering-of-gamma-valerolactone-tolerant-yeast
#14
Scott Bottoms, Quinn Dickinson, Mick McGee, Li Hinchman, Alan Higbee, Alex Hebert, Jose Serate, Dan Xie, Yaoping Zhang, Joshua J Coon, Chad L Myers, Robert Landick, Jeff S Piotrowski
BACKGROUND: Gamma valerolactone (GVL) treatment of lignocellulosic bomass is a promising technology for degradation of biomass for biofuel production; however, GVL is toxic to fermentative microbes. Using a combination of chemical genomics with the yeast (Saccharomyces cerevisiae) deletion collection to identify sensitive and resistant mutants, and chemical proteomics to monitor protein abundance in the presence of GVL, we sought to understand the mechanism toxicity and resistance to GVL with the goal of engineering a GVL-tolerant, xylose-fermenting yeast...
January 12, 2018: Microbial Cell Factories
https://www.readbyqxmd.com/read/29329097/sources-and-transformation-pathways-for-dichlorodiphenyltrichloroethane-ddt-and-metabolites-in-soils-from-northwest-fujian-china
#15
Huanfang Huang, Yuan Zhang, Wei Chen, Wenwen Chen, Dave A Yuen, Yang Ding, Yingjie Chen, Yao Mao, Shihua Qi
Dicofol (2,2,2-trichloro-1,1-bis-(p-chlorophenyl)ethanol) found in the environment is not only a miticide originated from commercial use, but also a metabolite of dichlorodiphenyltrichloroethane (DDT), which is often overlooked. To verify the sources and transformation pathways of DDT and related metabolites in soils, we measured p,p'-(dicofol + DBP) (sum of p,p'-dicofol and 4,4'-dichlorobenzophenone), DDT and six metabolites in soils from Northwest Fujian, China. The ratios of 1,1,1-trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (o,p'-DDT)/1,1,1-trichloro-2,2-bis-(p-chlorophenyl)ethane (p,p'-DDT) and the mass balance demonstrated that p,p'-(dicofol + DBP) predominantly originated from p,p'-DDT transformation rather than from actual dicofol application...
January 9, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29329075/anticoagulant-polyurethane-substrates-modified-with-poly-2-methacryloyloxyethyl-phosphorylcholine-via-si-ratrp
#16
Cheng Chi, Baohong Sun, Ninglin Zhou, Ming Zhang, Xiaohong Chu, Ping Yuan, Jian Shen
A novel catalyst system of Reverse Atom Transfer Radical Polymerization (RATRP) to prepare Polyurethane (PU) films modified by poly(2-methacryloyloxyethyl phosphorylcholine) (pMPC) was studied in this article. In this system, PU film was pretreated by LaCl3/CA ethanol solution to obtain a hydrated surface allowing more initiators to be immobilized on it. Moreover, complexes composed of silane coupling agent 3-chloropropyltrimethoxysilane (CPTM), chlorhexidine acetate (CA) and lanthanum(III) worked as ligands of copper ions as a whole during RATRP process...
January 8, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29329035/esterification-of-trans-aconitic-acid-improves-its-anti-inflammatory-activity-in-lps-induced-acute-arthritis
#17
Diego Pinto de Oliveira, Thales do Valle Moreira, Nathália Vieira Batista, José Dias de Souza Filho, Flávio Almeida Amaral, Mauro Martins Teixeira, Rodrigo Maia de Pádua, Fernão Castro Braga
trans-Aconitic acid (TAA) is an abundant constituent in the leaves of Echinodorus grandiflorus, a medicinal plant used to treat rheumatoid arthritis in Brazil. Esterification was explored as a strategy to increase lipophilicity and biopharmaceutical properties of TAA, a highly polar tricarboxylic acid. We herein report the synthesis of TAA esters via Fischer esterification with ethanol, n-butanol and n-octanol. The reaction kinetics was investigated to produce mono-, di- and tri- derivatives. Mono- and diesters of TAA were obtained as a mixture of positional isomers, whereas the triesters were recovered as pure compounds...
January 9, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29329012/oxidative-transformation-kinetics-and-pathways-of-albendazole-from-reactions-with-manganese-dioxide
#18
Sin-Yi Liou, Wan-Ru Chen
Albendazole (ABZ) is a benzimidazole-based veterinary anthelmintic used extensively in the treatment of intestinal parasites. Due to its high hydrophobicity, ABZ tends to accumulate in soils and sediments in the environment. This study aims to investigate ABZ's possible degradation by manganese oxides. Minor effects from ionic strength and metal cations on ABZ degradation were observed. By contrast, decrease of pH greatly enhanced the reaction rate. Surface complexation between ABZ and MnO2 was indicated to be the dominant control in the reaction kinetics...
December 29, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29328165/time-resolved-study-of-optical-properties-and-microscopic-dynamics-during-the-drying-of-tio2-films-by-spectral-diffusing-wave-spectroscopy
#19
Angel A Duran-Ledezma, Damián Jacinto-Méndez, Luis F Rojas-Ochoa
We present a combined experimental, theoretical, and numerical study of photon transport and microscopic dynamics in rigid and drying turbid thin films. Our setup is based in multispeckle diffusing wave spectroscopy and is adapted for frequency sweep of the illuminating source. We apply our approach to simultaneously monitor the changes in optical properties and microscopic dynamics of turbid thin films of rutile TiO2 powder dispersed in ethanol during the full drying process. Accordingly, we introduce an extension of the photon diffusion model for spectral speckle intensity correlations to account for system microscopic dynamics...
January 10, 2018: Applied Optics
https://www.readbyqxmd.com/read/29327426/quantification-of-total-cholesterol-in-human-milk-by-gas-chromatography
#20
Maurizio Beggio, Cristina Cruz-Hernandez, Pierre-Alain Golay, Le Ye Lee, Francesca Giuffrida
Human milk provides the key nutrients necessary for infant growth and development. The objective of this study was to develop and validate a method to analyze the cholesterol content in liquid human milk samples along lactation. Direct saponification of the sample using ethanolic potassium hydroxide solution under cold conditions was applied and unsaponifiable matter was separated by centrifugation. Cholesterol was converted into its trimethylsilyl ether and the derivative analyzed by gas chromatography coupled with a flame ionization detector...
January 12, 2018: Journal of Separation Science
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