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https://www.readbyqxmd.com/read/29334202/lifestyle-related-factors-associated-with-reproductive-health-in-couples-seeking-fertility-treatments-results-of-a-pilot-study
#1
Marie-Lou Piché, Véronique Babineau, Julie Robitaille, Émilie Lachance, Stephanie-May Ruchat
Background: The objective of this pilot study was to evaluate the feasibility of conducting a larger prospective cohort study, which will aim at determining the independent contribution of male and female lifestyle-related factors to assisted reproductive technology (ART) success. The study also examined whether couples seeking fertility treatments present lifestyle-related factors that may interfere with their reproductive health. MATERIALS AND METHODS: This prospective pilot study was conducted in a fertility clinic between May 2015 and February 2016...
April 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29331218/knowing-when-to-stop-aberrant-precision-and-evidence-accumulation-in-schizophrenia
#2
Roberto Limongi, Bartosz Bohaterewicz, Magdalena Nowicka, Aleksandra Plewka, Karl J Friston
Predictive coding and active inference formulations of the dysconnection hypothesis suggest that subjects with schizophrenia (SZ) hold unduly precise prior beliefs to compensate for a failure of sensory attenuation. This implies that SZ subjects should both initiate responses prematurely during evidence-accumulation tasks and fail to inhibit their responses at long stop-signal delays. SZ and healthy control subjects were asked to report the timing of billiards-ball collisions and were occasionally required to withhold their responses...
January 10, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29331003/oral-sildenafil-use-in-neonates-with-persistent-pulmonary-hypertension-of-newborn
#3
Ali Shabbir Hussain, Rehan Ali, Shakeel Ahmed, Farah Naz, Anila Haroon
BACKGROUND: The prevalence of PPHN has been estimated at 1.9 per 1000 live births. After the discovery of iNO's, its efficacy and benefit in PPHN is well established. Even in the best of centers equipped with iNo and ECMO the mortality is around 20%. Also, iNO is expensive and difficult to administer and monitor which makes it difficult choice in our part of the world. Furthermore About 40% of patients do not respond or have rebound pulmonary hypertension after discontinuation. Owing to these reasons, other treatment modalities like phosphodiesterase inhibitors such as Sildenafil need to be evaluated...
October 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29329627/comparative-efficacy-of-curcumin-and-paromomycin-against-cryptosporidium-parvum-infection-in-a-balb-c-model
#4
Mohammad Asadpour, Fatemeh Namazi, Seyed Mostafa Razavi, Saeed Nazifi
Cryptosporidium is a ubiquitous protozoan parasite causing gastrointestinal disorder in various hosts worldwide. The disease is self-limiting in the immunocompetent but life-threatening in immunodeficient individuals. Investigations to find an effective drug for the complete elimination of the Cryptosporidium infection are ongoing and urgently needed. The current study was undertaken to examine the anti-cryptosporidial efficacy of curcumin in experimentally infected mice compared with that of paromomycin. Oocysts were isolated from a pre-weaned dairy calf and identified as Cryptosporidium parvum using a nested- polymerase chain reaction (PCR) on Small subunit ribosomal ribonucleic acid (SSU rRNA) gene and sequencing analysis...
January 30, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29325833/treatment-of-graves-disease-in-children-the-portuguese-experience
#5
Olinda Marques, Ana Antunes, Maria João Oliveira
INTRODUCTION: Graves' disease (GD) is an autoimmune thyroid disease, common in adults but rare in children. The best therapeutic approach remains controversial. OBJECTIVES: To ascertain the current treatment of pediatric GD in Portugal and to assess the clinical and biochemical factors that determine definitive/long-term remission after treatment with antithyroid drugs (ATDs). PATIENTS AND METHODS: A retrospective analysis of data about pediatric GD treatment collected from a nationwide survey conducted by the Portuguese Society of Pediatric Endocrinology and Diabetology from May to August 2013...
January 8, 2018: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29324929/our-solution-for-fusion-of-simultaneusly-acquired-whole-body-scintigrams-and-optical-images-as-usesful-tool-in-clinical-practice-in-patients-with-differentiated-thyroid-carcinomas-after-radioiodine-therapy-a-useful-tool-in-clinical-practice
#6
Milovan Matovic, Milica Jankovic, Marko Barjaktarovic, Marija Jeremic
OBJECTIVE: After radioiodine therapy of differentiated thyroid cancer (DTC) patients, whole body scintigraphy (WBS) is standard procedure before releasing the patient from the hospital. A common problem is the precise localization of regions where the iod-avide tissue is located. Sometimes is practically impossible to perform precise topographic localization of such regions. METHOD: In order to face this problem, we have developed a low-cost Vision-Fusion system for web-camera image acquisition simultaneously with routine scintigraphic whole body acquisition including the algorithm for fusion of images given from both cameras...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29322401/is-it-possible-to-cure-the-symptoms-of-the-overactive-bladder-in-women
#7
Jan Krhut, Alois Martan, Roman Zachoval, Tomas Hanus, Lukas Horcicka, Kamil Svabík, Peter Zvara
PURPOSE: To evaluate the feasibility of discontinuing treatment with mirabegron once symptoms have subsided in patients with overactive bladder (OAB). METHODS: The present study evaluated a total of 159 female OAB patients (age 62.9 ± 12.36), each of which were prescribed 50 mg/day mirabegron (Time point 1-T1). Data obtained from voiding diaries and patient-reported outcome variables were assessed during follow-up visits at months 1, 3, 6, 12, 18 (T2), and 21 (T4)...
January 10, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29320422/feasibility-of-detecting-natural-frequencies-of-hydraulic-turbines-while-in-operation-using-strain-gauges
#8
David Valentín, Alexandre Presas, Matias Bossio, Mònica Egusquiza, Eduard Egusquiza, Carme Valero
Nowadays, hydropower plays an essential role in the energy market. Due to their fast response and regulation capacity, hydraulic turbines operate at off-design conditions with a high number of starts and stops. In this situation, dynamic loads and stresses over the structure are high, registering some failures over time, especially in the runner. Therefore, it is important to know the dynamic response of the runner while in operation, i.e., the natural frequencies, damping and mode shapes, in order to avoid resonance and fatigue problems...
January 10, 2018: Sensors
https://www.readbyqxmd.com/read/29319493/cyclosporine-for-the-treatment-of-lupus-nephritis-in-patients-with-systemic-lupus-erythematosus
#9
Tzu-Han Yang, Tsai-Hung Wu, Yuh-Lih Chang, Hsien-Tzung Liao, Chia-Chen Hsu, Chang-Youh Tsai, Yueh-Ching Chou
AIMS: This study aimed to assess retrospectively the efficacy and safety of cyclosporin A (CsA) therapy in patients with lupus nephritis (LN). MATERIALS AND METHODS: From September 2005 to August 2015, eligible patients with LN undergoing CsA treatment were enrolled in the study. Medical charts as well as clinical and laboratory data were retrospectively reviewed. The data were evaluated at 0, 1, 6, 12 month(s) after the start of CsA. Serum creatinine (SCr), estimated glomerular filtration rate (eGFR), urine protein/creatinine ratio (uPCR), complement components C3, C4, and anti-double stranded DNA antibody (anti-dsDNA) titers were recorded...
January 10, 2018: Clinical Nephrology
https://www.readbyqxmd.com/read/29317939/medical-treatment-for-microscopic-colitis-a-community-hospital-s-experience
#10
Abdallah Haidar, Savreet Kaur, Nancy Jackson, Jose Mari Parungao, Michael Piper, Alan Cutler
Background: Lymphocytic colitis (LC) is a chronic disorder characterized by watery diarrhea. This study sought to evaluate if LC recurs after therapy, and the time frame in which this occurs. Secondary objectives included length and type of therapy, drug-free intervals, and reasons for drug discontinuation. Methods: A retrospective chart review between January 1, 2008 and October 30, 2015 of patients with biopsy-confirmed lymphocytic, collagenous, or microscopic colitis was conducted...
December 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/29307210/bleeding-in-cancer-patients-and-its-treatment-a-review
#11
Candice Johnstone, Shayna E Rich
Bleeding is a common problem in cancer patients, related to local tumor invasion, tumor angiogenesis, systemic effects of the cancer, or anti-cancer treatments. Existing bleeds can also be exacerbated by medications such as bevacizumab, nonsteroidal anti-inflammatory drugs (NSAIDs), and anticoagulants. Patients may develop acute catastrophic bleeding, episodic major bleeding, or low-volume oozing. Bleeding may present as bruising, petechiae, epistaxis, hemoptysis, hematemesis, hematochezia, melena, hematuria, or vaginal bleeding...
December 18, 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29306651/refractory-collapse-and-severe-burn-think-about-acute-adrenal-insufficiency
#12
Ismail Aissa, Mohammed Meziane, Abdelghafour El Koundi, Mustapha Bensghir, Samir Siah, Salim Jaafar Alaoui
INTRODUCTION: Adrenal insufficiency (AI) is a rare endocrine disorder, which can in its acute form be life-threatening in case of late diagnosis or treatment. The stress during a thermal burn can easily decompensate the AI. We report the case of an acute adrenal insufficiency (AAI) discovered following a refractory collapse occurred after a severe thermal burn. CASE PRESENTATION: A 60-year-old woman was accidentally burned to the lower limbs by hot water. Total burn surface area was 36 %...
December 29, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29301446/real-time-estimation-of-lesion-depth-and-control-of-radiofrequency-ablation-within-ex-vivo-animal-tissues-using-a-neural-network
#13
Yearnchee Curtis Wang, Terence Chee-Hung Chan, Alan Varteres Sahakian
BACKGROUND: Radiofrequency ablation (RFA), a method of inducing thermal ablation (cell death), is often used to destroy tumours or potentially cancerous tissue. Current techniques for RFA estimation (electrical impedance tomography, Nakagami ultrasound, etc.) require long compute times (≥ 2 s) and measurement devices other than the RFA device. This study aims to determine if a neural network (NN) can estimate ablation lesion depth for control of bipolar RFA using complex electrical impedance - since tissue electrical conductivity varies as a function of tissue temperature - in real time using only the RFA therapy device's electrodes...
January 4, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29300281/the-ios-have-it-a-prospective-observational-study-of-vascular-access-success-rates-in-patients-in-extremis-using-video-review
#14
Kristen M Chreiman, Ryan P Dumas, Mark J Seamon, Patrick K Kim, Patrick M Reilly, Lewis J Kaplan, Jason D Christie, Daniel N Holena
BACKGROUND: Quick and successful vascular access in injured patients arriving in extremis is crucial to enable early resuscitation and rapid OR transport for definitive repair. We hypothesized that intraosseous (IO) access would be faster and have higher success rates than peripheral IVs (PIVs) or central venous catheters (CVCs). METHODS: High-definition video recordings of resuscitations for all patients undergoing Emergency Department Thoracotomy (EDT) from 4/2016-7/2017 were reviewed as part of a quality improvement initiative...
January 4, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29287834/slc19a3-related-disorder-treatment-implication-and-clinical-outcome-of-2-new-patients
#15
Davide Tonduti, Federica Invernizzi, Celeste Panteghini, Lorenzo Pinelli, Silvia Battaglia, Elisa Fazzi, Giovanna Zorzi, Isabella Moroni, Barbara Garavaglia, Luisa Chiapparini, Nardo Nardocci
Encephalopathies with neostriatal involvement constitute a heterogeneous group of acquired and genetically inherited conditions that include Bilateral Striatal Necrosis (BSN) and other Striatal Lesions (SL) (Tonduti et al). We describe two new patients suffering from BSN due to biallelic SLC19A3 mutations. In the first patient vitamin supplementation was started early on, resulting in the remission of the clinical picture, and an almost complete normalization of the neuroradiological findings. In the second one treatment was started late, compliance was irregular and the resulting clinical outcome was poor...
December 16, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29283140/aripiprazole-induced-transient-myopia-a-rare-entity
#16
K V Praveen Kumar, P Chiranjeevi, Md Shahid Alam
Aripiprazole is a new drug for the treatment of adults with schizophrenia. Ocular side effects of aripiprazole are very rare. Review of literature revealed few cases of aripiprazole-induced myopia. We report a rare case of aripiprazole-induced transient myopia. A 22-year-old female patient presented to the department of psychiatry with worsening of symptoms of schizophrenia and was started on aripiprazole. She presented with complaints of blurring of vision in both eyes for 1 week which started on the 3rd day following the use of aripiprazole...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29282142/promoting-recruitment-using-information-management-efficiently-prime-a-stepped-wedge-cluster-randomised-trial-of-a-complex-recruitment-intervention-embedded-within-the-restart-or-stop-antithrombotics-randomised-trial
#17
Amy E Maxwell, Richard A Parker, Jonathan Drever, Anthony Rudd, Martin S Dennis, Christopher J Weir, Rustam Al-Shahi Salman
BACKGROUND: Few interventions are proven to increase recruitment in clinical trials. Recruitment to RESTART, a randomised controlled trial of secondary prevention after stroke due to intracerebral haemorrhage, has been slower than expected. Therefore, we sought to investigate an intervention to boost recruitment to RESTART. METHODS/DESIGN: We conducted a stepped-wedge, cluster randomised trial of a complex intervention to increase recruitment, embedded within the RESTART trial...
December 28, 2017: Trials
https://www.readbyqxmd.com/read/29276071/enhancement-of-force-patterns-classification-based-on-gaussian-distributions
#18
Thomas Ertelt, Ilja Solomonovs, Thomas Gronwald
Description of the patterns of ground reaction force is a standard method in areas such as medicine, biomechanics and robotics. The fundamental parameter is the time course of the force, which is classified visually in particular in the field of clinical diagnostics. Here, the knowledge and experience of the diagnostician is relevant for its assessment. For an objective and valid discrimination of the ground reaction force pattern, a generic method, especially in the medical field, is absolutely necessary to describe the qualities of the time-course...
December 13, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29274889/new-onset-autoimmune-hepatitis-during-anti-tumor-necrosis-factor-alpha-treatment-in-children
#19
Amanda Ricciuto, Binita M Kamath, Thomas D Walters, Karen Frost, Nicholas Carman, Peter C Church, Simon C Ling, Anne M Griffiths
OBJECTIVES: To evaluate a large anti-tumor necrosis factor (TNF)-treated pediatric inflammatory bowel disease cohort for drug-induced liver injury (DILI) following presentation of an index case with suspected DILI with autoimmune features after infliximab exposure. To characterize the incidence, natural history, and risk factors for liver enzyme elevation with anti-TNF use. STUDY DESIGN: We reviewed the index case and performed a retrospective cohort study of 659 children receiving anti-TNF therapy between 2000 and 2015 at a tertiary pediatric inflammatory bowel disease center...
December 21, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29261005/efficacy-and-safety-of-apatinib-monotherapy-in-advanced-bone-and-soft-tissue-sarcoma-an-observational-study
#20
Baorang Zhu, Jing Li, Qiaosheng Xie, Liyan Diao, Lvhua Gai, Wuwei Yang
Sarcomas are rare but malignant tumors with high risks of local recurrence and distant metastasis. Anti-angiogenic therapy is a potential strategy against un-controlled and not-organized tumor angiogenesis. We aimed to assess the safety and efficacy of apatinib, an oral tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor-2, in patients with advanced sarcoma. Thirty-one patients who received initial apatinib between September 2015 and August 2016 were retrospectively reviewed. Among them, 19 (61...
December 20, 2017: Cancer Biology & Therapy
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