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https://www.readbyqxmd.com/read/29578483/polypharmacy-and-potentially-inappropriate-medication-in-people-with-dementia-a-nationwide-study
#1
Rachel Underlien Kristensen, Ane Nørgaard, Christina Jensen-Dahm, Christiane Gasse, Theresa Wimberley, Gunhild Waldemar
BACKGROUND: Polypharmacy (use of ≥5 different medications) and potentially inappropriate medication (PIM) are well-known risk factors for numerous negative health outcomes. However, the use of polypharmacy and PIM in people with dementia is not well-described. OBJECTIVE: To examine the prevalence of polypharmacy and PIM in older people with and without dementia in a nationwide population. METHODS: Cross-sectional study of the Danish population aged ≥65 in 2014 (n = 1,032,120) based on register data, including information on diagnoses and dispensed prescriptions...
March 23, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29421666/compatibility-of-medication-with-priscus-criteria-and-identification-of-drug-interactions-in-a-large-cohort-of-patients-with-copd
#2
Jana Graf, Tanja Lucke, Ronald Herrera, Henrik Watz, Rolf Holle, Claus Vogelmeier, Joachim H Ficker, Rudolf A Jörres
Patients with COPD are often of advanced age and have a high number of medications due to their lung disease and comorbidities. Thus they are at risk for unwanted effects from drugs, either due to age or due to interactions between drugs. These issues are not clarified. We therefore assessed the number of medications and potential adverse effects in a large cohort of patients with COPD. The analysis was performed in 2741 patients of the German COPD cohort COSYCONET, using baseline data (visit 1) and follow-up data after about 1...
February 5, 2018: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29258401/preventable-adrs-leading-to-hospitalization-results-of-a-long-term-prospective-safety-study-with-6-427-adr-cases-focusing-on-elderly-patients
#3
MULTICENTER STUDY
S Schmiedl, M Rottenkolber, J Szymanski, B Drewelow, W Siegmund, M Hippius, K Farker, I R Guenther, J Hasford, P A Thuermann
BACKGROUND: Studies evaluating the impact of age and potentially inappropriate medication (PIM) on avoidable adverse drug reactions (ADRs) are scarce. METHODS: In this prospective, multi-center, long-term (8.5 years) observational study, we analysed ADRs leading to hospitalization in departments of internal medicine. ADRs causality and preventability were assessed using standardised algorithms. PIM was defined based on the PRISCUS-list. Multivariate analyses and estimation of ADR incidence rates were conducted...
February 2018: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29202811/high-prevalence-of-prescription-of-psychotropic-drugs-for-older-patients-in-a-general-hospital
#4
Inken Arnold, Kati Straube, Wolfgang Himmel, Stephanie Heinemann, Vivien Weiss, Laura Heyden, Eva Hummers-Pradier, Roland Nau
BACKGROUND: Many elderly patients receive psychotropic drugs. Treatment with psychotropic agents is associated with serious side effects including an increased risk of falls and fractures. Several psychotropic drugs are considered potentially inappropriate for treatment of the elderly. METHODS: A retrospective chart review was conducted covering all patients aged ≥ 65 years who were admitted to Evangelisches Krankenhaus Göttingen-Weende between 01/01/2013 and 03/31/2013...
December 4, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29192242/impact-related-microspherules-in-late-pleistocene-alaskan-and-yukon-muck-deposits-signify-recurrent-episodes-of-catastrophic-emplacement
#5
Jonathan T Hagstrum, Richard B Firestone, Allen West, James C Weaver, Ted E Bunch
Large quantities of impact-related microspherules have been found in fine-grained sediments retained within seven out of nine, radiocarbon-dated, Late Pleistocene mammoth (Mammuthus primigenius) and bison (Bison priscus) skull fragments. The well-preserved fossils were recovered from frozen "muck" deposits (organic-rich silt) exposed within the Fairbanks and Klondike mining districts of Alaska, USA, and the Yukon Territory, Canada. In addition, elevated platinum abundances were found in sediment analysed from three out of four fossil skulls...
November 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29138901/-which-factors-are-associated-with-the-use-of-potentially-inadequate-medications-pim-in-the-elderly-results-from-the-german-health-interview-and-examination-survey-degs1
#6
Heinz G Endres, Petra Kaufmann-Kolle, Hildtraud Knopf, Petra A Thürmann
BACKGROUND: Recent studies demonstrate a relationship between the prescription of potentially inappropriate medications (PIM) for patients 65 years or older and an increased risk for adverse events, in particular hospitalisations. The RKI conducted DEGS1-Survey ("German health interview and examination survey for adults") provides a representative sample of the target population to identify determinants for PIM use. OBJECTIVE: The aim of this study was to determine characteristics of older persons in Germany, who currently use PIM, and if there are subpopulations among older persons with a particularly high PIM use...
January 2018: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28990160/monitoring-of-potentially-inappropriate-prescriptions-in-older-inpatients-a-french-multicenter-study
#7
MULTICENTER STUDY
Irène Pandraud-Riguet, Dominique Bonnet-Zamponi, Elsa Bourcier, Marion Buyse, Sandra Laribe-Caget, Patrick Frémont, Eric Pautas, Christiane Verny, Patrick Hindlet, Christine Fernandez
OBJECTIVES: To determine whether potentially inappropriate medications (PIMs) or potentially inappropriate associations (PIAs) prescribed knowingly are associated with patient monitoring. DESIGN: Prospective observational study. SETTING: Geriatric units (n = 56) in 28 hospitals. PARTICIPANTS: Inpatients aged 75 and older (N = 1,327). MEASUREMENTS: Potentially inappropriate prescriptions (PIP) were defined as a PIM or a PIA selected by an expert board from lists of explicit criteria (Beers, Priscus, Laroche, French Health Agency) using a Delphi process...
December 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28942203/potentially-inappropriate-medication-association-between-the-use-of-antidepressant-drugs-and-the-subsequent-risk-for-dementia
#8
Kathrin Heser, Tobias Luck, Susanne Röhr, Birgitt Wiese, Hanna Kaduszkiewicz, Anke Oey, Horst Bickel, Edelgard Mösch, Siegfried Weyerer, Jochen Werle, Christian Brettschneider, Hans-Helmut König, Angela Fuchs, Michael Pentzek, Hendrik van den Bussche, Martin Scherer, Wolfgang Maier, Steffi G Riedel-Heller, Michael Wagner
BACKGROUND: Potentially inappropriate medication (PIM) is associated with an increased risk for detrimental health outcomes in elderly patients. Some antidepressant drugs are considered as PIM, but previous research on the association between antidepressants and subsequent dementia has been inconclusive. Therefore, we investigated whether the intake of antidepressants, particularly of those considered as PIM according to the Priscus list, would predict incident dementia. METHODS: We used data of a prospective cohort study of non-demented primary care patients (n = 3239, mean age = 79...
September 14, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28939983/-drug-therapy-for-older-people-choosing-wisely
#9
REVIEW
Martin Wehling
Elderly people are the most rapidly growing sector of our society. Due to their multimorbidity they are exposed to a multitude of medications, which are accompanied by chances and risks. The problem of inappropriate medication in the elderly is exacerbated by the fact that only a holistic view can help these patients and that this is predominantly the responsibility of the general practitioner. The closely measured paid contact time is often insufficient to optimize complex medications. Clinically successfully tested aids in the form of lists give reason for hope: in particular, the positive/negative assessment of limitations of the elderly with respect to drugs by the STOPP/START criteria and the FORTA classification are clinically successful aids...
December 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28871317/-drug-therapy-safety-at-the-transition-from-hospital-to-community-medicine
#10
M Hahn, S C Roll, J Klein
OBJECTIVE: We evaluated the qualitative and quantitative changes of medications during the stay on a geriatric-psychiatric ward where the medication was optimized by a clinical pharmacist, and after discharge. The goal of the study was to analyze the continuity of the medication at the transfer from hospital to ambulatory care. METHODS: We interviewed 41 patients on the phone about their drug regimen 4 and 12 weeks after discharge. Medications were compared to their discharge medication...
September 4, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/28289222/fossil-and-genomic-evidence-constrains-the-timing-of-bison-arrival-in-north-america
#11
Duane Froese, Mathias Stiller, Peter D Heintzman, Alberto V Reyes, Grant D Zazula, André E R Soares, Matthias Meyer, Elizabeth Hall, Britta J L Jensen, Lee J Arnold, Ross D E MacPhee, Beth Shapiro
The arrival of bison in North America marks one of the most successful large-mammal dispersals from Asia within the last million years, yet the timing and nature of this event remain poorly determined. Here, we used a combined paleontological and paleogenomic approach to provide a robust timeline for the entry and subsequent evolution of bison within North America. We characterized two fossil-rich localities in Canada's Yukon and identified the oldest well-constrained bison fossil in North America, a 130,000-y-old steppe bison, Bison cf...
March 28, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28271916/prevalence-of-inappropriate-medication-use-in-residential-long-term-care-facilities-for-the-elderly-a-systematic-review
#12
REVIEW
Hannelore Storms, Kristel Marquet, Bert Aertgeerts, Neree Claes
BACKGROUND: Multi-morbidity and polypharmacy of the elderly population enhances the probability of elderly in residential long-term care facilities experiencing inappropriate medication use. OBJECTIVES: The aim is to systematically review literature to assess the prevalence of inappropriate medication use in residential long-term care facilities for the elderly. METHODS: Databases (MEDLINE, EMBASE) were searched for literature from 2004 to 2016 to identify studies examining inappropriate medication use in residential long-term care facilities for the elderly...
December 2017: European Journal of General Practice
https://www.readbyqxmd.com/read/28224283/health-service-use-costs-and-adverse-events-associated-with-potentially-inappropriate-medication-in-old-age-in-germany-retrospective-matched-cohort-study
#13
Dirk Heider, Herbert Matschinger, Andreas D Meid, Renate Quinzler, Jürgen-Bernhard Adler, Christian Günster, Walter E Haefeli, Hans-Helmut König
BACKGROUND: Drug-related problems are an important healthcare safety concern in the growing population of older people. Prescription of potentially inappropriate medication (PIM) is one aspect of this concern that is considered to increase the risk of adverse health outcomes. OBJECTIVE: The aim of the Health Economics of Potentially Inappropriate Medication (HEPIME) study was to analyze the association between the prescription of PIMs according to the German PRISCUS list and healthcare utilization, healthcare costs, and the occurrence of adverse events in old age...
April 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28212616/general-practitioners-views-on-long-term-prescription-and-use-of-problematic-and-potentially-inappropriate-medication-for-oldest-old-patients-a-qualitative-interview-study-with-gps-cim-triad-study
#14
Nadine Janis Pohontsch, Kathrin Heser, Antje Löffler, Britta Haenisch, Debora Parker, Tobias Luck, Steffi G Riedel-Heller, Wolfgang Maier, Frank Jessen, Martin Scherer
BACKGROUND: Potentially inappropriate medication (PIM) is defined as medication with uncertain therapeutic effects and/or potential adverse drug reactions outweighing the clinical benefits. The prescription rate of PIM for oldest-old patients is high despite the existence of lists of PIM (e.g. the PRISCUS list) and efforts to raise awareness. This study aims at identifying general practitioners' views on PIM and aspects affecting the (long-term) use of PIM. METHODS: As part of the CIM-TRIAD study, we conducted semi-structured, qualitative interviews with 47 general practitioners, discussing 25 patients with and 22 without PIM (according to the PRISCUS list)...
February 17, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28187706/genome-data-on-the-extinct-bison-schoetensacki-establish-it-as-a-sister-species-of-the-extant-european-bison-bison-bonasus
#15
Pauline Palacio, Véronique Berthonaud, Claude Guérin, Josie Lambourdière, Frédéric Maksud, Michel Philippe, Delphine Plaire, Thomas Stafford, Marie-Claude Marsolier-Kergoat, Jean-Marc Elalouf
BACKGROUND: The European bison (Bison bonasus), now found in Europe and the Caucasus, has been proposed to originate either from the extinct steppe/extant American bison lineage or from the extinct Bison schoetensacki lineage. Bison schoetensacki remains are documented in Eurasian Middle Pleistocene sites, but their presence in Upper Pleistocene sites has been questioned. Despite extensive genetic studies carried out on the steppe and European bison, no remains from the fossil record morphologically identified as Bison schoetensacki has been analyzed up to now...
February 10, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/27769298/past-climate-changes-population-dynamics-and-the-origin-of-bison-in-europe
#16
Diyendo Massilani, Silvia Guimaraes, Jean-Philip Brugal, E Andrew Bennett, Malgorzata Tokarska, Rose-Marie Arbogast, Gennady Baryshnikov, Gennady Boeskorov, Jean-Christophe Castel, Sergey Davydov, Stéphane Madelaine, Olivier Putelat, Natalia N Spasskaya, Hans-Peter Uerpmann, Thierry Grange, Eva-Maria Geigl
BACKGROUND: Climatic and environmental fluctuations as well as anthropogenic pressure have led to the extinction of much of Europe's megafauna. The European bison or wisent (Bison bonasus), one of the last wild European large mammals, narrowly escaped extinction at the onset of the 20th century owing to hunting and habitat fragmentation. Little is known, however, about its origin, evolutionary history and population dynamics during the Pleistocene. RESULTS: Through ancient DNA analysis we show that the emblematic European bison has experienced several waves of population expansion, contraction, and extinction during the last 50,000 years in Europe, culminating in a major reduction of genetic diversity during the Holocene...
October 21, 2016: BMC Biology
https://www.readbyqxmd.com/read/27754477/early-cave-art-and-ancient-dna-record-the-origin-of-european-bison
#17
Julien Soubrier, Graham Gower, Kefei Chen, Stephen M Richards, Bastien Llamas, Kieren J Mitchell, Simon Y W Ho, Pavel Kosintsev, Michael S Y Lee, Gennady Baryshnikov, Ruth Bollongino, Pere Bover, Joachim Burger, David Chivall, Evelyne Crégut-Bonnoure, Jared E Decker, Vladimir B Doronichev, Katerina Douka, Damien A Fordham, Federica Fontana, Carole Fritz, Jan Glimmerveen, Liubov V Golovanova, Colin Groves, Antonio Guerreschi, Wolfgang Haak, Tom Higham, Emilia Hofman-Kamińska, Alexander Immel, Marie-Anne Julien, Johannes Krause, Oleksandra Krotova, Frauke Langbein, Greger Larson, Adam Rohrlach, Amelie Scheu, Robert D Schnabel, Jeremy F Taylor, Małgorzata Tokarska, Gilles Tosello, Johannes van der Plicht, Ayla van Loenen, Jean-Denis Vigne, Oliver Wooley, Ludovic Orlando, Rafał Kowalczyk, Beth Shapiro, Alan Cooper
The two living species of bison (European and American) are among the few terrestrial megafauna to have survived the late Pleistocene extinctions. Despite the extensive bovid fossil record in Eurasia, the evolutionary history of the European bison (or wisent, Bison bonasus) before the Holocene (<11.7 thousand years ago (kya)) remains a mystery. We use complete ancient mitochondrial genomes and genome-wide nuclear DNA surveys to reveal that the wisent is the product of hybridization between the extinct steppe bison (Bison priscus) and ancestors of modern cattle (aurochs, Bos primigenius) before 120 kya, and contains up to 10% aurochs genomic ancestry...
October 18, 2016: Nature Communications
https://www.readbyqxmd.com/read/27747830/potentially-inappropriate-medication-use-in-multimorbid-elderly-inpatients-differences-between-the-forta-priscus-and-stopp-ratings
#18
Beate Wickop, Steffen Härterich, Christian Sommer, Anne Daubmann, Michael Baehr, Claudia Langebrake
BACKGROUND: Several classifications to identify and avoid use of potentially inappropriate medications (PIMs) in the elderly have been published. To what extent these classifications match each other and whether there are differences in the prevalence of PIM use at admission, during the inpatient stay and at discharge are largely unreported. OBJECTIVES: To determine the PIM prevalence in elderly patients at a university hospital, with a special focus on different classification systems and the chronological sequence, and to examine a possible association between PIM use and the reason for admission, as well as severe side effects and consequences of PIM use during hospitalization...
September 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27743469/polypharmacy-an-upward-trend-with-unpredictable-effects
#19
REVIEW
Dirk Moßhammer, Hannah Haumann, Klaus Mörike, Stefanie Joos
BACKGROUND: Guideline-oriented treatments can lead to polypharmacy, i.e., the simultaneous long-term use of multiple drugs. Polypharmacy mainly affects elderly patients. The goal of this review is to survey the current scientific evidence about polypharmacy, focusing on clinical endpoints, and to point out implications for medical practice and research. METHODS: This selective literature review is based on pertinent publications that were retrieved by a selective search in PubMed employing the terms "polypharmacy AND general practice...
September 23, 2016: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/27716668/potentially-inappropriate-medication-in-community-dwelling-primary-care-patients-who-were-screened-positive-for-dementia
#20
Diana Wucherer, Tilly Eichler, Johannes Hertel, Ingo Kilimann, Steffen Richter, Bernhard Michalowsky, Jochen René Thyrian, Stefan Teipel, Wolfgang Hoffmann
BACKGROUND: Potentially inappropriate medication (PIM) in older people is a risk factor for adverse drug effects. This risk is even higher in older people with dementia (PWD). OBJECTIVE: Our study aimed to determine (1) the prevalence of PIM among primary care patients who were screened positive for dementia and (2) the sociodemographic and clinical variables associated with the use of PIM. METHODS: DelpHi-MV (Dementia: life- and person-centered help in Mecklenburg-Western Pomerania) is a general practitioner-based, cluster-randomized, controlled intervention study to implement and evaluate an innovative concept of collaborative dementia care management in Germany...
2017: Journal of Alzheimer's Disease: JAD
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