keyword
https://read.qxmd.com/read/38201524/the-diagnostic-yield-and-implications-of-targeted-founder-pathogenic-variant-testing-in-an-israeli-cohort
#21
JOURNAL ARTICLE
Aasem Abu Shtaya, Inbal Kedar, Samar Mattar, Ahmad Mahamid, Lina Basel-Salmon, Sarit Farage Barhom, Sofia Naftaly Nathan, Nurit Magal, Noy Azulay, Michal Levy Zalcberg, Rakefet Chen-Shtoyerman, Ori Segol, Mor Seri, Gili Reznick Levi, Shiri Shkedi-Rafid, Chana Vinkler, Iris Netzer, Ofir Hagari Bechar, Liat Chamma, Sari Liberman, Yael Goldberg
Founder pathogenic variants (PVs) are prevalent in Israel. This study investigated the current practice of offering cancer patients two-step genetic testing, starting with targeted testing for recurring founder PVs, followed, if negative, by next-generation sequencing. A total of 2128 subjects with cancer or a positive family history underwent oncogenetic testing with a panel of 51 recurring PVs at a tertiary medical center in March 2020-January 2023. Those with a known familial PV (n = 370) were excluded from the analysis...
December 24, 2023: Cancers
https://read.qxmd.com/read/38180788/colorectal-cancer-screening-at-age-45-years-in-israel-cost-effectiveness-and-global-implications
#22
JOURNAL ARTICLE
Elizabeth E Half, Zohar Levi, Ajitha Mannalithara, Moshe Leshno, Irit Ben-Aharon, Naim Abu-Freha, Barbara Silverman, Uri Ladabaum
BACKGROUND: Colorectal cancer (CRC) incidence at ages <50 years is increasing worldwide. Screening initiation was lowered to 45 years in the United States. The cost-effectiveness of initiating CRC screening at 45 years in Israel was assessed with the aim of informing national policy and addressing internationally relevant questions. METHODS: A validated CRC screening model was calibrated to Israeli data and examined annual fecal immunochemical testing (FIT) or colonoscopy every 10 years from 45 to 74 years (FIT45-74 or Colo45-74) versus from 50 to 74 years (FIT50-74 or Colo50-74)...
January 5, 2024: Cancer
https://read.qxmd.com/read/38175148/genetics-of-parkinson-s-disease-state-of-the-art-and-role-in-clinical-settings
#23
JOURNAL ARTICLE
Jarosław Dulski, Owen A Ross, Zbigniew K Wszolek
INTRODUCTION: Advances in sequencing technologies have enabled extensive genetic testing on an individual basis. Genome-wide association studies (GWAS) have provided insight into the pathophysiology of PD. Additionally, direct-to-consumer genetic testing has enabled the identification of genetic diseases and risk factors without genetic counselling. As genetics increasingly permeates clinical practice, this paper aims to summarise the most important information on genetics in PD forclinical practitioners...
January 4, 2024: Neurologia i Neurochirurgia Polska
https://read.qxmd.com/read/38167112/weight-stigma-in-healthcare-settings-the-experience-of-arab-and-jewish-bariatric-surgery-candidates-in-israel
#24
JOURNAL ARTICLE
Yara Zahra-Zeitoun, Roni Elran-Barak, Rawan Salameh-Dakwar, Dvir Froylich, Gideon Sroka, Ahmed Assalia, Yael Latzer
BACKGROUND: Weight-related stigma and discrimination are prevalent in our society with adverse biopsychosocial outcomes to people with obesity and morbid obesity. Studies suggest that weight bias in healthcare settings are quite prevalent, but there have been, as far as we know, lack of studies examining prevalence and correlates of weight bias experiences among bariatric surgery candidates in Israel. We aim to understand the nature and prevalence of weight stigma among bariatric surgery candidates...
January 2, 2024: Israel Journal of Health Policy Research
https://read.qxmd.com/read/38165779/unraveling-the-genome-familial-mediterranean-fever
#25
JOURNAL ARTICLE
Alexandra W Koehler
Familial Mediterranean fever (FMF) is an inherited, autoinflammatory disease with a high prevalence in Middle Eastern and Mediterranean populations including Turks, Iranian, Spanish, Sephardic Jews, Arabs, and other Mediterranean ethnic groups. Autoinflammatory diseases are genetically predetermined disorders with multisystem effects primarily caused by defects in innate immunity. Although primarily known for an autosomal recessive mode of inheritance, there are increasing case reports associated with single Mediterranean fever (MEFV) mutation or dominant transmission...
January 1, 2024: Journal of the American Association of Nurse Practitioners
https://read.qxmd.com/read/38155281/cultural-aspects-of-health-care-for-ethiopian-jewish-immigrants-in-israel-a-literature-review
#26
JOURNAL ARTICLE
Yulia Treister-Goltzman, Roni Peleg
The unique health-related traditions, perceptions, and communication patterns of Ethiopian immigrants are challenging to Israeli healthcare providers who are trained in western medicine. The aim of this review was to conduct a survey of traditions, beliefs, and symptom reporting by Ethiopian immigrants and culturally oriented interventions to improve the care of Ethiopian immigrants. We used the keywords "Ethiopian immigrants Israel" and "Ethiopian Jews." Of 418 articles initially retrieved, 35 satisfied the inclusion and exclusion criteria...
December 28, 2023: Journal of Religion and Health
https://read.qxmd.com/read/38147241/investigation-of-pesticide-residues-level-on-commonly-consumed-leafy-vegetables-picked-from-the-central-market-in-jeddah-saudi-arabia
#27
JOURNAL ARTICLE
Rawan S Almutiriy, Afnan M Alnajeebi, Manal E A Elhalwagy, Omer A Thabet, Fahad K Alenzi, Mona M Aljadani
This study aimed to investigate the presence of pesticide residues in a variety of commonly consumed leafy vegetables, including Grape leaves, Lettuce, Arugula, Spinach, Purslane, Ocimum, Parsley, Jew's mallow, Celery, Coriander, and Mint. A total of 100 samples were collected from the Central Market of Jeddah, Kingdom of Saudi Arabia. Our methodology involved employing the Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) extraction method in combination with Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) to analyze a comprehensive database of 237 distinct pesticides...
December 26, 2023: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38130397/-gcm2-p-tyr394ser-variant-in-ashkenazi-israeli-patients-with-suspected-familial-isolated-hyperparathyroidism
#28
JOURNAL ARTICLE
Auryan Szalat, Shoshana Shpitzen, Rena Pollack, Haggi Mazeh, Ronen Durst, Vardiella Meiner
CONTEXT: A germline mutation can be identified in up to 10% of patients with primary hyperparathyroidism (PHPT). In 2017, a high frequency of the GCM2 [(NM_ 004752.4) c.1181A> C; p.Tyr394Ser; rs142287570] variant was reported in PHPT Ashkenazi Jews (AJ). OBJECTIVE: To evaluate the presence of the GCM2 p.Tyr394Ser variant in Israeli patients addressed for genetic evaluation to characterize their phenotype and clinical management. METHOD: Patients with PHPT who underwent addressed for genetic screening for suspected familial hypocalciuric hypercalcemia (FHH), a family history of isolated hyperparathyroidism (FIHP), or failed parathyroidectomy with persistent PHPT were recruited...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/38090167/the-psychology-of-romantic-relationships-motivations-and-mate-preferences
#29
JOURNAL ARTICLE
Eugene Tartakovsky
INTRODUCTION: This study investigates motivations to engage in romantic relationships. We examine the structure of romantic motivations and their connections with personal values and mate preferences. METHOD: The study was conducted in Israel among young men and women looking for a romantic partner ( n  = 1,121, 40% male, age 18-30). RESULTS: Data analysis demonstrated that basic romantic motivations form a circumplex that may be partitioned into four higher-order romantic motivations: love and care, family and children, status and resources, and sex and adventure...
2023: Frontiers in Psychology
https://read.qxmd.com/read/38085273/-we-used-to-have-four-seasons-but-now-there-is-only-one-perceptions-concerning-the-changing-climate-and-environment-in-a-diverse-sample-of-israeli-older-persons
#30
JOURNAL ARTICLE
Liat Ayalon, Natalie Ulitsa, Hanan AboJabel, Shelly Engdau-Vanda
Solastalgia is the pain caused by the loss of solace and isolation from one's environment. Solastalgia is contrasted with nostalgia, which is defined as melancholy characterized by homesickness or the distance from one's home. The present study examines the two concepts of solastalgia and nostalgia in the context of climate change among diverse populations of older Israelis. In total, 50 older persons from four different population groups (e.g., veteran Israeli Jews, Israeli Arabs, immigrants from the former Soviet Union, and Ethiopian immigrants) were interviewed...
December 12, 2023: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://read.qxmd.com/read/38052840/correlation-between-coronavirus-conspiracism-and-antisemitism-a-cross-sectional-study-in-the-united-kingdom
#31
JOURNAL ARTICLE
Daniel Allington, David Hirsh, Louise Katz
This article presents the findings of a survey of UK-resident adults ([Formula: see text] = 1790) carried out in December 2021 and designed to test for a relationship between antisemitism and coronavirus conspiracism. Antisemitism was measured using the Generalised Antisemitism (GeAs) scale, and coronavirus conspiracism was measured using a version of the Flexible Inventory of Conspiracy Suspicions (FICS). Hypotheses and methodology were pre-registered, and all data and code are open. There was found to be a positive correlation between coronavirus conspiracy suspicions and Generalised Antisemitism, robust to demographic controls...
December 5, 2023: Scientific Reports
https://read.qxmd.com/read/38024120/examining-ethnic-disparities-in-digital-healthcare-services-utilization-insights-from-israel
#32
JOURNAL ARTICLE
Samira Obeid, Michal Mashiach-Eizenberg, Amit Gur, Ilana Lavy
PURPOSE: The purpose of this study was to examine ethnic disparities in the utilization of digital healthcare services (DHS) in Israel and explore the characteristics and factors influencing DHS use among the Arab minority and Jewish majority populations. METHODS: A cross-sectional correlational design was employed to collect data from 606 Israeli participants, 445 Jews, and 161 Arabs. Participants completed a digital questionnaire that assessed DHS utilization, digital health literacy, attitudes towards DHS, and demographic variables...
2023: Journal of Multidisciplinary Healthcare
https://read.qxmd.com/read/38012429/-he-should-party-a-little-less-evolving-orthodox-religiosities-in-psychotherapeutic-interventions-among-jewish-gay-men
#33
JOURNAL ARTICLE
Einat Bar Dror, Yehuda C Goodman
Drawing on interviews with Jewish Orthodox psychotherapists in Israel and on sources that represent the social, political, and cultural milieu within which these therapists work, we analyze the practices they use when working with religious gay men. Given debates and prohibitions on homosexuality in Jewish law, the therapists deploy three practices: reproducing religious norms, allowing homosexuality to be privately acknowledged while advocating its concealment from the public eye, or adopting religious distinctions that enable two men to live together while abstaining from sexual intercourse...
November 27, 2023: Culture, Medicine and Psychiatry
https://read.qxmd.com/read/37980617/disparity-in-helicobacter-pylori-positivity-among-israeli-adults-with-uninvestigated-dyspepsia-in-an-urban-setting-with-mixed-ethnicity
#34
JOURNAL ARTICLE
Ibrahim Zvidi, Ram Dickman, Doron Boltin
BACKGROUND: Helicobacter pylori (H. pylori) prevalence varies according to both geographical region and ethnicity. The interplay between these two factors has been poorly studied. OBJECTIVES: To determine the positivity rate of H. pylori infection among Jewish and Arab patients who live in a mixed urban center in Israel. METHODS: Between November 2009 and September 2014, dyspeptic patients referred to a gastroenterology clinic in Lod, Israel, were enrolled in a prospective study...
November 2023: Israel Medical Association Journal: IMAJ
https://read.qxmd.com/read/37978134/strategies-for-the-management-of-patients-with-pancreatic-cancer-with-parp-inhibitors
#35
JOURNAL ARTICLE
Talia Golan, Maria Raitses-Gurevich, Tamar Beller, James Carroll, Jonathan R Brody
A subset of patients with pancreatic adenocarcinomas (PDAC) harbor mutations that are exploitable in the context of DNA-damage response and repair (DDR) inhibitory strategies. Between 8-18% of PDACs harbor specific mutations in the DDR pathway such as BRCA1/2 mutations, and a higher prevalence exists in high-risk populations (e.g., Ashkenazi Jews). Herein, we will review the current trials and data on the treatment of PDAC patients who harbor such mutations and who appear sensitive to platinum and/or poly ADP ribose polymerase inhibitor (PARPi) based therapies due to a concept known as synthetic lethality...
2023: Cancer Treatment and Research
https://read.qxmd.com/read/37974414/bernard-bornstein-1900-1977-his-life-and-contribution-to-polish-and-israeli-neurology
#36
JOURNAL ARTICLE
Avi Ohry, Filip Marcinowski
Bernard Bornstein (1900-1975) was one of a few Polish-Jewish neurologists who escaped the tragic fate of Jews in Nazi-occupied Poland. Educated at the University of Vienna and practicing until the war in Cracow, Bornstein in his scientific work dealt comprehensively with various neurological topics, bringing to Israeli medicine the best of pre-War European neurological diagnostics and combining them with the latest achievements of genetics. He was a teacher of many prominent Israeli neurologists. On the basis of previously unknown archival sources, the fate of Bornstein and his family during World War II was reconstructed...
November 16, 2023: Journal of Medical Biography
https://read.qxmd.com/read/37969326/a-highly-sensitive-indirect-enzyme-linked-immunosorbent-assay-elisa-based-on-a-monoclonal-antibody-specific-to-thermal-stable-soluble-protein-in-pork-fat-for-the-rapid-detection-of-pork-fat-adulterated-in-heat-processed-beef-meatballs
#37
JOURNAL ARTICLE
Sol-A Kim, Jeong-Eun Lee, Dong-Hyun Kim, Song-Min Lee, Hee-Kyeong Yang, Won-Bo Shim
Processed foods containing pork fat tissue to improve flavor and gain economic benefit may cause severe issues for Muslims, Jews, and vegetarians. This study aimed to develop an indirect enzyme-linked immunosorbent assay (iELISA) based on a monoclonal antibody specific to thermal stable-soluble protein in pork fat tissue and apply it to detect pork fat tissue in heat-processed (autoclave, steam, roast, and fry) beef meatballs. To develop a sensitive iELISA, the optimal sample pre-cooking time, coating conditions, primary and secondary dilution time, and various buffer systems were tested...
November 2023: Food science of animal resources
https://read.qxmd.com/read/37964557/racial-ethnic-and-socioeconomic-disparities-in-colorectal-cancer-screening-in-a-large-organization-with-universal-insurance-before-and-during-the-coronavirus-disease-2019-pandemic
#38
JOURNAL ARTICLE
Zohar Levi, Naim Abu-Frecha, Doron Comanesther, Tania Backenstein, Arnon D Cohen, Sapir Eizenstein, Anath Flugelman, Orly Weinstein
OBJECTIVES: Israel is regarded as a country with a developed economy and a moderate income inequality index. In this population-based study, we aimed to measure the inequalities in colorectal cancer screening within Clalit Health, an organization with universal insurance, before and during the coronavirus disease 2019 pandemic. SETTING: Retrospective analysis within Clalit Health Services, Israel. METHODS: We evaluated the rate of being up to date with screening (having a colonoscopy within 10 years or a fecal occult blood test within 1 year) and the colonoscopy completion rate (having a colonoscopy within 6 months of a positive fecal occult blood test) among subjects aged 50-75 in 2019-2021...
November 14, 2023: Journal of Medical Screening
https://read.qxmd.com/read/37941861/genotype-mutations-in-palestinian-children-with-familial-mediterranean-fever-clinical-profile-and-response-to-colchicine-treatment-a-retrospective-cohort-study
#39
JOURNAL ARTICLE
Oadi N Shrateh, Mariam Thalji, Afnan W M Jobran, Aml M Brakat, Abdelrahman M Attia, Fawzy M Abunejma
BACKGROUND: Familial Mediterranean fever is a hereditary autoinflammatory disease affecting mainly Arabs, Turks, Armenians, and Jews with genotype-phenotype heterogeneity, presenting as recurrent episodes of fever along with polyserositis and rash. To date, more than 370 mutations in the MEFV gene have been recognized to cause the disease. METHODS: We conducted a retrospective cohort study involving 124 patients in Hebron, Palestine, diagnosed with FMF at the Al-Ahli, and Palestinian Red Crescent Society (PRCS) Hospitals...
September 2023: Mediterranean journal of rheumatology
https://read.qxmd.com/read/37927580/-you-left-a-void-that-we-will-never-be-able-to-fill-the-legacy-of-edmond-amran-el-maleh-in-a-contemporary-moroccan-novella
#40
JOURNAL ARTICLE
Fernanda Fischione
The sudden depart of a large portion of the Moroccan Jewish population between 1948 and 1967 left a void in Moroccan society, to the extent that some scholars account for the existence of a "double trauma" - a trauma for both those who left for Israel and the Moroccan society at large. This profound social wound has never healed. The Moroccan Jewish intellectual Edmond Amran El Maleh (1917-2010) is the hero of the novella Aḥǧiyat Idmūn 'Amrān al-Māliḥ (The riddle of Edmond Amran El Maleh) by Mohammed Said Hjiouij ( 2020), which this article analyses...
2023: Open Res Eur
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