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https://www.readbyqxmd.com/read/27924612/proteomic-analysis-of-dental-tissue-microsamples
#1
Jonathan E Mangum, Jew C Kon, Michael J Hubbard
Improved understanding of dental enamel development will benefit not only dentistry but also biomedicine more generally. Rat and mouse models of enamel development are relatively well characterized and experimentally powerful. However, the diminutive size of murine teeth makes them difficult to study using standard proteomics approaches. Here, we describe gel-based proteomic methods that enable parallel quantification, identification, and functional characterization of proteins from developing rat and mouse teeth...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27906637/prevalence-of-urat1-allelic-variants-in-the-roma-population
#2
Blanka Stiburkova, Dana Gabrikova, Pavel Čepek, Pavel Šimek, Pavol Kristian, Elizabeth Cordoba-Lanus, Felix Claverie-Martin
The Roma represents a transnational ethnic group, with a current European population of 8-10 million. The evolutionary process that had the greatest impact on the gene pool of the Roma population is called the founder effect. Renal hypouricemia (RHUC) is a rare heterogenous inherited disorder characterized by impaired renal urate reabsorption. The affected individuals are predisposed to recurrent episodes of exercise-induced nonmyoglobinuric acute kidney injury and nephrolithiasis. To date, more than 150 patients with a loss-of-function mutation for the SLC22A12 (URAT1) gene have been found, most of whom are Asians...
December 2016: Nucleosides, Nucleotides & Nucleic Acids
https://www.readbyqxmd.com/read/27906198/population-screening-for-brca1-brca2-mutations-lessons-from-qualitative-analysis-of-the-screening-experience
#3
Sari Lieberman, Amnon Lahad, Ariela Tomer, Carmit Cohen, Ephrat Levy-Lahad, Aviad Raz
PURPOSE: Population screening for BRCA1/BRCA2. mutations is being considered for Ashkenazi Jews (AJ) because 2.5% carry recurrent deleterious mutations and effective cancer prevention exists. This study aimed to provide a qualitative focus on perspectives of individuals, particularly carriers, who were tested through a screening trial. In this trial, the pretest process included only written information. METHODS: Interviews were performed with 26 carriers and 10 noncarriers who participated in a BRCA population screening trial for AJ...
December 1, 2016: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/27906166/which-brca-genetic-testing-programs-are-ready-for-implementation-in-health-care-a-systematic-review-of-economic-evaluations
#4
Elvira D'Andrea, Carolina Marzuillo, Corrado De Vito, Marco Di Marco, Erica Pitini, Maria Rosaria Vacchio, Paolo Villari
PURPOSE: There is considerable evidence regarding the efficacy and effectiveness of BRCA genetic testing programs, but whether they represent good use of financial resources is not clear. Therefore, we aimed to identify the main health-care programs for BRCA testing and to evaluate their cost-effectiveness. METHODS: We performed a systematic review of full economic evaluations of health-care programs involving BRCA testing. RESULTS: Nine economic evaluations were included, and four main categories of BRCA testing programs were identified: (i) population-based genetic screening of individuals without cancer, either comprehensive or targeted based on ancestry; (ii) family history (FH)-based genetic screening, i...
December 2016: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/27905934/estimation-of-country-specific-and-global-prevalence-of-male-circumcision
#5
Brian J Morris, Richard G Wamai, Esther B Henebeng, Aaron Ar Tobian, Jeffrey D Klausner, Joya Banerjee, Catherine A Hankins
BACKGROUND: Male circumcision (MC) status and genital infection risk are interlinked and MC is now part of HIV prevention programs worldwide. Current MC prevalence is not known for all countries globally. Our aim was to provide estimates for country-specific and global MC prevalence. METHODS: MC prevalence data were obtained by searches in PubMed, Demographic and Health Surveys, AIDS Indicator Surveys, and Behavioural Surveillance Surveys. Male age was ≥15 years in most surveys...
March 1, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27900810/population-based-study-of-attitudes-toward-brca-genetic-testing-among-orthodox-jewish-women
#6
Eve Y Tang, Meghna S Trivedi, Rita Kukufka, Wendy K Chung, Raven David, Leah Respler, Sarah Leifer, Isaac Schechter, Katherine D Crew
Given the high prevalence (1 in 40) of BRCA1 and BRCA2 mutations among Ashkenazi Jews, population-based BRCA genetic testing in this ethnic subgroup may detect more mutation carriers. We conducted a cross-sectional survey among Orthodox Jewish women in New York City to assess breast cancer risk, genetic testing knowledge, self-efficacy, perceived breast cancer risk and worry, religious and cultural factors affecting medical decision-making. We used descriptive statistics and multivariable logistic regression models to identify predictors of genetic testing intention/uptake...
November 30, 2016: Breast Journal
https://www.readbyqxmd.com/read/27881842/the-investigation-of-the-origin-of-southern-tunisians-using-hla-genes
#7
Abdelhafidh Hajjej, Wassim Y Almawi, Lasmar Hattab, Amel El-Gaaied, Slama Hmida
The south of Tunisia is characterized by marked ethnic diversity, highlighted by the coexistence of native Berbers with Blacks, Jews and Arab-speaking populations. Despite this heterogeneity, genetic anthropology studies investigating the origin of current Southern Tunisians were rarely reported. We examined human leukocyte antigen (HLA) class I (A, B) and class II (DRB1, DQB1) gene profiles of 250 unrelated Southern Tunisians, and compared them with those of Arab-speaking communities, along with Mediterranean and sub-Sahara African populations using genetic distances, neighbor-joining dendrograms, correspondence and haplotype analysis...
November 24, 2016: Journal of Human Genetics
https://www.readbyqxmd.com/read/27863357/cardiovascular-health-among-two-ethnic-groups-living-in-the-same-region-a-population-based-study
#8
Michal Benderly, Angela Chetrit, Havi Murad, Kathleen Abu-Saad, Michal Gillon-Keren, Ori Rogowski, Ben-Ami Sela, Hannah Kanety, Dror Harats, Ahmed Atamna, Gershon Alpert, Uri Goldbourt, Ofra Kalter-Leibovici
BACKGROUND: Poor cardiovascular health (CVH) among ethnic/racial minorities, studied primarily in the USA, may reflect lower access to healthcare. We examined factors associated with minority CVH in a setting of universal access to healthcare. METHODS AND RESULTS: CVH behaviors and factors were evaluated in a random population sample (551 Arabs, 553 Jews) stratified by sex, ethnicity and age. More Jews (10%) than Arabs (3%) had 3 ideal health behaviors. Only one participant had all four...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27862104/the-influence-of-helicobacter-pylori-on-the-ethnic-distribution-of-barrett-s-metaplasia
#9
A Sonnenberg, K O Turner, S J Spechler, R M Genta
BACKGROUND: Environmental risk factors associated with ethnicity may contribute to the occurrence of Barrett's metaplasia. AIM: Our aim was to investigate the interaction between ethnicity and Helicobacter pylori infection in the occurrence of Barrett's metaplasia among patients undergoing oesophago-gastro-duodenoscopy. METHODS: The Miraca Life Sciences Database is an electronic repository of histopathological patient records. A case-control study evaluated the influence of age, gender, ethnicity and histological diagnosis of H...
November 9, 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27849675/brachioradialis-tendon-coverage-in-volar-distal-radius-plating
#10
Nicholas B Jew, John W Karl, Evan Trupia, Robert J Strauch, James H Calandruccio
Volar plate fixation of unstable distal radius fractures has become the preferred technique by most surgeons for the operative treatment of displaced distal radius fractures. Flexor tendon rupture is a rare but serious complication associated with this operation that is thought to be due to irritation of the flexor tendons over the prominent distal edge of the plate. We describe a novel technique of using the brachioradialis tendon to cover the distal edge of the plate to help prevent tendon irritation and rupture...
December 2016: Techniques in Hand & Upper Extremity Surgery
https://www.readbyqxmd.com/read/27843359/a-new-laryngeal-mask-supraglottic-airway-device-with-integrated-balloon-line-a-descriptive-and-comparative-bench-study
#11
YingHai Zhou, Korinne Jew
Laryngeal masks are invasive devices for airway management placed in the supraglottic position. The Shiley™ laryngeal mask (Shiley™ LM) features an integrated inflation tube and airway shaft to facilitate product insertion and reduce the chance of tube occlusion when patients bite down. This study compared the Shiley LM to two other disposable laryngeal mask devices, the Ambu(®) AuraStraight™ and the LMA Unique™. Overall device design, tensile strength, flexibility of various structures, and sealing performance were measured...
2016: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/27822349/implementation-of-laparoscopic-surgery-for-endometrial-cancer-work-in-progress
#12
REVIEW
H N Sallam, N H Sallam
Human response to new developments regarding birth, death, marriage and divorce is largely shaped by religious beliefs. When assisted reproduction was introduced into medical practice in the last quarter of the twentieth century, it was fiercely attacked by some religious groups and highly welcomed by others. Today, assisted reproduction is accepted in nearly all its forms by Judaism, Hinduism and Buddhism, although most Orthodox Jews refuse third party involvement. On the contrary assisted reproduction is totally unacceptable to Roman Catholicism, while Protestants, Anglicans, Coptic Christians and Sunni Muslims accept most of its forms, which do not involve gamete or embryo donation...
March 28, 2016: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/27793658/best-practices-for-design-and-implementation-of-human-clinical-trials-studying-dietary-oils
#13
REVIEW
Dylan S Mackay, Stephanie Jew, Peter J H Jones
Dietary oils are a significant contributor to overall energy and fatty acid intakes. Changes in the amount and/or type of dietary oils consumed have the potential to impact human health. Clinical trials represent the gold standard for testing the health impacts of such changes in dietary oils. The objective of this review is to explore best practices for clinical trials examining impacts of dietary oils including 1) pre-clinical topics such as research question generation, study design, participant population, outcome measures and intervention product selection and/or preparation; 2) clinical trial implementation topics such as recruitment, trial management, record keeping and compliance monitoring; and 3) post-clinical trial topics dealing with sample analysis and storage as well as management, publication and data access...
October 26, 2016: Progress in Lipid Research
https://www.readbyqxmd.com/read/27790935/pharmacogenetics-and-ethnicity-relevance-for-clinical-implementation-clinical-trials-pharmacovigilance-and-drug-regulation-in-latin-america
#14
Martha Sosa-Macías, Enrique Teran, William Waters, Martha M Fors, Catalina Altamirano, Helgi Jung-Cook, Carlos Galaviz-Hernández, Marisol López-López, Diadelis Remírez, Graciela E Moya, Francisco Hernández, Humberto Fariñas, Ronald Ramírez, Carolina Céspedes-Garro, Eduardo Tarazona-Santos, Adrián LLerena
Congress of Pharmacogenetics and Personalized Medicine. Ethnicity, clinical implementation and regulatory environment (MESTIFAR 2016 Quito). Quito, Ecuador, 19-21 May 2016. The Ibero-American Network of Pharmacogenetics and Pharmacogenomics (RIBEF) was created in 2006 with the main aim of promoting personalized medicine and collaborative pharmacogenetics research in Spanish- and Portuguese-speaking countries in America and the Iberian Peninsula. The final goal of this initiative was the inclusion of Latin American populations that may benefit from the implementation of personalized medicine in drug therapy...
October 28, 2016: Pharmacogenomics
https://www.readbyqxmd.com/read/27771472/haplotype-analysis-of-%C3%AE-thalassemia-chromosomes-reveals-heterogeneity-and-multiple-founders-in-ashkenazi-jews
#15
Adir Shaulov, Dvora Filon, Deborah Rund
α-Thalassemia (α-thal) is among the world's most common single gene disorders, generally attributed to a selective advantage of heterozygotes against malaria mortality. A high frequency of -α(3.7) deletion heterozygosity has been previously reported in Ashkenazi Jews despite lack of obvious malarial selection pressure in this population. Using haplotype and -α(3.7) subtype analysis we analyzed a subset of -α(3.7) homozygotes from various Israeli ethnic groups. We found a high frequency of the common Ia haplotype in Yemenite Jews and Arabs (54% and 13% respectively)...
October 19, 2016: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/27764964/human-dignity-and-autonomy-in-the-care-for-patients-with-dementia-differences-among-formal-caretakers-from-various-cultural-backgrounds
#16
Miriam Ethel Bentwich, Nomy Dickman, Amitai Oberman
OBJECTIVES: To explore whether gaps exist between caretakers from different ethno-cultural groups (Israeli-born Jews [Sabras], Israeli Arabs [Arabs], and migrants from Russia [Russians]) regarding their perceptions of autonomy and human dignity of patients with dementia. DESIGN: A mixed-methods research scheme was used, comprised of qualitative and quantitative methods, utilizing semi-structured interviews and self-reported questionnaires. Twenty formal caretakers participated in the qualitative portion, and approximately 200 caretakers were included in the quantitative portion...
October 21, 2016: Ethnicity & Health
https://www.readbyqxmd.com/read/27744417/lower-circulating-insulin-like-growth-factor-i-is-associated-with-better-cognition-in-females-with-exceptional-longevity-without-compromise-to-muscle-mass-and-function
#17
Leland Perice, Nir Barzilai, Joe Verghese, Erica F Weiss, Roee Holtzer, Pinchas Cohen, Sofiya Milman
Mutations that reduce somatotropic signaling result in improved lifespan and health-span in model organisms and humans. However, whether reduced circulating insulin-like growth factor-I (IGF-I) level is detrimental to cognitive and muscle function in older adults remains understudied. A cross-sectional analysis was performed in Ashkenazi Jews with exceptional longevity (age ≥95 years). Cognition was assessed using the Mini-Mental State Examination and muscle function with the chair rise test, grip-strength, and gait speed...
October 14, 2016: Aging
https://www.readbyqxmd.com/read/27735926/experiences-from-a-pilot-program-bringing-brca1-2-genetic-screening-to-theus-ashkenazi-jewish-population
#18
Chana Wiesman, Esther Rose, Allison Grant, Adam Zimilover, Susan Klugman, Nicole Schreiber-Agus
PURPOSE: The notion of offering population-based screening to the Ashkenazi Jewish (AJ) population for the BRCA1/2 founder mutations continues to gain support. A program called the BRCAcommunity initiative was designed to identify the benefits and barriers associated with implementing this screening in a clinical setting. METHODS: Interested AJ individuals were stratified into high-risk (HR) and low-risk (LR) groups based on self-reported cancer histories. Those at HR were offered traditional genetic counseling/testing; those at LR were offered group genetic counseling and subsidized AJ BRCA founder mutation testing...
October 13, 2016: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/27733901/hyperemesis-gravidarum-in-northern-israel-a-retrospective-epidemiological-study
#19
Tom Konikoff, Tehila Avraham, Ella Ophir, Jacob Bornstein
BACKGROUND: Hyperemesis gravidarum (HG) is characterized by severe intractable nausea and vomiting in pregnancy leading to electrolyte imbalance, ketonuria, and weight loss. The cause is unknown. This study sought to investigate the prevalence and characteristics of HG in the Western Galilee in two ethnic populations and to estimate its economic burden. METHODS: Data on ethnicity, age, gestational age, number of pregnancies, and length of hospitalization were collected from the medical files of all women with HG admitted to the Galilee Medical Center in 2010-2013...
2016: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/27732010/parental-ethnic-racial-socialization-and-social-attitudes-among-ethnic-racial-minority-and-white-american-emerging-adults
#20
Alisia G T T Tran, Jeffrey S Mintert, Gilbert B Jew
This article utilizes moderated mediation analyses to explore whether the relations between parental ethnic-racial socialization (PERS) dimensions and social attitudes differ across ethnic-racial minority (n = 128) and White (n = 131) college-going emerging adults. We examined social dominance orientation (SDO) as an index of antiegalitarian intergroup attitudes and attitudes toward interpersonal harmony as an index of interpersonal attitudes. We tested whether there were ethnic-racial variations in mediation models in which each type of PERS dimension was expected to be linked to greater antiegalitarian attitudes (greater SDO), which, in turn, was predicted to be associated with less prosocial attitudes (lower harmony enhancement)...
August 15, 2016: American Journal of Orthopsychiatry
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