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https://www.readbyqxmd.com/read/26282424/functional-analysis-of-a-bacitracin-resistance-determinant-located-on-icecp1-a-novel-tn916-like-element-from-a-conjugative-plasmid-in-clostridium-perfringens
#1
Xiaoyan Han, Xiang-Dang Du, Luke Southey, Dieter M Bulach, Torsten Seemann, Xu-Xia Yan, Trudi L Bannam, Julian I Rood
Bacitracins are mixtures of structurally related cyclic polypeptides with antibiotic properties. They act by interfering with the biosynthesis of the bacterial cell wall. In this study, we analyzed an avian necrotic enteritis strain of Clostridium perfringens that was resistant to bacitracin and produced NetB toxin. We identified a bacitracin resistance locus that resembled a bacitracin resistance determinant from Enterococcus faecalis. It contained the structural genes bcrABD and a putative regulatory gene, bcrR...
November 2015: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/25795795/o1-1discovering-selective-anticancer-drugs-succeeding-slowly-is-better-than-failing-fast
#2
A H Calvert
Most of the first generation of anticancer drugs act by preventing cellular proliferation. The fact that can induce remissions in the tumour without lethal toxicity to the patient is, at first sight, surprising. However anti-proliferative agents have been the mainstay of cancer treatment for 60 years and continue to play a major role. Perhaps we should view their lack of toxicities to non-proliferating tissues as an advantage rather than seeing only that their toxicity to proliferating tissues is a problem...
March 2015: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/25613804/pilot-scale-study-on-nitrogen-and-aromatic-compounds-removal-in-printing-and-dyeing-wastewater-by-reinforced-hydrolysis-denitrification-coupling-process-and-its-microbial-community-analysis
#3
Chao Li, Hongqiang Ren, Erqin Yin, Siyuan Tang, Yi Li, Jiashun Cao
Aiming to efficiently dispose printing and dyeing wastewater with "high organic nitrogen and aromatic compounds, but low carbon source quality", the reinforced anaerobic hydrolysis-denitrification coupling process, based on improved UASB reactors and segregated collection-disposition strategy, was designed and applied at the pilot scale. Results showed that the coupling process displayed efficient removal for these two kinds of pollutants (nitrogen and aromatics), since the concentration of NH3-N (shortened as ρ (NH3-N)) < 8 mg/L, ρ (TN) < 15 mg/L with long-term stability for the effluent, and both species and abundances of aromatics reduced greatly by UASBs according to GC-MS...
June 2015: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/24605135/management-of-borderline-ovarian-tumours-a-comprehensive-review-of-the-literature
#4
REVIEW
Alejandra Abascal-Saiz, Laura Sotillo-Mallo, Javier de Santiago, Ignacio Zapardiel
Borderline ovarian tumours differ from epithelial ovarian cancer by their low incidence, frequent association with infertility, low association with mutations in BCRA genes, different percentages of the most common histological types, early stage diagnosis, and high survival rate, even when associated with peritoneal involvement. They occur in younger women, which is why one of the objectives in these patients will be the preservation of fertility. The management of these tumours has been widely discussed and still continues to be controversial...
2014: Ecancermedicalscience
https://www.readbyqxmd.com/read/24289593/breast-cancer-risk-and-early-diagnosis-applications-in-turkish-women-aged-50-and-over
#5
Esin Ceber, Gulengul Mermer, Figen Okcin, Dilek Sari, Mahide Demireloz, Aysun Eksioglu, Filiz Ogce, Dilek Cakir, Gulsun Ozenturk
BACKGROUND: The aim of the study was to determine breast cancer risk and early diagnosis applications in women aged ≥50. MATERIALS AND METHODS: This cross-sectional, descriptive field study focused on a population of 4,815 in Mansurog?lu with a 55.1% participation rate in screening. In the study, body mass index (BMI) was also evaluated in the calculation of breast cancer risk by the Breast Cancer Risk Assessment Tool (BCRA) (also called the "Gail Risk Assessment Tool") ...
2013: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/22941078/antimicrobial-susceptibility-of-bacillus-strains-isolated-from-primary-starters-for-african-traditional-bread-production-and-characterization-of-the-bacitracin-operon-and-bacitracin-biosynthesis
#6
David B Adimpong, Kim I Sørensen, Line Thorsen, Birgitte Stuer-Lauridsen, Warda S Abdelgadir, Dennis S Nielsen, Patrick M F Derkx, Lene Jespersen
Bacillus spp. are widely used as feed additives and probiotics. However, there is limited information on their resistance to various antibiotics, and there is a growing concern over the transfer of antibiotic resistance genes. The MIC for 8 antibiotics was determined for 85 Bacillus species strains, Bacillus subtilis subsp. subtilis (n = 29), Bacillus licheniformis (n = 38), and Bacillus sonorensis (n = 18), all of which were isolated from starters for Sudanese bread production. All the strains were sensitive to tetracycline (8...
November 2012: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/22037338/comparison-of-breast-cancer-risk-estimations-risk-perception-and-screening-behaviors-in-obese-rural-korean-women
#7
COMPARATIVE STUDY
SoMi Park, Barbara B Cochrane, Sang Baek Koh, ChaeWeon Chung
PURPOSE/OBJECTIVES: To assess three breast cancer risk assessment tools in obese rural Korean women. DESIGN: Cross-sectional survey design. SETTING: Community settings in the rural region of northeastern South Korea. SAMPLE: A nested cohort sample of 64 severely obese women aged 40-60 years from the Korean Genomic Regional Cohort registry. METHODS: The Breast Cancer Risk Assessment Tool of the National Cancer Institute (BCRAT-NCI), Breast Cancer Risk Appraisal for Korean Women (BCRA-K), and Estimation of Individualized Probabilities of Developing Breast Cancer for Korean Women (EIPDBC-K) were used for interview data...
November 2011: Oncology Nursing Forum
https://www.readbyqxmd.com/read/22004810/multiple-antibiotic-resistance-of-enterococcus-faecalis-and-enterococcus-faecium-from-cecal-contents-in-broiler-chicken-and-turkey-flocks-slaughtered-in-canada-and-plasmid-colocalization-of-teto-and-ermb-genes
#8
Cindy-Love Tremblay, Ann Letellier, Sylvain Quessy, Martine Boulianne, Danielle Daignault, Marie Archambault
This study was conducted to characterize the antimicrobial resistance determinants and investigate plasmid colocalization of tetracycline and macrolide genes in Enterococcus faecalis and Enterococcus faecium from broiler chicken and turkey flocks in Canada. A total of 387 E. faecalis and E. faecium isolates were recovered from poultry cecal contents from five processing plants. The percentages of resistant E. faecalis and E. faecium isolates, respectively, were 88.1 and 94% to bacitracin, 0 and 0.9% to chloramphenicol, 0...
October 2011: Journal of Food Protection
https://www.readbyqxmd.com/read/21908673/transcriptional-profiling-analysis-of-the-global-regulator-norg-a-gntr-like-protein-of-staphylococcus-aureus
#9
Q C Truong-Bolduc, P M Dunman, T Eidem, D C Hooper
The GntR-like protein NorG has been shown to affect Staphylococcus aureus genes involved in resistance to quinolones and β-lactams, such as those encoding the NorB and AbcA transporters. To identify the target genes regulated by NorG, we carried out transcriptional-profiling assays using S. aureus RN6390 and its isogenic norG::cat mutant. Our data showed that NorG positively affected the transcription of global regulators mgrA, arlS, and sarZ. The three putative drug efflux pump genes most positively affected by NorG were the NorB efflux pump (5...
November 2011: Journal of Bacteriology
https://www.readbyqxmd.com/read/21718651/-genetic-predisposition-to-breast-and-ovarian-cancer-importance-of-test-results
#10
REVIEW
Claire Julian-Reynier
Oncogenetic consultations and predictive BRCA1/2 testing are intertwined processes and the specific impact of these genetic tests if performed alone through direct-to-consumer offers remains unknown. Noteworthy, the expectations of patients vary with their own status, whether they are affected or not by breast cancer at the time genetic testing is performed. The prescription of genetic tests for BCRA mutations has doubled in France between 2003 and 2009. There is a consensus on the fact that genetic results disclosure led to a significant increase in the knowledge and understanding that the patients have of the genetic risk and also changed the medical follow-up of these patients...
June 2011: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/21365914/-diversity-and-quantification-analysis-of-functional-genes-in-a-lab-scale-denitrifying-quinoline-degrading-bioreactor
#11
Xi Xia, Xiaojun Zhang, Huyuan Feng, Liping Zhao
OBJECTIVE: In order to study the diversity and distribution of Benzoyl coenzyme A reductase (bcrA) and oxygenase components of 1H-2-oxoquinoline 8-monooxygenase (oxoO) gene in a lab scale denitrifying bioreactors for treating quinoline-containing wastewater. METHODS: Genomic microbial DNA was extracted from the biofilm samples of bioreactor. Based on the known oxoO genes sequences in GenBank, we designed primers for oxoO gene amplification. Using our designed oxoO gene primers and a pair of degenerate primers of bcrA gene obtained from literature, we amplified the DNA samples...
December 2010: Wei Sheng Wu Xue Bao, Acta Microbiologica Sinica
https://www.readbyqxmd.com/read/21349382/-ovarian-epithelial-dysplasia-description-of-a-dysplasia-scoring-scheme
#12
COMPARATIVE STUDY
Gautier Chene, Jacques Dauplat, Ines Raoelfils, Yves-Jean Bignon, Anne Cayre, Patricia Jaffeux, Bruno Aublet-Cuvelier, Christophe Pomel, Frédérique Penault-Llorca
INTRODUCTION: Precancerous ovarian epithelial dysplasia was first described after prophylactic oophorectomy (OP) for genetic risk (BRCA mutation) or because of a strong family history of ovarian and/or breast cancer. The objective of this study was to describe histopathological features of ovarian dysplasia and to propose a dysplasia scoring sheme with a cut-off. PATIENTS AND METHOD: One hundred and twenty-five bilateral oophorectomies (genetic predisposition: n=35 and control group: n=90) were reviewed by two pathologists blinded to clinical data...
February 2011: Annales de Pathologie
https://www.readbyqxmd.com/read/21196340/stics-scouts-and-p53-signatures-a-new-language-for-pelvic-serous-carcinogenesis
#13
REVIEW
Karishma Mehra, Mitra Mehrad, Geng Ning, Ronny Drapkin, Frank D McKeon, Wa Xian, Christopher P Crum
The events leading to the most common and most lethal ovarian carcinoma - high grade serous carcinoma - have been poorly understood. However, the detailed pathologic study of asymptomatic women with germ-line BRCA 1 or BRCA2 (BCRA+) mutations has unearthed an early malignancy, serous tubal intraepithelial carcinomas (STIC), which has linked many peritoneal and ovarian serous carcinomas to the fimbria. The distinction between high-grade serous and endometrioid carcinomas continues to narrow, with shared alterations in expression of pTEN, PAX2 and p53...
2011: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/19602149/direct-stimulus-perception-and-transcription-activation-by-a-membrane-bound-dna-binding-protein
#14
Susanne Gebhard, Ahmed Gaballa, John D Helmann, Gregory M Cook
Few membrane proteins with a role in transcriptional regulation have been studied, and none are able to perceive their respective stimuli and activate transcription of their regulons without the aid of auxiliary proteins. The bacitracin resistance regulator, BcrR, of Enterococcus faecalis is a membrane-bound DNA binding protein and is required for bacitracin-dependent expression of the bacitracin resistance genes, bcrABD. Here, we show that BcrR interacts directly with Zn2+ bacitracin (Kd = 2-5 micropM), but not metal-free bacitracin...
August 2009: Molecular Microbiology
https://www.readbyqxmd.com/read/19449117/bulbocavernosus-reflex-testing-a-preliminary-study-on-the-prognostic-factors-for-potency-and-response-to-sildenafil-citrate-after-bilateral-nerve-sparing-radical-prostatectomy
#15
Shai Shefi, Manuel Zwecker, Jehonathan H Pinthus, Yoram Mor, Gabriel Zeilig, Yeheskell Shemesh, Jacob I Hanani, Gil Raviv
OBJECTIVE: Erectile dysfunction (ED) following radical prostatectomy is of major concern for both patients and caring physicians. We evaluated the bulbocavernosus reflex latency (BCRL) and amplitude (BCRA) following bilateral nerve-sparing radical retropubic prostatectomy (NS-RRP) to predict the response to sildenafil citrate (SC). METHODS: Patients were recruited in our ED clinic following NS-RRP. Exclusion criteria included preoperative significant ED, neurological disease, and nitrates treatment...
March 2010: International Urology and Nephrology
https://www.readbyqxmd.com/read/19304435/strains-of-burkholderia-cenocepacia-genomovar-iiia-possessing-the-cbla-gene-that-are-distinct-from-et12
#16
Jane F Turton, Emily O'Brien, Brian Megson, Mary E Kaufmann, Tyrone L Pitt
Three strains of Burkholderia cenocepacia genomovar IIIA that were polymerase chain reaction positive for cblA, bcrA, and the epidemic strain marker, but were distinct from representatives of ET12 by pulsed-field gel electrophoresis, are described. One of these strains was shown to express cable pili by electron microscopy.
May 2009: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/19004392/microbial-water-quality-and-influences-of-fecal-accumulation-from-a-dog-exercise-area
#17
Lynell Garfield, Mark Walker
The risk of water contamination by fecal bacteria may be increased if a watershed includes areas where feces accumulate as a result of specific land uses, such as areas where owners frequently exercise dogs. This study examined the effects of a year-round dog exercise area in the Burke Creek Recreational Area (BCRA) in the arid alpine environment of Stateline, Nevada. Burke Creek drains a small, high relief watershed, flows through a sedimentation basin in the BCRA, and enters Lake Tahoe. Over the course of 14 months, we analyzed water samples from the creek for Escherichia coli and collected feces from plots to estimate fecal accumulation...
November 2008: Journal of Environmental Health
https://www.readbyqxmd.com/read/18481184/elicitation-effects-of-oligosaccharides-on-the-transcriptional-level-of-bacitracin-abc-transporter-genes-in-bacillus-licheniformis
#18
Tania Murphy, Ipsita Roy, Anthony Harrop, Keith Dixon, Tajalli Keshavarz
Bacitracin ABC transporter comprises a self-resistance system in Bacillus licheniformis against its own product (bacitracin). Elicitation effects of carbohydrates on transcription level of bcrABC genes encoding bacitracin ABC transporter system were investigated through quantification by real-time PCR. Increases of 68% and 29% in bacitracin A yields after 36 h were achieved in cultures supplemented with oligoguluronate and oligoguluronate/mannan oligosaccharide combination. Cultures with combined elicitors showed 3, 2...
September 2008: Biotechnology Letters
https://www.readbyqxmd.com/read/18227063/molecular-analysis-of-bcrr-a-membrane-bound-bacitracin-sensor-and-dna-binding-protein-from-enterococcus-faecalis
#19
Jonathan C Gauntlett, Susanne Gebhard, Stefanie Keis, Janet M Manson, Klaas M Pos, Gregory M Cook
BcrR has been identified as a novel regulatory protein of high level bacitracin resistance encoded by the bcrABD operon in Enterococcus faecalis. The N-terminal domain of BcrR has similarity to the helix-turn-helix motif of DNA-binding proteins, and topological modeling predicts that the C-terminal domain contains four transmembrane alpha-helices. These data have led to the hypothesis that BcrR functions as both a membrane-bound sensor and transducer of bacitracin availability to regulate bcrABD expression...
March 28, 2008: Journal of Biological Chemistry
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