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JOURNAL ARTICLE
Tamer Sakaci, Elbis Ahbap, Taner Basturk, Mustafa Ortaboz, Ayse Aysim Ozagari, Emrah Erkan Mazı, Kamile Gulcin Eken, Nuri Baris Hasbal, Abdulkadir Unsal
BACKGROUND: Diabetic nephropathy is one of the most common complications associated with diabetes. However, non-diabetic kidney disease has been reported in patients with type 2 diabetes at varying incidence rates. The objective of our study is to investigate the occurrence, clinicopathological characteristics, and inflammatory markers linked to diabetic and non-diabetic nephropathy (NDN) in patients with type 2 diabetes mellitus (DM). Additionally, we aimed to explore the possibility of identifying non-diabetic pathology using different biopsy indications...
March 3, 2024: Clinical Nephrology
#22
REVIEW
Pedro Alves Soares Vaz de Castro, Arthur Aguiar Amaral, Mariana Godinho Almeida, Haresh Selvaskandan, Jonathan Barratt, Ana Cristina Simões E Silva
BACKGROUND: IgA nephropathy (IgAN) is a common primary glomerular disease. The O-glycosylation status of IgA1 plays a crucial role in disease pathophysiology. The level of poorly-O-galactosylated IgA1, or galactose-deficient IgA1 (Gd-IgA1), has also been identified as a potential biomarker in IgAN. We sought to examine the value of serum Gd-IgA1 as a biomarker in IgAN, by investigating its association with clinical, laboratory, and histopathological features of IgAN. METHODS: The review followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations and was registered in PROSPERO (CRD42021287423)...
March 1, 2024: Journal of Nephrology
#23
JOURNAL ARTICLE
Yoichi Iwafuchi, Tetsuo Morioka, Yuko Oyama, Ichiei Narita
We describe a case of full-house nephropathy without any underlying disease, including systemic lupus erythematosus. A 40-year-old woman was referred to our hospital with mild proteinuria and microscopic hematuria. The patient was diagnosed with immune complex-mediated glomerulonephritis with a predominant mesangioproliferative pattern based on renal histopathological results using full-house immunofluorescence staining. She showed no clinical criteria for the diagnosis of systemic lupus erythematosus, except for kidney disorders, and tested negative for antinuclear antibodies throughout her clinical course...
February 29, 2024: CEN Case Reports
#24
REVIEW
Bryce Barr, Sean Barbour
PURPOSE OF REVIEW: As the most common primary glomerulonephritis, immunoglobulin A (IgA) nephropathy (IgAN) is an important cause of kidney failure and mortality. Until recently, therapeutic options were limited. Fortunately, there have been numerous recent clinical trials demonstrating efficacy of new therapies in slowing chronic kidney disease (CKD) progression at varying stages of disease. RECENT FINDINGS: The TESTING trial has provided high-quality evidence for slowing estimated glomerular filtration rate (eGFR) decline with a reduced-dose glucocorticoid regimen, while demonstrating an improved safety profile...
May 1, 2024: Current Opinion in Nephrology and Hypertension
#25
REVIEW
Mark Haas
PURPOSE OF REVIEW: To present findings indicating the value of kidney biopsy in assessing prognosis and guiding clinical approach to patients with IgA vasculitis nephritis (IgAVN), including a recent international study examining the value of the Oxford (MEST-C) classification. RECENT FINDINGS: Historically, kidney biopsies with IgAVN are scored using the International Society for Kidney Diseases in Children (ISKDC) classification. However, this classification has limited prognostic value, and most biopsies fall into just two of the six ISKDC grades...
May 1, 2024: Current Opinion in Nephrology and Hypertension
#26
JOURNAL ARTICLE
Takahide Kimura, Naoki Washida, Shigeaki Ohtsuki, Kazuya Sugita, Kozi Hosoya, Kiyotaka Uchiyama
BACKGROUND: The effects of exercise therapy (ET) on renal function in chronic kidney disease (CKD) remain unclear. METHODS: In a randomized controlled trial (UMIN-CTR number: UMIN000038415), we investigated whether ET affects renal function in CKD; eligible patients had undergone renal biopsy in the past 3 months. We stratified patients by disease (immunoglobulin A [IgA] nephropathy, n = 16; diabetic nephropathy, n = 4; benign nephrosclerosis, n = 13; and other CKD types, n = 13) and randomized them to 12 weeks' observation and 24 weeks' ET comprising home-based aerobic exercise 3×/week and resistance training 2×/week (intervention group) or usual care (non-intervention group)...
February 25, 2024: Clinical and Experimental Nephrology
#27
JOURNAL ARTICLE
Yifan Zhu, Haidong He, Weiqian Sun, Jiajun Wu, Yong Xiao, Yinshun Peng, Ping Hu, Meiping Jin, Ping Liu, DongLiang Zhang, Jiajun Wu, Ting Xie, Lusheng Huang, Weiming He, Minggang Wei, Lishun Wang, Xudong Xu, Yuyan Tang
BACKGROUND: IgA nephropathy (IgAN) is a major cause of primary glomerulonephritis characterized by mesangial deposits of galactose-deficient IgA1 (Gd-IgA1). Toll-like receptors (TLRs), particularly TLR4 are involved in the pathogenesis of IgAN. The role of gut microbiota on IgAN patients was recently investigated. However, whether gut microbial modifications of Gd-IgA1 through TLR4 play a role in IgAN remains unclear. METHODS: We recruited subjects into four groups, including 48 patients with untreated IgAN, 22 treated IgAN patients (IgANIT), 22 primary membranous nephropathy (MN), and 31 healthy controls (HCs)...
February 24, 2024: Nephrology, Dialysis, Transplantation
#28
JOURNAL ARTICLE
Charlotte Day, Rachel Shute
No abstract text is available yet for this article.
February 21, 2024: Archives of Disease in Childhood. Education and Practice Edition
#29
JOURNAL ARTICLE
Guizhen Yu, Jie Zhao, Meifang Wang, Yang Chen, Shi Feng, Bingjue Li, Cuili Wang, Yucheng Wang, Hong Jiang, Jianghua Chen
BACKGROUND: IgA vasculitis nephritis is the most common secondary IgA nephropathy. Urinary C4d have been identified associated with the development and progression in primary IgA nephropathy. However, its role in kidney disease progression of IgA vasculitis nephritis is still unclear. METHODS: This study enrolled 139 patients with IgA vasculitis nephritis (IgAVN), 18 healthy subjects, 23 Focal segmental glomerulosclerosis patients and 38 IgA nephropathy (IgAN) patients...
February 19, 2024: Nephrology, Dialysis, Transplantation
#30
JOURNAL ARTICLE
Mickaël Bobot, Sandrine Lemoine
This article aims to summarize the “Quoi de neuf en néphrologie?” session held at the 2023 SFNDT Congress in Liège and sessions focused on updates regarding IgA nephropathy (NIgA) and ANCA-associated vasculitis. The agenda for the nephrology “Quoi de neuf en néphrologie?” session this year was to review key publications from non-nephrology journals, discussing topics such as nephroprotection, treatment of glomerulopathies (IgA and APOL1), clinical trials on arterial hypertension, urinary lithiasis, and other areas of renal physiology, including glomerular filtration rate estimation...
February 12, 2024: Néphrologie & Thérapeutique
#31
JOURNAL ARTICLE
Hassane Moussa Diongolé, Zeinabou Maiga Moussa Tondi, Abdoulazize Garba, Kabirou Ganiou, Laouali Chaibou, Djibrilla Bonkano, Illiassou Aboubacar, Abdoul Aziz Seribah, Abdoul Madjid Abdoulaye Idrissa, Akinfenwa Atanda, Lionel Rostaing
Kidney biopsy (KB) has become essential in the nephrologist's approach to kidney diseases, both for diagnosis, treatment, and prognosis. Our objective is to describe the preliminary results of KBs in Niger, one of the poorest countries in the world. This is a descriptive cross-sectional study that took place over 36 months in the nephrology/dialysis department of the Zinder National Hospital. Biopsy results were obtained in less than 5 working days. Patients were responsible for covering the cost of the kidney biopsy...
January 24, 2024: Journal of Clinical Medicine
#32
JOURNAL ARTICLE
Samar Abd ElHafeez, Anneke Kramer, Mustafa Arici, Miha Arnol, Anders Åsberg, Samira Bell, Julie Belliere, Carmen Díaz Corte, Gema Fernández Fresnedo, Marc Hemmelder, Line Heylen, Kristine Hommel, Julia Kerschbaum, Radomir Naumović, Dorothea Nitsch, Rafael Santamaria, Patrik Finne, Runolfur Palsson, Maria Pippias, Halima Resic, Mai Rosenberg, Carmen Santiuste de Pablos, Mårten Segelmark, Søren Schwartz Sørensen, Maria Jose Soler, Enrico Vidal, Kitty J Jager, Alberto Ortiz, Vianda S Stel
BACKGROUND AND HYPOTHESIS: Primary glomerular disease (PGD) is a major cause of end-stage kidney disease (ESKD) leading to kidney replacement therapy (KRT). We aimed to describe incidence (trends) in individuals starting KRT for ESKD due to PGD and to examine their survival and causes of death. METHODS: We used data from the European Renal Association (ERA) Registry on 69 854 patients who started KRT for ESKD due to PGD between 2000 and 2019. ERA primary renal disease codes were used to define six PGD subgroups...
February 7, 2024: Nephrology, Dialysis, Transplantation
#33
JOURNAL ARTICLE
Shoko Ochiai, Masao Kikuchi, Koichi Kaikita, Shouichi Fujimoto
No abstract text is available yet for this article.
February 6, 2024: Journal of Nephrology
#34
JOURNAL ARTICLE
Hiroshi Yamashita, Masahiro Okabe, Hiroyuki Ueda, Yoichi Miyazaki, Takashi Yokoo
No abstract text is available yet for this article.
January 31, 2024: Clinical Nephrology
#35
JOURNAL ARTICLE
Ryoma Miyasaka, Yukihiro Wada, Kazuhiro Takeuchi, Tetsuya Abe, Ryota Uchitsubo, Sayumi Kawamura, Shun Sakurabayashi, Shokichi Naito, Togo Aoyama, Akira Shimizu, Yasuo Takeuchi
Recently, several target antigens of membranous nephropathy (MN), such as phospholipase A2 receptor (PLA2R) and exostosin 1/exostosin 2 (EXT1/2), have been discovered. A 30-year-old woman was referred to our hospital with nephrotic range proteinuria and microscopic hematuria. She was first noted to have proteinuria before pregnancy, and her proteinuria worsened in the postpartum period. A renal biopsy showed MN. Immunofluorescence microscopy showed IgG, IgA, IgM, C3, C4, and C1q depositions in the mesangial area and glomerular capillary walls (GCWs)...
January 27, 2024: CEN Case Reports
#36
JOURNAL ARTICLE
Yinhong Wang, Hao Wang, Xiaotao Ma, Zikun Zhu, Xuefei Tian, Rongguo Fu, Lining Jia
BACKGROUND: The objective of this study is to investigate the clinical and pathological differences between patients with IgA nephropathy (IgAN) and IgA vasculitis associated nephritis (IgAVN). METHODS: A total of 253 patients with IgAN and 71 patients with IgAVN were retrospectively included in the study, and clinical and laboratory data were collected and analysed. RESULTS: Compared with IgAVN group, months from onset to kidney biopsy were significantly prolonged in IgAN patients because of the lack of obvious symptoms such as rash, abdominal symptoms, and joint pain (13...
January 25, 2024: BMC Nephrology
#37
JOURNAL ARTICLE
Hajime Nagasawa, Seiji Ueda, Hitoshi Suzuki, Celia Jenkinson, Yusuke Fukao, Maiko Nakayama, Tomoyuki Otsuka, Teruyuki Okuma, Wilmelenne Clapper, Kai Liu, Mai Nguyen, Radko Komers, Yusuke Suzuki
BACKGROUND: The mechanism leading to the development of IgA nephropathy (IgAN) remains to be completely understood. Endothelin-1 (ET-1) as well as angiotensin II (AngII) promote glomerular injury, tubulointerstitial inflammation, and fibrosis leading to chronic kidney disease. Sparsentan, a dual endothelin angiotensin receptor antagonist (DEARA), recently received accelerated approval in United States for the reduction of proteinuria in adults with IgAN at high risk of disease progression...
January 25, 2024: Nephrology, Dialysis, Transplantation
#38
JOURNAL ARTICLE
Sean J Barbour, Rosanna Coppo, Lee Er, Evangeline Pillebout, Maria Luisa Russo, Charles E Alpers, Agnes B Fogo, Franco Ferrario, J Charles Jennette, Ian S D Roberts, H Terence Cook, Jie Ding, Baige Su, Xuhui Zhong, Fernando C Fervenza, Ladan Zand, Licia Peruzzi, Laura Lucchetti, Ritsuko Katafuchi, Yuko Shima, Norishige Yoshikawa, Daisuke Ichikawa, Yusuke Suzuki, Luisa Murer, Robert J Wyatt, Catherine Park, Raoul D Nelson, JoAnn H Narus, Scott Wenderfer, Duvuru Geetha, Eric Daugas, Renato C Monteiro, Shinya Nakatani, Antonio Mastrangelo, Matti Nuutinen, Mikael Koskela, Lutz T Weber, Agnes Hackl, Martin Pohl, Carmine Pecoraro, Nobuo Tsuboi, Takashi Yokoo, Ito Takafumi, Shouichi Fujimoto, Giovanni Conti, Domenico Santoro, Marco Materassi, Hong Zhang, Sufang Shi, Zhi-Hong Liu, Vladimir Tesar, Dita Maixnerova, Carmen Avila-Casado, Ingeborg Bajema, Antonella Barreca, Jan U Becker, Jessica M Comstock, Virgilius Cornea, Karen Eldin, Loren Herrera Hernandez, Jean Hou, Kensuke Joh, Mercury Lin, Nidia Messias, Andrea Onetti Muda, Fabio Pagni, Francesca Diomedi-Camassei, Heikki Tokola, Maria D'Armiento, Maximilian Seidl, Avi Rosenberg, Aurélie Sannier, Maria Fernanda Soares, Suxia Wang, Caihong Zeng, Mark Haas
BACKGROUND: Nephritis is a common manifestation of IgA vasculitis and is morphologically indistinguishable from IgA nephropathy. While MEST-C scores are predictive of kidney outcomes in IgA nephropathy, their value in IgA vasculitis nephritis has not been investigated in large multiethnic cohorts. METHODS: Biopsies from 262 children and 99 adults with IgA vasculitis nephritis ( N =361) from 23 centers in North America, Europe, and Asia were independently scored by three pathologists...
April 1, 2024: Clinical Journal of the American Society of Nephrology: CJASN
#39
JOURNAL ARTICLE
Hernán Trimarchi, Fernando C Fervenza, Rosanna Coppo
IgA nephropathy is the most common primary glomerulonephritis worldwide, and an important cause of kidney failure, as 20-40% of patients progress to renal replacement therapy 20-30 years after diagnosis. Its clinical presentation ranges from isolated microscopic hematuria to nephrotic syndrome, and even to a rapidly progressive course. Ethnicity and epigenetics play a key role in its clinical aggressiveness. Selection of patients at risk needing immunosuppressive treatment is a challenge for the nephrologist...
January 18, 2024: Journal of Nephrology
#40
JOURNAL ARTICLE
Sophie De Seigneux, Fadi Haidar, David Jaques, Gregoire Masson, Marine Nachit, Patrick Saudan
Molecules such as sparsentan and budesonide look promising to treat proteinuric IGA nephropathy. SLGT2 inhibitors have a prominent place in nephroprotection and could be used in the treatment of acute kidney injury due to heart failure as well. High volume hemodiafiltration compared to hemodialysis improves survival in dialysis patients. Lessening dialysate temperature does not improve hemodynamic stability during the dialysis session. Sodium bicarbonate does not seem to protect renal function in renal transplant patients...
January 17, 2024: Revue Médicale Suisse
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