Read by QxMD icon Read

IgA nephrology

Matthew G Sampson
The discovery of genetic variation associated with pediatric kidney disease has shed light on the biology underlying these conditions and, in some cases, has improved our clinical management of patients. We are challenged to continue the momentum of the genomic era in pediatric nephrology by identifying novel disease-associated genetic variation and translating these discoveries into clinical applications. This article reviews the diverse forms of genetic architecture that have been found to be associated with kidney diseases and traits...
March 2016: Journal of Pediatric Genetics
Yuan Yang, Min Luo, Li Xiao, Xue-Jing Zhu, Chang Wang, Xiao Fu, Shu-Guang Yuan, Fang Xiao, Hong Liu, Zheng Dong, Fu-You Liu, Lin Sun
In the clinic, the pathological types of chronic kidney diseases (CKD) are considered references for choosing treatment protocols. From a statistical viewpoint, a non-invasive method to predict pathological types of CKD is a focus of our work. In the current study, following a frequency analysis of the clinical indices of 588 CKD patients in the department of nephrology, a third-grade class-A hospital, a novel theory is proposed: "bi-directional cumulative probability dichotomy". Further, two models for the prediction and differential diagnosis of CKD pathological type are established...
2016: Scientific Reports
R X Ma, Z L Li, T Wang, G H Wu, Y L Wu
OBJECTIVE: To analyze the clinical features of multiple myeloma (MM) with renal insufficiency as the initial manifestation, and to improve the level of clinical diagnosis of MM, and reducing misdiagnosis of this disease. METHODS: To retrospectively analyze the clinical data of 140 patients with MM, who were admitted in our Department of Nephrology and Hematology. They were diagnosed as MM by bone marrow aspiration biopsy. The patients were divided into renal insufficiency group and normal renal function group, based on the criterion of serum creatinine >177 μmol/L...
July 2016: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
Claudio Pozzi, Thomas Rauen, Jürgen Floege
The Kidney Disease: Improving Global Outcomes (KDIGO) guidelines suggest a 6-month course of corticosteroids (CS) for IgA nephropathy (IgAN) patients with persistent proteinuria ≥1 g/day despite 3-6 months of renin-angiotensin system (RAS) blockers and glomerular filtration rate (GFR) >50 mL/min/1.73 m(2) In December 2015, Rauen et al. (N Engl J Med 2015; 373: 2225-2236) published an article entitled 'Intensive supportive care plus immunosuppression in IgA nephropathy' (STOP-IgAN), which presented results from 379 IgAN patients from 32 nephrology centres in Germany...
August 11, 2016: Nephrology, Dialysis, Transplantation
Matthias Wuttke, Anna Köttgen
Over the past decade, genome-wide association studies (GWAS) have considerably improved our understanding of the genetic basis of kidney function and disease. Population-based studies, used to investigate traits that define chronic kidney disease (CKD), have identified >50 genomic regions in which common genetic variants associate with estimated glomerular filtration rate or urinary albumin-to-creatinine ratio. Case-control studies, used to study specific CKD aetiologies, have yielded risk loci for specific kidney diseases such as IgA nephropathy and membranous nephropathy...
September 2016: Nature Reviews. Nephrology
Kibriya Fidan, Ipek Isik Gonul, Bahar Büyükkaragöz, Emel Isiyel, Turgay Arinsoy, Oguz Soylemezoglu
Renal biopsy is the gold standard method for determining the diagnosis, treatment, and prognosis in children with renal disease. This study aims to evaluate the histopathological features of pediatric renal biopsies obtained from the national nephrology registry in the last two decades. Data recorded in the Turkish Society of Nephrology Registry System (TSNRS) in 1991 as well as in between 2001 and 2010 were analyzed. A total of 3892 biopsies were recorded; with the least number in 1991 (total 103 biopsies from 17 centers) and the highest number in 2008 (total 654 biopsies from 23 centers)...
September 2016: Renal Failure
Beth Vogt
Although kidney disease is much less common in children than in adults, clinicians must remain alert for the renal conditions that occur in this population because prompt diagnosis and management are essential. Acute postinfectious glomerulonephritis occurs as an uncommon sequela of streptococcal and other infections. Management is focused on providing supportive measures, including management of fluid-electrolyte imbalance and hypertension, until the patient recovers. Immunoglobulin (Ig) A nephropathy is a primary glomerulonephritis related to abnormal IgA glycosylation...
May 2016: FP Essentials
Qing-Ying Fu, Lu Ma, Chang-Chun Li, Fa-Gui He, Zhi-Jun He, Wen-Sheng Zhang, Zhi-Hao Zhang
BACKGROUND/AIM: It has been shown that hypertension (HT) and prehypertension (Pre-HT) are associated with increased cardiovascular risk. However, the significance of secondary HT/Pre-HT in children with IgA nephropathy (IgAN) is uncertain. This study aimed to examine the clinical and histopathological features of pediatric patients with HT/Pre-HT. METHODS: Data on children with IgAN from a single Chinese nephrology center were retrospectively reviewed. Morphological changes were evaluated using the Oxford classification, parameters including crescents, glomerular activity index, glomerular chronicity index (GCI), arterial lesions and Lee's grading...
2016: Nephron
Soumita Bagchi, Geetika Singh, Rajni Yadav, Mani Kalaivani, Sandeep Mahajan, Dipankar Bhowmik, Amit Dinda, Sanjay Kumar Agarwal
BACKGROUND: IgA nephropathy (IgAN) is known to have an aggressive course in Asians. There is a paucity of data regarding the Oxford classification pattern of Indian patients with IgAN. This study aims to characterize the clinical and histopathologic profile of these patients. METHODS: All patients diagnosed to have primary IgAN by kidney biopsy in the nephrology department from July 2009 to July 2014 were included in this study. All kidney biopsies were reviewed and the MEST score was assigned as per the Oxford classification...
2016: Renal Failure
Y L Cao, M Qiao, Z H Xu, G M Zou, L L Ma, W G Li, B H Xu
OBJECTIVE: To explore the clinical characteristics of IgA nephropathy (IgAN) with severe chronic periodontitis and aggressive periodontitis. METHODS: A total of 436 hospitalized patients who underwent renal needle biopsy in the department of nephrology of China-Japan Friendship Hospital from November 2013 to December 2014 were recruited in the study and blindly had periodontal examination. The patients were divided into IgAN group and non-IgAN group according to the renal pathology...
January 5, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Motoshi Hattori, Masayuki Iwano, Mayumi Sako, Masataka Honda, Hirokazu Okada, Yuko Akioka, Akira Ashida, Yukihiko Kawasaki, Hideyasu Kiyomoto, Yoshio Terada, Daishi Hirano, Mikiya Fujieda, Shouichi Fujimoto, Takao Masaki, Shoichi Maruyama, Seiich Mastuo
BACKGROUND: Transition of adolescent and young adult (AYA) patients with childhood-onset chronic kidney diseases (C-CKD) from pediatric to adult renal services has received increasing attention. However, information on transition of Japanese patients with C-CKD is limited. METHODS: The Transition Medicine Working Group, in collaboration with the Japanese Society for Nephrology, the Japanese Society for Pediatric Nephrology and the Japanese Society of Pediatric Urology, conducted a retrospective cross-sectional study in 2014 on issues concerning the transition of Japanese patients with C-CKD...
January 19, 2016: Clinical and Experimental Nephrology
Soumita Bagchi, Parmod Mittal, Geetika Singh, Sanjay Kumar Agarwal, Lavleen Singh, Dipankar Bhowmik, Sandeep Mahajan, Amit Dinda
BACKGROUND: An aging population is an important demographic issue in India. The knowledge base about kidney diseases among the elderly Indians is inadequate. We aim to delineate the clinical profile and spectrum of biopsy-proven kidney disease in elderly patients. METHODS: Records of all elderly patients (≥60 years) who had undergone kidney biopsy in the nephrology department from January 2010 to December 2014 were reviewed. Their clinical details and laboratory investigations at the time of biopsy were noted...
April 2016: International Urology and Nephrology
Luciana Gravellone, Carmelo Battaglia, Fabiana Caligara, Ippolita D'Amato, Eligio Gandini, Angelo Lucatello, Maria Antonietta Rizzo, Regina Torpia, Gioconda Brigante, Alessandro Castiglioni
Strongyloides stercoralis is a nematode causing strongyloidiasis, more frequent in immigrants and in travelers coming from tropical and subtropical areas. Infection is usually asymptomatic, frequently associated with eosinophilia. Immunocompromised patients are at high risk of developing hyperinfection syndrome (HI) or dissemination (SD), life threatening complications. Diagnosis of strongyloidiasis is firstly based on larvae isolation in stool samples; specific therapy involves the use of ivermectin as first choice and albendazole as second choice...
March 2015: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
Shoko Matsushita, Kenji Ishikura, Shojiro Okamoto, Yusuke Okuda, Yoshinobu Nagaoka, Ryoko Harada, Riku Hamada, Tomoyuki Sakai, Yuko Hamasaki, Hiroshi Hataya, Takashi Ando, Kentaro Ogata, Masataka Honda
BACKGROUND: The long-term outcome of pediatric IgA nephropathy (IgAN) is unclear. Objective IgAN remission criteria were proposed by the Japanese Society of Nephrology in 2013. METHODS: Children with newly developed IgAN followed for >5 years were analyzed. They were divided into two groups based on histological findings at initial kidney biopsy: the focal mesangial proliferation group (Focal group) and diffuse mesangial proliferation group (Diffuse group). The primary outcome was the remission rate according to the newly proposed IgAN remission criteria...
December 2015: Clinical and Experimental Nephrology
Yoshikuni Nagayama, Hiroki Nishiwaki, Takeshi Hasegawa, Daisuke Komukai, Eri Kawashima, Mamiko Takayasu, Hironori Tayama, Yoshihiko Inoue, Kiyoko Inui, Ashio Yoshimura
BACKGROUND: In 2011, the Japanese Society of Nephrology (JSN) published new clinical guidelines for IgA nephropathy (IgAN) with a new risk stratification based on clinical and histological severity. For classification, patients are divided into four groups (low, medium, high, and very high risk). However, differences in responsiveness to each treatment among different groups remain unclear. We evaluate the responsiveness of tonsillectomy plus steroid pulse (TSP) therapy using the new risk stratification...
August 2015: Clinical and Experimental Nephrology
Savas Ozturk, Abdullah Sumnu, Nurhan Seyahi, Mustafa Gullulu, Murat Sipahioglu, Serra Artan, Zerrin Bicik, Sim Kutlay, Mustafa Keles, Deren Oygar, Ali Riza Odabas, Mansur Kayatas, Belda Dursun, Hayriye Sayarlioglu, Sinan Trablus, Dilek Guven Taymez, Ali Abbas Ozdemir, Gulizar Manga Sahin, Bulent Altun, Alper Azak, Lutfullah Altintepe, Gultekin Suleymanlar, Mehmet Koc, Yilmaz Selcuk, Rumeyza Kazancioglu, Reha Erkoc, Meltem Gursu, Mehmet Kucuk, Selma Alagoz Akcaoglu, Abdulmecid Yıldız, Aydin Unal, Ozger Akarsu, Kenan Ates, Erdem Cankaya, Aydin Turkmen
BACKGROUND: The aim of our study was to delineate the demographic and clinical properties of primary glomerular diseases of adult population in our country in the light of global knowledge. METHODS: All over the country, a total of 25 centers entered data between May 2009 and July 2012 to the database created by 'Glomerulonephritis Study Group' of Turkish Society of Nephrology. Demographic and clinical characteristics, specific diagnoses of glomerular diseases and biopsy findings recorded to the database were analyzed...
December 2014: International Urology and Nephrology
B Faria, C Henriques, A C Matos, M R Daha, M Pestana, M Seelen
A number of molecules have been shown recently to be involved in the pathogenesis and progression of immunoglobulin (Ig)A nephropathy (IgAN). Among these, we have selected C4d (complement lectin pathway involvement), CD3 (T cell marker, traducing interstitial inflammation), transglutaminase 2 (TGase-2, involved in tissue fibrosis development) and p-extracelluar-regulated kinase (ERK)1/2 (protein kinase intracellular signaling molecule) to perform a panel of immunohistological biomarkers and assess its predictive value for disease progression...
February 2015: Clinical and Experimental Immunology
Shuwei Duan, Shuwen Liu, Xuefeng Sun, Ying Zheng, Linchang Liu, Feixiang Yao, Jie Wu
BACKGROUND: The high blood homocysteine (Hcy) levels found in patients with hyperhomocysteinemia (HHcy) have been implicated in an increased risk of cardiovascular disease morbidity and mortality in end-stage renal disease (ESRD). This study investigated the association of HHcy with progression of IgA nephropathy. METHODS: We analyzed 108 participants newly diagnosed with IgA nephropathy between August 2005 and August 2007 in the Department of Nephrology, Chinese People's Liberation Army General Hospital...
2014: Chinese Medical Journal
A Hočevar, Z Rotar, J Ostrovršnik, V Jurčić, A Vizjak, M Dolenc Voljč, J Lindič, M Tomšič
BACKGROUND: IgA vasculitis (IgAV) is assumed to be uncommon in adults. OBJECTIVES: To determine the incidence rate of histologically proven IgAV in the adult Slovenian population. METHODS: A retrospective chart review of adult patients diagnosed with IgAV was performed at the departments of rheumatology, nephrology, infectious diseases and dermatovenereology at an integrated secondary/tertiary university teaching hospital. In order to avoid missing miscoded cases, the Institute of Pathology, University of Ljubljana, Slovenia, provided a list of all patients with an IgAV-compatible histological pattern on biopsy...
September 2014: British Journal of Dermatology
Rosanna Coppo
Proteasome (PS) is a sophisticated protein degradation machinery comprising a 20S proteolytic core particle provided with caspase-like, trypsin-like and chymotrypsin-like activities on ubiquitinilated proteins. The products of this selective, complex, controlled and strictly coordinated system play a crucial role in cell cycle progression and apoptosis; activation of transcription factors, cytokines and chemokines; degradation and generation of MHC class I-presented peptides. PS has recently emerged as a promising drug target in cancer therapy, and bortezomib has been approved for refractory multiple myeloma...
February 2014: Nephrology, Dialysis, Transplantation
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"