keyword
https://read.qxmd.com/read/38456638/acute-compartment-syndrome-and-rhabdomyolysis-caused-by-a-single-electrical-muscle-stimulation-in-a-46-year-old-female-professional-athlete-with-fibromyalgia-chronic-fatigue-syndrome-and-myofascial-disorder-a-case-report
#21
JOURNAL ARTICLE
Karen M von Deneen, Dereje Gobena Alemayehu, Ajit Khosla
Electrical muscle stimulation (EMS) training has been recognized as an effective modality for improving body composition, enhancing body strength, and facilitating injury recovery. However, individuals who are new to EMS training and those with certain chronic diseases should exercise caution due to the increased risk of rhabdomyolysis. This case report describes the occurrence of rhabdomyolysis and gluteal compartment syndrome following a single session of EMS training in a 46-year-old Caucasian female professional athlete...
March 5, 2024: Clinical Journal of Sport Medicine
https://read.qxmd.com/read/38454115/a-mathematical-model-for-the-transmission-of-co-infection-with-covid-19-and-kidney-disease
#22
JOURNAL ARTICLE
Md Abdul Hye, Md Haider Ali Biswas, Mohammed Forhad Uddin, Md M Rahman
The world suffers from the acute respiratory syndrome COVID-19 pandemic, which will be scary if other co-existing illnesses exacerbate it. The co-occurrence of the COVID-19 virus with kidney disease has not been available in the literature. So, further research needs to be conducted to reveal the transmission dynamics of COVID-19 and kidney disease. This study aims to create mathematical models to understand how COVID-19 interacts with kidney diseases in specific populations. Therefore, the initial step was to formulate a deterministic Susceptible-Infected-Recovered (SIR) mathematical model to depict the co-infection dynamics of COVID-19 and kidney disease...
March 7, 2024: Scientific Reports
https://read.qxmd.com/read/38453214/hyperactivation-and-altered-selection-of-b-cells-in-patients-with-paediatric-sjogren-s-syndrome
#23
JOURNAL ARTICLE
Alessandra Boni, Rebecca Nicolai, Ivan Caiello, Francesca Marinaro, Luciapia Farina, Denise Pires Marafon, Rita Carsetti, Fabrizio De Benedetti, Claudia Bracaglia, Emiliano Marasco
OBJECTIVES: Paediatric Sjögren's syndrome (pSS) is a rare chronic autoimmune disorder, characterised by inflammation of exocrine glands. B cell hyperactivation plays a central role in adult-onset Sjogren. This study was designed to analyse B cell and T cell phenotype, levels of BAFF, and selection of autoreactive B cells in patients with pSS. METHODS: A total of 17 patients diagnosed with pSS and 13 healthy donors (controls) comparable for age were enrolled in the study...
March 6, 2024: RMD Open
https://read.qxmd.com/read/38449983/acute-compartment-syndrome-of-the-thigh-after-contusion-in-a-football-player
#24
Guilherme Correia, Pedro Mendes Santos, João Pedro Campos, Nuno Camelo Barbosa, Luís Carvalho
Acute compartment syndrome of the thigh is an exceptionally uncommon condition that can have severe consequences if not promptly and effectively treated. A 19-year-old man presented to our emergency department with severe and progressive pain in his left thigh after sustaining a direct trauma during a football game 24 hours prior. Compartment pressure was assessed, confirming the diagnosis of compartment syndrome arising from a sizable intramuscular hematoma without detection of any other contributing factors...
February 2024: Curēus
https://read.qxmd.com/read/38448978/zebrafish-as-a-model-to-investigate-a-biallelic-gain-of-function-variant-in-msgn1-associated-with-a-novel-skeletal-dysplasia-syndrome
#25
JOURNAL ARTICLE
Asuman Koparir, Caroline Lekszas, Kemal Keseroglu, Thalia Rose, Lena Rappl, Aboulfazl Rad, Reza Maroofian, Nakul Narendran, Atefeh Hasanzadeh, Ehsan Ghayoor Karimiani, Felix Boschann, Uwe Kornak, Eva Klopocki, Ertuğrul M Özbudak, Barbara Vona, Thomas Haaf, Daniel Liedtke
BACKGROUND/OBJECTIVES: Rare genetic disorders causing specific congenital developmental abnormalities often manifest in single families. Investigation of disease-causing molecular features are most times lacking, although these investigations may open novel therapeutic options for patients. In this study, we aimed to identify the genetic cause in an Iranian patient with severe skeletal dysplasia and to model its molecular function in zebrafish embryos. RESULTS: The proband displays short stature and multiple skeletal abnormalities, including mesomelic dysplasia of the arms with complete humero-radio-ulna synostosis, arched clavicles, pelvic dysplasia, short and thin fibulae, proportionally short vertebrae, hyperlordosis and mild kyphosis...
March 6, 2024: Human Genomics
https://read.qxmd.com/read/38448942/knowledge-and-associated-factors-with-respect-to-prevention-of-post-traumatic-compartment-syndrome-among-surgical-unit-nurses-a-multi-center-cross-sectional-study
#26
JOURNAL ARTICLE
Astewil Moges Bazezew, Yalemwork Getahun, Tiruye Azene Demlie, Desalegn Getachew Ayele, Tsehayu Melak Siyoum, Gezahagn Demsu Gedefaw, Kasaye Ahmed Zeleke, Esayas Alemshet Tekletsadik, Sintayehu Simie Tsega, Melkamu Tilahun Dessie, Ashenafi Fekad Getahun, Ashenafi Worku Woretaw
BACKGROUND: Delayed recognition of compartment syndrome can result in devastating consequences such as the need for amputation or even death. Nurses are at the frontline of patient care and they must have a high index of suspicion for compartment syndrome. Even though nurses' knowledge about the prevention of compartment syndrome is important, there are no studies in Ethiopia. Therefore this study aims to assess the knowledge and associated factors of nurses towards the prevention of post-traumatic compartment syndrome...
March 6, 2024: BMC Nursing
https://read.qxmd.com/read/38445548/population-pharmacokinetics-enzyme-occupancy-and-pharmacodynamic-modeling-of-soticlestat-in-patients-with-developmental-and-epileptic-encephalopathies
#27
JOURNAL ARTICLE
Wei Yin, Axel Facius, Mahnaz Asgharnejad, Gëzim Lahu, Majid Vakilynejad
Soticlestat (TAK-935) is a first-in-class, selective inhibitor of cholesterol 24-hydroxylase (CH24H) under phase III development for the treatment of the developmental and epileptic encephalopathies (DEEs), Dravet syndrome (DS), and Lennox-Gastaut syndrome (LGS). A previous model characterized the pharmacokinetics (PKs), CH24H enzyme occupancy (EO), and pharmacodynamics (PDs) of soticlestat in healthy volunteers. The present study extended this original model for patients with DEEs and investigated sources of variability...
March 2024: Clinical and Translational Science
https://read.qxmd.com/read/38445357/pharmacokinetic-study-of-multicomponent-in-hong-hua-xiao-yao-tablet
#28
JOURNAL ARTICLE
Xiaofeng Li, Leyi Huang, Junping Xiao, Xuemei Zhang
Hong-Hua-Xiao-Yao tablet (HHXYT) is attracting attention increasingly because of its use in treatment of mammary gland hyperplasia (MGH) and menopausal syndrome. However, its pharmacokinetics remains unclear. This study developed a sensitive and rapid method for simultaneous determination of 10 compounds of HHXYT in rat plasma by liquid chromatography-tandem mass spectrometry and to compare the pharmacokinetics of these compounds in MGH rats and sham operated rats. The linearity, accuracy, precision, stability and matrix effect were within acceptable ranges...
March 6, 2024: Biomedical Chromatography: BMC
https://read.qxmd.com/read/38445292/dynamic-changes-in-ai-based-analysis-of-endometrial-cellular-composition-analysis-of-pcos-and-rif-endometrium
#29
JOURNAL ARTICLE
Seungbaek Lee, Riikka K Arffman, Elina K Komsi, Outi Lindgren, Janette Kemppainen, Keiu Kask, Merli Saare, Andres Salumets, Terhi T Piltonen
BACKGROUND: The human endometrium undergoes a monthly cycle of tissue growth and degeneration. During the mid-secretory phase, the endometrium establishes an optimal niche for embryo implantation by regulating cellular composition (e.g., epithelial and stromal cells) and differentiation. Impaired endometrial development observed in conditions such as polycystic ovary syndrome (PCOS) and recurrent implantation failure (RIF) contributes to infertility. Surprisingly, despite the importance of the endometrial lining properly developing prior to pregnancy, precise measures of endometrial cellular composition in these two infertility-associated conditions are entirely lacking...
December 2024: Journal of Pathology Informatics
https://read.qxmd.com/read/38444773/risk-factors-for-tibial-infections-following-osteosynthesis-a-systematic-review-and-meta-analysis
#30
REVIEW
Diana Niebuhr, Thomas Mattson, Niels Martin Jensen, Bjarke Viberg, Signe Steenstrup Jensen
AIM: This study aimed to quantitatively summarise risk factors associated with surgical site infection (SSI) following surgically managed tibial fractures. METHOD: We searched the Embase/Medline, Cochrane Library, and Scopus databases for relevant studies in October 2023. We included original studies investigating risk factors for SSI following surgically managed traumatic tibial fractures that included ≥10 adult patients with SSIs. Meta-analysis was performed when >5 studies investigated the same risk factor...
March 2024: Journal of Clinical Orthopaedics and Trauma
https://read.qxmd.com/read/38444415/pulmonary-inflammation-decreases-with-ultra-protective-ventilation-in-experimental-ards-under-vv-ecmo-a-positron-emission-tomography-study
#31
JOURNAL ARTICLE
Guillaume Deniel, François Dhelft, Sophie Lancelot, Maciej Orkisz, Emmanuel Roux, William Mouton, Nazim Benzerdjeb, Jean-Christophe Richard, Laurent Bitker
BACKGROUND: Experimentally, ultra-protective ventilation (UPV, tidal volumes [VT ] < 4 mL.kg-1 ) strategies in conjunction with veno-venous extracorporeal membrane oxygenation (VV-ECMO) are associated with lesser ventilator-induced lung injuries (VILI) during acute respiratory distress syndrome (ARDS). However, whether these strategies reduce lung inflammation more effectively than protective ventilation (PV) remains unclear. We aimed to demonstrate that a UPV strategy decreases acute lung inflammation in comparison with PV in an experimental swine model of ARDS...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38444118/phase-1-randomized-pharmacokinetic-and-safety-study-of-a-90-day-tenofovir-vaginal-ring-in-the-united-states
#32
RANDOMIZED CONTROLLED TRIAL
Albert Y Liu, Holly Gundacker, Barbra Richardson, Beatrice A Chen, Craig Hoesley, Ariane van der Straten, Amanda Brown, May Beamer, Jennifer Robinson, Cindy E Jacobson, Rachel Scheckter, Katherine Bunge, Jill Schwartz, Andrea Thurman, Jeanna M Piper, Mark A Marzinke
INTRODUCTION: Tenofovir-based oral pre-exposure prophylaxis is currently approved for HIV prevention; however, adherence in women has been low. A vaginal gel containing tenofovir (TFV) demonstrated partial protection to HIV but protection was not confirmed in additional studies. Vaginal rings offer user-controlled long-acting HIV prevention that could overcome adherence and protection challenges. TFV may also help prevent herpes simplex virus type 2 acquisition when delivered intravaginally...
March 2024: Journal of the International AIDS Society
https://read.qxmd.com/read/38439871/gluteal-compartment-syndrome-secondary-to-prolonged-immobilization-following-carbon-monoxide-poisoning-associated-with-leukoencephalopathy-a-case-report
#33
Mohammad Shujauddin, Ashraf T Hantouly, Isam Moghamis, Osama Alzobi, Fuad Vayalil Mazhar, Mohamed Maged Mekhaimar
INTRODUCTION: Gluteal compartment syndrome (GCS) is a rare diagnosis that results mostly from a non-traumatic etiology. We describe a case of a gluteal compartment syndrome, complicated with sciatic nerve palsy. CASE PRESENTATION: This paper reported a case of gluteal compartment syndrome caused by prolonged immobilization due to carbon monoxide poisoning. The case was complicated with sciatic nerve palsy and a sequala of leukoencephalopathy. DISCUSSION AND CONCLUSION: This case report highlighted the importance of having a high suspicion for gluteal compartment syndrome in patients with history of lying down with prolonged immobilization...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38435905/-fanged-to-peril-interesting-snake-bite-case-series
#34
Vivek Mahadevaiah, Kalpana Ravikumar, Harismitha Manjunath
Snakebite is an acute life-threatening medical emergency and is included among the neglected tropical diseases in India. The incidence of snakebite mortality is particularly high in Southeast Asia and India has the highest number of cases of snakebites with a mortality of 35,000 to 50,000 cases per year according to the World Health Organization (WHO) direct estimation. There are three families of venomous snakes in Southeast Asia which mainly include Elapidae, Viperidae, and Colubridae. Snakebite victims show varied clinical presentations ranging from local signs to systemic signs of envenomation...
January 2024: Curēus
https://read.qxmd.com/read/38434332/viperidae-snake-envenomation-from-a-highly-complex-hospital-in-southwestern-colombia
#35
JOURNAL ARTICLE
Valeria Erazo-Martínez, Iván Posso-Osorio, Ingrid Ruiz-Ordoñez, Fernando Castro-Herrera, Santiago Castaño-Valencia, Tatiana Delgado-Mora, Carlos A Cañas
BACKGROUND: Snake envenomation is a medical condition with high morbidity and mortality in southwestern Colombia. OBJECTIVES: To describe the characteristics of the envenomation caused by Viperidae snakes view in a highly complex hospital in Southwestern Colombia. METHODS: A cross-sectional study was carried out. Patients treated for Viperidae snake envenomation from 2001 to 2020 in a Hospital Fundación Valle del Lili, Cali, Colombia, were studied...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38433801/a-computed-tomography-scan-near-miss-of-an-intraorbital-wooden-foreign-body
#36
JOURNAL ARTICLE
Armin Farahvash, Annie M Q Wang, Felipe Cardemil, Hall F Chew, Harmeet S Gill, Oleh M Antonyshyn
When intraorbital wooden foreign bodies are missed, the consequences can be devastating. While the gold standard diagnostic imaging is computed tomography (CT), it has low sensitivity. We present a 61-year-old man with a bamboo injury to his right eye. He underwent two CT scans that failed to raise the possibility of intraorbital foreign bodies. Upon additional review, a rectangular-shaped pocket of air was identified in the orbit which was most consistent with wooden foreign bodies based on the clinical history...
February 2024: Plastic Surgery
https://read.qxmd.com/read/38431446/incidence-implications-and-predictors-of-abdominal-compartment-syndrome-in-acute-pancreatitis-a-nationwide-analysis
#37
JOURNAL ARTICLE
Ali Jaan, Zouina Sarfraz, Umer Farooq, Sheza Malik, Asad Ur Rahman, Patrick Okolo
BACKGROUND: Acute pancreatitis (AP) often presents with varying severity, with a small fraction evolving into severe AP, and is associated with high mortality. Complications such as intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) are intricately associated with AP. OBJECTIVE: To assess the clinical implications and predictors of ACS in AP patients. METHODS: We conducted a retrospective study using the National Inpatient Sample (NIS) database on adult AP patients, further stratified by the presence of concurrent ACS...
February 18, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38427052/predictive-factors-for-infection-after-osteosynthesis-of-tibial-plateau-fractures-a-retrospective-study-of-314-patients
#38
JOURNAL ARTICLE
Rodrigo Olivieri, Marco Koch, José Laso, Nicolás Franulic, Hugo Zanetta
INTRODUCTION: The reported incidence of infection related with tibial plateau fractures (IRTPF) ranges from 2 to 23%. This complication can result in catastrophic consequences such as deformity, post-traumatic osteoarthritis, chronic pain, loss of function, and substantial economic burdens on healthcare systems due to extended hospital stays and the resources required for treatment. Consequently, it is imperative to emphasize the identification of infection risk factors. METHODS: A retrospective case-control study was designed, encompassing patients who underwent surgery for tibial plateau fractures between 2015 and 2020...
March 1, 2024: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://read.qxmd.com/read/38422191/type-iii-popliteal-artery-entrapment-syndrome-with-concurrent-chronic-exertional-compartment-syndrome-a-case-report
#39
JOURNAL ARTICLE
Chenée Armando, Paul Sherbondy, Eugene Simoni, Sandra Cole
CASE: The patient, a 21-year-old female Division I track and field athlete, presents with bilateral calf pain, tightness, numbness, and swelling during activity. Initially diagnosed with chronic exertional compartment syndrome (CECS), she underwent bilateral four-compartment fasciotomies. After 4 months, she experienced persistence of some of her prefasciotomy symptoms and was referred to vascular surgery. A fibrous band was compressing the popliteal artery, making the diagnosis of popliteal artery entrapment syndrome (PAES)...
January 1, 2024: JBJS Case Connector
https://read.qxmd.com/read/38420237/bilateral-upper-extremity-acute-exertional-compartment-syndrome-a-case-report
#40
Kanwar Partap S Parhar, David Frolov, Vadim Dolgov, Michael Quan, Miguel A Schmitz
INTRODUCTION: Acute exertional compartment syndrome (AECS) is a condition with the potential for devastating outcomes if not promptly treated. Physicians must maintain a high index of suspicion when evaluating patients presenting with pain, swelling, decreased range of motion, and numbness within a muscle compartment. However, AECS is frequently misdiagnosed due to a multitude of factors, leading to a delay in treatment. In this case report, we would like to shed light on a rare case of bilateral upper-extremity AECS and suggest the treatment paradigm we believe will help prevent negative outcomes...
February 2024: Journal of Orthopaedic Case Reports
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