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Mammary stem cell

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https://www.readbyqxmd.com/read/29644495/does-the-mouse-mammary-gland-arise-from-unipotent-or-multipotent-mammary-stem-progenitor-cells
#1
REVIEW
Gilbert H Smith, Daniel Medina
The presence of long-lived lineage restricted progenitor and multipotent progenitor cells in adult mouse mammary gland for cancer development is compelling. Mammary cancers are phenotypically diverse This might be explained by transformation of long-lived, lineage-limited progenitor subpopulations. Mammary multipotent epithelial stem cells and their environmental niches must be considered, since their niche(s), once empty might be occupied by lineage-limited progenitors that are proximal. The existence of premalignant mammary populationst that manifest characteristics of lineage limitation argues strongly for this proposition...
April 11, 2018: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/29642945/rna-sequencing-of-murine-mammary-epithelial-stem-like-cells-hc11-undergoing-lactogenic-differentiation-and-its-comparison-with-embryonic-stem-cells
#2
Trinadha Rao Sornapudi, Rakhee Nayak, Prashanth Kumar Guthikonda, Srinivas Kethavath, Sailu Yellaboina, Sreenivasulu Kurukuti
OBJECTIVES: Understanding of transcriptional networks specifying HC11 murine mammary epithelial stem cell-like cells (MEC) in comparison with embryonic stem cells (ESCs) and their rewiring, under the influence of glucocorticoids (GC) and prolactin (PRL) hormones, is critical for elucidating the mechanism of lactogenesis. In this data note, we provide RNA sequencing data from murine MECs and ESCs, MECs treated with steroid hormone alone and in combination with PRL. This data could help in understanding temporal dynamics of mRNA transcription that impact the process of lactogenesis associated with mammary gland development...
April 11, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29627127/the-action-of-estrogens-and-progestogens-in-the-young-female-breast
#3
Irene Zolfaroli, Juan J Tarín, Antonio Cano
Evidence from different sources sustains a pro-oncogenic role of hormones, estrogens and progestogens, on the breast. The issue is of interest for young women, who are exposed to the hormonal changes imposed by the ovarian cycle and, often, take hormones with contraceptive purposes. Experimental and clinical studies show that both estrogens and progesterone are involved in mammary development during puberty and lactation, the changes being observed across mammalian species, including humans. Estrogen receptors, and more particularly the alpha isoform, participate in molecular processes of stem cells differentiation and epithelial proliferation through paracrine actions implicating growth factors...
March 28, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29624022/simvastatin-modulates-%C3%AE-catenin-mdr1-expression-on-spheres-derived-from-cf41-mg-canine-mammary-carcinoma-cells
#4
P Cruz, F Reyes, C G Torres
The presence of cancer stem-like cells (CSC) within canine mammary tumors, may explain partly local recurrence and spreading, since their ability to resist conventional antitumor treatments as chemo and radiotherapy. It has been recently described that simvastatin - a drug that inhibits synthesis of cholesterol - attenuates the proliferation of canine mammary CSC derived from CF41.Mg canine mammary carcinoma cells, promoting their chemosensitizing and apoptosis. The canonical Wnt/β-catenin pathway is usually activated at CSC and up-regulates multidrug resistance protein 1 (MDR1), triggering chemoresistance...
March 2018: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29620414/cd24-and-cd49f-expressions-of-e14-5-mouse-mammary-anlagen-cells-defines-putative-distribution-of-earlier-embryonic-mammary-stem-cell-activities
#5
Jiazhe Song, Fang Rong Ding, Song Li, Wenzhe Li, Ning Li, Kai Xue
Stem cell biology offers promise for understanding the origins of mammary gland. However, the distribution of mammary stem cell (MaSC) activities at earlier embryonic stage has not been fully identified. As the markers for sorting adult MaSC, CD24, CD29 and CD49f have been applied to analyze fetal MaSCs. Here we explored mammary anlagen MaSCs by investigating CD24/CD49f expressions. According to the comparative analysis between adult mammary gland and fetal mammary anlagen, we found that fetal mouse mammary anlagen might possess high percentage of potential MaSCs...
April 5, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29617367/gene-set-analysis-of-post-lactational-mammary-gland-involution-gene-signatures-in-inflammatory-and-triple-negative-breast-cancer
#6
Arvind Bambhroliya, Renae D Van Wyhe, Swaminathan Kumar, Bisrat G Debeb, Jay P Reddy, Steve Van Laere, Randa El-Zein, Arvind Rao, Wendy A Woodward
BACKGROUND: Epidemiological studies have found that triple-negative breast cancer (TNBC) and TN inflammatory breast cancer (IBC) are associated with lower frequency and duration of breast-feeding compared to non-TNBC and non-TN IBC, respectively. Limited breast-feeding could reflect abrupt or premature involution and contribute to a "primed" stroma that is permissive to the migration of cancer cells typical of IBC. We hypothesized that gene expression related to abrupt mammary gland involution after forced weaning may be enriched in the tissues of IBC patients and, if so, provide a potential correlation between limited breast-feeding and the development of aggressive breast cancer...
2018: PloS One
https://www.readbyqxmd.com/read/29606612/heterogeneity-of-human-breast-stem-and-progenitor-cells-as-revealed-by-transcriptional-profiling
#7
Justin A Colacino, Ebrahim Azizi, Michael D Brooks, Ramdane Harouaka, Shamileh Fouladdel, Sean P McDermott, Michael Lee, David Hill, Julie Madden, Julie Boerner, Michele L Cote, Maureen A Sartor, Laura S Rozek, Max S Wicha
During development, the mammary gland undergoes extensive remodeling driven by stem cells. Breast cancers are also hierarchically organized and driven by cancer stem cells characterized by CD44+ CD24low/- or aldehyde dehydrogenase (ALDH) expression. These markers identify mesenchymal and epithelial populations both capable of tumor initiation. Less is known about these populations in non-cancerous mammary glands. From RNA sequencing, ALDH+ and ALDH- CD44+ CD24- human mammary cells have epithelial-like and mesenchymal-like characteristics, respectively, with some co-expressing ALDH+ and CD44+ CD24- by flow cytometry...
March 20, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29600163/the-role-of-steroid-hormones-in-breast-and-effects-on-cancer-stem-cells
#8
REVIEW
Denis G Alferez, Bruno M Simões, Sacha J Howell, Robert B Clarke
Purpose of Review: This review will discuss how the steroid hormones, estrogen and progesterone, as well as treatments that target steroid receptors, can regulate cancer stem cell (CSC) activity. The CSC theory proposes a hierarchical organization in tumors where at its apex lies a subpopulation of cancer cells endowed with self-renewal and differentiation capacity. Recent Findings: In breast cancer (BC), CSCs have been suggested to play a key role in tumor maintenance, disease progression, and the formation of metastases...
2018: Current Stem Cell Reports
https://www.readbyqxmd.com/read/29596308/ep4-as-a-therapeutic-target-for-aggressive-human-breast-cancer
#9
REVIEW
Mousumi Majumder, Pinki Nandi, Ahmed Omar, Kingsley Chukwunonso Ugwuagbo, Peeyush K Lala
G-protein-coupled receptors (GPCRs, also called seven-transmembrane or heptahelical receptors) are a superfamily of cell surface receptor proteins that bind to many extracellular ligands and transmit signals to an intracellular guanine nucleotide-binding protein (G-protein). When a ligand binds, the receptor activates the attached G-protein by causing the exchange of Guanosine-5'-triphosphate (GTP) for guanosine diphosphate (GDP). They play a major role in many physiological functions, as well as in the pathology of many diseases, including cancer progression and metastasis...
March 29, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29594259/17-%C3%AE-estradiol-and-ici182-780-differentially-regulate-stat5-isoforms-in-female-mammary-epithelium-with-distinct-outcomes
#10
Fatou Jallow, Jennifer L Brockman, Kyle T Helzer, Debra E Rugowski, Vincent Goffin, Elaine T Alarid, Linda A Schuler
Prolactin (PRL) and estrogen cooperate in lobuloalveolar development of the mammary gland and jointly regulate gene expression in breast cancer cells in vitro . Canonical PRL signaling activates STAT5A/B, homologous proteins that have different target genes and functions. Although STAT5A/B are important for physiological mammary function and tumor pathophysiology, little is known about regulation of their expression, particularly of STAT5B, and the consequences for hormone action. In this study, we examined the effect of two estrogenic ligands, 17 β -estradiol (E2) and the clinical antiestrogen, ICI182,780 (ICI, fulvestrant) on expression of STAT5 isoforms and resulting crosstalk with PRL in normal and tumor murine mammary epithelial cell lines...
March 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29581836/runx1-and-runx3-protect-against-yap-mediated-emt-stem-ness-and-shorter-survival-outcomes-in-breast-cancer
#11
Madhura Kulkarni, Tuan Zea Tan, Nurfarhanah Bte Syed Sulaiman, John M Lamar, Prashali Bansal, Jianzhou Cui, Yiting Qiao, Yoshiaki Ito
Hippo pathway target, YAP has emerged as an important player in solid tumor progression. Here, we identify RUNX1 and RUNX3 as novel negative regulators of oncogenic function of YAP in the context of breast cancer. RUNX proteins are one of the first transcription factors identified to interact with YAP. RUNX1 or RUNX3 expression abrogates YAP-mediated pro-tumorigenic properties of mammary epithelial cell lines in an interaction dependent manner. RUNX1 and RUNX3 inhibit YAP-mediated migration and stem-ness properties of mammary epithelial cell lines by co-regulating YAP-mediated gene expression...
March 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29569804/in-vitro-fusion-of-normal-and-neoplastic-breast-epithelial-cells-with-human-mesenchymal-stroma-stem-cells-msc-partially-involves-tnf-receptor-signaling
#12
Catharina Melzer, Juliane von der Ohe, Ralf Hass
BACKGROUND: Formation of hybrid cells by "accidental cell fusion" of normal and neoplastic breast epithelial cells with local tissue-associated mesenchymal stroma/stem-like cells (MSC) in an inflammatory microenvironment can generate new cancer cell populations whereby molecular signaling mechanisms of this process remain unclear. METHODS: Fusions of lentiviral eGFP-labeled MSC with mcherry-labeled breast epithelial cells were quantified and effects of TNF-α and receptor downstream signaling were investigated...
March 23, 2018: Stem Cells
https://www.readbyqxmd.com/read/29567480/wnt3-and-gata4-regulate-axon-regeneration-in-adult-mouse-drg-neurons
#13
Run-Shan Duan, Pei-Pei Liu, Feng Xi, Wei-Hua Wang, Gang-Bin Tang, Saijilafu, Rui-Ying Wang, Chang-Mei Liu
Neurons in the adult central nervous system (CNS) have a poor intrinsic axon growth potential after injury, but the underlying mechanisms are largely unknown. Wingless-related mouse mammary tumor virus integration site (WNT) family members regulate neural stem cell proliferation, axon tract and forebrain development in the nervous system. Here we report that Wnt3 is an important modulator of axon regeneration. Downregulation or overexpression of Wnt3 in adult dorsal root ganglion (DRG) neurons enhances or inhibits their axon regeneration ability respectively in vitro and in vivo...
March 19, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29547583/therapeutic-and-preventive-effects-of-osteoclastogenesis-inhibitory-factor-on-osteolysis-proliferation-of-mammary-tumor-cell-and-induction-of-cancer-stem-cells-in-the-bone-microenvironment
#14
Mitsuru Futakuchi, Takao Nitanda, Saeko Ando, Harutoshi Matsumoto, Eri Yoshimoto, Katsumi Fukamachi, Masumi Suzui
BACKGROUND: We examined the effects of recombinant human osteoclastogenesis inhibitory factor (hOCIF) on osteolysis, proliferation of mammary tumor cells, and induction of cancer stem cells (CSCs) in the tumor-bone and tumor-subcutaneous microenvironments (TB- and TS-microE). METHODS: Mouse mammary tumor cells were transplanted onto the calvaria or into a subcutaneous lesion of female mice, creating a TB-microE and a TS-microE, and the mice were then treated with hOCIF...
March 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29540259/histone-tail-cleavage-as-a-novel-epigenetic-regulatory-mechanism-for-gene-expression
#15
Sun-Ju Yi, Kyunghwan Kim
Chromatin is an intelligent building block that can express either external or internal needs through structural changes. To date, three methods to change chromatin structure and regulate gene expression have been well-documented: histone modification, histone exchange, and ATP-dependent chromatin remodeling. Recently, a growing body of literature has suggested that histone tail cleavage is related to various cellular processes including stem cell differentiation, osteoclast differentiation, granulocyte differentiation, mammary gland differentiation, viral infection, aging, and yeast sporulation...
March 15, 2018: BMB Reports
https://www.readbyqxmd.com/read/29533546/telocytes-in-the-female-reproductive-system-an-overview-of-up-to-date-knowledge
#16
REVIEW
Przemysław Janas, Iwona Kucybała, Małgorzata Radoń-Pokracka, Hubert Huras
Telocytes are emerging cell population localized in the stroma of numerous organs, characterized by a distinctive morphology - small cell body with very long, slender prolongations, termed telopodes. Those cells can be found in the whole female reproductive system: in the vagina, uterus, oviducts and ovaries, mammary glands and also in the placenta. In our review, we aim at complete and transparent revision of the current knowledge of telocytes' localization and function, enriched by the analysis of the possible future direction of development of their clinical applications...
March 13, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29523789/insc-lgn-tetramers-promote-asymmetric-divisions-of-mammary-stem-cells
#17
Simone Culurgioni, Sara Mari, Paola Bonetti, Sara Gallini, Greta Bonetto, Martha Brennich, Adam Round, Francesco Nicassio, Marina Mapelli
Asymmetric cell divisions balance stem cell proliferation and differentiation to sustain tissue morphogenesis and homeostasis. During asymmetric divisions, fate determinants and niche contacts segregate unequally between daughters, but little is known on how this is achieved mechanistically. In Drosophila neuroblasts and murine mammary stem cells, the association of the spindle orientation protein LGN with the stem cell adaptor Inscuteable has been connected to asymmetry. Here we report the crystal structure of Drosophila LGN in complex with the asymmetric domain of Inscuteable, which reveals a tetrameric arrangement of intertwined molecules...
March 9, 2018: Nature Communications
https://www.readbyqxmd.com/read/29523784/myc-driven-epigenetic-reprogramming-favors-the-onset-of-tumorigenesis-by-inducing-a-stem-cell-like-state
#18
Vittoria Poli, Luca Fagnocchi, Alessandra Fasciani, Alessandro Cherubini, Stefania Mazzoleni, Sara Ferrillo, Annarita Miluzio, Gabriella Gaudioso, Valentina Vaira, Alice Turdo, Miriam Giaggianesi, Aurora Chinnici, Elisa Lipari, Silvio Bicciato, Silvano Bosari, Matilde Todaro, Alessio Zippo
Breast cancer consists of highly heterogeneous tumors, whose cell of origin and driver oncogenes are difficult to be uniquely defined. Here we report that MYC acts as tumor reprogramming factor in mammary epithelial cells by inducing an alternative epigenetic program, which triggers loss of cell identity and activation of oncogenic pathways. Overexpression of MYC induces transcriptional repression of lineage-specifying transcription factors, causing decommissioning of luminal-specific enhancers. MYC-driven dedifferentiation supports the onset of a stem cell-like state by inducing the activation of de novo enhancers, which drive the transcriptional activation of oncogenic pathways...
March 9, 2018: Nature Communications
https://www.readbyqxmd.com/read/29503088/bcl11b-drives-human-mammary-stem-cell-self-renewal-in-vitro-by-inhibiting-basal-differentiation
#19
Daniel H Miller, Dexter X Jin, Ethan S Sokol, Janel R Cabrera, Daphne A Superville, Rebecca A Gorelov, Charlotte Kuperwasser, Piyush B Gupta
The epithelial compartment of the mammary gland contains basal and luminal cell lineages, as well as stem and progenitor cells that reside upstream in the differentiation hierarchy. Stem and progenitor cell differentiation is regulated to maintain adult tissue and mediate expansion during pregnancy and lactation. The genetic factors that regulate the transition of cells between differentiation states remain incompletely understood. Here, we present a genome-scale method to discover genes driving cell-state specification...
March 13, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29494240/defining-adult-stem-cells-by-function-not-by-phenotype
#20
Hans Clevers, Fiona M Watt
Central to the classical hematopoietic stem cell (HSC) paradigm is the concept that the maintenance of blood cell numbers is exclusively executed by a discrete physical entity: the transplantable HSC. The HSC paradigm has served as a stereotypic template in stem cell biology, yet the search for rare, hardwired professional stem cells has remained futile in most other tissues. In a more open approach, the focus on the search for stem cells as a physical entity may need to be replaced by the search for stem cell function, operationally defined as the ability of an organ to replace lost cells...
March 1, 2018: Annual Review of Biochemistry
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