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Eclampsia pre eclampsia

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https://www.readbyqxmd.com/read/29786509/-targeted-screening-for-pre-eclampsia-in-the-first-trimester-of-pregnancy-at-toulouse-university-hospital
#1
A Genoux, P Guerby, M Morin, B Perret, C Vayssière, S M Hamdi
GOALS: Preeclampsia (PE) is a leading cause of maternal and neonatal morbidity and mortality. Early treatment by aspirin has been shown to significantly reduce PE risk before 37weeks supporting the implementation of first-trimester screening. SUBJECTS AND METHODS: A targeted screening was recently implemented at Toulouse University Hospital for women in their first pregnancy or those with personal or familial history of PE. It uses Fetal Medicine Foundation (FMF) algorithm that combines maternal characteristics, clinical, biophysical and biochemical (PAPP-A, Pregnancy Associated Plasma Protein-A, and PlGF, Placental Growth Factor) data...
May 18, 2018: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/29783717/associations-of-maternal-vitamin-d-deficiency-with-pregnancy-and-neonatal-complications-in-developing-countries-a-systematic-review
#2
REVIEW
Paige van der Pligt, Jane Willcox, Ewa A Szymlek-Gay, Emily Murray, Anthony Worsley, Robin M Daly
Pregnant women in Asia, the Middle East, Africa and Latin America are at risk of vitamin D deficiency (VDD) and prevalence throughout these regions are among the highest, globally. Maternal VDD has been associated with increased risk of a number of adverse maternal and neonatal health outcomes, yet research from developing countries is limited. We assessed the associations of maternal VDD during pregnancy with adverse health outcomes by synthesizing the literature from observational studies conducted in developing countries...
May 18, 2018: Nutrients
https://www.readbyqxmd.com/read/29782139/obstetric-outcomes-after-fresh-versus-frozen-thawed-embryo-transfers-a-systematic-review-and-meta-analysis
#3
Matheus Roque, Marcello Valle, Marcos Sampaio, Selmo Geber
OBJECTIVE: To evaluate if there are differences in the risks of obstetric outcomes in IVF/ICSI singleton pregnancies when compared fresh to frozen-thawed embryo transfers (FET). METHODS: This was a systematic review and meta-analysis evaluating the obstetric outcomes in singleton pregnancies after FET and fresh embryo transfer. The outcomes included in this study were pregnancy-induced hypertension (PIH), pre-eclampsia, placenta previa, and placenta accreta. RESULTS: The search yielded 654 papers, 6 of which met the inclusion criteria and reported on obstetric outcomes...
May 21, 2018: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/29782065/foley-catheter-vs-oral-misoprostol-to-induce-labour-among-hypertensive-women-in-india-a-cost-consequence-analysis-alongside-a-clinical-trial
#4
Simon Leigh, Paul Granby, Alan Haycox, Shuchita Mundle, Hillary Bracken, Vaishali Khedikar, Jayashree Mulik, Brian Faragher, Thomas Easterling, Mark A Turner, Zarko Alfirevic, Beverly Winikoff, Andrew D Weeks
OBJECTIVE: To determine the effectiveness and economic impact of two methods for induction of labour in hypertensive women, in low-resource settings. DESIGN: Cost-consequence analysis of a previously reported multi-centre, parallel, open-label randomized trial. SETTING & POPULATION: 602 women with a live fetus, aged>18 years requiring delivery for pre-eclampsia or hypertension, in two public hospitals in Nagpur, India. METHODS: We performed a formal economic evaluation alongside the INFORM clinical trial...
May 21, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29779493/molar-pregnancy-with-normal-viable-fetus-presenting-with-severe-pre-eclampsia-a-case-report
#5
Freddie Anak Atuk, Juliana Binti Mohamad Basuni
BACKGROUND: While gestational trophoblastic disease is not rare, hydatidiform mole with a coexistent live fetus is a very rare condition occurring in 0.005 to 0.01% of all pregnancies. As a result of the rarity of this condition, diagnosis, management, and monitoring will remain challenging especially in places with limited resources and expertise. The case we report is an interesting rare case which presented with well-described complications; only a few similar cases have been described to date...
May 21, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29779040/association-between-unexplained-thickened-nuchal-translucency-and-adverse-pregnancy-outcomes
#6
Santee Tiyatha, Sirinart Sirilert, Ratanaporn Sekararithi, Theera Tongsong
OBJECTIVE: To determine the association between unexplained increased nuchal translucency (INT) and adverse pregnancy outcomes. PATIENTS AND METHODS: The prospective database of our fetal down screening project was accessed to retrieve the records with NT measurement and complete follow-up. Pregnancies with pre-existing medical diseases, fetal chromosomal or structural abnormalities were excluded. The selected pregnancies were classified into the INT groups (> 95th percentile), the normal (< 95th percentile) group...
May 19, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29774596/epidemiological-analysis-of-maternal-lipid-levels-during-the-second-trimester-in-pregnancy-and-the-risk-of-adverse-pregnancy-outcome-adjusted-by-pregnancy-bmi
#7
Chao-Yan Yue, Chun-Mei Ying
BACKGROUND: Pregnancy is accompanied by profound changes in lipid metabolism. We aimed to assess whether effects of second trimester body mass index and maternal lipid concentrations are associated with an increased risk of adverse pregnancy outcomes. METHODS: We investigated the serum levels of maternal lipids during the second trimester in pregnancy, and analyzed associations between the lipid levels and the risk of adverse pregnancy outcome. Seven hundred and seventy-four pregnant women were enrolled in this study between February 2016 and June 2016...
May 17, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29769490/comparison-of-outcome-of-eclamptic-patient-following-vaginal-delivery-versus-caeserian-delivery-by-spinal-anaesthesia
#8
M A Hossain, R K Karmoker, M S Rahman, H O Rashid, S H Khan, M A Rahman
Eclampsia is a common problem in pregnancy in Bangladesh. It is a severe form of preeclampsia which affects 5 to 7% of pregnancies is a significant cause of maternal & neonatal morbidity & mortality. Pre-eclampsia when complicated with generalized tonic-clonic convulsions and/or coma is called eclampsia. The term eclampsia is derived from a Greek word, meaning "like a flash of lightening". It may occur quite abruptly, without any warning manifestations. Eclampsia is a major cause of maternal mortality & morbidity as well as foetal loss worldwide, particularly in the third world...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29766818/cell-free-fetal-dna-a-novel-biomarker-for-early-prediction-of-pre-eclampsia-and-other-obstetric-complications
#9
Naina Kumar, Amit Kant Singh
Hypertensive disorder of pregnancy, especially Pre-eclampsia is one of the major causes of increased maternal and perinatal morbidity and mortality all over the world. Early prediction of pre-eclampsia is the need of modern obstetrics, as this can timely prevent the progress of disease as well as related fetal and maternal morbidity and mortality. In addition to the screening of fetal aneuploidies, Rhesus-D status, fetal sex, single gene disorders, the cell-free fetal Deoxyribonucleic acid (DNA) quantification has emerged out as a promising biomarker for prediction of pre-eclampsia...
May 16, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29761476/comparison-of-materno-fetal-predictors-and-short-term-outcomes-between-early-and-late-onset-pre-eclampsia-in-the-low-income-setting-of-douala-cameroon
#10
Charlotte Tchente Nguefack, Annabel Ako Mangwi, Anastase Dzudie Tamdja, Théophile Nana Njamen, Paul Nkemtendong Tolefack, Emile Mboudou
OBJECTIVE: To describe and compare materno-fetal predictors and short-term outcomes of early onset pre-eclampsia (EOPE) and late onset pre-eclampsia (LOPE) in Douala, Cameroon. METHODS: The present prospective hospital-based cross-sectional study included women with pre-eclampsia attending obstetric units at four hospitals in Douala between December 1, 2016, and April 30, 2017. To determine maternal predictors, sociodemographic and medical data were recorded using a pretested questionnaire...
May 14, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29748651/advances-in-assessing-body-composition-during-pregnancy
#11
REVIEW
Jasper Most, Kara Lynn Marlatt, Abby Duhé Altazan, Leanne Maree Redman
The prevalence of excess gestational weight gain is increasing worldwide and is associated with pregnancy complications, including gestational diabetes mellitus, pre-eclampsia, preterm birth, macrosomia, and development of obesity in offspring. Whereas gestational weight gain positively correlates with the gain in fat mass (FM), fat-free mass (FFM) gain is relatively consistent across pregnancies. Commonly used methods to assess body composition include anthropometry, densitometry (air displacement plethysmography, underwater weighing), and hydrometry (isotope dilution, bioimpedance analysis)...
May 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29745991/association-of-pre-eclampsia-with-sod2-ala16val-polymorphism-among-mother-father-infant-triads
#12
Zhong-Cheng Luo, Pierre Julien, Shu-Qin Wei, Francois Audibert, William D Fraser
OBJECTIVE: To determine whether pre-eclampsia is associated with polymorphisms in superoxide dismutase (SOD) genes among mother-father-infant triads. METHODS: We did this follow-up cohort study at 17 urban hospitals in Canada between October 1, 2008, and September 30, 2010. We recruited Canadian participants who had participated in the International Trial of Antioxidant Supplementation for the Prevention of Pre-eclampsia. Saliva specimens were collected for DNA extraction...
May 10, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29741244/enhanced-th1-and-inflammatory-mrna-responses-upregulate-nk-cell-cytotoxicity-and-nkg2d-ligand-expression-in-human-pre-eclamptic-placenta-and-target-it-for-nk-cell-attack
#13
Marie-Therese Vinnars, Emma Björk, Ivan Nagaev, Ulrika Ottander, Katarina Bremme, Ulrika Holmlund, Eva Sverremark-Ekström, Lucia Mincheva-Nilsson
PROBLEM: Pre-eclampsia (PE), a severe human pregnancy disorder, is associated with exaggerated systemic inflammation, enhanced cytokine production, and increased shedding of microvesicles leading to endothelial dysfunction, coagulopathy, and extensive placenta destruction. The cause of PE is still unclear. Evidence suggests that its origin lies in the placenta and that the maternal immune system is involved. A shift in cytokine production in PE pregnancy promotes NK cell activation, suggested to be important in PE pathogenesis...
May 9, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29737875/the-discovery-of-protein-biomarkers-in-pre-eclmmpsia-the-promising-role-of-mass-spectrometry
#14
Lina A Dahabiyeh
CONTEXT: Pre-eclampsia (PE) is a common hypertensive disorder of pregnancy that substantially affects maternal and neonatal morbidity and mortality worldwide. The etiology of the disease remains poorly understood with lack of reliable diagnostic tests. PE is a multisystem disorder so it is very unlikely that a single or a small group of biomarkers will accurately predict the disease. Mass spectrometry (MS) is indispensable analytical tool in protein analysis studies. MS-based proteomics have the ability to detect the entire protein complement to provide a useful window into a range of biological processes and allow the identification of differentially expressed proteins between samples...
May 8, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29727040/how-is-the-human-umbilical-artery-regulated
#15
REVIEW
Margarida Lorigo, Melissa Mariana, Joana Feiteiro, Elisa Cairrao
The purpose of this review is to present an update of the main mechanisms involved in the physiological regulation of contraction and relaxation of the human umbilical artery (HUA) smooth muscle cells. A literature review was performed based on the analysis of papers available on PubMed. The most important and relevant studies regarding the regulation of the HUA are presented in this article. The vascular smooth muscle is a highly specialized structure, whose main function is to regulate the vascular tonus...
May 4, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29714512/association-of-angiotensin-receptor-2-gene-polymorphisms-with-pregnancy-induced-hypertension-risk
#16
Chenyang Li, Weijun Peng, Heng Zhang, Weirong Yan
OBJECTIVES: To investigate the association of polymorphisms and haplotypes of angiotensin receptor 2 (AT2R) gene with pregnancy induced hypertension (PIH) in Chinese Han women. METHODS: A case-control study was designed with 446 cases (gestational hypertension, GH: 124; pre-eclampsia, PE + eclampsia, E: 322) and 650 controls. rs5193, rs1403543 and rs12710567 of AT2R gene were genotyped. A logistic regression approach was applied to estimate the relationship between the polymorphisms and haplotypes of AT2Rgene with PIH risk...
May 1, 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29708884/serum-sflt-1-plgf-ratio-has-better-diagnostic-ability-in-early-compared-to-late-onset-pre-eclampsia
#17
Theng Theng Chuah, Wan Shi Tey, Mor Jack Ng, Edward T H Tan, Bernard Chern, Kok Hian Tan
BACKGROUND: To establish gestational specific cutoffs for the soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) ratio as a diagnostic tool for pre-eclampsia (PE) in an Asian population. METHODS: 82 subjects (48 PE patients and 34 controls) were recruited. sFlt-1 and PlGF were analysed on the Roche Cobas e411 analyzer and their ratio was calculated. Diagnostic performance was evaluated using receiver-operating characteristics (ROC) curves...
April 28, 2018: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/29707205/timely-referral-saves-the-lives-of-mothers-and-newborns-midwifery-led-continuum-of-care-in-marginalized-teagarden-communities-a-qualitative-case-study-in-bangladesh
#18
Animesh Biswas, Rondi Anderson, Sathyanarayanan Doraiswamy, Abu Sayeed Md Abdullah, Nabila Purno, Fazlur Rahman, Abdul Halim
Background: Prompt and efficient identification, referral of pregnancy related complications and emergencies are key factors to the reduction of maternal and newborn morbidity and mortality. As a response to this critical need, a midwifery led continuum of reproductive health care was introduced in five teagardens in the Sylhet division, Bangladesh during 2016. Within this intervention, professional midwives provided reproductive healthcare to pregnant teagarden women in the community.  This study evaluates the effect of the referral of pregnancy related complications...
2018: F1000Research
https://www.readbyqxmd.com/read/29704394/identification-of-uterine-pacemaker-regions-at-the-myometrial-placental-interface-in-the-rat
#19
E Josiah Lutton, Wim J E P Lammers, Sean James, Hugo A van den Berg, Andrew M Blanks
Coordinated contraction of the uterine smooth muscle is essential to parturition. Histologically and physiologically defined pacemaker structures have not been identified in uterine smooth muscle. Here we report combined electrophysiological and histological evidence of zones associated with pacemaker activity in the rat myometrium (MPPZ = myometrial/placental pacemaking zone) Our method relies crucially on the integration of histological and electrophysiological data in an in silico 3-dimensional reconstruction of the rat myometrium at 10 micrometer resolution We find that MPPZs are closely related with placental sites and the area of disruptive myometrial remodelling surrounding such sites If analogues of the MPPZ are present in the human, defining their histology and physiology will be important steps towards treatment of pre-term birth, pre-eclampsia, and post-partum haemorrhage ABSTRACT: Coordinated uterine contractions are essential for delivering viable offspring in mammals...
April 28, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29700870/the-cost-effectiveness-of-first-trimester-screening-and-early-preventative-use-of-aspirin-in-women-at-high-risk-of-early-onset-pre-eclampsia
#20
Dayne Ortved, T Lee-Ann Hawkins, Jo-Ann Johnson, Jon Hyett, Amy Metcalfe
OBJECTIVE: Pre-eclampsia (PE) remains a leading cause of maternal and fetal morbidity and mortality. A first trimester screening algorithm predicting the risk of early onset PE has been developed and validated. Early prediction coupled with initiation of aspirin at 11 to 13 weeks in women identified as high risk is effective at reducing the prevalence of early onset PE. The aim of this study is to evaluate the cost-effectiveness of this first trimester screening program coupled with early use of low-dose aspirin in women at high risk of developing early onset PE versus current practice...
April 27, 2018: Ultrasound in Obstetrics & Gynecology
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