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Eclampsia pre eclampsia

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https://www.readbyqxmd.com/read/28938051/pregnancy-disorders-in-africa-and-the-obstetric-dilemma
#1
Annettee Nakimuli, Ashley Moffett
The high neonatal and maternal morbidity and mortality associated with the extremes of birth weight is referred to as the obstetric dilemma. Pre-eclampsia and other conditions that lead to low birth weight are considered as the Great Obstetrical Syndromes (GOS). At the other extreme is high birth weight resulting in obstructed labour. Fetal weight largely depends on placental function and defective placentation is a common feature of the GOS. There is evidence that the local uterine immune system (KIR and HLA-C) regulates placentation, with racial differences noted...
December 1, 2016: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28929598/levels-of-serum-circulating-angiogenic-factors-within-1-week-prior-to-delivery-are-closely-related-to-conditions-of-pregnant-women-with-pre-eclampsia-gestational-hypertension-and-or-fetal-growth-restriction
#2
Sakiko Nanjo, Sawako Minami, Mika Mizoguchi, Madoka Yamamoto, Tamaki Yahata, Saori Toujima, Michihisa Shiro, Aya Kobayashi, Yasuteru Muragaki, Kazuhiko Ino
AIM: We aimed to investigate maternal serum angiogenic marker profiles within 1 week prior to delivery in cases of gestational hypertension (GH), pre-eclampsia (PE), and/or fetal growth restriction (FGR) with different clinical conditions. METHODS: We enrolled 165 women with singleton pregnancy. The participants were classified based on three characteristics: (i) proteinuria (GH and PE); (ii) FGR (PE with FGR [PE + FGR], PE alone, and FGR alone); and (iii) onset (early onset PE [EO PE] and late-onset PE [LO PE])...
September 20, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28926728/a-retrospective-cohort-review-of-intrahepatic-cholestasis-of-pregnancy-in-a-south-australian-population
#3
Jessica A Marathe, Wei How Lim, Michael P Metz, Wendy Scheil, Gustaaf A Dekker, William M Hague
OBJECTIVE: To review the management and outcomes of Intrahepatic Cholestasis of Pregnancy (ICP) in South Australia (SA) over the past decade. DESIGN: Retrospective cohort review. SETTING: Public clinics at two teaching hospitals in SA. POPULATION: All pregnancies associated with ICP (defined as pruritus with serum bile acids≥10μmol/L) managed 2001-2010. METHODS: Identification of subjects (laboratory database), detailed chart-review to ascertain demographics, maternal/perinatal outcomes and associated pregnancy comorbidities, analysis of mild/severe disease cohorts, comparison with normal population data, using Student's t-test or Mann-Whitney U test as appropriate for continuous variables, and Pearson's chi-square test or Fisher's exact test for categorical variables...
September 14, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28924318/pre-eclampsia-molecular-events-to-biomarkers
#4
REVIEW
Kavita Sahai, Seema Saraswathy, Tribhuvan Pal Yadav, Devendra Arora, Manu Krishnan
Pre-eclampsia is a hypertensive disorder in pregnancy, which accounts for 10-15% of the maternal and perinatal mortality worldwide. Abnormal placental development and tissue hypoxia are its main etiologic factors. The present diagnostic methods of blood pressure monitoring and renal function evaluation are insufficient in the early detection of pre-eclampsia. Since molecular events portent well ahead of the disease onset, biomarker research for the early diagnosis of pre-eclampsia has recently generated ambitious clinical targets...
April 2017: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/28921798/pre-eclampsia-is-primarily-a-placental-disorder-against-pre-eclampsia-the-heart-matters
#5
Basky Thilaganathan
No abstract text is available yet for this article.
October 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28921791/pre-eclampsia-is-primarily-a-placental-disorder-for-pre-eclampsia-is-primarily-a-placental-disorder
#6
Stefan Verlohren
No abstract text is available yet for this article.
October 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28917582/preterm-pre-eclampsia-what-every-neonatologist-should-know
#7
REVIEW
Lisa Story, Lucy C Chappell
Although pre-eclampsia affects 5-10% of pregnancies globally and is responsible for substantial maternal and perinatal morbidity and mortality, currently there is no cure other than delivery of the baby. Predictive screening tests based on clinical risk factors, with or without the addition of biomarkers and imaging, have been developed, but adoption into clinical practice is limited by suboptimal test performance. Once established pre-eclampsia is diagnosed, a woman is usually managed expectantly prior to 37weeks' gestation to reduce perinatal morbidity and mortality associated with iatrogenic prematurity until maternal or fetal triggers for delivery mean that risks of pregnancy prolongation outweigh the benefits...
September 13, 2017: Early Human Development
https://www.readbyqxmd.com/read/28915802/determinants-of-pre-eclampsia-eclampsia-among-women-attending-delivery-services-in-selected-public-hospitals-of-addis-ababa-ethiopia-a-case-control-study
#8
Teklit Grum, Abiy Seifu, Mebrahtu Abay, Teklit Angesom, Lidiya Tsegay
BACKGROUND: Pre-eclampsia is a pregnancy-specific hypertensive disorder usually occurs after 20 weeks of gestation. It is one of the leading causes of maternal and perinatal morbidity and mortality worldwide. In Ethiopia, the major direct obstetric complications including pre-eclampsia/eclampsia account for 85% of the maternal deaths. Unlike deaths due to other direct causes, pre-eclampsia/ eclampsia related deaths appear to be increasing and linked to multiple factors, making prevention of the disease a continuous challenge...
September 15, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28913824/a-randomised-controlled-trial-of-consumption-of-dark-chocolate-in-pregnancy-to-reduce-pre-eclampsia-difficulties-in-recruitment-allocation-and-adherence
#9
Subashini Gnanendran, Jemma Porrett, Cindy Woods, Maryke Buttrose, Clare Jukka, Jane Hollins, Stephen Robson, Caroline de Costa
In 2013-2014 we undertook a randomised controlled trial (RCT) to determine whether the daily ingestion of dark chocolate during pregnancy could reduce the incidence of pre-eclampsia in primigravidae. However, after two years we had not succeeded in recruiting more than 3.5% of the number of participants required to answer the research question, and the trial was halted. We also reviewed the literature on this topic and found it to be limited. We report here our findings and discuss the difficulties facing researchers in this area...
September 15, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28911253/comment-on-maternal-pre-eclampsia-as-a-risk-factor-for-necrotizing-enterocolitis
#10
Jiale Chen
No abstract text is available yet for this article.
September 14, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28911026/response-to-using-carbon-monoxide-releasing-molecules-in-models-of-pre-eclampsia-when-should-we-be-monitoring-vascular-effects
#11
Eric M George, Joey P Granger
No abstract text is available yet for this article.
October 1, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28906533/cardiac-diastolic-function-after-recovery-from-pre-eclampsia
#12
P Soma-Pillay, M C Louw, A O Adeyemo, J Makin, R C Pattinson
BACKGROUND: Pre-eclampsia is associated with significant changes to the cardiovascular system during pregnancy. Eccentric and concentric remodelling of the left ventricle occurs, resulting in impaired contractility and diastolic dysfunction. It is unclear whether these structural and functional changes resolve completely after delivery. AIMS: The objective of the study was to determine cardiac diastolic function at delivery and one year post-partum in women with severe pre-eclampsia, and to determine possible future cardiovascular risk...
August 31, 2017: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/28905692/the-emerging-challenge-of-optimal-blood-pressure-management-and-hypertensive-syndromes-in-pregnant-women-with-sickle-cell-disease-a-review
#13
Nabilah F Lari, Michael R DeBaun, Samuel A Oppong
Sickle cell disease (SCD) is the most common hemoglobinopathy, affecting a considerable proportion of black populations of African origin, Middle East and in the Indian sub-continent. Women with SCD are more likely to experience adverse pregnancy and delivery outcomes. Hypertensive diseases in pregnancy such as preeclampsia and eclampsia are more common in women with sickle cell disease. Areas covered: This review examined the influence of hypertension and SCD in pregnancy, and provides the preliminary evidence that the traditional systolic and diastolic blood pressure thresholds for hypertensive disorders such as pre-eclampsia and eclampsia may require reassessment in pregnant women with SCD...
September 14, 2017: Expert Review of Hematology
https://www.readbyqxmd.com/read/28890543/the-altered-pd-1-pd-l1-pathway-delivers-the-one-two-punch-effects-to-promote-the-treg-th17-imbalance-in-pre-eclampsia
#14
Yonghong Zhang, Zhaozhao Liu, Mei Tian, Xiaohui Hu, Liling Wang, Jinlu Ji, Aihua Liao
The programmed cell death-1 (PD-1)/PD-ligand 1 (PD-L1) pathway is critical for normal pregnancy by promoting regulatory T (Treg) cell development and inhibiting the Th17 response. However, the relationship between the PD-1/PD-L1 pathway and the Treg/Th17 imbalance in pre-eclampsia (PE) is an enigma. In this study, decreased PD-1 and PD-L1 expression and a Treg/Th17 imbalance were observed at the maternal-fetal interface in PE. The regulatory effects of the PD-1/PD-L1 pathway on the Treg and Th17 cell quantities were determined in vitro by targeting T-cell proliferation, differentiation and transdifferentiation...
September 11, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28882581/premature-ovarian-senescence-and-high-miscarriage-rate-impair-fertility-in-women-with-hepatitis-c-virus-infection
#15
Aimilia Karampatou, Xue Han, Loreta A Kondili, Gloria Taliani, Alessia Ciancio, Filomena Morisco, Rosina Maria Critelli, Enrica Baraldi, Veronica Bernabucci, Giulia Troshina, Maria Guarino, Simonetta Tagliavini, Federica D'Ambrosio, Laura Bristot, Laura Turco, Stefano Rosato, Stefano Vella, Tommaso Trenti, Isabella Neri, Antonio La Marca, Shivaji Manthena, Andrea S Goldstein, Savino Bruno, Yanjun Bao, Yuri Sanchez Gonzalez, Erica Villa
BACKGROUND AND AIMS: Premenopausal Hepatitis C Virus positive (HCV+) women have failing ovarian function.We thus investigated reproductive history,risk of infertility and pregnancy outcomes in HCV+ women of childbearing age. METHODS: Three different groups were studied:1) Clinical cohort:100 HCV+ women with chronic liver disease (CLD), age matched with 50 HBV+ women with CLD and with 100 healthy women consecutively observed in 3 Italian Gastroenterology Units;2) 1998 HCV+ women enrolled in the Italian Platform for the Study of Viral Hepatitis Therapies (PITER);3) 6...
September 4, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28877712/ten-years-analysis-of-stillbirth-in-a-tertiary-hospital-in-sub-sahara-africa-a-case-control-study
#16
Paul Nkemtendong Tolefac, Rita Frinue Tamambang, Eugene Yeika, Lawrence Tanyi Mbwagbaw, Thomas Obinchemti Egbe
OBJECTIVE: Stillbirth measures provide means to assess adequacy of maternal and perinatal care in a given population. The aim of this study was to describe the determinants of stillbirth in Douala general hospital, Cameroon. RESULTS: Determinants of stillbirth in this hospital are: maternal age ≥35 years (OR 1.79, 95% CI 1.26-2.54, p = 0.001), pre-eclampsia/eclampsia (OR 2.97, 95% CI 0.87-8.89, p value of 0.03), diabetes in pregnancy (OR 9.97, 95% CI 1.15-86...
September 6, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28877675/signal-functions-for-emergency-obstetric-care-as-an-intervention-for-reducing-maternal-mortality-a-survey-of-public-and-private-health-facilities-in-lusaka-district-zambia
#17
Tannia Tembo, Gershom Chongwe, Bellington Vwalika, Lungowe Sitali
BACKGROUND: Zambia's maternal mortality ratio was estimated at 398/100,000 live births in 2014. Successful aversion of deaths is dependent on availability and usability of signal functions for emergency obstetric and neonatal care. Evidence of availability, usability and quality of signal functions in urban settings in Zambia is minimal as previous research has evaluated their distribution in rural settings. This survey evaluated the availability and usability of signal functions in private and public health facilities in Lusaka District of Zambia...
September 6, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28876491/longitudinal-changing-values-of-the-sflt-1-plgf-ratio-in-singleton-pregnancies-with-early-onset-fetal-growth-restriction
#18
I Herraiz, M S Quezada, J Rodriguez-Calvo, E Gómez-Montes, C Villalaín, A Galindo
OBJECTIVE: To describe, in singleton pregnancies complicated with early-onset fetal growth restriction (FGR), the progressing values of the sFlt-1/PlGF ratio in the weeks prior to delivery, differentiating cases with and without pre-eclampsia (PE). METHODS: Prospective cohort observational study of early-onset FGR cases followed with maternal serum determinations of the sFlt-1/PlGF ratio from diagnosis to delivery. Measurements were made at weekly intervals and within the last 48 hours before birth...
September 6, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28875223/circulating-adipokines-are-associated-with-pre-eclampsia-in-women-with-type-1-diabetes
#19
Clare B Kelly, Michelle B Hookham, Jeremy Y Yu, Samuel M Lockhart, Mei Du, Alicia J Jenkins, Alison Nankervis, Kristian F Hanssen, Tore Henriksen, Satish K Garg, Samar M Hammad, James A Scardo, Christopher E Aston, Christopher C Patterson, Timothy J Lyons
AIMS/HYPOTHESIS: The incidence of pre-eclampsia, a multisystem disorder of pregnancy, is fourfold higher in type 1 diabetic than non-diabetic women; it is also increased in women with features of the metabolic syndrome and insulin resistance. In a prospective study of pregnant women with type 1 diabetes, we measured plasma levels of adipokines known to be associated with insulin resistance: leptin, fatty acid binding protein 4 (FABP4), adiponectin (total and high molecular weight [HMW]; also known as high molecular mass), retinol binding protein 4 (RBP4) and resistin and evaluated associations with the subsequent development of pre-eclampsia...
September 5, 2017: Diabetologia
https://www.readbyqxmd.com/read/28871951/-inhibition-of-mir-18a-increases-expression-of-estrogen-receptor-1-and-promotes-apoptosis-in-human-htr8-trophoblasts
#20
Yang Yang, Shaohua Zhang, Yajun Li, Bin Han, Yuan Ma
Objective To investigate the role of pre-eclampsia related miR-18a in regulating estrogen receptor 1 (ER1) expression, cell cycle and apoptosis in HTR8 human trophoblasts. Methods HTR8 cells were transfected with synthesized negative control (NC) miRNA, miR-18a and miR-18a inhibitor, respectively. The mRNA expressions of miR-18a and ER1 were determined by reverse transcription PCR (RT-PCR). The protein expression level of ER1 was examined by Western blotting. The cell cycle and apoptosis were evaluated by flow cytometry...
August 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
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