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https://www.readbyqxmd.com/read/28646411/achievement-of-glycated-hemoglobin-goals-in-the-us-remains-unchanged-through-2014
#1
Ginger Carls, Johnny Huynh, Edward Tuttle, John Yee, Steven V Edelman
INTRODUCTION: Previous research has found that the percentage of US adults with diabetes achieving a glycated hemoglobin (HbA1c) target of <7.0% with currently available treatments has been fairly constant from 2003 to 2010, remaining at just over 50% [1]. The objective of this study was to compare the most recent data (2011-2014) with earlier data to track progress on HbA1c target achievement, for both the general target of <7.0% and inferred individualized targets based on age and the presence of complications...
June 23, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28646377/efficacy-of-an-education-course-delivered-to-community-health-workers-in-diabetes-control-a-randomized-clinical-trial
#2
Camila Furtado de Souza, Mériane Boeira Dalzochio, Alessandra Teixeira Netto Zucatti, Rosana De Nale, Marília Tavares de Almeida, Jorge Luiz Gross, Cristiane Bauermann Leitão
BACKGROUND: Community health workers are community members who provide education and care for patients for a broad range of health issues, including diabetes mellitus. However, few community health workers are trained for diabetes education and little is known about the effectiveness of their interventions. The aim of this study is to evaluate the effect of a diabetes education program delivered to community health workers in improving the metabolic control of patients with type 2 diabetes mellitus...
June 23, 2017: Endocrine
https://www.readbyqxmd.com/read/28645890/tailored-communication-within-mobile-apps-for-diabetes-self-management-a-systematic-review
#3
Heidi Holmen, Astrid Klopstad Wahl, Milada Cvancarova Småstuen, Lis Ribu
BACKGROUND: The prevalence of diabetes is increasing and with the requirements for self-management and risk of late complications, it remains a challenge for the individual and society. Patients can benefit from support from health care personnel in their self-management, and the traditional communication between patients and health care personnel is changing. Smartphones and apps offer a unique platform for communication, but apps with integrated health care personnel communication based on patient data are yet to be investigated to provide evidence of possible effects...
June 23, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28645260/within-class-differences-in-cancer-risk-for-sulfonylurea-treatments-in-patients-with-type-2-diabetes-zodiac-55-a-study-protocol
#4
Dennis Schrijnders, Geertruida H de Bock, Sebastiaan T Houweling, Kornelis J J van Hateren, Klaas H Groenier, Jeffrey A Johnson, Henk J G Bilo, Nanne Kleefstra, Gijs W D Landman
BACKGROUND: Patients with type 2 diabetes (T2D) are at increased risk for developing cancer. As approximately 8% of the world's population is living with T2D, even a slight increase in cancer risk could result in an enormous impact on the number of persons developing cancer. In addition, several glucose lowering drug classes for treating patients with T2D have been associated with a difference in risk of cancer overall, and especially for obesity related cancers. In what way and to what degree cancer risk is modified by the use of different sulfonylureas (SU) is unclear...
June 23, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28645109/elevated-hemoglobin-glycation-index-identify-non-diabetic-individuals-at-increased-risk-of-kidney-dysfunction
#5
Teresa Vanessa Fiorentino, Maria Adelaide Marini, Elena Succurro, Angela Sciacqua, Francesco Andreozzi, Francesco Perticone, Giorgio Sesti
Hemoglobin glycation index (HGI), calculated as the difference between the observed value of HbA1 and the predicted HbA1c based on plasma glucose concentration, is a measure of the individual tendency toward non-enzymatic hemoglobin glycation which has been found to be positively associated with nephropathy in subjects with diabetes. In this cross-sectional study we aimed to evaluate whether higher HGI levels are associated with impaired kidney function also among nondiabetic individuals.The study group comprised 1505 White nondiabetic individuals stratified in quartiles according to HGI levels...
June 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28644095/impact-of-adherence-to-antidepressants-on-healthcare-outcomes-and-costs-among-patients-with-type-2-diabetes-and-comorbid-major-depressive-disorder
#6
Charles Vega, Russell V Becker, Lisa Mucha, Betty H Lorenz, Michael T Eaddy, Augustina O Ogbonnaya
OBJECTIVE: To evaluate the association between adherence to antidepressants and an effect on clinical outcomes and healthcare costs in patients with major depressive disorder (MDD) and comorbid type 2 diabetes (T2D). METHODS: This retrospective study used MarketScan claims data from January 2012 to March 2014. Study entry was the first claim for an antidepressant and a diagnosis code for MDD and T2D in the prior 6 months. Adherence and persistence to antidepressant therapy in the first 180 days were defined as medication possession ratio (MPR) ≥80% and length of therapy (LOT), with no treatment gap of >15 days, respectively...
June 23, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28644050/hba1c-analysis-by-capillary-electrophoresis-comparison-with-chromatography-and-an-immunological-method
#7
Olav Klingenberg, Torill Furuset, Camilla R Hestbråten, Marit H Hallberg, Astrid Steiro, Iren R Orset, Jens P Berg
BACKGROUND: Haemoglobin A1c (HbA1c) has become an even more important analyte for clinical laboratories during recent years with the introduction of its diagnostic use for diabetes mellitus. Several different analytical principles can be used, each with their advantages and disadvantages. AIM: We wanted to compare Sebia Capillarys 2 Flex Piercing (Capillarys) with our routine HbA1c methods, which were an HPLC method (Tosoh G7) and an immunoassay (Tina-Quant on Roche Modular P) by analysing a large clinical material...
June 23, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28643671/-health-literacy-and-diabetes-control-in-patients-attending-a-university-outpatient-clinic-in-argentina
#8
Alexander Ariza Bolivar, Martín E Lanteri, Carla Y Cícero, Adriana Pérez, Félix M Puchulu, Raúl Mejía
Health literacy (HL) is a measure of a patient ability to read, understand and to take decisions on medical instructions. Patients with inadequate HL have poorer health outcomes than those with adequate HL. There is little information on HL levels in diabetic patients in Argentina. The aim of this study was to explore the association between HL and glycemic control in diabetic patients from a university hospital in Argentina. HL was assessed with the Short Assessment of Health Literacy for Spanish-speaking Adults (SAHLSA), glycemic control through glycosylated hemoglobin A1c (HbA1c); 156 patients (58% women) took part in the study...
2017: Medicina
https://www.readbyqxmd.com/read/28643425/ideglira-was-effective-across-a-range-of-dysglycaemia-and-bmi-categories-in-the-dual-v-randomized-trial
#9
Ildiko Lingvay, Stewart Harris, Elmar Jaeckel, Keval Chandarana, Mattis F Ranthe, Esteban Jódar
This study assessed the efficacy of insulin degludec/liraglutide (IDegLira) versus insulin glargine U100 (IGlar) across categories of baseline HbA1c (≤7.5%, >7.5- ≤ 8.5% and >8.5%), body mass index (BMI; <30, ≥30- < 35 and ≥35 kg/m(2) ) and fasting plasma glucose (FPG; <7.2 and ≥7.2 mmol/L) in patients with type 2 diabetes (T2D) uncontrolled on basal insulin, using post hoc analyses of the DUAL V 26-week trial. With IDegLira, mean HbA1c was reduced across all baseline HbA1c (1...
June 23, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28643356/bimagrumab-improves-body-composition-and-insulin-sensitivity-in-insulin-resistant-subjects
#10
Tania Garito, Ronenn Roubenoff, Marcus Hompesch, Linda Morrow, Katherine Gomez, Daniel Rooks, Charles Meyers, Monte Buchsbaum, Srikanth Neelakantham, Therese Swan, Lee Anne Filosa, Didier Laurent, Olivier Petricoul, Marjorie Zakaria
BACKGROUND: Skeletal muscle is a key mediator of insulin resistance. Bimagrumab, an antibody against activin receptor type II (ActRII), prevents binding of negative muscle regulators, like myostatin, and increases lean mass and decreases fat mass in animal models. OBJECTIVE: We hypothesized that an improving body composition in insulin resistant individuals could enhance insulin sensitivity. METHODS: Sixteen individuals with mean body mass index (BMI) = 29...
June 23, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28643293/-why-is-a-combination-of-basal-insulin-with-a-glp-1-receptor-agonist-useful-in-many-patients-with-type-2-diabetes
#11
Michael Nauck, Birgit Wilhelm
BACKGROUND: In 2015, the combination of basal insulin and GLP-1 receptor agonist (RA) was incorporated into the guideline recommendations for type 2 diabetes as an option for the last escalation step. The two antidiabetics to be injected subcutaneously are complementary regarding their respective main effects and limitations. Basal insulin is predominantly active between meals and in the fasting state, whereas the main action of GLP-1 RA consists in preventing an excessive postprandial blood glucose increase...
June 2017: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/28643218/empagliflozin-improves-left-ventricular-diastolic-dysfunction-in-a-genetic-model-of-type-2-diabetes
#12
Nadjib Hammoudi, Dongtak Jeong, Rajvir Singh, Ahmed Farhat, Michel Komajda, Eric Mayoux, Roger Hajjar, Djamel Lebeche
PURPOSE: Cardiovascular (CV) diseases in type 2 diabetes (T2DM) represent an enormous burden with high mortality and morbidity. Sodium-glucose cotransporter 2 (SGLT2) inhibitors have recently emerged as a new antidiabetic class that improves glucose control, as well as body weight and blood pressure with no increased risk of hypoglycemia. The first CV outcome study terminated with empagliflozin, a specific SGLT2 inhibitor, has shown a reduction in CV mortality and in heart failure hospitalization, suggesting a beneficial impact on cardiac function which remains to be demonstrated...
June 22, 2017: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/28642211/the-integrating-depression-and-diabetes-treatment-independent-study-design-and-methods-to-address-mental-healthcare-gaps-in-india
#13
A J Kowalski, S Poongothai, L Chwastiak, M Hutcheson, N Tandon, R Khadgawat, G R Sridhar, S R Aravind, B Sosale, R M Anjana, D Rao, R Sagar, N Mehta, K M V Narayan, J Unutzer, W Katon, V Mohan, M K Ali
INTRODUCTION: Depression and diabetes are highly prevalent worldwide and often co-exist, worsening outcomes for each condition. Barriers to diagnosis and treatment are exacerbated in low and middle-income countries with limited health infrastructure and access to mental health treatment. The INtegrating DEPrEssioN and Diabetes treatmENT (INDEPENDENT) study tests the sustained effectiveness and cost-effectiveness of a multi-component care model for individuals with poorly-controlled diabetes and depression in diabetes clinics in India...
June 19, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28641786/association-of-apolipoprotein-ciii-apoc-iii-endothelium-dependent-vasodilation-and-peripheral-neuropathy-in-a-multi-ethnic-population-with-type-2-diabetes
#14
Sharon Li Ting Pek, Chee Fang Sum, Lee Ying Yeoh, Simon Biing Ming Lee, Wern Ee Tang, Su Chi Lim, Subramaniam Tavintharan
BACKGROUND: Diabetic peripheral neuropathy (DPN) is a common complication of Type 2 diabetes (T2D). Apart from hyperglycemia, its pathogenesis is poorly understood. Apolipoprotein-CIII (apoC-III) associated with triglyceride metabolism, is a risk factor for cardiovascular disease. Its role in DPN is not well-established. We studied the associations of apoC-III, endothelial function and DPN. METHODS: In patients with T2D, anthropometric data, fasting blood, and urine were collected for biochemistry and urine albumin/creatinine measurements (uACR)...
July 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28641783/abnormal-levels-of-adipokines-in-adolescent-offspring-of-women-with-type-1-diabetes-results-from-the-epicom-study
#15
Zuzana Lohse, Birgitte Bytoft, Sine Knorr, Tine D Clausen, Rikke Beck Jensen, Henning Beck-Nielsen, Anne Pernille Hermann, Peter Oturai, Jan Frystyk, Peter Damm, Claus H Gravholt, Kurt Højlund, Dorte M Jensen
AIMS/HYPOTHESIS: To investigate long-term consequences of diabetes during pregnancy, we determined adiponectin and leptin levels in adolescents born by women with type 1 diabetic (T1D) or non-diabetic mothers, and determined associations between adiponectin and leptin levels in adolescence and the magnitude of intrauterine hyperglycemia. RESEARCH DESIGN AND METHODS: We measured serum adiponectin and leptin and calculated leptin to adiponectin ratio (LAR) in 271 offspring of T1D women (index offspring) (13-20years), and 297 matched control offspring...
July 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28641407/efficacy-of-ezetimibe-combined-with-atorvastatin-in-treatment-of-carotid-artery-plaque-in-patients-with-type-2-diabetes-mellitus-complicated-with-coronary-heart-disease
#16
Jing Wang, Xiao-Bo Ai, Fei Wang, Yao-Wu Zou, Li Li, Xiao-Lei Yi
BACKGROUND: To evaluate the efficacy of ezetimibe combined with atorvastatin in treatment of carotid artery plaque in patients with type 2 diabetes mellitus complicated with coronary heart disease (CHD). METHODS: A total of 100 patients with carotid atherosclerosis (CAS) confirmed by ultrasound and diagnosed with type 2 diabetes mellitus and CHD were randomly assigned to atorvastatin group (atorvastatin 20 mg/d) or combined treatment group (ezetimibe 10 mg/d and atorvastatin 20 mg/d)...
June 21, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28640379/comparative-and-correlative-assessments-of-cytokine-complement-and-antibody-patterns-in-pediatric-type-1-diabetes
#17
M Abdel-Latif, A A Abdel-Moneim, M H El-Hefnawy, R G Khalil
One of the most widespread and effective environmental factors is the infection with enteroviruses (EVs) which accelerate β - cell destruction in type 1 diabetes (T1D). This study represented a comparison between diabetic EV(+) and EV- children as well as correlation analysis between autoantibodies, T1D markers, cytokines, complement activation products and anti- coxsackievirus (CV) IgG. EV RNA was detected in Egyptian children with T1D (26.2%) and healthy controls (0%). Detection of anti - CV IgG in T1D - EV(+) resulted in 64% positivity...
June 22, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28640213/the-association-of-serum-25-hydroxyvitamin-d-concentrations-and-elevated-glycated-hemoglobin-values-a-longitudinal-study-of-non-diabetic-participants-of-a-preventive-health-program
#18
Lalani L Munasinghe, Marco F Mastroeni, Silmara S B S Mastroeni, Sarah A Loehr, John Paul Ekwaru, Paul J Veugelers
The prevalence of Type 2 Diabetes (T2D) is sharply on the rise, both in Canada and worldwide. As addressing its root causes, i.e., promotion of healthy lifestyles and weight management, has been largely unsuccessful, new clues for primary prevention seem essential to curbing the increasing public health burden of T2D. In the present study, we examined whether improvements in vitamin D status, i.e., serum 25-hydroxyvitamin D [25(OH)D] concentrations, are paralleled by a reduction in the risk for reaching adverse glycated hemoglobin (HbA1c) levels in a community sample of non-diabetic volunteers participating in a preventive health program that encourages the use of vitamin D...
June 22, 2017: Nutrients
https://www.readbyqxmd.com/read/28640060/individualized-estimation-of-physical-activity-in-older-adults-with-type-2-diabetes
#19
Whitney A Welch, Neil Alexander, Ann M Swartz, Nora E Miller, Erica Twardzik, Scott J Strath
PURPOSE: Compare physical activity intensity in older adults with T2DM using individualized, relative cutpoints with standard, absolute cutpoints. METHODS: One hundred older adults with T2DM (68.9±5.1y, 65% male, 32.7±6.3 kgm, 7.2±1.1% HbA1c) completed a two-speed walking protocol (varying, walking between 1-2.5 mph), followed by a modified Bruce peak exercise test. Participants wore an accelerometer-based physical activity monitor at their waist and oxygen consumption was measured...
June 21, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28639974/an-evaluation-of-cardioprevent-a-technology-enabled-health-behavior-change-program-for-the-global-reduction-of-cardiovascular-risk
#20
Stephanie A Prince, Robert D Reid, Andrew L Pipe, Lisa A McDonnell
PURPOSE OF REVIEW: Cardiovascular diseases (CVDs) are the leading cause of mortality globally. Primary CVD prevention programs have the potential to improve risk factor profiles and, ultimately, the risk of developing CVD. The present study presents an evaluation of CardioPrevent, a global cardiovascular risk reduction program. RECENT FINDINGS: Of the 478 participants enrolled in the CardioPrevent program, 308 and 236 had complete 6-month and 12-month data, respectively at the time of evaluation...
July 20, 2017: Current Opinion in Cardiology
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