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https://www.readbyqxmd.com/read/29679801/metabolic-control-apoe-genotypes-and-dyslipidemia-in-children-adolescents-and-young-adults-with-type-1-diabetes
#1
Maddalena Macedoni, Tinka Hovnik, Emil Plesnik, Primoz Kotnik, Natasa Bratina, Tadej Battelino, Urh Groselj
BACKGROUND AND AIMS: Limited data is available on the factors influencing the lipid profiles and the prevalence of dyslipidemia in children, adolescents and young adults with type 1 diabetes. We aimed at assessing the influences of metabolic control and ApoE genotypes on lipid profiles and the prevalence of dyslipidemia in children, adolescents and young adults with type 1 diabetes. METHODS: Children, adolescents and young adults with type 1 diabetes from our nationwide cohort attending the annual check-up were prospectively included...
April 12, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29679620/longitudinal-association-between-periodontitis-and-development-of-diabetes-running-title-periodontitis-and-diabetes-development
#2
Kaumudi J Joshipura, Francisco J Muñoz-Torres, Bruce A Dye, Brian G Leroux, Margarita Ramírez-Vick, Cynthia M Pérez
BACKGROUND: Clinical trials have shown very modest short-term improvements in glycemic control among participants with diabetes after periodontitis treatment. Few longitudinal studies suggest that periodontitis may be related to prediabetes/diabetes risk. METHODS: We evaluated 1,206 diabetes free participants in the San Juan Overweight Adults Longitudinal Study (SOALS) and 941 with complete 3-year follow-up data were included. The National Health and Nutrition Examination Survey (NHANES) methods were used to assess periodontitis...
April 18, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29679479/health-care-disparities-between-men-and-women-with-type-2-diabetes
#3
Marady Sabiaga Mesa
INTRODUCTION: Regular medical checkups indicate a patient's level of adherence to health care treatment, and the frequency of cancelled appointments or no-shows can indicate adherence. This study investigated the use of health care services by men and women and its impact on the control of their type 2 diabetes. METHODS: This study observed 100 patients with type 2 diabetes aged 45 years or older who lived in Ventura County, California, during January 1, 2015, to January 31, 2016...
April 19, 2018: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29679149/totally-endoscopic-implant-to-effect-a-gastric-bypass-12-month-safety-and-efficacy-outcomes
#4
Bryan J Sandler, Laurent Biertho, Mehran Anvari, Roberto Rumbaut, Luis Alonso Morales-Garza, Gustavo Torres-Barrera, Simon Marceau, Dennis Hong, C Daniel Smith, Santiago Horgan
BACKGROUND: Only a small percentage of candidates for bariatric surgery ever undergo a procedure for weight loss. Devices duplicating key effects of bariatric surgeries with removable, fully trans-oral implants could extend their benefits to patients unwilling to undergo anatomy-altering abdominal surgeries. METHODS: Thirty-two obese subjects (mean BMI: 42.3) were enrolled in a prospective, multicenter, single-arm, feasibility trial of the first fully trans-oral endoscopic gastrointestinal bypass device...
April 20, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29678867/effect-of-the-duodenal-jejunal-bypass-liner-on-glycemic-control-in-patients-with-type-2-diabetes-with-obesity-a-meta-analysis-with-secondary-analysis-on-weight-loss-and-hormonal-changes
#5
REVIEW
Pichamol Jirapinyo, Andrea V Haas, Christopher C Thompson
OBJECTIVE: Duodenal-jejunal bypass liner (DJBL) is an endoscopic device that may mimic small bowel mechanisms of Roux-en-Y gastric bypass (RYGB). Previous studies have demonstrated the efficacy of DJBL at inducing weight loss. We assessed the effect of DJBL on glycemic control in patients with type 2 diabetes (T2D) with obesity. RESEARCH DESIGN AND METHODS: Data sources included MEDLINE, EMBASE, and Web of Science through 1 July 2017. Included were published studies that assessed DJBL outcomes in obese T2D patients...
May 2018: Diabetes Care
https://www.readbyqxmd.com/read/29678865/economic-evaluation-of-quality-improvement-interventions-designed-to-improve-glycemic-control-in-diabetes-a-systematic-review-and-weighted-regression-analysis
#6
REVIEW
Teryl K Nuckols, Emmett Keeler, Laura J Anderson, Jonas Green, Sally C Morton, Brian J Doyle, Kanaka Shetty, Aziza Arifkhanova, Marika Booth, Roberta Shanman, Paul Shekelle
OBJECTIVE: Quality improvement (QI) interventions can improve glycemic control, but little is known about their value. We systematically reviewed economic evaluations of QI interventions for glycemic control among adults with type 1 or type 2 diabetes. RESEARCH DESIGN AND METHODS: We used English-language studies from high-income countries that evaluated organizational changes and reported program and utilization-related costs, chosen from PubMed, EconLit, Centre for Reviews and Dissemination, New York Academy of Medicine's Grey Literature Report, and WorldCat (January 2004 to August 2016)...
May 2018: Diabetes Care
https://www.readbyqxmd.com/read/29678801/stigma-and-its-association-with-glycemic-control-and-hypoglycemia-in-adolescents-and-young-adults-with-type-1-diabetes-cross-sectional-study
#7
Anne-Sophie Brazeau, Meranda Nakhla, Michael Wright, Mélanie Henderson, Constadina Panagiotopoulos, Daniele Pacaud, Patricia Kearns, Elham Rahme, Deborah Da Costa, Kaberi Dasgupta
BACKGROUND: Qualitative studies in type 1 diabetes indicate that visibility of diabetes supplies, self-care, and hypoglycemia symptoms are associated with stigma and suboptimal management. This may be particularly salient in youth who face concurrent challenges such as establishing autonomy and making vocational choices. OBJECTIVE: The aim of the study was to estimate stigma prevalence in youth (aged 14-24 years) with type 1 diabetes and its associations with glycemic control...
April 20, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29677253/in-type-2-diabetes-weekly-semaglutide-reduced-hba1c-and-increased-weight-loss-more-than-weekly-exenatide-er
#8
Eleni Bekiari, Thomas Karagiannis, Apostolos Tsapas
No abstract text is available yet for this article.
April 17, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29676968/effects-of-daily-intake-of-calcium-and-vitamin-d-enriched-milk-in-healthy-postmenopausal-women-a-randomized-controlled-double-blind-nutritional-study
#9
Rebeca Reyes-Garcia, Nicolas Mendoza, Santiago Palacios, Nancy Salas, Miguel Quesada-Charneco, Antonia Garcia-Martin, Juristo Fonolla, Federico Lara-Villoslada, Manuel Muñoz-Torres
OBJECTIVE: To determine the effect of the daily intake of calcium and vitamin D-enriched milk (with or without fructooligosaccharides [FOS]) on vitamin D, bone metabolism, and cardiovascular risk factors. MATERIALS AND METHODS: Two-year randomized controlled study, including 500 healthy postmenopausal women, assigned to 500 mL/day of skimmed milk to one of three groups: Low-dose (L): (120 mg/100 mL calcium, vitamin D3 30 UI/100 mL), group A: calcium and vitamin D (180 mg/100 mL and 120 UI/100 mL), and group B: calcium and vitamin D (180 mg/100 mL and 120 UI/100 mL) and FOS (5 g/L)...
April 20, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29676875/-faster-aspart-insulin-fiasp%C3%A2
#10
N Paquot, A J Scheen
Fast-acting insulin aspart (faster aspart), commercialized under the trade name of Fiasp®, is insulin aspart in a new formulation aiming to mimic the physiologic prandial insulin release more closely than currently available rapid-acting insulin products. Fiasp® is insulin aspart (NovoRapid®) in which two excipients (L-arginine and niacinamide) have been added, L-arginine serving as a stabilising agent, while niacinamide being responsible for accelerated initial absorption after subcutaneous administration...
April 2018: Revue Médicale de Liège
https://www.readbyqxmd.com/read/29676589/association-of-diabetes-diagnosis-with-dietary-changes-and-weight-reduction
#11
Daeho Kim, Kanghyock Koh, Shailender Swaminathan, Amal N Trivedi
BACKGROUND: Lifestyle modifications are associated with better outcomes for patients with diabetes. Patients' awareness of having diabetes may promote lifestyle changes, but there is limited evidence to support this assertion. This study examined whether a report of physician-diagnosed diabetes is associated with dietary changes and efforts to lose weight. METHODS: Cross-sectional comparison of individuals with and without diabetes or prediabetes diagnosis, matched on glycosylated hemoglobin (HbA1c) level, socio-demographic characteristics, and health status using propensity-score matching analysis...
April 20, 2018: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/29676544/clinical-implications-of-using-post-challenge-plasma-glucose-levels-for-early-diagnosis-of-type-2-diabetes-mellitus-in-older-individuals
#12
Kyong Hye Joung, Sang Hyun Ju, Ji Min Kim, Sorim Choung, Jae Min Lee, Kang Seo Park, Hyun Jin Kim, Bon Jeong Ku
BACKGROUND: The aim of this study was to explore the differences in the clinical characteristics and diagnostic rates of diabetes mellitus (DM) according to various criteria in different age groups and to evaluate the efficacy of each criterion for screening older patients. METHODS: We studied 515 patients and measured the fasting plasma glucose level (FPG), 2-hour plasma glucose level after the 75 g oral glucose tolerance test (2-hour postload glucose [2-h PG]), and glycosylated hemoglobin (HbA1c) for re-evaluation of hyperglycemia without a history of diabetes...
April 2018: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/29675980/longitudinal-assessment-of-hippocampus-structure-in-children-with-type-1-diabetes
#13
Lara C Foland-Ross, Allan L Reiss, Paul K Mazaika, Nelly Mauras, Stuart A Weinzimer, Tandy Aye, Michael J Tansey, Neil H White
The extant literature finds that children with type 1 diabetes (T1D) experience mild cognitive alterations compared to healthy age-matched controls. The neural basis of these cognitive differences is unclear but may relate in part to the effects of dysglycemia on the developing brain. We investigated longitudinal changes in hippocampus volume in young children with early-onset T1D. Structural magnetic resonance imaging data were acquired from 142 children with T1D and 65 age-matched control subjects (4-10 years of age at study entry) at two time points, 18 months apart...
April 19, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29675798/a-systematic-literature-review-and-network-meta-analysis-comparing-once-weekly-semaglutide-with-other-glp-1-receptor-agonists-in-patients-with-type-2-diabetes-previously-receiving-1-2-oral-anti-diabetic-drugs
#14
Michal Witkowski, Lars Wilkinson, Neil Webb, Alan Weids, Divina Glah, Hrvoje Vrazic
INTRODUCTION: Once-weekly semaglutide is a new glucagon-like peptide-1 (GLP-1) analogue administered at a 1.0 or 0.5 mg dose. As head-to-head trials assessing once-weekly semaglutide as an add-on to 1-2 oral anti-diabetic drugs (OADs) vs other GLP-1 receptor agonists (GLP-1 RAs) are limited, a network meta-analysis (NMA) was performed. The objective was to assess the relative efficacy and safety of once-weekly semaglutide vs GLP-1 RAs in patients with type 2 diabetes (T2D) inadequately controlled on 1-2 OADs...
April 19, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29675797/treatment-intensification-in-type-2-diabetes-a-real-world-study-of-2-oad-regimens-glp-1-ras-or-basal-insulin
#15
Lawrence Blonde, Denis Raccah, Elisheva Lew, Juliana Meyers, Elena Nikonova, Mayank Ajmera, Keith L Davis, Monica Bertolini, Bruno Guerci
INTRODUCTION: Treatment guidelines recommend a stepwise approach to glycemia management in patients with type 2 diabetes (T2D), but this may result in uncontrolled glycated hemoglobin A1c (HbA1c) between steps. This retrospective analysis compared clinical and economic outcomes among patients with uncontrolled T2D initiating two oral antidiabetes drugs (OADs), glucagon-like peptide-1 receptor agonists (GLP-1 RAs), or basal insulin in a real-world setting. METHODS: Adults with T2D on OAD monotherapy were identified in the MarketScan claims database (2007-2014)...
April 19, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29675559/truncated-aptamers-for-total-and-glycated-hemoglobin-and-their-integration-into-a-graphene-oxide-based-fluorometric-method-for-high-throughput-screening-for-diabetes
#16
Abrar Yousef Almusharraf, Shimaa Eissa, Mohammed Zourob
The authors describe the identification of an effective binding region of aptamers against glycated (HbA1c) and total haemoglobin (tHb) by using a fluorometric assay. Truncation of the originally selected aptamers from 60 to 46 and 34 nucleotides for HbA1c and tHb, respectively, enhances the affinity for their targets. Moreover, shortening the aptamer sequences leads to a better conformational change after target binding which enabled the integration of the aptamers in a graphene oxide (GO)-based fluorometric assay...
April 19, 2018: Mikrochimica Acta
https://www.readbyqxmd.com/read/29674706/discordance-in-glycemic-categories-and-regression-to-normality-at-baseline-in-10-000-people-in-a-type-2-diabetes-prevention-trial
#17
Mike Sampson, Tim Elwell-Sutton, Max O Bachmann, Allan Clark, Ketan K Dhatariya, Clare Ferns, Amanda Howe, W Garry John, Gerry Rayman, Leyla Swafe, Jeremy Turner, Melanie Pascale
The world diabetes population quadrupled between 1980 and 2014 to 422 million and the enormous impact of Type 2 diabetes is recognised by the recent creation of national Type 2 diabetes prevention programmes. There is uncertainty about how to correctly risk stratify people for entry into prevention programmes, how combinations of multiple 'at high risk' glycemic categories predict outcome, and how the large recently defined 'at risk' population based on an elevated glycosylated haemoglobin (HbA1c) should be managed...
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29674332/potent-sglt1-2-dual-inhibition-improves-glycemic-control-without-marked-gastrointestinal-adaptation-or-colonic-microbiota-changes-in-rodents
#18
Fuyong Du, Simon Hinke, Cassandre Cavanaugh, David Polidori, Nathanial Wallace, Thomas Kirchner, Matthew Jennis, Wensheng Lang, Gee-Hong Kuo, Micheal Gaul, James Lenhard, Keith Demarest, Nadim J Ajami, Yin Liang, Pamela J Hornby
The sodium/glucose cotransporters (SGLT1 and SGLT2) transport glucose across the intestinal brush border and kidney tubule. Dual SGLT1/2 inhibition could reduce hyperglycemia more than SGLT2-selective in patients with Type 2 Diabetes; however, questions remain about altered gastrointestinal (GI) luminal glucose and tolerability. Therefore, this was evaluated in slc5a1-/- mice or using a potent dual inhibitor (cmpd 8; SGLT1 Ki = 1.5±0.5nM 100 fold > potency than phlorizin; SGLT2 Ki = 0.4±0.2 nM). 13C6-glucose uptake was quantified in slc5a1 -/- mice and in isolated rat jejunum...
April 19, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29674323/hemoglobin-a-1c-accurately-predicts-continuous-glucose-monitoring-derived-average-glucose-in-youth-and-young-adults-with-cystic-fibrosis
#19
Christine L Chan, Emma Hope, Jessica Thurston, Timothy Vigers, Laura Pyle, Philip S Zeitler, Kristen J Nadeau
OBJECTIVE: In cystic fibrosis (CF), HbA1c is thought to underestimate glycemia. However, few studies have directly assessed the relationship between HbA1c and average glucose in CF. We determined the relationships among glycemic markers-HbA1c , fructosamine (FA), glycated albumin (%GA), and 1,5-anhydroglucitol (1,5-AG)-and continuous glucose monitoring (CGM) in CF, hypothesizing that alternate markers would better predict average sensor glucose (ASG) than HbA1c . RESEARCH DESIGN AND METHODS: CF participants and a group of healthy control subjects (HC), ages 6-25 years, wore CGM for up to 7 days...
April 19, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29674135/mean-hba-1c-hba-1c-variability-and-mortality-in-people-with-diabetes-aged-70-years-and-older-a-retrospective-cohort-study
#20
Angus Forbes, Trevor Murrells, Henrietta Mulnier, Alan J Sinclair
BACKGROUND: Glycaemic targets for older people have been revised in recent years because of concern that more stringent targets are associated with increased mortality. We aimed to investigate the association between glycaemic control (mean HbA1c ) and variability (variability of HbA1c over time) and mortality in older people with diabetes. METHODS: We did a 5-year retrospective cohort study using The Health Improvement Network database, which includes data from 587 UK primary care practices...
April 16, 2018: Lancet Diabetes & Endocrinology
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