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https://www.readbyqxmd.com/read/28527305/changes-in-hba1c-and-hypoglycemic-episodes-in-type-1-diabetes-patients-after-switching-to-insulin-glargine-u300-pilot-study
#1
Marina Gradišer, Maja Cigrovski Berković, Ines Bilić-Ćurčić
We included diabetes type 1 (T1DM) patients with suboptimal glycemic control on morning application glargine (I-Glar) U100, switching them to U300. After six months improvement in HbA1c was observed, while hypoglycemic episodes decreased. Switch from I-Glar U100 to U300 could be a good therapeutic option for that subset of patients.
May 9, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28526920/effects-of-semaglutide-on-beta-cell-function-and-glycaemic-control-in-participants-with-type-2-diabetes-a-randomised-double-blind-placebo-controlled-trial
#2
Christoph Kapitza, Kirsten Dahl, Jacob B Jacobsen, Mads B Axelsen, Anne Flint
AIMS/HYPOTHESIS: Semaglutide is a glucagon-like peptide-1 analogue in development for the treatment of type 2 diabetes. Its effects on first- and second-phase insulin secretion and other measures of beta cell function and glycaemic control were assessed. METHODS: In this single-centre, double-blind, placebo-controlled, parallel-group trial, conducted at the Profil Institut für Stoffwechselforschung, Germany, 75 adult (aged 18-64 years) participants with type 2 diabetes (eligibility: HbA1c of 6...
May 19, 2017: Diabetologia
https://www.readbyqxmd.com/read/28526556/circulating-levels-of-cortistatin-are-correlated-with-metabolic-parameters-in-patients-with-newly-diagnosed-type-2-diabetes-mellitus
#3
Wenjia Chen, Yu Fu, Xinhua Yin, Yue Liu
Cortistatin (CST) is a recently discovered cyclic neuropeptide with multiple bioactive effects. The aim of this study was to investigate the relationship between plasma CST and various metabolic markers in patients with newly diagnosed type 2 diabetes mellitus (T2DM). For this study, 60 patients with newly diagnosed T2DM and 38 age- and gender-matched healthy controls were recruited. Fasting plasma glucose (FPG), serum insulin and hemoglobin A1c (HbA1c) levels and a blood lipid profile were obtained with commercially available diagnostic reagents...
May 16, 2017: Peptides
https://www.readbyqxmd.com/read/28526011/risk-of-acute-kidney-injury-and-survival-in-patients-treated-with-metformin-an-observational-cohort-study
#4
Samira Bell, Bassam Farran, Stuart McGurnaghan, Rory J McCrimmon, Graham P Leese, John R Petrie, Paul McKeigue, Naveed Sattar, Sarah Wild, John McKnight, Robert Lindsay, Helen M Colhoun, Helen Looker
BACKGROUND: Whether metformin precipitates lactic acidosis in patients with chronic kidney disease (CKD) remains under debate. We examined whether metformin use was associated with an increased risk of acute kidney injury (AKI) as a proxy for lactic acidosis and whether survival among those with AKI varied by metformin exposure. METHODS: All individuals with type 2 diabetes and available prescribing data between 2004 and 2013 in Tayside, Scotland were included. The electronic health record for diabetes which includes issued prescriptions was linked to laboratory biochemistry, hospital admission, death register and Scottish Renal Registry data...
May 19, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28525822/the-interplay-between-diabetes-depression-and-affective-temperaments-a-structural-equation-model
#5
Martino Belvederi Murri, Sara Mamberto, Lucia Briatore, Chiara Mazzucchelli, Mario Amore, Renzo Cordera
BACKGROUND: Diabetes and depression are reciprocally linked, but few studies modeled their interplay considering the influence of affective temperaments (AT) and demographic factors. METHODS: Participants with type 1 and type 2 diabetes (T1DM and T2DM, n=279) recruited from Diabetes Units were assessed with the Beck Depression Inventory (BDI), Temperament Evaluation of Memphis, Pisa, Paris and San Diego-autoquestionnaire version (TEMPS-A), Morisky Medication Adherence Scale (MMAS), Diabetes Distress Scale (DDS) and Cumulative Illness Rating Scales (CIRS)...
May 11, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28525364/ogtt-1h-serum-c-peptide-to-plasma-glucose-concentration-ratio-is-more-related-to-beta-cell-function-and-diabetes-mellitus
#6
Hongmei Zhang, Bingxian Bian, Fan Hu, Qing Su
Objective To clarify the association between C-peptide index and pancreatic beta cell function and diabetes.Materials and methods We carried out a retrospective analysis of 1021 patients aged 27 to 80 without diabetes from January 2012 to January 2016. All subjects underwent a 75-g oral glucose tolerance test. Blood samples were drawn at 0, 30, 60, 120 and 180 min after the glucose load. Plasma glucose concentrations, serum insulin levels, C-peptide levels, hemoglobin A1c (HbA1c), and other biochemical indicators were determined...
February 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28524766/psychological-flexibility-among-youth-with-type-1-diabetes-relating-patterns-of-acceptance-adherence-and-stress-to-adaptation
#7
Rebecca C Kamody, Kristoffer S Berlin, Tiffany M Rybak, Kimberly L Klages, Gabrielle G Banks, Jeanelle S Ali, Ramin Alemzadeh, Robert J Ferry, Alicia M Diaz Thomas
Psychological flexibility, a complex concept encompassing both acceptance and action related factors, has been identified as a target for intervention for diabetes management. Research suggests acceptance, self-management, and stress, all factors that influence psychological flexibility, have an impact on adaptation to type 1 diabetes (T1D) by youth independently. However, yet to be explored is individually varying patterns of these variables and how they may relate to diabetes adaptation outcomes. The present study aimed to establish individual variations of patterns of these factors to derive profiles of psychological flexibility, and examine their relations to the adaptation outcomes of glycemic control and health-related quality of life...
May 19, 2017: Behavioral Medicine
https://www.readbyqxmd.com/read/28523527/impact-of-estimated-glomerular-filtration-rate-on-diabetic-macular-edema
#8
Shreyas Temkar, Nishanthini Karuppaiah, Brijesh Takkar, Dipankar Bhowmik, Manjari Tripathi, Sivasubramanian Ramakrishnan, Yog Raj Sharma, Rajpal Vohra, Rohan Chawla, Pradeep Venkatesh
PURPOSE: Diabetic macular edema (DME) is a major cause of visual impairment in patients with diabetes and is influenced by various systemic factors. This study evaluates the effect of renal status on DME using estimated glomerular filtration rate (eGFR) as a study marker. METHODS: This was a prospective observational cross-sectional study. One hundred and ninety-five patients of diabetic retinopathy (DR) were included. Group 1 had patients of DR without DME (n = 100), and group 2 had patients of DR with DME (n = 95)...
May 18, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28523483/modeling-the-long-term-cost-effectiveness-of-ideglira-in-patients-with-type-2-diabetes-who-are-failing-to-meet-glycemic-targets-on-basal-insulin-alone-in-the-netherlands
#9
Barnaby Hunt, Divina Glah, Maarten van der Vliet
INTRODUCTION: Insulin degludec/liraglutide (IDegLira) is the first basal insulin and glucagon-like peptide-1 receptor agonist (GLP-1 RA) in a single pen injection device, and a once-daily treatment option for patients with type 2 diabetes mellitus (T2DM) who are uncontrolled on basal insulin and require treatment intensification. The objective of this analysis was to evaluate the long-term cost-effectiveness of IDegLira versus basal-bolus therapy (insulin glargine U100 + 3× daily insulin aspart) for patients with T2DM uncontrolled on basal insulin [HbA1c >53 mmol/mol (>7%)] in the Netherlands...
May 18, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28523482/an-rct-investigating-patient-driven-versus-physician-driven-titration-of-biasp-30-in-patients-with-type-2-diabetes-uncontrolled-using-nph-insulin
#10
Abdelmjid Chraibi, Shoorook Al-Herz, Bich Dao Nguyen, Djoko W Soeatmadji, Anil Shinde, Balasubramanian Lakshmivenkataraman, Samir H Assaad-Khalil
INTRODUCTION: The aim of this study was to confirm the efficacy of patient-driven titration of BIAsp 30 in terms of glycemic control, by comparing it to physician-driven titration of BIAsp 30, in patients with type 2 diabetes in North Africa, the Middle East, and Asia. METHODS: A 20-week, open-label, randomized, two-armed, parallel-group, multicenter study in Egypt, Indonesia, Morocco, Saudi Arabia, and Vietnam. Patients (n = 155) with type 2 diabetes inadequately controlled using neutral protamine Hagedorn (NPH) insulin were randomized to either patient-driven or physician-driven BIAsp 30 titration...
May 18, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28523459/plasma-vascular-endothelial-growth-factor-b-levels-are-increased-in-patients-with-newly-diagnosed-type-2-diabetes-mellitus-and-associated-with-the-first-phase-of-glucose-stimulated-insulin-secretion-function-of-%C3%AE-cell
#11
J Wu, H Wei, H Qu, Z Feng, J Long, Q Ge, H Deng
PURPOSE: To detect plasma vascular endothelial growth factor B (VEGF-B) in individuals with different glucose tolerance and investigate the relationship between plasma VEGF-B levels and the first phase of glucose-stimulated insulin secretion. METHODS: A cross-sectional study was conducted involving 45 patients with newly diagnosed type 2 diabetes mellitus (T2DM), 37 patients with impaired glucose regulation (IGR), and 39 Normal glucose tolerance (NGT) subjects, all of whom underwent intravenous glucose tolerance test...
May 18, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28522762/postmeal-exercise-blunts-postprandial-glucose-excursions-in-people-on-metformin-monotherapy
#12
Melissa Lynn Erickson, Jonathan Peter Little, Jennifer L Gay, Kevin K McCully, Nathan T Jenkins
Metformin is used clinically to reduce fasting glucose with minimal effects on postprandial glucose. Postmeal exercise reduces postprandial glucose and may offer additional glucose-lowering benefit beyond that of metformin alone, yet controversy exists surrounding exercise and metformin interactions. It is currently unknown how postmeal exercise and metformin monotherapy in combination will affect postprandial glucose. Thus, we examined the independent and combined effects of postmeal exercise and metformin monotherapy on postprandial glucose...
May 18, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28521522/effect-of-hb-shuangfeng-on-hba1c-results
#13
Yan Wang, Ping Zhang, Hongxing Zhou, Yingxin Sun, Peng Jiang
No abstract text is available yet for this article.
May 19, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28519964/association-between-serum-25-hydroxyvitamin-d-and-glycated-hemoglobin-levels-in-type-2-diabetes-patients-with-chronic-kidney-disease
#14
Lee Ling Lim, Yong Muh Ng, Pei San Kang, Soo Kun Lim
AIMS/INTRODUCTION: Vitamin D is suggested to influence glucose homeostasis. An inverse relationship between serum 25-hydroxyvitamin D [25(OH)D] and glycemic control in non-chronic kidney disease (CKD) patients with type 2 diabetes (T2D) was reported. We aimed to examine this association among T2D patients with CKD. MATERIALS AND METHODS: 100 T2D participants with stage 3-4 CKD were recruited. Blood for HbA1c , serum 25(OH)D, renal, and lipid profiles were drawn at enrolment...
May 18, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28516377/the-influence-of-sitagliptin-on-treatment-related-quality-of-life-in-patients-with-type-2-diabetes-mellitus-receiving-insulin-treatment-a-prespecified-sub-analysis
#15
Tomoya Mita, Naoto Katakami, Toshihiko Shiraiwa, Hidenori Yoshii, Masahiko Gosho, Hitoshi Ishii, Iichiro Shimomura, Hirotaka Watada
INTRODUCTION: Treatment-related quality of life (QOL) is an important aspect of diabetes management. Here, we investigated the influence of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on treatment-related QOL in patients with type 2 diabetes mellitus treated with insulin. METHODS: This was a prespecified sub-analysis of the Sitagliptin Preventive Study of Intima-Media Thickness Evaluation (SPIKE). The study population consisted of 71 subjects in the sitagliptin group, and 62 subjects in the conventional group who were treated with insulin...
May 17, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28515044/exploring-the-causal-pathway-from-telomere-length-to-coronary-heart-disease-a-network-mendelian-randomization-study
#16
Yiqiang Zhan, Ida K Karlsson, Robert Karlsson, Annika Tillander, Chandra A Reynolds, Nancy L Pedersen, Sara Hägg
Rationale: Observational studies have found shorter leukocyte telomere length to be a risk factor for coronary heart disease (CHD), and more recently the association was suggested to be causal. However, the relationship between telomere length and common metabolic risk factors for CHD is not well understood. Whether these risk factors could explain pathways from telomere length to CHD warrants further attention. Objective: To examine if metabolic risk factors for CHD mediate the causal pathway from short telomere length to increased risk of CHD using a network Mendelian randomization (MR) design...
May 17, 2017: Circulation Research
https://www.readbyqxmd.com/read/28514820/-diagnostic-approach-to-manifestation-of-type-1-diabetes-mellitus
#17
Hannes Kalscheuer, Hendrik Lehnert
The incidence of type 1 and type 2 diabetes mellitus has been increasing simultaneously. Formerly, these two patients' populations could be differentiated easily, but now, due to the overlapping of both groups, specified diagnostics are necessary. In order to substantiate a suspicion on diabetes, quantifying venous plasma glucose is the gold standard in diagnostics. As a precaution, determination of the HbA1c and OGTT is recommended. It is not necessary to determinate antibodies in every new case of diabetes...
May 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28514308/emotional-exhaustion-induced-latent-autoimmune-diabetes-in-adults-in-a-young-lady-a-care-compliant-case-report
#18
Yin-Ling Chen, Yong-Chao Qiao, Xin-Nan Song, Wei Ling, Hai-Lu Zhao, Xiao-Xi Zhang
RATIONALE: Latent autoimmune diabetes in adults (LADA) refers to an autoimmune disorder characterized with detectable islets antibodies in the early diagnosis and increased autoimmune beta-cell failure progression. Notably, this kind of diabetes seems to be confused with other phenotypic diabetes. PATIENT CONCERNS: A young woman suffered an emotional exhaustion-induced LADA, showing asthenia, polydipsia, polyuria, and visible weight loss. The patient emotionally ended a 14-year romantic relationship, leading to the emotional flooding...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28514130/-measuring-adherence-to-self-care-guidelines-for-patients-with-type-2-diabetes-with-diabetic-ulcers-admitted-to-the-orthopedic-rehabilitation-department-at-tel-hashomer-hospital-during-2012-2013
#19
Sigal Ezra, Itzhak Siev-Ner, Itzhak Zaidise
INTRODUCTION: Diabetic foot is a devastating complication of diabetes and represents the major cause of lower limb amputations in the western world in the 21st century. The World Health Organization predicts a dramatic increase in the number of diabetes patients over the next decade and by the year 2025, their number is expected to increase to 300 million. AIMS: Examine whether training leads to improving performance in the built-in self-care guidelines in patients with type 2 diabetes who were hospitalized with diabetic ulcers in the Orthopedic Rehabilitation Ward in Tel Hashomer between the years 2012-2013...
July 2016: Harefuah
https://www.readbyqxmd.com/read/28513288/growth-arrest-specific-protein-6-gas6-as-a-noninvasive-biomarker-for-early-detection-of-diabetic-nephropathy
#20
Wenni Li, Junlin Wang, Lina Ge, Jiehui Shan, Chunbing Zhang, Jianping Liu
BACKGROUND: To investigate the diagnostic level of cystatin C and growth arrest-specific gene 6 (Gas6) levels in elderly type 2 diabetic patients with different degrees of diabetic nephropathy (DN). METHODS: Four hundred and eighty-two old people, including 130 healthy controls, 130 normoalbuminuric diabetic patients, 122 with microalbuminuria, and 100 with macroalbuminuria, were recruited. Plasma Gas6 and serum cystatin C levels were measured. RESULTS: Plasma Gas6 concentration was significantly lower in diabetic patients with microalbuminuria or macroalbuminuria, as compared with diabetic subjects with normoalbuminuria; while cystatin C was significantly higher...
May 17, 2017: Clinical and Experimental Hypertension: CHE
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