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https://www.readbyqxmd.com/read/29933462/protective-effects-of-an-obesity-associated-polymorphism-cdkal1-rs9356744-on-prediabetes-the-cardiometabolic-risk-in-chinese-crc-study
#1
J Liang, Y Zhu, X-K Liu, Q-Q Qiu, Y-T Sun, Y Wang, Y Pei, M-Q Yang, L Qi
BACKGROUND: Obesity is strongly associated with insulin resistance and elevated plasma glucose levels. The rs9356744 polymorphism in the CDKAL1 gene is associated with body mass index (BMI) only in East Asians. Here, we examined the effect of the rs9356744 polymorphism on glucose-related traits and prediabetes in Chinese adults. METHODS: A total of 2 357 participants were enrolled from the Cardiometabolic Risk in Chinese (CRC) Study, including 499 persons with prediabetes, 204 persons with type 2 diabetes, and 1 654 normoglycemic controls...
June 22, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29933406/anemia-modifies-the-prognostic-value-of-glycated-hemoglobin-in-patients-with-diabetic-chronic-kidney-disease
#2
I-Ching Kuo, Hugo You-Hsien Lin, Sheng-Wen Niu, Jia-Jung Lee, Yi-Wen Chiu, Chi-Chih Hung, Shang-Jyh Hwang, Hung-Chun Chen
A common complication of chronic kidney disease (CKD), anemia can influence glycated hemoglobin (HbA1c) levels. In diabetic patients, anemia occurs earlier and with higher severity over the course of CKD stages. To elucidate the effect of hemoglobin (Hb) on the predictive value of HbA1c, we enrolled 1558 diabetic patients with stages 3-4 CKD, categorized according to baseline Hb and HbA1c quartiles. Linear regression revealed that higher HbA1c correlated significantly with higher Hb in the Hb < 10 g/dL group (β = 0...
2018: PloS One
https://www.readbyqxmd.com/read/29932560/a-multiple-behavior-self-monitoring-intervention-for-african-american-veterans-with-type-2-diabetes-a-feasibility-implementation-study
#3
Ngozi D Mbue, Jing Wang, Stanley G Cron, Jane A Anderson
The purpose of this study was to determine the feasibility of implementing a multiple-behavior self-monitoring intervention within a diabetes education program. This study was a 3-month pre- post-design, conducted with African-Americans (N = 20), who attended diabetes education classes at a large Veteran's Affairs (VA) hospital in Southwest Texas. Participants selfmonitored their blood glucose, diet, exercise, and weight on either a smart phone application or paper diaries. Paired t tests showed strong evidence that patient self-monitoring of healthy lifestyle behaviors improved blood glucose (t = -3...
July 2017: Journal of National Black Nurses' Association: JNBNA
https://www.readbyqxmd.com/read/29931731/variations-in-access-to-and-reimbursement-for-continuous-glucose-monitoring-systems-for-people-living-with-type-1-diabetes-across-england
#4
R Perera, N Oliver, E Wilmot, C Marriott
Since the introduction of real-time continuous glucose monitoring (CGM) systems more than 15 years ago and, more recently, flash glucose monitoring (Flash-GM), clinical studies have observed reductions in HbA1c , independent of insulin delivery method, with decreasing time spent in hypoglycaemia [1] and reduction in glycaemic variability [2]. CGM can improve quality of life and reduce diabetes-related distress [3], including fear of hypoglycaemia [4,5]. Despite these benefits, CGM has yet to be fully implemented as part of the standard of care for people living with Type 1 diabetes in England, and there is considerable variation in how it is funded through local payer organizations...
June 22, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29931457/impact-of-genetic-determinants-of-hba1c-on-type-2-diabetes-risk-and-diagnosis
#5
REVIEW
Chloé Sarnowski, Marie-France Hivert
PURPOSE OF REVIEW: Glycated hemoglobin (A1c) is used to diagnose type 2 diabetes and monitor glycemic control. Specific genetic variants interfere with A1c and effects/frequencies of some variants vary by ancestry. In this review, we summarize findings from large trans-ethnic meta-analyses of genome-wide association studies (GWAS) of A1c and describe some variants influencing erythrocyte biology and interfering with A1c. RECENT FINDINGS: Recent GWAS meta-analyses have revealed 60 loci associated with A1c in multi-ethnic populations...
June 21, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29931423/the-effects-of-probiotics-and-synbiotic-supplementation-on-glucose-and-insulin-metabolism-in-adults-with-prediabetes-a-double-blind-randomized-clinical-trial
#6
Nazila Kassaian, Awat Feizi, Ashraf Aminorroaya, Parvaneh Jafari, Maryam Tajabadi Ebrahimi, Masoud Amini
AIMS: Probiotics and/or prebiotics could be a promising approach to improve metabolic disorders by favorably modifying the gut microbial composition. OBJECTIVES: To assess the effects of probiotics and synbiotic on glycemic indices in prediabetic individuals who are at risk of type 2 diabetes and its complications. METHODS: In a double-blind, randomized, placebo-controlled parallel-group clinical trial, 120 prediabetic adults participated and were randomly allocated to receive either probiotics or synbiotic or placebo supplements for 24 weeks...
June 22, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29931224/long-term-risk-of-hypertension-in-normoglycemia-and-prediabetes-and-their-relation-to-the-change-of-glycemic-state
#7
Ju Young Jung, Chang-Mo Oh, Joong-Myung Choi, Jae-Hong Ryoo, Sung Keun Park
Background: Although increasing evidence has suggested the significant association between dysglycemia and hypertension, this association is less well described in prediabetes. Additionally, it is unclear how risk of hypertension varies according to the change of glycemic state. Methods: 5,413 non-diabetic Koreans were dichotomized into normoglycemia (NG) and prediabetes group and followed-up for 10 years. Cox proportional hazard model was used to evaluate hazard ratios (HRs) with 95% confidence interval (CI) [adjusted HRs (95% CI)] for the development of hypertension...
June 21, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29930416/-effectiveness-of-self-management-behavior-intervention-on-type-2-diabetes-based-on-self-determination-theory
#8
S L Liu, H Y Na, W H Li, Q P Yun, X W Jiang, J N Liu, C Chang
OBJECTIVE: To provide autonomy support from three dimensions based on self-determination theory (SDT), i.e. professional support, peer support, family support, and to investigate whether this intervention can improve diabetes self-management behavior and glycemic control of diabetic patients, and to analyze the influencing factors of the effect. METHODS: Using convenient sampling method, three communities were selected respectively in Beijing. Each community selected health service stations with similar conditions as different intervention groups...
June 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29929836/sex-differences-in-neuropathic-pain-in-longstanding-diabetes-results-from-the-canadian-study-of-longevity-in-type-1-diabetes
#9
Nancy Cardinez, Leif E Lovblom, Johnny-Wei Bai, Evan Lewis, Alon Abraham, Daniel Scarr, Julie A Lovshin, Yuliya Lytvyn, Genevieve Boulet, Mohammed A Farooqi, Andrej Orszag, Alanna Weisman, Hillary A Keenan, Michael H Brent, Narinder Paul, Vera Bril, David Z Cherney, Bruce A Perkins
AIM: Neuropathy and neuropathic pain are common complications of type 1 diabetes (T1D). We aimed to determine if sex-specific differences in neuropathic pain are present in adults with longstanding T1D. METHODS: Canadians with ≥50 years of T1D (n = 361) completed health history questionnaires that included assessment of neuropathy (defined by Michigan Neuropathy Screening Instrument questionnaire components ≥3; NEUROPATHYMNSI-Q ) and neuropathic pain. Multivariable logistic regression was used to determine sex-differences in neuropathic pain controlling for neuropathy...
May 5, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29929537/aggression-following-traumatic-brain-injury-effectiveness-of-risperidone-after-study-protocol-for-a-feasibility-randomised-controlled-trial
#10
Shoumitro Deb, Verity Leeson, Lina Aimola, Mayur Bodani, Lucia Li, Tim Weaver, David Sharp, Mike Crawford
BACKGROUND: Traumatic brain injury (TBI) is a major public health concern and many people develop long-lasting physical and neuropsychiatric consequences following a TBI. Despite the emphasis on physical rehabilitation, it is the emotional and behavioural consequences that have greater impact on people with TBI and their families. One such problem behaviour is aggression which can be directed towards others, towards property or towards the self. Aggression is reported to be common after TBI (37-71%) and causes major stress for patients and their families...
June 21, 2018: Trials
https://www.readbyqxmd.com/read/29928138/the-influences-of-bariatric-surgery-on-hemoglobin-a1c-in-a-sample-of-obese-patients-in-saudi-arabia
#11
Anwar E Ahmed, Wala R Alanazi, Rayan A Ahmed, Wijdan AlJohi, Doaa A AlBuraikan, Budor A AlRasheed, Bashayr I ALMuqbil, Ali A Al-Zahrani, Zeyad M Yousef, Hamdan Al-Jahdali
Background: Although the frequency of surgical weight loss interventions has increased in Saudi Arabia, literature describing the clinical outcomes of bariatric surgery in Saudi Arabia is limited. This study aimed to assess whether weight loss intervention improves hemoglobin A1c (HbA1c) in obese patients and to identify its associated factors. Patients and methods: A retrospective study was carried out on 318 patients with obesity class 1 or higher (body mass index [BMI] ≥ 30 kg/m2 ) who underwent laparoscopic sleeve gastrectomy or Roux-en-Y gastric bypass at King Abdulaziz Medical City in Riyadh, Saudi Arabia, between January 1, 2001 and March 31, 2017...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/29927053/association-between-walnut-consumption-and-diabetes-risk-in-nhanes
#12
Lenore Arab, Satvinder K Dhaliwal, Carly J Martin, Alena D Larios, Nicholas J Jackson, David Elashoff
BACKGROUND: Dietary interventions and cohort studies relating tree nut consumption to blood glucose levels suggest a possible effect of walnuts. OBJECTIVE: To examine the associations between walnut consumption and diabetes risk using data from the National Health and Nutrition Examination Survey (NHANES). METHODS: NHANES survey data on adults conducting 24 hour dietary recall was pooled across the years 1999 through 2014. Diabetes status or risk was based on self-report, medication use, fasting plasma (FPG) glucose levels and hemoglobin A1c (HbA1c) levels...
June 21, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29926400/ipragliflozin-add-on-therapy-to-a-glp-1-receptor-agonist-in-japanese-patients-with-type-2-diabetes-agate-a-52-week-open-label-study
#13
Hisamitsu Ishihara, Susumu Yamaguchi, Ikko Nakao, Taishi Sakatani
INTRODUCTION: Few data are available regarding ipragliflozin treatment in combination with glucagon-like peptide-1 (GLP-1) receptor agonists. The aim of this study was to evaluate the efficacy and safety of ipragliflozin in combination with GLP-1 receptor agonists in Japanese patients with inadequately controlled type 2 diabetes mellitus (T2DM). METHODS: This multicenter study (consisting of three periods: a 4-week washout period, a 6-week observation period, and a 52-week open-label treatment period) included patients aged ≥ 20 years who received a stable dose/regimen of a GLP-1 receptor agonist either solely or in combination therapy with a sulfonylurea for ≥ 6 weeks, with glycosylated hemoglobin (HbA1c) of ≥ 7...
June 20, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29925523/the-metabolic-outcomes-of-growth-hormone-treatment-in-children-are-gender-specific
#14
Alessandro Ciresi, Stefano Radellini, Valentina Guarnotta, Maria Grazia Mineo, Carla Giordano
OBJECTIVE: To evaluate the impact of gender on the clinical and metabolic parameters in prepubertal GHD children at diagnosis and during GH treatment (GHT). DESIGN: The data of 105 prepubertal children (61 males, 44 females, mean age 6.8 ± 0.7 years) affected by idiopathic GHD were retrospectively evaluated. METHODS: Body height, BMI, waist circumference (WC), IGF-I, HbA1c, lipid profile, fasting and after-OGTT glucose and insulin levels, insulin sensitivity and secretion indices were evaluated at baseline and after 24 months of GHT...
June 20, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29925356/integration-of-care-for-hypertension-and-diabetes-a-scoping-review-assessing-the-evidence-from-systematic-reviews-and-evaluating-reporting
#15
Kristy C Yiu, Anke Rohwer, Taryn Young
BACKGROUND: With the rise in pre-mature mortality rate from non-communicable disease (NCD), there is a need for evidence-based interventions. We evaluated existing systematic reviews on effectiveness of integration of healthcare services, in particular with focus on delivery of care designed to improve health and process outcomes in people with multi-morbidity, where at least one of the conditions was diabetes or hypertension. METHODS: We searched MEDLINE, EMBASE, Cochrane Library, and Health Evidence to November 8, 2016 and consulted experts...
June 20, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29925339/maternal-overweight-is-not-an-independent-risk-factor-for-increased-birth-weight-leptin-and-insulin-in-newborns-of-gestational-diabetic-women-observations-from-the-prospective-each-cohort-study
#16
Raffael Ott, Jens H Stupin, Andrea Loui, Elisabeth Eilers, Kerstin Melchior, Rebecca C Rancourt, Karen Schellong, Thomas Ziska, Joachim W Dudenhausen, Wolfgang Henrich, Andreas Plagemann
BACKGROUND: Both gestational diabetes mellitus (GDM) as well as overweight/obesity during pregnancy are risk factors for detrimental anthropometric and hormonal neonatal outcomes, identified to 'program' adverse health predispositions later on. While overweight/obesity are major determinants of GDM, independent effects on critical birth outcomes remain unclear. Thus, the aim of the present study was to evaluate, in women with GDM, the relative/independent impact of overweight/obesity vs...
June 20, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29924756/xerostomia-thirst-sodium-gradient-and-inter-dialytic-weight-gain-in-hemodialysis-diabetic-vs-non-diabetic-patients
#17
A Bruzda-Zwiech, J Szczepańska, R Zwiech
BACKGROUND: In hemodialysis (HD) patients, xerostomia and hyposalivation may intensify sensations of thirst, and contribute to the intake of fluids and excessive inter-dialytic weight gain (IWG). Since IWG is regarded to be higher in diabetic patients than in non-diabetics HD enhancing their mortality, it is crucial to define plausible underlying causes. Therefore, the study investigates factors contributing to the increased IWG in diabetic HD patients. MATERIAL AND METHODS: The study included 97 HD patients (38 diabetics) receiving hemodialysis...
June 20, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29924641/efficacy-safety-and-acceptability-of-the-new-pen-needle-34g-%C3%A3-3-5-mm-a-cross-over-randomized-non-inferiority-trial-ago-02-study
#18
Giorgia De Berardis, Marco Scardapane, Giuseppe Lucisano, Santina Abbruzzese, Antonio Carlo Bossi, Elisa Cipponeri, Paola D'Angelo, Lucia Fontana, Roberta Lancione, Giuseppe Marelli, Luigi Sciangula, Antonio Nicolucci
OBJECTIVE: Insulin injection aspects, such as fear of injection and pain, directly affect glycemic control, patient adherence, and quality of life. Use of thinner and shorter needles could increase acceptance of injections. Aim of the study is to evaluate the non-inferiority of the new 34Gx3.5 mm needle compared to a 32GX4mm in patients with diabetes treated with insulin. METHODS: This is an open, randomized, two-period cross-over, noninferiority trial. Every treatment period lasted 3 weeks...
June 20, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29923445/provider-related-linkages-between-primary-care-clinics-and-community-based-senior-centers-associated-with-diabetes-related-outcomes
#19
Polly Hitchcock Noël, Chen-Pin Wang, Erin P Finley, Sara E Espinoza, Michael L Parchman, Mary J Bollinger, Helen P Hazuda
The Institute of Medicine (IOM) suggests that linkages between primary care practices and community-based resources can improve health in lower income and minority patients, but examples of these are rare. We conducted a prospective, mixed-methods observational study to identify indicators of primary care-community linkage associated with the frequency of visits to community-based senior centers and improvements in diabetes-related outcomes among 149 new senior center members (72% Hispanic). We used semistructured interviews at baseline and 9-month follow-up, obtaining visit frequency from member software and clinical assessments including hemoglobin A1c (HbA1c) from colocated primary care clinics...
June 1, 2018: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://www.readbyqxmd.com/read/29923361/efficacy-of-iglarlixi-a-fixed-ratio-combination-of-insulin-glargine-and-lixisenatide-in-patients-with-type-2-diabetes-stratified-as-high-and-low-risk-according-to-hedis-measures
#20
Danny H Sugimoto, Terry Dex, William Stager, Vanita R Aroda
The Healthcare Effectiveness Data and Information Set (HEDIS) measures assess glycaemic goal attainment in patients with type 2 diabetes, incorporating factors including age and health status. Healthier patients are assigned a glycated haemoglobin (HbA1c) goal of < 7% (classified as low-risk [LR]); individuals aged > 65 years or with comorbidities are assigned a goal of < 8% (high-risk [HR]). This post-hoc analysis assessed the safety and efficacy of iGlarLixi, a fixed-ratio combination of insulin glargine 100 U/mL (iGlar) and lixisenatide, in 1,898 patients from the phase 3 LixiLan-L and LixiLan-O clinical trials, retrospectively classified as LR (n = 1,181) or HR (n = 717)...
June 19, 2018: Diabetes, Obesity & Metabolism
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