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https://www.readbyqxmd.com/read/29151488/impact-of-coronary-stent-fracture-on-restenotic-neointimal-tissue-characterization-after-drug-eluting-stent-implantation
#1
Yasuhiro Uchida, Satoshi Ichimiya, Hideki Ishii, Hideo Oishi, Toshijiro Aoki, Yusuke Miki, Toshiki Kawamiya, Hitoshi Ichimiya, Junji Watanabe, Masaaki Kanashiro, Shinji Hayano, Susumu Suzuki, Tetsuya Amano, Tatsuaki Matsubara, Toyoaki Murohara
Although drug-eluting stents (DESs) reduce the rates of in-stent restenosis (ISR) and subsequent target lesion revascularization, stent fracture (SF) after DES implantation has become an important concern because of its potential association with restenosis and stent thrombosis. We aimed to assess the pathogenic impact of SF on in-stent restenotic neointimal tissue components after DES implantation. We analyzed 43 consecutive patients (14 with SF and 29 without SF) with ISR requiring revascularization after DES implantation between January 2008 and March 2014...
November 17, 2017: International Heart Journal
https://www.readbyqxmd.com/read/29148244/real-life-experience-with-bioresorbable-polymer-everolimus-eluting-stents-is-this-an-answer-in-search-of-a-question
#2
EDITORIAL
Youssef Rahban, Carey Kimmelstiel
Stent thrombosis and clinically driven restenosis are rare in the era of newer generation DES. The Synergy bioresorbable polymer DES appears to be comparable to other durable polymer and other bioabsorbable polymer DES in terms of safety and efficacy at 1-year post implantation. Further long-term study is needed to determine the specific role of the Synergy stent and other DES with bioabsorbable polymers.
November 15, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29147165/outcomes-of-popliteal-to-distal-bypass-combined-with-femoropopliteal-artery-endovascular-treatment-for-critical-limb-ischemia
#3
Yoshihiko Tsuji, Ikuro Kitano, Koji Sugimoto
Objective: The aim of this study was to evaluate outcomes of combined popliteal-to-distal bypass and endovascular treatment (EVT) for femoropopliteal lesions in patients with critical limb ischemia (CLI). Patients and Methods: We reviewed data of 14 CLI patients who were treated by popliteal-to-distal bypass combined with femoropopliteal EVT. The femoropopliteal lesions included 3 TASC II-A, 8 TASC II-B, and 3TASC II-C but no TASC II-D, and balloon dilatation was performed in 9 cases and a stent was placed in 5 cases...
September 25, 2017: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29142486/vitronectin-and-urokinase-type-plasminogen-activator-gene-expression-levels-are-increased-in-patients-with-coronary-artery-in-stent-restenosis
#4
S M Shafiee, F Noorabad-Ghahroodi, A Amirfarhangi, S R Hosseini-Fard, Z Sharifi, M Najafi
Neointimal hyperplasia is known as a main factor contributing to in-stent restenosis (ISR). Monocytes may play a central role in vessel restenosis process after stent implantation. The aim of this study was to investigate the relationships between the urokinase-type plasminogen activator (PLAU) and vitronectin (Vtn) gene expression levels in peripheral blood mononuclear cell samples isolated from whole blood of 66 patients undergoing coronary artery angiography (22 controls, stenosis < 0.05%; 22 with stent no-restenosis and stenosis < 70%; and 22 with ISR and stenosis > 70%)...
December 2017: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/29141596/effects-of-angiotensin-receptor-blockers-on-neointimal-characteristics-in-angina-patients-requiring-stent-implantation-optical-coherence-tomography-analysis
#5
Jae Young Cho, Soon Jun Hong, Do-Sun Lim
BACKGROUND: Angiotensin receptor blockers (ARBs) are known for its anti-inflammatory and anti-proliferative effects. The aim of the study was to evaluate long-term effects of ARBs on morphologic characteristics of stent restenosis in patients with coronary artery disease requiring stent implantation by optical coherence tomography (OCT). METHODS: Patients with coronary artery disease having history of drug-eluting stent implantation (n = 407) were analyzed on the basis of ARB therapy as the ARB group (n = 162) and the non-ARB group (n = 245)...
November 15, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29137966/clinical-outcomes-of-complex-real-world-diabetic-patients-treated-with-amphilimus-sirolimus-eluting-stents-or-zotarolimus-eluting-stents-a-single-center-registry
#6
Rik Rozemeijer, Daniela Benedetto, Adriaan O Kraaijeveld, Michiel Voskuil, Mèra Stein, Leo Timmers, Saskia Z Rittersma, Pierfrancesco Agostoni, Pieter A Doevendans, Pieter R Stella
OBJECTIVE: To assess clinical outcomes of Amphilimus Sirolimus-Eluting Stents (A-SES) as compared to Zotarolimus-Eluting Stents (ZES) in complex real-world diabetic patients. BACKGROUND: Patients with diabetes mellitus represent one of the most challenging scenarios with high rates of restenosis and stent thrombosis in the current era of drug-eluting stents. Hence, we assessed the safety of A-SES versus ZES in complex diabetic patients. METHODS: In this observational study, we analyzed all consecutive patients with diabetes mellitus referred to our center from November 2012 to November 2014...
October 26, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29131806/impact-of-guidewire-recrossing-point-into-stent-jailed-side-branch-for-optimal-kissing-balloon-dilatation-corelab-3d-optical-coherence-tomography-analysis
#7
Takayuki Okamura, Ryoji Nagoshi, Tatsuhiro Fujimura, Yoshinobu Murasato, Masahiro Yamawaki, Shiro Ono, Takeshi Serikawa, Yutaka Hikichi, Hiroaki Norita, Fumiaki Nakao, Tomohiro Sakamoto, Toshiro Shinke, Junya Shite
AIMS: We investigated the influence of the guidewire recrossing point on the incidence of incomplete stent apposition (ISA) after kissing balloon dilatation (KBD), and clinical and angiographic outcome at 9 months in a prospective multicenter registry. METHODS AND RESULTS: One hundred five patients underwent single crossover stenting across the side branch (SB) and subsequent KBD. Jailing configuration of the SB orifice and the guidewire recrossing position were assessed by off-line 3D-OCT in the corelab...
November 14, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29131504/balloon-pin-hole-rupture-during-percutaneous-coronary-intervention-for-recurrent-calcified-in-stent-restenosis-a-case-report
#8
Nobuhiro Murata, Tadateru Takayama, Takafumi Hiro, Atsushi Hirayama
Percutaneous coronary intervention (PCI) for patients with in-stent restenosis (ISR) is generally considered safe and effective. However, due to increased tissue hardness, PCI for calcified intra-stent ISR is technically challenging. Here, we report severe angioplasty-related complications in a patient presenting with calcified, recurrent ISR following PCI. After receiving drug-coated balloon (DCB) angioplasty for an initial ISR, the patient developed recurrent ISR during the follow-up period. Intravascular imaging revealed intra-stent calcifications and balloon angioplasty was subsequently performed...
November 13, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29131001/atorvastatin-calcium-inhibits-pdgf-%C3%AE-%C3%AE-induced-proliferation-and-migration-of-vsmcs-through-the-g0-g1-cell-cycle-arrest-and-suppression-of-activated-pdgfr%C3%AE-pi3k-akt-signaling-cascade
#9
Shuang Chen, Siyuan Dong, Zhao Li, Xiaofan Guo, Naijin Zhang, Bo Yu, Yingxian Sun
BACKGROUND/AIMS: Abnormal proliferation of vascular smooth muscle cells (VSMCs) is a hallmark of vascular lesions, such as atherosclerosis and restenosis. PDGF-ββ, an isoform of PDGF (platelet-derived growth factor), has been demonstrated to induce proliferation and migration of VSMCs. Atorvastatin calcium, a selective inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, has favorable protective effects on VSMCs. This study examined the effects of atorvastatin calcium on the proliferation and migration of PDGF-ββ-treated VSMCs, as well as its underlying mechanisms...
November 9, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29125264/drug-coated-balloons-reduce-the-risk-of-recurrent-restenosis-in-arteriovenous-fistulas-and-prosthetic-grafts-for-hemodialysis
#10
Nicola Troisi, Pierfrancesco Frosini, Chiara Somma, Eugenio Romano, Azzurra Guidotti, Pietro C Dattolo, Giuseppe Ferro, Emiliano Chisci, Stefano Michelagnoli
BACKGROUND: Aim of this study was to evaluate the early and mid-term outcomes of drug-coated balloons (DCBs) in hemodialysis patients with recurrent stenosis of arteriovenous fistula and previously treated with plain balloon angioplasty (PBA). METHODS: Between July 2013 and June 2016 38 hemodialysis patients with recurrent stenosis of arteriovenous fistula underwent endovascular treatment with a DCB at our center. All patients were previously treated at the target lesion with a PBA...
November 10, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/29124384/diagnostic-performance-of-computed-tomography-angiography-in-the-detection-of-coronary-artery-in-stent-restenosis-evidence-from-an-updated-meta-analysis
#11
Tao Dai, Jiang-Rong Wang, Peng-Fei Hu
OBJECTIVES: To evaluate the performance of computed tomography angiography (CTA) ≥64 slices for detecting coronary in-stent restenosis (ISR) and determine the influence of separate characteristics on diagnostic accuracy. METHODS: We searched the PubMed, EMBASE and Cochrane databases for studies of CTA ≥64 slices in diagnosing ISR. We pooled data on bivariate modelling, and subgroup analysis was also performed. RESULTS: A total of 35 studies involving 4131 stents were included...
November 9, 2017: European Radiology
https://www.readbyqxmd.com/read/29122816/local-hemodynamic-forces-after-stenting-implications-on-restenosis-and-thrombosis
#12
REVIEW
Jaryl Ng, Christos V Bourantas, Ryo Torii, Hui Ying Ang, Erhan Tenekecioglu, Patrick W Serruys, Nicolas Foin
Local hemodynamic forces are well-known to modulate atherosclerotic evolution, which remains one of the largest cause of death worldwide. Percutaneous coronary interventions with stent implantation restores blood flow to the downstream myocardium and is only limited by stent failure caused by restenosis, stent thrombosis, or neoatherosclerosis. Cumulative evidence has shown that local hemodynamic forces affect restenosis and the platelet activation process, modulating the pathophysiological mechanisms that lead to stent failure...
November 9, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29122129/a-new-algorithm-for-crossing-chronic-total-occlusions-from-the-asia-pacific-chronic-total-occlusion-club
#13
REVIEW
Scott A Harding, Eugene B Wu, Sidney Lo, Soo Teik Lim, Lei Ge, Ji-Yan Chen, Jie Quan, Seung-Whan Lee, Hsien-Li Kao, Etsuo Tsuchikane
Although the hybrid chronic total occlusion (CTO) algorithm had many excellent recommendations, there has been infrequent adoption in the Asia Pacific region. The Asia Pacific CTO club propose an algorithm for case selection based on the Japan-CTO score and a new CTO algorithm, which is applicable globally. This algorithm allows for differing skill sets and equipment availability and contains practical teaching for CTO percutaneous coronary intervention. Similar to the hybrid algorithm there are 3 main questions that determine whether the primary approach is antegrade or retrograde: 1) is there proximal cap ambiguity; 2) is the distal vessel of poor quality; and 3) are there interventional collaterals present...
November 13, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29121693/short-term-results-of-eluvia%C3%A2-paclitaxel-eluting-stent-in-external-iliac-and-femoropopliteal-lesions
#14
Maxime Elens, Robert Verhelst, Julien Possoz, Stefano Mastrobuoni, Valerie Lacroix, Parla Astarci
INTRODUCTION: The aim of this study was to independently evaluate the real-world performances of Eluvia™ paclitaxel drug-eluting stents (DES) (Boston Scientific, Marlborough, Massachusetts) for the treatment of external iliac and femoropopliteal artery lesions. MATERIALS AND METHODS: We prospectively collected, and retrospectively reviewed, data for all patients who underwent an endovascular treatment with an Eluvia™ DES for the treatment of an external iliac or femoropopliteal lesion...
November 9, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29121226/optical-frequency-domain-imaging-vs-intravascular-ultrasound-in-percutaneous-coronary-intervention-opinion-trial-one-year-angiographic-and-clinical-results
#15
Takashi Kubo, Toshiro Shinke, Takayuki Okamura, Kiyoshi Hibi, Gaku Nakazawa, Yoshihiro Morino, Junya Shite, Tetsuya Fusazaki, Hiromasa Otake, Ken Kozuma, Tetsuya Ioji, Hideaki Kaneda, Takeshi Serikawa, Toru Kataoka, Hisayuki Okada, Takashi Akasaka
Aims: Optical frequency domain imaging (OFDI) is a recently developed, light-based, high-resolution intravascular imaging technique. Intravascular ultrasound (IVUS) is a widely used, conventional imaging technique for guiding percutaneous coronary intervention (PCI). We aimed to demonstrate the non-inferiority of OFDI-guided PCI compared with IVUS-guided PCI in terms of clinical outcomes. Methods and results: We did a prospective, multicentre, randomized (ratio 1:1), active-controlled, non-inferiority study to compare head-to-head OFDI vs...
November 7, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29119701/management-of-urethral-stricture-high-pressure-balloon-dilation-versus-optical-internal-urethrotomy
#16
Yohei Kumano, Takashi Kawahara, Taku Mochizuki, Daiji Takamoto, Teppei Takeshima, Sinnnosuke Kuroda, Jun-Ichi Teranishi, Kazuhide Makiyama, Yasuhide Miyoshi, Yasushi Yumura, Masahiro Yao, Hiroji Uemura
OBJECTIVE: Urethral stenosis is a disease in which the lumen of the urethra becomes constricted by fibrosis. Such stenoses have been treated by urethral dilation using a bougie and optical internal urethrotomy (OIU). Recently, high-pressure balloon dilation (BD) has been developed as a new treatment method for urethral stenosis. The present study compared the effectiveness of urethral dilation by BD and OIU. METHODS: Twenty-two patients of urethral stenosis were treated at Yokohama City University Medical Center between 2005 and 2015...
November 9, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/29119227/-hyaluronic-acid-gels-for-pressure-regulation-in-glaucoma-treatment
#17
REVIEW
M Thaller, H Böhm, C Lingenfelder, F Geiger
BACKGROUND: The increasing numbers of glaucoma patients and complications occuring during treatment, such as restenosis and hypotony, require new treatment options to prevent blindness in patients. Therefore, the abovementioned problems should be solved to prolong the lifetime of implants and to prevent repeated surgery. OBJECTIVE: Can a novel stent with hyaluronic acid hydrogels (HA gel) as a functional unit be used to regulate pressure in glaucoma therapy in the long term? MATERIAL AND METHODS: Model stents were filled with HA gels and it was investigated if these could regulate the pressure and what the underlying mechanism is...
November 8, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29118997/long-and-short-of-optimal-stent-design
#18
REVIEW
Timothy Watson, Mark W I Webster, John A Ormiston, Peter N Ruygrok, James T Stewart
The ideal stent must fulfil a broad range of technical requirements. Stents must be securely crimped onto the delivery balloon and, in this form, must have a low profile and be sufficiently flexible to facilitate deliverability to the lesion site without distortion or displacement. Following expansion, stents must exert sufficient radial force on the vessel wall to overcome lesion resistance and elastic recoil. To achieve an optimal lumen diameter, the lesion must be uniformly and adequately scaffolded, with minimal tissue prolapse between struts but without compromising side-branch access...
2017: Open Heart
https://www.readbyqxmd.com/read/29117919/guideliner-extension-catheter-facilitated-side-strut-stenting-technique-for-the-treatment-of-right-coronary-artery-ostial-in-stent-restenosis
#19
REVIEW
George Kassimis, Tushar Raina
Percutaneous coronary intervention (PCI) for the treatment of right coronary artery (RCA) ostial in-stent restenosis (ISR) can be challenging. The technical difficulties are compounded by excessive stent protrusion into the aorta, preventing coaxial engagement of the guiding catheter and wiring through the central stent lumen. Through this review, we aim to highlight the practical challenges encountered during the treatment of ostial RCA ISR through PCI and evaluate the various interventional techniques that have been used...
September 22, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29115381/proliferation-of-vascular-smooth-muscle-cells-under-inflammation-is-regulated-by-nf-%C3%AE%C2%BAb-p65-microrna-17-rb-pathway-activation
#20
Dong Yang, Chen Sun, Jing Zhang, Shu Lin, Lin Zhao, Lun Wang, Ruoran Lin, Junyuan Lv, Shijie Xin
Inflammation and excessive proliferation of vascular smooth muscle cells (VSMCs) have key roles in various vascular disorders, including restenosis, atherosclerosis and pulmonary artery hypertension. However, the underlying mechanism remains unclear. The present study investigated the role of nuclear factor-κB (NF-κB) and microRNA (miRNA) in the regulation of VSMC proliferation under inflammatory conditions. It was demonstrated that miR‑17 stimulated the proliferation of VSMCs, enhanced cell cycle G1/S transition, and increased levels of proliferating cell nuclear antigen and E2F1...
October 25, 2017: International Journal of Molecular Medicine
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