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https://www.readbyqxmd.com/read/29028788/efficacy-and-safety-of-pembrolizumab-in-patients-enrolled-in-keynote-030-in-the-united-states-an-expanded-access-program
#1
Tara C Gangadhar, Wen-Jen Hwu, Michael A Postow, Omid Hamid, Adil Daud, Roxana Dronca, Richard Joseph, Steven J O'Day, F S Hodi, Anna C Pavlick, Harriet Kluger, Romina P Oxborough, Aiming Yang, Mihaela Gazdoiu, Debra A Kush, Scot Ebbinghaus, April K S Salama
KEYNOTE-030 (ClinicalTrials.gov ID, NCT02083484) was a global expanded access program that allowed access to pembrolizumab, an antiprogrammed death 1 antibody, for patients with advanced melanoma before its regulatory approval. Patients with unresectable stage III/IV melanoma that progressed after standard-of-care therapy, including ipilimumab and, if BRAF mutant, a BRAF inhibitor, were eligible to receive pembrolizumab 2 mg/kg every 3 weeks. Response was assessed by immune-related response criteria by investigator review...
November 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29028634/establishing-a-successful-transition-care-plan-for-the-adolescent-with-congenital-heart-disease
#2
Christopher Talluto
PURPOSE OF REVIEW: In this review we explore the aspects needed to develop a successful transition program for adolescents with congenital heart disease and the barriers that exist to the development of such a program. RECENT FINDINGS: We review the literature including more recent publications which support the development of a transition program in order to facilitate transfer from the pediatric to the adult healthcare system. SUMMARY: With the development of a successful transition program patients will hopefully receive high-quality, continuous life-long care in the appropriate setting...
October 11, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29028406/loading-of-mass-spectrometry-ion-trap-with-th-ions-by-laser-ablation-for-nuclear-frequency-standard-application
#3
Petr V Borisyuk, Sergey P Derevyashkin, Ksenia Y Khabarova, Nikolay N Kolachevsky, Yury Y Lebedinsky, Sergey S Poteshin, Alexey A Sysoev, Evgeny V Tkalya, Dmitry O Tregubov, Viktor I Troyan, Oleg S Vasiliev, Valery P Yakovlev, Valery I Yudin
We describe an original multisectional quadrupole ion trap aimed to realize nuclear frequency standard based on the unique isomer transition in thorium nucleus. It is shown that the system effectively operates on Th(+), Th(2+) and Th(3+) ions produced by laser ablation of metallic thorium-232 target. Laser intensity used for ablation is about 6 GW/cm(2). Via applying a bias potential to every control voltage including the RF one, we are able not only to manipulate ions within the energy range as wide as 1-500 eV but to specially adjust trap potentials in order to work mainly with ions that belong to energy distribution maximum and therefore to effectively enhance the number of trapped ions...
August 2017: European Journal of Mass Spectrometry
https://www.readbyqxmd.com/read/29028226/large-funding-inflows-limited-local-capacity-and-emerging-disease-control-priorities-a-situational-assessment-of-tuberculosis-control-in-myanmar
#4
Mishal S Khan, Sara Schwanke-Khilji, Joanne Yoong, Zaw Myo Tun, Samantha Watson, Richard James Coker
There are numerous challenges in planning and implementing effective disease control programmes in Myanmar, which is undergoing internal political and economic transformations whilst experiencing massive inflows of external funding. The objective of our study-involving key informant discussions, participant observations and linked literature reviews-was to analyse how tuberculosis (TB) control strategies in Myanmar are influenced by the broader political, economic, epidemiological and health systems context using the Systemic Rapid Assessment conceptual and analytical framework...
October 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29028059/a-series-of-organic-inorganic-hybrid-compounds-formed-by-p2w18o62-6-and-several-types-of-transition-metal-complexes
#5
Ying Lü, Li-Na Xiao, Xiang-Rong Hao, Xiao-Bing Cui, Ji-Qing Xu
Five new organic-inorganic hybrid compounds based on [P2W18O62](6-) (abbreviated as {P2W18}) and several types of transition metal complexes (TMCs) have been synthesized and characterized by IR, UV-Vis, XRD, cyclic voltammetry measurements and single crystal X-ray diffraction analysis. [Cu(phen)2][Cu(phen)(H2O)3][Cu(phen)2(H2O)][P2W18O62]·8H2O (1) (phen = 1,10-phenanthroline) is a {P2W18} bi-supported complex of phen, while [Cu(2,2'-bpy)(H2O)2]2[Cu(2,2'-bpy)2][P2W18O62]·3.5H2O (2) (2,2'-bpy = 2,2'-bipyridine) is a 1-D chain structure formed by {P2W18} and copper complexes of 2,2'-bpy...
October 13, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29027807/annals-express-biochemistry-of-the-menopause
#6
John W Honour
The life of a human female is characterised from teenage years by monthly menstruation which ceases (the menopause) typically between the age of 40 and 60 years. The potential for reproduction declines and ceases as the ovaries become depleted of follicles. A transition period in mid-life, for 2 to 10 years, when menstruation is less regular is called the peri-menopause. The menopause is associated with a significant decline in plasma concentrations of sex hormones, an increase in the concentrations of the gonadotrophins and changes in other hormones such as the inhibins...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29027513/-sharing-patient-information-with-neighbourhood-social-support-teams-a-legal-perspective
#7
V E T Dörenberg
The beginning of 2015 saw the transition of responsibility for social care, youth care and participation of vulnerable groups in the Netherlands from the government to local authorities. A large majority of municipalities chose to work with neighbourhood social support teams. Their main purpose is to offer integrated care to citizens. Integrated care requires information-sharing between organisations and (healthcare) professionals. Are medical practitioners authorized to share patient information with neighbourhood social support teams? Legal analysis shows that a medical practitioner may play one of the following three roles when sharing information with such teams: the role of referrer, the role of expert or the role of informant...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29026523/medical-support-during-an-ironman-70-3-triathlon-race
#8
Hae-Rang Yang, Jinwoo Jeong, Injoo Kim, Ji Eun Kim
BACKGROUND: The Ironman 70.3 race is also called a half Ironman, and consists of 1.9 km of swimming, 90.1 km of cycling, and 21.1 km of running. The authors provide practical insights that may be useful for medical support in future events by summarizing the process and results of on-scene medical care. METHODS: The medical post was established at the transition area between the cycling and running courses, which was close to the finish line, and staffed with the headquarters team comprised of an emergency physician, an EMT, two nurses, and an ambulance with a driver...
2017: F1000Research
https://www.readbyqxmd.com/read/29024460/reducing-readmissions-nurse-driven-interventions-in-the-transition-of-care-from-the-hospital
#9
Mae L Dizon, Cheryl Reinking
BACKGROUND: Transitions of care (TOC) from hospitals is a continuing focus for quality improvement to reduce readmissions. Sufficient resources to offer interventions remain an issue for hospitals, leading to efforts to target high-risk patients and identify effective interventions. OBJECTIVES: Describe and measure effects, hospital-wide and among high-risk patients, of a multifaceted TOC program on 30-day readmissions in a 441-bed acute care community hospital...
October 10, 2017: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/29024367/commissioning-guidance-for-weight-assessment-and-management-in-adults-and-children-with-severe-complex-obesity
#10
REVIEW
R Welbourn, J Hopkins, J B Dixon, N Finer, C Hughes, R Viner, J Wass
The challenge of managing the epidemic of patients with severe and complex obesity disease in secondary care is largely unmet. In England, the National Institute of Health and Care Excellence and the National Health Service England have published guidance on the provision of specialist (non-surgical) weight management services. We have undertaken a systematic review of 'what evidence exists for what should happen in/commissioning of: primary or secondary care weight assessment and management clinics in patients needing specialist care for severe and complex obesity?' using an accredited methodology to produce a model for organization of multidisciplinary team clinics that could be developed in every healthcare system, as an update to a previous review...
October 10, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29024333/united-we-stand-divided-we-conquer-pilot-study-of-multidisciplinary-general-medicine-heart-failure-care-program
#11
Omar Wahbi Izzettin, Ingrid Hopper, Edward Ritchie, Vathy Nagalingam, Ar Kar Aung
BACKGROUND: Heart failure care and education require a multifaceted approach to ensure appropriate transition from inpatient to outpatient care. AIMS: To explore the feasibility of a multidisciplinary heart failure care model, General Medicine Heart Failure Care Program (GM-HFCP) within a General Medical Unit (GMU). METHODS: Prospective non-randomised before-and-after observational quality improvement intervention over a 6-month period. All consecutive patients admitted to GMU at Alfred Hospital with diagnosis of acute decompensated heart failure were included...
October 11, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29023914/melanocytic-naevi-with-perineurial-differentiation-a-distinctive-variant-of-neurotised-naevi-and-a-diagnostic-pitfall-with-desmoplastic-melanoma
#12
Ingrid Ferreira, Peter Kind, Ivo Van Den Berghe, Lucy Melly, Felix Offner, Jason L Hornick, Thomas Brenn
AIMS: Spindle cell differentiation is not an uncommon finding in common acquired naevi and may represent a form of neurotisation with Schwannian differentiation of melanocytes. Perineurial differentiation in this context appears to be distinctly rare and is only poorly documented in the literature. METHODS AND RESULTS: We have identified six melanocytic tumours showing spindle cell morphology and perineurial differentiation from routine and referral material. Clinical data and follow-up were obtained, and the histological and immunohistochemical features were analysed...
October 11, 2017: Histopathology
https://www.readbyqxmd.com/read/29022823/impact-of-a-medication-reconciliation-program-on-cardiac-surgery-patients
#13
Abdulrazaq S Al-Jazairi, Lujain Khalid Al-Suhaibani, Rayd A Al-Mehizia, Salma Al-Khani, Glyn Lewis, Edward B De Vol, Elias Juan Saad
Background Cardiac surgery patients are at high risk of medication errors. Resumption of home medications reduces the significance and number of medication errors. This could be achieved by implementing a medication reconciliation program. Patients and Methods Patients were eligible for inclusion in this prospective study if they were admitted, transferred, and/or discharged under cardiac surgery team care from September 2015 to March 2016. The primary outcome was the number and proportion of unintentional medication discrepancies...
January 1, 2017: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/29022035/from-bolam-bolitho-to-modified-montgomery-a-paradigm-shift-in-the-legal-standard-of-determining-medical-negligence-in-singapore
#14
Han Yee Neo
In a recent landmark litigation, the Singapore Court of Appeal introduced a new legal standard for determining medical negligence with regards to information disclosure - the Modified-Montgomery test. This new test fundamentally shifts the legal position concerning the standard of care expected of a doctor when he dispenses medical advice. Previously, a doctor is expected to disclose what a "reasonable physician" would tell his patient. Now, a doctor must disclose "all material risks" that a "reasonable patient" would want to know under his unique circumstances...
September 2017: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/29021380/cost-effectiveness-of-nivolumab-in-recurrent-metastatic-head-and-neck-squamous-cell-carcinoma
#15
Mahdi Zargar, Thomas McFarlane, Kelvin K W Chan, William W L Wong
BACKGROUND: Treatment options for patients with platinum-refractory, recurrent, metastatic head and neck squamous cell carcinoma (r/m HNSCC) are limited and prognosis is poor. The recent CheckMate 141 clinical trial demonstrated that nivolumab, an anti-programmed cell death protein 1 monoclonal antibody, was efficacious in extending the median overall survival (OS) in this patient population compared with standard therapies. We conducted a cost-effectiveness analysis to determine whether nivolumab is a cost-effective treatment in this patient population and examined various subgroups to determine for which, if any, the treatment is more cost-effective...
October 11, 2017: Oncologist
https://www.readbyqxmd.com/read/29021126/healthydads-ca-what-do-men-want-in-a-website-designed-to-promote-emotional-wellness-and-healthy-behaviors-during-the-transition-to-parenthood
#16
Deborah Da Costa, Phyllis Zelkowitz, Nicole Letourneau, Andrew Howlett, Cindy-Lee Dennis, Brian Russell, Steven Grover, Ilka Lowensteyn, Peter Chan, Samir Khalifé
BACKGROUND: Up to 18% of men experience depression and/or anxiety during the transition to parenthood. Interventions designed specifically to promote the mental health of men during the transition to parenthood are scarce. Internet-delivered interventions may be acceptable and far-reaching in enhancing mental health, parenting knowledge, and healthy behaviors in expectant or new fathers. OBJECTIVE: To guide the development of Healthydads.ca, a website designed to enhance mental health and healthy behaviors in expectant fathers, a needs assessment was conducted to identify fathers' perspectives of barriers to seeking help for emotional wellness, informational needs, and factors affecting the decision to visit such a website...
October 11, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29021122/influencing-quality-of-outpatient-sud-care-implementation-of-alerts-and-incentives-in-washington-state
#17
Deborah W Garnick, Constance M Horgan, Andrea Acevedo, Margaret T Lee, Lee Panas, Grant A Ritter, Kevin Campbell, Jason Bean-Mortinson
Financial incentives for quality improvement and feedback on specific clients are two approaches to improving the quality of treatment for individuals with substance use disorders. We examined the impacts of these interventions in Washington State by randomizing outpatient substance use treatment agencies into intervention and control groups. From October 2013 through December 2015, agencies could earn financial incentives for meeting performance goals incorporating both achievement relative to a benchmark and improvement from agencies' own baselines...
November 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29021009/optimizing-the-use-of-discharge-medication-lists-in-nursing-facilities
#18
Andrea C Backes, Patricia Cash, Jessica Jordan
OBJECTIVE: To highlight the need to optimize the use of discharge medication lists in nursing facilities. SETTING: In January 2014, the care transitions (CT) pharmacists at Frederick Memorial Hospital, Frederick, Maryland, began a pilot project in which they identified and followed high-risk patients transitioning from hospital to nursing facility and from nursing facility to home. PRACTICE DESCRIPTION: This pilot project served as a needs assessment to identify opportunities to improve patients' transition from nursing facility to home with the goal of reducing hospital readmissions...
October 1, 2017: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/29021008/medication-review-and-transitions-of-care-a-case-report-of-a-decade-old-medication-error
#19
Rachel Comer, Mitsi Lizer
A 69-year-old Caucasian male with a 25-year history of paranoid schizophrenia was brought to the emergency department because of violence toward the staff in his nursing facility. He was diagnosed with a urinary tract infection and was admitted to the behavioral health unit for medication stabilization. History included a five-year state psychiatric hospital admission and nursing facility placement. Because of poor cognitive function, the patient was unable to corroborate medication history, so the pharmacy student on rotation performed an in-depth chart review...
October 1, 2017: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/29021007/the-senior-care-pharmacist-s-role-in-transitions-of-care
#20
Marylee Grosso, Addolorata M Ciccone
No abstract text is available yet for this article.
October 1, 2017: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
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