Liba Gei, Yan Yan, Wei Xing, Qiang Li, Xiangnan Chen, Fang Yan, Yan Wang, Yan Cao, Wenqi Jiang, E RiQi, DeXing Luo, YanHong Zhang, Weian Zeng, Dongtai Chen
BACKGROUND: The use of morphine in clinical medicine is severely constrained by tolerance. Therefore, it is essential to examine pharmacological therapies that suppress the development of morphine tolerance. Amiloride suppressed the expression of inflammatory cytokines by inhibiting microglial activation. Microglia play a crucial role in the establishment of morphine tolerance. Thus, we anticipated that amiloride might suppress the development of morphine tolerance. During this investigation, we assessed the impact of amiloride on mouse morphine tolerance...
October 31, 2023: European Journal of Pharmacology