keyword
https://read.qxmd.com/read/38175291/acid-sensing-ion-channels-and-downstream-signalling-in-cancer-cells-is-there-a-mechanistic-link
#21
REVIEW
Stefan Gründer, Jakob Vanek, Karolos-Philippos Pissas
It is increasingly appreciated that the acidic microenvironment of a tumour contributes to its evolution and clinical outcomes. However, our understanding of the mechanisms by which tumour cells detect acidosis and the signalling cascades that it induces is still limited. Acid-sensing ion channels (ASICs) are sensitive receptors for protons; therefore, they are also candidates for proton sensors in tumour cells. Although in non-transformed tissue, their expression is mainly restricted to neurons, an increasing number of studies have reported ectopic expression of ASICs not only in brain cancer but also in different carcinomas, such as breast and pancreatic cancer...
January 4, 2024: Pflügers Archiv: European Journal of Physiology
https://read.qxmd.com/read/38158807/transcriptomic-profile-of-the-mechanosensitive-ion-channelome-in-human-cardiac-fibroblasts
#22
JOURNAL ARTICLE
Vadim Mitrokhin, Andrei Bilichenko, Viktor Kazanski, Roman Schobik, Stanislav Shileiko, Veronika Revkova, Vladimir Kalsin, Olga Kamkina, Andre Kamkin, Mitko Mladenov
Human cardiac fibroblasts (HCFs) have mRNA transcripts that encode different mechanosensitive ion channels and channel regulatory proteins whose functions are not known yet. The primary goal of this work was to define the mechanosensitive ion channelome of HCFs. The most common type of cationic channel is the transient receptor potential (TRP) family, which is followed by the TWIK-related K+ channel (TREK), transmembrane protein 63 (TMEM63), and PIEZO channel (PIEZO) families. In the sodium-dependent NON-voltage-gated channel (SCNN) subfamily, only SCNN1D was shown to be highly expressed...
December 30, 2023: Experimental Biology and Medicine
https://read.qxmd.com/read/38139490/multi-channel-gating-chip-in-0-18-%C3%A2%C2%B5m-high-voltage-cmos-for-quantum-applications
#23
JOURNAL ARTICLE
Christoph Ribisch, Michael Hofbauer, Seyed Saman Kohneh Poushi, Alexander Zimmer, Kerstin Schneider-Hornstein, Bernhard Goll, Horst Zimmermann
A gating circuit for a photonic quantum simulator is introduced. The gating circuit uses a large excess bias voltage of up to 9.9 V and an integrated single-photon avalanche diode (SPAD). Nine channels are monolithically implemented in an application-specific integrated circuit (ASIC) including nine SPADs using 0.18 µm high-voltage CMOS technology. The gating circuit achieves rise and fall times of 480 ps and 280 ps, respectively, and a minimum full-width-at-half-maximum pulse width of 1.26 ns. Thanks to a fast and sensitive comparator, a detection threshold for avalanche events of less than 100 mV is possible...
December 6, 2023: Sensors
https://read.qxmd.com/read/38138991/acid-sensing-ion-channels-immunoreactivity-in-nerve-profiles-and-glomus-cells-of-the-human-carotid-body
#24
JOURNAL ARTICLE
Graciela Martínez-Barbero, Yolanda García-Mesa, Ramón Cobo, Patricia Cuendias, Benjamín Martín-Biedma, Olivia García-Suárez, Jorge Feito, Teresa Cobo, José A Vega
The carotid body is a major peripheral chemoreceptor that senses changes in arterial blood oxygen, carbon dioxide, and pH, which is important for the regulation of breathing and cardiovascular function. The mechanisms by which the carotid body senses O2 and CO2 are well known; conversely, the mechanisms by which it senses pH variations are almost unknown. Here, we used immunohistochemistry to investigate how the human carotid body contributes to the detection of acidosis, analyzing whether it expresses acid-sensing ion channels (ASICs) and determining whether these channels are in the chemosensory glomic cells or in the afferent nerves...
December 5, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38137132/acid-sensing-ion-channel-1a-contributes-to-the-prefrontal-cortex-ischemia-enhanced-neuronal-activities-in-the-amygdala
#25
JOURNAL ARTICLE
Gyeongah Park, Qian Ge, Zhen Jin, Jianyang Du
Following a stroke, the emergence of amygdala-related disorders poses a significant challenge, with severe implications for post-stroke mental health, including conditions such as anxiety and depression. These disorders not only hinder post-stroke recovery but also elevate mortality rates. Despite their profound impact, the precise origins of aberrant amygdala function after a stroke remain elusive. As a target of reduced brain pH in ischemia, acid-sensing ion channels (ASICs) have been implicated in synaptic transmission after ischemia, hinting at their potential role in reshaping neural circuits following a stroke...
December 7, 2023: Brain Sciences
https://read.qxmd.com/read/38124816/retracted-a-post-training-quantization-method-for-the-design-of-fixed-point-based-fpga-asic-hardware-accelerators-for-lstm-gru-algorithms
#26
Computational Intelligence And Neuroscience
[This retracts the article DOI: 10.1155/2022/9485933.].
2023: Computational Intelligence and Neuroscience
https://read.qxmd.com/read/38113885/protein-semisynthesis-underscores-the-role-of-a-conserved-lysine-in-activation-and-desensitization-of-acid-sensing-ion-channels
#27
JOURNAL ARTICLE
Debayan Sarkar, Iacopo Galleano, Stephanie Andrea Heusser, Sofie Yuewei Ou, Gül Refika Uzun, Keith K Khoo, Gerbrand Jan van der Heden van Noort, Joseph Scott Harrison, Stephan Alexander Pless
Acid-sensing ion channels (ASICs) are trimeric ion channels that open a cation-conducting pore in response to proton binding. Excessive ASIC activation during prolonged acidosis in conditions such as inflammation and ischemia is linked to pain and stroke. A conserved lysine in the extracellular domain (Lys211 in mASIC1a) is suggested to play a key role in ASIC function. However, the precise contributions are difficult to dissect with conventional mutagenesis, as replacement of Lys211 with naturally occurring amino acids invariably changes multiple physico-chemical parameters...
December 14, 2023: Cell Chemical Biology
https://read.qxmd.com/read/38111840/experimental-demonstration-of-coupled-differential-oscillator-networks-for-versatile-applications
#28
JOURNAL ARTICLE
Manuel Jiménez, Juan Núñez, Jafar Shamsi, Bernabé Linares-Barranco, María J Avedillo
Oscillatory neural networks (ONNs) exhibit a high potential for energy-efficient computing. In ONNs, neurons are implemented with oscillators and synapses with resistive and/or capacitive coupling between pairs of oscillators. Computing is carried out on the basis of the rich, complex, non-linear synchronization dynamics of a system of coupled oscillators. The exploited synchronization phenomena in ONNs are an example of fully parallel collective computing. A fast system's convergence to stable states, which correspond to the desired processed information, enables an energy-efficient solution if small area and low-power oscillators are used, specifically when they are built on the basis of the hysteresis exhibited by phase-transition materials such as VO2 ...
2023: Frontiers in Neuroscience
https://read.qxmd.com/read/38107163/phylogenetic-analysis-provides-insight-into-the-molecular-evolution-of-nociception-and-pain-related-proteins
#29
JOURNAL ARTICLE
Rujun Zhai, Qian Wang
Nociception and pain sensation are important neural processes in humans to avoid injury. Many proteins are involved in nociception and pain sensation in humans; however, the evolution of these proteins in animals is unknown. Here, we chose nociception- and pain-related proteins, including G protein-coupled receptors (GPCRs), ion channels (ICs), and neuropeptides (NPs), which are reportedly associated with nociception and pain in humans, and identified their homologs in various animals by BLAST, phylogenetic analysis and protein architecture comparison to reveal their evolution from protozoans to humans...
2023: Evolutionary Bioinformatics Online
https://read.qxmd.com/read/38104192/a-modular-technique-of-booth-encoding-and-vedic-multiplier-for-low-area-and-high-speed-applications
#30
JOURNAL ARTICLE
C M Kalaiselvi, R S Sabeenian
A technique for efficiently multiplying two signed numbers using limited area and high speed is presented in this paper. This work uses both the Booth and Vedic multiplication sutra methodologies to enhance the speed and reduction in the area by using two VLSI architectures of radix encoding techniques-Radix-4 and Radix-8-with the Vedic multiplier. The functionality of the proposed methods is tested using an Artix-7 Field Programmable Gate Array (FPGA-XC7A100T-CSG324) in Xilinx Vivado 2019.1 and ASIC 45 nm technology...
December 16, 2023: Scientific Reports
https://read.qxmd.com/read/38084765/mesenchymal-stromal-cell-response-to-intervertebral-disc-like-ph-is-tissue-source-dependent
#31
JOURNAL ARTICLE
Kyle Cannon, Sanjitpal Gill, Jeremy Mercuri
Intervertebral disc (IVD) degeneration (IVDD) has become increasingly prevalent and is a common contributing factor to low back pain. Current treatment options are limited to either symptom management or surgery. A promising treatment option being explored is intradiscal administration of mesenchymal stromal cells (MSCs). However, there remains a gap in knowledge as to whether MSCs from different tissue sources have similar responses to the low pH microenvironment of the IVD and the possible mechanisms governing these responses...
December 12, 2023: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/38077663/association-of-the-academic-performance-of-undergraduate-medical-students-with-positive-well-being-intelligence-and-factors-of-academic-success
#32
JOURNAL ARTICLE
Sajida Agha, Abdullah Abdulrahman Alzayed, Tameem Ahmed Alfuraih, Fahad Turki Alenazi, Moath Ibrahim Alomair, Emad Masuadi
BACKGROUND: The academic performance of medical students may affect their competence in future career prospects. Developing students' subjective well-being to improve academic performance is complex and has been investigated for many years. This cross-sectional study assessed the relationship between academic performance, general intelligence, and medical students' positive well-being. METHODS: This cross-sectional, internet-based survey included male and female medical students from pre-clinical and clinical years at one of the largest public-sector universities in Riyadh, Saudi Arabia, between February 2020 and April 2020...
December 2023: Curēus
https://read.qxmd.com/read/38068915/achilles-heel-the-significance-of-maintaining-microenvironmental-homeostasis-in-the-nucleus-pulposus-for-intervertebral-discs
#33
REVIEW
Zhangbin Luo, Ziyan Wei, Guangzhi Zhang, Haiwei Chen, Lei Li, Xuewen Kang
The dysregulation of intracellular and extracellular environments as well as the aberrant expression of ion channels on the cell membrane are intricately linked to a diverse array of degenerative disorders, including intervertebral disc degeneration. This condition is a significant contributor to low back pain, which poses a substantial burden on both personal quality of life and societal economics. Changes in the number and function of ion channels can disrupt the water and ion balance both inside and outside cells, thereby impacting the physiological functions of tissues and organs...
November 22, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38068897/ion-channel-disturbances-in-migraine-headache-exploring-the-potential-role-of-the-kynurenine-system-in-the-context-of-the-trigeminovascular-system
#34
REVIEW
Eleonóra Spekker, Gábor Nagy-Grócz, László Vécsei
Migraine is a primary headache disorder, which is an enormous burden to the healthcare system. While some aspects of the pathomechanism of migraines remain unknown, the most accepted theory is that activation and sensitization of the trigeminovascular system are essential during migraine attacks. In recent decades, it has been suggested that ion channels may be important participants in the pathogenesis of migraine. Numerous ion channels are expressed in the peripheral and central nervous systems, including the trigeminovascular system, affecting neuron excitability, synaptic energy homeostasis, inflammatory signaling, and pain sensation...
November 21, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38054969/dynamic-landscape-of-the-intracellular-termini-of-acid-sensing-ion-channel-1a
#35
JOURNAL ARTICLE
Megan M Cullinan, Robert C Klipp, Abigail Camenisch, John R Bankston
Acid-sensing ion channels (ASICs) are trimeric proton-gated sodium channels. Recent work has shown that these channels play a role in necroptosis following prolonged acidic exposure like occurs in stroke. The C-terminus of ASIC1a is thought to mediate necroptotic cell death through interaction with receptor interacting serine threonine kinase 1 (RIPK1). This interaction is hypothesized to be inhibited at rest via an interaction between the C- and N-termini which blocks the RIPK1 binding site. Here, we use two transition metal ion FRET methods to investigate the conformational dynamics of the termini at neutral and acidic pH...
December 6, 2023: ELife
https://read.qxmd.com/read/38044383/16-channel-sipm-high-frequency-readout-with-time-over-threshold-discrimination-for-ultrafast-time-of-flight-applications
#36
JOURNAL ARTICLE
Vanessa Nadig, Matthias Hornisch, Jakob Oehm, Katrin Herweg, Volkmar Schulz, Stefan Gundacker
BACKGROUND: Over the past five years, ultrafast high-frequency (HF) readout concepts have advanced the timing performance of silicon photomultipliers (SiPMs). The shown impact in time-of-flight (TOF) techniques can further push the limits in light detection and ranging (LiDAR), time-of-flight positron-emission tomography (TOF-PET), time-of-flight computed tomography (TOF-CT) or high-energy physics (HEP). However, upscaling these electronics to a system-applicable, multi-channel readout, has remained a challenging task, posed by the use of discrete components and a high power consumption...
December 4, 2023: EJNMMI Physics
https://read.qxmd.com/read/38005640/binary-neural-networks-in-fpgas-architectures-tool-flows-and-hardware-comparisons
#37
REVIEW
Yuanxin Su, Kah Phooi Seng, Li Minn Ang, Jeremy Smith
Binary neural networks (BNNs) are variations of artificial/deep neural network (ANN/DNN) architectures that constrain the real values of weights to the binary set of numbers {-1,1}. By using binary values, BNNs can convert matrix multiplications into bitwise operations, which accelerates both training and inference and reduces hardware complexity and model sizes for implementation. Compared to traditional deep learning architectures, BNNs are a good choice for implementation in resource-constrained devices like FPGAs and ASICs...
November 17, 2023: Sensors
https://read.qxmd.com/read/38002313/probing-the-proton-gated-asic-channels-using-tetraalkylammonium-ions
#38
JOURNAL ARTICLE
Konstantin K Evlanenkov, Maxim V Nikolaev, Natalia N Potapieva, Konstantin V Bolshakov, Denis B Tikhonov
The action of tetraalkylammonium ions, from tetrametylammonium (TMA) to tetrapentylammonium (TPtA), on the recombinant and native acid-sensing ion channels (ASICs) was studied using the patch-clamp approach. The responses of ASIC1a, ASIC2a, and native heteromeric ASICs were inhibited by TPtA. The peak currents through ASIC3 were unaffected, whereas the steady-state currents were significantly potentiated. This effect was characterized by an EC50 value of 1.22 ± 0.12 mM and a maximal effect of 3.2 ± 0...
November 8, 2023: Biomolecules
https://read.qxmd.com/read/37943859/coordination-of-pickpocket-ion-channel-delivery-and-dendrite-growth-in-drosophila-sensory-neurons
#39
JOURNAL ARTICLE
Josephine W Mitchell, Ipek Midillioglu, Ethan Schauer, Bei Wang, Chun Han, Jill Wildonger
Sensory neurons enable an organism to perceive external stimuli, which is essential for survival. The sensory capacity of a neuron depends on the elaboration of its dendritic arbor and the localization of sensory ion channels to the dendritic membrane. However, it is not well understood when and how ion channels localize to growing sensory dendrites and whether their delivery is coordinated with growth of the dendritic arbor. We investigated the localization of the DEG/ENaC/ASIC ion channel Pickpocket (Ppk) in the peripheral sensory neurons of developing fruit flies...
November 9, 2023: PLoS Genetics
https://read.qxmd.com/read/37918499/amiloride-alleviates-morphine-tolerance-by-suppressing-asic3-dependent-neuroinflammation-in-the-spinal-cord
#40
JOURNAL ARTICLE
Liba Gei, Yan Yan, Wei Xing, Qiang Li, Xiangnan Chen, Fang Yan, Yan Wang, Yan Cao, Wenqi Jiang, E RiQi, DeXing Luo, YanHong Zhang, Weian Zeng, Dongtai Chen
BACKGROUND: The use of morphine in clinical medicine is severely constrained by tolerance. Therefore, it is essential to examine pharmacological therapies that suppress the development of morphine tolerance. Amiloride suppressed the expression of inflammatory cytokines by inhibiting microglial activation. Microglia play a crucial role in the establishment of morphine tolerance. Thus, we anticipated that amiloride might suppress the development of morphine tolerance. During this investigation, we assessed the impact of amiloride on mouse morphine tolerance...
October 31, 2023: European Journal of Pharmacology
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