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https://www.readbyqxmd.com/read/28912013/acid-sensing-ion-channel-1-contributes-to-normal-olfactory-function
#1
Kiara T Vann, Zhi-Gang Xiong
Acid-sensing ion channels (ASICs) are cation channels activated by protons. ASIC1a, a primary ASIC subunit in the brain, was recently characterized in the olfactory bulb. The present study tested the hypothesis that ASIC1a is essential for normal olfactory function. Olfactory behavior of wild-type (WT) and ASIC1-/- mice was evaluated by using three standard olfactory tests: (1) the buried food test, (2) the olfactory habituation test, and (3) the olfactory preference test. In buried food test, ASIC1-/- mice had significantly longer latency to uncover buried food than WT mice...
September 11, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28901620/assessment-of-the-spectral-performance-of-hybrid-photon-counting-x-ray-detectors
#2
Peter Trueb, Pietro Zambon, Christian Broennimann
PURPOSE: Hybrid Photon Counting (HPC) detectors profoundly improved x-ray diffraction experiments at third generation synchrotron facilities. Enabling the simultaneous measurement of x-ray intensities in multiple energy bins, they also have many potential applications in the field of medical imaging. A prerequisite for this is a clean spectral response. To quantify how efficiently HPC detectors are able to assign photons to the correct energy bin, a quantity called Spectral Efficiency (SE) is introduced...
September 2017: Medical Physics
https://www.readbyqxmd.com/read/28889738/introduction-to-the-highlights-of-the-26th-asic-conference
#3
Astrid Nehlig
The 26th ASIC Conference that was held in 2016 in Kunming, China has been marking the 50th anniversary of the creation of ASIC. The meeting in China was well attended by over 400 participants from all over the world and allowed fruitful exchanges among participants from all horizons of coffee science.
September 10, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28885160/a-differential-electrochemical-readout-asic-with-heterogeneous-integration-of-bio-nano-sensors-for-amperometric-sensing
#4
Sara S Ghoreishizadeh, Irene Taurino, Giovanni De Micheli, Sandro Carrara, Pantelis Georgiou
A monolithic biosensing platform is presented for miniaturized amperometric electrochemical sensing in CMOS. The system consists of a fully integrated current readout circuit for differential current measurement as well as on-die sensors developed by growing platinum nanostructures (Pt-nanoS) on top of electrodes implemented with the top metal layer. The circuit is based on the switch-capacitor technique and includes pseudodifferential integrators for concurrent sampling of the differential sensor currents...
September 5, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28858812/a-thermally-powered-isfet-array-for-on-body-ph-measurement
#5
Matthew Douthwaite, Ermis Koutsos, David C Yates, Paul D Mitcheson, Pantelis Georgiou
Recent advances in electronics and electrochemical sensors have led to an emerging class of next generation wearables, detecting analytes in biofluids such as perspiration. Most of these devices utilize ion-selective electrodes (ISEs) as a detection method; however, ion-sensitive field-effect transistors (ISFETs) offer a solution with improved integration and a low power consumption. This work presents a wearable, thermoelectrically powered system composed of an application-specific integrated circuit (ASIC), two commercial power management integrated circuits and a network of commercial thermoelectric generators (TEGs)...
August 24, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28806960/16-channel-biphasic-current-mode-programmable-charge-balanced-neural-stimulation
#6
Xiaoran Li, Shunan Zhong, James Morizio
BACKGROUND: Neural stimulation is an important method used to activate or inhibit action potentials of the neuronal anatomical targets found in the brain, central nerve and peripheral nerve. The neural stimulator system produces biphasic pulses that deliver balanced charge into tissue from single or multichannel electrodes. The timing and amplitude of these biphasic pulses are precisely controlled by the neural stimulator software or imbedded algorithms. Amplitude mismatch between the anodic current and cathodic current of the biphasic pulse will cause permanently damage for the neural tissues...
August 14, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28802647/pharmacological-modulation-of-acid-sensing-ion-channels-1a-and-3-by-amiloride-and-2-guanidine-4-methylquinazoline-gmq
#7
Thomas Besson, Eric Lingueglia, Miguel Salinas
Acid-Sensing Ion Channels (ASICs) are cation channels activated by extracellular acidification that emerge as potential pharmacological targets in pain and other neurological disorders. Here, we compare the pharmacological modulation of ASIC1a and ASIC3 channels by amiloride and 2-guanidine-4-methylquinazoline (GMQ), two compounds commonly used for their in vitro and in vivo investigation. We analyzed the effect of amiloride on the pH-dependent activation and inactivation, the relative influence of the extracellular domain and the transmembrane/cytosolic domains on the effect of amiloride and GMQ using chimeras between ASIC1a and ASIC3, and how these compounds potentiate the physiologically relevant ASIC3 sustained window current...
August 9, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28789587/light-on-a-sensory-interface-linking-the-cerebrospinal-fluid-to-motor-circuits-in-vertebrates
#8
Lydia Djenoune, Claire Wyart
The cerebrospinal fluid (CSF) is circulating around the entire central nervous system (CNS). The main function of the CSF has been thought to insure the global homeostasis of the CNS. Recent evidence indicates that the CSF also dynamically conveys signals modulating the development and the activity of the nervous system. The later observation implies that cues from the CSF could act on neurons in the brain and the spinal cord via bordering receptor cells. Candidate neurons to enable such modulation are the cerebrospinal fluid-contacting neurons (CSF-cNs) that are located precisely at the interface between the CSF and neuronal circuits...
September 2017: Journal of Neurogenetics
https://www.readbyqxmd.com/read/28730439/design-and-preparation-of-aptamer-sirna-chimeras-asics-for-targeted-cancer-therapy
#9
Sven Kruspe, Paloma H Giangrande
Conjugation of cell-internalizing DNA or RNA aptamers to tumor-suppressing siRNAs represents a novel promising approach for cancer therapy. Here we describe how to employ RNA aptamers that bind to cell surface receptors as carriers for cell-targeted siRNA (or miRNA) delivery. This protocol was optimized to improve the efficiency of the aptamer-siRNA/miRNA conjugates and facilitate its implementation in most molecular biology labs. The single working steps include (1) outlining the optimal sequences of the RNA strands bearing the aptamer and siRNA sequence, for which further (2) a dsDNA template is synthesized and then (3) transcribed into an RNA that will be (4) folded and annealed to a chemically synthesized siRNA complementary strand...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28728821/the-kinetics-and-the-permeation-properties-of-piezo-channels
#10
R Gnanasambandam, P A Gottlieb, F Sachs
Piezo channels are eukaryotic, cation-selective mechanosensitive channels (MSCs), which show rapid activation and voltage-dependent inactivation. The kinetics of these channels are largely consistent across multiple cell types and different stimulation paradigms with some minor variability. No accessory subunits that associate with Piezo channels have been reported. They are homotrimers and each ∼300kD monomer has an N-terminal propeller blade-like mechanosensing module, which can confer mechanosensing capabilities on ASIC-1 (the trimeric non-MSC, acid-sensing ion channel-1) and a C-terminal pore module, which influences conductance, selectivity, and channel inactivation...
2017: Current Topics in Membranes
https://www.readbyqxmd.com/read/28693714/psychometric-properties-of-the-spanish-version-of-the-anxiety-sensitivity-index-for-children
#11
José Fernández-Valdés, Aurora Gavino, Lidia Valderrama-Martos, Antonio Godoy, Jeff Laurent
BACKGROUND: Anxiety sensitivity is a useful construct in explaining anxiety disorders. The Anxiety Sensitivity Index for Children (ASIC) is a brief self-report designed to assess anxiety sensitivity in youth. METHOD: Students (N = 1348; ages 10-17) completed a Spanish translation of the ASIC and measures of anxiety and depression. RESULTS: Confirmatory factor analyses found that scores on the ASIC- Spanish version can be fitted to two factorial structures: A single factor and two first-order factors grouped into one higher-order factor...
August 2017: Psicothema
https://www.readbyqxmd.com/read/28688766/ligands-of-histamine-receptors-modulate-acid-sensing-ion-channels
#12
V Y Shteinikov, A S Korosteleva, T B Tikhonova, N N Potapieva, D B Tikhonov
Recently we found that synthetic compounds containing amino group linked to hydrophobic or aromatic moiety are potent modulators of the proton-gated channels (ASICs). These structures have clear similarity with ligands of histamine receptors. We have also demonstrated that histamine potentiates homomeric ASIC1a by shifting its activation dependence to less acidic conditions. In the present work the action of a series of histamine receptors ligands on recombinant ASIC1a and ASIC2a was characterized. Two types of action were found for ASIC1a...
September 2, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28674755/modulation-of-the-fmrfamide-gated-na-channel-by-external-ca-2
#13
Akihiko Fujimoto, Yu Kodani, Yasuo Furukawa
FMRFamide-gated Na(+) channel (FaNaC) is a member of the DEG/ENaC family. Amino acid sequence of the second transmembrane region (TM2) of FaNaC is quite similar to that of the acid-sensing ion channels (ASIC) of the same family. In the upper part of TM2, there are two aspartate residues (D552 and D556 in Aplysia FaNaC, AkFaNaC) which construct two negative rings in the external vestibule. In the present study, we examined the function of D552/D556 mutants of AkFaNaC in Xenopus oocytes with special interest in Ca(2+) sensitivity of FaNaC...
July 3, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28672813/a-spaceborne-synthetic-aperture-radar-partial-fixed-point-imaging-system-using-a-field-programmable-gate-array-application-specific-integrated-circuit-hybrid-heterogeneous-parallel-acceleration-technique
#14
Chen Yang, Bingyi Li, Liang Chen, Chunpeng Wei, Yizhuang Xie, He Chen, Wenyue Yu
With the development of satellite load technology and very large scale integrated (VLSI) circuit technology, onboard real-time synthetic aperture radar (SAR) imaging systems have become a solution for allowing rapid response to disasters. A key goal of the onboard SAR imaging system design is to achieve high real-time processing performance with severe size, weight, and power consumption constraints. In this paper, we analyse the computational burden of the commonly used chirp scaling (CS) SAR imaging algorithm...
June 24, 2017: Sensors
https://www.readbyqxmd.com/read/28657172/asic1a-in-neurons-is-critical-for-fear-related-behaviors
#15
R J Taugher, Y Lu, R Fan, A Ghobbeh, C J Kreple, F M Faraci, J A Wemmie
Acid-sensing ion channels (ASICs) have been implicated in fear-, addiction- and depression-related behaviors in mice. While these effects have been attributed to ASIC1A in neurons, it has been reported that ASICs may also function in nonneuronal cells. To determine if ASIC1A in neurons is indeed required, we generated neuron-specific knockout (KO) mice with floxed Asic1a alleles disrupted by Cre recombinase driven by the neuron-specific synapsin I promoter (SynAsic1a KO mice). We confirmed that Cre expression occurred in neurons, but not all neurons, and not in nonneuronal cells including astrocytes...
June 28, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28562320/asics-may-affect-gabaergic-synapses
#16
EDITORIAL
Maksim Storozhuk, Oleg Krishtal
No abstract text is available yet for this article.
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28541119/treatment-of-opioid-use-disorder-with-ibogaine-detoxification-and-drug-use-outcomes
#17
Thomas Kingsley Brown, Kenneth Alper
BACKGROUND: Ibogaine is a monoterpene indole alkaloid used in medical and nonmedical settings for the treatment of opioid use disorder. Its mechanism of action is apparently novel. There are no published prospective studies of drug use outcomes with ibogaine. OBJECTIVES: To study outcomes following opioid detoxification with ibogaine. METHODS: In this observational study, 30 subjects with DSM-IV Opioid Dependence (25 males, 5 females) received a mean total dose of 1,540 ± 920 mg ibogaine HCl...
May 25, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28528673/acid-sensing-ion-channel-pharmacology-past-present-and-future-%C3%A2
#18
Lachlan D Rash
pH is one of the most strictly controlled parameters in mammalian physiology. An extracellular pH of ~7.4 is crucial for normal physiological processes, and perturbations to this have profound effects on cell function. Acidic microenvironments occur in many physiological and pathological conditions, including inflammation, bone remodeling, ischemia, trauma, and intense synaptic activity. Cells exposed to these conditions respond in different ways, from tumor cells that thrive to neurons that are either suppressed or hyperactivated, often fatally...
2017: Advances in Pharmacology
https://www.readbyqxmd.com/read/28518134/asic1-and-asic3-contribute-to-acidity-induced-emt-of-pancreatic-cancer-through-activating-ca-2-rhoa-pathway
#19
Shuai Zhu, Hai-Yun Zhou, Shi-Chang Deng, Shi-Jiang Deng, Chi He, Xiang Li, Jing-Yuan Chen, Yan Jin, Zhuang-Li Hu, Fang Wang, Chun-You Wang, Gang Zhao
Extracellular acid can have important effects on cancer cells. Acid-sensing ion channels (ASICs), which emerged as key receptors for extracellular acidic pH, are differently expressed during various diseases and have been implicated in underlying pathogenesis. This study reports that ASIC1 and ASIC3 are mainly expressed on membrane of pancreatic cancer cells and upregulated in pancreatic cancer tissues. ASIC1 and ASIC3 are responsible for an acidity-induced inward current, which is required for elevation of intracellular Ca(2+) concentration ([Ca(2+)]i)...
May 18, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28516169/hybrid-pixel-waveform-hpwf-enabled-cdte-detectors-for-small-animal-gamma-ray-imaging-applications
#20
A Groll, K Kim, H Bhatia, J C Zhang, J H Wang, Z M Shen, L Cai, J Dutta, Q Li, L J Meng
This paper presents the design and preliminary evaluation of small-pixel CdTe gamma ray detectors equipped with a hybrid pixel-waveform (HPWF) readout system for gamma ray imaging applications with additional discussion on CZT due to its similarity. The HPWF readout system utilizes a pixelated anode readout circuitry which is designed to only provide the pixel address. This readout circuitry works in coincidence with a high-speed digitizer to sample the cathode waveform which provides the energy, timing, and depth-of-interaction (DOI) information...
January 2017: IEEE transactions on radiation and plasma medical sciences
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