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https://www.readbyqxmd.com/read/27879566/the-effect-of-an-acid-sensing-ion-channels-asics-inhibitor-on-pain-related-behavior-by-nucleus-pulposus-applied-on-the-nerve-root-in-rats
#1
Yoshihiro Kobayashi, Miho Sekiguchi, Shin-Ichi Konno
STUDY DESIGN: Controlled, interventional, animal study. OBJECTIVE: To examine the effect of an inhibitor of acid-sensing ion channel 3 (ASIC3) on pain-related behavior induced by application of the nucleus pulposus (NP) onto the dorsal root ganglion (DRG) in rats. SUMMARY OF BACKGROUND DATA: ASIC3 is associated with acidosis pain in inflamed or ischemic tissues and is expressed in sensory neurons and NP cells. The ASIC3 inhibitor, APETx2, increases the mechanical threshold of pain in models of knee osteoarthritis or postoperative pain...
November 22, 2016: Spine
https://www.readbyqxmd.com/read/27853274/acidic-ph-promotes-intervertebral-disc-degeneration-acid-sensing-ion-channel-3-as-a-potential-therapeutic-target
#2
Hamish T J Gilbert, Nathan Hodson, Pauline Baird, Stephen M Richardson, Judith A Hoyland
The aetiology of intervertebral disc (IVD) degeneration remains poorly understood. Painful IVD degeneration is associated with an acidic intradiscal pH but the response of NP cells to this aberrant microenvironmental factor remains to be fully characterised. The aim here was to address the hypothesis that acidic pH, similar to that found in degenerate IVDs, leads to the altered cell/functional phenotype observed during IVD degeneration, and to investigate the involvement of acid-sensing ion channel (ASIC) -3 in the response...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27836602/a-biomimetic-bioelectronic-tongue-a-switch-for-on-and-off-response-of-acid-sensations
#3
Wei Zhang, Peihua Chen, Lianqun Zhou, Zhen Qin, Keqiang Gao, Jia Yao, Chuanyu Li, Ping Wang
The perception of sour taste in mammals is important for its basic modality properties and avoiding toxic substances. We explore a biomimetic bioelectronic tongue, which integrate MEA (microelectrode array) and taste receptor cell for acid detection as a switch. However, the acid-sensing mechanism and coding of the taste receptor cells in the periphery is not well understood, with long-standing debate. Therefore, we firstly construct a Hodgkin-Huxley type mathematical model of whole-cell acid-sensing taste receptor cells based on the electrophysiologic patch clamp recordings with different acid sensitive receptor expressing and different acidic stimulations...
October 27, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27827430/lactate-is-a-potent-inhibitor-of-the-capsaicin-receptor-trpv1
#4
Jeanne de la Roche, Isabella Walther, Waleria Leonow, Axel Hage, Mirjam Eberhardt, Martin Fischer, Peter W Reeh, Susanne Sauer, Andreas Leffler
Tissue ischemia results in an accumulation of lactate and local or systemic lactic acidosis. In nociceptive sensory neurons, lactate was reported to sensitize or activate the transient receptor potential ion channel TRPA1 and acid-sensing ion channels (ASICs). However, it is unclear how lactate modulates the TRPV1 regarded as the main sensor for acidosis in sensory neurons. In this study we investigated the effects of lactate (LA) on recombinant and native TRPV1 channels and on TRPV1-mediated release of neuropeptides from mouse nerves...
November 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27820848/acid-sensing-ion-channel-1a-contributes-to-airway-hyperreactivity-in-mice
#5
Leah R Reznikov, David K Meyerholz, Ryan J Adam, Mahmoud Abou Alaiwa, Omar Jaffer, Andrew S Michalski, Linda S Powers, Margaret P Price, David A Stoltz, Michael J Welsh
Neurons innervating the airways contribute to airway hyperreactivity (AHR), a hallmark feature of asthma. Several observations suggested that acid-sensing ion channels (ASICs), neuronal cation channels activated by protons, might contribute to AHR. For example, ASICs are found in vagal sensory neurons that innervate airways, and asthmatic airways can become acidic. Moreover, airway acidification activates ASIC currents and depolarizes neurons innervating airways. We found ASIC1a protein in vagal ganglia neurons, but not airway epithelium or smooth muscle...
2016: PloS One
https://www.readbyqxmd.com/read/27820820/asic1a-deficient-mice-show-unaltered-neurodegeneration-in-the-subacute-mptp-model-of-parkinson-disease
#6
Daniel Komnig, Silke Imgrund, Arno Reich, Stefan Gründer, Björn H Falkenburger
Inflammation contributes to the death of dopaminergic neurons in Parkinson disease and can be accompanied by acidification of extracellular pH, which may activate acid-sensing ion channels (ASIC). Accordingly, amiloride, a non-selective inhibitor of ASIC, was protective in an acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson disease. To complement these findings we determined MPTP toxicity in mice deficient for ASIC1a, the most common ASIC isoform in neurons. MPTP was applied i...
2016: PloS One
https://www.readbyqxmd.com/read/27792131/a-low-noise-cmos-readout-based-on-a-polymer-coated-saw-array-for-miniature-electronic-nose
#7
Cheng-Chun Wu, Szu-Chieh Liu, Shih-Wen Chiu, Kea-Tiong Tang
An electronic nose (E-Nose) is one of the applications for surface acoustic wave (SAW) sensors. In this paper, we present a low-noise complementary metal-oxide-semiconductor (CMOS) readout application-specific integrated circuit (ASIC) based on an SAW sensor array for achieving a miniature E-Nose. The center frequency of the SAW sensors was measured to be approximately 114 MHz. Because of interference between the sensors, we designed a low-noise CMOS frequency readout circuit to enable the SAW sensor to obtain frequency variation...
October 25, 2016: Sensors
https://www.readbyqxmd.com/read/27770439/non-proton-ligand-sensing-domain-of-acid-sensing-ion-channel-3-is-required-for-itch-sensation
#8
Zhen Lei, Abdul Sami Shaikh, Wenshuai Zheng, Xiao Yu, Jingui Yu, Jingxin Li
Itch, the unpleasant sensation that evokes a desire to scratch, accompanies numerous skin and nervous system disorders. However, the molecular mechanisms of itch are unclear. Acid sensing ion channel 3 (ASIC3) is a sensor of acidic and primary inflammatory pain. The whole-cell patch-clamp technique was used to determine the effect of Chloroquine (CQ)on ASICs currents in primary sensory neurons or the Chinese hamster ovary (CHO) cells transfected with rat-ASIC1a or- ASIC3. Site-directed mutagenesis of plasmid was performed...
October 22, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27768691/modeling-and-simulation-of-the-economics-of-mining-in-the-bitcoin-market
#9
Luisanna Cocco, Michele Marchesi
In January 3, 2009, Satoshi Nakamoto gave rise to the "Bitcoin Blockchain", creating the first block of the chain hashing on his computer's central processing unit (CPU). Since then, the hash calculations to mine Bitcoin have been getting more and more complex, and consequently the mining hardware evolved to adapt to this increasing difficulty. Three generations of mining hardware have followed the CPU's generation. They are GPU's, FPGA's and ASIC's generations. This work presents an agent-based artificial market model of the Bitcoin mining process and of the Bitcoin transactions...
2016: PloS One
https://www.readbyqxmd.com/read/27760555/a-modulatory-role-of-asics-on-gabaergic-synapses-in-rat-hippocampal-cell-cultures
#10
Maksim Storozhuk, Elena Kondratskaya, Lyudmila Nikolaenko, Oleg Krishtal
Rapid acidification occurring during synaptic vesicle release can activate acid-sensing ion channels (ASICs) both on pre- and postsynaptic neurons. In the latter case, a fraction of postsynaptic current would be mediated by cation-selective acid-sensing ion channels. Additionally, in both cases, activation of acid-sensing ion channels could modulate synaptic strength by affecting transmitter release and/or sensitivity of postsynaptic receptors. To address potential involvement of acid-sensing ion channels in mediation/modulation of synaptic transmission at hippocampal GABAergic synapses, we studied effects of three structurally different blockers of acid-sensing ion channels on evoked postsynaptic currents using the patch-clamp technique...
October 19, 2016: Molecular Brain
https://www.readbyqxmd.com/read/27740477/4-d-ice-a-2-d-array-transducer-with-integrated-asic-in-a-10-fr-catheter-for-real-time-3-d-intracardiac-echocardiography
#11
Douglas Wildes, Warren Lee, Bruno Haider, Scott Cogan, Krishnakumar Sundaresan, David M Mills, Christopher Yetter, Patrick H Hart, Christopher R Haun, Mikael Concepcion, Johan Kirkhorn, Marc Bitoun
We developed a 2.5 ×6.6 mm (2) 2 -D array transducer with integrated transmit/receive application-specific integrated circuit (ASIC) for real-time 3-D intracardiac echocardiography (4-D ICE) applications. The ASIC and transducer design were optimized so that the high-voltage transmit, low-voltage time-gain control and preamp, subaperture beamformer, and digital control circuits for each transducer element all fit within the 0.019-mm (2) area of the element. The transducer assembly was deployed in a 10-Fr (3...
December 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/27698929/enac-deg-in-tumor-development-and-progression
#12
Cui Liu, Li-Li Zhu, Si-Guang Xu, Hong-Long Ji, Xiu-Min Li
The epithelial Na(+) channel/degenerin (ENaC/DEG) superfamily, including the acid-sensing ion channels (ASICs), is characterized by a high degree of similarity in structure but highly diverse in physiological functions. These ion channels have been shown to be important in several physiological functions of normal epithelial cells, including salt homeostasis, fluid transportation and cell mobility. There is increasing evidence suggesting that ENaC/DEG channels are critically engaged in cancer cell biology, such as proliferation, migration, invasion and apoptosis, playing a role in tumor development and progression...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27687800/participation-of-peripheral-trpv1-trpv4-trpa1-and-asic-in-a-magnesium-sulfate-induced-local-pain-model-in-rat
#13
Dragana Srebro, Sonja Vučković, Milica Prostran
We previously showed that magnesium sulfate (MS) has systemic antinociceptive and local peripheral pronociceptive effects. The role of transient receptor potential (TRP) channels and acid-sensing ion channels (ASICs) in the mechanism of action of MS has not been investigated in detail. The aim of this study was to explore the participation of TRP channels in the pronociceptive action of MS in rats after its intraplantar injection. The paw withdrawal threshold (PWT) to mechanical stimuli was measured by the electronic von Frey test...
December 17, 2016: Neuroscience
https://www.readbyqxmd.com/read/27667176/integrative-modeling-reveals-annexin-a2-mediated-epigenetic-control-of-mesenchymal-glioblastoma
#14
Teresia Kling, Roberto Ferrarese, Darren Ó hAilín, Patrik Johansson, Dieter Henrik Heiland, Fangping Dai, Ioannis Vasilikos, Astrid Weyerbrock, Rebecka Jörnsten, Maria Stella Carro, Sven Nelander
Glioblastomas are characterized by transcriptionally distinct subtypes, but despite possible clinical relevance, their regulation remains poorly understood. The commonly used molecular classification systems for GBM all identify a subtype with high expression of mesenchymal marker transcripts, strongly associated with invasive growth. We used a comprehensive data-driven network modeling technique (augmented sparse inverse covariance selection, aSICS) to define separate genomic, epigenetic, and transcriptional regulators of glioblastoma subtypes...
September 18, 2016: EBioMedicine
https://www.readbyqxmd.com/read/27662686/towards-a-reduced-wire-interface-for-cmut-based-intravascular-ultrasound-imaging-systems
#15
Jaemyung Lim, Coskun Tekes, F Levent Degertekin, Maysam Ghovanloo
Having intravascular ultrasound (IVUS) imaging capability on guide wires used in cardiovascular interventions may eliminate the need for separate IVUS catheters and expand the use of IVUS in a larger portion of the vasculature. High frequency capacitive micro machined ultrasonic transducer (CMUT) arrays should be integrated with interface electronics and placed on the guide wire for this purpose. Besides small size, this system-on-a-chip (SoC) front-end should connect to the back-end imaging system with a minimum number of wires to preserve the critical mechanical properties of the guide wire...
September 20, 2016: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/27638107/an-implantable-eng-detector-with-in-system-velocity-selective-recording-vsr-capability
#16
Chris Clarke, Robert Rieger, Martin Schuettler, Nick Donaldson, John Taylor
Detection and classification of electroneurogram (ENG) signals in the peripheral nervous system can be achieved by velocity selective recording (VSR) using multi-electrode arrays. This paper describes an implantable VSR-based ENG recording system representing a significant development in the field since it is the first system of its type that can record naturally evoked ENG and be interfaced wirelessly using a low data rate transcutaneous link. The system consists of two CMOS ASICs one of which is placed close to the multi-electrode cuff array (MEC), whilst the other is mounted close to the wireless link...
September 16, 2016: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/27634419/the-interaction-between-ngf-induced-hyperalgesia-and-acid-provoked-pain-in-the-infrapatellar-fat-pad-and-tibialis-anterior-muscle-of-healthy-volunteers
#17
T K Munkholm, L Arendt-Nielsen
BACKGROUND: Tissue pH is lowered in inflamed tissues, and the increased proton concentration activates acid-sensing ion channels (ASICs), contributing to pain and hyperalgesia. ASICs can be upregulated by nerve growth factor (NGF). The aim of this study was to investigate two new human experimental pain models combining NGF- and acid-induced pain in a randomized, controlled, double-blind study. METHODS: In experiment 1, volunteers (N = 16) received an injection of either NGF or isotonic saline in each infrapatellar fat pad (IFP)...
September 15, 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27589758/adaptive-sampling-based-information-collection-for-wireless-body-area-networks
#18
Xiaobin Xu, Fang Zhao, Wendong Wang, Hui Tian
To collect important health information, WBAN applications typically sense data at a high frequency. However, limited by the quality of wireless link, the uploading of sensed data has an upper frequency. To reduce upload frequency, most of the existing WBAN data collection approaches collect data with a tolerable error. These approaches can guarantee precision of the collected data, but they are not able to ensure that the upload frequency is within the upper frequency. Some traditional sampling based approaches can control upload frequency directly, however, they usually have a high loss of information...
2016: Sensors
https://www.readbyqxmd.com/read/27580245/asic-and-enac-type-sodium-channels-conformational-states-and-the-structures-of-the-ion-selectivity-filters
#19
Israel Hanukoglu
The acid-sensing ion channels (ASICs) and epithelial sodium channels (ENaC) are members of a superfamily of channels that play critical roles in mechanosensation, chemosensation, nociception, and regulation of blood volume and pressure. These channels look and function like a tripartite funnel that directs the flow of Na(+) ions into the cytoplasm via the channel pore in the membrane. The subunits that form these channels share a common structure with two transmembrane segments (TM1 and TM2) and a large extracellular part...
August 31, 2016: FEBS Journal
https://www.readbyqxmd.com/read/27574729/histamine-selectively-potentiates-acid-sensing-ion-channel-1a
#20
Elina I Nagaeva, Tatiana B Tikhonova, Lev G Magazanik, Denis B Tikhonov
Although acid-sensitive ion channels (ASICs) play an important role in brain functions, the exact mechanism of their physiological activation remain unclear. A possible answer to the intriguing question is that some presently unknown endogenous ligand(s) positively modulate ASICs and enhance their responses to physiologically significant level. In the present work we found that histamine selectively potentiates ASIC1a homomers in CHO cells. Action of histamine was particularly pronounced at modest acidifications, which cause minor response...
October 6, 2016: Neuroscience Letters
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