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https://www.readbyqxmd.com/read/28528673/acid-sensing-ion-channel-pharmacology-past-present-and-future-%C3%A2
#1
Lachlan D Rash
pH is one of the most strictly controlled parameters in mammalian physiology. An extracellular pH of ~7.4 is crucial for normal physiological processes, and perturbations to this have profound effects on cell function. Acidic microenvironments occur in many physiological and pathological conditions, including inflammation, bone remodeling, ischemia, trauma, and intense synaptic activity. Cells exposed to these conditions respond in different ways, from tumor cells that thrive to neurons that are either suppressed or hyperactivated, often fatally...
2017: Advances in Pharmacology
https://www.readbyqxmd.com/read/28518134/asic1-and-asic3-contribute-to-acidity-induced-emt-of-pancreatic-cancer-through-activating-ca-2-rhoa-pathway
#2
Shuai Zhu, Hai-Yun Zhou, Shi-Chang Deng, Shi-Jiang Deng, Chi He, Xiang Li, Jing-Yuan Chen, Yan Jin, Zhuang-Li Hu, Fang Wang, Chun-You Wang, Gang Zhao
Extracellular acid can have important effects on cancer cells. Acid-sensing ion channels (ASICs), which emerged as key receptors for extracellular acidic pH, are differently expressed during various diseases and have been implicated in underlying pathogenesis. This study reports that ASIC1 and ASIC3 are mainly expressed on membrane of pancreatic cancer cells and upregulated in pancreatic cancer tissues. ASIC1 and ASIC3 are responsible for an acidity-induced inward current, which is required for elevation of intracellular Ca(2+) concentration ([Ca(2+)]i)...
May 18, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28516169/hybrid-pixel-waveform-hpwf-enabled-cdte-detectors-for-small-animal-gamma-ray-imaging-applications
#3
A Groll, K Kim, H Bhatia, J C Zhang, J H Wang, Z M Shen, L Cai, J Dutta, Q Li, L J Meng
This paper presents the design and preliminary evaluation of small-pixel CdTe gamma ray detectors equipped with a hybrid pixel-waveform (HPWF) readout system for gamma ray imaging applications with additional discussion on CZT due to its similarity. The HPWF readout system utilizes a pixelated anode readout circuitry which is designed to only provide the pixel address. This readout circuitry works in coincidence with a high-speed digitizer to sample the cathode waveform which provides the energy, timing, and depth-of-interaction (DOI) information...
January 2017: IEEE Trans Radiat Plasma Med Sci
https://www.readbyqxmd.com/read/28504937/ultrasonic-fingerprint-sensor-with-transmit-beamforming-based-on-a-pmut-array-bonded-to-cmos-circuitry
#4
Xiaoyue Jiang, Hao-Yen Tang, Yipeng Lu, Eldwin Ng, Julius Tsai, Bernhard Boser, David Horsley
In this paper, we present a single-chip 65x42 element ultrasonic pulse-echo fingerprint sensor with transmit beamforming based on piezoelectric micromachined ultrasonic transducers (PMUTs) directly bonded to a CMOS readout ASIC. The readout ASIC was realized in a standard 180 nm CMOS process with a 24V high voltage transistor option. Pulse-echo measurements are performed column-by-column in sequence using either one column or five columns to transmit the ultrasonic pulse at 20 MHz. Transmit beamforming is used to focus the ultrasonic beam at the imaging plane where the finger is located, increasing the ultrasonic pressure and narrowing the 3dB beam-width to 50 microns, a factor of 6...
May 11, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28498103/a-selectivity-filter-at-the-intracellular-end-of-the-acid-sensing-ion-channel-pore
#5
Timothy Lynagh, Emelie Flood, Céline Boiteux, Matthias Wulf, Vitaly V Komnatnyy, Janne M Colding, Toby W Allen, Stephan A Pless
Increased extracellular proton concentrations during neurotransmission are converted to excitatory sodium influx by acid-sensing ion channels (ASICs). 10-fold sodium/potassium selectivity in ASICs has long been attributed to a central constriction in the channel pore, but experimental verification is lacking due to the sensitivity of this structure to conventional manipulations. Here, we explored the basis for ion selectivity by incorporating unnatural amino acids into the channel, engineering channel stoichiometry and performing free energy simulations...
May 12, 2017: ELife
https://www.readbyqxmd.com/read/28489547/a-172-%C3%AE-w-compressively-sampled-photoplethysmographic-ppg-readout-asic-with-heart-rate-estimation-directly-from-compressively-sampled-data
#6
Venkata Rajesh Pamula, Jose Manuel Valero-Sarmiento, Long Yan, Alper Bozkurt, Chris Van Hoof, Nick Van Helleputte, Refet Firat Yazicioglu, Marian Verhelst
A compressive sampling (CS) photoplethysmographic (PPG) readout with embedded feature extraction to estimate heart rate (HR) directly from compressively sampled data is presented. It integrates a low-power analog front end together with a digital back end to perform feature extraction to estimate the average HR over a 4 s interval directly from compressively sampled PPG data. The application-specified integrated circuit (ASIC) supports uniform sampling mode (1x compression) as well as CS modes with compression ratios of 8x, 10x, and 30x...
May 8, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28472753/chemical-toxicity-and-radioactivity-of-depleted-uranium-the-evidence-from-in-vivo-and-in-vitro-studies
#7
REVIEW
Adna Asic, Amina Kurtovic-Kozaric, Larisa Besic, Lejla Mehinovic, Azra Hasic, Mirza Kozaric, Mirsada Hukic, Damir Marjanovic
The main aim of this review is to summarize and discuss the current state of knowledge on chemical toxicity and radioactivity of depleted uranium (DU) and their effect on living systems and cell lines. This was done by presenting a summary of previous investigations conducted on different mammalian body systems and cell cultures in terms of potential changes caused by either chemical toxicity or radioactivity of DU. In addition, the authors aimed to point out the limitations of those studies and possible future directions...
May 1, 2017: Environmental Research
https://www.readbyqxmd.com/read/28461138/distribution-of-asic4-transcripts-in-the-adult-wild-type-mouse-brain
#8
M Hoshikawa, A Kato, H Hojo, Y Shibata, N Kumamoto, M Watanabe, S Ugawa
Acid-sensing ion channel 4 (ASIC4) belongs to the ASIC gene family of neuronal proton-gated cation channels, and is the least understood subtype among the members. Previous studies of ASIC4 expression in the mammalian central nervous system have shown that ASIC4 is abundantly expressed in the spinal cord and in various brain regions, such as the cerebral cortex, the hippocampus, and the cerebellum. However, the detailed distribution of ASIC4 transcripts in mammalian brains still remains to be elucidated. In the present study, radioactive in situ hybridization histochemistry with an ASIC4-specific cRNA probe was performed on wild-type mouse brains, followed by X-gal staining experiments with Asic4-lacZ reporter mice Asic4(tm1a(KOMP)Mbp)...
April 29, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28459831/parallel-point-multiplication-architecture-using-combined-group-operations-for-high-speed-cryptographic-applications
#9
Md Selim Hossain, Ehsan Saeedi, Yinan Kong
In this paper, we propose a novel parallel architecture for fast hardware implementation of elliptic curve point multiplication (ECPM), which is the key operation of an elliptic curve cryptography processor. The point multiplication over binary fields is synthesized on both FPGA and ASIC technology by designing fast elliptic curve group operations in Jacobian projective coordinates. A novel combined point doubling and point addition (PDPA) architecture is proposed for group operations to achieve high speed and low hardware requirements for ECPM...
2017: PloS One
https://www.readbyqxmd.com/read/28457973/acid-sensing-ion-channel-asic-structure-and-function-insights-from-spider-snake-and-sea-anemone-venoms
#10
REVIEW
Ben Cristofori-Armstrong, Lachlan D Rash
Acid-sensing ion channels (ASICs) are proton-activated cation channels that are expressed in a variety of neuronal and non-neuronal tissues. As proton-gated channels, they have been implicated in many pathophysiological conditions where pH is perturbed. Venom derived compounds represent the most potent and selective modulators of ASICs described to date, and thus have been invaluable as pharmacological tools to study ASIC structure, function, and biological roles. There are now ten ASIC modulators described from animal venoms, with those from snakes and spiders favouring ASIC1, while the sea anemones preferentially target ASIC3...
April 27, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28443846/on-chip-enzymatic-microbiofuel-cell-powered-integrated-circuits
#11
Andrew G Mark, Emmanuel Suraniti, Jérôme Roche, Harald Richter, Alexander Kuhn, Nicolas Mano, Peer Fischer
A variety of diagnostic and therapeutic medical technologies rely on long term implantation of an electronic device to monitor or regulate a patient's condition. One proposed approach to powering these devices is to use a biofuel cell to convert the chemical energy from blood nutrients into electrical current to supply the electronics. We present here an enzymatic microbiofuel cell whose electrodes are directly integrated into a digital electronic circuit. Glucose oxidizing and oxygen reducing enzymes are immobilized on microelectrodes of an application specific integrated circuit (ASIC) using redox hydrogels to produce an enzymatic biofuel cell, capable of harvesting electrical power from just a single droplet of 5 mM glucose solution...
April 26, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28428534/expression-of-acid-sensing-ion-channels-in-renal-tubular-epithelial-cells-and-their-role-in-patients-with-henoch-sch%C3%A3-nlein-purpura-nephritis
#12
Li-Ping Yuan, Yan Bo, Zhang Qin, Hua Ran, Wang Li, Yu-Fei Li, Gui Ming
BACKGROUND Acid-sensing ion channels (ASICs) are ligand-gated cation channels activated by extracellular protons. However, the role of ASICs in kidney diseases remains uncertain. This study investigated ASICs expression in kidney tissues and their role in the development of Henoch-Schönlein purpura nephritis (HSPN). MATERIAL AND METHODS The expression of ASIC subunits was examined by immunochemical techniques in the kidney tissue from HSPN patients. Acid-induced ASICs expression in cultured renal tubular epithelial cells was determined by quantitative RT-PCR analysis...
April 21, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28396446/identification-of-a-cono-rfamide-from-the-venom-of-conus-textile-that-targets-asic3-and-enhances-muscle-pain
#13
Catharina Reimers, Cheng-Han Lee, Hubert Kalbacher, Yuemin Tian, Chih-Hsien Hung, Axel Schmidt, Lea Prokop, Silke Kauferstein, Dietrich Mebs, Chih-Cheng Chen, Stefan Gründer
Acid-sensing ion channels (ASICs) are proton-gated Na(+) channels that are expressed throughout the nervous system. ASICs have been implicated in several neuronal disorders, like ischemic stroke, neuronal inflammation, and pathological pain. Several toxins from venomous animals have been identified that target ASICs with high specificity and potency. These toxins are extremely useful in providing protein pharmacophores and to characterize function and structure of ASICs. Marine cone snails contain a high diversity of toxins in their venom such as conotoxins, which are short polypeptides stabilized by disulfide bonds, and conopeptides, which have no or only one disulfide bond...
April 25, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28395154/meta-analysis-of-depleted-uranium-levels-in-the-balkan-region
#14
Larisa Besic, Imer Muhovic, Adna Asic, Amina Kurtovic-Kozaric
In recent years, contradicting data has been published on the connection between the presence of depleted uranium and an increased cancer incidence among military personnel deployed in the Balkans during the 1992-1999 wars. This has led to numerous research articles investigating possible depleted uranium contamination of the afflicted regions of the Balkan Peninsula, namely Bosnia & Herzegovina, Serbia, Kosovo and Montenegro. The aim of this study was to collect data from previously published reports investigating the levels of depleted uranium in the Balkans and to present the data in the form of a meta-analysis...
June 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28391213/integration-of-low-power-asic-and-mems-sensors-for-monitoring-gastrointestinal-tract-using-a-wireless-capsule-system
#15
Md Shamsul Arefin, Jean-Michel Redoute, Mehmet Yuce
This paper presents a wireless capsule microsystem to detect and monitor pH, pressure, and temperature of the gastrointestinal (GI) tract in real-time. This research contributes to the integration of sensors (microfabricated capacitive pH, capacitive pressure, and resistive temperature sensors), frequency modulation and pulse-width modulation based interface IC circuits, microcontroller, and transceiver with meandered conformal antenna for the development of a capsule system. The challenges associated with the system miniaturization, higher sensitivity and resolution of sensors, and lower power consumption of interface circuits are addressed...
April 4, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28384246/proton-and-non-proton-activation-of-asic-channels
#16
Ivan Gautschi, Miguel Xavier van Bemmelen, Laurent Schild
The Acid-Sensing Ion Channels (ASIC) exhibit a fast desensitizing current when activated by pH values below 7.0. By contrast, non-proton ligands are able to trigger sustained ASIC currents at physiological pHs. To analyze the functional basis of the ASIC desensitizing and sustained currents, we have used ASIC1a and ASIC2a mutants with a cysteine in the pore vestibule for covalent binding of different sulfhydryl reagents. We found that ASIC1a and ASIC2a exhibit two distinct currents, a proton-induced desensitizing current and a sustained current triggered by sulfhydryl reagents...
2017: PloS One
https://www.readbyqxmd.com/read/28375388/asic-chipset-design-to-generate-block-based-complex-holographic-video
#17
Young-Ho Seo, Yoon-Hyuk Lee, Dong-Wook Kim
In this paper, we propose a new hardware architecture implemented as a very large scaled integrated circuit by using an application-specific integrated circuit technology, where block-based calculations are used to generate holograms. The proposed hardware is structured to produce a part of a hologram in the block units in parallel. A block of a hologram is calculated using an object point, and then the calculation is repeated for all object points to obtain intermediate results that are accumulated to produce the final block of a hologram...
March 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/28332558/multiple-h-sensors-mediate-the-extracellular-acidification-induced-ca-2-i-elevation-in-cultured-rat-ventricular-cardiomyocytes
#18
Yuan-Lang Hu, Xue Mi, Chao Huang, Hui-Fang Wang, Jian-Ren Song, Qing Shu, Lan Ni, Jian-Guo Chen, Fang Wang, Zhuang-Li Hu
Acidosis has been known to cause "Ca(2+) transients", however, the mechanism is still uncertain. Here, we demonstrated that multiple H(+) sensors, such as ASICs, TRPV1 and proton-sensing G protein coupled receptors (GPCRs) are involved in extracellular acidification-induced intracellular calcium ([Ca(2+)]i) elevation. By using calcium imaging measures, we observed that both ASIC and TRPV1 channels inhibitors suppressed the [Ca(2+)]i elevation induced by extracellular acidosis in cultured rat cardiac myocytes...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28327374/discovery-and-molecular-interaction-studies-of-a-highly-stable-tarantula-peptide-modulator-of-acid-sensing-ion-channel-1
#19
REVIEW
Sing Yan Er, Ben Cristofori-Armstrong, Pierre Escoubas, Lachlan D Rash
Acute pharmacological inhibition of acid-sensing ion channel 1a (ASIC1a) is efficacious in rodent models in alleviating symptoms of neurological diseases such as stroke and multiple sclerosis. Thus, ASIC1a is a promising therapeutic target and selective ligands that modulate it are invaluable research tools and potential therapeutic leads. Spider venoms have provided an abundance of voltage-gated ion channel modulators, however, only one ASIC modulator (PcTx1) has so far been isolated from this source. Here we report the discovery, characterization, and chemical stability of a second spider venom peptide that potently modulates ASIC1a and ASIC1b, and investigate the molecular basis for its subtype selectivity...
March 18, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28321113/acid-sensing-ion-channel-1a-in-the-amygdala-is-involved-in-pain-and-anxiety-related-behaviours-associated-with-arthritis
#20
Youssef Aissouni, Abderrahim El Guerrab, Al Mahdy Hamieh, Jérémy Ferrier, Maryse Chalus, Diane Lemaire, Stéphanie Grégoire, Monique Etienne, Alain Eschalier, Denis Ardid, Eric Lingueglia, Fabien Marchand
Chronic pain is associated with anxiety and depression episodes. The amygdala plays a key role in the relationship between emotional responses and chronic pain. Here, we investigated the role of Acid-Sensing Ion Channels 1a within the basolateral amygdala (BLA), in pain and associated anxiety in a rat model of monoarthritis (MoAr). Administration within the BLA of PcTx1 or mambalgin-1, two specific inhibitors of ASIC1a-containing channels significantly inhibited pain and anxiety-related behaviours in MoAr rats...
March 2, 2017: Scientific Reports
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