keyword
https://read.qxmd.com/read/38462456/nocistatin-and-products-of-its-proteolysis-are-dual-modulators-of-type-3-acid-sensing-ion-channels-asic3-with-algesic-and-analgesic-properties
#1
JOURNAL ARTICLE
Dmitry I Osmakov, Nadezhda V Tarasova, Andrey A Nedorubov, Victor A Palikov, Yulia A Palikova, Igor A Dyachenko, Yaroslav A Andreev, Sergey A Kozlov
The neuropeptide nocistatin (NS) is expressed by the nervous system cells and neutrophils as a part of a precursor protein and can undergo stepwise limited proteolysis. Previously, it was shown that rat NS (rNS) is able to activate acid-sensing ion channels (ASICs) and that this effect correlates with the acidic nature of NS. Here, we investigated changes in the properties of rNS in the course of its proteolytic degradation by comparing the effects of the full-size rNS and its two cleavage fragments on the rat isoform 3 ASICs (ASIC3) expressed in X...
December 2023: Biochemistry. Biokhimii︠a︡
https://read.qxmd.com/read/38439995/stochastic-computing-convolutional-neural-network-architecture-reinvented-for-highly-efficient-artificial-intelligence-workload-on-field-programmable-gate-array
#2
JOURNAL ARTICLE
Yang Yang Lee, Zaini Abdul Halim, Mohd Nadhir Ab Wahab, Tarik Adnan Almohamad
Stochastic computing (SC) has a substantial amount of study on application-specific integrated circuit (ASIC) design for artificial intelligence (AI) edge computing, especially the convolutional neural network (CNN) algorithm. However, SC has little to no optimization on field-programmable gate array (FPGA). Scaling up the ASIC logic without FPGA-oriented designs is inefficient, while aggregating thousands of bitstreams is still challenging in the conventional SC. This research has reinvented several FPGA-efficient 8-bit SC CNN computing architectures, i...
2024: Research: a science partner journal
https://read.qxmd.com/read/38437072/a-wireless-multimodal-physiological-monitoring-asic-for-animal-health-monitoring-injectable-devices
#3
JOURNAL ARTICLE
Linran Zhao, Raymond G Stephany, Yiming Han, Parvez Ahmmed, Tzu-Ping Huang, Alper Bozkurt, Yaoyao Jia
Utilizing injectable devices for monitoring animal health offers several advantages over traditional wearable devices, including improved signal-to-noise ratio (SNR) and enhanced immunity to motion artifacts. We present a wireless application-specific integrated circuit (ASIC) for injectable devices. The ASIC has multiple physiological sensing modalities including body temperature monitoring, electrocardiography (ECG), and photoplethysmography (PPG). The ASIC fabricated using the CMOS 180 nm process is sized to fit into an injectable microchip implant...
March 4, 2024: IEEE Transactions on Biomedical Circuits and Systems
https://read.qxmd.com/read/38437070/a-spatially-diverse-2tx-3rx-galvanic-coupled-transdural-telemetry-for-tether-less-distributed-brain-computer-interfaces
#4
JOURNAL ARTICLE
Chengyao Shi, Yuming He, Marios Gourdouparis, Guido Dolmans, Yao-Hong Liu
A near-field galvanic coupled transdural telemetry ASICs for intracortical brain-computer interfaces is presented. The proposed design features a two channels transmitter and three channels receiver (2TX-3RX) topology, which introduces spatial diversity to effectively mitigate misalignments (both lateral and rotational) between the brain and the skull and recovers the path loss by 13 dB when the RX is in the worst-case blind spot. This spatial diversity also allows the presented telemetry to support the spatial division multiplexing required for a high-capacity multi-implant distributed network...
March 4, 2024: IEEE Transactions on Biomedical Circuits and Systems
https://read.qxmd.com/read/38434008/machine-learning-algorithms-for-fpga-implementation-in-biomedical-engineering-applications-a-review
#5
REVIEW
Morteza Babaee Altman, Wenbin Wan, Amineh Sadat Hosseini, Saber Arabi Nowdeh, Masoumeh Alizadeh
Field Programmable Gate Arrays (FPGAs) are integrated circuits that can be configured by the user after manufacturing, making them suitable for customized hardware prototypes, a feature not available in general-purpose processors in Application Specific Integrated Circuits (ASIC). In this paper, we review the vast Machine Learning (ML) algorithms implemented on FPGAs to increase performance and capabilities in healthcare technology over 2001-2023. In particular, we focus on real-time ML algorithms targeted to FPGAs and hybrid System-on-a-chip (SoC) FPGA architectures for biomedical applications...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38416323/electrochemical-random-access-memory-recent-advances-in-materials-devices-and-systems-towards-neuromorphic-computing
#6
REVIEW
Hyunjeong Kwak, Nayeon Kim, Seonuk Jeon, Seyoung Kim, Jiyong Woo
Artificial neural networks (ANNs), inspired by the human brain's network of neurons and synapses, enable computing machines and systems to execute cognitive tasks, thus embodying artificial intelligence (AI). Since the performance of ANNs generally improves with the expansion of the network size, and also most of the computation time is spent for matrix operations, AI computation have been performed not only using the general-purpose central processing unit (CPU) but also architectures that facilitate parallel computation, such as graphic processing units (GPUs) and custom-designed application-specific integrated circuits (ASICs)...
February 28, 2024: Nano Convergence
https://read.qxmd.com/read/38359825/asics-mediate-fast-excitatory-synaptic-transmission-for-tactile-discrimination
#7
JOURNAL ARTICLE
Akihiro Yamada, Jennifer Ling, Ayaka I Yamada, Hidemasa Furue, Jianguo G Gu
Tactile discrimination, the ability to differentiate objects' physical properties such as texture, shape, and edges, is essential for environmental exploration, social interaction, and early childhood development. This ability heavily relies on Merkel cell-neurite complexes (MNCs), the tactile end-organs enriched in the fingertips of humans and the whisker hair follicles of non-primate mammals. Although recent studies have advanced our knowledge on mechanical transduction in MNCs, it remains unknown how tactile signals are encoded at MNCs...
February 6, 2024: Neuron
https://read.qxmd.com/read/38338690/opioid-analgesic-as-a-positive-allosteric-modulator-of-acid-sensing-ion-channels
#8
JOURNAL ARTICLE
Dmitry I Osmakov, Lyudmila V Onoprienko, Aleksandr P Kalinovskii, Sergey G Koshelev, Vasiliy N Stepanenko, Yaroslav A Andreev, Sergey A Kozlov
Tafalgin (Taf) is a tetrapeptide opioid used in clinical practice in Russia as an analgesic drug for subcutaneous administration as a solution (4 mg/mL; concentration of 9 mM). We found that the acid-sensing ion channels (ASICs) are another molecular target for this molecule. ASICs are proton-gated sodium channels that mediate nociception in the peripheral nervous system and contribute to fear and learning in the central nervous system. Using electrophysiological methods, we demonstrated that Taf could increase the integral current through heterologically expressed ASIC with half-maximal effective concentration values of 0...
January 24, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38329295/neuromodulation-of-acid-sensitive-ion-channels-asics-and-anti-inflammatory-potential-by-lichenxanthone-in-adult-zebrafish-danio-rerio-experimental-and-docking-studies
#9
JOURNAL ARTICLE
Hortência Ribeiro Liberato, Jéssica Bezerra Maciel, Antônio Wlisses Da Silva, Maria Eduarda Uchoa Bezerra, Luana San De Oliveira Brito, Jacilene Silva, Maria Kuerislene Amâncio Ferreira, Marcia Machado Marinho, Gabrielle S Marinho, Otília Deusdênia Loiola Pessoa, Maria Izabel F Guedes, Paulo Goberlânio De Barros Silva, Andreia Ferreira de Castro Gomes, Jane Eire Silva Alencar De Menezes, Helcio Silva Dos Santos
The xanthone Lichenxanthone did not show toxic effects (LC50 > 1.0 mg/mL). Lichenxanthone prevented nociceptive behavior induced by acidic saline, and its analgesic effect was blocked by amiloride, highlighting the involvement of neuromodulation of acid-sensitive ion channels (ASICs). In the analysis of anti-inflammatory activity, concentrations of 0.1 and 0.5 mg/mL of Lichenxanthone reduced the edema induced by k-carrageenan 3.5%, observed from the fourth hour of analysis. This effect was similar to that observed with ibuprofen (positive control)...
February 8, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38327545/avulsion-fracture-of-the-anterior-superior-iliac-crest-following-autograft-for-anterior-lumbar-fusion-case-report-and-literature-review
#10
Chao-Yuan Ge, Liang Dong, Zheng-Wei Xu, Wen-Long Yang, Li-Xiong Qian, Xiao-Wei Yang, Ding-Jun Hao
Avulsion fracture of the anterior superior iliac crest (ASIC) following autogenous bone grafting for anterior lumbar fusion (ALF) is an extremely rare complication. We describe a very rare case of avulsion fracture of the ASIC following autograft for ALF in a revision surgery for treating lumbar tuberculosis. A 68-year-old woman with lumbar tuberculosis underwent posterior debridement and posterior iliac crest bone graft fusion; however, her lumbar tuberculosis recurred 9 months after surgery. She then underwent a lumbar revision surgery, including removal of the posterior instrumentation and debridement, followed by anterior L2 corpectomy, debridement, anterior left iliac crest bone graft fusion, and internal fixation...
2024: Frontiers in Surgery
https://read.qxmd.com/read/38312021/ngf-contributes-to-activities-of-acid-sensing-ion-channels-in-dorsal-root-ganglion-neurons-of-male-rats-with-experimental-peripheral-artery-disease
#11
JOURNAL ARTICLE
Qin Li, Jianhua Li
A feature of peripheral artery diseases (PAD) includes limb ischemia/reperfusion (I/R) and ischemia. Both I/R and ischemia amplify muscle afferent nerve-activated reflex sympathetic nervous and blood pressure responses (termed as exercise pressor reflex). Nevertheless, the underlying mechanisms responsible for the exaggerated autonomic responses in PAD are undetermined. Previous studies suggest that acid-sensing ion channels (ASICs) in muscle dorsal root ganglion (DRG) play a leading role in regulating the exercise pressor reflex in PAD...
February 2024: Physiological Reports
https://read.qxmd.com/read/38310082/recent-progress-in-understanding-the-intracellular-domain-s-gating-and-functional-roles-in-trimeric-ligand-gated-ion-channels
#12
JOURNAL ARTICLE
Yan Lu, Yi Yu Lin, Jin Wang
Ligand-gated ion channels are a large category of essential ion channels, whose superfamily members may modulate their state by binding to specific ligands, allowing specific ions to pass through the cell membrane. Purinergic ligand- gated ion channel(P2X)and ASIC (acid-sensitive ion channel) are representative members of trimeric ligand-gated ion channels. Recent studies have shown that structural differences in the intracellular domain of P2X receptors (P2XR) may determine the desensitization process. The lateral fenestrations of P2XR potentially serve as a pathway for ion conduction and play a decisive role in ion selectivity...
February 2, 2024: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://read.qxmd.com/read/38290246/risk-factors-for-abdominal-surgical-infectious-complications-after-distal-gastrectomy-for-gastric-cancer-a-post-hoc-analysis-of-a-randomized-controlled-trial-jcog0912
#13
JOURNAL ARTICLE
Yusuke Taki, Seiji Ito, Junki Mizusawa, Masahiro Yura, Yuya Sato, Takashi Nomura, Masahiro Tsuda, Takeshi Omori, Chikara Kunisaki, Yasuhiro Choda, Haruhiko Cho, Naoki Hiki, Narikazu Boku, Takaki Yoshikawa, Hitoshi Katai, Masanori Terashima
BACKGROUND: Abdominal surgical infectious complications (ASIC) after gastrectomy for gastric cancer impair patients' survival and quality of life. JCOG0912 was conducted to compare laparoscopy-assisted distal gastrectomy with open distal gastrectomy for clinical stage IA or IB gastric cancer. The present study aimed to identify risk factors for ASIC using prospectively collected data. METHODS: We performed a post-hoc analysis of the risk factors for ASIC using the dataset from JCOG0912...
January 24, 2024: European Journal of Surgical Oncology
https://read.qxmd.com/read/38285576/efficient-in-vivo-neural-signal-compression-using-an-autoencoder-based-neural-network
#14
JOURNAL ARTICLE
Daniel Valencia, Patrick P Mercier, Amir Alimohammad
Conventional in vivo neural signal processing involves extracting spiking activity within the recorded signals from an ensemble of neurons and transmitting only spike counts over an adequate interval. However, for brain-computer interface (BCI) applications utilizing continuous local field potentials (LFPs) for cognitive decoding, the volume of neural data to be transmitted to a computer imposes relatively high data rate requirements. This is particularly true for BCIs employing high-density intracortical recordings with hundreds or thousands of electrodes...
January 29, 2024: IEEE Transactions on Biomedical Circuits and Systems
https://read.qxmd.com/read/38282035/molecular-determinants-of-asic1-modulation-by-divalent-cations
#15
JOURNAL ARTICLE
Yi Liu, Jichun Ma, Renee L DesJarlais, Rebecca Hagan, Jason Rech, Changlu Liu, Robyn Miller, Jeffrey Schoellerman, Jinquan Luo, Michael Letavic, Bruce Grasberger, Michael P Maher
Acid-sensing ion channels (ASICs) are proton-gated cation channels widely expressed in the nervous system. ASIC gating is modulated by divalent cations as well as small molecules; however, the molecular determinants of gating modulation by divalent cations are not well understood. Previously, we identified two small molecules that bind to ASIC1a at a novel site in the acidic pocket and modulate ASIC1 gating in a manner broadly resembling divalent cations, raising the possibility that these small molecules may help to illuminate the molecular determinants of gating modulation by divalent cations...
January 28, 2024: Scientific Reports
https://read.qxmd.com/read/38257669/thiran-filters-for-wideband-dsp-based-multi-beam-true-time-delay-rf-sensing-applications
#16
JOURNAL ARTICLE
Sirani M Perera, Gayani Rathnasekara, Arjuna Madanayake
The ability to sense propagating electromagnetic plane waves based on their directions of arrival (DOAs) is fundamental to a range of radio frequency (RF) sensing, communications, and imaging applications. This paper introduces an algorithm for the wideband true time delay digital delay Vandermonde matrix (DVM), utilizing Thiran fractional delays that are useful for realizing RF sensors having multiple look DOA support. The digital DVM algorithm leverages sparse matrix factorization to yield multiple simultaneous RF beams for low-complexity sensing applications...
January 17, 2024: Sensors
https://read.qxmd.com/read/38257502/hard-sydr-a-benchmarking-environment-for-global-navigation-satellite-system-algorithms
#17
JOURNAL ARTICLE
Antoine Grenier, Jie Lei, Hans Jakob Damsgaard, Enrique S Quintana-Ortí, Aleksandr Ometov, Elena Simona Lohan, Jari Nurmi
A Global Navigation Satellite System (GNSS) is widely used today for both positioning and timing purposes. Many distinct receiver chips are available as Application-Specific Integrated Circuit (ASIC)s off-the-shelf, each tailored to the requirements of various applications. These chips deliver good performance and low energy consumption but offer customers little-to-no transparency about their internal features. This prevents modification, research in GNSS processing chain enhancement (e.g., application of Approximate Computing (AxC) techniques), and design space exploration to find the optimal receiver for a use case...
January 9, 2024: Sensors
https://read.qxmd.com/read/38227403/neurobus-architecture-for-an-ultra-flexible-neural-interface
#18
JOURNAL ARTICLE
Markus Sporer, Ioana-Georgiana Vasilas, Ahmed Adzemovic, Nicolas Graber, Stefan Reich, Calogero Gueli, Max Eickenscheidt, Ilka Diester, Thomas Stieglitz, Maurits Ortmanns
This paper presents the system architecture for an implant concept called NeuroBus. Tiny distributed direct digitizing neural recorder ASICs on an ultra-flexible polyimide substrate are connected in a bus-like structure, allowing short connections between electrode and recording front-end with low wiring effort and high customizability. The small size (344 μm x 294 μm) of the ASICs and the ultraflexible substrate allow a low bending stiffness, enabling the implant to adapt to the curvature of the brain and achieving high structural biocompatibility...
January 16, 2024: IEEE Transactions on Biomedical Circuits and Systems
https://read.qxmd.com/read/38221631/mechanosensitive-receptors-in-migraine-a-systematic-review
#19
REVIEW
Adriana Della Pietra, Laura Gómez Dabó, Petr Mikulenka, Christian Espinoza-Vinces, Doga Vuralli, Isil Baytekin, Paolo Martelletti, Rashid Giniatullin
BACKGROUND: Migraine is a debilitating neurological disorder with pain profile, suggesting exaggerated mechanosensation. Mechanosensitive receptors of different families, which specifically respond to various mechanical stimuli, have gathered increasing attention due to their potential role in migraine related nociception. Understanding these mechanisms is of principal importance for improved therapeutic strategies. This systematic review comprehensively examines the involvement of mechanosensitive mechanisms in migraine pain pathways...
January 15, 2024: Journal of Headache and Pain
https://read.qxmd.com/read/38215949/an-electrode-impedance-aware-neurostimulator-ic-that-achieves-low-power-consumption-and-fast-charge-balance
#20
JOURNAL ARTICLE
Yawen Shi, Quanbei Chang, Xiao Liu
Implantable neural stimulation is becoming increasingly popular for treating neurologically impaired patients, restoring neural functions which would otherwise be lost due to diseases or injuries. The charge balance of the stimulus pulses is of paramount importance for the long-term safety of the electrode-tissue interface. This paper presents a novel neurostimulator integrated circuit in which two novel charge balancing schemes are proposed. One is based on acquiring the access resistance part (RS ) of the inter-electrode impedance...
January 10, 2024: Journal of Neuroscience Methods
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