Hortência Ribeiro Liberato, Jéssica Bezerra Maciel, Antônio Wlisses Da Silva, Maria Eduarda Uchoa Bezerra, Luana San De Oliveira Brito, Jacilene Silva, Maria Kuerislene Amâncio Ferreira, Marcia Machado Marinho, Gabrielle S Marinho, Otília Deusdênia Loiola Pessoa, Maria Izabel F Guedes, Paulo Goberlânio De Barros Silva, Andreia Ferreira de Castro Gomes, Jane Eire Silva Alencar De Menezes, Helcio Silva Dos Santos
The xanthone Lichenxanthone did not show toxic effects (LC50 > 1.0 mg/mL). Lichenxanthone prevented nociceptive behavior induced by acidic saline, and its analgesic effect was blocked by amiloride, highlighting the involvement of neuromodulation of acid-sensitive ion channels (ASICs). In the analysis of anti-inflammatory activity, concentrations of 0.1 and 0.5 mg/mL of Lichenxanthone reduced the edema induced by k-carrageenan 3.5%, observed from the fourth hour of analysis. This effect was similar to that observed with ibuprofen (positive control)...
February 8, 2024: Chemistry & Biodiversity