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Lipid membrane interactions neurons

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https://www.readbyqxmd.com/read/27884599/influence-of-sequence-and-lipid-type-on-membrane-perturbation-by-human-and-rat-amyloid-%C3%AE-peptide-1-42
#1
Anne M Brown, David R Bevan
The hallmark characteristics of plaque formation and neuronal cell death in Alzheimer's disease (AD) are caused principally by the amyloid β-peptide (Aβ). Aβ sequence and lipid composition are essential variables to consider when elucidating the impact of biological membranes on Aβ structure and the effect of Aβ on membrane integrity. Atomistic molecular dynamics simulations testing two Aβ sequences, human and rat Aβ (HAβ and RAβ, respectively), and five lipid types were performed to assess the effect of these variables on membrane perturbation and potential link to AD phenotype differences based on differences in sequence...
November 21, 2016: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/27871938/the-role-of-gpi-anchored-axonal-glycoproteins-in-neural-development-and-neurological-disorders
#2
REVIEW
Gianfranco Gennarini, Antonella Bizzoca, Sabrina Picocci, Daniela Puzzo, Patrizia Corsi, Andrew J W Furley
This review article focuses on the Contactin (CNTN) subset of the Immunoglobulin supergene family (IgC2/FNIII molecules), whose components share structural properties (the association of Immunoglobulin type C2 with Fibronectin type III domains), as well as a general role in cell contact formation and axonal growth control. IgC2/FNIII molecules include 6 highly related components (CNTN 1-6), associated with the cell membrane via a Glycosyl Phosphatidyl Inositol (GPI)-containing lipid tail. Contactin 1 and Contactin 2 share ~50 (49...
November 18, 2016: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/27814578/lipid-raft-er-signalosome-malfunctions-in-menopause-and-alzheimer-s-disease
#3
Ana Canerina-Amaro, Luis G Hernandez-Abad, Isidre Ferrer, David Quinto-Alemany, Fatima Mesa-Herrera, Carla Ferri, Ricardo A Puertas-Avendano, Mario Diaz, Raquel Marin
The increase in the incidence of Alzheimer's disease (AD) in old women may be attributable to estrogen deficiency, and estrogen replacement therapy may be useful in preventing or delaying the onset of this disease. In neuronal membranes, 17 beta-estradiol interacts with estrogen receptors (mERs) located in lipid raft signalosomes which trigger neuroprotective responses by anchoring to scaffolding caveolin-1 complexed with other proteins. We suggest that mER-signalosome malfunctions in AD and by menopause due to development of aberrations in these microstructures...
January 1, 2017: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/27728769/real-time-quartz-crystal-microbalance-monitoring-of-free-docosahexaenoic-acid-interactions-with-supported-lipid-bilayers
#4
Kiera R Flynn, Lisandra L Martin, M Leigh Ackland, Angel A J Torriero
Docosahexaenoic acid (DHA) is the most abundant polyunsaturated omega-3 fatty acid found in mammalian neuronal cell membranes. Although DHA is known to be important for neuronal cell survival, little is know about how DHA interacts with phospholipid bilayers. This study presents a detailed quartz crystal microbalance with dissipation monitoring (QCM-D) analysis of free DHA interactions with individual and mixed phospholipid supported lipid bilayers (SLB). DHA incorporation and subsequent changes to the SLBs viscoelastic properties were observed to be concentration-dependent, influenced by the phospholipid species, the headgroup charge, and the presence or absence of calcium ions...
November 1, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27713956/lipidomic-approach-in-young-adult-triathletes-effect-of-supplementation-with-a-polyphenols-rich-juice-on-neuroprostane-and-f2-dihomo-isoprostane-markers
#5
Libia Alejandra García-Flores, Sonia Medina, Camille Oger, Jean-Marie Galano, Thierry Durand, Roberto Cejuela, José Miguel Martínez-Sanz, Federico Ferreres, Ángel Gil-Izquierdo
The aim of the this study was to determine the effect of a polyphenols-rich juice (aronia-citrus juice, ACJ) on F4-neuroprostanes and F2-dihomo-isoprostanes-markers of oxidative stress associated with the central nervous system (CNS)-in 16 elite triathletes under a controlled diet for triathlon training (145 days). In the triathletes, a decrease of the lipid peroxidation markers after ACJ intake, associated with neuronal membrane degradation (10-epi-10-F4t-neuroprostane and 10-F4t-neuroprostane), was observed when compared with placebo stage values...
October 12, 2016: Food & Function
https://www.readbyqxmd.com/read/27694812/a-plasma-membrane-microdomain-compartmentalizes-ephrin-generated-camp-signals-to-prune-developing-retinal-axon-arbors
#6
Stefania Averaimo, Ahlem Assali, Oriol Ros, Sandrine Couvet, Yvrick Zagar, Ioana Genescu, Alexandra Rebsam, Xavier Nicol
The development of neuronal circuits is controlled by guidance molecules that are hypothesized to interact with the cholesterol-enriched domains of the plasma membrane termed lipid rafts. Whether such domains enable local intracellular signalling at the submicrometre scale in developing neurons and are required for shaping the nervous system connectivity in vivo remains controversial. Here, we report a role for lipid rafts in generating domains of local cAMP signalling in axonal growth cones downstream of ephrin-A repulsive guidance cues...
October 3, 2016: Nature Communications
https://www.readbyqxmd.com/read/27641118/a-novel-approach-for-targeted-delivery-to-motoneurons-using-cholera-toxin-b-modified-protocells
#7
Maria A Gonzalez Porras, Paul N Durfee, Ashley M Gregory, Gary C Sieck, C Jeffrey Brinker, Carlos B Mantilla
BACKGROUND: Trophic interactions between muscle fibers and motoneurons at the neuromuscular junction (NMJ) play a critical role in determining motor function throughout development, aging, injury, or disease. Treatment of neuromuscular disorders is hindered by the inability to selectively target motoneurons with pharmacological and genetic interventions. NEW METHOD: We describe a novel delivery system to motoneurons using mesoporous silica nanoparticles encapsulated within a lipid bilayer (protocells) and modified with the atoxic subunit B of the cholera toxin (CTB) that binds to gangliosides present on neuronal membranes...
September 15, 2016: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/27610460/ganglioside-lipid-and-ganglioside-protein-interactions-revealed-by-coarse-grained-and-atomistic-molecular-dynamics-simulations
#8
Ruo-Xu Gu, Helgi I Ingólfsson, Alex H de Vries, Siewert J Marrink, D Peter Tieleman
Gangliosides are glycolipids in which an oligosaccharide headgroup containing one or more sialic acids is connected to a ceramide. Gangliosides reside in the outer leaflet of the plasma membrane and play a crucial role in various physiological processes such as cell signal transduction and neuronal differentiation by modulating structures and functions of membrane proteins. Because the detailed behavior of gangliosides and protein-ganglioside interactions are poorly known, we investigated the interactions between the gangliosides GM1 and GM3 and the proteins aquaporin (AQP1) and WALP23 using equilibrium molecular dynamics simulations and potential of mean force calculations at both coarse-grained (CG) and atomistic levels...
October 4, 2016: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/27605302/site-specific-fluorescent-labeling-to-visualize-membrane-translocation-of-a-myristoyl-switch-protein
#9
Sung-Tae Yang, Sung In Lim, Volker Kiessling, Inchan Kwon, Lukas K Tamm
Fluorescence approaches have been widely used for elucidating the dynamics of protein-membrane interactions in cells and model systems. However, non-specific multi-site fluorescent labeling often results in a loss of native structure and function, and single cysteine labeling is not feasible when native cysteines are required to support a protein's folding or catalytic activity. Here, we develop a method using genetic incorporation of non-natural amino acids and bio-orthogonal chemistry to site-specifically label with a single fluorescent small molecule or protein the myristoyl-switch protein recoverin, which is involved in rhodopsin-mediated signaling in mammalian visual sensory neurons...
September 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27596061/effects-of-membrane-properties-on-the-binding-activities-of-the-hn-and-hc-heavy-chain-domains-of-botulinum-neurotoxin-a
#10
B Vijayalakshmi Ayyar, M Zouhair Atassi
Binding behaviors of the HN and the HC domains of BoNT/A were investigated individually to identify if there exist any differences in their interaction with the cell membrane. Recombinant fragments corresponding to both BoNT/A HN and HC regions were prepared (HN519-845 and HC967-1296) and their binding to synaptic proteins was verified. The binding behaviors of these heavy-chain domains were analyzed by treating the Neuro 2a, a murine neuroblastoma cell line, with compounds known to alter membrane properties...
December 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27565678/membrane-fluidity-does-not-explain-how-solvents-act-on-the-middle-ear-reflex
#11
Ludivine Wathier, Thomas Venet, Aurélie Thomas, Hervé Nunge, Elodie Bonfanti, Frédéric Cosnier, Cécile Parietti-Winkler, Pierre Campo, Pascale Tsan, Sabine Bouguet-Bonnet, Axel Gansmüller
Some volatile aromatic solvents have similar or opposite effects to anesthetics in the central nervous system. Like for anesthetics, the mechanisms of action involved are currently the subject of debate. This paper presents an in vivo study to determine whether direct binding or effects on membrane fluidity best explain how solvents counterbalance anesthesia's depression of the middle-ear reflex (MER). Rats were anesthetized with a mixture of ketamine and xylazine while also exposed to solvent vapors (toluene, ethylbenzene, or one of the three xylene isomers) and the amplitude of their MER was monitored...
August 24, 2016: Neurotoxicology
https://www.readbyqxmd.com/read/27489575/the-initiation-of-post-synaptic-protrusions
#12
Pirta Hotulainen, Juha Saarikangas
The post-synaptic spines of neuronal dendrites are highly elaborate membrane protrusions. Their anatomy, stability and density are intimately linked to cognitive performance. The morphological transitions of spines are powered by coordinated polymerization of actin filaments against the plasma membrane, but how the membrane-associated polymerization is spatially and temporally regulated has remained ill defined. Here, we discuss our recent findings showing that dendritic spines can be initiated by direct membrane bending by the I-BAR protein MIM/Mtss1...
May 2016: Communicative & Integrative Biology
https://www.readbyqxmd.com/read/27459095/multiscale-simulations-suggest-a-mechanism-for-the-association-of-the-dok7-ph-domain-with-pip-containing-membranes
#13
Amanda Buyan, Antreas C Kalli, Mark S P Sansom
Dok7 is a peripheral membrane protein that is associated with the MuSK receptor tyrosine kinase. Formation of the Dok7/MuSK/membrane complex is required for the activation of MuSK. This is a key step in the complex exchange of signals between neuron and muscle, which lead to neuromuscular junction formation, dysfunction of which is associated with congenital myasthenic syndromes. The Dok7 structure consists of a Pleckstrin Homology (PH) domain and a Phosphotyrosine Binding (PTB) domain. The mechanism of the Dok7 association with the membrane remains largely unknown...
July 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27453199/cholesterol-dependent-thermotropic-behavior-and-organization-of-neuronal-membranes
#14
S Thirupathi Reddy, Sandeep Shrivastava, K Mallesham, Amitabha Chattopadhyay
The composition of neuronal membranes is unique with diverse lipid composition due to evolutionary requirement. The organization and dynamics of neuronal membranes are crucial for efficient functioning of neuronal receptors. We have previously established hippocampal membranes as a convenient natural source for exploring lipid-protein interactions, and organization of neuronal receptors. Keeping in mind the pathophysiological role of neuronal cholesterol, in this work, we used differential scanning calorimetry (DSC) and small angle X-ray scattering (SAXS) to explore thermotropic phase behavior and organization (thickness) of hippocampal membranes under conditions of varying cholesterol content...
November 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27449929/mitochondrial-lipids-in-neurodegeneration
#15
Andreas Aufschnaiter, Verena Kohler, Jutta Diessl, Carlotta Peselj, Didac Carmona-Gutierrez, Walter Keller, Sabrina Büttner
Mitochondrial dysfunction is a common feature of many neurodegenerative diseases, including proteinopathies such as Alzheimer's or Parkinson's disease, which are characterized by the deposition of aggregated proteins in the form of insoluble fibrils or plaques. The distinct molecular processes that eventually result in mitochondrial dysfunction during neurodegeneration are well studied but still not fully understood. However, defects in mitochondrial fission and fusion, mitophagy, oxidative phosphorylation and mitochondrial bioenergetics have been linked to cellular demise...
July 23, 2016: Cell and Tissue Research
https://www.readbyqxmd.com/read/27359048/graphene-oxide-nanosheets-disrupt-lipid-composition-ca-2-homeostasis-and-synaptic-transmission-in-primary-cortical-neurons
#16
Mattia Bramini, Silvio Sacchetti, Andrea Armirotti, Anna Rocchi, Ester Vázquez, Verónica León Castellanos, Tiziano Bandiera, Fabrizia Cesca, Fabio Benfenati
Graphene has the potential to make a very significant impact on society, with important applications in the biomedical field. The possibility to engineer graphene-based medical devices at the neuronal interface is of particular interest, making it imperative to determine the biocompatibility of graphene materials with neuronal cells. Here we conducted a comprehensive analysis of the effects of chronic and acute exposure of rat primary cortical neurons to few-layer pristine graphene (GR) and monolayer graphene oxide (GO) flakes...
July 26, 2016: ACS Nano
https://www.readbyqxmd.com/read/27324899/the-neuron-specific-protein-tmem59l-mediates-oxidative-stress-induced-cell-death
#17
Qiuyang Zheng, Xiaoyuan Zheng, Lishan Zhang, Hong Luo, Lingzhi Qian, Xing Fu, Yiqian Liu, Yuehong Gao, Mengxi Niu, Jian Meng, Muxian Zhang, Guojun Bu, Huaxi Xu, Yun-Wu Zhang
TMEM59L is a newly identified brain-specific membrane-anchored protein with unknown functions. Herein we found that both TMEM59L and its homolog, TMEM59, are localized in Golgi and endosomes. However, in contrast to a ubiquitous and relatively stable temporal expression of TMEM59, TMEM59L expression was limited in neurons and increased during development. We also found that both TMEM59L and TMEM59 interacted with ATG5 and ATG16L1, and that overexpression of them triggered cell autophagy. However, overexpression of TMEM59L induced intrinsic caspase-dependent apoptosis more dramatically than TMEM59...
June 21, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27302750/a-cd36-ectodomain-mediates-insect-pheromone-detection-via-a-putative-tunnelling-mechanism
#18
Carolina Gomez-Diaz, Benoîte Bargeton, Liliane Abuin, Natalia Bukar, Jaime H Reina, Tudor Bartoi, Marion Graf, Huy Ong, Maximilian H Ulbrich, Jean-Francois Masson, Richard Benton
CD36 transmembrane proteins have diverse roles in lipid uptake, cell adhesion and pathogen sensing. Despite numerous in vitro studies, how they act in native cellular contexts is poorly understood. A Drosophila CD36 homologue, sensory neuron membrane protein 1 (SNMP1), was previously shown to facilitate detection of lipid-derived pheromones by their cognate receptors in olfactory cilia. Here we investigate how SNMP1 functions in vivo. Structure-activity dissection demonstrates that SNMP1's ectodomain is essential, but intracellular and transmembrane domains dispensable, for cilia localization and pheromone-evoked responses...
2016: Nature Communications
https://www.readbyqxmd.com/read/27282693/biophysical-insights-into-the-membrane-interaction-of-the-core-amyloid-forming-a%C3%AE-40-fragment-k16-k28-and-its-role-in-the-pathogenesis-of-alzheimer-s-disease
#19
Swapna Bera, Kyle J Korshavn, Rajiv K Kar, Mi Hee Lim, Ayyalusamy Ramamoorthy, Anirban Bhunia
The aggregation of amyloid-β (Aβ) on neuronal membranes is implicated in both neuronal toxicity and the progression of Alzheimer's disease. Unfortunately, the heterogeneous environment that results from peptide aggregation in the presence of lipids makes the details of these pathways difficult to interrogate. In this study, we report an investigation of the membrane interaction of an Aβ fragment (K16LVFFAEDVGSNK28, KK13), which maintains the amyloidogenic nature of the full-length peptide and is implicated in membrane-mediated folding, through a combination of NMR spectroscopy and molecular dynamics simulations...
June 22, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27276266/the-functional-activity-of-the-human-serotonin-5-ht1a-receptor-is-controlled-by-lipid-bilayer-composition
#20
M Gertrude Gutierrez, Kylee S Mansfield, Noah Malmstadt
Although the properties of the cell plasma membrane lipid bilayer are broadly understood to affect integral membrane proteins, details of these interactions are poorly understood. This is particularly the case for the large family of G protein-coupled receptors (GPCRs). Here, we examine the lipid dependence of the human serotonin 5-HT1A receptor, a GPCR that is central to neuronal function. We incorporate the protein in synthetic bilayers of controlled composition together with a fluorescent reporting system that detects GPCR-catalyzed activation of G protein to measure receptor-catalyzed oligonucleotide exchange...
June 7, 2016: Biophysical Journal
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