M Röhrich, J J Rosales, J Hoppner, P Kvacskay, N Blank, L Loi, D Paech, M Schreckenberger, F Giesel, H U Kauczor, H M Lorenz, U Haberkorn, W Merkt
OBJECTIVES: Epigenetically modified fibroblasts contribute to chronicity in inflammatory diseases. Reasons for the relapsing character of large vessel vasculitis (LVV) remain obscure, including the role of fibroblasts, in part due to limited access to biopsies of involved tissue.68Ga FAPI-46 (FAPI)-PET/CT detects activated fibroblasts in vivo. In this exploratory pilot study, we tested the detection of fibroblast activation in vessel walls using FAPI-PET/CT in LVV with aortitis. METHODS: 8 LVV patients with aortitis and 8 age- and gender-matched controls were included...
April 22, 2024: Rheumatology