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https://www.readbyqxmd.com/read/29775752/the-genetics-and-molecular-pathogenesis-of-systemic-lupus-erythematosus-sle-in-populations-of-different-ancestry
#1
REVIEW
George N Goulielmos, Maria I Zervou, Vassilis M Vazgiourakis, Yogita Ghodke-Puranik, Alexandros Garyfallos, Timothy B Niewold
Systemic lupus erythematosus (SLE; OMIM 152700) is a highly heterogeneous disorder, characterized by differences in autoantibody profile, serum cytokines, and a multi-system involvement commonly affecting the skin, renal, musculoskeletal, and hematopoetic systems clinical manifestations involving. Disease features range from mild manifestations, such as rash or arthritis, to life-threatening end-organ manifestations, such as glomerulonephritis or thrombosis, and it is difficult to predict which manifestations will affect a given patient...
May 15, 2018: Gene
https://www.readbyqxmd.com/read/29775673/gender-dependent-contribution-of-muscarinic-receptors-in-memory-retrieval-under-sub-chronic-stress
#2
Habiba Rashid, Touqeer Ahmed
Stress induces retrograde amnesia in humans and rodents. Muscarinic antagonism under normal physiological conditions causes gender dependent impairment in episodic memory retrieval. We aimed to explore the gender dependent role of muscarinic receptors in memory retrieval under sub-chronic stress condition. Male and female mice were trained for Morris water maze test and contextual fear conditioning, followed by 3 hour restraint stress per day for five days. Stress was either given alone or in combination with a daily subcutaneous injection of scopolamine (1 mg/kg) or donepezil (1 mg/kg)...
May 15, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29775109/outcomes-of-surgery-as-part-of-the-management-of-metastatic-non-small-cell-lung-cancer-a-surveillance-epidemiology-and-end-results-database-analysis
#3
Omar Abdel-Rahman
The role of local treatment in patients with oligometastatic non-small-cell lung cancer (NSCLC) is a subject of ongoing debate. This study assessed the survival impact of combined surgery to the primary tumor and metastatic disease in the management of metastatic NSCLC. Stage IV NSCLC patients at presentation, diagnosed from 2004 to 2013 were identified from the SEER (Surveillance, Epidemiology, and End Results) database. Propensity-matched analysis was performed considering baseline characteristics (age, gender, race, histology, TN stage, and site of metastases)...
April 21, 2018: Cancer Investigation
https://www.readbyqxmd.com/read/29774989/first-report-of-wild-boar-susceptibility-to-porcine-circovirus-type-3-high-prevalence-in-the-colli-euganei-regional-park-italy-in-the-absence-of-clinical-signs
#4
Giovanni Franzo, Claudia Maria Tucciarone, Michele Drigo, Mattia Cecchinato, Marco Martini, Alessandra Mondin, Maria Luisa Menandro
The genus Circovirus includes one of the most relevant infectious agents affecting domestic pigs, Porcine circovirus type 2 (PCV-2). The wild boar susceptibility to this pathogen has also been demonstrated although the actual epidemiological role of wild populations is still debated. In recent times, a new circovirus, Porcine circovirus type 3 (PCV-3), has been discovered and reported in the presence of several clinical conditions. However, no information is currently available about PCV-3 circulation and prevalence in wild boar...
May 18, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29774528/slc40a1-and-cp-single-nucleotide-polymorphisms-in-porphyria-cutanea-tarda-patients-of-mixed-ancestry
#5
Isabella Brasil Succi, Luís Cristóvão Pôrto, Dayse Silva, Adriana Nascimento, Ronald Costa Neto, João Carlos Fonseca
Porphyria cutanea tarda (PCT) is a multifactorial disease; clinical expression depends on both genetic and acquired factors. Few studies have examined the connection between PCT and the regulation of iron metabolism genes other than the HFE gene. We selected five polymorphisms in the CYBRD1, CP, SLC40A1, and HAMP genes to determine whether these polymorphisms can act as genetic modulators in patients with sporadic PCT. None of the 29 patients carried the C282Y mutation. Genomic DNA from 29 PCT patients was isolated...
May 17, 2018: Annals of Human Genetics
https://www.readbyqxmd.com/read/29774007/the-influence-of-sexual-orientation-on-the-perceived-fit-of-male-applicants-for-both-male-and-female-typed-jobs
#6
Heather M Clarke, Kara A Arnold
Research demonstrates the bias faced by individuals engaged in occupations that are perceived as inconsistent with their gender. The lack of fit model and role congruity theory explain how gender stereotypes give rise to the perception that an individual lacks the attributes necessary to be successful in a gender-incongruent job. Men employed in jobs traditionally held by women are perceived as wimpy and undeserving of respect. The majority of studies in this area have, however, failed to account for the sexual orientation of the individual being rated...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29773828/single-nucleotide-polymorphisms-in-the-g-protein-coupled-receptor-kinase-5-grk5-gene-are-associated-with-plasma-ldl-cholesterol-levels-in-humans
#7
Stefan Z Lutz, Mathias Falcenberg, Fausto Machicao, Andreas Peter, Martin Kächele, Elko Randrianarisoa, Angela Lehn-Stefan, Robert Wagner, Jürgen Machann, Fritz Schick, Martin Heni, Axel Ullrich, Andreas Fritsche, Norbert Stefan, Hans-Ulrich Häring, Harald Staiger, Konstantinos Kantartzis
Genetically modified mice models suggest an important role for G-protein-coupled receptor kinase 5 (GRK5) in the pathophysiology of obesity and related disorders. We investigated whether single nucleotide polymorphisms (SNPs) in the gene encoding GRK5 affect cardiometabolic traits in humans. We genotyped 3 common SNPs in intron 1 (rs1980030, rs10466210, rs9325562) and one SNP in intron 3 (rs10886471) of GRK5 in 2332 subjects at risk for type 2 diabetes. Total- and visceral fat mass were measured by magnetic resonance (MR) tomography and liver fat content by 1 H-MR spectroscopy...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29772990/the-effects-of-meniscal-geometry-on-susceptibility-for-meniscal-and-acl-injury-in-non-arthritic-knees-a-retrospective-case-control-study
#8
Alexander Tejani, Qais Naziri, Preston W Grieco, Robert Pivec, Damon Greene, Bhaveen V Kapadia, Dipal Chatterjee, William P Urban
Prior studies have not found significant differences in meniscal parameters between patients with meniscal and ligamentous injury and those without. The purpose of this study was to determine whether such relationships exist. Clinical records and magnetic resonance images of three subject groups were reviewed. Group 1 solely had meniscal tears (medial/lateral), Group 2 had meniscal tears with concurrent ACL tears, and Group 3 had healthy knees. The mean age of subjects included was 35.9 years (range 8.2-72...
2018: Journal of Long-term Effects of Medical Implants
https://www.readbyqxmd.com/read/29772912/relations-between-empathy-and-anxiety-dimensions-in-inpatient-adolescents
#9
Malgorzata Gambin, Carla Sharp
BACKGROUND AND OBJECTIVES: A better understanding of the relationships between empathy and internalizing disorders is needed to plan therapeutic interventions for children and adolescents. Several studies have revealed positive relations of internalizing symptoms to personal distress and affective empathy. However, there is a lack of studies that take into account the multidimensional nature of anxiety in its relation to empathy. DESIGN: Structural equation modeling was used to test the moderated mediation model of the relations between empathy, depression and anxiety dimensions and the moderating role of gender on these associations in inpatient adolescents...
May 17, 2018: Anxiety, Stress, and Coping
https://www.readbyqxmd.com/read/29772765/protein-carbamylation-a-marker-reflecting-increased-age-related-cell-oxidation
#10
Julia Carracedo, Rafael Ramírez-Carracedo, Irene Martínez de Toda, Carmen Vida, Matilde Alique, Mónica De la Fuente, Rafael Ramírez-Chamond
Carbamylation is a post-translational modification of proteins that may partake in the oxidative stress-associated cell damage, and its increment has been recently proposed as a "hallmark of aging". The molecular mechanisms associated with aging are related to an increased release of free radicals. We have studied whether carbamylated proteins from the peripheral blood of healthy subjects are related to oxidative damage and aging, taking into account the gender and the immune profile of the subjects...
May 17, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29772240/identification-and-characterization-of-the-zinc-finger-protein-sjzf-in-schistosoma-japonicum
#11
Ruixiang Zhang, Jian Li, Manyu Xiang, Qinghua Hong, Bin Xu, Wei Hu
Schistosomiasis represents one of the most prevalent parasitic infections affecting over 249 million people worldwide. The pathological damage is mainly caused by the eggs laid by female schistosomes. Zinc finger proteins (ZFPs) usually play critical roles in many biological functions. In this study, we cloned, identified and characterized the zinc finger protein SjZF of Schistosoma japonicum. SjZF ortholog proteins were also identified in S. mansoni, S. haematobium, Opisthorchis viverrini and O. sinensis. Fluorescence localization showed that SjZF was particularly expressed in the worm gut of both genders and the vitelline glands of females...
May 14, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29772106/the-relationships-between-pain-catastrophizing-subcomponents-and-multiple-pain-related-outcomes-in-japanese-outpatients-with-chronic-pain-a-cross-sectional-study
#12
Tomonori Adachi, Aya Nakae, Tomoyuki Maruo, Kenrin Shi, Lynn Maeda, Youichi Saitoh, Masahiko Shibata, Jun Sasaki
OBJECTIVES: The present study sought to examine associations between the pain catastrophizing subcomponents and multiple pain-related outcomes in Japanese individuals with chronic pain. METHODS: A cross-sectional study design was employed with 213 chronic pain outpatients. The participants were recruited from three units at one university hospital and from a pain clinic at a municipal hospital. Study measures were used to assess pain catastrophizing, anxiety, depression, pain interference, and pain severity...
May 17, 2018: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29771947/academic-information-on-twitter-a-user-survey
#13
Ehsan Mohammadi, Mike Thelwall, Mary Kwasny, Kristi L Holmes
Although counts of tweets citing academic papers are used as an informal indicator of interest, little is known about who tweets academic papers and who uses Twitter to find scholarly information. Without knowing this, it is difficult to draw useful conclusions from a publication being frequently tweeted. This study surveyed 1,912 users that have tweeted journal articles to ask about their scholarly-related Twitter uses. Almost half of the respondents (45%) did not work in academia, despite the sample probably being biased towards academics...
2018: PloS One
https://www.readbyqxmd.com/read/29770913/diagnostic-value-of-myocardial-deformation-pattern-in-children-with-noncompaction-cardiomyopathy
#14
Putri Yubbu, Hythem M Nawaytou, Renzo Calderon-Anyosa, Anirban Banerjee
The current echocardiographic diagnostic criteria for noncompaction cardiomyopathy (NCC) have variable sensitivity and low specificity. Moreover, there are limited data on the use of myocardial deformation imaging for early detection of myocardial dysfunction in children with NCC. We describe left ventricular (LV) deformation patterns in children with NCC, with the goal of identifying a potential diagnostic pattern. We prospectively enrolled 30 children with NCC (47% male; mean age 7.2 years) and 30 age- and gender-matched controls...
May 16, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29770113/aggression-in-women-behavior-brain-and-hormones
#15
REVIEW
Thomas F Denson, Siobhan M O'Dean, Khandis R Blake, Joanne R Beames
We review the literature on aggression in women with an emphasis on laboratory experimentation and hormonal and brain mechanisms. Women tend to engage in more indirect forms of aggression (e.g., spreading rumors) than other types of aggression. In laboratory studies, women are less aggressive than men, but provocation attenuates this difference. In the real world, women are just as likely to aggress against their romantic partner as men are, but men cause more serious physical and psychological harm. A very small minority of women are also sexually violent...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29768945/pharmacist-impact-on-treatment-intensification-and-hemoglobin-a-1c-in-patients-with-type-2-diabetes-mellitus-at-an-academic-health-center
#16
Kevin Cowart, Karen Sando
BACKGROUND: Achievement of treatment goals for patients with type 2 diabetes mellitus (T2DM) is suboptimal. This is in part driven by a lack of treatment intensification when warranted, termed "clinical inertia." OBJECTIVES: To investigate time to treatment intensification and changes in A1C among pharmacist-physician managed (PPM) patients compared to usual medical care (UMC) in patients with T2DM. METHODS: Retrospective matched cohort study at 2 academic family medicine clinics...
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29768926/the-influence-of-friends-and-psychosocial-factors-on-physical-activity-and-screen-time-in-normal-and-overweight-adolescents-a-mixed-methods-analysis
#17
Jeanette M Garcia, John R Sirard, Diane E Whaley, David J Rice, Kayla Baker, Arthur Weltman
BACKGROUND: Understanding factors that influence physical activity (PA) and sedentary behavior is crucial to develop interventions to improve adolescents' health-related behaviors. PURPOSE: To compare the influence of friends and psychosocial factors on moderate-to-vigorous physical activity (MVPA) and screen time (ST) between normal weight (NW) and overweight (OW) adolescents. METHODS: In all, 21 OW and 21 NW adolescents wore accelerometers and completed questionnaires assessing MVPA, ST, and psychosocial variables...
January 1, 2018: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/29768447/the-role-of-social-relationships-in-the-link-between-olfactory-dysfunction-and-mortality
#18
Carrianne J Leschak, Naomi I Eisenberger
Recent work suggests that olfactory dysfunction is a strong predictor of five-year mortality in older adults. Based on past work showing: 1) that olfactory dysfunction impairs social functioning and 2) that social ties are linked with mortality, the current work explored whether impairments in social life mediated the relationship between olfactory dysfunction and mortality. Additionally, based on work showing gender differences in the social consequences of olfactory dysfunction, gender was assessed as a potential moderator of this association...
2018: PloS One
https://www.readbyqxmd.com/read/29767908/gender-differences-in-body-mass-index-body-weight-perception-weight-satisfaction-disordered-eating-and-weight-control-strategies-among-indian-medical-and-nursing-undergraduates
#19
Poreddi Vijayalakshmi, Rohini Thimmaiah, S Sai Nikhil Reddy, Kathyayani B V, Sailaxmi Gandhi, Suresh BadaMath
OBJECTIVES: To assess gender disparity in body weight perception, Body Mass Index (BMI), weight satisfaction and role of depression among undergraduate Medical and Nursing students. METHODS: A descriptive cross sectional descriptive study was conducted in conveniently selected medical (n=241) and nursing (n=213) students of Bangalore, South India. Data was collected using self-administered SCOFF questionnaires. RESULTS: Our findings revealed that men had a significantly higher BMI than women (t=5...
October 2017: Investigación y Educación en Enfermería
https://www.readbyqxmd.com/read/29767281/hiv-risk-among-displaced-adolescent-girls-in-ethiopia-the-role-of-gender-attitudes-and-self-esteem
#20
Laura Gauer Bermudez, Gary Yu, Lily Lu, Kathryn Falb, Jennate Eoomkham, Gizman Abdella, Lindsay Stark
Adolescent girls in sub-Saharan Africa have been deemed one of the most critical populations to address in the campaign for an HIV-free generation. Experiences of intimate partner violence (IPV), harmful gender norms, diminished personal agency, and age-disparate sex have been identified as factors in the increasing rate of new infections among this population. Using baseline data from a cluster-randomized controlled trial in three refugee camps in Benishangul-Gumuz Regional State in Ethiopia, our study quantitatively examined the associations between HIV risk factors, attitudes on gender inequality, IPV acceptability, and self-esteem for female adolescent refugees primarily from Sudan and South Sudan (n = 919)...
May 16, 2018: Prevention Science: the Official Journal of the Society for Prevention Research
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