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https://www.readbyqxmd.com/read/28107386/regulation-of-pi-2b-pilus-expression-in-hypervirulent-streptococcus-agalactiae-st-17-bm110
#1
Bruno Périchon, Noémi Szili, Laurence du Merle, Isabelle Rosinski-Chupin, Myriam Gominet, Samuel Bellais, Claire Poyart, Patrick Trieu-Cuot, Shaynoor Dramsi
The widely spread Streptococcus agalactiae (also known as Group B Streptococcus, GBS) "hypervirulent" ST17 clone is strongly associated with neonatal meningitis. The PI-2b locus is mainly found in ST17 strains but is also present in a few non ST17 human isolates such as the ST-7 prototype strain A909. Here, we analysed the expression of the PI-2b pilus in the ST17 strain BM110 as compared to the non ST17 A909. Comparative genome analyses revealed the presence of a 43-base pair (bp) hairpin-like structure in the upstream region of PI-2b operon in all 26 ST17 genomes, which was absent in the 8 non-ST17 strains carrying the PI-2b locus...
2017: PloS One
https://www.readbyqxmd.com/read/28107374/combining-social-norms-and-social-marketing-to-address-underage-drinking-development-and-process-evaluation-of-a-whole-of-community-intervention
#2
Sandra C Jones, Kelly Andrews, Kate Francis
Youth alcohol consumption has been steadily declining in Australia, as in other countries; fewer young people are drinking and the age of initiation is increasing. However, young people, their parents and others in their communities continue to believe that adolescent (excessive) drinking is the norm. This perception, and the concurrent misperception that the majority of parents are happy to provide their underage children with alcohol, creates a perceived culture of acceptance of youth alcohol consumption...
2017: PloS One
https://www.readbyqxmd.com/read/28106259/selection-on-parental-performance-opposes-selection-for-larger-body-mass-in-a-wild-population-of-blue-tits
#3
Caroline E Thomson, Florian Bayer, Nicholas Crouch, Samantha Farrell, Elizabeth Heap, Elizabeth Mittell, Mar Zurita-Cassinello, Jarrod D Hadfield
There is abundant evidence in many taxa for positive directional selection on body size, and yet little evidence for microevolutionary change. In many species, variation in body size is partly determined by the actions of parents, so a proposed explanation for stasis is the presence of a negative genetic correlation between direct and parental effects. Consequently, selecting genes for increased body size would result in a correlated decline in parental effects, reducing body size in the following generation...
January 20, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/28105710/experiences-of-parents-of-children-with-special-needs-at-school-entry-a-mixed-method-approach
#4
A Siddiqua, M Janus
BACKGROUND: The transition from pre-school to kindergarten can be complex for children who need special assistance due to mental or physical disabilities (children with 'special needs'). We used a convergent mixed method approach to explore parents' experiences with service provision as their children transitioned to school. METHODS: Parents (including one grandparent) of 37 children aged 4 to 6 years completed measures assessing their perceptions of and satisfaction with services...
January 20, 2017: Child: Care, Health and Development
https://www.readbyqxmd.com/read/28104626/deformational-plagiocephaly-in-normal-infants-a-systematic-review-of-causes-and-hypotheses
#5
Freia De Bock, Volker Braun, Herbert Renz-Polster
BACKGROUND: Deformational plagiocephaly (DP) is one of the most prevalent abnormal findings in infants and a frequent reason for parents to seek paediatric advice. OBJECTIVE: To systematically review the literature and identify evidence and hypotheses on the aetiology and determinants of DP in otherwise healthy infants. DESIGN: Systematic keyword search in all major biomedical databases to identify peer-reviewed publications reporting (a) empirical research or (b) hypotheses on the aetiology of DP in healthy, term infants...
January 19, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28104188/maternal-multiple-micronutrient-supplementation-and-other-biomedical-and-socioenvironmental-influences-on-children-s-cognition-at-age-9-12-years-in-indonesia-follow-up-of-the-summit-randomised-trial
#6
Elizabeth L Prado, Susy K Sebayang, Mandri Apriatni, Siti R Adawiyah, Nina Hidayati, Ayuniarti Islamiyah, Sudirman Siddiq, Benyamin Harefa, Jarrad Lum, Katherine J Alcock, Michael T Ullman, Husni Muadz, Anuraj H Shankar
BACKGROUND: Brain and cognitive development during the first 1000 days from conception are affected by multiple biomedical and socioenvironmental determinants including nutrition, health, nurturing, and stimulation. An improved understanding of the long-term influence of these factors is needed to prioritise public health investments to optimise human development. METHODS: We did a follow-up study of the Supplementation with Multiple Micronutrients Intervention Trial (SUMMIT), a double-blind, cluster-randomised trial of maternal supplementation with multiple micronutrients (MMN) or iron and folic acid (IFA) in Indonesia...
February 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28104117/a-report-on-the-positive-response-to-an-outdoor-nature-challenge-of-a-snow-camp-for-young-liver-transplant-patients
#7
E Soeda, K Hoshino, Y Izawa, C Takaoka, C Isobe, A Takahashi, N Takahashi, Y Yamada, N Shimojima, A Fujino, M Shinoda, Y Kitagawa, M Tanabe, S Nakamaru, N Taki, A Sekiguchi, Y Nakazawa, T Turukawa, T Kuroda
OBJECTIVES: More than two decades have passed since the first living donor liver transplantation was performed in Japan in 1989. There are many reports about problems in adherence to taking medication and medical follow-ups in children who received liver transplants, because there is no transition strategy for those children and parents or guardians. The objective of this study is to measure the effect of nature and outdoor activity to improve children's medical adherence. METHODS: We recruited participants from 9-year-old children who are attending the outpatient liver transplant clinic in a stable condition (no event such as rejection or surgical procedure within 6 months)...
January 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28104056/psychological-distress-in-jordanian-parents-of-children-with-autism-spectrum-disorder-the-role-of-positive-reappraisal-coping
#8
Ahmad Rayan, Muayyad Ahmad
BACKGROUND: Parents of children with autism spectrum disorder (ASD) frequently report poor psychological well-being. Positive reappraisal coping (PRC) is a coping strategy which offers a protective effect from anxiety and depression. However, the association between PRC and the psychological distress in parents of children with ASD has yet to be established. AIM: This study examines the association between PRC and the psychological distress in parents of children with ASD...
February 2017: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/28104029/-next-generation-sequencing-technology-for-susceptible-gene-screening-in-familial-non-medullary-thyroid-carcinoma
#9
L Dong, Y Yu, J P Yu, W J Hao, X Q Zheng, Y N Cheng, L Han, J Z Zhao, M Gao
Objective: To screen genes related to familial non-medullary thyroid carcinoma (FNMTC) using next-generation sequencing (NGS). Methods: A panel of NGS was designed and sequencing was performed for DNA samples extracted from peripheral blood leukocytes of FNMTC patients and sporadic non-medullary thyroid carcinoma (SNMTC) cases, respectively, and gene mutations were screened. In addition, the clinicopathological characteristics, including tumor size, extension of surgery, lymph node metastasis and extra-thyroidal extension, were compared between patients with or without mutations...
January 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28103809/dietary-treatment-of-crohn-s-disease-perceptions-of-families-with-children-treated-by-exclusive-enteral-nutrition-a-questionnaire-survey
#10
Vaios Svolos, Konstantinos Gerasimidis, Elaine Buchanan, Lee Curtis, Vikki Garrick, Jacqueline Hay, Susan Laird, Joanna Munro, Daniel R Gaya, Richard K Russell, Richard Hansen
BACKGROUND: Diet is strongly associated with the aetiology of Crohn's Disease (CD) and exclusive enteral nutrition (EEN) is the primary induction treatment in paediatric CD. This study explored opinions around the use of EEN and alternative novel, solid food-based diets (SFDs) expressed by paediatric patients with CD, previously treated with EEN and their parents. METHODS: This anonymous questionnaire surveyed families of CD patients treated with EEN over 1 year...
January 19, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28103266/adherence-to-prophylaxis-in-adolescents-and-young-adults-with-severe-haemophilia-a-quantitative-study-with-patients
#11
Sandra B van Os, Nick A Troop, Keith R Sullivan, Daniel P Hart
INTRODUCTION: haemophilia is an inherited bleeding disorder caused by a deficiency in one of the blood coagulation factors. For people affected by severe haemophilia, the deficiency can cause spontaneous internal bleeding. Most young people with severe haemophilia in the UK follow a preventative treatment regimen (prophylaxis) consisting of several intravenous injections of factor concentrate each week. There is good evidence that prophylaxis reduces bleeds whilst also improving quality of life...
2017: PloS One
https://www.readbyqxmd.com/read/28103183/association-between-parent-television-viewing-practices-and-setting-rules-to-limit-the-television-viewing-time-of-their-8-to-12-year-old-children-minnesota-2011-2015
#12
Martha Y Kubik, Olga V Gurvich, Jayne A Fulkerson
INTRODUCTION: Television (TV) viewing is popular among adults and children, and child TV-viewing time is positively associated with parent TV-viewing time. Efforts to limit the TV-viewing time of children typically target parent rule-setting. However, little is known about the association between parent TV-viewing practices and rule-setting. METHODS: We used baseline height and weight data and survey data collected from 2011 through 2015 on parents and their 8- to 12-year-old children (N = 212 parent/child dyads) who were participants in 2 community-based obesity prevention intervention trials conducted in metropolitan Minnesota...
January 19, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/28103181/positive-schemas-psychopathology-and-quality-of-life-in-children-with-pediatric-cancer-a-pilot-study
#13
Brae Anne McArthur, Douglas Strother, Fiona Schulte
PURPOSE: Research in the area of pediatric oncology has shown that although some children and youth diagnosed with this disease cope adaptively after their diagnosis, others continue to have long-term psychosocial difficulties. The potential mechanisms that may protect against the experience of psychopathology and poor quality of life within this population are not well known. The purpose of this pilot study was to utilize a new comprehensive measure of positive schemas to better understand the relationship between positive schemas, quality of life, and psychopathology, for children on active treatment for cancer...
January 19, 2017: Journal of Psychosocial Oncology
https://www.readbyqxmd.com/read/28102676/novel-antitumor-platinum-ii-conjugates-containing-the-nonsteroidal-anti-inflammatory-agent-diclofenac-synthesis-and-dual-mechanisms-of-antiproliferative-effects
#14
Francesco Paolo Intini, Juraj Zajac, Vojtech Novohradsky, Teresa Saltarella, Concetta Pacifico, Viktor Brabec, Giovanni Natile, Jana Kasparkova
One concept how to improve anticancer effects of conventional metallodrugs consists in conjugation of these compounds with other biologically (antitumor) active agents, acting by a different mechanism. Here, we present synthesis, biological effects, and mechanisms of action of new Pt(II) derivatives containing one or two nonsteroidal anti-inflammatory diclofenac (DCF) ligands also known for their antitumor effects. The antiproliferative properties of these metallic conjugates show that these compounds are potent and cancer cell selective cytotoxic agents exhibiting activity in cisplatin resistant and the COX-2 positive tumor cell lines...
January 19, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28101805/ketogenic-diet-in-pyruvate-dehydrogenase-complex-deficiency-short-and-long-term-outcomes
#15
Kalliopi Sofou, Maria Dahlin, Tove Hallböök, Marie Lindefeldt, Gerd Viggedal, Niklas Darin
OBJECTIVES: Our aime was to study the short- and long-term effects of ketogenic diet on the disease course and disease-related outcomes in patients with pyruvate dehydrogenase complex deficiency, the metabolic factors implicated in treatment outcomes, and potential safety and compliance issues. METHODS: Pediatric patients diagnosed with pyruvate dehydrogenase complex deficiency in Sweden and treated with ketogenic diet were evaluated. Study assessments at specific time points included developmental and neurocognitive testing, patient log books, and investigator and parental questionnaires...
January 18, 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/28101747/adolescents-conflict-management-styles-with-mothers-longitudinal-associations-with-parenting-and-reactance
#16
Lies Christine Missotten, Koen Luyckx, Susan Branje, Stijn Van Petegem
Adolescents' conflict management styles with parents are assumed to have an important impact on the quality of the parent-adolescent relationship and on adolescents' psychosocial development. Longitudinal research investigating possible determinants of these conflict management skills is scarce. The parenting context and adolescents' tendency to reject maternal authority are expected to shape adolescents' conflict management styles. Therefore, the present three-wave longitudinal study focuses on how parenting and adolescents' reactance relates to adolescents' conflict management styles and conflict frequency with mothers over time, and whether reactance may also explain the associations between parenting and certain conflict variables...
January 18, 2017: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/28100344/-recurrent-syncope-related-to-catecholaminergic-polymorphic-ventricular-tachycardia-due-to-de-novo-ryr2-r2401h-mutation
#17
X Liu, J X Li, J Z Hu, Y Shen, R Wan, Q M Xiong, Q Q Zhou, J Y Xie, J J Jin, X Yan, J H Yu, K Hong
Objective: To explore the clinical and molecular genetic features of a Chinese patient with catecholaminergic polymorphic ventricular tachycardia (CPVT). Methods: Clinical data including resting electrocardiography, echocardiography and treadmill exercise testing of a patient with CPVT admitted to our department in March 2013 were analyzed, and the peripheral venous blood samples of the patient and his family members and 400 ethnicity-matched healthy controls were obtained. All exons and exon-intron boundaries of the six CPVT-related genes including RYR2, CASQ2, TRDN, CALM1, KCNJ2 and ANKB were sequenced to detect the variants related to CPVT...
January 25, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28100305/environment-directed-activation-the-escherichia-coli-flhdc-operon-by-transposons
#18
Zhongge Zhang, Chika Kukita, Mir Zafri Humayun, Milton H Saier
The flagellar system in E. coli K12 is expressed under the control of the flhDC-encoded master regulator, FlhDC. Transposition of insertion sequence (IS) elements to the upstream flhDC promoter region up-regulates transcription of this operon, resulting in more rapid motility. Wang and Wood (2011) provided evidence that insertion of IS5 into upstream activating sites occurs at higher rates in semisolid agar media in which swarming behavior is allowed as compared with liquid or solid media where swarming cannot occur...
January 17, 2017: Microbiology
https://www.readbyqxmd.com/read/28100122/using-the-self-determination-theory-to-understand-chinese-adolescent-leisure-time-physical-activity
#19
Lijuan Wang
PURPOSES: This study applies the self-determination theory (SDT) to test the hypothesized relationships among perceived autonomy support from parents, physical education (PE) teachers, and peers, the fulfilment of psychological needs (i.e., autonomy, competence, and relatedness), autonomous motivation, and leisure-time physical activity of Chinese adolescents. METHOD: There are 255 grade six to eight student participants from four middle schools around Shanghai, China included in this study...
January 19, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28099777/positive-selection-on-sperm-ion-channels-in-a-brooding-brittle-star-consequence-of-life-history-traits-evolution
#20
A A-T Weber, L Abi-Rached, N Galtier, A Bernard, J I Montoya-Burgos, A Chenuil
Closely related species are key models to investigate mechanisms leading to reproductive isolation and early stages of diversification, also at the genomic level. The brittle star cryptic species complex Ophioderma longicauda encompasses the sympatric broadcast spawning species C3 and the internal brooding species C5. Here we used de novo transcriptome sequencing and assembly in two closely related species displaying contrasting reproductive modes to compare their genetic diversity and to investigate the role of natural selection in reproductive isolation...
January 18, 2017: Molecular Ecology
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