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https://www.readbyqxmd.com/read/28334734/multinucleated-polyploidy-drives-resistance-to-docetaxel-chemotherapy-in-prostate-cancer
#1
Karuna Mittal, Shashi Donthamsetty, Ramneet Kaur, Chunhua Yang, Meenakshi V Gupta, Michelle D Reid, Da Hoon Choi, Padmashree C G Rida, Ritu Aneja
BACKGROUND: Docetaxel is the only FDA-approved first-line treatment for castration-resistant prostate cancer (CRPC) patients. Docetaxel treatment inevitably leads to tumour recurrence after an initial therapeutic response with generation of multinucleated polyploid (MP) cells. Here we investigated role of MP cells in clinical relapse of CRPC. METHODS: Prostate cancer (PC-3) cells were treated with docetaxel (5 nM) for 3 days followed by a washout and samples were collected at close intervals over 35 days post drug washout...
March 23, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28334177/genetic-and-environmental-integration-of-the-hawkmoth-pollination-syndrome-in-ruellia-humilis-acanthaceae
#2
John S Heywood, Joseph S Michalski, Braden K McCann, Amber D Russo, Kara J Andres, Allison R Hall, Tessa C Middleton
Background and Aims: The serial homology of floral structures has made it difficult to assess the relative contributions of selection and constraint to floral integration. The interpretation of floral integration may also be clouded by the tacit, but largely untested, assumption that genetic and environmental perturbations affect trait correlations in similar ways. In this study, estimates of both the genetic and environmental correlations between components of the hawkmoth pollination syndrome are presented for chasmogamous flowers of Ruellia humilis , including two levels of control for serial homology...
February 28, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28333529/the-long-arm-of-childhood-preschool-associations-with-adolescent-health
#3
Terri J Sabol, Lindsay Till Hoyt
The current study examines the extent to which participation in preschool at age 4 is associated with blood pressure, body mass index, and awakening cortisol at age 15. We capitalize on data from the National Institute of Child Health and Human Development Study of Early Child Care and Youth Development to examine differences in adolescent health among children who attended preschool, parental care, or home-based care at age 4 (n = 742). Using quasi-experimental methods, we found that preschool participation was associated with multiple positive health outcomes in adolescence...
April 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28333519/-doctor-are-you-listening-communication-about-children-s-mental-health-and-psychosocial-concerns
#4
Anne E Pidano, Madhavi M Padukkavidana, Lisa Honigfeld
Effective communication is critical, including in the pediatric primary care setting. Pediatric primary care providers (PPCPs) are in a unique position to address psychosocial and mental health concerns during office visits, and effective communication skills play a crucial role in providing an opportunity for parents and patients to disclose and discuss such concerns. In this article, the authors encourage two relatively simple strategies that have shown potential for enhancing effective communication in pediatric primary care regarding mental health and psychosocial issues: (a) ensure that pediatric residents and practicing providers have access to brief, targeted communications training and (b) strongly promote the use of screening tools both to encourage discussion and to assist in identifying children who may benefit from further assessment and/or treatment...
March 2017: Families, Systems & Health: the Journal of Collaborative Family Healthcare
https://www.readbyqxmd.com/read/28333490/harsh-parenting-child-behavior-problems-and-the-dynamic-coupling-of-parents-and-children-s-positive-behaviors
#5
Erika Lunkenheimer, Nilam Ram, Elizabeth A Skowron, Peifeng Yin
We examined self-reported maternal and paternal harsh parenting (HP) and its effect on the moment-to-moment dynamic coupling of maternal autonomy support and children's positive, autonomous behavior. This positive behavior coupling was measured via hidden Markov models as the likelihood of transitions into specific positive dyadic states in real time. We also examined whether positive behavior coupling, in turn, predicted later HP and child behavior problems. Children (N = 96; age = 3.5 years at Time 1) and mothers completed structured clean-up and puzzle tasks in the laboratory...
March 23, 2017: Journal of Family Psychology: JFP
https://www.readbyqxmd.com/read/28333218/gay-fathers-motivations-for-and-feelings-about-surrogacy-as-a-path-to-parenthood
#6
L Blake, N Carone, E Raffanello, Jenna Slutsky, A A Ehrhardt, S Golombok
STUDY QUESTION: Why do gay men choose to start their families through surrogacy? SUMMARY ANSWER: Most fathers chose surrogacy because they considered adoption to be a less desirable and/or accessible path to parenthood. WHAT IS KNOWN ALREADY: Little is known of gay fathers' motivations to use surrogacy as a path to parenthood over and above other forms of family building, such as adoption, and no studies have examined fathers' satisfaction with the surrogacy process...
February 23, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28332245/parental-attributions-for-positive-behaviours-in-children-with-autism-spectrum-disorder
#7
P Bussanich, S L Hartley, D Bolt
BACKGROUND: The present study examined parental attributions for positive child behaviour in children with Autism Spectrum Disorder (ASD) and their association with parent outcomes. METHOD: In total, 175 couples who had a child with ASD (5-12 years) completed measures about the child's positive behaviour, ASD symptoms, functional skills and negative behaviour problems, and their own positive and negative affect and closeness in the parent-child relationship. A comparison group of 170 couples who had a child without a neurodevelopmental disability also completed measures...
March 22, 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/28332204/evaluation-of-hmw-gs-20-and-2-2-from-near-isogenic-lines-nils-of-wheat-variety-hd2329-for-bread-quality-improvement
#8
Sonia Goel, Sapna Grewal, N K Singh
BACKGROUND: Hexaploid wheat (Triticum aestivum L.) dominates the list of the most important human food sources ever. Its complex genetic background is the reason behind the wide diversity that exists in nutritional as well as food end- product quality. High molecular weight glutenin subunits (HMW-GS) are the main grain storage proteins in the endosperm of wheat and related species. It is well established that the composition and quantity of allelic variation in (HMW-GS) genes substantially affect the taste and appearance of dough products and therefore work in this area is highly desired...
March 23, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28332077/a-qualitative-study-to-explore-the-views-and-attitudes-towards-prenatal-testing-in-adults-who-have-muenke-syndrome-and-their-partners
#9
Julie Phipps, Heather Skirton
Muenke syndrome constitutes the most common syndromic form of craniosynostosis, occurring in 1 in 30,000 live births. The phenotype is variable, ranging from no clinical findings to complex presentation. Facilitating reproductive decision making for couples at genetic risk of having a child with Muenke syndrome is an important aspect of genetic counselling. Prenatal genetic testing for Muenke syndrome is accurate; however the value of testing is uncertain with a variable phenotype. The purpose of this study was to explore attitudes towards prenatal testing in couples where one partner had tested positive for the Muenke mutation...
March 22, 2017: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/28332065/practices-and-attitudes-of-missouri-school-nurses-regarding-immunization-records-and-select-immunizations-of-graduating-high-school-seniors
#10
Darson L Rhodes, Michele Draper, Kendra Woolman, Carol Cox
School nurses play a key role in maintaining a healthy student population, and one of their roles includes maintaining vaccination records. Further, they can play an important role in advocating for human papillomavirus (HPV) and meningococcal vaccination for students. All Missouri public high school nurses were sent an electronic survey addressing the knowledge, attitudes, and practices regarding immunization records and HPV and meningococcal vaccination of high school seniors. Approximately 75% of nurses reported their schools did not have or they did not know if the school had a written policy regarding the release of vaccination records...
March 22, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28331972/safe-sleeping-positions-practice-and-policy-for-babies-with-cleft-palate
#11
Karen Davies, Iain A Bruce, Patricia Bannister, Peter Callery
Guidance recommends 'back to sleep' positioning for infants from birth in order to reduce the risk of sudden infant death. Exceptions have been made for babies with severe respiratory difficulties where lateral positioning may be recommended, although uncertainty exists for other conditions affecting the upper airway structures, such as cleft palate. This paper presents research of (i) current advice on sleep positioning provided to parents of infants with cleft palate in the UK; and (ii) decision making by clinical nurse specialists when advising parents of infants with cleft palate...
March 22, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28330970/variation-in-family-experience-of-pediatric-inpatient-care-as-measured-by-child-hcahps
#12
Sara L Toomey, Marc N Elliott, Alan M Zaslavsky, David J Klein, Sifon Ndon, Shannon Hardy, Melody Wu, Mark A Schuster
BACKGROUND: Making national comparisons of family experience of inpatient pediatric care has been limited by the lack of a publicly available survey. The Agency for Healthcare Research and Quality and Centers for Medicare & Medicaid Services commissioned development of the Child Hospital Consumer Assessment of Healthcare Providers and Systems Survey to address this gap. Using Child Hospital Consumer Assessment of Healthcare Providers and Systems Survey, we measured performance of hospitals in a national field test...
March 22, 2017: Pediatrics
https://www.readbyqxmd.com/read/28330885/dientamoeba-fragilis-a-commensal-in-children-in-danish-day-care-centers
#13
Pikka Jokelainen, Betina Hebbelstrup Jensen, Bente Utoft Andreassen, Andreas Munk Petersen, Dennis Röser, Karen A Krogfelt, Henrik V Nielsen, Christen R Stensvold
Dientamoeba fragilis is an intestinal protozoan of debated clinical significance. Here, we present cross-sectional and longitudinal observations on D. fragilis in children aged 0-6 years from a 1-year multi-day-care-center cohort study set in Copenhagen, Denmark. The inclusion period for the cohort was 2009-2012. Stool samples collected from the children were accompanied by questionnaires completed by the parents or guardians of the children. Using real-time PCR, D. fragilis was detected in the first stool sample from 97 (68...
March 22, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28330071/unexpected-formation-of-n-phenyl-thiophosphorohydrazidic-acid-o-s-dimethyl-ester-from-acephate-chemical-biotechnical-and-computational-study
#14
Vijay Kumar, Sukhmanpreet Kaur, Simranjeet Singh, Niraj Upadhyay
By the nucleophilic attack of phenylhydrazine on acephate in aqueous medium, a stable product N'-phenyl-thiophosphorohydrazidic acid O,S-dimethyl ester (1) was obtained and characterized by elemental, spectral and thermal analysis. Thermodynamic parameters, Ea, ΔH°, ΔS° and ΔG°, have found to be 62.15, -67.95, -0.068 and -20.05 kJ mol(-1) according to the Coats-Redfern equation. Analysis of interaction of 1 with BSA protein was done by using the UV-Vis and FTIR spectroscopic methods. The observed binding constants was 1...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28329853/early-origins-of-later-life-psychological-well-being-a-novel-application-of-causal-mediation-analysis-to-life-course-research
#15
Tirth R Bhatta, Jeffrey M Albert, Eva Kahana, Nirmala Lekhak
Objectives: This study employs a novel approach to mediation analysis to clarify the influence of interrelated indicators of life course socioeconomic status (SES) on later life psychological well-being in India. Contrary to traditional approaches (i.e., use of product and difference-in-coefficients), we recognize the role of confounders in the estimation of total, direct, and indirect effects of parental education on respondents' psychological well-being. Method: Drawing from the first wave (2007-2010) of the Study on Global Ageing and Adult Health (SAGE) and adopting a counterfactual approach, we estimate both natural direct and indirect effects of parental education through individual educational attainment (secondarily, through household assets as an additional mediator) on respondents' life-satisfaction and quality of life (QOL)...
March 14, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28329807/are-you-sleeping-dyadic-associations-of-support-stress-and-worries-regarding-adult-children-on-sleep
#16
Amber J Seidel, Jeremy B Yorgason, Courtney A Polenick, Steven H Zarit, Karen L Fingerman
Purpose of the study: Sleep is a key factor in maintaining positive health and well-being throughout life. Although the negative outcomes of sleep problems are becoming better understood, less is known about how intergenerational relationships might affect sleep. Thus, this investigation examines the dyadic associations of support for, stress over, and worrying about adult children on sleep quality for husbands and wives. Design and Methods: The sample included 186 heterosexual married couples drawn from the Family Exchanges Study...
January 24, 2017: Gerontologist
https://www.readbyqxmd.com/read/28328127/partial-tetrasomy-11q-resulting-from-an-intrachromosomal-triplication-of-a-22-mb-region-of-chromosome-11
#17
Mariana Kekis, Carol Deeg, Sayaka Hashimoto, Aimee McKinney, Linda Erdman, Cecelia Green-Geer, Christine Shuss, Scott Hickey, Caroline Astbury, Robert E Pyatt
Intrachromosomal triplications are complex chromosomal rearrangements which arise during meiosis or mitosis and lead to a tetrasomic dose of the affected genomic regions. We describe a female patient harboring an intrachromosomal triplication who presented to the Genetics clinic with dysmorphic features, including telecanthus, flat facial profile, and prognathism, short stature, widely spaced nipples, multiple allergy complaints, loose bowel movements, and mild speech delay. Microarray analysis showed a copy number gain of a 22...
April 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28328120/a-qualitative-study-of-adolescents-understanding-of-biobanks-and-their-attitudes-toward-participation-re-contact-and-data-sharing
#18
Andrea M Murad, Melanie F Myers, Susan D Thompson, Rachel Fisher, Armand H Matheny Antommaria
While biobanks have become more prevalent, little is known about adolescents' views of key governance issues. We conducted semi-structured interviews with adolescents between 15 and 17 years old to solicit their views. All interviews were audiotaped and transcribed. Two investigators coded the transcripts and resolved any discrepancies through consensus. We conducted 18 interviews before reaching data saturation. Four participants (22%) had previously heard of a biobank. Many participants had misunderstandings about biobanks, some of which persisted after education...
April 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28326797/positive-and-negative-social-exchanges-experienced-by-fathers-and-mothers-of-children-with-autism
#19
Emily J Hickey, Lindsay Dubois, Sigan L Hartley
When faced with child-related challenges associated with autism spectrum disorder, positive and negative social exchanges may be critical to parents' psychological well-being. This study examined the types and sources of positive and negative social exchanges reported by mothers and fathers of children with autism spectrum disorder and their association with parental depressive symptoms in 176 families of children (5-12 years; 85% male) with autism spectrum disorder. One-way repeated measure multivariate analyses of variance and multilevel modeling were used...
March 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/28326564/parental-serum-alkaline-phosphatase-activity-as-an-auxiliary-tool-for-prenatal-diagnosis-of-hypophosphatasia
#20
Yuichiro Takahashi, Hideaki Sawai, Jun Murotsuki, Shuhei Satoh, Takahiro Yamada, Hiromi Hayakawa, Yutaka Kouduma, Masakatsu Sase, Atsushi Watanabe, Osamau Miyazaki, Gen Nishimura
OBJECTIVE: To clarify the usefulness of parental Alkaline phosphatase (ALP) for prenatal diagnosis of hypophosphatasia (HPP). METHODS: Maternal (m) and paternal (p) ALP values were measured in 77 cases from A multi-center cohort (fetal-skeletal dysplasia forum in Japan) of cases with short limbs on ultrasonography during pregnancy. After birth, X-rays, cord blood ALP, and gene analysis were evaluated to achieve an exact diagnosis. The screening usefulness of ALP was examined retrospectively...
March 22, 2017: Prenatal Diagnosis
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