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Brain tumors

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https://www.readbyqxmd.com/read/28110445/non-invasive-photodynamic-therapy-in-brain-cancer-by-use-of-tb-3-doped-laf3-nanoparticles-in-combination-with-photosensitizer-through-x-ray-irradiation-a-proof-of-concept-study
#1
Min-Hua Chen, Yi-Jhen Jenh, Sheng-Kai Wu, Yo-Shen Chen, Nobutaka Hanagata, Feng-Huei Lin
The use of photodynamic therapy (PDT) in the treatment of brain cancer has produced exciting results in clinical trials over the past decade. PDT is based on the concept that a photosensitizer exposed to a specific light wavelength produces the predominant cytotoxic agent, to destroy tumor cells. However, delivering an efficient light source to the brain tumor site is still a challenge. The light source should be delivered by placing external optical fibers into the brain at the time of surgical debulking of the tumor...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28110235/relationship-between-expression-of-vascular-endothelial-growth-factor-and-the-proliferation-of-prolactinomas
#2
Nan Li Ya, ZhiQuan Jiang
OBJECTIVE: Prolactinomas are the most common functional hormone-producing pituitary lesions, accounting for 30-40% of all pituitary tumors, while in autopsy series their incidence reaches 50%. However, patients with prolactinoma had a higher recurrence percentage and rate than patients with acromegaly or Cushing's disease. Furthermore, prolactinomas have the highest rate of recurrence post-surgery as compared with other pituitary adenomas. At present, this behavior of prolactinoma is largely unexplained, but may be related to definition of cure, or to more frequent microscopic tumor infiltration into normal pituitary tissue, which is not removed at surgery...
December 14, 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28109958/optical-barcoding-for-single-clone-tracking-to-study-tumor-heterogeneity
#3
Malte Mohme, Cecile L Maire, Kristoffer Riecken, Svenja Zapf, Tim Aranyossy, Manfred Westphal, Katrin Lamszus, Boris Fehse
Intratumoral heterogeneity has been identified as one of the strongest drivers of treatment resistance and tumor recurrence. Therefore, investigating the complex clonal architecture of tumors over time has become a major challenge in cancer research. We developed a new fluorescent "optical barcoding" technique that allows fast tracking, identification, and quantification of live cell clones in vitro and in vivo using flow cytometry (FC). We optically barcoded two cell lines derived from malignant glioma, an exemplary heterogeneous brain tumor...
January 18, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28109861/preoperative-rtms-language-mapping-in-speech-eloquent-brain-lesions-resected-under-general-anesthesia-a-pair-matched-cohort-study
#4
Philipp Hendrix, Sebastian Senger, Andreas Simgen, Christoph J Griessenauer, Joachim Oertel
OBJECTIVE: The value of preoperative rTMS language mapping for function preservation in surgery of speech eloquent lesions under general anesthesia remains to be determined. METHODS: The authors prospectively enrolled 20 consecutive right-handed patients with a malignant, left-sided perisylvian language eloquent brain tumor. All patients were subjected to surgical resection under general anesthesia guided by preoperative rTMS language mapping (rTMS group, 2014 - 2016)...
January 18, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28109792/bisacodyl-and-its-cytotoxic-activity-on-human-glioblastoma-stem-like-cells-implication-of-inositol-1-4-5-triphosphate-receptor-dependent-calcium-signaling
#5
Jihu Dong, Francisco Aulestia, Suzana Assad Kahn, Maria Zeniou, Luiz Gustavo Dubois, Elias A El-Habr, François Daubeuf, Nassera Tounsi, Samuel H Cheshier, Nelly Frossard, Marie-Pierre Junier, Hervé Chneiweiss, Isabelle Néant, Marc Moreau, Catherine Leclerc, Jacques Haiech, Marie-Claude Kilhoffer
Glioblastoma is the most common malignant brain tumor. The heterogeneity at the cellular level, metabolic specificities and plasticity of the cancer cells are a challenge for glioblastoma treatment. Identification of cancer cells endowed with stem properties and able to propagate the tumor in animal xenografts has opened a new paradigm in cancer therapy. Thus, to increase efficacy and avoid tumor recurrence, therapies need to target not only the differentiated cells of the tumor mass, but also the cancer stem-like cells...
January 18, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28109103/-value-of-diffusion-weighted-imaging-1-h-magnetic-resonance-spectroscopy-and-3d-whole-brain-arterial-spin-labeling-in-the-diagnosis-of-medulloblastoma
#6
Dong-Liang Cheng, Wen-Sheng Wang, Yi-Xin Hu, Meng-Lin Chen, Ge Wen, Li-Na Cheng, Jing Wu, Liu-Qing Yan
OBJECTIVE: To explore the value of diffusion-weighted imaging (DWI), (1)H-magnetic resonance spectroscopy (1H-MRS) and 3D whole-brain arterial spin labeling (3D ASL) in the diagnosis of medulloblastoma in the posterior cranial fossa. METHODS: The magnetic resonance imaging (MRI) findings of 16 patients with pathologically confirmed medulloblastoma in the posterior cranial fossa were analyzed retrospectively. All the patients were examined with plane and enhanced brain MRI scans; 5 patients also underwent examinations with DWI, 12 with MRS, and 5 with 3D ASL...
January 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28108988/blood-brain-barrier-closure-time-after-controlled-ultrasound-induced-opening-is-independent-of-opening-volume
#7
Meaghan A O'Reilly, Olivia Hough, Kullervo Hynynen
OBJECTIVES: Microbubble-mediated focused ultrasound (US) opening of the blood-brain barrier (BBB) has shown promising results for the treatment of brain tumors and conditions such as Alzheimer disease. Practical clinical implementation of focused US treatments would aim to treat a substantial portion of the brain; thus, the safety of opening large volumes must be investigated. This study investigated whether the opened volume affects the time for the BBB to be restored after treatment...
January 21, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28108861/in-vivo-magnetic-resonance-imaging-investigating-the-development-of-experimental-brain-metastases-due-to-triple-negative-breast-cancer
#8
Amanda M Hamilton, Paula J Foster
Triple negative breast cancer (TNBC), when associated with poor outcome, is aggressive in nature with a high incidence of brain metastasis and the shortest median overall patient survival after brain metastasis development compared to all other breast cancer subtypes. As therapies that control primary cancer and extracranial metastatic sites improve, the incidence of brain metastases is increasing and the management of patients with breast cancer brain metastases continues to be a significant clinical challenge...
January 21, 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/28108853/brain-metastasis-of-carcinoma-ex-pleomorphic-adenoma-of-the-parotid-gland-case-report-and-review-of-the-literature
#9
Ruth Lau, Alejandro Fernández-Coello, Noemí Vidal-Sarró, Dennis Céspedes, Angels Camins, Miren Taberna, Andreu Gabarrós
We present an extremely infrequent case of brain metastasis of a parotid tumor. To our knowledge, this is the second case reported of a brain metastasis of a malignant parotid tumor, carcinoma ex pleomorphic adenoma. Pleomorphic adenoma represents 60% of tumors of the parotid gland, and although it is a benign tumor, it can transform into carcinoma ex pleomorphic adenoma in 5% of cases, one of the most aggressive neoplasms of the salivary glands. We want to note the need for an accurate diagnostic. Thanks to aggressive surgical management, our patient survived more than 1½ years...
January 20, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28108836/smad-dependent-signaling-plays-a-detrimental-role-in-a-fly-model-of-smarcb1-deficiency-and-the-biology-of-atypical-teratoid-rhabdoid-tumors
#10
Astrid Jeibmann, Jacqueline Schulz, Kristin Eikmeier, Pascal D Johann, Katharina Thiel, Isabel Tegeder, Oliver Ambrée, Michael C Frühwald, Stefan M Pfister, Marcel Kool, Werner Paulus, Martin Hasselblatt
Atypical teratoid/rhabdoid tumors (ATRT) are highly malignant brain tumors arising in young children. The majority of ATRT is characterized by inactivation of the chromatin remodeling complex member SMARCB1 (INI1/hSNF5). Little is known, however, on downstream pathways involved in the detrimental effects of SMARCB1 deficiency which might also represent targets for treatment. Using Drosophila melanogaster and the Gal4-UAS system, modifier screens were performed in order to identify the role of SMAD dependent signaling in the lethal phenotype associated with knockdown of snr1, the fly homolog of SMARCB1...
January 20, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28108639/prevalence-of-epilepsy-seizures-as-a-comorbidity-of-neurologic-disorders-in-nursing-homes
#11
Angela K Birnbaum, Ilo E Leppik, Kenneth Svensden, Lynn E Eberly
OBJECTIVE: To determine the prevalence of epilepsy/seizure (epi/sz) comorbid with other neurologic disorders in elderly nursing home residents and to examine demographic and regional variability and associations with clinical characteristics. METHODS: We studied 5 cross-sectional cohorts of all residents in any Medicare/Medicaid-certified nursing home in the United States on July 15 of each year from 2003 to 2007. Epi/sz was identified by ICD-9 codes (345.xx or 780...
January 20, 2017: Neurology
https://www.readbyqxmd.com/read/28108511/biomarker-based-pet-imaging-of-diffuse-intrinsic-pontine-glioma-in-mouse-models
#12
Susanne Kossatz, Brandon Carney, Melanie E Schweitzer, Giuseppe Carlucci, Vesselin Miloushev, Uday B Maachani, Prajwal Rajappa, Kayvan Keshari, David J Pisapia, Wolfgang A Weber, Mark M Souweidane, Thomas Reiner
Diffuse intrinsic pontine glioma (DIPG) is a childhood brainstem tumor with a universally poor prognosis. Here, we characterize on a positron emission tomography (PET) probe for imaging DIPG in vivo. In human histological tissues, the probes target, poly(ADP)ribose polymerase 1 (PARP1), was highly expressed in DIPG compared to normal brain. PET imaging allowed for the sensitive detection of DIPG in a genetically engineered mouse model (GEMM), and probe uptake correlated to histologically determined tumor infiltration...
January 20, 2017: Cancer Research
https://www.readbyqxmd.com/read/28108463/targeting-glioblastoma-with-car-t-cells
#13
(no author information available yet)
CAR T cells targeting IL13Rα2 proved effective against recurrent multifocal leptomeningeal glioblastoma, according to a case report. Direct delivery of the therapy into the cerebrospinal fluid was well tolerated, completely eliminating the patient's brain and spinal tumors for 7.5 months, during which the patient resumed his normal activities.
January 20, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28108422/role-of-microglia-autophagy-in-microglia-activation-after-traumatic-brain-injury
#14
Yichao Jin, Ran Wang, Shaofeng Yang, Xiaohua Zhang, Jiong Dai
OBJECTIVE: Role of microglia autophagy in microglia activation after traumatic brain injury (TBI) remains elusive. Here, we evaluated role of microglia autophagy in microglia activation after traumatic brain injury (TBI) in rats. METHODS: TBI was induced by a fluid percussion TBI device. All rats were killed at 24 h after TBI. The ipsilateral hippocampus in all rats was analyzed with hematoxylin and eosin staining; Immunohistochemistry and western blotting of IBA-1 was used to determine the changes of microglia activation; Double staining of microtubule-associated protein light chain 3 (LC-3), Beclin-1 and IBA-1 was used to assess the changes of microglia autophagy; enzyme-linked immunosorbent assay (ELISA) of tumor necrosis factor receptor-alpha (TNF-α) and interleukin-1β (IL-1β) was used to evaluate the changes of inflammatory responses; terminal deoxynucleoitidyl transferase mediated nick end labeling staining (TUNEL) was used to determine cell death in ipsilateral hippocampus...
January 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28106693/a-tentorial-cavernous-angioma-with-hemorrhage-mimicking-a-hypervascular-brain-tumor
#15
Xiaodong Shi, Qiyong Jiang, Xiaogang Liu, Xunhui Yuan, Gaoling Sun, Jianyi Niu, Liemei Guo
No abstract text is available yet for this article.
January 18, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28106495/comparison-of-prognostic-indices-in-patients-who-undergo-melanoma-brain-metastasis-radiosurgery
#16
Hideyuki Kano, Alejandro Morales-Restrepo, Aditya Iyer, Gregory M Weiner, Seyed H Mousavi, John M Kirkwood, Ahmad A Tarhini, John C Flickinger, L Dade Lunsford
OBJECTIVE The goal of this study was to use 4 prognostic indices to compare survival times of patients who underwent Gamma Knife stereotactic radiosurgery (SRS) to treat melanoma brain metastases. METHODS The authors analyzed 422 consecutive patients (1440 brain metastases) who underwent Gamma Knife SRS. The median total brain tumor volume was 4.7 cm(3) (range 0.3-69.3 cm(3)), and the median number of metastases was 2 (range 1-32). One hundred thirty-two patients underwent whole-brain radiation therapy. Survival times were compared using recursive partitioning analysis (RPA), the Score Index for Radiosurgery (SIR), the Basic Score for Brain Metastases (BSBM), and the Diagnosis-Specific Graded Prognostic Assessment (DS-GPA)...
January 20, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28106227/can-ngal-be-employed-as-prognostic-and-diagnostic-biomarker-in-human-cancers-a-systematic-review-of-current-evidence
#17
Laura Roli, Valentina Pecoraro, Tommaso Trenti
BACKGROUND: Some studies have reported differentially altered neutrophil gelatinase-associated lipocalin (NGAL) levels in several malignancies. We evaluated NGAL measured in plasma or urine as both prognostic and diagnostic marker for different types of human tumors. METHODS: We performed systematic electronic searches in Medline, Embase and CRDTAS. Studies were included if they evaluated NGAL as a prognostic or diagnostic marker for human cancers. The selection of the studies, screening of the full texts and data extraction were conducted independently by 2 authors...
January 16, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28106146/asymmetric-waveforms-decrease-lethal-thresholds-in-high-frequency-irreversible-electroporation-therapies
#18
Michael B Sano, Richard E Fan, Lei Xing
Irreversible electroporation (IRE) is a promising non-thermal treatment for inoperable tumors which uses short (50-100 μs) high voltage monopolar pulses to disrupt the membranes of cells within a well-defined volume. Challenges with IRE include complex treatment planning and the induction of intense muscle contractions. High frequency IRE (H-FIRE) uses bursts of ultrashort (0.25-5 μs) alternating polarity pulses to produce more predictable ablations and alleviate muscle contractions associated with IRE...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28105799/molecular-characterization-and-functional-analysis-of-a-piscidin-gene-in-large-yellow-croaker-larimichthys-crocea
#19
Jing Yang, Xin-Jiang Lu, Fang-Chao Chai, Jiong Chen
The piscidin family, which includes potent antimicrobial peptides with broad-spectrum activity, plays an important role in the innate immune system of fish. In this study, we cloned piscidin-5-like type 3 (Lcpis5lt3) in large yellow croaker (Larimichthys crocea). Multiple alignments with other known piscidins revealed amino acid conservation throughout the fish, especially at the signal peptide (22 amino acids). The phylogenetic tree confirmed that Lcpis5lt3 and large yellow croaker piscidin-5-like proteins were grouped together to form a branch...
November 18, 2016: Zool Res
https://www.readbyqxmd.com/read/28105536/a-long-noncoding-rna-uca1-promotes-proliferation-and-predicts-poor-prognosis-in-glioma
#20
W Zhao, C Sun, Z Cui
BACKGROUND: Acting as a proto-oncogene, long noncoding RNAs (lncRNAs) urothelial carcinoembryonic antigen 1 (UCA1) plays a key role in the occurrence and development of several human tumors. However, the expression and biological functions of UCA1 in glioma are less known. This study discussed the expression of UCA1 in glioma and its effect on the proliferation and cell cycle of glioma cells. METHOD: LncRNA UCA1 expressions in 64 glioma samples (Grade I-II in 22 cases and Grade III-IV in 42 cases, according to WHO criteria) and 10 normal brain samples were detected using real-time fluorescence quantitative PCR...
January 19, 2017: Clinical & Translational Oncology
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