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https://www.readbyqxmd.com/read/29448256/serum-levels-of-fgf21-and-prediction-of-cardiovascular-events
#1
Yongde Luo, Weiqin Lu
No abstract text is available yet for this article.
February 15, 2018: Cardiology
https://www.readbyqxmd.com/read/29448103/fgf-21-deficiency-slows-gastric-emptying-and-reduces-initial-blood-alcohol-concentration-in-mice-exposed-to-acute-alcohol-in-fasting-state
#2
Guicheng Wu, Yanlong Liu, Yunhuan Liu, Lihua Zhang, Haiyang Zhao, Liming Liu, Cuiqing Zhao, Wenke Feng
Excess alcohol consumption can lead to alcoholic liver disease. Fibroblast growth factor 21 (FGF21) is a metabolic regulator with multiple physiologic functions. Previous study demonstrated that FGF21 deficiency exacerbated alcohol-induced liver injury and exogenous FGF21 administration protected liver from chronic alcohol-induced injury. In this study, we aimed to explore the role of FGF21 in alcohol metabolism in mice. FGF21 knockout (KO) mice and the wild time (WT) control mice were divided into two groups and fasted for 24 h followed by a bonus of alcohol treatment at a dose of 5 g/kg body weight via gavage...
February 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29445083/fibroblast-growth-factor-21-prevents-diabetic-cardiomyopathy-via-ampk-mediated-antioxidation-and-lipid-lowering-effects-in-the-heart
#3
Hong Yang, Anyun Feng, Sundong Lin, Lechu Yu, Xiufei Lin, Xiaoqing Yan, Xuemian Lu, Chi Zhang
Our previous studies showed that both exogenous and endogenous FGF21 inhibited cardiac apoptosis at the early stage of type 1 diabetes. Whether FGF21 induces preventive effect on type 2 diabetes-induced cardiomyopathy was investigated in the present study. High-fat-diet/streptozotocin-induced type 2 diabetes was established in both wild-type (WT) and FGF21-knockout (FGF21-KO) mice followed by treating with FGF21 for 4 months. Diabetic cardiomyopathy (DCM) was diagnosed by significant cardiac dysfunction, remodeling, and cardiac lipid accumulation associated with increased apoptosis, inflammation, and oxidative stress, which was aggravated in FGF21-KO mice...
February 14, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29444136/ly2405319-an-analog-of-fibroblast-growth-factor-21-ameliorates-%C3%AE-smooth-muscle-actin-production-through-inhibition-of-the-succinate-g-protein-couple-receptor-91-gpr91-pathway-in-mice
#4
Cong Thuc Le, Giang Nguyen, So Young Park, Dae Hee Choi, Eun-Hee Cho
Fibroblast growth factor 21 (FGF21) is an important metabolic regulator expressed predominantly in the liver. In this study, we evaluated the role of LY2405319, an analogue of FGF21, in hepatic stellate cell (HSC) activation and in a methionine and choline-deficient (MCD)-diet induced mouse model of liver fibrosis. During liver injury, HSCs trans-differentiate into activated myofibroblasts which produce alpha-smooth muscle actin (α-SMA) and become a major cell type in hepatic fibrogenesis. Succinate and succinate receptor (GPR91) signaling has emerged as a regulator to promote α-SMA production in MCD diet- induced mice...
2018: PloS One
https://www.readbyqxmd.com/read/29436198/serum-fibroblast-growth-factor-21-and-new-onset-metabolic-syndrome-koges-arirang-study
#5
Jung Ran Choi, Jang Young Kim, Il Hwan Park, Ji Hye Huh, Ki Woo Kim, Seung Kuy Cha, Kyu Sang Park, Joon Hyung Sohn, Jong Taek Park, Sang Baek Koh
PURPOSE: Fibroblast growth factor 21 (FGF21) is a crucial metabolic regulator, with multiple favorable effects on glucose homeostasis and lipid metabolism. Since serum FGF21 level has been implicated as a potential marker for the early identification of metabolic syndrome (MetS), we investigated the association between serum FGF21 level and the development of MetS in a population-based prospective study. MATERIALS AND METHODS: We conducted a prospective study of 221 randomly sampled adults without MetS from a general population-based cohort study who were examined from 2005-2008 (baseline) and from 2008-2011 (follow-up)...
March 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29434695/tcf4-%C3%AE-catenin-complex-is-directly-upstream-of-fgf21-in-mouse-stomach-cancer-cells
#6
Jihua Pei, Na Song, Limin Wu, Jinbo Qi, Shenglong Xia, Changlong Xu, Bo Zheng, Jun Yang, Yanyan Qiu, Haijun Wang, Yi Jiang
Fibroblast growth factor 21 (FGF21) as a member of the FGFs serves a key role in glucose homeostasis and protection of the liver, heart, kidney and skin from damage as well as cancer cell development. In addition, transcription of FGF21 is sensitive to diverse damages; however, the role of the transcriptional regulator of FGF21 in cancer cells remains to be elucidated. FGFs were identified to have dominant expression in cancer cells; therefore, mouse forestomach carcinoma (MFC) cells were used in the present study, which is a mouse stomach cancer cell strain for identifying the FGF21 regulators...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29434210/epigenetic-modulation-of-fgf21-in-the-perinatal-mouse-liver-ameliorates-diet-induced-obesity-in-adulthood
#7
Xunmei Yuan, Kazutaka Tsujimoto, Koshi Hashimoto, Kenichi Kawahori, Nozomi Hanzawa, Miho Hamaguchi, Takami Seki, Makiko Nawa, Tatsuya Ehara, Yohei Kitamura, Izuho Hatada, Morichika Konishi, Nobuyuki Itoh, Yoshimi Nakagawa, Hitoshi Shimano, Takako Takai-Igarashi, Yasutomi Kamei, Yoshihiro Ogawa
The nutritional environment to which animals are exposed in early life can lead to epigenetic changes in the genome that influence the risk of obesity in later life. Here, we demonstrate that the fibroblast growth factor-21 gene (Fgf21) is subject to peroxisome proliferator-activated receptor (PPAR) α-dependent DNA demethylation in the liver during the postnatal period. Reductions in Fgf21 methylation can be enhanced via pharmacologic activation of PPARα during the suckling period. We also reveal that the DNA methylation status of Fgf21, once established in early life, is relatively stable and persists into adulthood...
February 12, 2018: Nature Communications
https://www.readbyqxmd.com/read/29427162/fgf-21-elevated-il-10-production-to-correct-lps-induced-inflammation
#8
Jun-Yan Li, Nan Wang, Mir Hassan Khoso, Cheng-Bin Shen, Meng-Ze Guo, Xin-Xin Pang, De-Shan Li, Wen-Fei Wang
Fibroblast growth factor 21 (FGF-21) has been previously judged as a major metabolic regulator. In this paper, we show that FGF-21 has a potential role in anti-inflammation and immunoregulation. In vivo, treatment with exogenous FGF-21 can alleviate LPS-induced inflammation. In vitro, FGF-21 inhibited LPS-induced IL-1β expression in THP-1 cells. Furthermore, besides the NF-κB pathway, the mechanism of action of FGF-21 was observed to involve the elevation of IL-10 in the ERK1/2 pathway. This study clearly indicates that FGF21 can be used as an attractive target for the management of inflammatory disorders...
February 9, 2018: Inflammation
https://www.readbyqxmd.com/read/29424246/increased-plasma-fgf21-level-as-an-early-biomarker-for-insulin-resistance-and-metabolic-disturbance-in-obese-insulin-resistant-rats
#9
Pongpan Tanajak, Wanpitak Pongkan, Siriporn C Chattipakorn, Nipon Chattipakorn
Propose: To investigate the temporal relationship between plasma fibroblast growth factor 21 levels, insulin resistance, metabolic dysfunction and cardiac fibroblast growth factor 21 resistance in long-term high-fat diet-induced obese rats. METHODS: In total, 36 male Wistar rats were fed with either a normal diet or high-fat diet for 12 weeks. Blood was collected from the tail tip, and plasma was used to determine metabolic profiles and fibroblast growth factor 21 levels. Rats were sacrificed at weeks 4, 8 and 12, and the hearts were rapidly removed for the determination of cardiac fibroblast growth factor 21 signalling pathways...
February 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29421579/polyphenol-enriched-extract-of-rosa-rugosa-thunb-regulates-lipid-metabolism-in-diabetic-rats-by-activation-of-ampk-pathway
#10
Liu Liu, Mireguli Yasen, Dan Tang, Jianping Ye, Haji Akber Aisa, Xuelei Xin
This study was designed to investigate the mechanism of polyphenol-enriched extract of Rosa rugosa Thunb (RPE) in the control of dyslipidemia in diabetic rats. RPE was tested at three dosages (37.5 mg/kg, 75 mg/kg and 150 mg/kg) in the rat dyslipidemia model established with high fat diet feeding in combination with STZ injection (30 mg/kg). The RPE effect was evaluated after 4 weeks of treatment. In the RPE-treated rats, hepatic total cholesterol (TC) and triglyceride (TG) were significantly reduced, lipoprotein lipase (LPL) and liver lipase (HL) were significantly increased...
February 5, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29417398/effects-of-central-fgf21-infusion-on-the-hypothalamus-pituitary-thyroid-axis-and-energy-metabolism-in-rats
#11
Umit Yilmaz, Suat Tekin, Mehmet Demir, Yilmaz Cigremis, Suleyman Sandal
The aim of this study was to evaluate the impact of intracerebroventricular chronic fibroblast growth factor 21 (FGF21) infusion on hypothalamic-pituitary-thyroid (HPT) axis, energy metabolism, food intake and body weight. Thirty male Wistar albino rats were used and divided into three groups including control, sham (vehicle) and FGF21 infused groups (n = 10). Intracerebroventricularly, FGF21 and vehicle groups were infused for 7 days with FGF21 (0.72 µg/day) and artificial cerebrospinal fluid, respectively...
February 7, 2018: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/29410351/fibroblast-growth-factor-21-in-cardio-metabolic-disorders-a-systematic-review-and-meta-analysis
#12
Ishan Lakhani, Mengqi Gong, Wing Tak Wong, George Bazoukis, Konstantinos Lampropoulos, Sunny Hei Wong, William K K Wu, Martin C S Wong, Kwok-Leung Ong, Tong Liu, Gary Tse
BACKGROUND: Fibroblast growth factor 21 is a signalling protein involved in cell differentiation, morphogenesis, proliferation and metabolism. Recent studies have associated increased levels of FGF21 in the development of cardiovascular diseases, whereas others have reported no significant associations. Therefore, this systematic review and meta-analysis evaluated the its value in predicting the risk of cardio-metabolic disorders and mortality. METHODS: PubMed and EMBASE were searched until 5th September 2017 for studies that evaluated the roles of FGF21 levels in cardio-metabolic disorders...
February 1, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29401620/fgf21-is-induced-in-cisplatin-nephrotoxicity-to-protect-against-kidney-tubular-cell-injury
#13
Fanghua Li, Zhiwen Liu, Chengyuan Tang, Juan Cai, Zheng Dong
Cisplatin, a widely used cancer therapy drug, induces nephrotoxicity or acute kidney injury (AKI), but the underlying mechanism remains unclear, and renal protective approaches are not available. Fibroblast growth factor (FGF)21 is an endocrine factor that regulates glucose uptake, metabolism, and energy expenditure. However, recent work has also implicated FGF21 in cellular stress response under pathogenic conditions. The role and regulation of FGF21 in AKI are unclear. Here, we show that FGF21 was dramatically induced during cisplatin treatment of renal tubular cells in vitro and mouse kidneys in vivo...
January 22, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29378767/perilipin-5-deletion-unmasks-an-endoplasmic-reticulum-stress-fibroblast-growth-factor-21-axis-in-skeletal-muscle
#14
Magdalene K Montgomery, Ruzaidi Mokhtar, Jacqueline Bayliss, Helena C Parkington, Victor M Suturin, Clinton R Bruce, Matthew J Watt
Lipid droplets are critical for the regulation of lipid metabolism, and dysregulated lipid metabolism contributes to the pathogenesis of several diseases including type 2 diabetes. We generated mice with muscle-specific deletion of the lipid droplet-associated protein, perilipin 5 (PLIN5, Plin5MKO ), and investigated PLIN5's role in regulating skeletal muscle lipid metabolism, intracellular signalling and whole-body metabolic homeostasis. High-fat feeding induced changes in muscle lipid metabolism of Plin5MKO mice, which included increased fatty acid oxidation and oxidative stress, but surprisingly, a reduction in inflammation and endoplasmic reticulum (ER) stress...
January 29, 2018: Diabetes
https://www.readbyqxmd.com/read/29378327/trib3-limits-fgf21-induction-during-in-vitro-and-in-vivo-nutrient-deficiencies-by-inhibiting-c-ebp-atf-response-elements-in-the-fgf21-promoter
#15
Tiit Örd, Daima Örd, Tõnis Örd
Mammals must be able to endure periods of limited food availability, and the liver plays a central role in the adaptation to nutritional stresses. TRIB3 (Tribbles homolog 3) is a cellular stress-inducible gene with a liver-centric expression pattern and it has been implicated in stress response regulation and metabolic control. In the current article, we study the involvement of TRIB3 in responses to nutrient deficiencies, including fasting for up to 48 h in mice. We show that hepatic expression of Trib3 is increased after 48 h of fasting and mice with a targeted deletion of the Trib3 gene present elevated hepatic triglyceride content and liver weight at 48 h, along with an upregulation of lipid utilization genes in the liver...
January 26, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29375676/fibroblast-growth-factor-21-inhibition-aggravates-cardiac-dysfunction-in-diabetic-cardiomyopathy-by-improving-lipid-accumulation
#16
Cui Chen, Zheying Meng, Yuanyi Zheng, Bing Hu, E Shen
Diabetic cardiomyopathy (DCM) is one of the major causes of morbidity and mortality in diabetic patients. Recent studies have demonstrated an increased level of fibroblast growth factor 21 (FGF21) in the plasma of DCM patients, and FGF21 has been proven to be a cardiovascular protector of the heart. The present study aimed to further investigate the pathogenic role of FGF21 in DCM, hypothesizing that a lack of FGF21 may promote the progression of DCM by regulating the lipid metabolism, cardiac hypertrophy and cardiac fibrosis, thus deteriorating the cardiac dysfunction...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29371695/metformin-ameliorates-experimental-obesity-associated-autoimmune-arthritis-by-inducing-fgf21-expression-and-brown-adipocyte-differentiation
#17
Eun-Kyung Kim, Seung Hoon Lee, Seon-Young Lee, Jae-Kyung Kim, Joo Yeon Jhun, Hyun Sik Na, Se-Young Kim, Jong Young Choi, Chul Woo Yang, Sung-Hwan Park, Mi-La Cho
Rheumatoid arthritis (RA) is a systemic autoimmune disease involving excessive inflammation. Recently, RA associated with a metabolic disorder was revealed to be non-responsive to RA medications. Metformin has been reported to have a therapeutic effect on RA and obesity. The aim of this investigation was to study the therapeutic effect and the underlying mechanism of metformin's action in an experimental model of collagen-induced arthritis (CIA) associated with obesity. Metformin was administered daily for 13 weeks to mice with CIA that had been fed a high-fat diet...
January 26, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29367194/construction-of-fgf21-knockout-mouse-models-by-the-crispr-cas9-system
#18
Xu Liu, Ping Zhang, Xiao-Feng Zhang, Xing Li, Yu Bai, Ke-Rong Jia, Xiao-Dong Guo, Hao Zhang, Xiao-Yan Ma, Ming Cang, Dong-Jun Liu, Xu-Dong Guo
Fibroblast growth factors (FGFs) are multifunctional signal molecules between cells, regulating the various physiological functions of the organism. FGF21 is a regulatory factor of the FGF family and has been postulated to play important roles in hair follicle development and hair follicle growth cycle. To evaluate the roles of FGF21, we had established a FGF21 knockout mouse model, using the CRISPR/Cas9 technology. We had constructed a FGF21 targeting vector and microinjected it with Cas9 mRNA and gRNA into fertilized ova of FVB mice...
January 20, 2018: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/29359470/shining-light-on-the-metabolic-role-of-the-cytokine-tnfsf14-and-the-implications-on-hepatic-il-6-production
#19
Bernadette M Saunders, Caroline Rudnicka, Aleksandra Filipovska, Stefan Davies, Natalie Ward, Jana Hricova, Markus P Schlaich, Vance B Matthews
The cytokine Tumor Necrosis Factor Superfamily member 14, TNFSF14 (or LIGHT), is a controversial player in numerous diseases. We investigated the role of endogenously expressed TNFSF14 in diet-induced obesity in vivo. Firstly, we studied the effects of Tnfsf14 ablation on the development of obesity, glucose intolerance, insulin resistance, steatosis, tissue inflammation, and mitochondrial respiration in the liver. Secondly, we examined the role of TNFSF14 expression in hematopoietic cells on obesity and insulin sensitivity...
January 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29357809/coagonist-of-glp-1-and-glucagon-receptor-ameliorates-development-of-non-alcoholic-fatty-liver-disease
#20
Vishal Patel, Amit Joharapurkar, Samadhan Kshirsagar, Brijesh Sutariya, Maulik Patel, Hiren Patel, Dheerendra Pandey, Dipam Patel, Ramchandra Ranvir, Shekhar Kadam, Rajesh Bahekar, Mukul Jain
Background-Obesity, diabetes and dyslipidemic are the key pathogenic stimulus that enhances progression of non-alcoholic fatty liver disease (NAFLD). Coagonist of glucagon like-peptide-1 (GLP-1) receptor (GLP-1R) and glucagon receptor (GCGR) are being evaluated for obesity and diabetes. GLP-1 analogues have shown to reverse diabetes and obesity. Glucagon treatment reduces lipids after acute and chronic treatment. Objective-In this study, we have investigated the effect of coagonist on prevention of NAFLD induced by long-term feeding of high fat diet (HFD)...
January 18, 2018: Cardiovascular & Hematological Agents in Medicinal Chemistry
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