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https://www.readbyqxmd.com/read/28623131/fgf21-regulates-melanogenesis-in-alpaca-melanocytes-via-erk1-2-mediated-mitf-downregulation
#1
Ruiwei Wang, Tianzhi Chen, Bingling Zhao, Ruiwen Fan, Kaiyuan Ji, Xiuju Yu, Xianjun Wang, Changsheng Dong
Fibroblast growth factor 21 (FGF21) is known as a metabolic regulator to regulate the metabolism of glucose and lipids. However, the underlying mechanism of FGF21 on melanin synthesis remains unknown. Therefore, the current study investigates the effect of FGF21 on melanogenesis in alpaca melanocytes. We transfected the FGF21 into alpaca melanocytes, then detected the melanin contents, protein and mRNA levels of pigmentation-related genes in order to determine the melanogenesis-regulating pathway of FGF21. The results showed that FGF21 overexpression suppressed melanogenesis and decreased the expression of the major target genes termed microphthalmia-associated transcription factor (MITF) and its downstream genes, including tyrosinase (TYR) and tyrosinase-related protein 2 (TRP2)...
June 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28607005/opa1-deficiency-promotes-secretion-of-fgf21-from-muscle-that-prevents-obesity-and-insulin-resistance
#2
Renata Oliveira Pereira, Satya M Tadinada, Frederick M Zasadny, Karen Jesus Oliveira, Karla Maria Pereira Pires, Angela Olvera, Jennifer Jeffers, Rhonda Souvenir, Rose Mcglauflin, Alec Seei, Trevor Funari, Hiromi Sesaki, Matthew J Potthoff, Christopher M Adams, Ethan J Anderson, E Dale Abel
Mitochondrial dynamics is a conserved process by which mitochondria undergo repeated cycles of fusion and fission, leading to exchange of mitochondrial genetic content, ions, metabolites, and proteins. Here, we examine the role of the mitochondrial fusion protein optic atrophy 1 (OPA1) in differentiated skeletal muscle by reducing OPA1 gene expression in an inducible manner. OPA1 deficiency in young mice results in non-lethal progressive mitochondrial dysfunction and loss of muscle mass. Mutant mice are resistant to age- and diet-induced weight gain and insulin resistance, by mechanisms that involve activation of ER stress and secretion of fibroblast growth factor 21 (FGF21) from skeletal muscle, resulting in increased metabolic rates and improved whole-body insulin sensitivity...
June 12, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28606915/baseline-circulating-fgf21-concentrations-and-increase-after-fenofibrate-treatment-predict-more-rapid-glycemic-progression-in-type-2-diabetes-results-from-the-field-study
#3
Kwok-Leung Ong, Rachel O'Connell, Andrzej S Januszewski, Alicia J Jenkins, Aimin Xu, David R Sullivan, Philip J Barter, Russell S Scott, Marja-Riitta Taskinen, Boris Waldman, Peter G Colman, James D Best, John R Simes, Kerry-Anne Rye, Anthony C Keech
BACKGROUND: It is not known whether circulating fibroblast growth factor 21 (FGF21) concentrations are associated with glycemic progression in patients with established type 2 diabetes. This study reports this relationship in type 2 diabetes patients participating in the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) trial. METHODS: Plasma FGF21 was quantified in 9697 study participants. Among patients with lifestyle-only glucose control measures at baseline, glycemic progression was defined as the initiation of oral hypoglycemic agents or insulin therapy...
June 12, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28593912/impact-of-fgf21-on-glycemic-control
#4
REVIEW
Mathias Z Strowski
Fibroblast growth factor 21 (FGF21) plays a role in regulating adaptation to various metabolic abnormalities. In addition, FGF21 is involved in controlling glucose and lipid homeostasis. The regulation of FGF21 is a complex process and depends upon multiple metabolic factors and hormones. Humans and animals with obesity or type 2 diabetes have abnormal expression and changes of FGF21 in the circulation. Interventional studies in rodents and monkeys with obesity, insulin resistance or type 2 diabetes revealed a potential therapeutic relevance of FGF21 in correcting these abnormalities...
June 3, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28591702/fgf21-functions-as-a-sensitive-biomarker-of-apap-treated-patients-and-mice
#5
Rong Li, Chao Guo, Xinmou Wu, Zhaoquan Huang, Jian Chen
Acetaminophen (APAP) is a common medication that induces hepatocellular damage in a time- or dose-dependent manner. Fibroblast growth factor 21 (FGF21) exerts a series of biological effects, including cellular repair. Compared to clinical diagnosis parameters, we aimed to evaluate whether FGF21 can serve as a sensitive biomarker for APAP-induced liver impairment. In the present study, we discussed comparable data from APAP-treated patients and parallelly established APAP-exposed mice for investigation. The resulting human serological data showed that APAP-treated patients have a visible reduction of FGF21 expression in undetected liver impairment of clinical diagnosis...
May 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28588304/plasma-fgf21-levels-in-obese-patients-undergoing-energy-restricted-diets-or-bariatric-surgery-a-marker-of-metabolic-stress
#6
A B Crujeiras, D Gomez-Arbelaez, M A Zulet, M C Carreira, I Sajoux, D de Luis, A I Castro, J Baltar, I Baamonde, A Sueiro, M Macias-Gonzalez, D Bellido, F J Tinahones, J A Martinez, F F Casanueva
CONTEXT: Fibroblast growth factor 21 (FGF21) has been suggested to be an endocrine signal of nutritional status and an active regulator of metabolism. However, there is no agreement on the effect of weight loss therapies on circulating levels of FGF21 in humans. OBJECTIVE: To assess FGF21 circulating levels in adiposity excess and after different weight loss strategies prescribed in five different groups from 4 independent centers. SUBJECTS AND METHODS: Body composition, ketosis, insulin sensitivity and FGF21 were evaluated in 181 excess body weight and 14 normal-weight subjects...
June 7, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28588097/high-intensity-interval-training-and-calorie-restriction-promote-remodeling-of-glucose-and-lipid-metabolism-in-diet-induced-obesity
#7
Rachel A H Davis, Jacob E Halbrooks, Emily Watkins, Gordon Fisher, Gary R Hunter, Tim R Nagy, Eric P Plaisance
Calorie restriction (CR) decreases adiposity, but the magnitude and defense of weight loss is less than predicted due to reductions in total daily energy expenditure (TEE). The purpose of the current investigation was to determine if high-intensity interval training (HIIT) would increase markers of sympathetic activation in white adipose tissue (WAT) and rescue CR-mediated reductions in EE to a greater extent than moderate-intensity aerobic exercise training (MIT). Thirty-two 5-wk old male C57BL/6J mice were placed on ad libitum HFD for 11 weeks followed by randomization to one of four groups (n = 8 per group) for an additional 15 weeks: 1) CON (remain on HFD); 2) CR (25% lower energy intake); 3) CR+HIIT (25% energy deficit created by 12...
June 6, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28588089/role-of-circulating-fibroblast-growth-factor-21-measurement-in-primary-prevention-of-coronary-heart-disease-among-chinese-patients-with-type-2-diabetes-mellitus
#8
Chi Ho Lee, Yu Cho Woo, Wing Sun Chow, Chloe Yu Yan Cheung, Carol Ho Yi Fong, Michele Mae Ann Yuen, Aimin Xu, Hung Fat Tse, Karen Siu Ling Lam
BACKGROUND: Fibroblast growth factor 21 (FGF21) has demonstrated beneficial effects on lipid and carbohydrate metabolism. In cross-sectional studies, an association of raised circulating FGF21 levels with coronary heart disease (CHD) was found in some but not all studies. Here we investigated prospectively whether baseline serum FGF21 levels could predict incident CHD in subjects with type 2 diabetes mellitus and no known cardiovascular diseases. METHODS AND RESULTS: Baseline serum FGF21 levels were measured in 3528 Chinese subjects with type 2 diabetes mellitus recruited from the Hong Kong West Diabetes Registry...
June 6, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28584524/fibroblast-growth-factor-21-deficiency-attenuates-experimental-colitis-induced-adipose-tissue-lipolysis
#9
Liming Liu, Cuiqing Zhao, Ying Yang, Xiaoxia Kong, Tuo Shao, Li Ren, Xinyu Zhuang, Baishuang Yin, Gerald Dryden, Craig McClain, Weimin Luan, Wenke Feng
AIMS: Nutrient deficiencies are common in patients with inflammatory bowel disease (IBD). Adipose tissue plays a critical role in regulating energy balance. Fibroblast growth factor 21 (FGF21) is an important endocrine metabolic regulator with emerging beneficial roles in lipid homeostasis. We investigated the impact of FGF21 in experimental colitis-induced epididymal white adipose tissue (eWAT) lipolysis. METHODS: Mice were given 2.5% dextran sulfate sodium (DSS) ad libitum for 7 days to induce colitis...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28582462/association-between-circulating-fibroblast-growth-factor-21-and-mortality-in-end-stage-renal-disease
#10
Marina Kohara, Takahiro Masuda, Kazuhiro Shiizaki, Tetsu Akimoto, Yuko Watanabe, Sumiko Honma, Chuji Sekiguchi, Yasuharu Miyazawa, Eiji Kusano, Yoshinobu Kanda, Yasushi Asano, Makoto Kuro-O, Daisuke Nagata
Fibroblast growth factor 21 (FGF21) is an endocrine factor that regulates glucose and lipid metabolism. Circulating FGF21 predicts cardiovascular events and mortality in type 2 diabetes mellitus, including early-stage chronic kidney disease, but its impact on clinical outcomes in end-stage renal disease (ESRD) patients remains unclear. This study enrolled 90 ESRD patients receiving chronic hemodialysis who were categorized into low- and high-FGF21 groups by the median value. We investigated the association between circulating FGF21 levels and the cardiovascular event and mortality during a median follow-up period of 64 months...
2017: PloS One
https://www.readbyqxmd.com/read/28580290/fgf21-resistance-is-not-mediated-by-downregulation-of-beta-klotho-expression-in-white-adipose-tissue
#11
Kathleen R Markan, Meghan C Naber, Sarah M Small, Lila Peltekian, Rachel L Kessler, Matthew J Potthoff
OBJECTIVE: Fibroblast growth factor 21 (FGF21) is an endocrine hormone that regulates metabolic homeostasis. Previous work has suggested that impairment of FGF21 signaling in adipose tissue may occur through downregulation of the obligate FGF21 co-receptor, β-klotho, which leads to "FGF21 resistance" during the onset of diet-induced obesity. Here, we sought to determine whether maintenance of β-klotho expression in adipose tissue prevents FGF21 resistance and whether other mechanisms also contribute to FGF21 resistance in vivo...
June 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/28580278/fgf21-does-not-require-adipocyte-amp-activated-protein-kinase-ampk-or-the-phosphorylation-of-acetyl-coa-carboxylase-acc-to-mediate-improvements-in-whole-body-glucose-homeostasis
#12
Emilio P Mottillo, Eric M Desjardins, Andreas M Fritzen, Vito Z Zou, Justin D Crane, Julian M Yabut, Bente Kiens, Derek M Erion, Adhiraj Lanba, James G Granneman, Saswata Talukdar, Gregory R Steinberg
OBJECTIVE: Fibroblast growth factor 21 (FGF21) shows great potential for the treatment of obesity and type 2 diabetes, as its long-acting analogue reduces body weight and improves lipid profiles of participants in clinical studies; however, the intracellular mechanisms mediating these effects are poorly understood. AMP-activated protein kinase (AMPK) is an important energy sensor of the cell and a molecular target for anti-diabetic medications. This work examined the role of AMPK in mediating the glucose and lipid-lowering effects of FGF21...
June 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/28576430/gastric-bypass-surgery-mimetic-approaches
#13
REVIEW
Brian R Boettcher
Gastric bypass surgery is effectively a polypharmacological approach for treatment of obesity, type 2 diabetes and nonalcoholic steatohepatitis (NASH). The gastric bypass mimetic approaches reviewed are fixed-dose combinatorial pharmacological approaches. There are two key concepts incorporated into these gastric bypass surgery mimetic approaches. The first key concept is that the combination of glucagon-like peptide 1 (GLP-1) and fibroblast growth factor 21 (FGF21) is essential for success of any gastric bypass surgery mimetic approach...
May 30, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28575427/corrigendum-for-diet-polyphenol-curcumin-stimulates-hepatic-fgf21-production-and-restores-its-sensitivity-in-high-fat-fed-male-mice
#14
(no author information available yet)
No abstract text is available yet for this article.
June 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28573777/once-weekly-administration-of-a-long-acting-fgf21-analogue-modulates-lipids-bone-turnover-markers-blood-pressure-and-body-weight-differently-in-obese-hypertriglyceridemic-subjects-and-in-non-human-primates
#15
Albert M Kim, Veena R Somayaji, Jennifer Q Dong, Timothy P Rolph, Yan Weng, Jeffrey R Chabot, Kathryn E Gropp, Saswata Talukdar, Roberto A Calle
AIMS: To assess the safety, tolerability, pharmacokinetics and pharmacodynamics of PF-05231023, a long-acting FGF21 analogue, in obese, hypertriglyceridemic subjects on atorvastatin with or without type 2 diabetes. METHODS: Subjects received PF-05231023 or placebo intravenously once-weekly for 4 weeks. Safety (12-lead electrocardiogram [ECGs], vital signs, adverse events [AEs], laboratory tests) and longitudinal weight assessments were performed. Blood samples were collected for pharmacokinetic and pharmacodynamic analyses...
June 1, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28559437/fibroblast-growth-factor-21-a-regulator-of-metabolic-disease-and-health-span
#16
Ting Xie, Po Sing Leung
Fibroblast growth factor 21 (FGF21) is a potent endocrine regulator with physiological effects on glucose and lipid metabolism and thus garners much attention on its translational potential for the management of obesity and related metabolic syndromes. FGF21 is mainly expressed in several metabolically active tissue organs, such as the liver, adipose tissue, skeletal muscle and pancreas with profound effects and therapeutically relevance. Emerging experimental and clinical data point to the demonstrated metabolic benefits of FGF21 which includes, but not limit to, weight loss, glucose and lipid metabolism as well as insulin sensitivity...
May 30, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28559436/hepatic-fgf21-mediates-gender-differences-in-high-fat-high-fructose-diet-induced-fatty-liver
#17
Natsasi Chukijrungroat, Tanaporn Khamphaya, Jittima Weerachayaphorn, Thaweesak Songserm, Vitoon Saengsirisuwan
The role of gender in the progression of fatty liver due to chronic high-fat, high-fructose diet (HFFD) has not been studied. The present investigation assessed whether HFFD induced hepatic perturbations differently between genders and examined the potential mechanisms. Male, female and ovariectomized (OVX) Sprague-Dawley rats were fed either control diet or HFFD for 12 weeks. Indices of liver damage and hepatic steatosis were analyzed biochemically and histologically together with monitoring changes in hepatic gene and protein expression...
May 30, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28559425/fgf21-ameliorates-diabetic-cardiomyopathy-by-activating-the-ampk-paraoxonase-1-signaling-axis-in-mice
#18
Fan Wu, Baile Wang, Saisai Zhang, Lihua Shi, Yanfang Wang, Rongrong Xiong, Xuebo Pan, Fanghua Gong, Xiaokun Li, Zhuofeng Lin
Aims: The aim in present study is to explore the molecular mechanism of FGF21 against diabetic cardiomyopathy. Materials and methods: FGF21 deficient mice and wild type littermates were used to induce diabetic mice by treatment with streptozotocin/high-fat diet (STZ/HFD), and then evaluated the difference of diabetic cardiomyopathy between two types of mice. Otherwise, primary cultured cardiomyocytes were also used to explore the potential molecular mechanism of FGF21 against high glucose-induced cardiomyocyte injuries...
May 30, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28554169/neohesperidin-exerts-lipid-regulating-effects-in-vitro-and-in-vivo-via-fibroblast-growth-factor-21-and-amp-activated-protein-kinase-sirtuin-type-1-peroxisome-proliferator-activated-receptor-gamma-coactivator-1%C3%AE-signaling-axis
#19
Haoshu Wu, Yunxi Liu, Xiaobing Chen, Difeng Zhu, Jian Ma, Youyou Yan, Meimei Si, Xian Li, Chongde Sun, Bo Yang, Qiaojun He, Kunsong Chen
The purpose of this study is to prove the lipid-regulating effects of neohesperidin (NHP) and explore the potential mechanisms related to fibroblast growth factor 21 (FGF21) and AMP-activated protein kinase (AMPK). Free fatty acids (FFAs)-induced lipid-accumulated HepG2 cells, acutely egg yolk-induced dyslipidemia and chronically diet-induced obese (DIO) model mice were treated with NHP. Biochemical analyses were carried out to determine the lipid profiles. Western blotting and real-time PCR were employed to analyze FGF21, AMPK and the related proteins or mRNA expressions...
May 30, 2017: Pharmacology
https://www.readbyqxmd.com/read/28552744/reduction-in-serum-fibroblast-growth-factor-21-after-gastric-bypass-is-related-to-changes-in-hepatic-fat-content
#20
Karen Fjeldborg, Steen B Pedersen, Holger J Møller, Bjørn Richelsen
BACKGROUND: Fibroblast growth factor 21 (FGF21) is elevated in obesity. OBJECTIVES: We investigated the circulating level of FGF21 and the expression of FGF21, beta-klotho (KLB), and FGF receptor 1 (FGFR1) in adipose tissue in relation to weight, fat distribution, and Roux-en-Y gastric bypass (RYGB)-induced weight loss. SETTING: The Department of Endocrinology at Aarhus University Hospital. METHODS: Thirty-one obese patients were enrolled...
April 7, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
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