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Vitamin c

Piotr Lodowski, Megan J Toda, Karolina Ciura, Maria Jaworska, Pawel M Kozlowski
Antivitamins B12 represent an important class of vitamin B12 analogues that have gained recent interest in several research areas. In particular, 4-ethylphenylcobalamin (EtPhCbl) and phenylethynylcobalamin (PhEtyCbl) exemplify two such antivitamins B12 which have been characterized structurally and chemically. From a spectroscopic point of view, EtPhCbl is photolabile with a very low quantum yield of photoproducts, while PhEtyCbl is incredibly photostable. Herein, DFT and TD-DFT computations are provided to explore the photolytic properties of these compounds to shed light on the electronic properties that are indicative of these differences...
June 18, 2018: Inorganic Chemistry
Marjorie L McCullough, Emilie S Zoltick, Stephanie J Weinstein, Veronika Fedirko, Molin Wang, Nancy R Cook, A Heather Eliassen, Anne Zeleniuch-Jacquotte, Claudia Agnoli, Demetrius Albanes, Matthew J Barnett, Julie E Buring, Peter T Campbell, Tess V Clendenen, Neal D Freedman, Susan M Gapstur, Edward L Giovannucci, Gary G Goodman, Christopher A Haiman, Gloria Y F Ho, Ronald L Horst, Tao Hou, Wen-Yi Huang, Mazda Jenab, Michael E Jones, Corinne E Joshu, Vittorio Krogh, I-Min Lee, Jung Eun Lee, Satu Männistö, Loic Le Marchand, Alison M Mondul, Marian L Neuhouser, Elizabeth A Platz, Mark P Purdue, Elio Riboli, Trude Eid Robsahm, Thomas E Rohan, Shizuka Sasazuki, Minouk J Schoemaker, Sabina Sieri, Meir J Stampfer, Anthony J Swerdlow, Cynthia A Thomson, Steinar Tretli, Schoichiro Tsugane, Giske Ursin, Kala Visvanathan, Kami K White, Kana Wu, Shiaw-Shyuan Yaun, Xuehong Zhang, Walter C Willett, Mitchel H Gail, Regina G Ziegler, Stephanie A Smith-Warner
Background: Experimental and epidemiological studies suggest a protective role for vitamin D in colorectal carcinogenesis, but evidence is inconclusive. Circulating 25-hydroxyvitamin D (25(OH)D) concentrations that minimize risk are unknown. Current Institute of Medicine (IOM) vitamin D guidance is based solely on bone health. Methods: We pooled participant-level data from 17 cohorts, comprising 5706 colorectal cancer case participants and 7107 control participants with a wide range of circulating 25(OH)D concentrations...
June 14, 2018: Journal of the National Cancer Institute
Cuiping Li, Weiyi Lai, Hailin Wang
Embryonic stem (ES) cells have the potential to differentiate into any of the three germ layers (endoderm, mesoderm, or ectoderm), and can generate many lineages for regenerative medicine. ES cell culture in vitro has long been the subject of widespread concerns. Classically, mouse ES cells are maintained in serum and leukemia inhibitory factor (LIF)-containing medium. However, under serum/LIF conditions, cells show heterogeneity in morphology and the expression profile of pluripotency-related genes, and are mostly in a metastable state...
June 1, 2018: Journal of Visualized Experiments: JoVE
Marc Escribà-Gelonch, Volker Hessel, Manuel C Maier, Timothy Noël, Maria Fernanda Neira d'Angelo, Heidrun Gruber-Woelfler
A continuous tandem in-line evaporation-crystallization is presented. The process includes an in-line solvent-swap step, suitable to be coupled to a capillary based cooler. As a proof of concept, this setup is tested in a direct in-line acetonitrile mediated crystallization of Vitamin D3 . This configuration is suitable to be coupled to a new end-to-end continuous microflow synthesis of Vitamin D3 . By this procedure, vitamin particles can be crystallized in continuous flow and isolated using an in-line continuous filtration step...
February 16, 2018: Organic Process Research & Development
Joshua H Guy, Grace E Vincent
Exercise-induced heat production is further elevated by exercise performed in hot conditions and this can subsequently impact inflammation, and gastrointestinal (GI) health. Implementing nutrition and supplementation strategies under these conditions may support the hyperthermic response, the systemic inflammatory response, GI permeability and integrity, and exercise performance. Therefore, the aim of this brief review is to explore athletes' inflammatory response of two key biomarkers, lipopolysaccharide (LPS), and interleukin-6 (IL-6), and provide nutrition and supplementation recommendations when exercising in hot conditions...
February 6, 2018: Sports (Basel)
K M Madder, J J McKinnon, G W Torres, K G Krone, J L Duncombe, C D Luby, F C Buchanan
Previous studies have shown that the interaction between limiting vitamin A (VA) and an alcohol dehydrogenase 1 C (ADH1C) variant in beef cattle results in increased intramuscular fat in the longissimus thoracis muscle in one genotype when fed low dietary VA. Although quality grade is important for increased profitability and improving taste characteristics of beef products, limiting VA too drastically can impair animal welfare. The objectives of this study were to determine if this marker-assisted management strategy would be effective, and whether any impairment in immune function would occur in a feedlot setting...
June 18, 2018: Animal: An International Journal of Animal Bioscience
Herbert J A Rolden, Gert Jan van der Wilt, Angela H E M Maas, Janneke P C Grutters
OBJECTIVES: As model-based economic evaluations (MBEEs) are widely used to make decisions in the context of policy, it is imperative that they represent clinical practice. Here, we assess the relevance of MBEEs on dabigatran for the prevention of stroke in patients with atrial fibrillation (AF). METHODS: We performed a systematic review on the basis of a developed questionnaire, tailored to oral anticoagulation in patients with AF. Included studies had a full body text in English, compared dabigatran with a vitamin K antagonist, were not dedicated to one or more subgroup(s), and yielded an incremental cost-effectiveness ratio...
June 18, 2018: International Journal of Technology Assessment in Health Care
Yueh-Ying Han, Erick Forno, Nadia Boutaoui, Glorisa Canino, Juan C Celedón
No abstract text is available yet for this article.
June 14, 2018: Annals of Allergy, Asthma & Immunology
Lili Chen, Zhengxiang He, Alina Cornelia Iuga, Sebastião N Martins Filho, Jeremiah J Faith, Jose C Clemente, Madhura Deshpande, Anitha Jayaprakash, Jean-Frederic Colombel, Juan J Lafaille, Ravi Sachidanandam, Glaucia C Furtado, Sergio A Lira
BACKGROUND & AIMS: Several studies have shown that signaling via the interleukin 23 (IL23) receptor is required for development of colitis. We studied the roles of IL23, dietary factors, alterations to the microbiota, and T cells in development and progression of colitis in mice. METHODS: All mice were maintained on lab diet 5053, unless otherwise noted. We generated mice that express IL23 in CX3CR1-positive myeloid cells (R23FR mice) upon cyclic administration of tamoxifen dissolved in diet 2019...
June 14, 2018: Gastroenterology
Nehuen Noacco, Boris Rodenak-Kladniew, Margarita García de Bravo, Guillermo R Castro, German A Islan
The development of simple, fast and reproducible techniques that provide information about the antioxidant activity (AA) of different compounds is essential to screen and discover new molecules with potential applications in the therapeutic, cosmetic, toxicological and food fields. Here, a novel and simple colorimetric method ("BCB assay") is proposed for measuring the AA of chemical compounds by protection of the reporter dye Brilliant Cresyl Blue (BCB) from loss of color due to oxidation by hypochlorite (a physiological oxidant)...
June 14, 2018: Analytical Biochemistry
John J Lima, Mario Castro, Tonya S King, Jason E Lang, Victor E Ortega, Stephen P Peters, Loren C Denlinger, Elliot Israel, Christine A Sorkness, Michael E Wechsler, Sally E Wenzel, Lewis J Smith
No abstract text is available yet for this article.
June 13, 2018: Annals of Allergy, Asthma & Immunology
Paulina Stolarek, Sylwia Różalska, Przemysław Bernat
Metarhizium robertsii, a butyltin-resistant filamentous fungus, can rapid and complete biodegradation of di- (DBT) and tributyltin (TBT) under conditions of intensive aeration and ascorbic acid supplementation. In this paper, lipidomic investigations were performed to find the membrane adaptations necessary for effective butyltins degradation. HPLC-MS/MS analysis showed that the phospholipid profile was greatly modified during M. robertsii batch cultivation (pO2  ≥ 20%), contributing to increased membrane fluidity and facilitated mass transfer, which could enhance butyltins biodegradation...
June 13, 2018: Biochimica et Biophysica Acta
Yuan Ru, Eva K Pressman, Ronnie Guillet, Philip J Katzman, Stephen J Bacak, Kimberly O O'Brien
BACKGROUND: Iron (Fe) status of neonates born to women carrying multiple fetuses might be compromised as a consequence of the high prevalence of maternal Fe deficiency and anemia coupled with an increased risk of preterm birth. This study aimed to characterize and identify determinants of anemia in this neonatal population. METHODS: Umbilical cord blood obtained from 183 neonates was utilized to assess hemoglobin (Hb), ferritin (SF), soluble transferrin receptor (sTfR), hepcidin, serum Fe, erythropoietin, folate, vitamin B-12, C-reactive protein, and interleukin-6...
June 15, 2018: Pediatric Research
Tomoka Fushimi, Tomonobu Uchino, Yasunori Miyazaki, Ichiro Hatta, Miyuki Asano, Hiyori Fujino, Rie Suzuki, Shun Fujimori, Daichi Kamiya, Yoshiyuki Kagawa
Phospholipid nanoparticles (PNs) encapsulating vitamin C and E derivatives, 3-O-cetyl ascorbic acid (CA) and tocopherol acetate (TA), respectively, were examined using the film rehydration and extrusion method. PN formulations (TA-Cassome) were prepared by mixing CA, soya phosphatidylcholine (Soya PC), sodium cholate, and TA at a molar ratio of 20/80/5/6. Glycerol (GL) or diglycerol (DG) were also added to improve the skin accumulation of CA and TA. Three TA-Cassome formulations were evaluated using a dynamic light scattering (DLS), NMR, TEM, skin accumulation test for CA and TA, and small-angle X-ray diffraction (SAXD) analysis...
June 12, 2018: International Journal of Pharmaceutics
John F Aloia, Melissa Fazzari, Shahidul Islam, Mageda Mikhail, Subhashini Katumuluwa, Ruban Dhaliwal, Alexandra Stolberg, Gianina Usera, Louis Ragolia
Black Americans have lower levels of serum 25(OH)D but superior bone health compared to white Americans. There is controversy over whether they should be screened for vitamin D deficiency and have higher vitamin D requirements than recommended by the Institute of Medicine (IOM). The purpose of this trial was to determine whether Vitamin D supplementation in elderly black women prevents bone loss. 260 healthy black American women, 60 years of age and older were recruited to take part in a two arm, double-dummy 3 year RCT of vitamin D3 vs...
June 15, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Jessica A Omand, Teresa To, Deborah L O'Connor, Patricia C Parkin, Catherine S Birken, Kevin E Thorpe, Jonathon L Maguire
BACKGROUND: Asthma is the most common chronic illness of childhood and a common reason for hospital admission. Studies suggest that low vitamin D levels may be associated with health service utilization (HSU) for childhood asthma. The primary objective was to determine if vitamin D serum levels in early childhood were associated with HSU for asthma including: a) hospital admissions; b) emergency department visits; and c) outpatient sick visits. Secondary objectives were to determine whether vitamin D supplementation in pregnancy or childhood were associated with HSU for asthma...
June 15, 2018: Pediatric Pulmonology
Robin Blythe, David Cook, Nicholas Graves
BACKGROUND: A sepsis care bundle of intravenous vitamin C, thiamine, and hydrocortisone was reported to improve treatment outcomes. The data to support it are uncertain and decision makers are likely to be cautious about adopting it. The objective of this study was to model the opportunity costs in dollars and lives of waiting for better information before adopting the bundle. METHODS: A decision tree was built using information from the literature. We modelled the impact of bundle adoption under three scenarios using a simulation in which the bundle was effective as reported in the primary trial, less effective based on other information, and ineffective...
2018: F1000Research
Jianli Lü, Wenzhi Zhao, Shengjie Tan, Pares Gerard Vinyes, Wenjun Li, Xiaoguang Yang, Peiyu Wang, Yumei Zhang
OBJECTIVE: To investigate micronutrients intake of pregnant women in 8 cities. METHODS: The multi-stage stratified cluster sampling method was applied in 8 cities( Beijing, Shanghai, Guangzhou, Lanzhou, Shenyang, Chengdu, Zhengzhou and Suzhou) from September 2011 to March 2012 to recruit healthy pregnant women, and then general information and dietary status were collected through face to face investigation. Nutrients intakes were calculated and analyzed then. RESULTS: There were 479 pregnantwomen in analysis, 58...
March 2018: Wei Sheng Yan Jiu, Journal of Hygiene Research
Tuerxunjiang Maimaitiming, Xiaojun Wang, Camila Tuerxunjiang, Yanqiong Yang, Dilihuomaer Wuerkaixi, Jinfen Pu, Li Wang, Liuqianzi Yan
OBJECTIVE: To understand the dietary intake situation of Uighur pregnant women, investigate folic acid level and its influencing factors, to provide evidence for health education of maternal nutrition and implementation of proper nutrition, balanceddiet guidance. METHODS: 358 cases of Uighur trimester pregnant women for the study, took the method of 3 d 24 h dietary recall to survey their dietary and collect blood samples. The Hb was detected by the cyanide methemoglobinmethod...
July 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
Yufeng Zhang, Liyun Zhao, Dongmei Yu
OBJECTIVE: To analyze the contribution of snacks to energy and nutrients among Chinese aged 6 and more in 2010-2012. METHODS: Using dietary data from the Chinese Nutrition and Health Surveillance in 2010-2012 to describe the intakes and percentages from sncaks of energy and nutrients. The 3-consecutive days-24-hour dietary recall and food weighting method were used to collect food, edible oil and condiment intake information. RESULTS: The average energy from snacks per capital per day of Chinese residents was 6...
July 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
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