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Vitamin c

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https://www.readbyqxmd.com/read/29040951/perfluoroalkyl-substances-bone-density-and-cardio-metabolic-risk-factors-in-obese-8-12-year-old-children-a-pilot-study
#1
Naila Khalil, James R Ebert, Masato Honda, Miryoung Lee, Ramzi W Nahhas, Antti Koskela, Thomas Hangartner, Kurunthachalam Kannan
BACKGROUND AND OBJECTIVE: Perfluoroalkyl substances (PFASs), including perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorohexane sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA), have been associated with adverse bone, and metabolic changes in adults. However association of PFASs with bone health in children is understudied. Considering their role as endocrine disruptors, we examined relationships of four PFASs with bone health in children. METHODS: In a cross sectional pilot study, 48 obese children aged 8-12 years were enrolled from Dayton's Children Hospital, Ohio...
October 14, 2017: Environmental Research
https://www.readbyqxmd.com/read/29040674/evaluation-of-apoptotic-and-autophagic-related-protein-expressions-before-and-after-in-vitro-maturation-of-fresh-slow-frozen-and-vitrified-pre-pubertal-mouse-testicular-tissue
#2
L Dumont, F Chalmel, A Oblette, B Berby, A Rives, V Duchesne, C Rondanino, N Rives
STUDY QUESTION: Do freezing and in vitro culture procedures enhance the expression of proteins involved in apoptotic or autophagic pathways in murine pre-pubertal testicular tissue? SUMMARY ANSWER: In vitro maturation strongly modified apoptosis- and autophagy-related relative protein levels in mice testicular tissue whereas the impact of cryopreservation procedures was minimal at the end of the culture. WHAT IS KNOWN ALREADY: In vitro spermatogenesis remains a challenging technical issue as it imposes to find a very close balance between survival and death of germ cell natural precursors (i...
October 11, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29040465/the-fut2-secretor-variant-p-trp154ter-influences-serum-vitamin-b12-concentration-via-holo-haptocorrin-but-not-holo-transcobalamin-and-is-associated-with-haptocorrin-glycosylation
#3
Aneliya Velkova, Jennifer E L Diaz, Faith Pangilinan, Anne M Molloy, James L Mills, Barry Shane, Erica Sanchez, Conal Cunningham, Helen McNulty, Cheryl D Cropp, Joan E Bailey-Wilson, Alexander F Wilson, Lawrence C Brody
Vitamin B12 deficiency is common in older individuals. Circulating vitamin B12 concentration can be used to diagnose deficiency but this test has substantial false positive and false negative rates. We conducted genome-wide association studies (GWAS) in which we resolved total serum vitamin B12 into the fractions bound to transcobalamin and haptocorrin: two carrier proteins with very different biological properties. We replicated reported associations between total circulating vitamin B12 concentrations and a common null variant in FUT2...
October 12, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29036958/-a-clinical-and-hereditary-analysis-of-novel-complex-heterozygous-kcnj1-mutation-in-a-bartter-syndrome-type-%C3%A2-patient
#4
X Y Li, Y Jiang, L J Xu, L Duan, X Y Peng, L M Chen, W B Xia, X P Xing
Bartter syndrome (BS) is a hereditary condition transmitted as an autosomal recessive (Bartter type 1 to 4) or dominant trait (Bartter type 5). The disease associates hypokalemic alkalosis with varying degrees of hypercalciuria. Here we presented a case (BS type Ⅱ) of a 17 years old female presented with polyhydramnios, polyuria, nephrocalcinosis and hypokalemia, which was alleviated after treatment with celecoxib and vitamin D(3). DNA sequencing identified compound heterozygous KCNJ1 gene mutations, c. 931C >T (p...
October 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29036893/development-and-validation-of-a-food-frequency-questionnaire-to-estimate-intake-among-children-and-adolescents-in-urban-peru
#5
Carly A Rodriguez, Emily R Smith, Eduardo Villamor, Nelly Zavaleta, Graciela Respicio-Torres, Carmen Contreras, Sara Perea, Judith Jimenez, Karen Tintaya, Leonid Lecca, Megan B Murray, Molly F Franke
Tools to assess intake among children in Latin America are limited. We developed and assessed the reproducibility and validity of a semi-quantitative food frequency questionnaire (FFQ) administered to children, adolescents, and their caregivers in Lima, Peru. We conducted 24-h diet recalls (DRs) and focus groups to develop a locally-tailored FFQ prototype for children aged 0-14 years. To validate the FFQ, we administered two FFQs and three DRs to children and/or their caregivers (N = 120) over six months. We examined FFQ reproducibility by quartile agreement and Pearson correlation coefficients, and validity by quartile agreement and correlation with DRs...
October 14, 2017: Nutrients
https://www.readbyqxmd.com/read/29034959/quantitative-proteomics-of-a-b12-dependent-alga-grown-in-coculture-with-bacteria-reveals-metabolic-tradeoffs-required-for-mutualism
#6
Katherine E Helliwell, Jagroop Pandhal, Matthew B Cooper, Joseph Longworth, Ulrich Johan Kudahl, David A Russo, Eleanor V Tomsett, Freddy Bunbury, Deborah L Salmon, Nicholas Smirnoff, Phillip C Wright, Alison G Smith
The unicellular green alga Lobomonas rostrata requires an external supply of vitamin B12 (cobalamin) for growth, which it can obtain in stable laboratory cultures from the soil bacterium Mesorhizobium loti in exchange for photosynthate. We investigated changes in protein expression in the alga that allow it to engage in this mutualism. We used quantitative isobaric tagging (iTRAQ) proteomics to determine the L. rostrata proteome grown axenically with B12 supplementation or in coculture with M. loti. Data are available via ProteomeXchange (PXD005046)...
October 16, 2017: New Phytologist
https://www.readbyqxmd.com/read/29034851/nitrosopumilus-maritimus-gen-nov-sp-nov-nitrosopumilus-cobalaminigenes-sp-nov-nitrosopumilus-oxyclinae-sp-nov-and-nitrosopumilus-ureiphilus-sp-nov-four-marine-ammonia-oxidizing-archaea-of-the-phylum-thaumarchaeota
#7
Wei Qin, Katherine R Heal, Rasika Ramdasi, Julia N Kobelt, Willm Martens-Habbena, Anthony D Bertagnolli, Shady A Amin, Christopher B Walker, Hidetoshi Urakawa, Martin Könneke, Allan H Devol, James W Moffett, E Virginia Armbrust, Grant J Jensen, Anitra E Ingalls, David A Stahl
Four mesophilic, neutrophilic, and aerobic marine ammonia-oxidizing archaea, designated strains SCM1(T), HCA1(T), HCE1(T) and PS0(T), were isolated from a tropical marine fish tank, dimly lit deep coastal waters, the lower euphotic zone of coastal waters, and near-surface sediment in the Puget Sound estuary, respectively. Cells are straight or slightly curved small rods, 0.15-0.26 µm in diameter and 0.50-1.59 µm in length. Motility was not observed, although strain PS0(T) possesses genes associated with archaeal flagella and chemotaxis, suggesting it may be motile under some conditions...
October 16, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29034199/cardioprotective-effects-of-achillea-wilhelmsii-on-the-isolated-rat-heart-in-ischemia-reperfusion
#8
M Mahmoudabady, M Lashkari, S Niazmand, M Soukhtanloo
CONTEXT: There are some reports about protective effects of Achillea on the heart. OBJECTIVE: We investigated the effect of Achillea wilhelmsii extract on cardiac function during ischemia-reperfusion (I/R) injury in the isolated rat heart. MATERIALS AND METHODS: 60 male Wistar rats were randomly divided into 6 groups; 1: Control group, 2: Control-ischemia (CI) 3: vitamin C (10 mg/kg), 4-6: Extract groups (E 100, E 200 and E 400 mg/kg). The animals received normal saline, vitamin C or A...
October 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29034175/refining-low-protein-modular-feeds-for-children-on-low-protein-tube-feeds-with-organic-acidaemias
#9
A Daly, S Evans, C Ashmore, S Chahal, S Santra, A MacDonald
Children with inherited metabolic disorders (IMD) who are dependent on tube feeding and require a protein restriction are commonly fed by 'modular tube feeds' consisting of several ingredients. A longitudinal, prospective two-phase study, conducted over 18 months assessed the long-term efficacy of a pre-measured protein-free composite feed. This was specifically designed to meet the non-protein nutritional requirements of children (aged over 1 year) with organic acidaemias on low protein enteral feeds and to be used as a supplement with an enteral feeding protein source...
December 2017: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/29030247/inhibition-of-intestinal-ascorbic-acid-uptake-by-lipopolysaccharide-is-mediated-via-transcriptional-mechanism-s
#10
Veedamali S Subramanian, Subrata Sabui, Hamid Moradi, Jonathan S Marchant, Hamid M Said
Ascorbic acid (AA) accumulation in intestinal epithelial cells is an active transport process mainly mediated by two sodium-dependent vitamin C transporters (SVCT-1 and SVCT-2). To date, little is known about the effect of gut microbiota generated lipopolysaccharide (LPS) on intestinal absorption of water-soluble vitamins. Therefore, the objective of this study was to investigate the effects of bacterially-derived LPS on AA homeostasis in enterocytes using Caco-2 cells, mouse intestine and intestinal enteroids models...
October 10, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29029732/determination-of-cyanocobalamin-by-isotope-dilution-lc-ms-ms
#11
Lucia D'Ulivo, Lu Yang, Jianfu Ding, Enea Pagliano, Donald M Leek, Marie-Pier Thibeault, Zoltán Mester
Cyanocobalamin (CNCbl) is an active form of vitamin B12, commonly employed for the preparation of multivitamin supplements and fortified food. In this study, we present a novel analytical method for its determination based on stable isotope dilution liquid chromatography electrospray tandem mass spectrometry (ID LC-MS/MS). Isotopically enriched (13)C(15)NCbl was synthesized in-house and used as internal standard. The method was validated using NIST SRM 3280 multivitamin reference material and by comparison with an independent methodology based on LC-ICPMS...
October 16, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29029621/uncertainty-on-the-effectiveness-and-safety-of-rivaroxaban-in-premenopausal-women-with-atrial-fibrillation-empirical-evidence-needed
#12
Herbert J A Rolden, Angela H E M Maas, Gert Jan van der Wilt, Janneke P C Grutters
BACKGROUND: Novel anticoagulations (NOACs) are increasingly prescribed for the prevention of stroke in premenopausal women with atrial fibrillation. Small studies suggest NOACs are associated with a higher risk of abnormal uterine bleeds than vitamin K antagonists (VKAs). Because there is no direct empirical evidence on the benefit/risk profile of rivaroxaban compared to VKAs in this subgroup, we synthesize available indirect evidence, estimate decision uncertainty on the treatments, and assess whether further research in premenopausal women is warranted...
October 13, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29029193/sex-and-iron-modify-fibroblast-growth-factor-23-fgf23-concentration-in-1-year-old-children
#13
Elisa Holmlund-Suila, Maria Enlund-Cerullo, Saara Valkama, Helena Hauta-Alus, Jenni Rosendahl, Otto Helve, Timo Hytinantti, Heli Viljakainen, Sture Andersson, Outi Mäkitie
Context: Fibroblast growth factor 23 (FGF23) plays an important role in phosphate homeostasis but its regulation is inadequately characterized. Objective: To examine regulators of FGF23, especially sex and iron status, in early childhood. Design: A cross-sectional study involving 1-year-old children. Setting and participants: Healthy term infants with a birth weight appropriate for gestational age were recruited to an ongoing vitamin D trial at the Kätilöopisto Maternity Hospital, Helsinki, Finland...
October 5, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29028831/short-term-vitamin-e-treatment-impairs-reactive-oxygen-species-signaling-required-for-adipose-tissue-expansion-resulting-in-fatty-liver-and-insulin-resistance-in-obese-mice
#14
Martin Alcala, Maria Calderon-Dominguez, Dolors Serra, Laura Herrero, Maria P Ramos, Marta Viana
OBJECTIVES: The use of antioxidant therapy in the treatment of oxidative stress-related diseases such as cardiovascular disease, diabetes or obesity remains controversial. Our aim is to demonstrate that antioxidant supplementation may promote negative effects if used before the establishment of oxidative stress due to a reduced ROS generation under physiological levels, in a mice model of obesity. METHODS: C57BL/6J mice were fed with a high-fat diet for 14 weeks, with (OE group) or without (O group) vitamin E supplementation...
2017: PloS One
https://www.readbyqxmd.com/read/29027975/dietary-supplement-use-during-preconception-the-australian-longitudinal-study-on-women-s-health
#15
Elle McKenna, Alexis Hure, Anthony Perkins, Ellie Gresham
Worldwide, dietary supplement use among reproductive aged women is becoming increasingly common. The aim of this study was to investigate dietary supplement use among Australian women during preconception. Self-reported data were collected prospectively for the Australian Longitudinal Study on Women's Health (ALSWH). The sample included 485 women aged 31-36 years, with supplement data, classified as preconception when completing Survey 5 of the ALSWH in 2009. Frequency and contingency tables were calculated and Pearson's chi-square test for associations between demographic variables and supplementation status was performed...
October 13, 2017: Nutrients
https://www.readbyqxmd.com/read/29027830/occurrence-types-properties-and-interactions-of-phenolic-compounds-with-other-food-constituents-in-oil-bearing-plants
#16
Muhammad H Alu'datt, Taha Rababah, Mohammad N Alhamad, Ghaid J Al-Rabadi, Carole C Tranchant, Ali Almajwal, Stan Kubow, Inteaz Alli
Phenolic phytochemicals have become of interest due to their therapeutic potential, particularly with regards to their anti-cancer, anti-inflammatory, hypolipidemic, and hypoglycemic properties. An evolving area of research involving phenolics in foods and their products pertains to the functional, biological, and nutritional consequences resulting from the binding between certain phenolic compounds and the macronutrient and micronutrient constituents of foods. The goal of this review is to provide a summary of studies investigating endogenous phenolic interactions with major components in food systems, including carbohydrates, proteins, lipids, minerals and vitamins, with a focus on the phenolic compounds and nutrients in oil-bearing plants...
October 13, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29027347/a-two-step-evolutionary-process-establishes-a-non-native-vitamin-b6-pathway-in-bacillus-subtilis
#17
Jonathan Rosenberg, KahYen C Yeak, Fabian M Commichau
Pyridoxal 5'-phosphate (PLP), the most important form of vitamin B6 serves as a cofactor for many proteins. Two alternative pathways for de novo PLP biosynthesis are known: the short deoxy-xylulose-5-phosphate (DXP)-independent pathway, which is present in the Gram-positive model bacterium Bacillus subtilis and the longer DXP-dependent pathway, which has been intensively studied in the Gram-negative model bacterium Escherichia coli. Previous studies revealed that bacteria contain many promiscuous enzymes causing a so-called "underground metabolism", which can be important for the evolution of novel pathways...
October 13, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/29026713/vitamin-c-induced-acute-kidney-injury
#18
Eun Hui Bae, Sung Sun Kim, Seong Kwon Ma, Soo Wan Kim
No abstract text is available yet for this article.
September 2017: Chonnam Medical Journal
https://www.readbyqxmd.com/read/29026589/a-retrospective-analysis-of-biochemical-and-haematological-parameters-in-patients-with-eating-disorders
#19
Leanne J Barron, Robert F Barron, Jeremy C S Johnson, Ingrid Wagner, Cameron J B Ward, Shannon R B Ward, Faye M Barron, Warren K Ward
BACKGROUND: The objective of the study was to determine whether levels of biochemical and haematological parameters in patients with eating disorders (EDs) varied from the general population. Whilst dietary restrictions can lead to nutritional deficiencies, specific abnormalities may be relevant to the diagnosis, pathogenesis and treatment of EDs. METHODS: With ethics approval and informed consent, a retrospective chart audit was conducted of 113 patients with EDs at a general practice in Brisbane, Australia...
2017: Journal of Eating Disorders
https://www.readbyqxmd.com/read/29026423/comprehensive-maternal-characteristics-associated-with-birth-weight-bayesian-modeling-in-a-prospective-cohort-study-from-iran
#20
Marjan Mansourian, Raziyeh Mohammadi, Hamid Reza Marateb, Akram Yazdani, Masoomeh Goodarzi-Khoigani, Sajedeh Molavi
BACKGROUND: In this study, we aimed to determine comprehensive maternal characteristics associated with birth weight using Bayesian modeling. MATERIALS AND METHODS: A total of 526 participants were included in this prospective study. Nutritional status, supplement consumption during the pregnancy, demographic and socioeconomic characteristics, anthropometric measures, physical activity, and pregnancy outcomes were considered as effective variables on the birth weight...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
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