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https://www.readbyqxmd.com/read/28173100/selective-right-atrial-cardioneuroablation-in-functional-atrioventricular-block
#1
Tolga Aksu, Erkan Baysal, Tumer Erdem Guler, Kıvanc Yalın
No abstract text is available yet for this article.
February 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28138399/rapid-identification-of-helicobacter-pylori-and-assessment-of-clarithromycin-susceptibility-from-clinical-specimens-using-fish
#2
Ebru Demiray-Gürbüz, Özlem Yılmaz, Asalia Z Olivares, Can Gönen, Sülen Sarıoğlu, Müjde Soytürk, Sait Tümer, Oğuz Altungöz, İlkay Şimşek, Guillermo I Perez Perez
Helicobacter pylori remains one of the most common bacterial infections worldwide. Clarithromycin resistance is the most important cause of H. pylori eradication failures. Effective antibiotic therapies in H. pylori infection must be rapidly adapted to local resistance patterns. We investigated the prevalence of clarithromycin resistance due to mutations in positions 2142 and 2143 of 23SrRNA gene of H. pylori by fluorescence in situ hybridisation (FISH), and compared with culture and antimicrobial susceptibility testing in 234 adult patients with dyspepsia who were enrolled...
January 2017: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/28106021/endocardial-septal-ablation-for-hypertrophic-obstructive-cardiomyopathy
#3
Tolga Aksu, Tümer Erdem Güler, Kıvanç Yalın, Şükriye Ebru Gölcük, Kazım Serhan Özcan
Septal reduction therapy (SRT) is the accepted therapeutic option for symptomatic hypertrophic obstructive cardiomyopathy (HOCM). At this time, surgical septal myectomy is the gold standard method, but alcohol septal ablation is an acceptable alternative treatment for patients with suitable anatomy. Endocardial septal ablation (ESA) therapy is a little-known method of SRT. Presently described is case of successful ESA procedure performed for HOCM.
January 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28106018/cardioneuroablation-in-the-treatment-of-neurally-mediated-reflex-syncope-a-review-of-the-current-literature
#4
Tolga Aksu, Tümer Erdem Güler, Serdar Bozyel, Kazım Serhan Özcan, Kıvanç Yalın, Ferit Onur Mutluer
OBJECTIVE: An imbalance between parasympathetic and sympathetic tone is a main cause of neurally mediated reflex syncope (NMRS). These patients may be very symptomatic and the condition may require cardiac pacemaker implantation. Cardioneuroablation (CNA) is a relatively novel technique based on radiofrequency ablation of vagal ganglia that can be used in treatment of NMRS. The aim of this analysis was to compare potential role of CNA in patients with NMRS. METHODS: In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement, literature search was conducted using the keywords "cardioneuroablation," "vagal denervation," "reflex syncope," "vagal ablation," and "ganglionic plexi ablation...
December 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28101772/zinc-deficiency-in-the-pediatric-age-group-is-common-but-underevaluated
#5
Dogus Vuralli, Leyla Tumer, Alev Hasanoglu
BACKGROUND: Subclinical micronutrient deficiencies have been gradually becoming more important as a public health problem and drawing attention of the health authorities. Today it has been known that detecting and treating people having deficiency symptoms alone is no longer sufficient. It is important to detect and prevent any deficiency before it displays clinical manifestations. Zinc deficiency is one of the most widespread micronutrient deficiencies. In this study, we aimed to evaluate the zinc status and the associated factors in healthy school-age children...
January 19, 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28051332/activation-of-the-central-melanocortin-system-chronically-reduces-body-mass-without-the-necessity-of-long-term-caloric-restriction
#6
I Côté, Y Sakarya, N Kirichenko, D Morgan, C S Carter, N Tümer, P J Scarpace
Melanotan II (MTII) is a potent appetite suppressor that rapidly reduces body mass. Given the rapid loss of anorexic response upon chronic MTII treatment, most investigations have focused on the initial physiological adaptations. However, other evidence supports MTII as a long-term modulator of energy balance that remains to be established. Therefore, we examined the chronic effects of MTII on energy homeostasis. MTII (high or low dose) or artificial cerebrospinal fluid (aCSF) was infused into the lateral ventricle of the brain of 6-month-old F344BN rats (6-7/group) over 40 days...
October 19, 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28007280/a-papillary-fibroelastoma%C3%A2-involving-aortic%C3%A2-and-pulmonary-valves-findings-on-multimodality-imaging
#7
Amir Ali Rahsepar, Ahmadreza Ghasemiesfe, Rahul N Sawlani, Marcos P Ferreira Botelho, Ajit S Paintal, Yanki Tumer, S Chris Malaisrie, Benjamin H Freed, Jeremy D Collins, James C Carr
Cardiac papillary fibroelastoma, a rare entity, is the second most common benign primary cardiac tumor. Commonly involving the cardiac valves, this entity is increasingly diagnosed using different imaging modalities. We present a rare case of simultaneous involvement of both the aortic and pulmonary valves in an asymptomatic patient who underwent different imaging modalities, including transthoracic and transesophageal echocardiography, nongated and gated computed tomography, and magnetic resonance imaging...
January 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28006433/intracerebroventricular-tempol-administration-in-older-rats-reduces-oxidative-stress-in-the-hypothalamus-but-does-not-change-stat3-signalling-or-sirt1-ampk-pathway
#8
Hale Z Toklu, Philip J Scarpace, Yasemin Sakarya, Nataliya Kirichenko, Michael Matheny, Erin B Bruce, Christy S Carter, Drake Morgan, Nihal Tümer
Hypothalamic inflammation and increased oxidative stress are believed to be mechanisms that contribute to obesity. 4-Hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl (tempol), a free radical scavenger, has been shown to reduce inflammation and oxidative stress. We hypothesized that brain infusion of tempol would reduce oxidative stress, and thus would reduce food intake and body weight and improve body composition in rats with age-related obesity and known elevated oxidative stress. Furthermore, we predicted an associated increase in markers of leptin signalling, including the silent mating type information regulator 2 homolog 1 (SIRT1)/5'AMP-activated protein kinase (AMPK) pathway and the signal transducer and activator of transcription 3 (STAT3) pathway...
January 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/27989786/malignant-tenosynovial-giant-cell-tumor-with-cdkn2a-b-genomic-alteration-a-histological-immunohistochemical-and-molecular-study
#9
Borislav A Alexiev, Yanki Tumer, Guang-Yu Yang
Diffuse-type tenosynovial giant cell tumor (D-T TSGCT) is regarded as a benign but locally aggressive neoplasm with significant recurrent potential. We report a case of malignant (D-T TSGCT with pleural metastases arising in the left knee in a 57-year-old male. The tumor demonstrated atypical features, including a solid infiltrative pattern with spindling of the tumor cells, nuclear pleomorphism with prominent nucleoli, and markedly increased mitotic activity (>20 mitoses/10 HPF). The immunoprofile demonstrated clusterin+, D2-40+, CD68+, p63+, MDM2+, p16- tumor...
December 15, 2016: Human Pathology
https://www.readbyqxmd.com/read/27988460/biological-evaluation-and-molecular-docking-studies-of-nitro-benzamide-derivatives-with-respect-to-in-vitro-anti-inflammatory-activity
#10
Tugba B Tumer, Ferah Comert Onder, Hande Ipek, Tugba Gungor, Seda Savranoglu, Tugba Taskin Tok, Ayhan Celik, Mehmet Ay
A series of nitro substituted benzamide derivatives were synthesized and evaluated for their potential anti-inflammatory activities in vitro. Firstly, all compounds (1-6) were screened for their inhibitory capacity on LPS induced nitric oxide (NO) production in RAW264.7 macrophages. Compounds 5 and 6 demonstrated significantly high inhibition capacities in a dose-dependent manner with IC50 values of 3.7 and 5.3μM, respectively. These two compounds were also accompanied by no cytotoxicity at the studied concentrations (max 50μM) in macrophages...
February 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/27970773/direct-cost-of-hiv-aids-in-turkey
#11
M Tatar, G Kockaya, B Ozelgun, T Zengin Elbir, A Senturk, E Tuna, S Unal, A Tumer, C Inkaya
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27970770/indirect-cost-of-hiv-aids-results-of-a-survey-from-a-turkish-research-center
#12
M Tatar, G Kockaya, B Ozelgun, T Zengin Elbir, A Senturk, E Tuna, S Unal, A Tumer, C Inkaya
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27920664/investigation-of-snp-rs2060546-immediately-upstream-to-ntn4-in-a-danish-gilles-de-la-tourette-syndrome-cohort
#13
Shanmukha S Padmanabhuni, Rayan Houssari, Ann-Louise Esserlind, Jes Olesen, Thomas M Werge, Thomas F Hansen, Birgitte Bertelsen, Fotis Tsetsos, Peristera Paschou, Zeynep Tümer
Gilles de la Tourette syndrome (GTS) is a neuropsychiatric disorder characterized by multiple motor and vocal tics. GTS is a complex disorder, with environmental factors and several genes involved. Although variations within a few genes such as AADAC, NRXN1, SLITRK1, HDC, and IMMP2L have been tentatively associated with GTS (in a small number of patients), the causative genes underlying GTS pathophysiology remain unknown. In a previous genome-wide association study (GWAS) a single nucleotide polymorphism (SNP, rs2060546) near the Netrin-4 (NTN4 - MIM 610401) gene was shown to be associated with GTS [odds ratio (OR) = 1...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27911167/recommendations-for-a-nomenclature-system-for-reporting-methylation-aberrations-in-imprinted-domains
#14
David Monk, Joannella Morales, Johan T den Dunnen, Silvia Russo, Franck Court, Dirk Prawitt, Thomas Eggermann, Jasmin Beygo, Karin Buiting, Zeynep Tümer
The analysis of DNA methylation has become routine in the pipeline for diagnosis of imprinting disorders, with many publications reporting aberrant methylation associated with imprinted differentially methylated regions (DMRs). However, comparisons between these studies are routinely hampered by the lack of consistency in reporting sites of methylation evaluated. To avoid confusion surrounding nomenclature, special care is needed to communicate results accurately, especially between scientists and other health care professionals...
December 2, 2016: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/27884419/a-novel-deep-inspiration-maneuver-for-difficult-transseptal-puncture
#15
Tolga Aksu, Tumer Erdem Guler, Kivanc Yalin, Sukriye Ebru Golcuk, Kazim Serhan Ozcan, Niyazi Guler
Transseptal puncture (TSP) may not be possible in cases of an elastic, aneurysmal, or thickened interatrial septum (IAS). During deep inspiration (DI), the chest wall expands and the diaphragm descends. This makes intrapleural pressure to become more negative, which leads to movement of the IAS to the right side. The aim of this study was to verify prospectively the feasibility, safety, and outcome of DI associated with conventional TSP technique in patients with challenging IAS anatomy. From September 2012 to May 2016, 224 patients underwent TSP due to different indications...
February 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/27875792/investigation-of-cd40-gene-rs4810485-and-rs1883832-mutations-in-patients-with-recurrent-aphthous-stomatitis
#16
Serbulent Yigit, Akin Tekcan, Aydin Rustemoglu, Mehmet Kemal Tumer, Goknur Kalkan, Kaan Yerliyurt
OBJECTIVES: Recurrent aphthous stomatitis (RAS) is a common painful disorder affecting oral health, mucosa and overall quality of life. The etiopathogenesis of RAS remains unclear. RAS shows a large genetic diversity among the patients. In present study, we investigated whether CD40 gene rs4810485 and rs1883832 are associated with RAS and its clinical findings in Turkish patients. MATERIALS AND METHODS: Genomic DNA obtained from 387 individuals (160 patients with RAS and 227 healthy controls) were used in the study...
February 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/27865293/septal-ablation-for-hypertrophic-obstructive-cardiomyopathy-transcoronary-and-endocardial-approach
#17
REVIEW
Tolga Aksu, Tumer Guler, Kivanc Yalin, Sukriye Ebru Golcuk, Kazim Ozcan
Septal reduction therapy is the gold standard treatment method for symptomatic, hypertrophic obstructive cardiomyopathy. Although surgical myectomy is a well-established and effective technique with decades of experience in its application, use of transcoronary alcohol septal ablation has increased precipitously owing to the less-invasive nature of the procedure. Moreover, endocardial septal ablation therapy is a relatively newly defined modality, and outcomes of the procedure are not clearly elucidated yet...
November 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27820421/cyp1b1-mutations-in-individuals-with-primary-congenital-glaucoma-and-residing-in-denmark
#18
Karen Grønskov, Alba Redó-Riveiro, Lisbeth Sandfeld, Nathalie Zibrandtsen, Pernille Harris, Daniella Bach-Holm, Zeynep Tümer
PURPOSE OF THE STUDY: Primary congenital glaucoma (PCG OMIM 231300) can be caused by pathogenic sequence variations in cytochrome P450, subfamily 1, polypeptide 1 (CYP1B1). The purpose of this study was to investigate the contribution of sequence variations in CYP1B1 in a cohort of individuals with PCG residing in Denmark. METHODS: The study included 37 unrelated individuals with PCG. Individuals were investigated for CYP1B1 mutations by Sanger sequencing of polymerase chain reaction products using BigDye terminators and capillary electrophoresis...
December 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/27639428/toxicity-of-ricin-a-chain-is-reduced-in-mammalian-cells-by-inhibiting-its-interaction-with-the-ribosome
#19
Amanda E Jetzt, Xiao-Ping Li, Nilgun E Tumer, Wendie S Cohick
Ricin is a potent ribotoxin that is considered a bioterror threat due to its ease of isolation and possibility of aerosolization. In yeast, mutation of arginine residues away from the active site results in a ricin toxin A chain (RTA) variant that is unable to bind the ribosome and exhibits reduced cytotoxicity. The goal of the present work was to determine if these residues contribute to ribosome binding and cytotoxicity of RTA in mammalian cells. The RTA mutant R193A/R235A did not interact with mammalian ribosomes, while a G212E variant with a point mutation near its active site bound ribosomes similarly to wild-type (WT) RTA...
November 1, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/27609434/role-of-endocardial-septal-ablation-in-the-treatment-of-hypertrophic-obstructive-cardiomyopathy
#20
Tolga Aksu, Tümer Erdem Güler, Kıvanç Yalın, Şükriye Ebru Gölcük, Kazım Serhan Özcan
Septal reduction therapy is accepted as a first therapeutic option for symptomatic drug-resistant hypertrophic obstructive cardiomyopathy (HOCM). Although, surgical septal myectomy is the gold standard method, alcohol septal ablation is a well-studied alternative approach in the patients with suitable anatomy. Endocardial septal ablation (ESA) therapy was relatively new defined modality and outcomes of the procedure were not clearly elucidated yet. We aimed to review the clinical aspects of ESA procedure and provide some historical background...
September 2016: Anatolian Journal of Cardiology
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