keyword
MENU ▼
Read by QxMD icon Read
search

Cholesterol

keyword
https://www.readbyqxmd.com/read/29356076/successful-management-of-steroid-resistant-vascular-tumors-associated-with-the-kasabach-merritt-phenomenon-using-sirolimus
#1
Xiaoyun Tan, Jing Zhang, Shaoyi Zhou, Zhenyin Liu, Tao Zhang, Jiejun Xia
Vascular tumors associated with Kasabach-Merritt phenomenon (KMP) are life-threatening and the mortality is as high as 10-30%. Steroids are considered the primary choice for drug therapy. However, there are many steroid-resistant cases. In the present study, analyzed data are presented to support the use of sirolimus in clinical practise for the treatment of corticosteroid-resistant vascular tumors with KMP in eight infants between June 2015 and April 2017 in a single hospital. The time to initial response was 6...
January 21, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29355907/e-learning-for-health-professionals
#2
REVIEW
Alberto Vaona, Rita Banzi, Koren H Kwag, Giulio Rigon, Danilo Cereda, Valentina Pecoraro, Irene Tramacere, Lorenzo Moja
BACKGROUND: The use of e-learning, defined as any educational intervention mediated electronically via the Internet, has steadily increased among health professionals worldwide. Several studies have attempted to measure the effects of e-learning in medical practice, which has often been associated with large positive effects when compared to no intervention and with small positive effects when compared with traditional learning (without access to e-learning). However, results are not conclusive...
January 21, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29355761/effects-of-dietary-spirulina-platensis-on-growth-performance-hematological-and-serum-biochemical-parameters-hepatic-antioxidant-status-immune-responses-and-disease-resistance-of-coral-trout-plectropomus-leopardus-lacepede-1802
#3
Wei Yu, Heizhao Lin, Yukai Yang, Xiaolin Huang, Chuanpeng Zhou, Zaiwang Zhang, Yafei Duan, Zhong Huang, Tao Li
The present study investigated the effects of dietary Spirulina platensis supplementation on growth performance, hematological and serum biochemical parameters, hepatic antioxidant status, immune responses and resistance to the pathogen infection in Coral trout Plectropomus leopardus. The fish were fed for 8-week with diets containing different levels of S. platensis: 0% (C), 2% (SP2), 4% (SP4), 6% (SP6), 8% (SP8) and 10% (SP10) as treatment groups, followed by a Vibrio harveyi infection test for 14 d. The study indicated that dietary supplementation with Spirulina platensis could significantly improve growth performance, and the highest weight gain rate (WGR) and specific growth rate (SGR) were observed in group SP10 (P < ...
January 17, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29355684/impact-of-adenosine-a2a-receptor-polymorphism-rs5751876-on-platelet-reactivity-in-ticagrelor-treated-patients
#4
Matteo Nardin, Monica Verdoia, Patrizia Pergolini, Roberta Rolla, Lucia Barbieri, Paolo Marino, Giorgio Bellomo, Elvin Kedhi, Harry Suryapranata, Alessandro Carriero, Giuseppe De Luca
Dual antiplatelet therapy constitutes a key point in the management of patients with acute coronary syndromes. In particular, ticagrelor, an ADP-antagonist, can provide a more potent and predictable platelet inhibition as compared to clopidogrel, and adenosine-mediated pathways have been involved in its beneficial effects on mortality and myocardial perfusion. However, a quote of patients still displays a suboptimal platelet inhibition on ticagrelor, and, while the role of genetics in conditioning clopidogrel resistance is well established, few data have been reported for ticagrelor...
January 17, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29355561/ameliorating-effects-of-d-47-a-newly-developed-compound-on-lipid-metabolism-in-an-animal-model-of-familial-hypercholesterolemia-whhlmi-rabbits
#5
Shohei Tamura, Yui Koike, Hiroaki Takeda, Tomonari Koike, Yoshihiro Izumi, Ryosuke Nagasaka, Tetsuto Tsunoda, Motoo Tori, Kazuo Ogawa, Takeshi Bamba, Masashi Shiomi
Improvements induced in lipid metabolism in the liver by D-47, a newly developed compound, were examined herein. WHHLMI rabbits, an animal model of hypercholesterolemia and coronary atherosclerosis, was fed D-47-supplemented chow for 5 weeks at a dose of 30mg/kg. Lipid concentration were assayed using enzymatic methods. Plasma lipoproteins were fractionated with an ultracentrifuge. mRNA expression was analyzed with real-time PCR. Lipidome analyses of lipoproteins were performed using supercritical fluid chromatography mass spectrometry...
January 16, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29355536/a-mathematical-model-of-the-mevalonate-cholesterol-biosynthesis-pathway
#6
Frances Pool, Richard Currie, Peter K Sweby, José Domingo Salazar, Marcus J Tindall
We formulate, parameterise and analyse a mathematical model of the mevalonate pathway, a key pathway in the synthesis of cholesterol. Of high clinical importance, the pathway incorporates rate limiting enzymatic reactions with multiple negative feedbacks. In this work we investigate the pathway dynamics and demonstrate that rate limiting steps and negative feedbacks within it act in concert to tightly regulate intracellular cholesterol levels. Formulated using the theory of nonlinear ordinary differential equations and parameterised in the context of a hepatocyte, the governing equations are analysed numerically and analytically...
January 17, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29355517/eicosapentaenoic-acid-and-docosahexaenoic-acid-have-distinct-membrane-locations-and-lipid-interactions-as-determined-by-x-ray-diffraction
#7
Samuel C R Sherratt, R Preston Mason
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) differentially influence lipid oxidation, signal transduction, fluidity, and cholesterol domain formation, potentially due in part to distinct membrane interactions. We used small angle x-ray diffraction to evaluate the EPA and DHA effects on membrane structure. Membrane vesicles composed of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and cholesterol (C) (0.3C:POPC mole ratio) were prepared and treated with vehicle, EPA, or DHA (1:10 mole ratio to POPC)...
January 17, 2018: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/29355488/smith-lemli-opitz-syndrome-in-a-newborn-infant-with-developmental-abnormalities-and-low-endogenous-cholesterol
#8
Yifei Yang, Lindsay Yassan, Edward Ki Yun Leung, Kiang-Teck J Yeo
BACKGROUND: Patients with Smith-Lemli-Opitz Syndrome (SLOS) have defective endogenous cholesterol synthesis, and present with decrease cholesterol levels and multiple developmental dysmorphologies. CASE DESCRIPTION: A newborn infant with normal XY karyotype and normal microarray was born with multiple developmental defects and ambiguous genitalia was diagnosed following biochemical genetic analysis of serum 7-DHC concentrations. The clinical course of the patient was further complicated by the comorbidities associated with SLOS and the bacterial infections...
January 16, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29355393/burden-and-management-of-noncommunicable-diseases-after-earthquakes-and-tsunamis
#9
Amit Suneja, Maxim Gakh, Lainie Rutkow
This integrative review examines extant literature assessing the burden and management of noncommunicable diseases 6 months or more after earthquakes and tsunamis. We conducted an integrative review to identify and characterize the strength of published studies about noncommunicable disease-specific outcomes and interventions at least 6 months after an earthquake and/or tsunami. We included disasters that occurred from 2004 to 2016. We focused primarily on the World Health Organization noncommunicable disease designations to define chronic disease, but we also included chronic renal disease, risk factors for noncommunicable diseases, and other chronic diseases or symptoms...
January 22, 2018: Health Security
https://www.readbyqxmd.com/read/29354959/-effect-of-acupuncture-on-macrophage-polarization-of-white-adipose-tissue-in-obese-mice-induced-by-high-fat-diet
#10
Siyi Zhang, Xia Hu, Hongtu Tang
OBJECTIVE: To observe the effect of acupuncture at acupoints and non-acupoints on macrophage polarization of white adipose tissue in obese mice induced by high-fat diet(HFD). METHODS: Fifty male C57BL/6 mice were randomly divided into a control group (n=10), and other mice were fed with HFD for 16 weeks to establish model. Thirty model mice, which were successfully established and continuously fed with HFD for 8 weeks, were randomized into a model group, a non-acupoint group and an acupuncture group (n=10/group)...
November 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29354930/-skin-needle-embedding-for-obese-impaired-glucose-tolerance
#11
Jinghua Liang, Zhendi Feng, Shengkui Feng, Shude Bao, Kejia Wang
OBJECTIVE: To explore the effect difference between the skin needle embedding therapy and western medication for obese impaired glucose tolerance (IGT). METHODS: A total of 300 cases of obese IGT were assigned into an embedding group and a western medication group by random number table, 150 cases in each one. Standardized diagnosis and treatment programs were applied to reduce blood pressure, lipid, weight, and exercise and scientific diet management were used...
January 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29354226/cardiovascular-risk-factors-and-cognitive-performance-in-aging
#12
Juliana Rumy Tsuchihashi Takeda, Tatiane Martins Matos, Juliana Nery de Souza-Talarico
Background: Atherosclerosis in cerebral blood vessels, especially those which compose the Circle of Willis, can lead to reduced supply of oxygen and nutrients to different cortical structures, affecting cognitive function. Objective: To analyze whether cardiovascular risk factors negatively influence cognitive performance in adults and elderly. Methods: One hundred twenty-nine participants of both sexes, aged over 50 years, without cognitive or functional impairment were included...
October 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29353827/oral-fat-tolerance-test-for-sitosterolemia-and-familial-hypercholesterolemia-a-study-protocol
#13
Akihiro Nomura, Hayato Tada, Atsushi Nohara, Masa-Aki Kawashiri, Masakazu Yamagishi
AIM: Sitosterolemia is an extremely rare, autosomal recessive disease characterized by high plasma cholesterols and plant sterols because of increased absorption of dietary cholesterols and sterols from the intestine, and decreased excretion from biliary tract. Previous study indicated that sitosterolemic patients might be vulnerable to post-prandial hyperlipidemia, including high remnant-like lipoprotein particles (RLP) level. Here we evaluate whether a loading dietary fat increases a post-prandial RLP cholesterol level in sitosterolemic patients compared to heterozygous familial hypercholesterolemic patients (FH)...
January 20, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29353825/treatment-patterns-and-lipid-profile-in-patients-with-familial-hypercholesterolemia-in-japan
#14
Tamio Teramoto, Takahito Kai, Asuka Ozaki, Bruce Crawford, Hidenori Arai, Shizuya Yamashita
AIM: To evaluate the epidemiology and real-world treatment patterns associated with lipid-modifying therapies (LMTs) among groups of Japanese patients with familial hypercholesterolemia (FH). METHODS: A retrospective observational study was conducted using an electronic hospital-based administrative claims database and electronic medical records. Patients with existing diagnosis of FH (FH-D) and patients with suspected FH (FH-S) defined by low-density lipoprotein cholesterol (LDL-C) ≥190 mg/dL were included, and medical records of hospitals across Japan were analyzed to assess the diagnostic status, management of LDL-C levels, and treatment patterns...
January 19, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29353811/statin-wars-have-we-been-misled-about-the-evidence-a-narrative-review
#15
REVIEW
Maryanne Demasi
Statins are the most widely prescribed, cholesterol-lowering drugs in the world. Despite the expiration of their patents, revenue for statins is expected to rise, with total sales on track to reach an estimated US$1 trillion by 2020. A bitter dispute has erupted among doctors over suggestions that statins should be prescribed to millions of healthy people at low risk of heart disease. There are concerns that the benefits have been exaggerated and the risks have been underplayed. Also, the raw data on the efficacy and safety of statins are being kept secret and have not been subjected to scrutiny by other scientists...
January 21, 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29353699/near-infrared-heat-lamp-therapeutic-effect-on-paraoxonase-1-and-myeloperoxidase-as-potential-biomarkers-of-redox-state-changes-induced-by-%C3%AE-irradiation-in-albino-rats
#16
N Abdel-Magied, A G Ahmed, S M Shedid
Infrared radiation has a potential therapeutic effect in some diseases. The aim of this study was to estimate the therapeutic role of near infrared heat lamp (NIRHL) on the variations of the activity of paraoxonase 1 (PON1) and myeloperoxidase (MPO), in relation to lipid disorders, associated with oxidative stress in rats gamma-irradiated. In addition, study the effect of the duration of NIRHL treatment. Animals were divided into six groups. The results revealed that irradiated rats treated with NIRHL 20 min/once/day showed positive modulation of PON1 and MPO linked to significant improvement of lipid disorders evidenced by lower triglycerides, low density lipoprotein cholesterol (LDL-C), oxidized low density lipoprotein cholesterol (oxLDL-C) and higher density lipoprotein cholesterol (HDL-C) as well as significant amelioration of redox state, manifested by markedly increase of glutathione (GSH) content, total antioxidant capacity (TAC) associated with a noticeable decrease of pro-inflammatory cytokines...
January 16, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29353693/multiscale-molecular-dynamics-simulations-of-lipid-interactions-with-p-glycoprotein-in-a-complex-membrane
#17
Laura Domicevica, Heidi Koldsø, Philip C Biggin
P-glycoprotein (P-gp) can transport a wide range of very different hydrophobic organic molecules across the membrane. Its ability to extrude molecules from the cell creates delivery problems for drugs that target proteins in the central nervous system (CNS) and also causes drug-resistance in many forms of cancer. Whether a drug will be susceptible to export by P-gp is difficult to predict and currently this is usually assessed with empirical and/or animal models. Thus, there is a need to better understand how P-gp works at the molecular level in order to fulfil the 3Rs: Refinement, reduction and replacement of animals in research...
December 30, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29353502/-the-labyrinth-of-residual-risk-reduction-of-the-remaining-lipid-and-inflammation-risk-in-the-prevention-of-atherosclerosis
#18
László Márk, Mariann Harangi, György Paragh
Since cardiovascular diseases are the main cause of mortality worldwide, the reduction of their risk is a crucial point of present-day medicine. It has been proven unequivocally that the administration of various treatments has a favorable effect on the frequency of cardiovascular events and on the atherosclerosis leading to them. Although systematic and guideline-driven administration of these drugs has led to a decrease in the incidence and mortality of vascular events, the leading position of this group of diseases in mortality and morbidity has not changed...
January 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29353414/oral-administration-of-compound-probiotics-ameliorates-hfd-induced-gut-microbe-dysbiosis-and-chronic-metabolic-inflammation-via-the-g-protein-coupled-receptor-43-in-non-alcoholic-fatty-liver-disease-rats
#19
Yinji Liang, Shu Liang, Yupei Zhang, Yuanjun Deng, Yifang He, Yanning Chen, Chan Liu, Chenli Lin, Qinhe Yang
The aim of this study was to investigate how the effects of compound probiotics modulate the gut microbiota, short-chain fatty acid (SCFA), body composition, serum and liver lipids, and inflammatory markers in non-alcoholic fatty liver disease (NAFLD) rats. Twenty-four male SD rats were randomly divided into 3 groups: normal control group (standard feed), high-fat diet (HFD) feeding group (83% standard feed + 10% lard oil + 1.5% cholesterol + 0.5% cholate + 5% sucrose), and compound probiotics intervention group (HFD + 0...
January 20, 2018: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29353350/clinical-pharmacokinetics-and-pharmacodynamics-of-evolocumab-a-pcsk9-inhibitor
#20
REVIEW
Sreeneeranj Kasichayanula, Anita Grover, Maurice G Emery, Megan A Gibbs, Ransi Somaratne, Scott M Wasserman, John P Gibbs
Proprotein convertase subtilisin/kexin type 9 (PCSK9) increases plasma low-density lipoprotein cholesterol (LDL-C) by decreasing expression of the LDL receptor on hepatic cells. Evolocumab is a human monoclonal immunoglobulin G2 that binds specifically to human PCSK9 to reduce LDL-C. Evolocumab exhibits nonlinear kinetics as a result of binding to PCSK9. Elimination is predominantly through saturable binding to PCSK9 at lower concentrations and a nonsaturable proteolytic pathway at higher concentrations. The effective half-life of evolocumab is 11-17 days...
January 20, 2018: Clinical Pharmacokinetics
keyword
keyword
1875
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"