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https://www.readbyqxmd.com/read/29793176/non-ldl-dyslipidemia-is-prevalent-in-the-young-and-determined-by-lifestyle-factors-and-age-the-lifelines-cohort
#1
Jeroen K de Vries, Jan W Balder, Michelle J Pena, Petra Denig, Andries J Smit
BACKGROUND AND AIMS: Non-LDL dyslipidemia (NLD) confers cardiovascular risk, and prevalence rates appear to be high in elderly populations. Small cohorts have identified several lifestyle, anthropometric, and medical factors associated with NLD. We aimed to assess sex- and age-specific prevalence of NLD in a contemporary population cohort (n = 167 729), and to identify independent determinants of NLD, focusing on lifestyle, anthropometric, and medical factors. METHODS: The prevalence of NLD was assessed per 10-year age intervals in adults without cardiovascular disease not using lipid-modifying drugs from the Dutch LifeLines cohort...
May 21, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29793168/olive-oil-polyphenols-reduce-oxysterols-induced-redox-imbalance-and-pro-inflammatory-response-in-intestinal-cells
#2
Gessica Serra, Alessandra Incani, Gabriele Serreli, Laura Porru, M Paola Melis, Carlo I G Tuberoso, Daniela Rossin, Fiorella Biasi, Monica Deiana
Dietary habits may strongly influence intestinal homeostasis. Oxysterols, the oxidized products of cholesterol present in cholesterol-containing foodstuffs, have been shown to exert pro-oxidant and pro-inflammatory effects, altering intestinal epithelial layer and thus contributing to the pathogenesis of human inflammatory bowel diseases and colon cancer. Extra virgin olive oil polyphenols possess antioxidant and anti-inflammatory properties, and concentrate in the intestinal lumen, where may help in preventing intestinal diseases...
May 16, 2018: Redox Biology
https://www.readbyqxmd.com/read/29792483/when-anger-expression-might-be-beneficial-for-african-americans-the-moderating-role-of-chronic-discrimination
#3
Jiyoung Park, Abdiel J Flores, Kirstin Aschbacher, Wendy Berry Mendes
OBJECTIVES: Anger expression is assumed to have mostly negative health effects. Yet, evidence is mixed on how anger expression influences African Americans' cardiovascular health. The present research aimed to clarify this link by examining moderating effects of chronic discrimination on the relationship between anger expression and cardiovascular risk among African Americans in experimental (Study 1) and epidemiological (Study 2) studies. METHOD: Study 1 examined how African Americans' trait anger expression was linked to (a) physiologic reactivity to acute social rejection during an interracial encounter (Session 1); and (b) total/HDL cholesterol assessed two months later (Session 2)...
May 24, 2018: Cultural Diversity & Ethnic Minority Psychology
https://www.readbyqxmd.com/read/29792387/resveratrol-prevents-high-calorie-diet-induced-learning-and-memory-dysfunction-in-juvenile-c57bl-6j-mice
#4
Bao-Lei Xu, Hui Zhang, Li-Na Ma, Wen Dong, Zhi-Wei Zhao, Jing-Shuang Zhang, Yu-Lan Wang, Xu Zhang, Rong Wang
OBJECTIVE: Because resveratrol (RSV) has been shown to improve learning and memory, so we investigated the potential benefit of RSV on learning and memory deficits in juvenile mice fed with a HC diet and explored the molecular mechanisms underlying this process. METHODS: Six-week-old C57BL/6J mice were divided into three different diet groups: control, HC diet, and HC + RSV diet. Serum insulin and insulin-like growth factor 1 (IGF-1) levels were measured using enzyme-linked immunosorbent assays...
May 24, 2018: Neurological Research
https://www.readbyqxmd.com/read/29792380/alirocumab-as-add-on-therapy-to-statins-current-evidence-and-clinical-potential
#5
Johann Auer, Robert Berent
Atherosclerotic cardiovascular diseases (ASCVDs) are associated with a substantial mortality, physical morbidity, and mental disability. Elevated plasma low-density lipoprotein cholesterol (LDL-C) levels play a major role in the pathophysiology of ASCVDs. Statins have been shown to reduce ASCVD risk and associated events and are recommended as first-line therapy for treatment of hypercholesterolemia by current international guidelines. The key issue is to attain guideline-recommended LDL-C levels (below 70 mg/dl) for patients at very high cardiovascular risk...
May 1, 2018: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/29792269/pcsk9-inhibition-ready-for-prime-time-in-ckd
#6
Marion Mafham, Richard Haynes
Lowering LDL cholesterol reduces the risk of atherosclerotic vascular disease in a wide range of patients with chronic kidney disease, with no evidence of a threshold below which further reductions no longer reduce risk. Statins safely lower LDL cholesterol, but novel inhibitors of proprotein convertase subtilisin kexin 9 (PCSK9) provide additional reductions which may reduce atherosclerotic vascular disease yet further in this high risk population.
June 2018: Kidney International
https://www.readbyqxmd.com/read/29792202/the-effects-of-a-lifestyle-focused-text-messaging-intervention-on-adherence-to-dietary-guideline-recommendations-in-patients-with-coronary-heart-disease-an-analysis-of-the-text-me-study
#7
Karla Santo, Karice Hyun, Laura de Keizer, Aravinda Thiagalingam, Graham S Hillis, John Chalmers, Julie Redfern, Clara K Chow
BACKGROUND: A healthy diet is an important component of secondary prevention of coronary heart disease (CHD). The TEXT ME study was a randomised clinical trial of people with CHD that were randomised into standard care or a text-message programme in addition to standard care. This analysis aimed to: 1) assess the effects of the intervention onadherence to the dietary guideline recommendations; 2) assess the consistency of effect across sub-groups; and 3) assess whether adherence to the dietary guideline recommendations mediated the improvements in objective clinical outcomes...
May 23, 2018: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/29792133/impact-of-collaborative-shared-medical-appointments-on-diabetes-outcomes-in-a-family-medicine-clinic
#8
Melody L Hartzler, McKenzie Shenk, Julie Williams, James Schoen, Thomas Dunn, Douglas Anderson
Purpose The purpose of this study is to evaluate the impact of a collaborative diabetes shared medical appointment on patient outcomes in an urban family medicine practice. Methods Fifty-nine patients were enrolled to participate in multiple shared medical appointments (SMAs) over 12 months. Baseline data included hemoglobin (A1C), lipids, systolic blood pressure (SBP), weight, adherence to American Diabetes Association (ADA) guidelines, and surveys, including the Problem Areas in Diabetes (PAID-2) scale and the Spoken Knowledge in Low Literacy in Diabetes Scale (SKILLD)...
May 1, 2018: Diabetes Educator
https://www.readbyqxmd.com/read/29791983/-management-of-gallstone
#9
REVIEW
Kyo Sang Yoo
Gallstones are one of the most common diseases worldwide. Recently, the incidence of gallstones has increased and the pattern of gallstones has changed in Korea. Laparoscopic cholecystectomy is the standard treatment for symptomatic gallstones. Expectant management is considered the most appropriate choice in patients with asymptomatic gallstones. The dissolution of cholesterol gallstones by oral bile acid, such as ursodeoxycholic acid, can be considered in selected patients with gallstones. Although the advent of laparoscopic cholecystectomy has moved interest away from the pharmacologic treatment of gallstones, several promising agents related to various mechanisms are under investigation...
May 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29791572/is-lipid-accumulation-product-associated-with-an-atherogenic-lipoprotein-profile-in-brazilian-subjects
#10
Flavia De Conti Cartolano, Caroline Pappiani, Maria Camila Prupper de Freitas, Antonio M Figueiredo Neto, Antônio Augusto Ferreira Carioca, Nágila Raquel Teixeira Damasceno
BACKGROUND: Lipid accumulation product (LAP), a simple and low-cost tool, is a novel biomarker of central lipid accumulation and represents a potential surrogate marker for atherogenic lipoprotein profile. However, its association with lipoprotein subfractions has not been described in the literature. OBJECTIVE: To determine whether LAP index could be used as a marker of low- and high-density lipoprotein (LDL and HDL) size in Brazilian individuals. METHODS: This cross-sectional study included patients (n = 351) of both sexes and age between 30-74 years...
April 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29791465/predictors-of-subclinical-carotid-atherosclerosis-in-middle-aged-women
#11
Isly L de Barros, Laura Costa, Bento Bezerra, Rafael Gomes, Natanael Morais, Célia M C Strunz, Moacir Novaes, Otávio C E Gebara, Rodrigo Pinto Pedrosa, José C Nicolau
BACKGROUND: Traditional strategies for primary cardiovascular prevention have been insufficient in reducing the high rates of coronary ischemic events in women, probably because these women are often stratified into low-risk groups. However, cardiovascular diseases continue to be the main cause of morbidity and mortality in women worldwide. We hypothesized that carotid atherosclerosis (CA) is common in middle-aged women. METHODS: We prospectively evaluated asymptomatic peri- and post-menopausal women with no cardiovascular diseases or the use of hormone therapy from two gynecologic clinics...
2018: PloS One
https://www.readbyqxmd.com/read/29791175/-dyslipidemia-and-hypertension-what-to-worry-about-more
#12
Jan Václavík
Dyslipidemia is present in every other patient with arterial hypertension. With increasing blood pressure and cholesterol levels, the risk of cardiovascular events increases proportionally. Treatment of dyslipidemia appears to lower cardiovascular mortality to a greater extent than treatment of hypertension. A significant proportion of patients with dyslipidemia indicated for drug therapy are not treated at all or treated insufficiently and do not reach the target values. Concurrent treatment of hypertension and dyslipidemia reduces the incidence of cardiovascular events significantly more than treating only one of these diseases...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29791169/-epicardial-fat-and-osteoprotegerin-does-a-mutual-relation-exist-pilot-study
#13
Markéta Sovová, Eliška Sovová, Jana Zapletalová, Markéta Kaletová, David Stejskal, Milan Sova, Michal Konečný, Vlastimil Procházka, Drahomíra Vrzalová, Lea Zarivnijová
INTRODUCTION: Epicardial fat (EPI) plays important role in development of metabolic and cardiovascular diseases. According to population studies EPI represents independent risk factor of cardiovascular diseases (CVD) and also for neoplasms. Osteoprotegerin (OPG) is a glycoprotein which have role in regulation of immune and cardiovascular systems. High serum levels of OPG are connected with high cardiovascular risk. The aim of our study was to evaluate possible correlation between EPI and OPG level in asymptomatic relatives of patients with CVD...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29791146/effect-of-cholesterol-on-membrane-dipole-potential-atomistic-and-coarse-grained-molecular-dynamics-simulations
#14
Hujun Shen, Mingsen Deng, Zhenhua Wu, Jihua Zhang, Yachao Zhang, Chengui Gao, Chao Cen
The effect of cholesterol on membrane dipole potential has been the subject of a great number of experimental and theoretical investigations, but these studies have yielded different findings and interpretations at high cholesterol concentrations. This suggests that the underlying mechanism of the cholesterol effect is not well addressed. Moreover, as far as we know, none of the previously proposed coarse-grained (CG) models (including MARTINI and its improved versions) has been successfully used to probe the effect of cholesterol on membrane dipole potential, owing to either an inaccurate description of water-cholesterol electrostatics or the neglect of the contribution of cholesterol to membrane dipole potential...
May 23, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29790951/internet-use-and-preventive-health-behaviors-among-couples-in-later-life-evidence-from-the-health-and-retirement-study
#15
Sangbo Nam, Sae Hwang Han, Megan Gilligan
Background and Objectives: The aim of this study was to examine the link between internet use and preventive health behaviors. We focused on couples to examine whether there were cross-partner associations between internet use and preventive health behaviors. Research Design and Methods: The data for this study came from the 2010 and 2012 waves of the Health and Retirement Study and the sample consisted of 5,143 pairs of coupled-individuals. Preventive health behaviors included cancer screenings (mammogram and prostate tests), cholesterol tests, and flu shots...
May 22, 2018: Gerontologist
https://www.readbyqxmd.com/read/29790793/increased-arterial-stiffness-similar-findings-in-patients-with-inflammatory-bowel-disease-without-prior-hypertension-or-diabetes-and-in-patients-with-well-controlled-hypertension
#16
Radovan Prijić, Vedran Premužić, Marko Brinar, Željko Krznarić, Bojan Jelaković, Silvija Čuković-Čavka
PURPOSE: Chronic inflammatory diseases are related with earlier onset of atherosclerosis. We hypothesized that inflammatory bowel disease patients with chronic, systemic inflammation have an increased arterial stiffness associated with the disease duration. Also, we wanted to compare arterial stiffness markers between inflammatory bowel disease and well-controlled hypertension patients. MATERIALS AND METHODS: A total of 89 inflammatory bowel disease patients (60 patients with Crohn's disease and 29 patients with ulcerative colitis, age range 20-64 years) without history of arterial hypertension or diabetes were enrolled and age matched with a control group of patients (73 patients, age range 25-69 years, 41 (56...
May 23, 2018: Blood Pressure
https://www.readbyqxmd.com/read/29790688/loganic-acid-and-anthocyanins-from-cornelian-cherry-cornus-mas-l-fruits-modulate-diet-induced-atherosclerosis-and-redox-status-in-rabbits
#17
Tomasz Sozański, Alicja Z Kucharska, Stanisław Dzimira, Jan Magdalan, Dorota Szumny, Agnieszka Matuszewska, Beata Nowak, Narcyz Piórecki, Adam Szeląg, Małgorzata Trocha
BACKGROUND: Cornelian cherry (Cornus mas L.) is a plant growing in southeast Europe, in the past used in folk medicine. There are many previous publications showing the preventive effects of (poly)phenolic compounds, especially anthocyanins, on cardiovascular diseases, but there is a lack of studies comparing the effects of (poly)phenolics and other constituents of fruits. OBJECTIVES: We have attempted to determine if iridoids and anthocyanins from cornelian cherry fruits may affect the formation of atherosclerotic plaques in the aorta as well as lipid peroxidation and oxidative stress in the livers of cholesterol-fed rabbits...
April 25, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29790546/dietary-fibers-prebiotics-and-exopolysaccharides-produced-by-lactic-acid-bacteria-potential-health-benefits-with-special-regard-to-cholesterol-lowering-effects
#18
REVIEW
E Korcz, Z Kerényi, L Varga
The gastrointestinal (GIT) microbiota, which plays a crucial role in human health, is influenced by a number of factors including diet. Consumption of specific dietary ingredients, such as dietary fibers and prebiotics, is an avenue by which the microbiota can be positively modulated. These substances may also reduce serum cholesterol levels through various mechanisms. Interest has increased in methods of reducing blood cholesterol level, because dyslipidemia is recognized as a contributory risk factor for the development of cardiovascular diseases...
May 23, 2018: Food & Function
https://www.readbyqxmd.com/read/29790221/exploring-the-effect-of-a-lifestyle-intervention-on-cancer-risk-43-year-follow-up-of-the-randomized-oslo-diet-and-antismoking-study
#19
E Botteri, T de Lange, S Tonstad, P Berstad
BACKGROUND/OBJECTIVES: The Oslo diet and antismoking study showed that counselling for a healthy lifestyle reduced lifelong coronary mortality in high-risk men. We explored whether the same counselling reduced also cancer risk. METHODS: The study randomly allocated males at high coronary risk to either a 5-year intervention for lifestyle changes (cholesterol-lowering dietary changes, weight loss and stopping smoking) or a control group (1 : 1) in 1972/73. We explored the incidence and mortality of all cancers and cancer forms related to smoking, BMI or diet up to 43 years after randomization...
May 22, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29789988/growth-performance-blood-parameters-carcass-characteristics-and-meat-quality-traits-in-potchefstroom-koekoek-chickens-fed-lippia-javanica-leaf-meal
#20
T B Matshogo, V Mlambo, U Marume, N Sebola
Lippia javanica leaves may have nutraceutical bioactivity and thus could be a viable alternative to antibiotic growth promoters in poultry diets. To test this hypothesis, a feeding trial was carried out to determine the effects of dietary inclusion of Lippia javanica leaf meal (LJ) on growth performance, blood parameters, carcass characteristics and meat quality of indigenous Potchefstroom Koekoek (PK) chickens. The leaf meal was used to dilute a commercial chicken grower diet at a rate of 25 or 50 g/kg diet...
May 22, 2018: Tropical Animal Health and Production
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