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https://www.readbyqxmd.com/read/28917688/a-randomized-trial-of-pocket-echocardiography-integrated-mobile-health-device-assessments-in-modern-structural-heart-disease-clinics
#1
Sanjeev P Bhavnani, Srikanth Sola, David Adams, Ashwin Venkateshvaran, P K Dash, Partho P Sengupta
OBJECTIVES: This study sought to determine whether mobile health (mHealth) device assessments used as clinical decision support tools at the point-of-care can reduce the time to treatment and improve long-term outcomes among patients with rheumatic and structural heart diseases (SHD). BACKGROUND: Newly developed smartphone-connected mHealth devices represent promising methods to diagnose common diseases in resource-limited areas; however, the impact of technology-based care on long-term outcomes has not been rigorously evaluated...
September 9, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28917548/volar-capsular-release-after-distal-radius%C3%A2-fractures
#2
Robin N Kamal, David S Ruch
PURPOSE: Loss of full wrist range of motion is common after treatment of distal radius fractures. Loss of wrist extension limiting functional activities, although uncommon, can occur after volar plating of distal radius fractures. Unlike other joints in which capsular release is a common form of treatment for stiffness, this has been approached with caution in the wrist owing to concerns for carpal instability. We tested the null hypothesis that hardware removal and open volar capsular release would not lead to improved upper extremity-specific patient-reported outcome (Disabilities of the Arm, Shoulder, and Hand [DASH] questionnaire)...
September 14, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28916907/pharmacokinetic-study-of-piracetam-in-focal-cerebral-ischemic-rats
#3
Pankaj Paliwal, Debabrata Dash, Sairam Krishnamurthy
BACKGROUND AND OBJECTIVE: Cerebral ischemia affects hepatic enzymes and brain permeability extensively. Piracetam was investigated up to phase III of clinical trials and there is lack of data on brain penetration in cerebral ischemic condition. Thus, knowledge of the pharmacokinetics and brain penetration of piracetam during ischemic condition would aid to improve pharmacotherapeutics in ischemic stroke. METHODS: Focal cerebral ischemia was induced by middle cerebral artery occlusion for 2 h in male Wistar rats followed by reperfusion...
September 15, 2017: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/28915461/forecasting-wheat-and-barley-crop-production-in-arid-and-semi-arid-regions-using-remotely-sensed-primary-productivity-and-crop-phenology-a-case-study-in-iraq
#4
Sarchil Hama Qader, Jadunandan Dash, Peter M Atkinson
Crop production and yield estimation using remotely sensed data have been studied widely, but such information is generally scarce in arid and semi-arid regions. In these regions, inter-annual variation in climatic factors (such as rainfall) combined with anthropogenic factors (such as civil war) pose major risks to food security. Thus, an operational crop production estimation and forecasting system is required to help decision-makers to make early estimates of potential food availability. Data from NASA's MODIS with official crop statistics were combined to develop an empirical regression-based model to forecast winter wheat and barley production in Iraq...
September 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28914940/asymmetric-dual-loop-feedback-to-suppress-spurious-tones-and-reduce-timing-jitter-in-self-mode-locked-quantum-dash-lasers-emitting-at-1-55%C3%A2-%C3%A2-%C3%AE-m
#5
Haroon Asghar, John G McInerney
We demonstrate an asymmetric dual-loop feedback method to suppress external cavity side-modes induced in self-mode-locked quantum-dash lasers with conventional single- and dual-loop feedback. In this Letter, we report optimal suppression of spurious tones by optimizing the delay in the second loop. We observed that asymmetric dual-loop feedback, with large (∼8×) disparity in loop lengths, gives significant suppression in external-cavity side-modes and produces flat radio frequency (RF) spectra close to the main peak with a low timing jitter, compared to single-loop feedback...
September 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28914307/revealing-the-distinct-thermal-transition-behavior-between-pega-based-linear-polymers-and-their-disulfide-cross-linked-nanogels
#6
Wenhui Sun, Zesheng An, Peiyi Wu
The distinct thermal transition behavior of thermoresponsive block polymers based on poly(ethylene glycol)methyl ether acrylate (PEGA) and their corresponding disulfide-cross-linked nanogels was studied by using FTIR measurements in combination with two-dimensional correlation spectroscopy (2Dcos). Spectral analysis clearly reveals that the sharp thermal transition of the precursor polymer is accompanied by a forced hydration process induced by the formation of hydrogen bonds between the entrapped water molecules and the C[double bond, length as m-dash]O groups, while the nanogel with a relatively continuous thermal transition is related to the existence of various dehydrating states of the C[double bond, length as m-dash]O groups...
September 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28913569/antegrade-intramedullary-kirschner-wire-fixation-of-displaced-metacarpal-shaft-fractures
#7
E M van Bussel, R M Houwert, T J M Kootstra, M van Heijl, D Van der Velde, Ph Wittich, J Keizer
PURPOSE: The objective of this study was to analyze complications and patient-related functional outcome after antegrade intramedullary Kirschner-wire fixation of metacarpal shaft fractures. METHODS: All consecutive patients treated from January 2010 until December 2015 were retrospectively analyzed using patient logs and radiographic images. Indications for operative fixation were angulation > 40°, shortening > 2 mm, or rotational deficit. Complications were registered from the patient logs...
September 14, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28913382/psychometric-properties-of-the-persian-version-of-the-patient-rated-wris-t-evaluation
#8
Golnaz Ghayyem Hassankhani, Ali Moradi, Ehsan Vahedi, Sayyed Hadi Sayyed Hoseinian, Zohreh Jahani, Maedeh Rahmani, Mohammad H Ebrahimzadeh
BACKGROUND: The patient-rated wrist evaluation (PRWE) score is one of the most common clinical instruments used as an outcome measurement tool for distal radius fractures and other upper extremity conditions. The purpose of this study was to translate the PRWE into its Persian version and to evaluate its validity and reliability in patients with upper extremity conditions. METHODS: One hundred and fourthly one adult patients with upper extremity conditions participated in this ethical board approved study from August 2015 to May 2016...
July 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/28912564/transcriptome-analysis-of-developing-lens-reveals-abundance-of-novel-transcripts-and-extensive-splicing-alterations
#9
Rajneesh Srivastava, Gungor Budak, Soma Dash, Salil A Lachke, Sarath Chandra Janga
Lens development involves a complex and highly orchestrated regulatory program. Here, we investigate the transcriptomic alterations and splicing events during mouse lens formation using RNA-seq data from multiple developmental stages, and construct a molecular portrait of known and novel transcripts. We show that the extent of novelty of expressed transcripts decreases significantly in post-natal lens compared to embryonic stages. Characterization of novel transcripts into partially novel transcripts (PNTs) and completely novel transcripts (CNTs) (novelty score ≥ 70%) revealed that the PNTs are both highly conserved across vertebrates and highly expressed across multiple stages...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28910148/bulk-scale-formulation-of-therapeutic-doses-of-clinical-grade-ready-to-use-177-lu-dota-tate-the-intricate-radiochemistry-aspects
#10
Anupam Mathur, Vrinda Prashant, Navin Sakhare, Sudipta Chakraborty, K V Vimalnath, Repaka Krishna Mohan, Chanda Arjun, Barkha Karkhanis, Ravi Seshan, Sandip Basu, Aruna Korde, Sharmila Banerjee, Ashutosh Dash, Satbir Singh Sachdev
INTRODUCTION: (177)Lu-DOTA-TATE is a clinically useful and promising therapeutic radiopharmaceutical for peptide receptor radionuclide therapy of neuroendocrine tumors (NETs) overexpressing somatostatin receptors. Currently, the radiopharmaceutical is prepared in-house at nuclear medicine centers, thereby restricting its use to limited centers only. In this article, the authors describe systematic studies toward bulk scale formulation of "ready-to-use" (177)Lu-DOTA-TATE using medium specific activity (177)Lu (740-1110 GBq/mg) at a centralized radiopharmacy facility...
September 2017: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28906587/vascularized-thumb-metacarpal-periosteal-pedicled-flap-for-scaphoid-nonunion-an-anatomical-study-and-pediatric-case-report
#11
Sergi Barrera-Ochoa, Gerardo Mendez-Sanchez, Alfonso Rodriguez-Baeza, Jorge Knörr, Jayme Augusto Bertelli, Francisco Soldado
PURPOSE: Through an anatomical review, the primary aim of this study was to delineate the dorsal thumb metacarpal (TM) periosteal branches of the radial artery (RA). In addition, we report here the clinical utility of a vascularized TM periosteal pedicled flap (VTMPF), supplied by the first dorsal metacarpal artery (FDMA), in a complex case of scaphoid nonunion. METHODS: Ten latex-colored upper limbs from fresh human cadavers were used. Branches of the RA were dissected under 3x loupe magnification, noting the periosteal branches arising from the FDMA...
September 14, 2017: Microsurgery
https://www.readbyqxmd.com/read/28904638/functional-outcomes-following-non-operative-versus-operative-treatment-of-clavicle-fractures-in-adolescents
#12
M M Herzog, R C Whitesell, L M Mac, M L Jackson, B A Culotta, J R Axelrod, M T Busch, S C Willimon
PURPOSE: Superiority of non-operative versus operative treatment of clavicle shaft fractures remains unclear. We aimed to assess shoulder function in adolescents following shortened clavicle fracture and compare operative versus non-operative treatment. METHODS: Patients aged 12 to 18 years at the time of fracture and minimum 1.5 years post injury were identified for this institutional review board (IRB)-approved study. For this retrospective cohort study, patients were frequency-matched for age, gender, shortening of the clavicle fracture and activity level...
August 1, 2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/28903000/structural-revision-of-baulamycin-a-and-structure-activity-relationships-of-baulamycin-a-derivatives
#13
Sandip Sengupta, Munhyung Bae, Dong-Chan Oh, Uttam Dash, Hak Joong Kim, Woon Young Song, Injae Shin, Taebo Sim
Total synthesis of the proposed structure of baulamycin A was performed. The spectral properties of the synthetic compound differ from those reported for the natural product. On the basis of comprehensive NMR study, we proposed two other possible structures for natural baulamycin A. Total syntheses of these two substances were performed, which enabled assignment of the correct structure of baulamycin A. Key features of the convergent and fully stereo-controlled route include Evans Aldol and Brown allylation reactions to construct the left fragment, a prolinol amide-derived alkylation/desymmetrization to install the methyl substituted centers in the right fragment, and finally a Carreira alkynylation to join both fragments...
September 13, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28902808/-anticoagulant-therapy-of-venous-thromboembolic-complications-balancing-between-risks
#14
K V Lobastov, S V Sapelkin
This article is a review of the literature, related to the problem of recurrence of venous thromboembolic complications and the possibilities of their secondary prevention. The problems of determining the rational duration of anticoagulant therapy on the basis of an individual assessment of its benefit and risk are considered. The information on modern prognostic models allowing quantitative assessment of the probability of hemorrhagic and thrombotic events occurrence is presented (Vienna prediction model, DASH, HAS-BLED, stratification according to ACCP 2016)...
2017: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/28901795/clinical-and-radiographic-outcomes-of-unipolar-and-bipolar-radial-head-prosthesis-in-patients-with-radial-head-fracture-a-systemic-review-and-meta-analysis
#15
Hongwei Chen, Ziyang Wang, Yongjun Shang
PURPOSE: To compare clinical outcomes of unipolar and bipolar radial head prosthesis in the treatment of patients with radial head fracture. MATERIALS AND METHODS: Medline, Cochrane, EMBASE, Google Scholar databases were searched until April 18, 2016 using the following search terms: radial head fracture, elbow fracture, radial head arthroplasty, implants, prosthesis, unipolar, bipolar, cemented, and press-fit. Randomized controlled trials, retrospective, and cohort studies were included...
September 13, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28901528/beyond-symptomatic-effects-donepezil-s-potential-for-neuroprotection-and-disease-modification-in-alzheimer-s-disease
#16
REVIEW
Seung Hyun Kim, Nagaendran Kandiah, Jung-Lung Hsu, Chuthamanee Suthisisang, Chesda Udommongkol, Amitabh Dash
Alzheimer's disease (AD) is associated with neurodegenerative changes resulting clinically in progressive cognitive and functional deficits. The only therapies are the cholinesterase inhibitors (ChEIs) donepezil, galantamine, and rivastigmine and the N-methyl-D-aspartate-receptor antagonist memantine. Donepezil acts primarily on the cholinergic system as symptomatic treatment, but it also has potential for disease modification and may reduce the rate of progression of AD. This review explores the potential for a disease modifying effect of donepezil...
September 13, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28901363/the-mechanism-for-catalytic-hydrosilylation-by-bis-imino-pyridine-iron-olefin-complexes-supported-by-broken-symmetry-density-functional-theory
#17
Yan Choi Lam, Robert J Nielsen, William A Goddard, Aswini K Dash
Density functional theory (DFT, B3LYP-D3 with implicit solvation in toluene) was used to investigate the mechanisms of olefin hydrosilylation catalyzed by PDI(Fe) (bis(imino)pyridine iron) complexes, where PDI = 2,6-(ArN[double bond, length as m-dash]CMe)2(C5H3N) with Ar = 2,6-R2-C6H3. We find that the rate-determining step for hydrosilylation is hydride migration from Et3SiH onto the Fe-bound olefin to form (PDI)Fe(alkyl)(SiEt3). This differs from the mechanism for the Pt Karstedt catalyst in that there is no prior Si-H oxidative addition onto the Fe center...
September 13, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28900671/-wrist-arthrodesis-with-a%C3%A2-fixed-angle-low-profile-fusion-plate-without-carpometacarpal-joint-fixation
#18
REVIEW
S Köhler, K Koch, A Arsalan-Werner, I M Mehling, J Seegmüller, H Krimmer, Michael Sauerbier
OBJECTIVE: Total wrist arthrodesis to improve functional use of the hand by reducing pain and increasing grip strength. INDICATIONS: Painful destruction of the radio- and midcarpal joints. CONTRAINDICATIONS: Analgesia and satisfactory hand function after motion-preserving surgical or conservative treatment. Chronic joint infection. SURGICAL TECHNIQUE: Posterior approach to the wrist. Removal of articular surfaces destroyed all the way down to cancellous bone...
September 12, 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/28898104/rotator-cuff-calcific-tendinitis-ultrasound-guided-needling-and-lavage-versus-subacromial-corticosteroids-five-year-outcomes-of-a-randomized-controlled-trial
#19
Pieter Bas de Witte, Arjen Kolk, Ferdinand Overes, Rob G H H Nelissen, Monique Reijnierse
BACKGROUND: Barbotage (needling and lavage) is often applied in the treatment of calcific tendinitis of the rotator cuff (RCCT). In a previously published randomized controlled trial, we reported superior clinical and radiological 1-year outcomes for barbotage combined with a corticosteroid injection in the subacromial bursa (SAIC) compared with an isolated SAIC. There are no trials with a midterm or long-term follow-up of barbotage available. PURPOSE: To compare the 5-year results of 2 regularly applied treatments of RCCT: ultrasound (US)-guided barbotage combined with a SAIC (group 1) versus an isolated US-guided SAIC (group 2)...
September 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28894867/do-alkyl-groups-on-aromatic-or-aliphatic-structure-directing-agents-affect-water-stabilities-and-properties-of-hybrid-iodoargentates
#20
Guang-Ning Liu, Xu Zhang, Hong-Mei Wang, Hong Xu, Zi-Han Wang, Xiang-Long Meng, Ya-Nan Dong, Ruo-Yu Zhao, Cuncheng Li
Two types of in situ formed structure directing agents (SDAs) including aromatic triphenylphosphine (PPh3)- and aliphatic piperazine (H2pp)-derivative cations were used to synthesize five new hybrid iodoargentates, namely (EtPPh3)Ag3I4 (1, Et = ethyl), (n-PrPPh3)Ag3I4 (2, n-Pr = n-propyl), (i-PrPPh3)Ag5I6 (3, i-Pr = isopropyl), (Me4pp)0.5AgI2 (4, Me = methyl), and (H3app)2(Ag2I6)·2I·2H2O (5, app = N-aminoethylpiperazine). A comparative study of the two types of SDAs on the structures, stabilities and properties of hybrid iodoargentates was performed in detail...
September 12, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
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