keyword
https://read.qxmd.com/read/38385385/efficacy-of-mtor-inhibitors-and-intravenous-immunoglobulin-for-treatment-of-polyoma-bk-nephropathy-in-kidney-transplant-recipients-a-biopsy-proven-study
#1
JOURNAL ARTICLE
Murat Karatas, Erhan Tatar, Gokalp Okut, Ali Murat Yildirim, Emre Kocabas, Funda Tasli Alkan, Cenk Simsek, Sait Murat Dogan, Adam Uslu
OBJECTIVES: We investigated the efficacy of a predetermined protocol that consisted of immunosuppressive drug reduction/withdrawal and intravenous immunoglobulin administration for the treatment of polyoma BK virus nephropathy. MATERIALS AND METHODS: Patients with biopsy-proven polyoma BK virus nephropathy received a treatment regimen based on discontinuation of both calcineurin inhibitors and antiproliferative agents and switching to mTOR inhibitors accompanied by intravenous immunoglobulin administration...
January 2024: Experimental and Clinical Transplantation
https://read.qxmd.com/read/38337826/generation-of-jc-polyoma-pseudovirus-for-high-throughput-measurement-of-neutralizing-antibodies
#2
JOURNAL ARTICLE
Mami Matsuda, Tian-Cheng Li, Akira Nakanishi, Kazuo Nakamichi, Makoto Saito, Tadaki Suzuki, Tomokazu Matsuura, Masamichi Muramatsu, Tetsuro Suzuki, Yoshiharu Miura, Ryosuke Suzuki
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system (CNS) caused by reactivation of dormant JC polyomavirus (JCPyV). PML was mainly observed in immunocompromised individuals, such as HIV-positive patients, autoimmune disease patients, and cancer patients. Given that the presence of anti-JCPyV antibodies in serum is a risk indicator for PML development, it is essential to monitor anti-JCPyV antibody levels. In the present study, we established reporter-based single-infection neutralization assays for JCPyV and the genetically similar BK polyoma virus (BKPyV)...
January 31, 2024: Diagnostics
https://read.qxmd.com/read/38332424/incidence-of-postoperative-cytomegalovirus-and-bk-polyoma-virus-infections-and-graft-loss-in-abo-incompatible-renal-transplant-recipients-a-multicenter-retrospective-study
#3
JOURNAL ARTICLE
Hirotake Kodama, Shingo Hatakeyama, Tomohiko Matsuura, Mitsuru Saito, Hayato Nishida, Tomoko Hamaya, Shinya Maita, Reiichi Murakami, Hirofumi Tomita, Hisao Saitoh, Norihiko Tsuchiya, Tomonori Habuchi, Wataru Obara, Chikara Ohyama
OBJECTIVES: The current study aimed to examine the incidence of perioperative infections and graft viability in ABO-compatible and ABO-incompatible renal transplant recipients. METHODS: We included 643 living donor renal transplant recipients registered in the Michinoku Renal Transplant Network from 1998 to 2021. Patients were divided into the ABO-compatible and ABO-incompatible kidney transplantation groups. We compared the characteristics of the two groups and evaluated the incidence of postoperative viral infections (cytomegalovirus and BK virus), graft loss-free survival, and overall survival between the two groups...
February 9, 2024: International Urology and Nephrology
https://read.qxmd.com/read/38213487/protocolized-polyoma-bk-viral-load-monitoring-and-high-dose-immunoglobulin-treatment-in-children-after-kidney-transplant
#4
JOURNAL ARTICLE
Shirley Pollack, Moran Plonsky-Toder, Rami Tibi, Renata Yakubov, Irina Libinson-Zebegret, Daniella Magen
BACKGROUND: BKPyV virus nephropathy (BKPyVAN) is diagnosed in 5%-16% of pediatric renal transplant recipients (PRTR) and preceded by BKPyV-viruria and DNAemia. Despite the risk of irreversible transplant damage associated with BKPyVAN, evidence-based consensus guidelines for BKPyVAN prevention are still lacking. In this retrospective study, we examined the safety and efficacy of high-dose intravenous immunoglobulin (HD-IVIG) therapy for prevention of BKPyVAN in PRTR with significant BKPyV-viruria/DNAemia...
January 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38139342/acute-kidney-injury-and-bk-polyomavirus-in-urine-sediment-cells
#5
JOURNAL ARTICLE
Sahra Pajenda, Daniela Anna Gerges, Raimundo Freire, Ludwig Wagner, Zsofia Hevesi, Monika Aiad, Michael Eder, Alice Schmidt, Wolfgang Winnicki, Farsad Alexander Eskandary
Polyomaviruses are widespread, with BK viruses being most common in humans who require immunosuppression due to allotransplantation. Infection with BK polyomavirus (BKV) may manifest as BK virus-associated nephropathy and hemorrhagic cystitis. Established diagnostic methods include the detection of polyomavirus in urine and blood by PCR and in tissue biopsies via immunohistochemistry. In this study, 79 patients with pathological renal retention parameters and acute kidney injury (AKI) were screened for BK polyomavirus replication by RNA extraction, reverse transcription, and virus-specific qPCR in urine sediment cells...
December 15, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38133339/concomitant-polyoma-bk-virus-and-west-nile-virus-in-renal-allografts
#6
Riddhish T Sheth, Dalia Y Ibrahim, Amira F Gohara, Obi Ekwenna, Michael A Rees, Deepak Malhotra, William T Gunning
Surveillance of the renal allograft recipient is essential when monitoring renal function to detect the early onset of rejection and alter therapeutic treatments to treat acute rejection or other causes and improve long-term graft function. If renal function begins to deteriorate, a renal biopsy is often indicated to assess the Banff grade of potential rejection or other causes, especially in the setting of polyoma BK viral load elevation. Although BK infection in the allograft is asymptomatic, reactivation of the virus is known to be associated with the acceleration of pathologic change and a poor outcome in the allograft...
December 15, 2023: Pathogens
https://read.qxmd.com/read/37650442/high-grade-urothelial-carcinoma-in-kidney-transplant-patients-with-a-history-of-bk-viremia-just-a-coincidence
#7
JOURNAL ARTICLE
Emma Cannon, Chara Ntala, Nicola Joss, Maeve Rahilly, Wendy Metcalfe, Marie O'Donnell, Paul J Phelan
INTRODUCTION: Kidney transplant recipients (KTR) have a three-to-four-fold increased risk of developing urothelial carcinoma (UC) compared to the general population. BK polyoma virus (BKV) infection is known to affect approximately 15% of KTR. In vitro models support a potential pathogenic role for BKV in the development of UC. We describe a series of UC in kidney transplant recipients. METHODS: Electronic patient records were searched to identify KTR with UC who had undergone kidney only or simultaneous kidney and pancreas transplantation in a single UK center between 2009 and 2015...
August 31, 2023: Clinical Transplantation
https://read.qxmd.com/read/37641175/a-multicenter-retrospective-cohort-study-on-management-protocols-and-clinical-outcomes-after-abo-incompatible-kidney-transplantation-in-india
#8
JOURNAL ARTICLE
Vivek B Kute, Vivek Pathak, Deepak S Ray, Anil K Bhalla, Suraj M Godara, Sajith Narayanan, Umapati Hegde, Pratik Das, Pranaw Kumar Jha, Vijay Kher, Sonal Dalal, Madan M Bahadur, Sishir Gang, Vijay Kumar Sinha, Himanshu V Patel, Rushi Deshpande, Manish Mali, Ashish Sharma, Sushree Sashmita Das, Sharmila Thukral, Ashay Shingare, Anil Kumar Bt, Benil Hafeeq, Feroz Aziz, Ismail N Aboobacker, Jyotish Chalil Gopinathan, Rutul M Dave, Dinesh Bansal, Urmila Anandh, Sarbpreet Singh, Jai Kriplani, Suhas Bavikar, Vishwanath Siddini, Satish Balan, Manish Singla, Munish Chauhan, Vidyanand Tripathi, Devang Patwari, Abi M Abraham, Sanshriti Chauhan, Hari Shankar Meshram
BACKGROUND: There is no robust evidence-based data for ABO-incompatible kidney transplantation (ABOiKT) from emerging countries. METHODS: Data from 1759 living donor ABOiKT and 33 157 ABO-compatible kidney transplantations (ABOcKT) performed in India between March 5, 2011, and July 2, 2022, were included in this retrospective, multicenter (n = 25) study. The primary outcomes included management protocols, mortality, graft loss, and biopsy-proven acute rejection (BPAR)...
August 29, 2023: Transplantation
https://read.qxmd.com/read/37511901/lessons-from-polyomavirus-immunofluorescence-staining-of-urinary-decoy-cells
#9
JOURNAL ARTICLE
Sahra Pajenda, Zsofia Hevesi, Michael Eder, Daniela Gerges, Monika Aiad, Oliver Koldyka, Wolfgang Winnicki, Ludwig Wagner, Farsad Eskandary, Alice Schmidt
Decoy cells that can be detected in the urine sediment of immunosuppressed patients are often caused by the uncontrolled replication of polyomaviruses, such as BK-Virus (BKV) and John Cunningham (JC)-Virus (JCV), within the upper urinary tract. Due to the wide availability of highly sensitive BKV and JCV PCR, the diagnostic utility of screening for decoy cells in urine as an indicator of polyomavirus-associated nephropathy (PyVAN) has been questioned by some institutions. We hypothesize that specific staining of different infection time-dependent BKV-specific antigens in urine sediment could allow cell-specific mapping of antigen expression during decoy cell development...
July 7, 2023: Life
https://read.qxmd.com/read/37093358/acute-kidney-injury-in-an-allogeneic-hematopoietic-cell-transplant-recipient-answers
#10
JOURNAL ARTICLE
Zeynep Kemer Aktaş, Gülşah Kaya Aksoy, Havva Serap Toru, Mustafa Koyun, Elif Çomak, Elif Güler, Mehmet Emin Kuş, Sema Akman
No abstract text is available yet for this article.
April 24, 2023: Pediatric Nephrology
https://read.qxmd.com/read/36856222/-analysis-of-causes-of-graft-loss-in-135-kidney-transplant-recipients
#11
JOURNAL ARTICLE
Y Liu, H Bai, Y Qian, C Li, L Xiao, R Zhu
OBJECTIVE: To investigate the causes of graft loss in kidney transplant recipients. METHODS: We retrospectively analyzed the clinical data of 135 recipients with graft loss after renal transplantation in the Eighth Medical Center of Chinese PLA General Hospital from January 1, 2002 to January 1, 2022. RESULTS: A total of 135 kidney transplant recipients experienced graft failure. The causes of graft loss included graft rejection (70 cases, 51...
January 20, 2023: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://read.qxmd.com/read/36804135/bk-dnaemia-and-native-kidney-polyomavirus-nephropathy-following-lung-transplantation
#12
JOURNAL ARTICLE
Geoffrey K Dube, Ibrahim Batal, Lori Shah, Hilary Robbins, Selim M Arcasoy, Syed Ali Husain
BK virus DNAemia (BKPyV) and nephropathy are common after kidney transplant; however, there are limited data on BK infections in nonrenal solid organ transplant recipients. We examined the frequency, clinical and pathologic features, and kidney and lung outcomes of BKPyV and BK virus native kidney nephropathy (BKVN) in lung transplant recipients at our center. Among 878 recipients transplanted from 2003 to 2019, 56 (6%) developed BKPyV at a median of 30.1 months after transplant (range, 0.6-213) and 11 (1.3%) developed BKVN at a median of 46 months after transplant (range, 9-213)...
February 2023: American Journal of Transplantation
https://read.qxmd.com/read/35980197/impact-of-antimetabolite-discontinuation-following-cytomegalovirus-or-bk-polyoma-virus-infection-in-kidney-transplant-recipients
#13
JOURNAL ARTICLE
Casey A Dubrawka, Kristin J Progar, Spenser E January, Jennifer C Hagopian, Nicole M Nesselhauf, Andrew F Malone
BACKGROUND: Cytomegalovirus (CMV) and BK polyoma virus (BKV) infection following kidney transplantation have been associated with allograft dysfunction and allograft loss. Reduction in immunosuppression is a mainstay of management yet has been associated with increased risk of rejection. According to international consensus guidelines, one approach to management of these viral infections is to discontinue the antimetabolite. Little is known surrounding long-term outcomes in these patients, and it remains unclear if consideration should be given to resuming the antimetabolite as variable re-escalation strategies have been reported...
December 2022: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/35876981/investigating-causes-and-risk-factors-of-pre-chemotherapy-viremia-in-acute-lymphoblastic-leukemia-pediatric-patients
#14
JOURNAL ARTICLE
Nivin Abdel-Azim, Lamiaa Fadel Alkilany, Zeinab Korany Hassan, Noha Gaber
BACKGROUND: Leukemia patients are immune-compromised even before starting chemotherapy because the malignant cells invade the bone marrow and destroy WBC precursors. Leukemic patients are more susceptible to infection by a wide range of microorganisms. Viral infections and reactivations are common and may result in severe complications. The aim of this study is to investigate different causes of viremia in ALL pediatric patients as well as the clinical and the laboratory characteristics associated with viral infections...
July 25, 2022: Infection
https://read.qxmd.com/read/35856116/anterior-pelvic-exenteration-and-synchronous-bilateral-nephroureterectomy-for-bk-polyoma-virus-induced-urothelial-carcinoma-of-the-bladder-a-case-report
#15
JOURNAL ARTICLE
Oliver Oey, Pravin Viswambaram, Andrew Moe, Nicole Swarbick, Dickon Hayne
BK polyoma virus (BKV) is a known risk factor for the development of urothelial carcinoma. There is currently limited data on the management of BKV-induced urothelial carcinoma (BUC) of the bladder, with available data limited to case reports. It remains debatable whether radical cystectomy (RC) with removal of the native urinary tract or RC alone is the most optimal management for BUC of the bladder. BKV-induced urothelial carcinoma is rare, and its management is challenging in immunocompromised patients such as that of post-transplant patients...
June 30, 2022: Folia Medica
https://read.qxmd.com/read/35429074/is-there-a-case-for-early-treatment-with-ivig-for-bk-transplant-nephropathy
#16
EDITORIAL
Arjun Amrit Kirpalani, Guido Filler, Chia Wei Teoh
No abstract text is available yet for this article.
June 2022: Pediatric Transplantation
https://read.qxmd.com/read/35371460/native-bk-virus-nephropathy-in-lung-transplant-a-case-report-and-literature-review
#17
JOURNAL ARTICLE
Waseem Albasha, Golnaz Vahdani, Ankita Ashoka, Erika Bracamonte, Amy A Yau
Classically described in renal allografts, BK virus nephropathy is increasingly recognized in native kidneys of other non-renal solid organ transplants. We discuss a 68-year-old woman with a history of bilateral lung transplant referred for worsening renal function, confirmed to have BK virus nephropathy by biopsy with a serum BK virus polymerase chain reaction of over 59 million copies/mL. She was managed with a reduction in immunosuppression and intravenous cidofovir with no improvement in her clinical parameters...
April 2022: Clinical Kidney Journal
https://read.qxmd.com/read/35368114/ifnl4-rs368234815-polymorphism-does-not-predict-risk-of-bk-virus-associated-nephropathy-after-living-donor-kidney-transplant-a-case-control-study
#18
JOURNAL ARTICLE
Ursula Tanriver, Florian Emmerich, Jonas Florian Hummel, Bernd Jänigen, Marcus Panning, Frederic Arnold, Yakup Tanriver
BACKGROUND: BK polyoma virus (BKPyV) associated nephropathy (BKPyVAN) is a major cause of kidney graft loss in renal transplant patients. Interferons (IFNs) are an important innate immune response against viral infections and genetic polymorphisms of the IFN-pathways can affect susceptibility and mortality during viral infection. Here, we investigated whether the dinucleotide polymorphism rs368234815 (ΔG/TT) in the IFNL4 gene contributed to BKPyV reactivation or BKPyVAN after living-donor kidney transplantation...
July 2022: Clinical Transplantation
https://read.qxmd.com/read/34817112/ebv-cmv-and-bk-viral-infections-in-pediatric-kidney-transplantation-frequency-risk-factors-treatment-and-outcomes
#19
JOURNAL ARTICLE
Shelly Levi, Miriam Davidovits, Hadas Alfandari, Amit Dagan, Yael Borovitz, Efraim Bilavsky, Daniel Landau, Orly Haskin
BACKGROUND: Improved short- and long-term outcomes of kidney transplantation have been achieved over the past decades due to improved immunosuppression. This may have increased the risk for infections and, particularly, for the viral infections: cytomegalovirus (CMV), Epstein-Barr virus (EBV), and polyoma BK virus (BKV). METHODS: A retrospective review of viremic CMV, EBV, and BKV infections in pediatric renal transplant recipients treated and followed by a national referral center over a 10-year period...
May 2022: Pediatric Transplantation
https://read.qxmd.com/read/34785398/off-the-shelf-third-party-virus-specific-t-cell-therapy-to-treat-jc-polyomavirus-infection-in-hematopoietic-stem-cell-transplantation-recipients
#20
JOURNAL ARTICLE
Jeremy D Rubinstein, Sonata Jodele, Daria Heyenbruch, Jamie Wilhelm, Shawn Thomas, Carolyn Lutzko, Xiang Zhu, Thomas Leemhuis, Jose A Cancelas, Michael Keller, Catherine M Bollard, Patrick J Hanley, Zeinab El Boghdadly, Alice Mims, Stella M Davies, Michael S Grimley, Adam S Nelson
Progressive multifocal leukoencephalopathy (PML) is a progressive and generally fatal demyelinating neurologic disease that occurs in profoundly immunocompromised patients due to infection with the human polyomavirus JC virus (JCPyV). Treatment options are limited and are largely focused on restoring T cell immunity, and outcomes are historically poor. Control of JCPyV in the setting of an immunocompromised patient by adoptive transfer of third-party virus specific T cells (VSTs) has been described in a small number of cases...
February 2022: Transplantation and cellular therapy
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