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https://www.readbyqxmd.com/read/29786043/risk-factors-for-recurrence-of-ovarian-endometriosis-in-chinese-patients-aged-45-and-over
#1
Zheng-Xing He, Ting-Ting Sun, Shu Wang, Hong-Hui Shi, Qing-Bo Fan, Lan Zhu, Jin-Hua Leng, Da-Wei Sun, Jian Sun, Jing-He Lang
Background: When considering the issue of recurrence, perimenopausal women may have more dilemma during management comparing with young women, for example, whether to retain the uterus and ovary during surgery, whether it is necessary to add adjuvant medicine treatment after operation, and there is no evidence for reference about using of gonadotropin-releasing hormone agonist. This study aimed to study the risk factors for the recurrence of ovarian endometriosis (EM) in patients aged 45 and over...
June 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29785388/genital-tuberculosis-in-postmenopausal-women-with-variable-clinical-presentations-a-report-of-3-cases
#2
Ashima Arora, Shameema Anvar Sadath
Genital tuberculosis is usually diagnosed in young women being assessed for infertility. After menopause it usually presents with symptoms resembling endometrial malignancy, such as postmenopausal bleeding, persistent vaginal discharge and pyometra. The diagnosis is made by detection of acid-fast bacilli on microscopy or bacteriological culture and/or presence of epithelioid granuloma on biopsy. Anti-tubercular therapy involves the use of rifampicin, isoniazid, pyrazinamide and ethambutol. Surgery is indicated if a pelvic mass and recurrence of pain or bleeding persist after 9 months of treatment...
April 2018: Case Reports in Women's Health
https://www.readbyqxmd.com/read/29784930/comparative-mrna-and-mirna-expression-in-european-mouflon-ovis-musimon-and-sheep-ovis-aries-provides-novel-insights-into-the-genetic-mechanisms-for-female-reproductive-success
#3
Ji Yang, Xin Li, Yin-Hong Cao, Kisun Pokharel, Xiao-Ju Hu, Ze-Hui Chen, Song-Song Xu, Jaana Peippo, Mervi Honkatukia, Juha Kantanen, Meng-Hua Li
Prolific breeds of domestic sheep (Ovis aries) are important genetic resources due to their reproductive performance, which is characterized by multiple lambs per birth and out-of-season breeding. However, the lack of a comprehensive understanding of the genetic mechanisms underlying the important reproductive traits, particularly from the evolutionary genomics perspective, has impeded the efficient advancement of sheep breeding. Here, for the first time, by performing RNA-sequencing we built a de novo transcriptome assembly of ovarian and endometrial tissues in European mouflon (Ovis musimon) and performed an mRNA-miRNA integrated expression profiling analysis of the wild species and a highly prolific domestic sheep breed, the Finnsheep...
May 21, 2018: Heredity
https://www.readbyqxmd.com/read/29784731/transformed-follicular-lymphoma-tfl-predicts-outcome-in-advanced-endometrial-cancer
#4
Senn Wakahashi, Fumi Kawakami, Kanako Wakahashi, Kentaro Minagawa, Keitaro Matsuo, Yoshio Katayama, Hideto Yamada, Toshimitsu Matsui, Tamotsu Sudo
BACKGROUND: Transformed follicular lymphoma (TFL, ZC3H12D) was identified, as a candidate tumor suppressor gene that contributes to cell-cycle arrest through regulation of Rb phosphorylation, but the clinical impact of TFL is unknown. The goal of this study was to evaluate the prognostic significance of TFL expression in advanced endometrial cancer. METHODS: Tissue samples were obtained from 103 patients with FIGO stage III-IV endometrial cancer. Associations between TFL expression and outcomes were evaluated using the Kaplan-Meier method and multivariate Cox proportional-hazards regression models...
May 21, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29784140/telephone-follow-up-after-treatment-for-endometrial-cancer-a-qualitative-study-of-patients-and-clinical-nurse-specialists-experiences-in-the-endcat-trial
#5
S Williamson, K Beaver, A Gardner, P Martin-Hirsch
PURPOSE: Endometrial cancer is the sixth most common female cancer worldwide. There is little evidence that routine hospital surveillance increases survival or decreases morbidity following treatment. Gynaecology Oncology clinical nurse specialists (CNSs) are ideally placed to provide the care, information and support to enable women with a gynaecological cancer to self-manage and live well. A multi-centre randomised controlled trial (RCT) compared hospital follow-up (HFU) with telephone follow-up (TFU) by CNSs...
June 2018: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/29784012/treatment-of-experimental-colitis-by-endometrial-regenerative-cells-through-regulation-of-b-lymphocytes-in-mice
#6
Xiaoxi Xu, Yong Wang, Baoren Zhang, Xu Lan, Shanzheng Lu, Peng Sun, Xiang Li, Ganggang Shi, Yiming Zhao, Hongqiu Han, Caigan Du, Hao Wang
BACKGROUND: Endometrial regenerative cells (ERCs), a novel type of mesenchymal-like stem cell derived from menstrual blood, have been recently evaluated as an attractive candidate source in ulcerative colitis (UC); however, the mechanism is not fully understood. The present study was designed to investigate the effects of ERCs, especially on B-cell responses in UC. METHODS: In this study, colitis was induced by administering 3% dextran sodium sulfate (DSS) via free drinking water for 7 days to BALB/c mice...
May 22, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29783999/identification-of-micro-rna-expression-profile-related-to-recurrence-in-women-with-esmo-low-risk-endometrial-cancer
#7
Tiphaine de Foucher, Maria Sbeih, Jenifer Uzan, Sofiane Bendifallah, Marine Lefevre, Nathalie Chabbert-Buffet, Selim Aractingi, Catherine Uzan, Issam Abd Alsalam, Rana Mitri, Romain H Fontaine, Emile Daraï, Bassam Haddad, Céline Méhats, Marcos Ballester, Geoffroy Canlorbe, Cyril Touboul
BACKGROUND: Actual European pathological classification of early-stage endometrial cancer (EC) may show insufficient accuracy to precisely stratify recurrence risk, leading to potential over or under treatment. Micro-RNAs are post-transcriptional regulators involved in carcinogenic mechanisms, with some micro-RNA patterns of expression associated with EC characteristics and prognosis. We previously demonstrated that downregulation of micro-RNA-184 was associated with lymph node involvement in low-risk EC (LREC)...
May 21, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29783979/lynch-syndrome-associated-endometrial-carcinoma-with-mlh1-germline-mutation-and-mlh1-promoter-hypermethylation-a-case-report-and-literature-review
#8
Takanori Yokoyama, Kazuhiro Takehara, Nao Sugimoto, Keika Kaneko, Etsuko Fujimoto, Mika Okazawa-Sakai, Shinichi Okame, Yuko Shiroyama, Takashi Yokoyama, Norihiro Teramoto, Shozo Ohsumi, Shinya Saito, Kazuho Imai, Kokichi Sugano
BACKGROUND: Lynch syndrome is an autosomal dominant inherited disease caused by germline mutations in mismatch repair genes. Analysis for microsatellite instability (MSI) and immunohistochemistry (IHC) of protein expressions of disease-associated genes is used to screen for Lynch syndrome in endometrial cancer patients. When losses of both MLH1 and PMS2 proteins are observed by IHC, MLH1 promoter methylation analysis is conducted to distinguish Lynch syndrome-associated endometrial cancer from sporadic cancer...
May 21, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29783721/azd1775-increases-sensitivity-to-olaparib-and-gemcitabine-in-cancer-cells-with-p53-mutations
#9
Xiangbing Meng, Jianling Bi, Yujun Li, Shujie Yang, Yuping Zhang, Mary Li, Haitao Liu, Yiyang Li, Megan E Mcdonald, Kristina W Thiel, Kuo-Kuang Wen, Xinhao Wang, Meng Wu, Kimberly K Leslie
Tumor suppressor p53 is responsible for enforcing cell cycle checkpoints at G1/S and G2/M in response to DNA damage, thereby allowing both normal and tumor cells to repair DNA before entering S and M. However, tumor cells with absent or mutated p53 are able to activate alternative signaling pathways that maintain the G2/M checkpoint, which becomes uniquely critical for the survival of such tumor cells. We hypothesized that abrogation of the G2 checkpoint might preferentially sensitize p53-defective tumor cells to DNA-damaging agents and spare normal cells with intact p53 function...
May 19, 2018: Cancers
https://www.readbyqxmd.com/read/29783035/estrogen-receptor-progesterone-receptor-cd8-expression-in-endometrium-of-women-of-unexplained-infertility
#10
Shilpi Gupta Dixit, Surajit Ghatak, Pratibha Singh, Shilajit Bhattacharya
OBJECTIVE: The present study aimed to investigate the changes of endometrial progesterone and estrogen receptors in luteal phase biopsy specimens of infertile women and find a correlation, if any, between these and CD8+ receptors in the same. METHODS: The study was conducted on luteal phase endometrial biopsy specimens of 30 women of Unexplained Infertility and 15 age matched controls. Paraffin sections were first H & E stained. A standardized immunohistochemical protocol was then used to localize the estrogen, progesterone and CD8+ receptors in these samples that were expressed as percentage positivity...
May 18, 2018: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29782643/lifetime-number-of-years-of-menstruation-as-a-risk-index-for-postmenopausal-endometrial-cancer-in-the-norwegian-women-and-cancer-study
#11
Oxana Gavrilyuk, Tonje Braaten, Elisabete Weiderpass, Idlir Licaj, Eiliv Lund
INTRODUCTION: Lifetime number of years of menstruation (LNYM) reflects a woman's cumulative exposure to endogenous estrogen and can be used as a measure of the combined effect of reproductive factors related to endometrial cancer (EC) risk. MATERIAL AND METHODS: We aimed to study the association between LNYM and EC risk among postmenopausal women and calculate the population attributable fraction of EC for different LNYM categories. Our study sample consisted of 117 589 women from the Norwegian Women and Cancer (NOWAC) Study...
May 21, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29781387/estrogen-related-receptor-alpha-triggers-the-migration-and-invasion-of-endometrial-cancer-cells-via-up-regulation-of-tgfb1
#12
Xiumin Huang, Xuelian Wang, Jing Shang, Zhiqin Zhaang, Binbin Cui, Yanzhen Lin, Ying Yang, Youyi Song, Shengnan Yu, Junjie Xia
Estrogenic signals have been suggested to be important for the tumorigenesis and progression of endometrial cancer (EC) cells. Our present data showed that estrogen related receptor alpha (ERRα), while not ERRβ or ERRγ, was significantly elevated in EC cells and tissues when compared to their controls. Targeted inhibition of ERRα by siRNA or its inverse agonist XCT-790 can suppress the migration and invasion of EC cells. Both si-ERRα and XCT-790 decreased the expression of transforming growth factor-beta (TGF-β)...
May 21, 2018: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/29780815/endometriosis-malignant-transformation-epigenetics-as-a-probable-mechanism-in-ovarian-tumorigenesis
#13
REVIEW
Jiaxing He, Weiqin Chang, Chunyang Feng, Manhua Cui, Tianmin Xu
Endometriosis, defined as the presence of ectopic endometrial glands and stroma outside the uterine cavity, is a chronic, hormone-dependent gynecologic disease affecting millions of women across the world, with symptoms including chronic pelvic pain, dysmenorrhea, dyspareunia, dysuria, and subfertility. In addition, there is well-established evidence that, although endometriosis is considered benign, it is associated with an increased risk of malignant transformation, with the involvement of various mechanisms of development...
2018: International Journal of Genomics
https://www.readbyqxmd.com/read/29780028/induced-endometrial-trauma-endometrial-scratch-in-the-mid-luteal-menstrual-cycle-phase-preceding-first-cycle-ivf-icsi-versus-usual-ivf-icsi-therapy-study-protocol-for-a-randomised-controlled-trial
#14
Clare Pye, Robin Chatters, Judith Cohen, Kate Brian, Ying C Cheong, Susan Laird, Lamiya Mohiyiddeen, Jonathan Skull, Stephen Walters, Tracey Young, Mostafa Metwally
INTRODUCTION: Endometrial trauma commonly known as endometrial scratch (ES) has been shown to improve pregnancy rates in women with a history of repeated implantation failure undergoing in vitro fertilisation (IVF), with or without intracytoplasmic sperm injection (ICSI). However, the procedure has not yet been fully explored in women having IVF/ICSI for the first time. This study aims to examine the effect of performing an ES in the mid-luteal phase prior to a first-time IVF/ICSI cycle on the chances of achieving a clinical pregnancy and live birth...
May 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29779939/endometrial-carcinoma-in-a-single-horn-of-a-bicornuate-uterus-a-case-report
#15
Khaled Gaballa, Carla Cicero, Valerio Gallotta, Gianfranco Zannoni, Giovanni Scambia
We discuss the diagnosis and the management of endometrial carcinoma in a single horn of bicornuate uterus in a 64-year-old woman as a case report. The case underwent laparoscopic radical hysterectomy and bilateral iliac lymphadenectomy. The gross examination of the uterus revealed a bicornuate uterus with a greater horn of 12 × 9 × 8 cm and a smaller horn of 10 × 3 cm. The cavity of the greater horn showed a neoplastic growth of 10 cm with infiltration of about 1,8 cm of the myometrium from whole thickness of 1...
May 17, 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29779473/activation-of-the-cxcl16-cxcr6-axis-by-tnf-%C3%AE-contributes-to-ectopic-endometrial-stromal-cells-migration-and-invasion
#16
Yaoming Peng, Junyan Ma, Jun Lin
The activation of systemic and local inflammatory mechanisms, including elevated levels of chemokines and proinflammatory cytokines in endometriosis progression, is becoming more evident in the recent years. Here, we report the involvement of CXC chemokine 16 (CXCL16) and its sole receptor, CXC chemokine receptor 6 (CXCR6), in pathophysiology of endometriosis. Expression of CXCL16, but not CXCR6, was significantly upregulated in endometriotic lesions when compared to control endometrium. Additionally, serum CXCL16 was significantly elevated in women with endometriosis when compared to control group...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29778507/factors-associated-with-outcomes-and-inpatient-90-day-cost-of-care-in-endometrial-cancer-patients-undergoing-hysterectomy-implications-for-bundled-care-payments
#17
Aimee Rolston, Ryan J Spencer, R Kevin Reynolds, Laurel W Rice, Shitanshu Uppal
OBJECTIVE: To investigate the association of obesity and other comorbidities as well as route of surgery with postoperative outcomes, as well as 30- and 90-day inpatient cost of care after hysterectomy for endometrial cancer. METHODS: From the 2013 National Readmission Database release, patients who underwent hysterectomy for endometrial cancer were included. Obesity was classified as non-obese (body mass index [BMI] < 35 kg/m2 ); class I/II obesity (BMI ≥ 35 but <40 kg/m2 and without obesity related medical condition qualifying it as morbid obesity), class III obesity (BMI ≥ 40 kg/m2 OR BMI ≥ 35 kg/m2 with an obesity-related medical condition)...
May 16, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29778458/noninvasive-diagnosis-of-endometriosis-review-of-current-peripheral-blood-and-endometrial-biomarkers
#18
REVIEW
Dorien F O, Idhaliz Flores, Etienne Waelkens, Thomas D'Hooghe
A noninvasive biomarker-based test could help shorten the diagnostic delay for endometriosis. The most investigated biomarker sources are peripheral blood and endometrium. Discovery of endometriosis biomarkers is often hypothesis-driven, i.e. when one or a few biomarkers are investigated based on their role in the disease pathogenesis. Alternatively, a hypothesis-generating approach has been followed using the "omics" technologies. A variety of biomarkers for endometriosis have been investigated, but no biomarker has been validated for clinical use...
April 13, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29778382/comparison-of-the-prevalence-of-chronic-endometritis-as-determined-by-means-of-different-diagnostic-methods-in-women-with-and-without-reproductive-failure
#19
Yingyu Liu, Xiaoyan Chen, Jin Huang, Chi-Chiu Wang, Mei-Yung Yu, Susan Laird, Tin-Chiu Li
OBJECTIVE: To compare the prevalence of chronic endometritis (CE) when different diagnostic methods are used. DESIGN: Prospective observational study. SETTING: University-affiliated hospital. PATIENT(S): Four groups of women were studied, including women with proven fertility (Fertile; n = 40), unexplained recurrent miscarriage (RM; n = 93), recurrent implantation failure (RIF; n = 39), and infertile subjects undergoing endometrial scratch in a natural cycle preceding frozen-thawed embryo transfer (Infertility; n = 48)...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29778369/programming-the-endometrium-for-deferred-transfer-of-cryopreserved-embryos-hormone-replacement-versus-modified-natural-cycles
#20
REVIEW
Eva R Groenewoud, Bernard J Cohlen, Nicholas S Macklon
Over the last decade the use of frozen-thawed embryo transfer has substantially increased, and currently up to one in two embryos transferred has been cryopreserved. To support implantation, endometrial and embryo maturity are required to be synchronized. This can be achieved in various ways. The most commonly applied endometrial preparation methods are the "natural cycle," in which the sequential estrogen and P necessary for endometrial maturation are derived from the developing follicle, and the "artificial" cycle, in which these are sequentially administered...
May 2018: Fertility and Sterility
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