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https://www.readbyqxmd.com/read/29775716/ovalbumin-as-a-carrier-to-significantly-enhance-the-aqueous-solubility-and-photostability-of-curcumin-interaction-and-binding-mechanism-study
#1
Yujia Liu, Yanxue Cai, Danyang Ying, Yinlian Fu, Yahong Xiong, Xueyi Le
Egg ovalbumin (OVA) as a macromolecular carrier has the potential to improve the solubility and stability of insolubility bioactive molecules, however, their binding behavior and the mechanism is still ambiguous. In this work, the curcumin was selected as the target to study the interaction and binding mechanism between curcumin and OVA by thermodynamic titration technique in combination with molecular dynamic simulation. The results suggested that the binding included two steps: first, curcumin molecule entered into the hydrophobic pocket of OVA by hydrophobic interaction; and second the interaction was enhanced via hydrogen bonds, resulting in static fluorescence quenching and secondary structural change of OVA...
May 15, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29775556/let-s-talk-about-it-supporting-family-communication-during-end-of-life-care-of-pediatric-patients
#2
Meghan L Marsac, Christine Kindler, Danielle Weiss, Lindsay Ragsdale
BACKGROUND: Communication is key in optimizing medical care when a child is approaching end of life (EOL). Research is yet to establish best practices for how medical teams can guide intrafamily communication (including surviving siblings) when EOL care is underway or anticipated for a pediatric patient. While recommendations regarding how medical teams can facilitate communication between the medical team and the family exist, various barriers may prevent the implementation of these recommendations...
May 18, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29775550/palliative-sedation-with-oral-medicines-in-an-infant-with-generalized-severe-junctional-epidermolysis-bullosa
#3
Keith P Pasichow, Meg Frizzola, Elissa G Miller
Generalized severe junctional epidermolysis bullosa is a rare mechanobullous skin disorder that is uniformly fatal. We present the case of an infant who received palliative pain management and ultimately proportionate palliative sedation. However, because of the extent of the patient's skin disease, we were unable to provide palliative medication through parenteral routes. We discuss the provision of enteral palliative sedation, including the pharmacology, and creative use of medications to achieve sufficient palliation in this difficult and unique situation...
May 18, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29775513/conflicting-priorities-observation-of-medicines-administration
#4
Johanne Alteren, Marit Hermstad, Jo White, Susan Jordan
AIMS AND OBJECTIVES: To identify sources of interruptions and distractions to medicine administration rounds in hospitals. BACKGROUND: Nurses are frequently interrupted during medicine administration. There is no systematic description of nurses' behaviours and interruptions during administration of medicines to patients. DESIGN: Exploratory non-participant observational study. METHODS: Three hundred and fifty-one episodes of medicines administration with 32 nurses from three hospitals in Norway were observed using paper-based observation grids between December 2013 and March 2014...
May 18, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29775465/a-nocturnal-rail-with-a-simple-territorial-call-eavesdrops-on-interactions-between-rivals
#5
Lucyna Ewa Wojas, Paweł Wojciech Podkowa, Tomasz Stanisław Osiejuk
The behaviour of most animals has evolved in a communication network environment, in which signals produced by senders are perceived by many intended and unintended receivers. In this study, we tested whether the corncrake (Crex crex), a nocturnal rail species with innate (non-learned) calls, is able to eavesdrop on the interactions of conspecific males and how this eavesdropping affects subsequent responses by the eavesdropper to territorial intrusion. In the first step, simulated aggressive or neutral interactions between male dyads were presented to a focal male...
2018: PloS One
https://www.readbyqxmd.com/read/29775464/biochemical-characterization-of-recbcd-enzyme-from-an-antarctic-pseudomonas-species-and-identification-of-its-cognate-chi-%C3%AF-sequence
#6
Theetha L Pavankumar, Anurag K Sinha, Malay K Ray
Pseudomonas syringae Lz4W RecBCD enzyme, RecBCDPs, is a trimeric protein complex comprised of RecC, RecB, and RecD subunits. RecBCD enzyme is essential for P. syringae growth at low temperature, and it protects cells from low temperature induced replication arrest. In this study, we show that the RecBCDPs enzyme displays distinct biochemical behaviors. Unlike E. coli RecBCD enzyme, the RecD subunit is indispensable for RecBCDPs function. The RecD motor activity is essential for the Chi-like fragments production in P...
2018: PloS One
https://www.readbyqxmd.com/read/29775400/evaluating-the-cytotoxicity-of-tin-dioxide-nanofibers
#7
Ashley S Reynolds, Tanya H Pierre, Rebecca McCall, Ji Wu, Worlanyo E Gato
Tin dioxide nanofibers (SnDNFs) are small fibers that have many applications. Tin dioxide nanofibers can be used in cosmetics, solar cells, toxic gas release sensors, and air pollution control. To date there have been few studies on the cytotoxicity of SnDNFs. The goal of this research is to determine if electrospun SnDNFs are toxic in a lung cancer cell line (A549). Considering the nano-scale size of the fibers, they can easily be inhaled and enter the pulmonary system and cause toxic effects in the lung. Occupational exposure to SnDNFs has been linked to pulmonary disease, making the A549 cell line important in this study...
May 18, 2018: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/29775237/yolk-accumulation-in-an-insect-oocyte
#8
Isabela Ramos
Oocytes are remarkable cells in the matter of accumulating macronutrients. Oviparous animals have evolved to produce germline cells that not only enter meiosis to generate a gamete, but also differentiate into a giant cell designed to support embryo growth. To accomplish that, an oocyte typically grows up to 5,000x its original size by accumulating macromolecules, which are collectively referred to as yolk. This article is protected by copyright. All rights reserved.
May 18, 2018: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/29775083/comparing-efficacy-of-enteral-nutrition-plus-ranitidine-and-enteral-nutrition-alone-as-stress-ulcer-prophylaxis
#9
Anahid Nourian, Mostafa Mohammadi, Mohammad-Taghi Beigmohammadi, Mohammad Taher, Zohreh Dadvar, Masoume Malekolkottab, Masoud Ramezani, Hossein Khalili
AIM: Adequacy of enteral nutrition (EN) alone as stress ulcer prophylaxis (SUP) is controversial. The aim of this study was to compare efficacy of EN alone and ranitidine plus EN as SUP. METHOD: Critically ill adults with indications to receive SUP were randomized to ranitidine 50 mg IV every 8 h plus EN (SUP) or EN alone (non-SUP) group for 7 days. Besides, endoscopy was performed at the time of recruitment and on day 7. RESULTS: During the study period, only one patient in each group of SUP and non-SUP experienced gastrointestinal bleeding...
May 18, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/29774959/authorship-trends-in-the-journal-of-orthopaedic-research-a-bibliometric-analysis
#10
Abhijit Seetharam, Mohammed T Ali, Christine Y Wang, Katherine E Schultz, James P Fischer, Shatoria Lunsford, Elizabeth C Whipple, Randall T Loder, Melissa A Kacena
Publications are an important tool to measure one's success and achievement in academia. They can help propel a career forward and move one into a position of leadership. The overall purpose of this study was to investigate changes in bibliometric variables, authorship, and collaboration trends in the Journal of Orthopaedic Research (JOR®), since its inception in 1983. A bibliometric analysis was completed for all manuscripts meeting the inclusion criteria (638), which were published throughout the inaugural year plus one representative year of each decade...
May 18, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29774829/novel-parvovirus-related-to-primate-bufaviruses-in-dogs
#11
Vito Martella, Gianvito Lanave, Eszter Mihalov-Kovács, Szilvia Marton, Renáta Varga-Kugler, Eszter Kaszab, Barbara Di Martino, Michele Camero, Nicola Decaro, Canio Buonavoglia, Krisztián Bányai
A novel protoparvovirus species, related genetically to human bufaviruses, was identified in dogs with respiratory signs. The canine bufavirus was distantly related to the well-known canine protoparvovirus, canine parvovirus type 2, sharing low amino acid identities in the nonstructural protein 1 (40.6%) and in the capsid protein 1 (33.4%). By screening collections of fecal, nasal, and oropharyngeal samples obtained from juvenile dogs (<1 year of age), canine bufavirus DNA appeared as a common component of canine virome...
June 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29774822/partial-nephrectomy-in-central-renal-tumors
#12
Sohrab Arora, Craig Rogers
Nephron-sparing surgery, especially through a minimally invasive approach, is increasingly being performed for incidentally detected renal masses with excellent outcomes. Tumors in central location remain a surgical challenge during nephron-sparing surgery. In this chapter, we discuss the minimally invasive management of these tumors, which include complex hilar tumors and endophytic central tumors, with a focus on surgical technique. The key to management of these tumors is to maintain good preoperative hydration, achieving adequate exposure of tumor, and the use of intraoperative ultrasound to plan the resection plane...
May 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29773924/mercury-in-the-diatoms-of-various-ecological-formations
#13
Magdalena Bełdowska, Aleksandra Zgrundo, Justyna Kobos
Mercury is a neurotoxin, its main source in the human organism being fish and seafood. The first level in the marine food web is formed of planktonic and benthic photosynthetic microorganisms, which form a biofilm on the surface of the hard bottom (epilithon) or plants (epiphyton). They are carriers of nutritional as well as toxic substances and pass these on to subsequent levels of the trophic web. Their biomass is often dominated by diatoms. This was the basis for the presented study into Hg accumulation in epilithic, epiphytic and planktonic diatoms, which was carried out in 2012-2013 in the coastal zone of the Puck Lagoon and the Gulf of Gdańsk (southern Baltic)...
2018: Water, Air, and Soil Pollution
https://www.readbyqxmd.com/read/29773815/the-trimeric-solution-structure-and-fucose-binding-mechanism-of-the-core-fucosylation-specific-lectin-phosl
#14
Kazuhiko Yamasaki, Tomoko Yamasaki, Hiroaki Tateno
The core α1-6 fucosylation-specific lectin from a mushroom Pholiota squarrosa (PhoSL) is a potential tool for precise diagnosis of cancers. This lectin consists of only 40 amino acids and can be chemically synthesized. We showed here that a synthesized PhoSL peptide formed a trimer by gel filtration and chemical cross-linking assays, and determined a structure of the PhoSL trimer by NMR. The structure possesses a β-prism motif with a three-fold rotational symmetry, where three antiparallel β-sheets are tightly connected by swapping of β-strands...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29773499/study-of-condylar-positional-changes-after-sagittal-split-osteotomy-for-mandibular-advancement-a-prospective-cohort-study
#15
Alberto Costas, Jacinto F Sanromán, Pilar Castro, Martín F Ferro, Annahys Lopez, Bogdan Stavaru
PURPOSE: To analyse the possible morphologic and positional changes of the mandibular condyles after orthognathic surgery. MATERIAL AND METHODS: A prospective cohort study was performed. Patients with mandibular retrognathism were surgically treated to advance the mandible. The study group included seventeen patients (34 condyles) treated with sagittal split osteotomies alone (4 patients) or in combination with maxillary osteotomies (13 patients). Only condyles located on the mandibular side that advance during surgery were studied, therefore only 25 condyles entered this prospective study...
April 22, 2018: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29773145/pathological-and-molecular-characterization-of-systemic-isosporosis-atoxoplasmosis-in-captive-green-winged-saltator-saltator-similis
#16
Ayisa Rodrigues de Oliveira, Tayse Domingues de Souza, Juliana P S Mol, Mayra Cunha Flecher, Emy Hiura, Renato Lima Santos
Systemic isosporosis, also called atoxoplasmosis or visceral coccidiosis, is a disease that affects birds in general. Pathogenesis of systemic isosporosis and its etiologic agent have not been well characterized, but taxonomically Atoxoplasma is currently considered a junior objective synonym of Isospora. The present report aimed to describe pathological and molecular findings of systemic isosporosis in captive green-winged saltators (Saltator similis) from the State of Espírito Santo, Brazil. In a commercial breeding facility eleven birds with two to nine months of age died from 2015 to 2016...
May 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29772756/developing-an-acoustic-sensing-yarn-for-health-surveillance-in-a-military-setting
#17
Theodore Hughes-Riley, Tilak Dias
Overexposure to high levels of noise can cause permanent hearing disorders, which have a significant adverse effect on the quality of life of those affected. Injury due to noise can affect people in a variety of careers including construction workers, factory workers, and members of the armed forces. By monitoring the noise exposure of workers, overexposure can be avoided and suitable protective equipment can be provided. This work focused on the creation of a noise dosimeter suitable for use by members of the armed forces, where a discrete dosimeter was integrated into a textile helmet cover...
May 17, 2018: Sensors
https://www.readbyqxmd.com/read/29772709/observations-on-the-early-establishment-of-foliar-endophytic-fungi-in-leaf-discs-and-living-leaves-of-a-model-woody-angiosperm-populus-trichocarpa-salicaceae
#18
Yu-Ling Huang, Naupaka B Zimmerman, A Elizabeth Arnold
Fungal endophytes are diverse and widespread symbionts that occur in the living tissues of all lineages of plants without causing evidence of disease. Culture-based and culture-free studies indicate that they often are abundant in the leaves of woody angiosperms, but only a few studies have visualized endophytic fungi in leaf tissues, and the process through which most endophytes colonize leaves has not been studied thoroughly. We inoculated leaf discs and the living leaves of a model woody angiosperm, Populus trichocarpa , which has endophytes that represent three distantly-related genera ( Cladosporium , Penicillium , and Trichoderma )...
May 16, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29772514/the-effect-of-polymer-aging-on-the-uptake-of-fuel-aromatics-and-ethers-by-microplastics
#19
Axel Müller, Roland Becker, Ute Dorgerloh, Franz-Georg Simon, Ulrike Braun
Microplastics are increasingly entering marine, limnic and terrestrial ecosystems worldwide, where they sorb hydrophobic organic contaminants. Here, the sorption behavior of the fuel-related water contaminants benzene, toluene, ethyl benzene and xylene (BTEX) and four tertiary butyl ethers to virgin and via UV radiation aged polypropylene (PP) and polystyrene (PS) pellets was investigated. Changes in material properties due to aging were recorded using appropriate polymer characterization methods, such as differential scanning calorimetry, Fourier transform infrared spectroscopy, gel permeation chromatography, X-ray photoelectron spectroscopy, and microscopy...
May 14, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29771999/growth-medium-dependent-antimicrobial-activity-of-early-stage-mep-pathway-inhibitors
#20
Sara Sanders, David Bartee, Mackenzie J Harrison, Paul D Phillips, Andrew T Koppisch, Caren L Freel Meyers
The in vivo microenvironment of bacterial pathogens is often characterized by nutrient limitation. Consequently, conventional rich in vitro culture conditions used widely to evaluate antibacterial agents are often poorly predictive of in vivo activity, especially for agents targeting metabolic pathways. In one such pathway, the methylerythritol phosphate (MEP) pathway, which is essential for production of isoprenoids in bacterial pathogens, relatively little is known about the influence of growth environment on antibacterial properties of inhibitors targeting enzymes in this pathway...
2018: PloS One
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