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https://www.readbyqxmd.com/read/29166375/gastric-emptying-of-different-meal-volumes-of-identical-composition-in-preterm-infants-a-time-series-analysis
#1
Sharon L Perrella, Anna R Hepworth, Zoya Gridneva, Karen N Simmer, Peter E Hartmann, Donna T Geddes
BACKGROUND: Preterm infants' meals typically progress to higher volumes over time. Knowledge of gastric emptying (GE) responses to differing meal volumes may inform enteral feeding management. We examined the effect of meal volume and composition on preterm GE. METHODS: Forty infants were studied at 33.3±1.4 (29.7-35.6) weeks postmenstrual age when fully enteral fed (target 150 ml/kg/day). Intra-individual comparisons of GE were made for paired meals of 100 and 75% prescribed volume and identical composition of mother's own milk (n=21) and pasteurized donor human milk (n=19)...
November 22, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29166354/smoothing-the-transition-points-in-canadian-medical-education
#2
Nick Busing, Jay Rosenfield, Kamal Rungta, Matt Raegele, Andrew Warren, Bruce Wright, Mark Walton, Ivy Oandasan, Anthony Sanfilippo, Anurag Saxena
In 2010 the Association of Faculties of Medicine of Canada, Collège des médecins du Québec, College of Family Physicians of Canada, and the Royal College of Physicians and Surgeons of Canada launched The Future of Medical Education in Canada Postgraduate (FMEC PG) Project to examine postgraduate medical education (PGME) in Canada and make recommendations for improvement. One recommendation that emerged concerns the transitions learners experience across the undergraduate medical education-PGME-practice continuum...
November 21, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29166353/what-is-the-impact-of-the-underserved-pathway-program-on-graduates-entering-an-underserved-family-medicine-residency-five-year-findings-from-the-university-of-washington-school-of-medicine
#3
Amanda Kost, David Evans, Sharon Dobie, Elizabeth Sanders
PURPOSE: More primary care physicians are needed in underserved areas of the United States. Prior research indicates that medical student experiences in underserved settings increase the likelihood they will practice in underserved areas; few studies have controlled for selection bias. This study aimed to estimate the effect of the University of Washington School of Medicine's (UWSOM's) longitudinal extracurricular experience, the Underserved Pathway (UP), on graduates' choice in entering a family medicine residency with underserved training opportunities...
November 21, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29166238/shiga-toxin-producing-e-coli-infections-associated-with-flour
#4
Samuel J Crowe, Lyndsay Bottichio, Lauren N Shade, Brooke M Whitney, Nereida Corral, Beth Melius, Katherine D Arends, Danielle Donovan, Jolianne Stone, Krisandra Allen, Jessica Rosner, Jennifer Beal, Laura Whitlock, Anna Blackstock, June Wetherington, Lisa A Newberry, Morgan N Schroeder, Darlene Wagner, Eija Trees, Stelios Viazis, Matthew E Wise, Karen P Neil
Background In 2016, a multijurisdictional team investigated an outbreak of Shiga toxin-producing Escherichia coli (STEC) serogroup O121 and O26 infections linked to contaminated flour from a large domestic producer. Methods A case was defined as infection with an outbreak strain in which illness onset was between December 21, 2015, and September 5, 2016. To identify exposures associated with the outbreak, outbreak cases were compared with non-STEC enteric illness cases, matched according to age group, sex, and state of residence...
November 23, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29166105/electrode-reactions-in-slowly-relaxing-media
#5
Dmitry V Matyushov, Marshall D Newton
Standard models of reaction kinetics in condensed materials rely on the Boltzmann-Gibbs distribution for the population of reactants at the top of the free energy barrier separating them from the products. While energy dissipation and quantum effects at the barrier top can potentially affect the transmission coefficient entering the rate pre-exponential factor, much stronger dynamical effects on the reaction barrier are caused by the breakdown of ergodicity for populating the reaction barrier (violation of the Boltzmann-Gibbs statistics)...
November 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29165853/past-year-prescription-drug-monitoring-program-opioid-prescriptions-and-self-reported-opioid-use-in-an-emergency-department-population-with-opioid-use-disorder
#6
Kathryn Hawk, Gail D'Onofrio, David A Fiellin, Marek C Chawarski, Patrick G O'Connor, Patricia H Owens, Michael V Pantalon, Steven L Bernstein
BACKGROUND: Despite increasing reliance on Prescription Drug Monitoring Programs (PDMPs) as a response to the opioid epidemic, the relationship between aberrant drug-related behaviors captured by the PDMP and opioid use disorder is incompletely understood. How PDMP data should guide Emergency Department (ED) assessment has not been studied. STUDY OBJECTIVE: To evaluate a relationship between PDMP opioid prescription records and self-reported non-medical opioid use of prescription opioids in a cohort of opioid dependent ED patients enrolled in a treatment trial...
November 22, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29165744/hypothermia-therapy-after-traumatic-brain-injury-a-systematic-review-and-meta-analysis
#7
Lige Leng
The purpose of this article was mainly focus on in patients with TBI, does or not hypothermia improved mortality and/or chance of good neurologic outcome compared with standard of care alone. We performed a comprehensive search strategy. Articles were eliminated in a stepwise fashion. Data from each study was entered in Review Manager (RevMan) software version 5.0 when reported. 7 studies, including 1331 patients confirmed to all selection criteria and were identified. This meta-analysis got all data of 7 articles together to come to a conclusion, besides that, it also carried on a detailed analysis of different classification, trying to outline the possible mechanism...
October 29, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/29165728/cardioprotective-effect-of-hydroxysafflor-yellow-a-via-the-cardiac-permeability-transition-pore
#8
Gavin A Huber, Sydney M Priest, Timothy P Geisbuhler
Myocardial ischemia damages cardiac myocytes in part via opening of the mitochondrial permeability transition pore. Preventing this pore's opening is therefore a useful therapeutic goal in treating cardiovascular disease. Hydroxysafflor yellow A has been proposed as a nontoxic alternative to other agents that modulate mitochondrial permeability transition pore opening. In this study, we proposed that hydroxysafflor yellow A prevents mitochondrial permeability transition pore formation in anoxic cardiac myocytes, and thus protects the cell from damage seen during reoxygenation of the cardiac myocytes...
November 17, 2017: Planta Medica
https://www.readbyqxmd.com/read/29165701/the-mechano-chemistry-of-a-monomeric-reverse-transcriptase
#9
Omri Malik, Hadeel Khamis, Sergei Rudnizky, Ariel Kaplan
Retroviral reverse transcriptase catalyses the synthesis of an integration-competent dsDNA molecule, using as a substrate the viral RNA. Using optical tweezers, we follow the Murine Leukemia Virus reverse transcriptase as it performs strand-displacement polymerization on a template under mechanical force. Our results indicate that reverse transcriptase functions as a Brownian ratchet, with dNTP binding as the rectifying reaction of the ratchet. We also found that reverse transcriptase is a relatively passive enzyme, able to polymerize on structured templates by exploiting their thermal breathing...
November 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29165666/differences-in-outcomes-over-time-with-exclusive-enteral-nutrition-compared-to-steroids-in-children-with-mild-to-moderate-crohn-s-disease-results-from-the-growth-cd-study
#10
Noa Cohen-Dolev, Malgorata Sladek, Seamus Hussey, Dan Turner, Gabor Veres, Sibylle Koletzko, Javier Martin de Carpi, Annamaria Staiano, Ron Shaoul, Paolo Lionetti, Jorge Amil Dias, Anders Paerregaard, Federica Nuti, Tamar Pfeffer Gik, Tomer Ziv-Baran, Sivan Ben Avraham Shulman, Chen Sarbagili Shabat, Rotem Sigall Boneh, Richard K Russell, Arie Levine
Background: Exclusive enteral nutrition (EEN) and corticosteroids (CS) both induce similar rates of remission in mild to moderate pediatric Crohn's disease (CD), but differ with regard to mucosal healing. Our goal was to evaluate if EEN at diagnosis was superior to CS for improving long term outcomes. Methods: We prospectively followed newly diagnosed children <17 years with mild to moderate disease at baseline for two years in the GROWTH CD study. Patients were evaluated at baseline and at 8, 12, 78, and 104 weeks...
November 18, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29165512/-antiretroviral-treatment-adherence-for-hiv-aids-in-women-a-sociocultural-perspective
#11
Julieta Belmar, Valeria Stuardo
BACKGROUND: Adequate adherence to HAART has a high impact on survival of AIDA patients. There is little consensus on the causes of low adherence to treatment in women, who are in a situation of inequality in terms of prevention and related care. OBJECTIVES: To explore and describe the socio-cultural aspects related to the adherence of women to antiretroviral treatment for HIV / AIDS. MATERIAL AND METHODS: Qualitative, exploratory-descriptive study...
August 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29165431/spinal-accessory-nerve-preservation-in-modified-neck-dissections-surgical-and-functional-outcomes
#12
V Popovski, A Benedetti, D Popovic-Monevska, A Grcev, A Stamatoski, J Zhivadinovik
The spinal accessory nerve (SAN) or XI cranial nerve is frequently encountered during neck surgery, and as such is at risk of iatrogenic injury, resulting in "shoulder syndrome". Modified neck dissection (MND) with preservation of the SAN is based on desire to minimise the functional deformity associated with section of the eleventh nerve. The aim of this study was to analyse the intra-operative variations of the spinal accessory nerve pathway and to evaluate shoulder dysfunction postoperatively. The cross-sectional demonstration analysis was created through the medical records retrospectively of 165 consecutive patients who underwent neck dissections at our institution in the past 5 years with attention to ultrasound and MRI preoperative findings, type of neck dissection, type of identification and dissection of SAN, postoperative morbidity and survival rate...
October 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/29165220/epidemiological-and-experimental-evidence-for-sex-dependent-differences-in-the-outcome-of-leishmania-infantum-infection
#13
Nilda E Rodríguez, Iraci D Lima, Upasna Gaur Dixit, Elizabeth A Turcotte, Ryan D Lockard, Hemali Batra-Sharma, Eliana L Nascimento, Selma M B Jeronimo, Mary E Wilson
Leishmania infantum causes visceral leishmaniasis (VL) in Brazil. We previously observed that VL is more common in males than females living in endemic neighborhoods, despite similar exposure. Using a larger sample, we document that VL is more common in males than females, but only after puberty. BALB/c and C57BL/6 mouse models confirmed that there is a biological basis for male susceptibility to symptomatic VL, showing higher parasite burdens in males than females. Female C57BL/6 mice generated more antigen-induced cytokines associated with curative responses (interferon-γ, interleukin [IL]-1β)...
November 20, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29165214/fecal-contamination-on-produce-from-wholesale-and-retail-food-markets-in-dhaka-bangladesh
#14
Angela R Harris, Mohammad Aminul Islam, Leanne Unicomb, Alexandria B Boehm, Stephen Luby, Jennifer Davis, Amy J Pickering
Fresh produce items can become contaminated with enteric pathogens along the supply chain at the preharvest (e.g., irrigation water, soil, fertilizer) or postharvest (e.g., vendor handling or consumer handling) stages. This study assesses the concentrations of fecal indicator bacteria Escherichia coli, enterococci (ENT), and Bacteriodales on surfaces of carrots, eggplants, red amaranth leaves, and tomatoes obtained from both a wholesale market (recently harvested) and neighborhood retail markets in Dhaka, Bangladesh...
November 20, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29165053/pathophysiology-of-enteral-feeding-diarrhea-the-intestinal-responses-to-enteral-feeding-rather-than-any-role-of-fodmaps
#15
David B A Silk, Tim Bowling
No abstract text is available yet for this article.
November 2017: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29165046/phytophthora-parasitica-effector-pprxlr2-suppresses-nicotiana-benthamiana-immunity
#16
Ronaldo J D Dalio, Heros José Máximo, Tiago Silva Oliveira, Renata Dias, Michele Breton, Henrique Leme Felizatti, Marcos Antonio Antonio Machado
Phytophthora species secrete several classes of effector proteins during interaction with their hosts. These proteins can have multiple functions including modulation of host physiology and immunity. The RxLR effectors have the ability to enter plant cells using the plant machinery. Some of these effectors have been characterized as immunity suppressors; however, very little is known about their functions in the interaction between Phytophthora parasitica and its hosts. Using a bioinformatics pipeline, we have identified 172 candidate RxLR effectors (CREs) in the isolate IAC 01_95 of P...
November 22, 2017: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/29164960/a-randomized-open-label-study-to-evaluate-an-intermittent-dosing-regimen-of-fluticasone-propionate-0-05-cream-in-combination-with-regular-emollient-skin-care-in-reducing-the-risk-of-relapse-in-pediatric-patients-with-stabilized-atopic-dermatitis
#17
Lian Liu, Gary Ong
BACKGROUND: Atopic dermatitis (AD) is a chronic, relapsing disease that requires maintenance treatment. This study examined the efficacy and safety of extended intermittent fluticasone propionate (FP) 0.05% cream, with emollient, vs emollient alone in children with AD. METHODS: Eligible patients (aged 1-17 years) received FP 0.05% cream twice daily for 4 weeks (acute phase) then randomized (1:1) to FP 0.05% cream once daily, twice per week plus emollient (Group A) or emollient alone (Group B) for up to 20 weeks (maintenance phase)...
November 22, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29164566/drug-related-oral-malodour-halitosis-a-literature-review
#18
M Torsten, G Gómez-Moreno, A Aguilar-Salvatierra
Dry mouth (xerostomia), is a fairly common, well-researched condition, which is an indirect cause of oral malodour. This systematic literature review looked into another cause of bad breath: adverse drug reactions in the orofacial region causing halitosis. The study focused on extraoral halitosis, and its subdivisions, particularly blood borne halitosis in which malodourous compounds in the blood stream are carried to the lungs, passively diffused across the pulmonary alveolar membrane to enter the breath. An electronic search was conducted in various databases...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164459/deposition-acute-toxicity-and-bioaccumulation-of-nickel-in-some-freshwater-organisms-with-best-fit-functions-modeling
#19
Anupam Ghosh, Anilava Kaviraj, Subrata Saha
Although nickel (Ni) frequently enters into water, documents on speciation of the metal and its toxicity to freshwater organisms are scanty. Laboratory experiments, made in this study, with 1.0-5.0 mg/L of Ni revealed that Ni was not quickly removed from water. Application of cubic regression followed by classical optimization technique showed that maximum reduction time (T) of Ni in water ranged between 60 to 65 h. Ninety-six hours of LC50 value of Ni to crustacean Diaptomus forbesi, fish Cyprinus carpio, and worm Branchiura sowerbyi was respectively 5...
November 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29164350/predictors-of-partial-hospital-readmission-for-young-children-with-oppositional-defiant-disorder
#20
John R Boekamp, Richard T Liu, Sarah E Martin, Lauren R Mernick, Mia DeMarco, Anthony Spirito
This study aimed to: (1) examine rates of readmission among young children with oppositional defiant disorder (ODD) following discharge from a psychiatric partial hospital treatment program, and (2) examine child factors (i.e., age, sex, co-occurring diagnoses, suicidality) and family factors (i.e., parental depression, stress) as prospective predictors of readmission. Participants were 261 children (ages 3-7 years) who entered the study at the time of their initial program admission and who met DSM-IV criteria for ODD...
November 21, 2017: Child Psychiatry and Human Development
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