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https://www.readbyqxmd.com/read/29353316/validation-of-a-new-classification-for-periprosthetic-shoulder-fractures
#1
Chlodwig Kirchhoff, Marc Beirer, Ulrich Brunner, Arne Buchholz, Peter Biberthaler, Moritz Crönlein
INTRODUCTION: Successful treatment of periprosthetic shoulder fractures depends on the right strategy, starting with a well-structured classification of the fracture. Unfortunately, clinically relevant factors for treatment planning are missing in the pre-existing classifications. Therefore, the aim of the present study was to describe a new specific classification system for periprosthetic shoulder fractures including a structured treatment algorithm for this important fragility fracture issue...
January 20, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29353019/induction-by-innate-defence-regulator-peptide-1018-of-pro-angiogenic-molecules-and-endothelial-cell-migration-in-a-high-glucose-environment
#2
Paulina Marin-Luevano, Valentin Trujillo, Adrian Rodriguez-Carlos, Irma González-Curiel, Jose A Enciso-Moreno, Robert E W Hancock, Bruno Rivas-Santiago
Synthetic innate defence regulator (IDR) peptides such as IDR-1018 modulate immunity to promote key protective functions including chemotaxis, wound healing, and anti-infective activity, while suppressing pro-inflammatory responses to non-pathological levels. Here we demonstrated that IDR-1018 induced, by up to 75-fold, pro-angiogenic VEGF-165 in keratinocytes but suppressed this isoform in endothelial cells. It also induced early angiogenin and prolonged anti-inflammatory TGFβ expression on endothelial cells, while suppressing early pro-inflammatory IL-1β expression levels...
January 15, 2018: Peptides
https://www.readbyqxmd.com/read/29352689/morbidity-and-safety-of-iliac-crest-reference-array-pins-in-navigated-total-hip-arthroplasty-a-prospective-cohort-study
#3
Anton P Lambers, Xiang G Salim, Robert Jennings, Andrew T Bucknill
BACKGROUND: Navigated total hip arthroplasty (THA) can employ intra-osseous pins through a separate incision to secure reference arrays to the iliac crest. This study is the first to investigate the consequences of pin use in THA in vivo. METHODS: A prospective, consecutive series of 43 patients presenting for navigated THA were included. Two temporary 125 × 4 mm Schanz screws were inserted into the iliac crest for the attachment of a reference array. Telephone follow-up occurred at 6 and 12 weeks post-operatively...
December 28, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29352310/leishmania-proteophosphoglycans-regurgitated-from-infected-sand-flies-accelerate-dermal-wound-repair-and-exacerbate-leishmaniasis-via-insulin-like-growth-factor-1-dependent-signalling
#4
Emilie Giraud, Tereza Lěstinová, Tamsyn Derrick, Oihane Martin, Rod J Dillon, Petr Volf, Ingrid Műller, Paul A Bates, Matthew E Rogers
Leishmania parasites are transmitted to vertebrate hosts by female phlebotomine sand flies as they bloodfeed by lacerating the upper capillaries of the dermis with their barbed mouthparts. In the sand fly midgut secreted proteophosphoglycans from Leishmania form a biological plug known as the promastigote secretory gel (PSG), which blocks the gut and facilitates the regurgitation of infective parasites. The interaction between the wound created by the sand fly bite and PSG is not known. Here we nanoinjected a sand fly egested dose of PSG into BALB/c mouse skin that lead to the differential expression of 7,907 transcripts...
January 19, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29351311/the-quality-of-voluntary-medical-male-circumcision-done-by-mid-level-workers-in-tshwane-district-south-africa-a-retrospective-analysis
#5
Sanele Ngcobo, Jacqueline Elizabeth Wolvaardt, Martin Bac, Elize Webb
BACKGROUND: Voluntary medical male circumcision (VMMC) reduces the acquisition of human immunodeficiency virus (HIV) in heterosexual men by up to 60%. One HIV infection is averted for every 5 to 15 VMMCs. To conduct VMMCs in large populations, large numbers of trained healthcare professionals are needed. Countries in Sub-Saharan Africa have a high burden of HIV and a shortage of healthcare professionals, creating a healthcare conundrum. To bridge this gap, South Africa launched a new cadre of mid-level medical worker called Clinical Associates (CA)...
2018: PloS One
https://www.readbyqxmd.com/read/29351052/particulate-coral-hydroxyapatite-sheltered-by-titanium-mesh-for-localized-alveolar-rehabilitation-after-onlay-graft-failure-a-case-report
#6
Miao Zhou, Shuyi Li, Hendrik Terheyden, Shuaishuai Cao, Yuejuan Che, Yuanming Geng
Reconstruction of bone loss in the alveolar ridge has long been challenging. Autologous bone grafts are considered as the "golden standard", while little research has focused on how to repair pronounced alveolar bone defects after autologous bone graft failure. The aim of this study was to detail a method based on the titanium mesh technique coupled with particulate coral hydroxyapatite to solve the Onlay graft failure. With bone deficiency in the #11 and #24- #25 regions, we harvested two autologous bone blocks for reconstruction...
January 19, 2018: Journal of Oral Implantology
https://www.readbyqxmd.com/read/29350654/autolytic-debridement-and-management-of-bacterial-load-with-an-occlusive-hydroactive-deressing-impregnated-with-polyhexamethylene-biguanide
#7
Stefano Mancini, Roberto Cuomo, Mauro Poggialini, Carlo D'Aniello, Giuseppe Botta
BACKGROUND: Debridement and control of bacterial load are key-points of wound care. The aim of this study is to evaluate the effectiveness of autolytic debridement and management of bacterial load (bioburden) of an occlusive hydro-active dressing impregnated with polyhexamethylene biguanide (PHMB). METHODS: We used an occlusive dressing of hydro-active for leg ulcers' treatment (TenderWet-plus® - Hartmann).  Inclusion criteria were: presence of a fibrinous ulcer with multiple etiopathogenesis, in absence of clinical infection, no hypersecretion and diameter within 5 cm...
January 16, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29349984/-risk-factors-analysis-on-wound-complications-after-closed-calcaneal-frature-operation-using-lateral-extensive-l-shaped-incision
#8
Xin-Xing Fan, Yang Shen, Wen-Long Xie
OBJECTIVE: To investigate the risk factors of wound complications after closed calcaneal fracture operation using a lateral extensive L-shaped incision and to explore the effective interventions to reduce the complications after incision. METHODS: Retrospective analysis of clinical data of 285 patients(315 calcaneal fractures) who underwent open reduction and internal fixation by using the lateral extensive L-shaped incision from January 2011 to January 2015. Eighteen factors which might cause the complications of calcaneal incision were compared by univariate analysis, and multiple Logistic regression analysis was performed for factors with statistically significances...
April 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29349982/-effects-of-tranexamic-acid-combined-with-temporary-drain-clamping-on-postoperative-blood-loss-in-total-knee-arthroplasty
#9
Yi-Long Dong, Yue-Nan Qian, Xi-Qiang Zhong, Guang-Jie Shen, Chun-Yuan Cai
OBJECTIVE: To evaluate the efficacy and safety of one dose tranexamic acid combined with temporary drain lamping in primary unilateral total knee arthroplasty. METHODS: Total 160 patients undergoing unilateral primary total knee arthroplasty between January 2012 and December 2013 were randomly divided into four groups(40 cases in each group):group A (the drain was clamped for 2 hours after the operation and the patients received 20 ml physiological saline), group B(the drain was clamped for 2 hours after the operation and the patients received 10 ml tranexamic acid and 10 ml physiological saline), group C (the drain was clamped for 4 hours after the operation and the patients received 20 ml physiological saline) and group D(the drain was clamped for 4 hours after the operation and the patients received 10 ml tranexamic acid and 10 ml physiological saline)...
April 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29349975/-clinical-research-on-the-arthroscopic-treatment-for-recurrent-patellar-dislocation-by-anatomical-reconstruction-of-medial-patellarfemoral-ligament
#10
Zhen-Yang Yu, Xu Cai, Wang Gu
OBJECTIVE: To observe the therapeutic effects of arthroscopic treatment for recurrent patellar dislocation by anatomical reconstruction of medial patellarfemoral ligament. METHODS: From June 2009 to December 2014, 25 patients with recurrent patellar dislocation were treated with anatomical reconstruction of medial patellarfemoral ligament surgery under arthroscopy. There were 10 males and 15 females, with an average age of 18.4 years old (ranged, 15 to 25 years old )...
April 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29349970/-total-thigh-musculocutaneous-flap-in-reconstruction-of-refractory-pressure-ulcers-around-hips-in-patients-with-spinal-cord-injury
#11
Li-Feng Zhai, Li-Feng Shen, Gou-Ping Ma, Qiao-Feng Guo, Chun Zhang
OBJECTIVE: To discuss the treatment of life-threatening refractory pressure ulcers around hips in patients with spinal cord injuries(SCI)and evaluate its clinical outcomes. METHODS: From March 2012 to June 2015, eight paraplegic patients with life-threatening refractory pressure ulcers around hips were treated with total thigh musculocutaneous flaps following amputation of proximal femurs or hips, including 7 males and 1 female with an average age of (52.0±2.6) years old ranging from 35 to 68...
March 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29349969/-early-application-of-the-antibiotic-laden-bone-cement-albc-combined-with-the-external-fixation-support-in-treating-the-open-fractures-of-lower-limbs-complicated-with-bone-defect
#12
Jian Xiao, Zhao-Guang Mao, Hui-Hua Zhu, Liang Guo
OBJECTIVE: To discuss the curative effect of the early application of the antibiotic-laden bone cement (ALBC) combined with the external fixation support in treating the open fractures of lower limbs complicated with bone defect. METHODS: From December 2013 to January 2015, 36 cases of lower limb open comminuted fractures complicated with bone defects were treated by the vancomycin ALBC combined with the external fixation support, including 26 males and 10 females with an average age of 38...
March 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29349616/outcomes-of-utilizing-absorbable-mesh-as-an-adjunct-to-posterior-sheath-closure-during-complex-posterior-component-separation
#13
J S Winder, A Majumder, M Fayezizadeh, Y W Novitsky, E M Pauli
BACKGROUND: A minority of patients undergoing posterior component separation (PCS) have abdominal wall defects that preclude complete reconstruction of the visceral sac with native tissue. The use of absorbable mesh bridges (AMB) to span such defects has not been established. We hypothesized that AMB use during posterior sheath closure of PCS is safe and provides favorable outcomes. METHODS: We performed a retrospective review of consecutive patients undergoing PCS with AMB at two hernia centers...
January 18, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29348331/draft-genome-sequences-of-two-vibrio-parahaemolyticus-strains-associated-with-gastroenteritis-after-raw-seafood-ingestion-in-colorado
#14
Sonya A Trinh, Semen A Leyn, Ivan D Rodionov, Adam Godzik, Karla J F Satchell
Vibrio parahaemolyticus is a Gram-negative pathogen associated with gastrointestinal and wound infections after exposure to raw seafood or contaminated waters. We report here the whole-genome sequences of two stool isolates (CDC-AM50933 and CDC-AM43539) from patients in Colorado presenting with gastroenteritis after ingesting raw seafood.
January 18, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29346827/efficacy-and-complications-of-submucosal-tunneling-endoscopic-resection-for-upper-gastrointestinal-submucosal-tumors-and-exploration-for-influencing-factors
#15
Shunzhe Song, Xu Wang, Shen Zhang, Yanxia Li, Xiaonan Zhang, Xufang Chu
BACKGROUND:  Submucosal tunneling endoscopic resection (STER) has emerged as a feasible technique for resecting upper gastrointestinal (GI) tract submucosal tumors (SMTs) through natural orifice transluminal endoscopic surgery. STER reduces the risk of postoperative perforation and abdominal infections and promotes rapid wound healing. The aim of this meta-analysis was to evaluate the safety and efficacy of STER for small (≤ 3.5 cm) upper GI SMTs and explore the potential factors influencing STER's efficacy and complication rate...
January 18, 2018: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29346824/antimicrobial-chemotherapy-has-a-linear-relationship-to-the-proportion-of-gram-negative-isolates-from-pediatric-burn-wounds
#16
Alexa Welk, Myriam Herrnberger, Veronika Engel, Martin Dennebaum, Christina Oetzmann von Sochaczewski, Stephan Gehring
Wound infection in burns is a relevant cause of morbidity and mortality in children. We aimed to determine the relationship between antibacterial chemotherapy and Gram-negative burn wound colonization and infection. All children admitted to the pediatric intensive care unit for burn trauma from June 1, 2005 to January 31, 2013 were included. We obtained 141 wound samples, of which 88 (65.7%) showed growth of Gram-positive bacteria. Treatment with antimicrobial chemotherapy was necessary in 23 (31.1%) patients...
January 2018: Klinische Pädiatrie
https://www.readbyqxmd.com/read/29345902/flexible-amoxicillin-grafted-bacterial-cellulose-sponges-for-wound-dressing-in-vitro-and-in-vivo-evaluation
#17
Shan Ye, Lei Jiang, Jimin Wu, Chen Su, Chaobo Huang, Xiufeng Liu, Wei Shao
In this study, we report the design and fabrication of a novel biocompatible sponge with excellent antibacterial property, making it a promising material for wound dressings. The sponge is formed by grafting amoxicillin onto regenerated bacterial cellulose (RBC). It was observed that the grafted RBC could enhance the antibacterial activity against fungus, Gram-negative and Gram-positive bacteria. The morphology of strains treated with the grafted RBC and fluorescent stain results further demonstrated the antibacterial ability of the fabricated sponge...
January 18, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29345058/frontline-science-anti-pd-l1-protects-against-infection-with-common-bacterial-pathogens-after-burn-injury
#18
Naeem K Patil, Liming Luan, Julia K Bohannon, Antonio Hernandez, Yin Guo, Edward R Sherwood
Burn patients are susceptible to infections due, in part, to immune dysfunction. Upregulation of programmed death-1 (PD-1) receptor on T cells and programmed cell death ligand-1 (PD-L1) on myeloid cells contribute to immune dysfunction in nonburn-related sepsis. We hypothesized that PD-1/PDL1 interactions contribute to immune dysfunction after burn injury. To determine the impact of burn injury and infection on PD-L1, PD-1 and costimulatory receptor expression by leukocytes and its relationship to T cell functions...
January 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29343956/essential-oil-loaded-lipid-nanoparticles-for-wound-healing
#19
Francesca Saporito, Giuseppina Sandri, Maria Cristina Bonferoni, Silvia Rossi, Cinzia Boselli, Antonia Icaro Cornaglia, Barbara Mannucci, Pietro Grisoli, Barbara Vigani, Franca Ferrari
Chronic wounds and severe burns are diseases responsible for severe morbidity and even death. Wound repair is a crucial process and tissue regeneration enhancement and infection prevention are key factors to minimize pain, discomfort, and scar formation. The aim of this work was the development of lipid nanoparticles (solid lipid nanoparticles and nanostructured lipid carriers [NLC]), to be loaded with eucalyptus or rosemary essential oils and to be used, as medical devices, to enhance healing of skin wounds...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29343818/a-surfactant-polymer-dressing-potentiates-antimicrobial-efficacy-in-biofilm-disruption
#20
Piya Das Ghatak, Shomita S Mathew-Steiner, Priyanka Pandey, Sashwati Roy, Chandan K Sen
A 100% water-soluble surfactant polymer dressing (SPD) that is bio-compatible and non-ionic has been reported to improve wound closure in preliminary clinical studies. The mechanism of action of SPD in wound healing remains unclear. Biofilm infection is a significant problem that hinders proper wound closure. The objective of this study was to characterize the mechanism of action of SPD inhibition of bacterial biofilm development. Static biofilms (48 h) of the primary wound pathogens Pseudomonas aeruginosa (PA01), Staphylococcus aureus (USA300) were grown on polycarbonate membranes and treated with SPD with and without antibiotics for an additional 24 h...
January 17, 2018: Scientific Reports
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