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https://www.readbyqxmd.com/read/28932137/role-of-herpesviruses-in-chronic-periodontitis-and-their-association-with-clinical-parameters-and-in-increasing-severity-of-the-disease
#1
Mohammad Mukhit Abdul Gaffar Kazi, Renu Bharadwaj
OBJECTIVE: This study aims to assess the role of herpesviruses in chronic periodontitis and their association with clinical parameters and in increasing severity. MATERIALS AND METHODS: This was a prospective case-control study. Ethical approval and prior consent were taken. A subgingival plaque sample was collected from a total of 300 patients and 300 controls and processed for DNA extraction and multiplex polymerase chain reaction for detection of herpesviruses...
July 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/28931680/molecular-evolution-of-herpes-simplex-virus-2-complete-genomes-comparison-between-primary-and-recurrent-infections
#2
Miguel A Minaya, Travis Jensen, Johannes Goll, Maria Korom, Sree H Datla, Robert B Belshe, Lynda A Morrison
Herpes simplex virus (HSV)-1 and -2 are large, double-stranded DNA viruses that cause lifelong persistent infections characterized by periods of quiescence and recurrent disease. How HSV evolves within an infected individual experiencing multiple episodes of reactivation over time is not known. We determined genome sequences of viruses isolated from two subjects in the Herpevac Trial for Women who experienced primary HSV-2 genital disease and compared them with sequences of viruses isolated from the subsequent fifth or sixth episode of recurrent disease in the same individuals...
September 20, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28927283/proposed-anti-hsv-compounds-isolated-from-simira-species
#3
Jessica F Cavalcanti, Marcelo F de Araujo, Priscila B Gonçalves, Nelilma C Romeiro, Maria T Villela Romanos, Ivo J Curcino Vieira, Raimundo Braz-Filho, Mário G de Carvalho
Secondary metabolites isolated from Simira eleiezeriana and Simira glaziovii were evaluated against herpes simplex virus (HSV-1) and (HSV-2). The 50% effective concentrations values (EC50) were calculated from the dose-response curve and the selectivity index (SI) against the virus. The physicochemical data LogP, (PSA), (NRB), (HBA) and (HBD) were obtained using Marvin Sketch. Among the tested compounds, conipheraldeyde, harman and simirane A showed better results with EC50 6.39; 4.90; 4.61 µg/mL and SI 78...
September 19, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28926336/extensive-atypical-hsv-2-ulceration-of-the-finger
#4
Nélia Cunha, Pedro Simões, Vasco Serrão
No abstract text is available yet for this article.
August 31, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28914197/characterization-of-inherent-particles-and-mechanism-of-thermal-stress-induced-particle-formation-in-hsv-2-viral-vaccine-candidate
#5
Lillian Li, Marina Kirkitadze, Kamaljit Bhandal, Cristopher Roque, Eric Yang, Bruce Carpick, Nausheen Rahman
BACKGROUND: Vaccine formulations may contain visible and/or subvisible particles, which can vary in both size and morphology. Extrinsic particles, which are particles not part of the product such as foreign contaminants, are generally considered undesirable and should be eliminated or controlled in injectable products. However, biological products, in particular vaccines, may also contain particles that are inherent to the product. Here we focus on the characterization of visible and subvisible particles in a live, replication-deficient viral vaccine candidate against HSV genital herpes in an early developmental stage...
September 14, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28914066/-herpes-simplex-virus-infection-an-overview-of-the-problem-pharmacologic-therapy-and-dietary-measures
#6
Sherif T S Hassan, Miroslava Šudomová, Radka Masarčíková
Treatment of infectious diseases remains one of the principal research target for many researchers and healthcare providers worldwide. Herpes simplex virus 1 (HSV-1) and herpes simplex virus 2 (HSV-2) are common human pathogens with an estimated 60-95% of the adult population infected by at least one of them. The worldwide disease burden of HSV is substantial, and acyclovir and related nucleoside analogues (viral DNA polymerase inhibitors) as therapies have led to significantly increased treatment efficacy of HSV infections...
2017: Ceská a Slovenská Farmacie
https://www.readbyqxmd.com/read/28902907/pcr-detection-of-human-herpesviruses-in-colonic-mucosa-of-individuals-with-inflammatory-bowel-disease-comparison-with-individuals-with-immunocompetency-and-hiv-infection
#7
Takayuki Shimada, Naoyoshi Nagata, Koki Okahara, Akane Joya, Tsunefusa Hayashida, Shinichi Oka, Toshiyuki Sakurai, Junichi Akiyama, Naomi Uemura, Hiroyuki Gatanaga
BACKGROUND: Detection of human herpesviruses (HHVs) other than cytomegalovirus (CMV) in colonic mucosa of individuals with inflammatory bowel disease (IBD) remains unknown. This study identified eight HHVs in the colonic mucosa of individuals with IBD and compared the results with immunocompetent and human immunodeficiency virus (HIV)-infected individuals. METHODS: A total of 89 individuals who had colorectal ulcer on colonoscopy were enrolled: 26 with immunocompetency (n = 26), 41 with IBD, and 22 with HIV infection...
2017: PloS One
https://www.readbyqxmd.com/read/28893956/cutting-edge-genetic-association-between-ifi16-single-nucleotide-polymorphisms-and-resistance-to-genital-herpes-correlates-with-ifi16-expression-levels-and-hsv-2-induced-ifn-%C3%AE-expression
#8
Kristina Eriksson, Alexandra Svensson, Alon S Hait, Kerstin Schlüter, Petra Tunbäck, Inger Nordström, Leonid Padyukov, Jan-Åke Liljeqvist, Trine H Mogensen, Søren R Paludan
IFN-γ-inducible protein 16 (IFI16) is an immunological DNA sensor proposed to act in the cyclic GMP-AMP synthase-stimulator of IFN genes pathway. Because mice do not have a clear ortholog of IFI16, this system is not suitable for genetic studies of IFI16. In this study, we have compared the dependency on IFI16, cyclic GMP-AMP synthase, and stimulator of IFN genes for type I IFN induction by a panel of pathogenic bacteria and DNA viruses. The IFN response induced by HSV-2 was particularly dependent on IFI16...
September 11, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28876290/performance-of-commercial-enzyme-linked-immunoassays-for-diagnosis-of-herpes-simplex-virus-1-and-herpes-simplex-virus-2-infection-in-a-clinical-setting
#9
Elfriede Agyemang, Quynh-An Le, Terri Warren, Amalia S Magaret, Stacy Selke, Christine Johnston, Keith R Jerome, Anna Wald
BACKGROUND: US Food and Drug Administration-approved enzyme-linked immunoassays (EIA) for determining type-specific herpes simplex virus (HSV) serostatus are widely used in clinical practice. We compared the performance of such assays with the University of Washington Western blot (UW WB) in patients who sought confirmation of their HSV serology result. METHODS: We reviewed charts of all persons evaluated at the Westover Heights Clinic in Portland, Oregon, from July 2010 through September 2015, who had a HSV EIA, followed by UW WB...
August 22, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28876288/heterogeneity-of-herpes-simplex-virus-type-2-seroprevalence-from-a-national-probability-survey-in-mexico-2012
#10
Miguel Angel Sanchez-Aleman, Yamira Georgina Del Villar-Tapia, Juan Pablo Gutierrez, Santa Garcia-Cisneros, Ma Leonidez Olamendi-Portugal, Antonia Herrera-Ortiz, Manuel Velazquez-Meza, Carlos J Conde-Glez
BACKGROUND: Herpes simplex virus type 2 (HSV-2) seroprevalence and associated infection risk factors show differences by regions and countries. The aims of the study were to determine the HSV-2 seroprevalence and to evaluate the risk factors for HSV-2 in a national representative survey among adolescents and adults in Mexico. METHODS: A cross-sectional study was carried out in Mexico on the basis of the National Health and Nutrition Survey 2012, a national representative survey...
August 25, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28862190/seroprevalence-of-cytomegalovirus-in-donors-opportunistic-viral-infections-in-liver-transplant-recipients
#11
Joy Varghese, S Subramanian, Mettu Srinivas Reddy, Naresh Shanmugam, G Balajee, Vijaya Srinivasan, Jayanthi Venkataraman, Rela Mohamed
BACKGROUND & OBJECTIVES: Opportunistic virus infections are common in liver transplant (LT) recipients. There is a risk of developing infection with cytomegalovirus (CMV) and herpes-related viruses such as herpes simplex virus-1 and 2 (HSV-1 & 2), Epstein-Barr virus (EBV) and Varicella Zoster virus (VZV), reactivation of infection and recurrent infection. This study was conducted to determine CMV seropositivity in donors and its influence on LT recipients and seropositivity of CMV, HSV-1 and 2, EB viral capsid antigen (EBVCA) and VZV in LT recipients and their reactivation...
April 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28854795/herpes-simplex-viruses-type-1-and-2-photoinactivated-in-the-presence-of-methylene-blue-transform-human-and-mouse-cells-in-vitro
#12
M Michútová, V Mrázová, M Kúdelová, M Smolinská, M Šupoliková, M Vrbová, F Golais
Three strains of herpes simplex virus, K17syn- and HSZPsyn+ of type 1 (HSV-1) and USsyn- of type 2 (HSV-2), were photoinactivated in the presence of methylene blue and used to infect 3 cell lines, normal human lung tissue cells (MRC-5), mouse epithelial cells (NIH3T3), and human lung carcinoma cells (A549). The virus titer and phenotype of cells were evaluated to compare the characteristics of normal and carcinoma cells infected with non-syncytial (non-syn) and syncytial (syn) strains of herpes simplex viruses...
2017: Acta Virologica
https://www.readbyqxmd.com/read/28852985/comparison-of-acyclovir-and-multistrain-lactobacillus-brevis-in-women-with-recurrent-genital-herpes-infections-a-double-blind-randomized-controlled-study
#13
Amir Hossein Mohseni, Sedigheh Taghinezhad-S, Hossein Keyvani, Narges Ghobadi
We performed a randomized double-blind controlled trial to compare the efficacy and safety of multistrain probiotic and acyclovir in women patients with recurrent genital herpes simplex virus type 2 (HSV-2) infections. Eighty-one patients enrolled in the study were being treated with multistrain Lactobacillus brevis one vaginal capsule every 12 h and oral acyclovir 400 mg twice daily for 6 months. Of 53 patients who completed both treatment courses, no important differences were identified between acyclovir and probiotic for the primary and secondary efficacy endpoint, resolution of episode (hazard ratio, 0...
August 30, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28843576/effect-of-hsv-2-infection-on-subsequent-hiv-acquisition-an-updated-systematic-review-and-meta-analysis
#14
Katharine J Looker, Jocelyn A R Elmes, Sami L Gottlieb, Joshua T Schiffer, Peter Vickerman, Katherine M E Turner, Marie-Claude Boily
BACKGROUND: HIV and herpes simplex virus type 2 (HSV-2) infections cause a substantial global disease burden and are epidemiologically correlated. Two previous systematic reviews of the association between HSV-2 and HIV found evidence that HSV-2 infection increases the risk of HIV acquisition, but these reviews are now more than a decade old. METHODS: For this systematic review and meta-analysis, we searched PubMed, MEDLINE, and Embase (from Jan 1, 2003, to May 25, 2017) to identify studies investigating the risk of HIV acquisition after exposure to HSV-2 infection, either at baseline (prevalent HSV-2 infection) or during follow-up (incident HSV-2 infection)...
August 23, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28842321/differential-day-night-outcome-to-hsv-2-cutaneous-infection
#15
Takamitsu Matsuzawa, Yuki Nakamura, Youichi Ogawa, Kayoko Ishimaru, Fumi Goshima, Shinji Shimada, Atsuhito Nakao, Tatsuyoshi Kawamura
No abstract text is available yet for this article.
August 22, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28827540/the-us2-gene-product-of-herpes-simplex-virus-2-modulates-nf-%C3%AE%C2%BAb-activation-by-targeting-tak1
#16
Xuan Lu, Changjing Huang, Yi Zhang, Yong Lin, Xueyu Wang, Qian Li, Shi Liu, Jingfeng Tang, Li Zhou
HSV-2 is one of the most common sexually transmitted pathogens worldwide and HSV-2 infection triggers cytokine and chemokine production. However, little is known about which HSV-2 genes engage in the regulation of NF-κB signaling and what mechanisms are involved. In a screen of the unique short (Us) regions of HSV-2, we observed that HSV-2 Us2 activates NF-κB signaling. We additionally indicated that deficiencies of Us2 decrease HSV-2 WT mediated NF-κB activation and cytokine and chemokine production, and overexpression of Us2 showed opposite effects...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821230/seroprevalence-of-herpes-simplex-virus-type-2-hsv-2-among-pregnant-women-who-participated-in-a-national-hiv-surveillance-activity-in-haiti
#17
Jean Wysler Domercant, Frantz Jean Louis, Erin Hulland, Mark Griswold, Jocelyne Andre-Alboth, Tun Ye, Barbara J Marston
BACKGROUND: Herpes simplex virus type 2 (HSV-2), one the most common causes of genital ulcers, appears to increase both the risk of HIV acquisition and HIV transmission. HSV-2/HIV co-infection among pregnant women may increase the risk of perinatal transmission of HIV. This study describes rates of HSV-2 among pregnant women in Haiti and HSV-2 test performance in this population. METHODS: Unlinked residual serum specimens from the 2012 National HIV and Syphilis Sentinel Surveillance Survey among pregnant women in Haiti were tested using two commercial kits (Focus HerpeSelect, Kalon) for HSV-2 antibodies...
August 18, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28809154/interaction-between-herpesvirus-entry-mediator-and-hsv-2-glycoproteins-mediates-hiv-1-entry-of-hsv-2-infected-epithelial-cells
#18
Kai Hu, Siyi He, Juhua Xiao, Mei Li, Sukun Luo, Mudan Zhang, Qinxue Hu
Herpes simplex virus type 2 (HSV-2) increases human immunodeficiency virus type 1 (HIV-1) acquisition and transmission via unclear mechanisms. Herpesvirus entry mediator (HVEM), an HSV-2 entry receptor, is highly expressed on HIV-1 target cells (CD4+ T cells) and may be incorporated into HIV-1 virions, while HSV-2 glycoproteins can be present on the infected cell surface. Since HVEM-gD interaction together with gB/gH/gL is essential for HSV-2 entry, HVEM-bearing HIV-1 (HIV-1/HVEM) may enter HSV-2-infected cells through such interactions...
September 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28807852/extracts-of-equisetum-giganteum-l-and-copaifera-reticulate-ducke-show-strong-antiviral-activity-against-the-sexually-transmitted-pathogen-herpes-simplex-virus-type-2
#19
Marianela Patzi Churqui, Liza Lind, Karolina Thörn, Alexandra Svensson, Otto Savolainen, Katty Terrazas Aranda, Kristina Eriksson
ETHNOPHARMACOLOGICAL RELEVANCE: Equisetum giganteum L and Copaifera reticulate Ducke have been traditionally used by women of the Tacana tribe in the Bolivian Amazonas for genital hygiene and for treatment of genital infection/inflammation. AIM OF THE STUDY: To assess the ability of extracts from Equisetum giganteum L and Copaifera reticulate Ducke to block genital viral infection by herpes simplex virus type 2. MATERIALS AND METHODS: Equisetum giganteum L and Copaifera reticulate Ducke were collected from the Amazon region of La Paz, Bolivia...
August 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28797967/multipurpose-tenofovir-disoproxil-fumarate-electrospun-fibers-for-the-prevention-of-hiv-1-and-hsv-2-infections-in-vitro
#20
Kevin M Tyo, Hung R Vuong, Danial A Malik, Lee B Sims, Houda Alatassi, Jinghua Duan, Walter H Watson, Jill M Steinbach-Rankins
Sexually transmitted infections affect hundreds of millions of people worldwide. Both human immunodeficiency virus (HIV-1 and -2) and herpes simplex virus-2 (HSV-2) remain incurable, urging the development of new prevention strategies. While current prophylactic technologies are dependent on strict user adherence to achieve efficacy, there is a dearth of delivery vehicles that provide discreet and convenient administration, combined with prolonged-delivery of active agents. To address these needs, we created electrospun fibers (EFs) comprised of FDA-approved polymers, poly(lactic-co-glycolic acid) (PLGA) and poly(DL-lactide-co-ε-caprolactone) (PLCL), to provide sustained-release and in vitro protection against HIV-1 and HSV-2...
August 7, 2017: International Journal of Pharmaceutics
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