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https://www.readbyqxmd.com/read/28440579/prevalence-of-herpes-simplex-virus-types-1-and-2-at-maternal-and-fetal-sides-of-the-placenta-in-asymptomatic-pregnant-women
#1
Fabiana Finger-Jardim, Emiliana C Avila, Vanusa P da Hora, Carla V Gonçalves, Ana Maria B de Martinez, Marcelo A Soares
PROBLEM: Herpes simplex virus 1 (HSV-1) commonly causes orolabial infection, but can also infect the genital mucosa. In contrast, HSV-2 is usually genital. Genital herpes can transmit the virus vertically to the fetus during pregnancy. We sought to estimate the prevalence of HSV-1/2 on the maternal and fetal sides of the placenta. METHOD OF STUDY: Placental tissues were collected from pregnant women seen at the Rio Grande University Hospital. HSV-1 and HSV-2 were detected by nested PCR...
April 25, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28418354/-clinical-and-morphological-signs-of-viral-damage-to-a-kidney-transplant
#2
S E Solovyeva, E M Paltseva, M M Morozova, M M Kaabak, N A Krainik, A V Matveev
AIM: Тo compare morphological changes and results of immunohistochemical (IHC) identification of viruses (polyomaviruses, adenoviruses, and herpesviruses) in the biopsy specimens with their clinical manifestations in recipients of renal transplants. MATERIAL AND METHODS: Morphological and IHC studies were conducted using 71 needle renal transplant biopsy specimens from patients in the study group and 10 renal biopsy specimens from those in the control group. A number of clinical indicators were estimated...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28417331/use-of-high-dose-oral-valacyclovir-during-an-intravenous-acyclovir-shortage-a-retrospective-analysis-of-tolerability-and-drug-shortage-management
#3
Milena M McLaughlin, Sarah H Sutton, Ashley O Jensen, John S Esterly
INTRODUCTION: In late 2011, a shortage of IV acyclovir led to the need to empirically substitute high-dose oral valacyclovir (HDVA) to conserve IV acyclovir for patients with confirmed herpes simplex virus (HSV) meningitis or encephalitis. This report describes the management of the most recent national IV acyclovir shortage by the Antimicrobial Stewardship Program (ASP) at Northwestern Memorial Hospital (NMH), Chicago, IL, USA, and the use of HDVA. Secondarily, we assessed the safety and tolerability of HDVA as an alternate to IV acyclovir during this shortage...
April 17, 2017: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/28413399/hsv-1-hsv-2-infection-related-cancers-in-bantu-populations-driving-hiv-1-prevalence-in-africa-tracking-the-origin-of-aids-at-the-onset-of-the-20th-century
#4
Jacqueline Le Goaster, Patrice Bouree, Franck N El Sissy, Florence Phuong Bui, Johanna Pokossy Epee, Paul Rollin, Frédéric Tangy, Anne-Lise Haenni
INTRODUCTION: At the onset of the 20th century, ancient clinical observations of cancer epidemics in Bantu populations of Sub-Saharan Africa were discovered. They were reported from 1914 to 1960, but remained unexplained. In 1983, in San Francisco, Calif., USA, cancer epidemics were related to infections by the human immunodeficiency virus type 1 (HIV-1) known as AIDS disease. Yet since 1996, it is known that HIV-1 strains are not the only ones involved. In Sub-Saharan Africa, recurrent orobuccal herpes simplex virus type 1 (HSV-1) and genital recurrent herpes simplex virus type 2 (HSV-2) appeared many times prior to infection by HIV-1...
September 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/28406272/dorsal-longitudinal-foreskin-cut-is-associated-with-reduced-risk-of-hiv-syphilis-and-genital-herpes-in-men-a-cross-sectional-study-in-papua-new-guinea
#5
Andrew J Vallely, David MacLaren, Matthew David, Pamela Toliman, Angela Kelly-Hanku, Ben Toto, Rachael Tommbe, Zure Kombati, Petronia Kaima, Kelwyn Browne, Clement Manineng, Lalen Simeon, Claire Ryan, Handan Wand, Peter Hill, Greg Law, Peter M Siba, W John H McBride, John M Kaldor
INTRODUCTION: Various forms of penile foreskin cutting are practised in Papua New Guinea. In the context of an ecological association observed between HIV infection and the dorsal longitudinal foreskin cut, we undertook an investigation of this relationship at the individual level. METHODS: We conducted a cross-sectional study among men attending voluntary confidential HIV counselling and testing clinics. Following informed consent, participants had a face-to-face interview and an examination to categorize foreskin status...
April 3, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28405631/electric-cell-substrate-impedance-sensing-to-monitor-viral-growth-and-study-cellular-responses-to-infection-with-alphaherpesviruses-in-real-time
#6
Matthew R Pennington, Gerlinde R Van de Walle
Electric cell-substrate impedance sensing (ECIS) measures changes in an electrical circuit formed in a culture dish. As cells grow over a gold electrode, they block the flow of electricity and this is read as an increase in electrical impedance in the circuit. ECIS has previously been used in a variety of applications to study cell growth, migration, and behavior in response to stimuli in real time and without the need for cellular labels. Here, we demonstrate that ECIS is also a valuable tool with which to study infection by alphaherpesviruses...
March 2017: MSphere
https://www.readbyqxmd.com/read/28404850/stress-hormones-epinephrine-and-corticosterone-selectively-modulate-hsv-1-and-hsv-2-productive-infection-in-adult-sympathetic-but-not-sensory-neurons
#7
Angela M Ives, Andrea S Bertke
Herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) infect and establish latency in peripheral neurons, from which they can reactivate to cause recurrent disease throughout the life of the host. Stress is associated with exacerbation of clinical symptoms and induction of recurrences in humans and animal models. The viruses preferentially replicate and establish latency in different subtypes of sensory neurons, as well as in neurons of the autonomic nervous system that are highly responsive to stress hormones. To determine if stress-related hormones modulate productive HSV-1 and HSV-2 infection within sensory and autonomic neurons, we analyzed viral DNA and production of viral progeny after treatment of primary adult murine neuronal cultures with the stress hormones epinephrine and corticosterone...
April 12, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28396556/pregnancy-outcomes-in-association-with-stds-including-genital-hsv-2-shedding-in-a-south-african-cohort-study
#8
Dhayendre Moodley, Benn Sartorius, Savithree Madurai, Vani Chetty, Suzanne Maman
OBJECTIVES: Genital herpes simplex virus-2 (HSV-2) shedding in pregnant women in association with neonatal herpes infection has been widely studied but there is limited evidence of its association with pregnancy outcomes. METHODS: In this retrospective observational study, we included a subgroup of pregnant women who were enrolled in a randomized control behavioural intervention study that was conducted in South Africa in 2008-2010. In pregnancy, women had a HIV rapid test done and a genital swab taken to test for curable STIs and HSV-2 DNA...
April 10, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28392553/effectiveness-of-early-antiviral-therapy-in-disseminated-neonatal-herpes-simplex-virus-2-hsv-2-with-fulminant-hepatic-failure
#9
Divya Mirchandani, Rafia Jawed, Nayaab Khawar, Pramod Narula, Minnie John
BACKGROUND Liver failure in the neonatal population is a life-threatening complication and has a wide array of etiologies, including infectious, immune-mediated, metabolic, or drug-induced. Although neonatal herpes simplex virus (HSV) hepatitis only accounts for 1% of all acute liver failures, it has an extremely aggressive clinical course that carries a mortality rate of 85%. CASE REPORT We report a rare case of disseminated neonatal HSV-2 with late presentation associated with fulminant liver failure. The patient recovered without obvious neurologic deficits or need for liver transplant...
April 10, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28378925/evaluation-of-recombinant-adenovirus-vaccines-based-on-glycoprotein-d-and-truncated-ul25-against-herpes-simplex-virus-type-2-in-mice
#10
Wei Liu, Yan Zhou, Ziyan Wang, Zeqiang Zhang, Qizhi Wang, Weiheng Su, Yan Chen, Yan Zhang, Feng Gao, Chunlai Jiang, Wei Kong
The high prevalence of herpes simplex virus 2 (HSV-2) infections in humans necessitates the development of a safe and effective vaccine that will need to induce vigorous T-cell responses to control the viral infection and transmission. We designed rAd-gD2rAd-gD2▵UL25rAd-▵UL25 to investigate whether recombinant replication-defective adenoviruses vaccine could induce specific T cell responses and protect mice against intravaginal HSV-2 challenge compared with FI-HSV-2. The recombinant adenovirus-based HSV-2 showed higher reductions in mortality and stronger antigen-specific T cell responses compared with FI-HSV-2 and the severity of genital lesions in the mice immunized with rAd-gD2▵UL25 was significantly decreased via eliciting IFN-γ-secreting T responses compared with rAd-gD2 and rAd-▵UL25 group in present study...
April 5, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/28376707/atypical-herpetic-whitlow-a-diagnosis-to-consider
#11
Caterina Foti, Paolo Romita, Paolo Mascia, Agata Calvario
Herpetic whitlow is caused by herpes virus (type1 or 2) during primary infection or as result of autoinoculation. Commonly, it is caused by HSV-2 in adults with positive history for genital infection. We report a rare case of herpetic whitlow that should be kept in mind by physicians in recurrent cases of fingers infection. Advanced diagnostic techniques as PCR are required to help clinicians to achieve a definite diagnosis and to choose the right treatment.
March 31, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28373917/leflunomide-in-the-treatment-of-a-pseudotumoral-genital-herpes-simplex-virus-infection-in-an-hiv-patient
#12
Marie R Roger, Gregory M Anstead
The patient is a 52-year-old African American man with a past medical history of HIV infection (on antiretroviral therapy, CD4 count 399 cells/µL, and undetectable HIV viral load) and recurrent genital herpes. While on valacyclovir, the patient presented with four tumorous lesions on the perineum and scrotum. A biopsy specimen stained positively with HSV-1 and HSV-2 immunostains and displayed a lymphoplasmacytic infiltrate. The patient received foscarnet and imiquimod for two weeks with minimal improvement...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28370198/diclofenac-based-hydrazones-and-spirothiazolidinones-synthesis-characterization-and-antimicrobial-properties
#13
Ayşe Kocabalkanlı, Gökçe Cihan-Üstündağ, Lieve Naesens, Emel Mataracı-Kara, Mebble Nassozi, Gültaze Çapan
We report here the synthesis, structural characterization, and biological evaluation of novel diclofenac-based hydrazone (4a-f) and spirothiazolidinone (5a-f, 6a-f) derivatives designed as potential antimicrobial agents. The compounds were evaluated in vitro for their antiviral activity against a wide spectrum of DNA and RNA viruses. They were further screened in vitro against different strains of bacteria and fungi. The hydrazone derivatives, 4a and 4c-f, were found to be active against herpesviruses (HSV-1, HSV-2, and HSV-1 TK(-) ), vaccinia virus, and Coxsackie B4 virus, with EC50 values between 6...
March 30, 2017: Archiv der Pharmazie
https://www.readbyqxmd.com/read/28369565/ancient-recombination-events-between-human-herpes-simplex-viruses
#14
Sonia Burrel, David Boutolleau, Diane Ryu, Henri Agut, Kevin Merkel, Fabian H Leendertz, Sébastien Calvignac-Spencer
Herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) are seen as close relatives but also unambiguously considered as evolutionary independent units. Here, we sequenced the genomes of 18 HSV-2 isolates characterized by divergent UL30 gene sequences to further elucidate the evolutionary history of this virus. Surprisingly, genome-wide recombination analyses showed that all HSV-2 genomes sequenced to date contain HSV-1 fragments. Using phylogenomic analyses, we could also show that two main HSV-2 lineages exist. One lineage is mostly restricted to sub-Saharan Africa while the other has reached a global distribution...
March 28, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28358704/prevalence-of-neurotropic-viruses-in-malignant-glioma-and-their-onco-modulatory-potential
#15
Tadej Strojnik, Darja Duh, Tamara T Lah
BACKGROUND: the association between infectious agents and tumour aetiology is relevant in about 20% of cases. PATIENTS AND METHODS: We tested high-grade glioma tissues from 45 patients for the presence of viral nucleic acids of six herpes viruses, human adenoviruses (A-G), and two neurotropic human viruses (enteroviruses, tick-borne encephalitis virus). Real-time polymerase chain reaction was used with immunolabelling. RESULTS: Three species of herpes viruses were detected: HSV-2, Epstein-Barr virus (EBV), HHV-6, and one human enterovirus...
March 2017: In Vivo
https://www.readbyqxmd.com/read/28357380/genital-herpes-insights-into-sexually-transmitted-infectious-disease
#16
REVIEW
Dinesh Jaishankar, Deepak Shukla
Etiology, transmission and protection: Herpes simplex virus-2 (HSV-2) is a leading cause of sexually transmitted infections with recurring manifestations throughout the lifetime of infected hosts. Currently no effective vaccines or prophylactics exist that provide complete protection or immunity from the virus, which is endemic throughout the world. Pathology/Symptomatology: Primary and recurrent infections result in lesions and inflammation around the genital area and the latter accounts for majority of genital herpes instances...
June 27, 2016: Microbial Cell
https://www.readbyqxmd.com/read/28333902/proteflazid%C3%A2-and-local-immunity-in-diseases-caused-by-human-papillomavirus-herpesvirus-and-mixed-urogenital-infections
#17
Vjacheslav Kaminsky, Viktor Chernyshov, Oleksandr Grynevych, Vasil Benyuk, Alla Kornatskaya, Miroslava Shalko, Igor Usevich, Oleg Revenko, Maxim Shepetko, Ludmila Solomakha
Reporting of clinical trials results for Proteflazid® in the drug formulation suppositories and vaginal swabs soaked in the solution of the drug to the local immunity of the female reproductive tract. AIM: The aim of study was to examine the state of local immunity in the reproductive tract of women with sexually transmitted diseases caused by human papillomavirus, herpes viruses (Type 1, 2) and mixed infection (herpes viruses + chlamydia). MATERIALS AND METHODS: The trials involved 216 women with viral sexually transmitted diseases: Cervical Dysplasia associated with papillomavirus infection (HPV) (Group 1); Herpes genitalis type 1 (HSV- 1) and type 2 (HSV-1) (Group 2); mixed infection - HSV-1, HSV-2 and chlamydia (Group 3)...
March 21, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28332725/comparison-of-commercial-methods-of-immunoblot-elisa-and%C3%A2-chemiluminescent-immunoassay-for-detecting-type-specific-herpes-simplex-viruses-1-and-2-igg
#18
Fernando de Ory, María-Eulalia Guisasola, Pilar Balfagón, Juan Carlos Sanz
BACKGROUND: Serology for type-specific herpes simplex virus (HSV) is based on the use of the respective glycoprotein G (gG). METHODS: Chemiluminescent immunoassay (CLIA; BIO-FLASH(®) , Biokit, Spain), ELISA (HerpeSelect(®) , Focus, USA), and immunoblot (IB; Virotech, Germany) for detecting HSV-1- and HSV-2-specific IgG were compared using 384 serum samples received for HSV serology. The samples were classified as positive or negative according to a consensus criterion...
March 23, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28329739/peptides-derived-from-glycoproteins-h-and-b-of-herpes-simplex-virus-type-1-and-herpes-simplex-virus-type-2-are-capable-of-blocking-herpetic-infection-in-vitro
#19
Abraham Cetina-Corona, Uriel López-Sánchez, Juana Salinas-Trujano, Alfonso Méndez-Tenorio, Blanca Lilia Barrón, Jesus Torres-Flores
AIMS: The aim of this study was to design peptides derived from glycoproteins H (gH) and B (gB) of herpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2) with the potential to block herpetic infection and to evaluate their ability to inhibit HSV-1 and HSV-2 infection in vitro. METHODS: A library of continuous 15-25 residue stretches (CRSs) located at the surface of gH and gB from HSV-1 and HSV-2 was created. These CRSs were analyzed, and only those that were highly flexible and rich in charged residues were selected for the design of the antiviral peptides (AVPs)...
March 23, 2017: Intervirology
https://www.readbyqxmd.com/read/28329667/serious-infections-are-on-the-rise-in-us-inpatients-with-psoriasis
#20
Derek Y Hsu
Psoriasis is a chronic inflammatory skin disorder associated with immune dysregulation and use of systemic immunosuppressive treatments that may predispose toward serious infections. We sought to determine the rates of serious infections in hospitalized patients with psoriasis. We analyzed data from the 2002-2012 Nationwide Inpatient Sample, containing a 20% sample of all US hospitalizations. Psoriasis was determined by a validated algorithm using ICD-9-CM codes. In multivariate logistic regression models adjusting for socio-demographics, psoriasis was associated with multiple serious infections, including methicillin-resistant Staphylococcus aureus (odds ratio [95% confidence intervals] 1...
September 15, 2016: Dermatology Online Journal
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