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https://www.readbyqxmd.com/read/28520594/amplivue-is-a-practical-and-timely-test-for-the-detection-of-hsv-from-keratitis-specimens
#1
Regis P Kowalski, Lisa M Karenchak, Deepinder K Dhaliwal, Alex Mammen
OBJECTIVE: The laboratory diagnostic detection of herpes simplex virus (HSV) from eye samples must be practical, timely, and definitive for appropriate therapy. Although polymerase chain reaction (PCR) and/or cell culture can be definitive, HSV results can be delayed. Enzyme Linked Virus Inducible System (ELVIS) is a test that can provide results within 24 to 48 hr. We evaluated "AmpliVue HSV 1+2 Assay" as a molecular colorimetric test that can detect HSV (1 or 2) DNA within 1 hr. METHODS: Cornea/conjunctival samples were tested retrospectively with AmpliVue against 53 true-positive and 20 true-negative specimens collected in chlamydial transport medium...
May 16, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28520494/racial-ethnic-disparities-at-the-end-of-an-hiv-epidemic-persons-who-inject-drugs-in-new-york-city-2011-2015
#2
Don C Des Jarlais, Kamyar Arasteh, Courtney McKnight, Jonathan Feelemyer, Susan Tross, David Perlman, Samuel Friedman, Aimee Campbell
OBJECTIVES: To examine whether racial/ethnic disparities persist at the "end of the HIV epidemic" (prevalence of untreated HIV infection < 5%; HIV incidence < 0.5 per 100 person-years) among persons who inject drugs (PWID) in New York City. METHODS: We recruited 2404 PWID entering New York City substance use treatment in 2001 to 2005 and 2011 to 2015. We conducted a structured interview, and testing for HIV and herpes simplex virus 2 (HSV-2; a biomarker for high sexual risk)...
May 18, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28515628/epidemiology-of-herpes-simplex-virus-type-1-and-2-in-italy-a-seroprevalence-study-from-2000-to-2014
#3
REVIEW
S Marchi, C M Trombetta, R Gasparini, N Temperton, E Montomoli
Herpes simplex viruses (HSV) are among the most widespread causative agents of human viral infections. HSV-2 is one of the commonest causes of genital disease, while HSV-1 is associated primarily with orolabial ulceration; however, recent changes in HSV epidemiology showed an increase in genital and neonatal herpes particularly caused by HSV-1. The main purpose of this study was to assess the seroprevalence of HSV-1 and HSV-2 in a random population in Siena (central Italy) in 2000, 2005 and 2013-2014 and in Bari (southern Italy) in 2005...
March 2017: Journal of Preventive Medicine and Hygiene
https://www.readbyqxmd.com/read/28514276/sexual-network-drivers-of-hiv-and-herpes-simplex-virus-type-2-hsv-2-transmission-a-comparative-mathematical-modeling-analysis
#4
Ryosuke Omori, Laith J Abu-Raddad
OBJECTIVES: HIV and herpes simplex virus type 2 (HSV-2) infections are sexually transmitted and propagate in sexual networks. Using mathematical modeling, we aimed to quantify effects of key network statistics on infection transmission, and extent to which HSV-2 prevalence can be a proxy of HIV prevalence. DESIGN/METHODS: An individual-based simulation model was constructed to describe sex partnering and infection transmission, and was parameterized with representative natural history, transmission, and sexual behavior data...
May 16, 2017: AIDS
https://www.readbyqxmd.com/read/28508238/surgical-excision-for-recurrent-herpes-simplex-virus-2-hsv-2-anogenital-infection-in-a-patient-with-human-immunodeficiency-virus-hiv
#5
Folasade Arinze, Aaron Shaver, Stephen Raffanti
Recurrent anogenital herpes simplex virus infections are common in patients with human immunodeficiency virus (HIV), of whom approximately 5% develop resistance to acyclovir. We present a case of a 49-year-old man with HIV who had an 8-year history of recurrent left inguinal herpes simplex virus type 2 ulcerations. He initially responded to oral acyclovir, but developed resistance to acyclovir and eventually foscarnet. The lesion progressed to a large hypertrophic mass that required surgical excision, which led to resolution without recurrences...
May 15, 2017: Infection
https://www.readbyqxmd.com/read/28507315/the-herpesvirus-nuclear-egress-complex-component-ul31-can-be-recruited-to-sites-of-dna-damage-through-poly-adp-ribose-binding
#6
Maxwell R Sherry, Thomas J M Hay, Michael A Gulak, Arash Nassiri, Renée L Finnen, Bruce W Banfield
The herpes simplex virus (HSV) UL31 gene encodes a conserved member of the herpesvirus nuclear egress complex that not only functions in the egress of DNA containing capsids from the nucleus, but is also required for optimal replication of viral DNA and its packaging into capsids. Here we report that the UL31 protein from HSV-2 can be recruited to sites of DNA damage by sequences found in its N-terminus. The N-terminus of UL31 contains sequences resembling a poly (ADP-ribose) (PAR) binding motif suggesting that PAR interactions might mediate UL31 recruitment to damaged DNA...
May 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28493891/antibody-to-hsv-gd-peptide-induced-by-vaccination-does-not-protect-against-hsv-2-infection-in-hsv-2-seronegative-women
#7
Peter B Gilbert, Jean-Louis Excler, Georgia D Tomaras, Lindsay N Carpp, Barton F Haynes, Hua-Xin Liao, David C Montefiori, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Jaranit Kaewkungwal, Gustavo H Kijak, Sodsai Tovanabutra, Donald P Francis, Carter Lee, Faruk Sinangil, Phillip W Berman, Nakorn Premsri, Prayura Kunasol, Robert J O'Connell, Nelson L Michael, Merlin L Robb, Rhoda Morrow, Lawrence Corey, Jerome H Kim
BACKGROUND: In the HIV-1 vaccine trial RV144, ALVAC-HIV prime with an AIDSVAX® B/E boost reduced HIV-1 acquisition by 31% at 42 months post first vaccination. The bivalent AIDSVAX® B/E vaccine contains two gp120 envelope glycoproteins, one from the subtype B HIV-1 MN isolate and one from the subtype CRF01_AE A244 isolate. Each envelope glycoprotein harbors a highly conserved 27-amino acid HSV-1 glycoprotein D (gD) tag sequence that shares 93% sequence identity with the HSV-2 gD sequence...
2017: PloS One
https://www.readbyqxmd.com/read/28490581/patterns-of-prevalent-hpv-and-sti-co-infections-and-associated-factors-among-hiv-negative-young-western-cape-south-african-women-the-evri-trial
#8
Lynette J Menezes, Ubin Pokharel, Staci L Sudenga, Matthys H Botha, Michele Zeier, Martha E Abrahamsen, Richard H Glashoff, Susan Engelbrecht, Maarten F Schim van der Loeff, Louvina E van der Laan, Siegfried Kipping, Douglas Taylor, Anna R Giuliano
OBJECTIVE: To estimate the prevalence and describe the patterns of concurrent human papillomavirus (HPV) and STIs and associated factors among HIV-negative young Western Cape, South African women participating in the Efficacy of HPV Vaccine to Reduce HIV Infection (EVRI) trial. METHODS: HIV-negative women aged 16-24 years old were enrolled in the EVRI trial (NCT01489527) and randomised to receive the licensed four-valent HPV vaccine or placebo. At study entry, participants were clinically evaluated for five STIs: herpes simplex virus type 2 (HSV-2), chlamydia, gonorrhoea, syphilis and disease-causing HPV genotypes (6/11/16/18/31/33/35/39/45/51/52/56/58/59/68)...
May 10, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28481687/a-trivalent-subunit-antigen-glycoprotein-vaccine-as-immunotherapy-for-genital-herpes-in-the-guinea-pig-genital-infection-model
#9
Sita Awasthi, Lauren M Hook, Carolyn E Shaw, Harvey M Friedman
An estimated 417 million people worldwide ages 15 to 49 are infected with herpes simplex virus type 2 (HSV-2), the most common cause of genital ulcer disease. Some individuals experience frequent recurrences of genital lesions, while others only have subclinical infection, yet all risk transmitting infection to their intimate partners. A vaccine was developed that prevents shingles, which is a recurrent infection caused by varicella-zoster virus (VZV), a closely related member of the Herpesviridae family. The success of the VZV vaccine has stimulated renewed interest in a therapeutic vaccine for genital herpes...
May 8, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28476154/cluster-randomized-evaluation-of-adolescent-girls-empowerment-programme-agep-study-protocol
#10
Paul C Hewett, Karen Austrian, Erica Soler-Hampejsek, Jere R Behrman, Fiammetta Bozzani, Natalie A Jackson-Hachonda
BACKGROUND: Adolescents in less developed countries such as Zambia often face multi-faceted challenges for achieving successful transitions through adolescence to early adulthood. The literature has noted the need to introduce interventions during this period, particularly for adolescent girls, with the perspective that such investments have significant economic, social and health returns to society. The Adolescent Girls Empowerment Programme (AGEP) was an intervention designed as a catalyst for change for adolescent girls through themselves, to their family and community...
May 5, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28471862/t-cell-responses-to-hsv-1-in-persons-who-have-survived-childhood-herpes-simplex-encephalitis
#11
Mariliis Ott, Lichen Jing, Lazaro Lorenzo, Jean-Laurent Casanova, Shen-Ying Zhang, David M Koelle
BACKGROUND: Herpes simplex encephalitis (HSE) after primary HSV-1 infection can occur in children due to inborn errors of cell-intrinsic immunity in the central nervous system (CNS). Paradoxically, symptomatic mucocutaneous HSV-1 recurrences are rare survivors of childhood HSE. T-cell acquired immunity is thought to be involved in control of recurrent mucocutaneous HSV infection. We thus tested HSV-1-specific immunity in HSE survivors. METHODS: We obtained serum and peripheral blood mononuclear cells (PBMC) a median of 13...
May 3, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28468298/hibiscus-sabdariffa-l-and-its-bioactive-constituents-exhibit-antiviral-activity-against-hsv-2-and-anti-enzymatic-properties-against-urease-by-an-esi-ms-based-assay
#12
Sherif T S Hassan, Emil Švajdlenka, Kateřina Berchová-Bímová
For decades, Hibiscus sabdariffa L. and its phytochemicals have been shown to possess a wide range of pharmacologic properties. In this study, aqueous extract of Hibiscus sabdariffa (AEHS) and its bioactive constituent protocatechuic acid (PCA), have been evaluated in vitro for their antiviral activity against HSV-2 clinical isolates and anti-enzymatic activity against urease. Antiherpetic activity was evaluated by the titer reduction assay in infected Vero cells, and cytotoxicity was evaluated by the neutral red dye-uptake method...
April 30, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28458823/herpes-simplex-virus-type-1-encephalitis-in-an-adolescent-presenting-with-acute-hydrocephalus
#13
Marios S Themistocleous, Elias Antoniades, Dimitrios Giakoumettis, Aristoteles V Kalyvas, Andreas Mitsios, George Sfakianos
Herpes simplex virus Type 1 (HSV-1) is a human neurotropic virus causing encephalitis, corneal blindness or several peripheral nervous system disorders. Herpes Simplex encephalitis (HSE) is the most devastating clinical syndrome with severe morbidity and mortality. Hydrocephalus associated with viral meningoencephalitis is an extremely rare entity with only few documented cases, predominantly due to HSV-2 infection. HSV-1 infection of central nervous system present in the majority of the cases as encephalitis...
February 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28453835/herpes-simplex-virus-type-2-acquisition-among-hiv-1-infected-adults-treated-with-tenofovir-disoproxyl-fumarate-as-part-of-combination-antiretroviral-therapy-results-from-the-actg-a5175-pearls-study
#14
Connie Celum, Ting Hong, Anne Cent, Deborah Donnell, Rhoda Morrow, Jared M Baeten, Cynthia Firnhaber, Beatriz Grinsztejn, Mina C Hosseinipour, Umesh Lalloo, Mulinda Nyirenda, Cynthia Riviere, Jorge Sanchez, Breno Santos, Khuanchai Supparatpinyo, James Hakim, N Kumarasamy, Thomas B Campbell
Objective.: Tenofovir disoproxyl fumarate (TDF) disoproxyl fumarate (TDF) has in vitro activity against herpes simplex virus type 2 (HSV-2) and reduced HSV-2 acquisition as preexposure prophylaxis. Whether TDF-containing antiretroviral therapy (ART) reduces HSV-2 acquisition is unknown. Design.: Secondary analysis of AIDS Clinical Trials Group A5175, a randomized, open-label study of 3 ART regimens among 1571 participants. Methods.: HSV-2 serostatus was assessed at baseline, at study exit, and before a change in ART regimen...
March 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28448558/the-herpevac-trial-for-women-sequence-analysis-of-glycoproteins-from-viruses-obtained-from-infected-subjects
#15
Miguel A Minaya, Maria Korom, Hong Wang, Robert B Belshe, Lynda A Morrison
The Herpevac Trial for Women revealed that three dose HSV-2 gD vaccine was 58% protective against culture-positive HSV-1 genital disease, but it was not protective against HSV-2 infection or disease. To determine whether vaccine-induced immune responses had selected for a particular gD sequence in strains infecting vaccine recipients compared with viruses infecting control subjects, genetic sequencing studies were carried out on viruses isolated from subjects infected with HSV-1 or HSV-2. We identified naturally occurring variants among the gD sequences obtained from 83 infected subjects...
2017: PloS One
https://www.readbyqxmd.com/read/28443092/disarming-cellular-alarm-systems-manipulation-of-stress-induced-nkg2d-ligands-by-human-herpesviruses
#16
REVIEW
Dominik Schmiedel, Ofer Mandelboim
The coevolution of viruses and their hosts led to the repeated emergence of cellular alert signals and viral strategies to counteract them. The herpesvirus family of viruses displays the most sophisticated repertoire of immune escape mechanisms enabling infected cells to evade immune recognition and thereby maintain infection. The herpesvirus family consists of nine viruses that are capable of infecting humans: herpes simplex virus 1 and 2 (HSV-1, HSV-2), varicella zoster virus (VZV), Epstein-Barr virus (EBV), human cytomegalovirus (HCMV), roseoloviruses (HHV-6A, HHV-6B, and HHV-7), and Kaposi's-sarcoma-associated herpesvirus (KSHV)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28440579/prevalence-of-herpes-simplex-virus-types-1-and-2-at-maternal-and-fetal-sides-of-the-placenta-in-asymptomatic-pregnant-women
#17
Fabiana Finger-Jardim, Emiliana C Avila, Vanusa P da Hora, Carla V Gonçalves, Ana Maria B de Martinez, Marcelo A Soares
PROBLEM: Herpes simplex virus 1 (HSV-1) commonly causes orolabial infection, but can also infect the genital mucosa. In contrast, HSV-2 is usually genital. Genital herpes can transmit the virus vertically to the fetus during pregnancy. We sought to estimate the prevalence of HSV-1/2 on the maternal and fetal sides of the placenta. METHOD OF STUDY: Placental tissues were collected from pregnant women seen at the Rio Grande University Hospital. HSV-1 and HSV-2 were detected by nested PCR...
April 25, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28418354/-clinical-and-morphological-signs-of-viral-damage-to-a-kidney-transplant
#18
S E Solovyeva, E M Paltseva, M M Morozova, M M Kaabak, N A Krainik, A V Matveev
AIM: Тo compare morphological changes and results of immunohistochemical (IHC) identification of viruses (polyomaviruses, adenoviruses, and herpesviruses) in the biopsy specimens with their clinical manifestations in recipients of renal transplants. MATERIAL AND METHODS: Morphological and IHC studies were conducted using 71 needle renal transplant biopsy specimens from patients in the study group and 10 renal biopsy specimens from those in the control group. A number of clinical indicators were estimated...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28417331/use-of-high-dose-oral-valacyclovir-during-an-intravenous-acyclovir-shortage-a-retrospective-analysis-of-tolerability-and-drug-shortage-management
#19
Milena M McLaughlin, Sarah H Sutton, Ashley O Jensen, John S Esterly
INTRODUCTION: In late 2011, a shortage of IV acyclovir led to the need to empirically substitute high-dose oral valacyclovir (HDVA) to conserve IV acyclovir for patients with confirmed herpes simplex virus (HSV) meningitis or encephalitis. This report describes the management of the most recent national IV acyclovir shortage by the Antimicrobial Stewardship Program (ASP) at Northwestern Memorial Hospital (NMH), Chicago, IL, USA, and the use of HDVA. Secondarily, we assessed the safety and tolerability of HDVA as an alternate to IV acyclovir during this shortage...
April 17, 2017: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/28413399/hsv-1-hsv-2-infection-related-cancers-in-bantu-populations-driving-hiv-1-prevalence-in-africa-tracking-the-origin-of-aids-at-the-onset-of-the-20th-century
#20
Jacqueline Le Goaster, Patrice Bouree, Franck N El Sissy, Florence Phuong Bui, Johanna Pokossy Epee, Paul Rollin, Frédéric Tangy, Anne-Lise Haenni
INTRODUCTION: At the onset of the 20th century, ancient clinical observations of cancer epidemics in Bantu populations of Sub-Saharan Africa were discovered. They were reported from 1914 to 1960, but remained unexplained. In 1983, in San Francisco, Calif., USA, cancer epidemics were related to infections by the human immunodeficiency virus type 1 (HIV-1) known as AIDS disease. Yet since 1996, it is known that HIV-1 strains are not the only ones involved. In Sub-Saharan Africa, recurrent orobuccal herpes simplex virus type 1 (HSV-1) and genital recurrent herpes simplex virus type 2 (HSV-2) appeared many times prior to infection by HIV-1...
September 2016: Case Reports in Oncology
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