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https://www.readbyqxmd.com/read/28320026/-alcohol-withdrawal-and-its-major-complications
#1
Klaus Junghanns, Tilman Wetterling
Delirium tremens is one of the most common complications of alcohol withdrawal. It is potentially lethal and therefore should be detected as early as possible and be monitored and treated intensively. The assessment of risk factors with the Luebeck Alcohol-Withdrawal Risk Scale short form (LARS-11) can help to predict the risk of severe withdrawal adequately. As delirium cannot be differentiated from Wernicke-Encephalopathy with sufficient certainty high parenteral doses of Vitamin B1 and Magnesium orally should be given in case of any severe withdrawal symptoms...
March 2017: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/28319902/ultra-high-sensitivity-of-the-non-immunological-affinity-of-graphene-oxide-peptide-based-surface-plasmon-resonance-biosensors-to-detect-human-chorionic-gonadotropin
#2
Nan-Fu Chiu, Chia-Tzu Kuo, Ting-Li Lin, Chia-Chen Chang, Chen-Yu Chen
Specific peptide aptamers can be used in place of expensive antibody proteins, and they are gaining increasing importance as sensing probes due to their potential in the development of non-immunological assays with high sensitivity, affinity and specificity for human chorionic gonadotropin (hCG) protein. We combined graphene oxide (GO) sheets with a specific peptide aptamer to create a novel, simple and label-free tool to detect abnormalities at an early stage of pregnancy, a GO-peptide-based surface plasmon resonance (SPR) biosensor...
March 7, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28319713/observational-evidence-on-the-effects-of-mega-fires-on-the-frequency-of-hydrogeomorphic-hazards-the-case-of-the-peloponnese-fires-of-2007-in-greece
#3
M Diakakis, E I Nikolopoulos, S Mavroulis, E Vassilakis, E Korakaki
Even though rare, mega-fires raging during very dry and windy conditions, record catastrophic impacts on infrastructure, the environment and human life, as well as extremely high suppression and rehabilitation costs. Apart from the direct consequences, mega-fires induce long-term effects in the geomorphological and hydrological processes, influencing environmental factors that in turn can affect the occurrence of other natural hazards, such as floods and mass movement phenomena. This work focuses on the forest fire of 2007 in Peloponnese, Greece that to date corresponds to the largest fire in the country's record that burnt 1773km(2), causing 78 fatalities and very significant damages in property and infrastructure...
March 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28319663/2h-ws2-quantum-dots-produced-by-modulating-the-dimension-and-phase-of-1t-nanosheets-for-antibody-free-optical-sensing-of-neurotransmitters
#4
Man-Jin Kim, Su-Ji Jeon, Tae Woog Kang, Jong-Min Ju, DaBin Yim, Hye-In Kim, Jung Hyun Park, Jong-Ho Kim
Modulating the dimensions and phases of transition metal dichalcogenides is of great interest to enhance their intrinsic properties or to create new physicochemical properties. Herein, we report an effective approach to synthesize 2H-WS2 quantum dots (QDs) via the dimension and phase engineering of 1T-WS2 nanosheets. The solvothermal reaction of chemically-exfoliated 1T-WS2 nanosheets in N-methyl-2-pyrrolidone (NMP) under an N2 atmosphere induced their chopping and phase transition at lower temperature to produce 2H-WS2 QDs with a high quantum yield (5...
March 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28319655/meeting-nutritional-needs-in-the-first-1000-days-a-place-for-small-quantity-lipid-based-nutrient-supplements
#5
Seth Adu-Afarwuah, Anna Lartey, Kathryn G Dewey
The first 1000 days of life is marked by intense metabolic activity and tissue deposition. The increased nutritional needs during this period, and the challenges to meeting them, are often not understood or appreciated. Here, we describe the nutritional needs during the first 1000 days, highlight the challenges to meeting these needs in developing countries, outline intervention strategies, and examine the consumption of small-quantity lipid-based nutrient supplements (SQ-LNS) as a promising strategy. In low-income settings, the challenge to meeting nutritional needs during the first 1000 days is worsened by overreliance on cereal-based diets of low nutrient density and high prevalence of infections and infestations...
March 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28319589/exercise-improves-v-combining-dot-above-o-2max-and-body-composition-in-adt-treated-prostate-cancer-patients
#6
Bradley A Wall, Daniel A Galvão, Naeem Fatehee, Dennis R Taaffe, Nigel Spry, David Joseph, Jeffrey J Hebert, Robert U Newton
INTRODUCTION: Prostate cancer is the most common cancer in men and patients treated with androgen deprivation therapy (ADT) experience unfavourbale changes in body composition and associated metabolic complications, which can increase the risk of cardiovascular disease. We examined the effect of a 6-month program of aerobic and resistance exercise aimed at improving body composition and cardiorespiratory health in this population. METHODS: Ninety-seven men (43-90 years) with localized prostate cancer receiving ADT were randomized to either exercise (EX, n=50) or usual care (CON, n=47)...
March 18, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28319586/short-term-exercise-training-alters-leukocyte-chemokine-receptors-in-obese-adults
#7
Julianne C Barry, Svetlana Simtchouk, Cody Durrer, Mary E Jung, Jonathan P Little
Obesity is characterized by chronic low-grade inflammation driven by activation and tissue infiltration of circulating leukocytes. Although exercise has anti-inflammatory effects, the impact of exercise on mediators of leukocyte migration is unclear. PURPOSE: To determine the impact of high intensity interval training (HIIT) versus moderate intensity continuous training (MICT), in the absence of weight/fat loss, on circulating chemokines and leukocyte chemokine receptors. METHODS: Thirty-seven inactive obese adults were randomized to two weeks (10 sessions) of HIIT or MICT with fasting blood samples collected before and after training...
March 18, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28319509/a-high-preoperative-pain-and-symptom-profile-predicts-worse-pain-outcomes-for-children-after-spine-fusion-surgery
#8
Terri Voepel-Lewis, Michelle S Caird, Alan R Tait, Shobha Malviya, Frances A Farley, Ying Li, Matthew D Abbott, Tara van Veen, Afton L Hassett, Daniel J Clauw
BACKGROUND: Preoperative pain predicts persistent pain after spine fusion, yet little is understood about the nature of that pain, related symptoms, and how these symptoms relate to postoperative pain outcomes. This prospective study examined children's baseline pain and symptom profiles and the association between a high symptom profile and postoperative outcomes. METHODS: Seventy children (aged 10-17 years) scheduled for correction of idiopathic scoliosis completed pain and symptom surveys during their preoperative visit (ie, pain intensity [0-10 numeric rating scores], a pediatric version of the 2011 fibromyalgia survey criteria [including pain locations and symptom severity scale], neuropathic pain symptoms [painDETECT], and Patient-Reported Outcome Measurement System measures of fatigue, depression, function, pain interference, and pain catastrophizing)...
March 17, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28319481/application-of-telepractice-for-head-and-neck-cancer-management-a-review-of-speech-language-pathology-service-models
#9
Elizabeth C Ward, Laurelie R Wall, Clare L Burns, Bena Cartmill, Anne J Hill
PURPOSE OF REVIEW: Head and neck cancer (HNC) is a complex and heterogeneous disease, requiring specialist intervention from a multidisciplinary team including speech language pathology (SLP). Unfortunately, multiple patient and service-related challenges exist which currently limit equitable access to SLP support for all individuals. This review highlights the existing evidence for different telepractice models designed to help patients and services optimize management of swallowing and communication disorders arising from HNC...
March 17, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/28319336/impact-of-mild-to-severe-hemophilia-on-engagement-in-recreational-activities-by-us-men-women-and-children-with-hemophilia-b-the-bridging-hemophilia-b-experiences-results-and-opportunities-into-solutions-b-hero-s-study
#10
Kimberly Baumann, Grace Hernandez, Michelle Witkop, Skye Peltier, Spencer Dunn, Susan Cutter, Neil Frick, Kimberly Haugstad, Christine Guelcher, Mary Jane Frey, Dawn Rotellini, David B Clark, Neeraj N Iyer, David L Cooper
The psychosocial impact of hemophilia on activities was recently investigated in the Hemophilia Experiences, Results and Opportunities (HERO) study (675 people with hemophilia and 561 caregivers of children with hemophilia in 10 countries). The impact of hemophilia B may not be accurately reflected in the HERO results, as ~75% of respondents described issues affecting males with hemophilia A. To address the needs of this population, the Bridging Hemophilia B Experiences, Results and Opportunities Into Solutions (B-HERO-S) was developed as a pilot study in the United States in collaboration with the hemophilia community...
April 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28319274/intraoperative-optical-coherence-tomography-for-soft-tissue-sarcoma-differentiation-and-margin-identification
#11
Kelly J Mesa, Laura E Selmic, Paritosh Pande, Guillermo L Monroy, Jennifer Reagan, Jonathan Samuelson, Elizabeth Driskell, Joanne Li, Marina Marjanovic, Eric J Chaney, Stephen A Boppart
BACKGROUND AND OBJECTIVE: Sarcomas are rare but highly aggressive tumors, and local recurrence after surgical excision can occur in up to 50% cases. Therefore, there is a strong clinical need for accurate tissue differentiation and margin assessment to reduce incomplete resection and local recurrence. The purpose of this study was to investigate the use of optical coherence tomography (OCT) and a novel image texture-based processing algorithm to differentiate sarcoma from muscle and adipose tissue...
March 20, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28319204/responses-to-others-pain-in-adults-with-autistic-traits-the-influence-of-gender-and-stimuli-modality
#12
Jing Meng, Zuoshan Li, Lin Shen
Individuals with autism-spectrum disorder (ASD) exhibit impairments in response to others' pain. Evidence suggests that features of autism are not restricted to individuals with ASD, and that autistic traits vary throughout the general population. To investigate the association between autistic traits and the responses to others' pain in typically developing adults, we employed the Autism-Spectrum Quotient (AQ) to quantify autistic traits in a group of 1670 healthy adults and explored whether 60 participants (30 males and 30 females) with 10% highest AQ scores (High-AQ) would exhibit difficulties in the responses to others' pain relative to 60 participants (30 males and 30 females) with 10% lowest AQ scores (Low-AQ)...
2017: PloS One
https://www.readbyqxmd.com/read/28319072/long-term-follow-up-of-a-retrospective-comparison-of-reduced-intensity-conditioning-and-conventional-high-dose-conditioning-for-allogeneic-transplantation-from-matched-related-donors-in-myelodysplastic-syndromes
#13
R Martino, A Henseler, M van Lint, N Schaap, J Finke, D Beelen, S Vigouroux, E P Alessandrino, G J Mufti, J H Veelken, B Bruno, I Yakoub-Agha, L Volin, J Maertens, R Or, V Leblond, M Rovira, P Kalhs, A F Alvarez, A Vitek, J Sierra, E Wagner, M Robin, T de Witte, N Kröger
This study shows the long-term updated outcomes of a multicenter retrospective study which analyzed 843 patients with myelodysplastic syndrome (MDS) who underwent transplantation with an HLA-identical sibling donor with either reduced-intensity conditioning (RIC) in 213 patients, or standard myeloablative conditioning (MAC) in 630 patients. In multivariate analysis, the 13-year relapse rate was significantly increased after RIC (31% after MAC vs 48% in RIC; HR, 1.5; 95% CI, 1.1-1.9; P=0.04), but with no differences in overall survival (OS) (30% after MAC vs 27% in RIC; P=0...
March 20, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28319041/practical-use-of-a-plastic-scintillator-for-quality-assurance-of-electron-beam-therapy
#14
Katsunori Yogo, Yuya Tatsuno, Masato Tsuneda, Yuki Aono, Daiki Mochizuki, Yoshiki Fujisawa, Akihiro Matsushita, Minoru Ishigami, Hiromichi Ishiyama, Kazushige Hayakawa
Quality assurance (QA) of the clinical electron beam is essential for performing accurate and safe radiation therapy. However, with advances in radiation therapy, QA tends to be labor-intensive and time consuming. Here, we propose the practical use of a tissue-equivalent plastic scintillator for quick and easy QA of clinical electron beams. This tool enabled us to verify simultaneously the constancy of output, beam quality, depth and lateral dose profiles during monthly QAs at lower doses of irradiation (small MUs)...
March 20, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28319005/prediction-of-treatment-response-in-patients-with-newly-diagnosed-type-2-diabetes-the-skaraborg-diabetes-register
#15
Miriam Pikkemaat, Olle Melander, Per Hjerpe, Kristina Bengtsson Boström
AIMS: Type 2 diabetes is associated with cardiovascular complications. It is largely unknown which patients have poor treatment response and high complication risk; biomarkers are studied for this purpose. The aim of the study was to investigate the association between clinical factors such as HbA1c, level of biomarkers (C-peptide, copeptin) at diagnosis and changes in HbA1c, blood pressure or body mass index (BMI) after five years. METHODS: Clinical data and blood samples from 460 newly diagnosed type 2 diabetes patients from the Skaraborg diabetes register (SDR) at diagnosis and after 5years and were analyzed with linear and logistic regressions...
March 6, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28318977/aromatic-decoration-determines-the-formation-of-anthocyanic-vacuolar-inclusions
#16
Kalyani Kallam, Ingo Appelhagen, Jie Luo, Nick Albert, Huaibi Zhang, Simon Deroles, Lionel Hill, Kim Findlay, Øyvind M Andersen, Kevin Davies, Cathie Martin
Anthocyanins are some of the most widely occurring secondary metabolites in plants, responsible for the orange, red, purple, and blue colors of flowers and fruits and red colors of autumn leaves. These pigments accumulate in vacuoles, and their color is influenced by chemical decorations, vacuolar pH, the presence of copigments, and metal ions. Anthocyanins are usually soluble in the vacuole, but in some plants, they accumulate as discrete sub-vacuolar structures. Studies have distinguished intensely colored intra-vacuolar bodies observed in the cells of highly colored tissues, termed anthocyanic vacuolar inclusions (AVIs), from more globular, membrane-bound anthocyanoplasts...
March 8, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28318952/glycaemic-variability-in-patients-with-severe-sepsis-or-septic-shock-admitted-to-an-intensive-care-unit
#17
L M Silveira, A Basile-Filho, E A Nicolini, C A M Dessotte, G C S Aguiar, A M Stabile
BACKGROUND: Sepsis is associated with morbidity and mortality, which implies high costs to the global health system. Metabolic alterations that increase glycaemia and glycaemic variability occur during sepsis. OBJECTIVE: To verify mean body glucose levels and glycaemic variability in Intensive Care Unit (ICU) patients with severe sepsis or septic shock. METHOD: Retrospective and exploratory study that involved collection of patients' sociodemographic and clinical data and calculation of severity scores...
March 15, 2017: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/28318888/characterization-of-the-lung-parenchyma-using-ultrasound-multiple-scattering
#18
Kaustav Mohanty, John Blackwell, Thomas Egan, Marie Muller
The purpose of the study described here was to showcase the application of ultrasound to quantitative characterization of the micro-architecture of the lung parenchyma to predict the extent of pulmonary edema. The lung parenchyma is a highly complex and diffusive medium for which ultrasound techniques have remained qualitative. The approach presented here is based on ultrasound multiple scattering and exploits the complexity of ultrasound propagation in the lung structure. The experimental setup consisted of a linear transducer array with an 8-MHz central frequency placed in contact with the lung surface...
March 16, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28318789/transport-of-microplastics-by-two-collembolan-species
#19
Stefanie Maaß, Daniel Daphi, Anika Lehmann, Matthias C Rillig
Plastics, despite their great benefits, have become a ubiquitous environmental pollutant, with microplastic particles having come into focus most recently. Microplastic effects have been intensely studied in aquatic, especially marine systems; however, there is lack of studies focusing on effects on soil and its biota. A basic question is if and how surface-deposited microplastic particles are transported into the soil. We here wished to test if soil microarthropods, using Collembola, can transport these particles over distances of centimeters within days in a highly controlled experimental set-up...
March 16, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28318622/computer-assisted-topological-analysis-of-renal-allograft-inflammation-adds-to-risk-evaluation-at-diagnosis-of-humoral-rejection
#20
Antoine Sicard, Vannary Meas-Yedid, Maud Rabeyrin, Alice Koenig, Stephanie Ducreux, Frederique Dijoud, Valerie Hervieu, Lionel Badet, Emmanuel Morelon, Jean Christophe Olivo-Marin, Valerie Dubois, Olivier Thaunat
Antibody-mediated rejection is associated with heterogeneous kidney allograft outcomes. Accurate evaluation of risk for graft loss at time of diagnosis is necessary to offer personalized treatment. In contrast with serological and molecular assessment, morpho-histological evaluation of antibody-mediated rejection lesions has not significantly evolved. This relies on Banff classifications designed to be of diagnostic discriminatory power rather than prognostic and face quantitative and qualitative limitations...
March 15, 2017: Kidney International
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