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https://www.readbyqxmd.com/read/28532042/ph-responsive-poly-aspartic-acid-hydrogel-coated-magnetite-nanoparticles-for-biomedical-applications
#1
Jaime Vega-Chacón, María Isabel Amaya Arbeláez, Janaina Habib Jorge, Rodrigo Fernando C Marques, Miguel Jafelicci
A novel multifunctional nanosystem formed by magnetite nanoparticles coated with pH-responsive poly(aspartic acid) hydrogel was developed. Magnetite nanoparticles (Fe3O4) have been intensively investigated for biomedical applications due to their magnetic properties and dimensions similar to the biostructures. Poly(aspartic acid) is a water-soluble, biodegradable and biocompatible polymer, which features makes it a potential candidate for biomedical applications. The nanoparticles surface modification was carried out by crosslinking polysuccinimide on the magnetite nanoparticles surface and hydrolyzing the succinimide units in mild alkaline medium to obtain the magnetic poly(aspartic acid) hydrogel...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531867/the-efficacy-of-steroids-for-postoperative-persistent-inflammatory-reaction-in-a-patient-with-barium-peritonitis-a-case-report
#2
Hirofumi Kojima, Shozo Hojo, Takahiro Manabe, Shiori Demura, Shinichi Sekine, Kazuto Shibuya, Isaya Hashimoto, Isaku Yoshioka, Tomoyuki Okumura, Takuya Nagata, Tsutomu Fujii
INTRODUCTION: Barium peritonitis is a serious and life-threatening disease requiring intensive care. Residual barium in the intraperitoneal cavity can cause persistent inflammation, postoperatively. PRESENTATION OF CASE: An 80-year-old woman was admitted to our hospital because of abdominal pain and vomiting after barium meal examination. Physical and radiographic examination showed sigmoid colon perforation. Barium sulfate extravasation was noted in the intraperitoneal cavity...
May 15, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28531841/positive-affective-functioning-in-anhedonic-individuals-daily-life-anything-but-flat-and-blunted
#3
V E Heininga, E Van Roekel, J J Ahles, A J Oldehinkel, A H Mezulis
BACKGROUND: Anhedonia, the decreased interest and pleasure, is often described as 'flat' or 'blunted' positive affect (PA). Yet, little is known about PA functioning in anhedonic individuals' daily lives. The current study investigates PA reactivity to pleasurable experiences in anhedonia together with its relevant temporal dynamics (i.e., variability, instability, and inertia), and expands current knowledge by exploring the role of arousal therein. METHODS: Using the Experience Sampling Method (ESM), we collected 90 assessments of real-life PA experiences across 30 days in 18-24 year old individuals with anhedonia (N=69) and without anhedonia (N=69)...
April 21, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28531826/how-many-familial-hypercholesterolemia-patients-are-eligible-for-pcsk9-inhibition
#4
Luis Masana, Nuria Plana, Sofia Pérez-Calahorra, Daiana Ibarretxe, Itziar Lamiquiz-Moneo, Juan Pedro-Botet, Manuel Suárez-Tembra, Pedro Valdivielso, Emilio Ortega, Fernando Civeira
BACKGROUND AND AIMS: Familial hypercholesterolemia (FH) is a high cardiovascular risk condition. Less than 20% of patients achieve the LDL targets. Although PCSK9 inhibitors improve control and reduce cardiovascular events, official recommendations for their use are restrictive. We aim to assess the number of FH patients suitable for PCSK9 inhibition according to the European guidelines. METHODS: A total of 2685 FH patients, with a minimum follow-up of 6 months, included in the Dyslipidemia Registry of the Spanish Arteriosclerosis Society, were sorted according to the intensity of their lipid-lowering therapy (LLT) and LDL cholesterol levels achieved...
May 12, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28531789/do-picu-patients-meet-technical-criteria-for-performing-indirect-calorimetry
#5
Megan R Beggs, Gonzalo Garcia Guerra, Bodil M K Larsen
BACKGROUND & AIMS: Indirect calorimetry (IC) is considered gold standard for assessing energy needs of critically ill children as predictive equations and clinical status indicators are often unreliable. Accurate assessment of energy requirements in this vulnerable population is essential given the high risk of over or underfeeding and the consequences thereof. The proportion of patients and patient days in pediatric intensive care (PICU) for which energy expenditure (EE) can be measured using IC is currently unknown...
October 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531559/per-and-polyfluoroalkyl-substances-in-firefighting-foam-concentrates-and-water-samples-collected-near-sites-impacted-by-the-use-of-these-foams
#6
Xavier Dauchy, Virginie Boiteux, Cristina Bach, Christophe Rosin, Jean-François Munoz
To extinguish large-scale fuel fires, fluorosurfactant based foams (FSBFs) were developed in the 1960s and have been used ever since. In this study, 154 per- and polyfluoroalkyl substances (PFASs) including 122 emerging PFASs used as surfactants in FSBFs were sought in nine different foam concentrates. Field investigations were also carried out in the vicinity of four sites where FSBFs are or were intensively used (two airports, a training center for firefighters and an oil storage depot after a large explosion)...
May 13, 2017: Chemosphere
https://www.readbyqxmd.com/read/28531396/translation-and-adaptation-of-the-nutric-score-to-identify-critically-ill-patients-who-benefit-the-most-from-nutrition-therapy
#7
Mariane Rosa, Daren K Heyland, Daieni Fernandes, Estela I Rabito, Manoela L Oliveira, Aline Marcadenti
INTRODUCTION AND OBJECTIVES: Due to the scarcity of tools to assess the nutritional risk in critically ill patients, the NUTrition Risk in the Critically ill Score (NUTRIC Score) was developed and validated primarily in a limited population to quantify the risk of adverse events that may be modified by aggressive nutrition therapy. The objective of this study was to translate and adapt the NUTRIC Score into Portuguese language for further demonstrate its feasibility and clinical utility in Brazilian Intensive Care Units (ICUs)...
August 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531355/flexible-multiferroic-bulk-heterojunction-with-giant-magnetoelectric-coupling-via-the-van-der-waals-epitaxy
#8
Ying-Hao Chu, Tahta Amrillah, Yugandhar Bitla, Kwangwoo Shin, Tiannan Yang, Ying-Hui Hsieh, Yu-You Chiou, Heng-Jui Liu, Thi Hien Do, Dong Su, Yi-Chun Chen, Shien-Uang Jen, Long-Qing Chen, Kee Hoon Kim, Jenh-Yih Juang
Magnetoelectric nanocomposites have been a topic of intense research due to their profound potential in the applications of electronic devices based on the spintronic technology. Nevertheless, in spite of significant progress made in the growth of high-quality nanocomposite thin films, the substrate clamping effect still remains as a major hurdle in realizing the ultimate magnetoelectric coupling. To overcome this obstacle, an alternative strategy of fabricating self-assembled ferroelectric-ferrimagnetic bulk heterojunction on flexible muscovite via the van der Waals epitaxy is adopted...
May 22, 2017: ACS Nano
https://www.readbyqxmd.com/read/28531215/association-of-cord-blood-chemokines-and-other-biomarkers-with-neonatal-complications-following-intrauterine-inflammation
#9
Yoshikazu Otsubo, Kunio Hashimoto, Taro Kanbe, Muneichiro Sumi, Hiroyuki Moriuchi
BACKGROUND: Intrauterine inflammation has been associated with preterm birth and neonatal complications. Few reports have comprehensively investigated multiple cytokine profiles in cord blood and precisely identified surrogate markers for intrauterine inflammation. AIM: To identify the cytokines and surrogate markers associated with intrauterine inflammation and subsequent neonatal complications. PATIENTS AND METHODS: We analyzed cord blood samples from 135 patients admitted to the neonatal intensive care unit at Sasebo City General Hospital...
2017: PloS One
https://www.readbyqxmd.com/read/28531213/perfusion-mr-imaging-detection-of-carcinoma-arising-from-preexisting-salivary-gland-pleomorphic-adenoma-by-computer-assisted-analysis-of-time-signal-intensity-maps
#10
Ikuo Katayama, Sato Eida, Shuichi Fujita, Yuka Hotokezaka, Misa Sumi, Takashi Nakamura
Tumor perfusion can be evaluated by analyzing the time-signal intensity curve (TIC) after dynamic contrast-enhanced (DCE) MR imaging. Accordingly, TIC profiles are characteristic of some benign and malignant salivary gland tumors. A carcinoma ex pleomorphic adenoma (CXPA) arises from a long-standing pleomorphic adenoma (PA) and has a distinctive prognostic risk depending on the tumor growth potential such as invasion beyond the preexisting capsule. Differentiating CXPA from PA can be very challenging. In this study, we have attempted to discriminate CXPA from PA based on a two-dimensional TIC mapping algorithm...
2017: PloS One
https://www.readbyqxmd.com/read/28531201/evolutionary-forces-affecting-synonymous-variations-in-plant-genomes
#11
Yves Clément, Gautier Sarah, Yan Holtz, Felix Homa, Stéphanie Pointet, Sandy Contreras, Benoit Nabholz, François Sabot, Laure Sauné, Morgane Ardisson, Roberto Bacilieri, Guillaume Besnard, Angélique Berger, Céline Cardi, Fabien De Bellis, Olivier Fouet, Cyril Jourda, Bouchaib Khadari, Claire Lanaud, Thierry Leroy, David Pot, Christopher Sauvage, Nora Scarcelli, James Tregear, Yves Vigouroux, Nabila Yahiaoui, Manuel Ruiz, Sylvain Santoni, Jean-Pierre Labouisse, Jean-Louis Pham, Jacques David, Sylvain Glémin
Base composition is highly variable among and within plant genomes, especially at third codon positions, ranging from GC-poor and homogeneous species to GC-rich and highly heterogeneous ones (particularly Monocots). Consequently, synonymous codon usage is biased in most species, even when base composition is relatively homogeneous. The causes of these variations are still under debate, with three main forces being possibly involved: mutational bias, selection and GC-biased gene conversion (gBGC). So far, both selection and gBGC have been detected in some species but how their relative strength varies among and within species remains unclear...
May 22, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28530849/allergic-bronchopulmonary-aspergillosis-in-cystic-fibrosis-mr-imaging-of-airway-mucus-contrasts-as-a-tool-for-diagnosis
#12
Gaël Dournes, Patrick Berger, John Refait, Julie Macey, Stephanie Bui, Laurence Delhaes, Michel Montaudon, Olivier Corneloup, Jean-François Chateil, Roger Marthan, Michaël Fayon, François Laurent
Purpose To assess the diagnostic accuracy of mucus contrast characterization by using magnetic resonance (MR) imaging to discriminate allergic bronchopulmonary aspergillosis (ABPA) in cystic fibrosis (CF). Materials and Methods The study was approved by the local Ethics Committee, and all patients or their parents gave written informed consent. One hundred ten consecutive patients with CF were screened between January 2014 and July 2015. All patients underwent a non-contrast material-enhanced MR protocol that included routine T1-weighted and T2-weighted sequences...
May 22, 2017: Radiology
https://www.readbyqxmd.com/read/28530831/blue-shifted-green-fluorescent-protein-homologs-are-brighter-than-enhanced-green-fluorescent-protein-under-two-photon-excitation
#13
Rosana S Molina, Tam M Tran, Robert E Campbell, Gerard Glenn Lambert, Anya Salih, Nathan C Shaner, Thomas E Hughes, Mikhail Drobizhev
Fluorescent proteins (FPs) are indispensable markers for two-photon imaging of live tissue, especially in the brains of small model organisms. The quantity of physiologically relevant data collected, however, is limited by heat-induced damage of the tissue due to the high intensities of the excitation laser. We seek to minimize this damage by developing FPs with improved brightness. Among FPs with the same chromophore structure, the spectral properties can vary widely due to differences in the local protein environment...
May 22, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28530772/characteristics-of-the-injuries-of-syrian-refugees-sustained-during-the-civil-war
#14
Betül Kocamer Şimşek, Mehmet Dokur, Erdal Uysal, Necdet Çalıker, Oruç Numan Gökçe, İbrahim Kürşat Deniz, Murat Uğur, Murat Geyik, Mehmet Kaya, Güner Dağlı
BACKGROUND: During a war, many civilians are severely injured by firearms, bombs, and shrapnel. The triage of war injuries involves difficult and complicated processes requiring surgical procedures and patient monitoring in the Intensive Care Unit (ICU) of hospitals. In this study, we examine the demographic, traumatic, and critical care characteristics of cases injured during the civil war in Syria and requiring emergency surgery. METHODS: Electronic data of the traumatic, surgical, and ICU monitoring features of 707 patients admitted to Kilis Public Hospital between March 2012 and January 2013 were analyzed retrospectively RESULTS: Most of the patients reported having been injured due to firearms (83...
May 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/28530507/the-reliability-and-sensitivity-of-performance-measures-in-a-novel-pace-bowling-test
#15
Simon A Feros, Warren B Young, Brendan J O'Brien
OBJECTIVES: Evaluate the reliability and sensitivity of performance measures in a novel pace bowling test. METHODS: Thirteen male amateur club fast bowlers completed a novel pace bowling test on two separate occasions, 4-7 days apart. Participants delivered 48 balls (8 overs), at five targets on a suspended sheet, situated behind a 'live' batter who stood in a right-handed and left-handed stance for an equal amount of deliveries. Delivery instruction was frequently changed, with all deliveries executed in a pre-planned sequence...
May 22, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28530505/ingestion-of-sodium-bicarbonate-nahco3-following-a-fatiguing-bout-of-exercise-accelerates-post-exercise-acid-base-balance-recovery-and-improves-subsequent-high-intensity-cycling-time-to-exhaustion
#16
Lewis A Gough, Steven Rimmer, Callum J Osler, Matthew F Higgins
This study evaluated the ingestion of sodium bicarbonate (NaHCO3) on post-exercise acid-base balance recovery kinetics and subsequent high-intensity cycling time to exhaustion. In a counterbalanced, crossover design, nine healthy and active males (age: 23±2 years, height: 179±5 cm, body mass: 74±9 kg, peak mean minute power (WPEAK) 256±45 W, peak oxygen uptake (V̇O2PEAK) 46±8 ml.kg(-1).min(-1)) performed a graded incremental exercise test, two familiarisation and two experimental trials. Experimental trials consisted of cycling to volitional exhaustion (TLIM1) at 100% WPEAK on two occasions (TLIM1 and TLIM2) interspersed by a 90 min passive recovery period...
May 22, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/28530391/single-bead-quantification-of-peptide-loading-distribution-for-one-bead-one-compound-library-synthesis-using-confocal-raman-spectroscopy
#17
Yuchen Tang, Yann Thillier, Ruiwu Liu, Xiaocen Li, Kit S Lam, Tingjuan Gao
We report an analytical method to determine peptide loading of "one-bead one-compound" (OBOC) combinatorial peptide libraries at single-bead level. The quantification is based on a linear relationship between the amount of N-terminal amino groups on individual peptide beads and the intensity of Raman signal obtained from a specifically designed reporter labeled on amino groups. Confocal Raman spectroscopy was employed to characterize peptide loading of beads with defined peptide sequences and from OBOC combinatorial peptide libraries...
May 22, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28530342/-behavioral-physiological-and-morphological-characteristics-associated-with-post-traumatic-response-to-continuous-exposure-versus-alternate-exposure-in-an-animal-model-of-post-traumatic-stress-disorder
#18
Ishay Ostfeld, Zeev Kaplan, Hagit Cohen
AIMS: The aim of this study was to approximate these conditions in an animal model of post-traumatic stress disorder (PTSD). More specifically, the neurobiological basis of these conditions, focusing on stress-related behavioral changes, HPA-axis and morphological were evaluated. The intention was to employ this well-validated, reproducible and reliable model for PTSD, to elicit data which will provide some guidance in the planning of a prospective study involving military personal. BACKGROUND: Combat personnel are exposed to significant stress and hardship, both physical and emotional, during their service and especially during active combat...
December 2016: Harefuah
https://www.readbyqxmd.com/read/28530325/-diversity-in-product-selection-and-thresholds-for-platelets-transfusion-in-neonates-and-premature-infants
#19
Shraga Aviner, Ornit Cohen, Faid El-Ubra, Vered Yahalom, Haim Bibi, Shmuel Zangen
INTRODUCTION: Many premature and full-term newborns receive prophylactic platelet transfusions to prevent bleeding, particularly the most prevalent one, i.e, intracranial hemorrhages. However, the platelet count threshold above which bleeding is prevented and the efficacy of platelet transfusion in thrombocytopenic neonates, have yet to be established. Therefore, inter-Neonatal Intensive Care Units (NICU) variations in treatment indications and practices are expected. Considerable inter-NICU variations will emphasize the need for guidelines on platelet transfusions to neonates and premature infants...
August 2016: Harefuah
https://www.readbyqxmd.com/read/28530304/visualization-of-structural-evolution-and-phase-distribution-of-a-lithium-vanadium-oxide-li1-1v3o8-electrode-via-an-operando-and-in-situ-energy-dispersive-x-ray-diffraction-technique
#20
Qing Zhang, Andrea M Bruck, David C Bock, Jing Li, Varun Sarbada, Robert Hull, Eric A Stach, Kenneth J Takeuchi, Esther S Takeuchi, Amy C Marschilok
Li1+nV3O8 (n = 0-0.2) has been extensively investigated as a cathode material for Li ion batteries because of its superior electrochemical properties including high specific energy and good rate capability. In this paper, a synchrotron based energy dispersive X-ray diffraction (EDXRD) technique was employed to profile the phase transitions and the spatial phase distribution of a Li1.1V3O8 electrode during electrochemical (de)lithiation in situ and operando. As annealing temperature during the preparation of the Li1...
May 22, 2017: Physical Chemistry Chemical Physics: PCCP
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