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https://www.readbyqxmd.com/read/28215040/who-should-receive-a-transplant-for-acute-lymphoblastic-leukaemia
#1
REVIEW
Rishi Dhawan, David I Marks
Allogeneic haematopoietic cell transplantation continues to be an important curative therapy for acute lymphoblastic leukaemia (ALL). Traditionally accepted indications for allografting adult ALL patients need reevaluation in light of outcomes with paediatric-like intensive regimens. Minimal residual disease status and oncogenetics can be used for restratification of standard risk patients. A greater body of data on haematopoietic cell transplantation (HCT) outcomes from haploidentical and cord blood donor sources has been generated in recent years...
February 18, 2017: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/28214989/exposure-response-analyses-of-blood-pressure-and-heart-rate-changes-for-methylphenidate-in-healthy-adults
#2
Liang Li, Yaning Wang, Ramana S Uppoor, Mehul U Mehta, Tiffany Farchione, Mitchell V Mathis, Hao Zhu
The aim of the study was to evaluate the exposure-response (E-R) relationships of blood pressure (BP) and heart rate (HR) changes in healthy adults taking methylphenidate (MPH). Intensive time profiles of BP and HR from healthy adults in placebo and MPH treatment arms of seven clinical trials from the FDA internal database were utilized for this analysis. The analysis model contains a circadian component for placebo effect and an E-R component to describe drug effect. Internal validation was performed using goodness-of-fit plots and visual predictive check...
February 18, 2017: Journal of Pharmacokinetics and Pharmacodynamics
https://www.readbyqxmd.com/read/28214948/reduced-anticoagulation-variability-in-patients-on-warfarin-monitored-with-fiix-prothrombin-time-associates-with-reduced-thromboembolism-the-fiix-trial
#3
Alma Rut Oskarsdóttir, Brynja R Gudmundsdottir, Olafur S Indridason, Sigrun H Lund, David O Arnar, Einar S Bjornsson, Magnus K Magnusson, Hulda M Jensdottir, Brynjar Vidarsson, Charles W Francis, Pall T Onundarson
Fiix-prothrombin time (Fiix-PT) differs from traditional PT in being affected by reduced factor (F) II or FX only. In the randomized controlled Fiix-trial, patients on warfarin monitored with Fiix-PT (Fiix-warfarin patients) had fewer thromboembolisms (TE), similar major bleeding (MB) and more stable anticoagulation than patients monitored with PT (PT-warfarin patients). In the current Fiix-trial report we analyzed how reduced anticoagulation variability during Fiix-PT monitoring was reflected in patients with TE or bleeding...
February 18, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28214786/cost-effectiveness-of-risk-reducing-surgeries-in-preventing-hereditary-breast-and-ovarian-cancer
#4
Michael G Schrauder, Lisa Brunel-Geuder, Lothar Häberle, Marius Wunderle, Juliane Hoyer, André Reis, Rüdiger Schulz-Wendtland, Matthias W Beckmann, Michael P Lux
OBJECTIVES: Risk-reducing surgeries are a feasible option for mitigating the risk in individuals with inherited susceptibility to cancer, but are the procedures cost-effective in the current health-care system in Germany? This study compared the health-care costs for bilateral risk-reducing mastectomy (BRRM) and risk-reducing (bilateral) salpingo-oophorectomy (RRSO) with cancer treatment costs that could potentially be prevented. PATIENTS AND METHODS: The analysis is based on interdisciplinary consultations with individuals with a high familial risk for breast and ovarian cancer at the University Breast Center for Franconia (Germany) between 2009 and 2013 (370 consultations; 44 patients with BRCA1 mutations and 26 with BRCA2 mutations)...
February 16, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28214741/identifying-social-smoking-u-s-young-adults-using-an-empirically-driven-approach
#5
Andrea C Villanti, Amanda L Johnson, Jessica M Rath, Valerie Williams, Donna M Vallone, David B Abrams, Donald Hedeker, Robin J Mermelstein
The phenomenon of "social smoking" emerged in the past decade as an important area of research, largely due to its high prevalence in young adults. The purpose of this study was to identify classes of young adult ever smokers based on measures of social and contextual influences on tobacco use. Latent class models were developed using social smoking measures, and not the frequency or quantity of tobacco use. Data come from a national sample of young adult ever smokers aged 18-24 (Truth Initiative Young Adult Cohort Study, N=1564)...
February 10, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28214616/exploring-factors-influencing-low-back-pain-in-people-with-non-dysvascular-lower-limb-amputation-a-national-survey
#6
Hemakumar Devan, Paul Hendrick, Leigh Hale, Allan Carman, Michael P Dillon, Daniel Cury Ribeiro
BACKGROUND: Chronic low back pain (LBP) is a common musculoskeletal impairment in people with lower limb amputation. Given the multifactorial nature of LBP, exploring the factors influencing the presence and intensity of LBP is warranted. OBJECTIVE: To investigate which physical, personal, and amputee-specific factors predicted presence and intensity of low back pain (LBP) in persons with non-dysvascular transfemoral (TFA) and transtibial amputation (TTA). DESIGN: A retrospective cross-sectional survey SETTING: A national random sample of people with non-dysvascular TFA and TTA...
February 15, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28214368/evaluation-of-deformable-image-registration-between-external-beam-radiotherapy-and-hdr-brachytherapy-for-cervical-cancer-with-a-3d-printed-deformable-pelvis-phantom
#7
Noriyuki Kadoya, Yuya Miyasaka, Yujiro Nakajima, Yoshihiro Kuroda, Kengo Ito, Mizuki Chiba, Kiyokazu Sato, Suguru Dobashi, Takaya Yamamoto, Noriyoshi Takahashi, Masaki Kubozono, Ken Takeda, Keiichi Jingu
PURPOSE: In this study, we developed a 3D-printed deformable pelvis phantom for evaluating spatial DIR accuracy. We then evaluated the spatial DIR accuracies of various DIR settings for cervical cancer. METHODS: A deformable female pelvis phantom was created based on patient CT data using 3D printing. To create the deformable uterus phantom, we first 3D printed both a model of uterus and a model of the internal cavities of the vagina and uterus. We then made a mold using the 3D printed uterus phantom...
February 18, 2017: Medical Physics
https://www.readbyqxmd.com/read/28214128/robotic-arch-catheter-placement-reduces-cerebral-embolization-during-thoracic-endovascular-aortic-repair-tevar
#8
A H Perera, C V Riga, L Monzon, R G Gibbs, C D Bicknell, M Hamady
OBJECTIVE: Stroke caused by cerebral embolization constitutes a principal risk during arch manipulation and thoracic endovascular aortic repair (TEVAR). This study investigates the incidence of cerebral embolization during catheter placement in the aortic arch, and compares robotic and manual techniques. METHODS: Intra-operative transcranial Doppler (TCD) was performed in 11 patients undergoing TEVAR. Wire and catheter placement in the arch was performed by two experienced operators...
February 14, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28214041/why-intensity-is-not-a-bad-word-optimizing-health-status-at-any-age
#9
REVIEW
Gary R Hunter, Eric P Plaisance, Stephen J Carter, Gordon Fisher
Age-related declines in health and function make locomotion increasingly difficult leading to reductions in non-exercise activity thermogenesis (NEAT), skeletal muscle size and strength, and increased adiposity. Exercise is an important strategy to attenuate loss of function through the life cycle. Despite claims to the contrary, high-intensity exercise is important for the prevention of obesity and sarcopenia with advancing age. Therefore, the purpose of this mini-review is to present literature supporting the contention that low volume, high-intensity aerobic and/or resistance training can slow sarcopenia, sustain ease of movement, stimulate NEAT, and attenuate the accretion of fat mass...
February 9, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28213914/novel-method-to-assess-intrinsic-heart-rate-recovery-in-ambulatory-ecg-recordings-tracks-cardioprotective-effects-of-chronic-autonomic-regulation-therapy-in-patients-enrolled-in-the-anthem-hf-study
#10
Gerrard M Carlson, Imad Libbus, Badri Amurthur, Bruce H KenKnight, Richard L Verrier
BACKGROUND: Postexercise heart rate recovery (HRR) is a powerful and independent predictor of mortality. Autonomic regulation therapy (ART) with chronic vagus nerve stimulation (VNS) has been shown to improve ventricular function in patients with chronic heart failure. However, the effect of ART on HRR in patients with heart failure remains unknown. METHODS: A new measure involving quantification of intrinsic HRR was developed for 24-hr ambulatory ECG (AECG) recordings based on spontaneous heart rate changes observed during daily activity in patients with symptomatic heart failure and reduced ejection fraction...
February 17, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28213900/c-h-direct-arylated-6h-indolo-2-3-b-quinoxaline-derivative-as-thickness-dependent-hole-injection-layer
#11
Dai Dong, Da Fang, Hairong Li, Caixia Zhu, Xianghua Zhao, Jiewei Li, Lingzhi Jin, Linghai Xie, Lin Chen, Jianfeng Zhao, Hongmei Zhang, Wei Huang
A novel perfluoro-1,4-phenylenyl 6H-indolo[2,3-b]quinoxaline derivative (TFBIQ) was designed and synthesized via C-H direct arylation. The opto-electrical properties of the obtained TFBIQ were fully characterized by UV-vis and photoluminescence, cyclic voltammetry, film morphology and Alq3-based green organic light emitting diodes (OLEDs). Device A using 0.5 nm thick TFBIQ as the interfacial modification layer exhibits the best five advantages of device performance including the lowest minimum turn-on voltage (Von) as low as 3...
February 18, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28213832/dynamic-fluorescence-microscopy-of-cellular-uptake-of-intercalating-model-drugs-by-ultrasound-activated-microbubbles
#12
B H A Lammertink, R Deckers, M Derieppe, I De Cock, I Lentacker, G Storm, C T W Moonen, C Bos
PURPOSE: The combination of ultrasound and microbubbles can facilitate cellular uptake of (model) drugs via transient permeabilization of the cell membrane. By using fluorescent molecules, this process can be studied conveniently with confocal fluorescence microscopy. This study aimed to investigate the relation between cellular uptake and fluorescence intensity increase of intercalating model drugs. PROCEDURES: SYTOX Green, an intercalating fluorescent dye that displays >500-fold fluorescence enhancement upon binding to nucleic acids, was used as a model drug for ultrasound-induced cellular uptake...
February 17, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28213793/automation-of-peak-tracking-analysis-of-stepwise-perturbed-nmr-spectra
#13
Tommaso Banelli, Marco Vuano, Federico Fogolari, Andrea Fusiello, Gennaro Esposito, Alessandra Corazza
We describe a new algorithmic approach able to automatically pick and track the NMR resonances of a large number of 2D NMR spectra acquired during a stepwise variation of a physical parameter. The method has been named Trace in Track (TINT), referring to the idea that a gaussian decomposition traces peaks within the tracks recognised through 3D mathematical morphology. It is capable of determining the evolution of the chemical shifts, intensity and linewidths of each tracked peak.The performances obtained in term of track reconstruction and correct assignment on realistic synthetic spectra were high above 90% when a noise level similar to that of experimental data were considered...
February 17, 2017: Journal of Biomolecular NMR
https://www.readbyqxmd.com/read/28213633/associations-between-pain-catastrophizing-and-cognitive-fusion-in-relation-to-pain-and-upper-extremity-function-among-hand-and-upper-extremity-surgery-patients
#14
Sezai Özkan, Emily L Zale, David Ring, Ana-Maria Vranceanu
BACKGROUND: Patients who present to hand surgery practices are at increased risk of psychological distress, pain, and disability. Greater catastrophic thinking about pain is associated with greater pain intensity, and initial evidence suggest that, together, catastrophic thinking about pain and cognitive fusion (i.e., interpretation of thoughts as true) are associated with poorer pain outcomes. PURPOSE: We tested whether cognitive fusion or catastrophic thinking interacts in relation to pain and upper extremity physical function among patients seeking care from a hand surgeon...
February 17, 2017: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/28213597/retrospective-examination-of-lipid-lowering-treatment-patterns-in-a-real-world-high-risk-cohort-in-the-uk-in-2014-comparison-with-the-national-institute-for-health-and-care-excellence-nice-2014-lipid-modification-guidelines
#15
Dylan L Steen, Irfan Khan, David Ansell, Robert J Sanchez, Kausik K Ray
BACKGROUND: In 2014, guidelines from the National Institute for Health and Care Excellence (NICE) provided updated recommendations on lipid-modifying therapy (LMT). We assessed clinical practice contemporaneous to release of these guidelines in a UK general practice setting for secondary and high-risk primary-prevention populations, and extrapolated the findings to UK nation level. METHODS: Patients from The Health Improvement Network database with the following criteria were included: lipid profile in 2014 (index date); ≥20 years of age; ≥2 years representation in database prior to index; ≥1 statin indication either for atherosclerotic cardiovascular disease (ASCVD) or the non-ASCVD conditions high-risk diabetes mellitus and/or chronic kidney disease...
February 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28213304/photocatalytic-effects-of-titanium-dioxide-nanoparticles-on-aquatic-organisms-current-knowledge-and-suggestions-for-future-research
#16
REVIEW
Vena N Haynes, J Evan Ward, Brandon J Russell, Alexander G Agrios
Nanoparticles are entering natural systems through product usage, industrial waste and post-consumer material degradation. As the production of nanoparticles is expected to increase in the next decade, so too are predicted environmental loads. Engineered metal-oxide nanomaterials, such as titanium dioxide, are known for their photocatalytic capabilities. When these nanoparticles are exposed to ultraviolet radiation in the environment, however, they can produce radicals that are harmful to aquatic organisms...
February 9, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28213239/new-urea-modified-paper-substrate-for-enhanced-analytical-performance-of-negative-ion-mode-paper-spray-mass-spectrometry
#17
Jingjing Liu, Yan He, Shuo Chen, Ming Ma, Shouzuo Yao, Bo Chen
Electrospray ionization mass spectrometry (ESI-MS) analysis in the negative ion mode is adversely affected by ionization suppression caused by electrical discharge and the presence of salts. Paper spray mass spectrometry (PS-MS) also suffers from the above phenomenon, being built on principles similar to those of ESI. Herein, we report the use of a paper substrate modified by 1-[3-(trimethoxysilyl)propyl]urea to improve the sensitivity of quantitative PS-MS analysis in the negative ion mode. The obtained results demonstrated that the urea modified paper substrate can effectively bind anions and highly polar compounds in the sample solution, decreasing competitive ionization in the negative ion mode of PS-MS and significantly reducing the signal intensity of Cl(-) adducts...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28213221/a-novel-fluorescent-aptasensor-for-ultrasensitive-detection-of-microcystin-lr-based-on-single-walled-carbon-nanotubes-and-dapoxyl
#18
Seyed Mohammad Taghdisi, Noor Mohammad Danesh, Mohammad Ramezani, Narjes Ghows, Seyed Ali Mousavi Shaegh, Khalil Abnous
To assure water safety and protect human health, precise and simple analytical approaches are highly desired to determine low concentrations of microcystin-leucine-arginine (MC-LR), a toxin, in both water and serum samples. Herein, a simple, rapid and accurate aptamer-based fluorescent sensor was used for selective recognition of MC-LR, based on single-walled carbon nanotubes (SWNTs) as immobilizers, dapoxyl as a fluorescent dye, DAP-10 as a specific aptamer for dapoxyl and unmodified MC-LR aptamer (Apt) as a sensing ligand...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28213194/subcortical-mapping-using-an-electrified-cusa-in-pediatric-supratentorial-surgery
#19
Jonathan Roth, Akiva Korn, Yifat Bitan-Talmor, Rivka Kaufman, Margaret Ekstein, Shlomi Constantini
BACKGROUND: Intraoperative electrophysiology is increasingly used for various lesion resections, both in adult and pediatric brain surgery. Subcortical mapping is often used in adult surgery when lesions lie in proximity to the corticospinal tract (CST). We describe a novel technique of continuous subcortical mapping using an electrified Cavitron UltraSonic Aspirator (CUSA) in children with supratentorial lesions. METHODS: We evaluated the method of subcortical mapping using a CUSA as a stimulation probe...
February 14, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28213140/a-novel-sensor-for-determination-of-naproxen-based-on-change-in-localized-surface-plasmon-peak-of-functionalized-gold-nanoparticles
#20
Javad Khodaveisi, Ali Mohammad Haji Shabani, Shayessteh Dadfarnia, Dariush Saberi
A highly selective and sensitive colorimetric sensor for the determination of naproxen (NAP) based on the aggregation of the thiolated β-cyclodextrin (Tβ-CD) functionalized gold nanoparticles (Tβ-CD-Au NPs) in the presence of NAP and Zn(2+)is described. The hydrophobic end of NAP interacts with the immobilized Tβ-CD on the Au NPs and forms the complex of Tβ-CD:NAP while the Zn(2+) ions form a 1:2 complex of (NAP)2Zn with the carboxyl groups of NAP resulting in the aggregation of functionalized gold nanoparticles...
February 8, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
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