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https://www.readbyqxmd.com/read/28938582/effect-of-hepatic-steatosis-on-the-progression-of-chronic-hepatitis-b-a-prospective-cohort-and-in-vitro-study
#1
Yangqin Chen, Chunlei Fan, Yuhan Chen, Hui Liu, Shanshan Wang, Peiling Dong, Lei Li, Huiguo Ding
AIM: To characterize the effect of hepatic steatosis (HS) on the progression of chronic hepatitis B. METHODS: A total of 162 chronic hepatitis B (CHB) patients confirmed by liver biopsy were involved in this study. All subjects were prospectively followed-up for 5 years in real-life clinical practice. Fibrosis stage was determined using aspartate aminotransferase-to-platelet ratio index (APRI). The end-point was cirrhosis, liver cancer or death. The effects of steatosis on the biological behavior of hepatocellular carcinoma cells were investigated using oleic acid-induced lipid accumulation in HepG2, HLE, PLC, and SMMC-7721 cells...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938489/prognostic-classifier-based-on-genome-wide-dna-methylation-profiling-in-well-differentiated-thyroid-tumors
#2
Mariana Bisarro Dos Reis, Mateus Camargo Barros-Filho, Fábio Albuquerque Marchi, Caroline Moraes Beltrami, Hellen Kuasne, Clóvis Antônio Lopes Pinto, Srikant Ambatipudi, Zdenko Herceg, Luiz Paulo Kowalski, Silvia Regina Rogatto
Context: Even though the majority of well-differentiated thyroid cancer (WDTC) is indolent, a number of cases display an aggressive behavior. Cumulative evidences have suggested that the deregulation of DNA methylation has the potential to point out molecular markers associated with worse prognosis. Objective: To identify a prognostic epigenetic signature in thyroid cancer. Design: Genome-wide DNA methylation assays (450k platform, Illumina) were performed in a cohort of 50 non-neoplastic thyroid tissues (NT), 17 benign thyroid lesions (BTL) and 74 thyroid carcinomas (60 papillary, 8 follicular, 2 Hürthle cell, 1 poorly differentiated and 3 anaplastic)...
August 16, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938250/listening-effort-how-the-cognitive-consequences-of-acoustic-challenge-are-reflected-in-brain-and-behavior
#3
Jonathan E Peelle
Everyday conversation frequently includes challenges to the clarity of the acoustic speech signal, including hearing impairment, background noise, and foreign accents. Although an obvious problem is the increased risk of making word identification errors, extracting meaning from a degraded acoustic signal is also cognitively demanding, which contributes to increased listening effort. The concepts of cognitive demand and listening effort are critical in understanding the challenges listeners face in comprehension, which are not fully predicted by audiometric measures...
September 21, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28938227/do-prereaders-auditory-processing-and-speech-perception-predict-later-literacy
#4
Sophie Vanvooren, Hanne Poelmans, Astrid De Vos, Pol Ghesquière, Jan Wouters
Developmental dyslexia has frequently been linked to deficits in auditory processing and speech perception. However, the presence and precise nature of these deficits and the direction of their relation with reading, remains debated. In this longitudinal study, 87 five-year-olds at high and low family risk for dyslexia were followed before and during different stages of reading acquisition. The processing of different auditory cues was investigated, together with performance on speech perception and phonology and reading...
September 19, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28938207/zinc-oxide-nanoparticles-in-predicted-environmentally-relevant-concentrations-leading-to-behavioral-impairments-in-male-swiss-mice
#5
Joyce Moreira de Souza, Bruna de Oliveira Mendes, Abraão Tiago Batista Guimarães, Aline Sueli de Lima Rodrigues, Thales Quintão Chagas, Thiago Lopes Rocha, Guilherme Malafaia
Although the potential neurotoxic effects from the exposure to zinc oxide nanoparticles (ZnO NPs) on humans and on experimental models have been reported in previous studies, the effects from the exposure to environmentally relevant concentrations of them remain unclear. Thus, the aim of the present study is to investigate the effects from the exposure to environmentally relevant concentrations of ZnO NPs on the behavior of male Swiss mice. The animals were daily exposed to environmentally relevant concentrations of ZnO NPs (5...
September 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28937953/the-biological-basis-of-chronic-traumatic-encephalopathy-following-blast-injury-a-literature-review
#6
Matt Aldag, Regina C Armstrong, Faris Bandak, Patrick S F Bellgowan, Timothy Bentley, Sean Biggerstaff, Katrina Caravelli, Joan Cmarik, Alicia Crowder, Thomas J DeGraba, Travis A Dittmer, Richard G Ellenbogen, Colin Greene, Raj K Gupta, Ramona Hicks, Stuart Hoffman, Robert C Latta, Michael J Leggieri, Donald Marion, Robert Mazzoli, Michael McCrea, John O'Donnell, Mark Packer, James B Petro, Todd E Rasmussen, Wendy Sammons-Jackson, Richard Shoge, Victoria Tepe, Ladd A Tremaine, James Zheng
The United States Department of Defense Blast Injury Research Program Coordinating Office organized the 2015 International State-of-the-Science meeting to explore links between blast-related head injury and the development of chronic traumatic encephalopathy (CTE). Before the meeting, the planning committee examined articles published between 2005 and October 2015 and prepared this literature review, which summarized broadly CTE research and addressed questions about the pathophysiological basis of CTE and its relationship to blast- and nonblast-related head injury...
September 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28937937/self-compassion-and-suicidal-behavior-in-college-students-serial-indirect-effects-via-depression-and-wellness-behaviors
#7
Jessica Kelliher Rabon, Fuschia M Sirois, Jameson K Hirsch
OBJECTIVE: College students may be at heightened risk for suicide and suicidal behavior due to maladaptive cognitive-emotional factors and failure to practice basic health behaviors. However, self-compassion and wellness behaviors may protect against risk. The relation between self-compassion and suicidal behavior and the contributing roles of depressive symptoms and wellness behaviors was examined. PARTICIPANTS: Participants were 365 undergraduate students. Data was collected in April 2015...
September 22, 2017: Journal of American College Health: J of ACH
https://www.readbyqxmd.com/read/28937932/health-and-safety-in-organic-farming-a-qualitative-study
#8
Francisco Soto Mas, Alexis J Handal, Rose E Rohrer, Eric Tomalá Viteri
OBJECTIVE: To explore health and safety issues in organic farming, specifically among small farmers in central New Mexico. METHODS: Participants included 10 certified organic producers and 20 workers. Data were collected through semi-structured interviews and observations. RESULTS: The sample consisted of a young, educated, low experienced population which may differ from conventional farmers. Both producers and workers seemed to be aware of the health risks involved with small-scale farming...
September 22, 2017: Journal of Agromedicine
https://www.readbyqxmd.com/read/28937923/psychological-factors-in-chronic-edema-a-case-control-study
#9
Christine J Moffatt, Aimee Aubeeluck, Peter J Franks, Debra C Doherty, Peter Mortimer, Isabelle Quere
BACKGROUND: To examine psychological health and perceived social support in patients with chronic edema (CE). METHODS AND RESULTS: A random sample of 107 patients with CE was group matched for age and gender with 102 community controls. The cases had swelling of the arm (38%) and leg (61%) and midline swelling (14%). Cases were more likely to be single or divorced/separated (p = 0.041) and have reduced mobility (p < 0.001). They had significantly poorer overall health related quality of life (HRQoL), in particular physical functioning (p = 0...
September 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28937921/internalizing-risk-factors-for-college-students-alcohol-use-a-combined-person-and-variable-centered-approach
#10
Stephanie E Wemm, Stephanie M Ernestus, Cathryn Glanton Holzhauer, Renata Vaysman, Edelgard Wulfert, Allen C Israel
BACKGROUND: Most studies that investigate internalizing problems (i.e., depression and anxiety symptoms) and alcohol use disorders use variable-centered approaches, losing important information about differences among individuals. OBJECTIVES: To group college students by different profiles of alcohol-use risk factors using a person-centered cluster analysis in two separate samples. METHODS: Questionnaires were used in both studies to assess positive expectancies regarding alcohol use, coping motives for alcohol use, and symptoms of depression and anxiety...
September 22, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28937874/can-a-label-help-me-drink-in-moderation-a-review-of-the-evidence-on-standard-drink-labelling
#11
Ashley Wettlaufer
INTRODUCTION: Understanding the concept of a standard drink (SD) is foundational knowledge to many public health policies aimed at reducing alcohol-related harms. These policies include adhering to low-risk drinking guidelines, screening brief intervention and referral activities, and counter alcohol-impaired driving initiatives. A lack of awareness of SDs might preclude the effectiveness of these interventions. A systematic review was conducted to review the evidence about how effective alcohol labels are in communicating SD information to the consumer...
September 22, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28937863/bullying-victimization-binge-drinking-and-marijuana-use-among-adolescents-results-from-the-2013-national-youth-risk-behavior-survey
#12
Emily Priesman, Rameika Newman, Jason A Ford
The current research examines the association between bullying victimization, binge drinking, and marijuana use among adolescents. We seek to determine if this association varies based on the type of bullying experienced, traditional or cyberbullying. We used data from the 2013 Youth Risk Behavior Survey, a nationally representative sample of high school students in the United States. The dependent variables were binge drinking and marijuana use. Our key independent variable, bullying victimization, included both traditional and cyberbullying...
September 22, 2017: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/28937691/toward-a-conceptual-framework-for-early-brain-and-behavior-development-in-autism
#13
J Piven, J T Elison, M J Zylka
Studies of infant siblings of older autistic probands, who are at elevated risk for autism, have demonstrated that the defining features of autism are not present in the first year of life but emerge late in the first and into the second year. A recent longitudinal neuroimaging study of high-risk siblings revealed a specific pattern of brain development in infants later diagnosed with autism, characterized by cortical surface area hyper-expansion in the first year followed by brain volume overgrowth in the second year that is associated with the emergence of autistic social deficits...
October 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28937451/cognitive-and-psychosocial-functioning-of-preschool-aged-children-with-cancer
#14
Victoria W Willard, Lauren E Cox, Kathryn M Russell, Ansley Kenney, Niki Jurbergs, Andrew E Molnar, Jennifer L Harman
OBJECTIVE: Most children with cancer are diagnosed in early childhood, potentially resulting in missed developmental opportunities. The most common diagnoses-brain tumors, leukemia-are also associated with increased risk of neurocognitive deficits. Unfortunately, research regarding the functioning of preschool-aged children with cancer is limited. Our objective is to describe the cognitive and psychosocial functioning of preschool-aged children with cancer who completed a clinical evaluation at a hospital-based psychology clinic...
September 19, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28937337/ethical-and-legal-implications-of-the-methodological-crisis-in-neuroimaging
#15
Philipp Kellmeyer
Currently, many scientific fields such as psychology or biomedicine face a methodological crisis concerning the reproducibility, replicability, and validity of their research. In neuroimaging, similar methodological concerns have taken hold of the field, and researchers are working frantically toward finding solutions for the methodological problems specific to neuroimaging. This article examines some ethical and legal implications of this methodological crisis in neuroimaging. With respect to ethical challenges, the article discusses the impact of flawed methods in neuroimaging research in cognitive and clinical neuroscience, particularly with respect to faulty brain-based models of human cognition, behavior, and personality...
October 2017: Cambridge Quarterly of Healthcare Ethics: CQ: the International Journal of Healthcare Ethics Committees
https://www.readbyqxmd.com/read/28936815/-current-clinical-variables-in-schizophrenia-cases-with-suicide-attempt-history
#16
Demet Sağlam Aykut, Filiz Civil Arslan, Evrim Özkorumak Karagüzel, Serdar Karakullukçu, Ahmet Tiryaki
OBJECTIVE: High suicide risk was shown to be related with depression and low quality of life in studies investigating clinical variables related to suicidal behavior. The aim of this study was to investigate the effects of a suicide attempt on clinical presentation by comparing sociodemographic variables, clinical signs, symptoms of depression, quality of life, social functionality, and reported adverse drug reactions in schizophrenic patients with and without suicide. METHOD: Positive and Negative Syndrome Scale (PANSS), Calgary Depression Scale (CDS), Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q), Social Functioning Scale (SFS), and Udvalg for Kliniske Undersøgelser Side Effect Rating Scale (UKU) were administered to 115 patients with schizophrenia...
2017: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/28936797/peer-victimization-and-adjustment-in-young-adulthood-introduction-to-the-special-section
#17
Mara Brendgen
A substantive number of children and adolescents are bullied by their peers, with serious risks for the victims' emotional, behavioral, physical, and academic adjustment. However, while the immediate and short-term consequences of peer victimization in childhood and adolescence are very well documented, knowledge about the potential long-term consequences for victims' functioning once they reach adulthood is only slowly emerging. Based on prospective, longitudinal data from different countries, the 4 papers in this special section investigate the association between peer victimization suffered in childhood and adolescence and victims' developmental outcomes in late adolescence/early adulthood...
September 22, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28936644/and-she-s-buying-a-stairway-to-health-signs-and-participant-factors-influencing-stair-ascent-at-a-public-airport
#18
John Bellettiere, Sandy Liles, Yael BenPorat, Natasha Bliss, Suzanne C Hughes, Brent Bishop, Kristi Robusto, Melbourne F Hovell
Several studies have demonstrated that point-of-choice prompts modestly increase stair use (i.e., incidental physical activity) in many public places, but evidence of effectiveness in airport settings is weak. Furthermore, evaluating the effects of past physical activity on stair use and on point-of-choice prompts to increase stair use is lacking. The purpose of this study was to evaluate the influence of sign prompts and participant factors including past physical activity on stair ascent in an airport setting...
September 21, 2017: Journal of Primary Prevention
https://www.readbyqxmd.com/read/28936640/autism-spectrum-disorder-and-school-bullying-who-is-the-victim-who-is-the-perpetrator
#19
Soonjo Hwang, Young Shin Kim, Yun-Joo Koh, Bennett L Leventhal
While a growing number of studies indicate associations between experiences of bullying and autism spectrum disorder (ASD), it is not clear what roles comorbid behavioral problems may play. We investigated the experiences of children with ASD as victims and/or perpetrators of bullying. Children with ASD epidemiologically ascertained participated in a cross-sectional study. Although children with ASD showed significantly increased risk for bullying involvement compared to community children, after controlling for comorbid psychopathology and other demographic factors, increased risks for being perpetrators or victim-perpetrators disappeared while risk for being bullied/teased continued to be significantly elevated...
September 21, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28936622/prevalence-of-psychopathology-in-bipolar-high-risk-offspring-and-siblings-a-meta-analysis
#20
REVIEW
Phoebe Lau, David J Hawes, Caroline Hunt, Andrew Frankland, Gloria Roberts, Philip B Mitchell
This meta-analysis aimed to update existing data on the comparison of prevalence rates of psychopathology primarily among offspring with at least one parent with bipolar disorder (BD) and offspring of parents without psychiatric illness. Seventeen studies were derived from a systematic search of PsychInfo, Medline, Scopus and Embase. Inclusion criteria were use of a control offspring group, standardized diagnostic procedures and reporting of clear frequency data. Risk of psychopathology was estimated by aggregating frequency data from selected studies...
September 21, 2017: European Child & Adolescent Psychiatry
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