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https://www.readbyqxmd.com/read/28937498/constrictive-calcific-pericarditis-in-a-scleroderma-patient
#1
Queen Okereke, Steve Sutcliffe, Josh Hanson
No abstract text is available yet for this article.
September 21, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28937476/constrictive-calcific-pericarditis-in-a-scleroderma-patient
#2
Queen Okereke, Steve Sutcliffe, Josh Hanson
No abstract text is available yet for this article.
October 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28935460/myocardial-fibrosis-detected-by-magnetic-resonance-in-systemic-sclerosis-patients-relationship-with-biochemical-and-echocardiography-parameters
#3
Milan Hromádka, Jitka Seidlerová, David Suchý, Daniel Rajdl, Jan Lhotský, Jaroslav Ludvík, Richard Rokyta, Jan Baxa
OBJECTIVES: Systemic scleroderma (SSc) is a rare connective tissue disease presenting with fibrosis affecting skin and internal organs. Cardiovascular magnetic resonance (CMR) with quantification of extracellular volume (ECV) and T1 mapping might help to detect heart involvement. We aimed to evaluate whether myocardial involvement correlates with functional and laboratory parameters. METHODS: Thirty-three asymptomatic SSc patients (29 women, aged 56.6±12.2years) and 20 controls (10 women, 53...
September 18, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28933138/assessment-of-treatment-effects-on-digital-ulcer-and-blood-perfusion-by-laser-speckle-contrast-analysis-in-a-patient-affected-by-systemic-sclerosis
#4
B Ruaro, S Paolino, C Pizzorni, M Cutolo, A Sulli
Laser speckle contrast analysis (LASCA) is a good tool to evaluate the variation in peripheral blood perfusion during long-term follow-up and is able to safely monitor digital ulcer evolution in scleroderma patients. It evaluates blood perfusion in different areas within the skin lesions and surrounding them during standard treatment.
September 21, 2017: Reumatismo
https://www.readbyqxmd.com/read/28927315/systematic-review-and-meta-analysis-of-the-epidemiology-of-polyautoimmunity-in-sj%C3%A3-gren-s-syndrome-secondary-sj%C3%A3-gren-s-syndrome-focusing-on-autoimmune-rheumatic-diseases
#5
H Alani, J R Henty, N L Thompson, E Jury, C Ciurtin
OBJECTIVE: The epidemiology of polyautoimmunity in Sjögren's syndrome (secondary Sjögren's syndrome - sSS) is not well defined and has not been investigated before using a systematic approach. We conducted a systematic review of the epidemiology of sSS associated with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), scleroderma, and myositis, assessing the prevalence rates (PRs) and clinical and serological features of sSS. METHOD: A systematic literature search of PubMed and Embase databases (updated to March 2016) was performed to identify all published data on PR, demographic profile, clinical manifestations, laboratory features, and causes of death associated with sSS...
September 20, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28917997/lung-transplantation-for-scleroderma-strength-in-numbers
#6
EDITORIAL
Allan C Gelber
No abstract text is available yet for this article.
September 13, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28916993/periostin-in-the-pathogenesis-of-skin-diseases
#7
REVIEW
Hiroyuki Murota, Yang Lingli, Ichiro Katayama
Skin is an organ that is susceptible to damage by external injury, chronic inflammation, and autoimmunity. Tissue damage causes alterations in both the configuration and type of cells in lesional skin. This phenomenon, called tissue remodeling, is a universal biological response elicited by programmed cell death, inflammation, immune disorders, and tumorigenic, tumor proliferative, and cytoreductive activity. In this process, changes in the components of the extracellular matrix are required to provide an environment that facilitates tissue remodeling...
September 15, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28913656/new-insights-into-cardiac-involvement-in-juvenile-scleroderma-a-three-dimensional-echocardiographic-assessment-unveils-subclinical-ventricle-dysfunction
#8
Reyhan Dedeoglu, Amra Adroviç, Funda Oztunç, Sezgin Sahin, Kenan Barut, Ozgur Kasapcopur
Cardiac manifestations in juvenile scleroderma or systemic sclerosis (JSSc) have poor prognosis, begin in early stages of the disease, and remain clinically asymptomatic. New echocardiography modalities, such as 2D/3D speckle tracking (STE, strain analysis for regional and global ventricular functions), can detect cardiac involvement in early stages. We assessed 21 JSSc patients and 19 controls using 2D/3D STE. The left ventricular end diastolic volume, end systolic volume, and ejection fraction of the patient and control groups were significantly different (99...
September 14, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28912623/measurement-of-serum-klotho-in-systemic-sclerosis
#9
Rossella Talotta, Sara Bongiovanni, Teresa Letizia, Federica Rigamonti, Maria Chiara Ditto, Fabiola Atzeni, Fausto Salaffi, Alberto Batticciotto, Maria Chiara Gerardi, Marco Antivalle, Tarcisio Vago, Maurizio Benucci, Piercarlo Sarzi-Puttini
BACKGROUND: The aim of our study was to evaluate the serum concentration of klotho in a cohort of systemic sclerosis (SSc) patients compared to that of healthy controls and to correlate its levels with the degree and the kind of organ involvement. METHODS: Blood samples obtained from both patients and controls were collected and analysed by an ELISA test for the determination of human soluble klotho. Scleroderma patients were evaluated for disease activity through clinical, laboratory, and instrumental assessment...
2017: Disease Markers
https://www.readbyqxmd.com/read/28899803/humanistic-and-cost-burden-of-systemic-sclerosis-a-review-of-the-literature
#10
REVIEW
Aryeh Fischer, Evelina Zimovetz, Caroline Ling, Dirk Esser, Nils Schoof
BACKGROUND: Systemic sclerosis (SSc), or systemic scleroderma, is a chronic multisystem autoimmune disease characterised by widespread vascular injury and progressive fibrosis of the skin and internal organs. Patients with SSc have decreased survival, with pulmonary involvement as the main cause of death. Current treatments for SSc manage a range of symptoms but not the cause of the disease. Our review describes the humanistic and cost burden of SSc. METHODS: A structured review of the literature was conducted, using predefined search strategies to search PubMed, Embase, and the Cochrane Library...
September 9, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28894946/an-international-survey-on-non-invasive-techniques-to-assess-the-microcirculation-in-patients-with-raynaud-s-phenomenon-sunshine-survey
#11
Francesca Ingegnoli, Nicola Ughi, Graham Dinsdale, Annalisa Orenti, Patrizia Boracchi, Yannick Allanore, Ivan Foeldvari, Alberto Sulli, Maurizio Cutolo, Vanessa Smith, Ariane L Herrick
To canvas opinion concerning the role of non-invasive techniques in the assessment of patients with Raynaud's phenomenon (Rp) in clinical and research settings: four nailfold capillaroscopy methods [videocapillaroscopy (NVC), dermoscopy, stereomicroscopy, digital USB microscopy], four laser Doppler methods (laser Doppler flowmetry, imaging, anemometry/velocimetry, laser speckle contrast analysis), thermographic imaging, and upper limb arterial Doppler ultrasound. Emails with a link to the survey were sent to physicians from the European Scleroderma Trials and Research group (EUSTAR), the EULAR Study Group on Microcirculation in Rheumatic Diseases (SG_MC/RD) and members of the pediatric rheumatology Email board...
September 11, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28888414/use-of-silver-diamine-fluoride-for-the-maintenance-of-dental-prostheses-in-a-high-caries-risk-patient-a-medical-management-approach
#12
Lola Giusti, Cathrine Steinborn, Maya Steinborn
A technique for using silver diamine fluoride (SDF) as part of a regimen to help maintain dental prostheses in a patient with scleroderma and at high risk of caries is presented. Medically compromised, xerostomic, or elderly patients generally face greater risk of caries and specifically with prosthetic retainer teeth. SDF is a minimally invasive solution to this problem. A technique is described for using SDF to arrest and prevent new caries with the goal of maintaining fixed and removable prostheses and supporting teeth in a cost-effective manner...
September 6, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28887633/periostin-in-inflammation-and-allergy
#13
REVIEW
Kenji Izuhara, Satoshi Nunomura, Yasuhiro Nanri, Masahiro Ogawa, Junya Ono, Yasutaka Mitamura, Tomohito Yoshihara
We found for the first time that IL-4 and IL-13, signature type 2 cytokines, are able to induce periostin expression. We and others have subsequently shown that periostin is highly expressed in chronic inflammatory diseases-asthma, atopic dermatitis, eosinophilc chronic sinusitis/chronic rhinosinusitis with nasal polyp, and allergic conjunctivitis-and that periostin plays important roles in the pathogenesis of these diseases. The epithelial/mesenchymal interaction via periostin is important for the onset of allergic inflammation, in which periostin derived from fibroblasts acts on epithelial cells or fibroblasts, activating their NF-κB...
September 8, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28885215/hyperspectral-imaging-as-a-novel-diagnostic-tool-in-microcirculation-of-wounds
#14
Georg Daeschlein, Inga Langner, Thomas Wild, Sebastian von Podewils, Claudia Sicher, Thomas Kiefer, Michael Jünger
Monitoring of perfusion is a cornerstone in surgery, phlebology and basic science to proof wound healing by interventions. In chronic wound management it is of utmost importance to realize and parametrize wound bed perfusion to verify actual, and plan further treatment by noninvasive diagnostics. Up to now monitoring is based on visual inspection of wounds as conventionally practiced over more than decades. The main problems of visual inspection are the lack of standardization and comparability because of interindividual variations...
September 4, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28884475/chronic-exposure-of-interleukin-13-suppress-the-induction-of-matrix-metalloproteinase-1-by-tumor-necrosis-factor-%C3%AE-in-normal-and-scleroderma-dermal-fibroblasts-through-protein-kinase-b-akt
#15
Monica L Brown Lobbins, Bangalore R Shivakumar, Arnold E Postlethwaite, Karen A Hasty
OBJECTIVE: Peripheral blood mononuclear cells taken from patients with scleroderma express increased levels of IL-13. Moreover, the expression of MMP-1 from involved scleroderma skin fibroblasts is refractory to stimulation by tumor necrosis factor alpha. To elucidate the mechanism(s) involved, we examined the effect of IL-13 on TNF-α-induced matrix metalloproteinase-1 expression in normal and scleroderma human dermal fibroblast lines and studied the involvement of serine/threonine kinase B/Akt in this response...
September 7, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28872977/growth-differentiation-factor-15-gdf-15-level-and-relation-to-clinical-manifestations-in-egyptian-systemic-sclerosis-patients-preliminary-data
#16
Sherif M Gamal, Fatema T Elgengehy, Asmaa Kamal, Samah A El Bakry, Elham Shabaan, Aliaa Elgendy, Iman H Bassyouni
AIM OF THE WORK: This study aims to assess Growth differentiation factor-15 (GDF-15) level in Scleroderma patients and its relation to disease manifestations. PATIENTS AND METHODS: This study included 55 scleroderma patients and 40 age and sex matched healthy volunteers. All patients were subjected to full history taking, thorough clinical examination, and laboratory investigations. GDF-15 serum levels were analyzed in patients and controls using human GDF-15 immunoassay Quantikine ELISA kit...
October 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28870693/therapeutic-targeting-of-taz-and-yap-by-dimethyl-fumarate-in-systemic-sclerosis-fibrosis
#17
Tetsuo Toyama, Agnieszka P Looney, Brendon M Baker, Lukasz Stawski, Paul Haines, Robert Simms, Aleksander D Szymaniak, Xaralabos Varelas, Maria Trojanowska
Systemic sclerosis (scleroderma, SSc) is a devastating fibrotic disease with few treatment options. Fumaric acid esters, including dimethyl fumarate (DMF, Tecfidera®) have shown therapeutic effects in several disease models, prompting us to determine whether DMF is effective as a treatment for SSc dermal fibrosis. We found that DMF blocks the pro-fibrotic effects of TGFβ in SSc skin fibroblasts. Mechanistically, we found that DMF treatment reduced nuclear localization of TAZ and YAP proteins via inhibition of PI3-K/Akt1 pathway...
September 1, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28870043/-research-of-systemic-sclerosis-sine-scleroderma
#18
G Z Zhang, H B Li
No abstract text is available yet for this article.
September 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/28869415/a-novel-iloprost-administration-method-with-portable-syringe-pump-for-the-treatment-of-acral-ulcers-and-raynaud-s-phenomenon-in-systemic-sclerosis-patients-a-pilot-study-iloporta
#19
Paolo Fraticelli, Giuseppe Pio Martino, Marta Murri, Massimo Mattioli, Armando Gabrielli
OBJECTIVES: The objective of the study is to evaluate the feasibility, safety and efficacy of home infusion of iloprost with the new portable syringe pump Infonde®, for the treatment of scleroderma-related Raynaud's phenomenon and digital ulcers. METHODS: 12 scleroderma patients were treated with iloprost at home, using the pump, with infusion cycles of 2 days per month (24 hours a day), for 6 months. RESULTS: The home treatment proved feasible since ten patients (83%) completed the entire infusion cycle, thus satisfying the feasibility target imposed by the protocol (75%)...
August 31, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28869413/severe-oesophageal-disease-and-its-associations-with-systemic-sclerosis
#20
Georgios P Karamanolis, Konstantinos Denaxas, Stylianos Panopoulos, Kalliopi-Vasiliki Bournia, Alexandra Zorbala, Dimitrios Kamberoglou, Dimitrios Schizas, Spiros D Ladas, Petros P Sfikakis
OBJECTIVES: Severe oesophageal disease in patients with systemic sclerosis (SSc), referred as scleroderma oesophagus, is characterised by ineffective or absent peristalsis along with hypotensive oesophagogastric junction (hEGJ). The associations between scleroderma oesophagus and different clinical and laboratory manifestations of SSc is still controversial. In this study we aimed to assess associations between scleroderma oesophagus, diagnosed by high resolution manometry (HRM), and other manifestations of disease...
August 30, 2017: Clinical and Experimental Rheumatology
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