keyword
MENU ▼
Read by QxMD icon Read
search

mouse motor cortex

keyword
https://www.readbyqxmd.com/read/29458197/changes-in-motor-function-cognition-and-emotion-related-behavior-after-right-hemispheric-intracerebral-hemorrhage-in-various-brain-regions-of-mouse
#1
Wei Zhu, Yufeng Gao, Jieru Wan, Xi Lan, Xiaoning Han, Shanshan Zhu, Weidong Zang, Xuemei Chen, Wendy Ziai, Daniel F Hanley, Scott J Russo, Ricardo E Jorge, Jian Wang
Intracerebral hemorrhage (ICH) is a detrimental type of stroke. Mouse models of ICH, induced by collagenase or blood infusion, commonly target striatum, but not other brain sites such as ventricular system, cortex, and hippocampus. Few studies have systemically investigated brain damage and neurobehavioral deficits that develop in animal models of ICH in these areas of the right hemisphere. Therefore, we evaluated the brain damage and neurobehavioral dysfunction associated with right hemispheric ICH in ventricle, cortex, hippocampus, and striatum...
February 16, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29456186/neurons-generated-by-mouse-escs-with-hippocampal-or-cortical-identity-display-distinct-projection-patterns-when-co-transplanted-in-the-adult-brain
#2
Marco Terrigno, Irene Busti, Claudia Alia, Marta Pietrasanta, Ivan Arisi, Mara D'Onofrio, Matteo Caleo, Federico Cremisi
The capability of generating neural precursor cells with distinct types of regional identity in vitro has recently opened new opportunities for cell replacement in animal models of neurodegenerative diseases. By manipulating Wnt and BMP signaling, we steered the differentiation of mouse embryonic stem cells (ESCs) toward isocortical or hippocampal molecular identity. These two types of cells showed different degrees of axonal outgrowth and targeted different regions when co-transplanted in healthy or lesioned isocortex or in hippocampus...
February 8, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29455576/central-infusion-of-igf-1-increases-hippocampal-neurogenesis-and-improves-neurobehavioral-function-following-traumatic-brain-injury
#3
Shaun W Carlson, Kathryn E Saatman
Traumatic brain injury (TBI) produces neuronal dysfunction and cellular loss that can culminate in lasting impairments in cognitive and motor abilities. Therapeutic agents that promote repair and replenish neurons after TBI hold promise in improving recovery of function. Insulin-like growth factor-1 (IGF-1) is a neurotrophic factor capable of mediating neuroprotective and neuroplasticity mechanisms. Targeted overexpression of IGF-1 enhances the generation of hippocampal newborn neurons in brain-injured mice; however, the translational neurogenic potential of exogenously administered IGF-1 after TBI remains unknown...
February 17, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29449528/als-related-human-cortical-and-motor-neurons-survival-is-differentially-affected-by-sema3a
#4
Anastasya Birger, Miri Ottolenghi, Liat Perez, Benjamin Reubinoff, Oded Behar
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by cell death of upper and lower motor neurons (MNs). The cause of MN cell loss is not completely understood but involves both cell autonomous and non-cell autonomous mechanisms. Numerous molecules have been implicated to be involved in the death of MNs. One such candidate is semaphorin 3A (Sema3A). In ALS patients, Sema3A was shown to be significantly upregulated in the motor cortex and downregulated in the spinal cord. In the mouse, Sema3A was shown to be an axon repellent molecule for MNs...
February 15, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29432412/hub-connectivity-neuronal-diversity-and-gene-expression-in-the-caenorhabditis-elegans-connectome
#5
Aurina Arnatkevic Iūtė, Ben D Fulcher, Roger Pocock, Alex Fornito
Studies of nervous system connectivity, in a wide variety of species and at different scales of resolution, have identified several highly conserved motifs of network organization. One such motif is a heterogeneous distribution of connectivity across neural elements, such that some elements act as highly connected and functionally important network hubs. These brain network hubs are also densely interconnected, forming a so-called rich club. Recent work in mouse has identified a distinctive transcriptional signature of neural hubs, characterized by tightly coupled expression of oxidative metabolism genes, with similar genes characterizing macroscale inter-modular hub regions of the human cortex...
February 12, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29431654/enhanced-operant-extinction-and-prefrontal-excitability-in-a-mouse-model-of-angelman-syndrome
#6
Michael S Sidorov, Matthew C Judson, Hyojin Kim, Marie Rougie, Alejandra I Ferrer, Viktoriya D Nikolova, Natallia V Riddick, Sheryl S Moy, Benjamin D Philpot
Angelman syndrome (AS), a neurodevelopmental disorder associated with intellectual disability, is caused by loss of maternal allele expression of UBE3A in neurons. Mouse models of AS faithfully recapitulate disease phenotypes across multiple domains, including behavior. Yet in AS, there has been only limited study of behaviors encoded by the prefrontal cortex, a region broadly involved in executive function and cognition. Because cognitive impairment is a core feature of AS, it is critical to develop behavioral readouts of prefrontal circuit function in AS mouse models...
February 5, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29415125/elongator-subunit-3-elp3-modifies-als-through-trna-modification
#7
Andre Bento-Abreu, Gunilla Jager, Bart Swinnen, Laura Rué, Stijn Hendrickx, Ashley Jones, Kim A Staats, Ines Taes, Caroline Eykens, Annelies Nonneman, Rik Nuyts, Mieke Timmers, Lara Silva, Alain Chariot, Laurent Nguyen, John Ravits, Robin Lemmens, Deirdre Cabooter, Van Den Bosch Ludo, Philip Van Damme, Ammar Al-Chalabi, Anders Bystrom, Wim Robberecht
Amyotrophic Lateral Sclerosis (ALS) is a fatal degenerative motor neuron disorder of which the progression is influenced by several disease-modifying factors. Here, we investigated ELP3, a subunit of the elongator complex that modifies tRNA wobble uridines, as one of such ALS disease modifiers. ELP3 attenuated the axonopathy of a mutant SOD1, as well as of a mutant C9orf72 ALS zebrafish model. Furthermore, expression of ELP3 in the SOD1G93A mouse extended the survival and attenuated the denervation in this model...
February 3, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29400109/evolution-of-the-neurochemical-profiles-in-the-g93a-sod1-mouse-model-of-amyotrophic-lateral-sclerosis
#8
Hongxia Lei, Elisabeth Dirren, Carole Poitry-Yamate, Bernard L Schneider, Rolf Gruetter, Patrick Aebischer
In vivo 1H magnetic resonance spectroscopy (1H-MRS) investigations of amyotrophic lateral sclerosis (ALS) mouse brain may provide neurochemical profiles and alterations in association with ALS disease progression. We aimed to longitudinally follow neurochemical evolutions of striatum, brainstem and motor cortex of mice transgenic for G93A mutant human superoxide dismutase type-1 (G93A-SOD1), an ALS model. Region-specific neurochemical alterations were detected in asymptomatic G93A-SOD1 mice, particularly in lactate (-19%) and glutamate (+8%) of brainstem, along with γ-amino-butyric acid (-30%), N-acetyl-aspartate (-5%) and ascorbate (+51%) of motor cortex...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29388323/effects-of-repeated-long-term-psychosocial-stress-and-acute-cannabinoid-exposure-on-mouse-corticostriatal-circuitries-implications-for-neuropsychiatric-disorders
#9
Jordi Tomas-Roig, Fabiana Piscitelli, Vanesa Gil, Ester Quintana, Lluís L Ramió-Torrentà, Jose Antonio Del Río, Timothy Patrick Moore, Hope Agbemenyah, Gabriela Salinas, Claudia Pommerenke, Stephan Lorenzen, Tim Beißbarth, Sigrid Hoyer-Fender, Vincenzo Di Marzo, Ursula Havemann-Reinecke
INTRODUCTION: Vulnerability to psychiatric manifestations is achieved by the influence of genetic and environment including stress and cannabis consumption. Here, we used a psychosocial stress model based on resident-intruder confrontations to study the brain corticostriatal-function, since deregulation of corticostriatal circuitries has been reported in many psychiatric disorders. CB1 receptors are widely expressed in the central nervous system and particularly, in both cortex and striatum brain structures...
January 31, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29379040/mri-of-the-cervical-spinal-cord-predicts-respiratory-dysfunction-in-als
#10
G Grolez, M Kyheng, R Lopes, C Moreau, K Timmerman, F Auger, G Kuchcinski, A Duhamel, P Jissendi-Tchofo, P Besson, C Laloux, M Petrault, J C Devedjian, Thierry Pérez, Pierre François Pradat, L Defebvre, R Bordet, V Danel-Brunaud, D Devos
For patients with amyotrophic lateral sclerosis (ALS), the primary therapeutic goal is to minimize morbidity. Non-invasive ventilation improves survival. We aim to assess whether Magnetic Resonance Imaging (MRI) of the cervical spinal cord predicts the progression of respiratory disorders in ALS. Brain and spinal MRI was repeatedly performed in the SOD1G86R mouse model, in 40 patients and in healthy controls. Atrophy, iron overload, white matter diffusivity and neuronal loss were assessed. In Superoxide Dismutase-1 (SOD1) mice, iron accumulation appeared in the cervical spinal cord at symptom onset but disappeared with disease progression (after the onset of atrophy)...
January 29, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29370870/diffusion-kurtosis-imaging-allows-the-early-detection-and-longitudinal-follow-up-of-amyloid-%C3%AE-induced-pathology
#11
Jelle Praet, Nikolay V Manyakov, Leacky Muchene, Zhenhua Mai, Vasilis Terzopoulos, Steve de Backer, An Torremans, Pieter-Jan Guns, Tom Van De Casteele, Astrid Bottelbergs, Bianca Van Broeck, Jan Sijbers, Dirk Smeets, Ziv Shkedy, Luc Bijnens, Darrel J Pemberton, Mark E Schmidt, Annemie Van der Linden, Marleen Verhoye
BACKGROUND: Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia in the elderly population. In this study, we used the APP/PS1 transgenic mouse model to explore the feasibility of using diffusion kurtosis imaging (DKI) as a tool for the early detection of microstructural changes in the brain due to amyloid-β (Aβ) plaque deposition. METHODS: We longitudinally acquired DKI data of wild-type (WT) and APP/PS1 mice at 2, 4, 6 and 8 months of age, after which these mice were sacrificed for histological examination...
January 9, 2018: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/29367009/changes-in-resting-state-functional-connectivity-after-stroke-in-a-mouse-brain-lacking-extracellular-matrix-components
#12
Miriana Jlenia Quattromani, Jakob Hakon, Uwe Rauch, Adam Q Bauer, Tadeusz Wieloch
In the brain, focal ischemia results in a local region of cell death and disruption of both local and remote functional neuronal networks. Tissue reorganization following stroke can be limited by factors such as extracellular matrix (ECM) molecules that prevent neuronal growth and synaptic plasticity. The brain's ECM plays a crucial role in network formation, development, and regeneration of the central nervous system. Further, the ECM is essential for proper white matter tract development and for the formation of structures called perineuronal nets (PNNs)...
January 20, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29352267/differential-susceptibility-of-striatal-hippocampal-and-cortical-neurons-to-caspase-6
#13
Anastasia Noël, Libin Zhou, Bénédicte Foveau, P Jesper Sjöström, Andréa C LeBlanc
Active cysteinyl protease Caspase-6 is associated with early Alzheimer and Huntington diseases. Higher entorhinal cortex and hippocampal Caspase-6 levels correlate with lower cognitive performance in aged humans. Caspase-6 induces axonal degeneration in human primary neuron cultures and causes inflammation and neurodegeneration in mouse hippocampus, and age-dependent memory impairment. To assess whether Caspase-6 causes damage to another neuronal system, a transgenic knock-in mouse overexpressing a self-activated form of Caspase-6 five-fold in the striatum, the area affected in Huntington disease, and 2...
January 19, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29346950/generalized-archimedes-principle-in-active-fluids
#14
Nitzan Razin, Raphael Voituriez, Jens Elgeti, Nir S Gov
We show how a gradient in the motility properties of noninteracting pointlike active particles can cause a pressure gradient that pushes a large inert object. We calculate the force on an object inside a system of active particles with position-dependent motion parameters, in one and two dimensions, and show that a modified Archimedes' principle is satisfied. We characterize the system, both in terms of the model parameters and in terms of experimentally measurable quantities: the spatial profiles of the density, velocity and pressure...
September 2017: Physical Review. E
https://www.readbyqxmd.com/read/29335072/rebound-excitability-mediates-motor-abnormalities-in-parkinson-s-disease
#15
Jeongjin Kim, Daesoo Kim
Parkinson's disease (PD) is a debilitating disorder resulting from loss of dopamine neurons. In dopamine deficient state, the basal ganglia increases inhibitory synaptic outputs to the thalamus. This increased inhibition by the basal ganglia output is known to reduce firing rate of thalamic neurons that relay motor signals to the motor cortex. This 'rate model' suggests that the reduced excitability of thalamic neurons is the key for inducing motor abnormalities in PD patients. We reveal that in response to inhibition, thalamic neurons generate rebound firing at the end of inhibition...
January 16, 2018: BMB Reports
https://www.readbyqxmd.com/read/29331264/altered-levels-of-the-splicing-factor-muscleblind-modifies-cerebral-cortical-function-in-mouse-models-of-myotonic-dystrophy
#16
Gang Chen, Russell E Carter, John D Cleary, Tammy S Reid, Laura P Ranum, Maurice S Swanson, Timothy J Ebner
Myotonic dystrophy (DM) is a progressive, multisystem disorder affecting skeletal muscle, heart, and central nervous system. In both DM1 and DM2, microsatellite expansions of CUG and CCUG RNA repeats, respectively, accumulate and disrupt functions of alternative splicing factors, including muscleblind (MBNL) proteins. Grey matter loss and white matter changes, including the corpus callosum, likely underlie cognitive and executive function deficits in DM patients. However, little is known how cerebral cortical circuitry changes in DM...
January 10, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29315537/vitamin-transporters-in-mice-brain-with-aging
#17
P Marcos, J González-Fuentes, L Castro-Vázquez, M V Lozano, M J Santander-Ortega, V Rodríguez-Robledo, N Villaseca-González, M M Arroyo-Jiménez
Its high metabolic rate and high polyunsaturated fatty acid content make the brain very sensitive to oxidative damage. In the brain, neuronal metabolism occurs at a very high rate and generates considerable amounts of reactive oxygen species and free radicals, which accumulate inside neurons, leading to altered cellular homeostasis and integrity and eventually irreversible damage and cell death. A misbalance in redox metabolism and the subsequent neurodegeneration increase throughout the course of normal aging, leading to several age-related changes in learning and memory as well as motor functions...
January 8, 2018: Journal of Anatomy
https://www.readbyqxmd.com/read/29287521/could-conservative-iron-chelation-lead-to-neuroprotection-in-amyotrophic-lateral-sclerosis
#18
Caroline Moreau, Véronique Danel, Jean Christophe Devedjian, Guillaume Grolez, Kelly Timmerman, Charlotte Laloux, Maud Petrault, Flore Gouel, Aurélie Jonneaux, Mary Dutheil, Cedrick Lachaud, Renaud Lopes, Gregory Kuchinski, Florent Auger, Maeva Kyheng, Alain Duhamel, Thierry Perez, Pierre-Francois Pradat, Helene Blasco, Charlotte Veyrat-Durebex, Philippe Corcia, Patrick Oeckl, Markus Otto, Luc Dupuis, Guillaume Garçon, Luc Defebvre, Ioav Zvi Cabantchik, James Duce, Régis Bordet, David Devos
Iron accumulation has been observed in mouse models and both sporadic and familial forms of Amyotrophic lateral sclerosis. Iron chelation could reduce iron accumulation and the related excess of oxidative stress in the motor pathways. However, classical iron chelation would induce systemic iron depletion. We assess the safety and efficacy of conservative iron chelation (i.e. chelation with low risk of iron depletion) in a murine preclinical model and pilot clinical trial. In Sod1G86R mice, deferiprone increased the mean life span as compared with placebo...
December 29, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29280732/combining-robotic-training-and-inactivation-of-the-healthy-hemisphere-restores-pre-stroke-motor-patterns-in-mice
#19
Cristina Spalletti, Claudia Alia, Stefano Lai, Alessandro Panarese, Sara Conti, Silvestro Micera, Matteo Caleo
Focal cortical stroke often leads to persistent motor deficits, prompting the need for more effective interventions. The efficacy of rehabilitation can be increased by 'plasticity-stimulating' treatments that enhance experience-dependent modifications in spared areas. Transcallosal pathways represent a promising therapeutic target, but their role in post-stroke recovery remains controversial. Here, we demonstrate that the contralesional cortex exerts an enhanced interhemispheric inhibition over the perilesional tissue after focal cortical stroke in mouse forelimb motor cortex...
December 27, 2017: ELife
https://www.readbyqxmd.com/read/29274742/effect-of-early-embryonic-deletion-of-huntingtin-from-pyramidal-neurons-on-the-development-and-long-term-survival-of-neurons-in-cerebral-cortex-and-striatum
#20
I Dragatsis, P Dietrich, H Ren, Y P Deng, N Del Mar, H B Wang, I M Johnson, K R Jones, A Reiner
We evaluated the impact of early embryonic deletion of huntingtin (htt) from pyramidal neurons on cortical development, cortical neuron survival and motor behavior, using a cre-loxP strategy to inactivate the mouse htt gene (Hdh) in emx1-expressing cell lineages. Western blot confirmed substantial htt reduction in cerebral cortex of these Emx-httKO mice, with residual cortical htt in all likelihood restricted to cortical interneurons of the subpallial lineage and/or vascular endothelial cells. Despite the loss of htt early in development, cortical lamination was normal, as revealed by layer-specific markers...
December 21, 2017: Neurobiology of Disease
keyword
keyword
18703
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"