keyword
https://read.qxmd.com/read/38399482/microvascular-capillary-and-precapillary-cardiovascular-disturbances-strongly-interact-to-severely-affect-tissue-perfusion-and-mitochondrial-function-in-myalgic-encephalomyelitis-chronic-fatigue-syndrome-evolving-from-the-post-covid-19-syndrome
#21
JOURNAL ARTICLE
Klaus Josef Wirth, Matthias Löhn
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a frequent, debilitating and still enigmatic disease. There is a broad overlap in the symptomatology of ME/CFS and the Post-COVID-19 Syndrome (PCS). A fraction of the PCS patients develop the full clinical picture of ME/CFS. New observations in microvessels and blood from patients suffering from PCS have appeared and include microclots and malformed pathological blood cells. Capillary blood flow is impaired not only by pathological blood components but also by prothrombotic changes in the vascular wall, endothelial dysfunction, and the expression of adhesion molecules in the capillaries...
January 23, 2024: Medicina
https://read.qxmd.com/read/38390594/dysautonomia-following-lyme-disease-a-key-component-of-post-treatment-lyme-disease-syndrome
#22
REVIEW
Brittany L Adler, Tae Chung, Peter C Rowe, John Aucott
Dysautonomia, or dysfunction of the autonomic nervous system (ANS), may occur following an infectious insult and can result in a variety of debilitating, widespread, and often poorly recognized symptoms. Dysautonomia is now widely accepted as a complication of COVID-19 and is an important component of Post-Acute Sequelae of COVID-19 (PASC or long COVID). PASC shares many overlapping clinical features with other infection-associated chronic illnesses including Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Post-Treatment Lyme Disease Syndrome (PTLDS), suggesting that they may share common underlying mechanisms including autonomic dysfunction...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38383493/fatigue-and-symptom-based-clusters-in-post-covid-19-patients-a-multicentre-prospective-observational-cohort-study
#23
MULTICENTER STUDY
Merel E B Cornelissen, Lizan D Bloemsma, Anouk W Vaes, Nadia Baalbaki, Qichen Deng, Rosanne J H C G Beijers, Lieke C E Noij, Laura Houweling, Somayeh Bazdar, Martijn A Spruit, Anke H Maitland-van der Zee
BACKGROUND: In the Netherlands, the prevalence of post COVID-19 condition is estimated at 12.7% at 90-150 days after SARS-CoV-2 infection. This study aimed to determine the occurrence of fatigue and other symptoms, to assess how many patients meet the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) criteria, to identify symptom-based clusters within the P4O2 COVID-19 cohort and to compare these clusters with clusters in a ME/CFS cohort. METHODS: In this multicentre, prospective, observational cohort in the Netherlands, 95 post COVID-19 patients aged 40-65 years were included...
February 21, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38383456/deep-phenotyping-of-post-infectious-myalgic-encephalomyelitis-chronic-fatigue-syndrome
#24
JOURNAL ARTICLE
Brian Walitt, Komudi Singh, Samuel R LaMunion, Mark Hallett, Steve Jacobson, Kong Chen, Yoshimi Enose-Akahata, Richard Apps, Jennifer J Barb, Patrick Bedard, Robert J Brychta, Ashura Williams Buckley, Peter D Burbelo, Brice Calco, Brianna Cathay, Li Chen, Snigdha Chigurupati, Jinguo Chen, Foo Cheung, Lisa M K Chin, Benjamin W Coleman, Amber B Courville, Madeleine S Deming, Bart Drinkard, Li Rebekah Feng, Luigi Ferrucci, Scott A Gabel, Angelique Gavin, David S Goldstein, Shahin Hassanzadeh, Sean C Horan, Silvina G Horovitz, Kory R Johnson, Anita Jones Govan, Kristine M Knutson, Joy D Kreskow, Mark Levin, Jonathan J Lyons, Nicholas Madian, Nasir Malik, Andrew L Mammen, John A McCulloch, Patrick M McGurrin, Joshua D Milner, Ruin Moaddel, Geoffrey A Mueller, Amrita Mukherjee, Sandra Muñoz-Braceras, Gina Norato, Katherine Pak, Iago Pinal-Fernandez, Traian Popa, Lauren B Reoma, Michael N Sack, Farinaz Safavi, Leorey N Saligan, Brian A Sellers, Stephen Sinclair, Bryan Smith, Joseph Snow, Stacey Solin, Barbara J Stussman, Giorgio Trinchieri, Sara A Turner, C Stephenie Vetter, Felipe Vial, Carlotta Vizioli, Ashley Williams, Shanna B Yang, Avindra Nath
Post-infectious myalgic encephalomyelitis/chronic fatigue syndrome (PI-ME/CFS) is a disabling disorder, yet the clinical phenotype is poorly defined, the pathophysiology is unknown, and no disease-modifying treatments are available. We used rigorous criteria to recruit PI-ME/CFS participants with matched controls to conduct deep phenotyping. Among the many physical and cognitive complaints, one defining feature of PI-ME/CFS was an alteration of effort preference, rather than physical or central fatigue, due to dysfunction of integrative brain regions potentially associated with central catechol pathway dysregulation, with consequences on autonomic functioning and physical conditioning...
February 21, 2024: Nature Communications
https://read.qxmd.com/read/38356902/aetiological-understanding-of-fibromyalgia-irritable-bowel-syndrome-chronic-fatigue-syndrome-and-classificatory-analogues-a-systematic-umbrella-review
#25
REVIEW
Maria Kleinstäuber, Andreas Schröder, Sarah Daehler, Karen Johanne Pallesen, Charlotte U Rask, Mathias Sanyer, Omer Van den Bergh, Marie Weinreich Petersen, Judith G M Rosmalen
BACKGROUND: This umbrella review systematically assesses the variety and relative dominance of current aetiological views within the scientific literature for the three most investigated symptom-defined functional somatic syndromes (FSS) and their classificatory analogues within psychiatry and psychology. METHOD: An umbrella review of narrative and systematic reviews with and without meta-analyses based on a search of electronic databases (PubMed, Web of Science, Embase, PsychINFO) was conducted...
September 2023: Clin Psychol Eur
https://read.qxmd.com/read/38352048/mixed-methods-system-for-the-assessment-of-post-exertional-malaise-in-myalgic-encephalomyelitis-chronic-fatigue-syndrome-an-exploratory-study
#26
JOURNAL ARTICLE
Barbara Stussman, Brice Calco, Gina Norato, Angelique Gavin, Snigdha Chigurupati, Avindra Nath, Brian Walitt
BACKGROUND: A central feature of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is post-exertional malaise (PEM), which is an acute worsening of symptoms after a physical, emotional and/or mental exertion. Dynamic measures of PEM have historically included scaled questionnaires, which have not been validated in ME/CFS. To enhance our understanding of PEM and how best to measure it, we conducted semistructured qualitative interviews (QIs) at the same intervals as visual analogue scale (VAS) measures after a cardiopulmonary exercise test (CPET)...
2024: BMJ neurology open
https://read.qxmd.com/read/38331137/clinical-and-laboratory-characteristics-of-fatigue-dominant-long-covid-subjects-a-cross-sectional-study
#27
JOURNAL ARTICLE
Jin-Seok Lee, Yujin Choi, Jin-Yong Joung, Chang-Gue Son
BACKGROUND: Long-COVID is defined by persistent symptoms following COVID-19 infection. Approximately 71% of individuals with long-COVID experience ongoing fatigue, post-exertional malaise, and cognitive impairments, which share pathological similarities with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This similarity has prompted studies to explore the characteristics of long-COVID to gain a better understanding of ME/CFS. To gain insights, we investigated the clinical and laboratory characteristics of individuals with fatigue-dominant long-COVID...
February 6, 2024: American Journal of Medicine
https://read.qxmd.com/read/38327880/identification-of-cd8-t-cell-dysfunction-associated-with-symptoms-in-myalgic-encephalomyelitis-chronic-fatigue-syndrome-me-cfs-and-long-covid-and-treatment-with-a-nebulized-antioxidant-anti-pathogen-agent-in-a-retrospective-case-series
#28
JOURNAL ARTICLE
Anna Gil, George E Hoag, John P Salerno, Mady Hornig, Nancy Klimas, Liisa K Selin
BACKGROUND: Patients with post-acute sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection (PASC, i.e., Long COVID) have a symptom complex highly analogous to many features of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), suggesting they may share some aspects of pathogenesis in these similar disorders. ME/CFS is a complex disease affecting numerous organ systems and biological processes and is often preceded by an infection-like episode. It is postulated that the chronic manifestations of illness may result from an altered host response to infection or inability to resolve inflammation, as is being reported in Long COVID...
March 2024: Brain, behavior, & immunity health
https://read.qxmd.com/read/38321938/postacute-sequelae-of-sars-cov-2-in-children
#29
JOURNAL ARTICLE
Suchitra Rao, Rachel S Gross, Sindhu Mohandas, Cheryl R Stein, Abigail Case, Benard Dreyer, Nathan M Pajor, H Timothy Bunnell, David Warburton, Elizabeth Berg, Jonathan B Overdevest, Mark Gorelik, Joshua Milner, Sejal Saxena, Ravi Jhaveri, John C Wood, Kyung E Rhee, Rebecca Letts, Christine Maughan, Nick Guthe, Leah Castro-Baucom, Melissa S Stockwell
The coronavirus disease 2019 (COVID-19) pandemic has caused significant medical, social, and economic impacts globally, both in the short and long term. Although most individuals recover within a few days or weeks from an acute infection, some experience longer lasting effects. Data regarding the postacute sequelae of severe acute respiratory syndrome coronavirus 2 infection (PASC) in children, or long COVID, are only just emerging in the literature. These symptoms and conditions may reflect persistent symptoms from acute infection (eg, cough, headaches, fatigue, and loss of taste and smell), new symptoms like dizziness, or exacerbation of underlying conditions...
February 7, 2024: Pediatrics
https://read.qxmd.com/read/38304426/metabolomic-and-immune-alterations-in-long-covid-patients-with-chronic-fatigue-syndrome
#30
JOURNAL ARTICLE
Suguru Saito, Shima Shahbaz, Xian Luo, Mohammed Osman, Desiree Redmond, Jan Willem Cohen Tervaert, Liang Li, Shokrollah Elahi
INTRODUCTION: A group of SARS-CoV-2 infected individuals present lingering symptoms, defined as long COVID (LC), that may last months or years post the onset of acute disease. A portion of LC patients have symptoms similar to myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS), which results in a substantial reduction in their quality of life. A better understanding of the pathophysiology of LC, in particular, ME/CFS is urgently needed. METHODS: We identified and studied metabolites and soluble biomarkers in plasma from LC individuals mainly exhibiting ME/CFS compared to age-sex-matched recovered individuals (R) without LC, acute COVID-19 patients (A), and to SARS-CoV-2 unexposed healthy individuals (HC)...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38291116/mismatch-between-subjective-and-objective-dysautonomia
#31
JOURNAL ARTICLE
Peter Novak, David M Systrom, Sadie P Marciano, Alexandra Knief, Donna Felsenstein, Matthew P Giannetti, Matthew J Hamilton, Jennifer Nicoloro-SantaBarbara, Tara V Saco, Mariana Castells, Khosro Farhad, David M Pilgrim, William J Mullally
Autonomic symptom questionnaires are frequently used to assess dysautonomia. It is unknown whether subjective dysautonomia obtained from autonomic questionnaires correlates with objective dysautonomia measured by quantitative autonomic testing. The objective of our study was to determine correlations between subjective and objective measures of dysautonomia. This was a retrospective cross-sectional study conducted at Brigham and Women's Faulkner Hospital Autonomic Laboratory between 2017 and 2023 evaluating the patients who completed autonomic testing...
January 30, 2024: Scientific Reports
https://read.qxmd.com/read/38286699/protocol-for-a-scoping-review-of-how-people-with-me-cfs-use-the-internet
#32
JOURNAL ARTICLE
Diane Louise Shortland, Qulsom Fazil, Nutmeg Hallett, Anna Lavis
INTRODUCTION: Myalgic encephalomyelitis (ME) is a chronic neurological illness affecting many bodily systems, commonly the nervous and immune systems. Also known as chronic fatigue syndrome (CFS), key symptoms are extreme fatigue, post-exertional malaise, cognitive problems and sleep disturbance. With reported higher levels of online activity for people with ME/CFS than other patient groups (Westerby 2013 cited in Ytre-Arne) it is crucial to gain more knowledge of usage characteristics and experience of online use, and its integration into everyday life...
January 29, 2024: BMJ Open
https://read.qxmd.com/read/38282368/psychometric-evaluation-of-the-depaul-symptom-questionnaire-short-form-dsq-sf-among-adults-with-long-covid-me-cfs-and-healthy-controls-a-machine-learning-approach
#33
JOURNAL ARTICLE
William J McGarrigle, Jacob Furst, Leonard A Jason
Long COVID shares a number of clinical features with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), including post-exertional malaise, severe fatigue, and neurocognitive deficits. Utilizing validated assessment tools that accurately and efficiently screen for these conditions can facilitate diagnostic and treatment efforts, thereby improving patient outcomes. In this study, we generated a series of random forest machine learning algorithms to evaluate the psychometric properties of the DePaul Symptom Questionnaire-Short Form (DSQ-SF) in classifying large groups of adults with Long COVID, ME/CFS (without Long COVID), and healthy controls...
January 28, 2024: Journal of Health Psychology
https://read.qxmd.com/read/38280185/a-suffering-body-hidden-away-from-others-the-experience-of-being-long-term-bedridden-with-severe-myalgic-encephalomyelitis-chronic-fatigue-syndrome-in-childhood-and-adolescence
#34
JOURNAL ARTICLE
Silje Helen Krabbe, Wenche Schrøder Bjorbaekmo, Anne Marit Mengshoel, Unni Sveen, Karen Synne Groven
In this article, we present findings from a qualitative study examining how young women experience being long-term bedridden with myalgic encephalomyelitis (ME), also known as chronic fatigue syndrome (CFS), during childhood and adolescence. The aim is to explore how young women who fell ill with ME/CFS during childhood and adolescence look back on their lived experience of being long-term bedridden from the vantage point of being fully or partially recovered. Informed by a phenomenological theoretical perspective, the researchers applied a narrative methodological approach involving the analysis of interviews with 13 women, aged 16-29 years at the time of the interview...
January 27, 2024: Nursing Inquiry
https://read.qxmd.com/read/38279014/long-covid-in-pediatrics-epidemiology-diagnosis-and-management
#35
REVIEW
Nicole Toepfner, Folke Brinkmann, Silvia Augustin, Silvia Stojanov, Uta Behrends
This review summarizes current knowledge on post-acute sequelae of COVID-19 (PASC) and post-COVID-19 condition (PCC) in children and adolescents. A literature review was performed to synthesize information from clinical studies, expert opinions, and guidelines. PASC also termed Long COVID - at any age comprise a plethora of unspecific symptoms present later than 4 weeks after confirmed or probable infection with severe respiratory syndrome corona virus type 2 (SARS-CoV-2), without another medical explanation...
January 27, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38278537/myalgic-encephalomyelitis-charities-complain-about-dragons-den-featuring-claims-about-ear-seeds
#36
JOURNAL ARTICLE
Jacqui Wise
No abstract text is available yet for this article.
January 26, 2024: BMJ: British Medical Journal
https://read.qxmd.com/read/38274859/the-role-of-clinical-neurophysiology-in-the-definition-and-assessment-of-fatigue-and-fatigability
#37
REVIEW
Hatice Tankisi, Viviana Versace, Annapoorna Kuppuswamy, Jonathan Cole
Though a common symptom, fatigue is difficult to define and investigate, occurs in a wide variety of neurological and systemic disorders, with differing pathological causes. It is also often accompanied by a psychological component. As a symptom of long-term COVID-19 it has gained more attention. In this review, we begin by differentiating fatigue, a perception, from fatigability, quantifiable through biomarkers. Central and peripheral nervous system and muscle disorders associated with these are summarised...
2024: Clinical Neurophysiology Practice
https://read.qxmd.com/read/38267326/low-dose-naltrexone-improves-post-covid-19-condition-symptoms
#38
JOURNAL ARTICLE
Leonardo Tamariz, Elizabeth Bast, Nancy Klimas, Ana Palacio
PURPOSE: Treatments for myalgic encephalomyelitis and chronic fatigue syndrome can be adapted for post-COVID-19 condition. Our aim was to compare treatments in patients from our post-COVID-19 clinic. METHODS: We conducted a retrospective cohort study and included consecutive patients enrolled in our post-COVID-19 clinic. We included patients who received low-dose naltrexone, amitriptyline, duloxetine, and physical therapy, and evaluated improvements in fatigue, pain, dyspnea, and brain fog recorded in the electronic health record...
January 23, 2024: Clinical Therapeutics
https://read.qxmd.com/read/38256459/advancing-research-and-treatment-an-overview-of-clinical-trials-in-myalgic-encephalomyelitis-chronic-fatigue-syndrome-me-cfs-and-future-perspectives
#39
REVIEW
Katharine A Seton, José A Espejo-Oltra, Karen Giménez-Orenga, Rik Haagmans, Donia J Ramadan, Jesper Mehlsen
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic, debilitating, and multi-faceted illness. Heterogenous onset and clinical presentation with additional comorbidities make it difficult to diagnose, characterize, and successfully treat. Current treatment guidelines focus on symptom management, but with no clear target or causative mechanism, remission rates are low, and fewer than 5% of patients return to their pre-morbid activity levels. Therefore, there is an urgent need to undertake robust clinical trials to identify effective treatments...
January 6, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38256421/igg-antibody-responses-to-epstein-barr-virus-in-myalgic-encephalomyelitis-chronic-fatigue-syndrome-their-effective-potential-for-disease-diagnosis-and-pathological-antigenic-mimicry
#40
JOURNAL ARTICLE
André Fonseca, Mateusz Szysz, Hoang Thien Ly, Clara Cordeiro, Nuno Sepúlveda
Background and Objectives: The diagnosis and pathology of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) remain under debate. However, there is a growing body of evidence for an autoimmune component in ME/CFS caused by the Epstein-Barr virus (EBV) and other viral infections. Materials and Methods: In this work, we analyzed a large public dataset on the IgG antibodies to 3054 EBV peptides to understand whether these immune responses could help diagnose patients and trigger pathological autoimmunity; we used healthy controls (HCs) as a comparator cohort...
January 15, 2024: Medicina
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