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https://www.readbyqxmd.com/read/29352723/which-hiv-infected-adults-with-high-cd4-t-cell-counts-benefit-most-from-immediate-initiation-of-antiretroviral-therapy-a-post-hoc-subgroup-analysis-of-the-start-trial
#1
Jean-Michel Molina, Birgit Grund, Fred Gordin, Ian Williams, Mauro Schechter, Marcello Losso, Matthew Law, Ernest Ekong, Noluthando Mwelase, Athanasios Skoutelis, Martin J Wiselka, Linos Vandekerckhove, Thomas Benfield, David Munroe, Jens D Lundgren, James D Neaton
BACKGROUND: Immediate initiation of antiretroviral therapy (ART) in asymptomatic adults with CD4 counts higher than 500 cells per μL, as recommended, might not always be possible in resource-limited settings. We aimed to identify subgroups of individuals who would benefit most from immediate treatment. METHODS: The START trial was a randomised controlled trial in asymptomatic, HIV-positive adults previously untreated with ART. Participants with CD4 counts higher than 500 cells per μL were randomly assigned to receive immediate ART or to defer ART until CD4 counts were lower than 350 cells per μL...
January 15, 2018: Lancet HIV
https://www.readbyqxmd.com/read/29352716/-echographic-diagnosis-of-missed-early-miscarriage-assessment-of-image-quality
#2
C Barthes, C Mezan De Malartic, C Baumann, H Rousseaux, O Morel
OBJECTIVE: Ultrasound examination plays a central role in case of suspected non-viable pregnancy. A wrong diagnosis might have major consequence in terms of inadequate care, especially in cases of false positive non-viable pregnancy diagnosis. Ultrasound criterions are today well defined. Our objective was to evaluate the feasibility and reproducibility of a novel image-quoting method of first-trimester non-viable pregnancy. METHODS: Thirty images of non-viable pregnancy were twice evaluated with blinded proofreading...
January 15, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29352696/safety-and-efficacy-of-prostatic-artery-chemoembolization-for-prostate-cancer-initial-experience
#3
João Pisco, Tiago Bilhim, Nuno V Costa, Manuel Pinto Ribeiro, Lucia Fernandes, António G Oliveira
PURPOSE: To evaluate outcome of prostatic artery chemoembolization for patients with prostate cancer (PCa). MATERIALS AND METHODS: This single-center prospective cohort study was conducted between August 2013 and July 2016 in 20 patients with PCa who underwent chemoembolization. Mean patient age was 67.5 years ± 6.4. Gleason score was 6-10, and staging was T2N0M0. Fifteen patients refused prostatectomy and 5 wanted to stop hormonal therapy because of side effects...
January 15, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29352677/surface-structure-and-tribology-of-legless-squamate-reptiles
#4
REVIEW
Hisham A Abdel-Aal
Squamate reptiles (around 10,000 species of snakes and lizards) comprise a myriad of distinct terrestrial vertebrates. The diversity within this biological group offers a great opportunity for customized bio-inspired solutions that address a variety of current technological problems especially within the realm of surface engineering and tribology. One subgroup within squamata is of interest in that context, namely the legless reptiles (mainly snakes and few lizards). The promise of that group lies within their functional adaptation as manifested in optimized surface designs and locomotion that is distinguished by economy of effort even when functioning within hostile tribological environments...
November 8, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29352663/early-versus-delayed-closure-of-bladder-exstrophy-a-national-surgical-quality-improvement-program-pediatric-analysis
#5
J J Ahn, M Shnorhavorian, C Katz, A B Goldin, P A Merguerian
INTRODUCTION: Delayed closure of bladder exstrophy has become more popular; however, there is limited the evidence of its success. Existing literature focuses on intermediate and long-term outcomes, and short-term postoperative outcomes are limited by the small number of cases and varying follow-up methods. OBJECTIVE: The objectives of the current study were to: 1) compare 30-day complications after early and delayed closure of bladder exstrophy, and 2) evaluate practice patterns of bladder exstrophy closure...
December 15, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29352627/indications-and-limits-of-stereoelectroencephalography-seeg
#6
REVIEW
Lorella Minotti, Alexandra Montavont, Julia Scholly, Louise Tyvaert, Delphine Taussig
Epilepsy surgery is now an accepted treatment to achieve seizure control in carefully selected patients, both children and adults, suffering from drug-resistant focal epilepsy. Although surgical strategies can often be defined on the basis of non-invasive diagnostic procedures, and despite the recent advances in this field, an increasing number of more complex cases requires invasive EEG (iEEG) to provide precise information on the localization of the epileptogenic zone (EZ), its relationships with eloquent cortex (EC), and the feasibility of a tailored surgical resection...
January 15, 2018: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/29352619/quantitative-evaluation-of-enzyme-induced-porcine-articular-cartilage-degeneration-based-on-observation-of-entire-cartilage-layer-using-ultrasound
#7
Jingchen Zhang, Liying Xiao, Lingying Tong, Chao Wan, Zhixiu Hao
Enzyme-induced articular cartilage degeneration resembling osteoarthritis was evaluated using a newly defined acoustic parameter, the "averaged magnitude ratio" (AMR), which has been suggested as an indicator of articular cartilage degeneration. In vitro experiments were conducted on porcine cartilage samples digested with trypsin for 2 h (n = 10) and 4 h (n = 13) and healthy control samples (n = 13). AMR was determined with 15- and 25-MHz ultrasound, and the integrated reflection coefficient (IRC) and apparent integrated backscattering coefficient (AIB) were also calculated for comparison...
January 15, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29352614/who-is-in-and-who-is-out-of-the-mouth-salivary-glands-and-jaws-sections-of-the-4th-edition-of-the-who-classification-of-head-and-neck-tumours
#8
REVIEW
R A Kennedy
This review of changes to the 4th edition of the WHO classification of head and neck tumours focuses on their impact on the surgical care of diseases that affect the salivary glands, jaws, and oral cavity. Updates to the chapter on the salivary glands include the addition of secretory carcinoma and sclerosing polycystic adenosis. The odontogenic cysts are back, and the odontogenic keratocyst is listed among them, as it has now lost its brief and confusing designation as a neoplasm. The newly-defined sclerosing odontogenic carcinoma and primordial odontogenic tumour have been added...
January 15, 2018: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29352598/who-consultation-on-etec-and-shigella-burden-of-disease-geneva-6-7th-april-2017-meeting-report
#9
Divya Hosangadi, Peter G Smith, David C Kaslow, Birgitte K Giersing
According to the 2015 Global Burden of Disease Study, diarrhea ranked ninth among causes of death for all ages, and fourth among children under 5 years old, accounting for an estimated 499,000 deaths in this young age group. It was also the second most common cause of years lived with disability (2.39 billion YLDs). The goal of the WHO/UNICEF Integrated Global Action Plan for the Prevention and Control of Pneumonia and Diarrhea (GAPPD) is to reduce deaths from diarrhea in children under 5 years of age to less than 1 per 1000 live births, by 2025...
January 15, 2018: Vaccine
https://www.readbyqxmd.com/read/29352592/development-and-validation-of-an-icd-10-based-disability-predictive-index-for-patients-admitted-to-hospitals-with-trauma
#10
Tomoki Wada, Hideo Yasunaga, Hayato Yamana, Hiroki Matsui, Kiyohide Fushimi, Naoto Morimura
BACKGROUND: There was no established disability predictive measurement for patients with trauma that could be used in administrative claims databases. The aim of the present study was to develop and validate a diagnosis-based disability predictive index for severe physical disability at discharge using the International Classification of Diseases, 10th revision (ICD-10) coding. METHODS: This retrospective observational study used the Diagnosis Procedure Combination database in Japan...
December 28, 2017: Injury
https://www.readbyqxmd.com/read/29352525/an-mrm-based-cytokeratin-marker-assay-as-a-tool-for-cancer-studies-application-to-lung-cancer-pleural-effusions
#11
Anna Perzanowska, Agnieszka Fatalska, Grzegorz Wojtas, Andrzej Lewandowicz, Agata Michalak, Grzegorz Krasowski, Christoph H Borchers, Michal Dadlez, Dominik Domanski
PURPOSE: The goal of this work was to develop an LC-MRM assay for the quantitative analysis of a set of established and diagnostically important cytokeratin (CK) markers used in cancer diagnosis, prognosis and therapy monitoring. Secondly, the potential of this assay in lung cancer diagnosis through pleural effusion (PE) analysis was examined. EXPERIMENTAL DESIGN: A multiplexed MRM assay was developed for 17 CKs and their select caspase-cleaved fragments. Isotope-labeled standard peptides were used for high assay specificity and absolute peptide quantitation; with robust standard-flow LC coupled to a latest-generation triple-quadrupole instrument for high sensitivity...
January 19, 2018: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29352521/microdenervation-of-the-spermatic-cord-for-post-vasectomy-pain-syndrome
#12
Wei Phin Tan, Peter N Tsambarlis, Laurence A Levine
INTRODUCTION: Post Vasectomy Pain Syndrome (PVPS) is an uncommon urologic problem that remains a challenge to manage. We aim to evaluate the outcomes of patients who underwent microdenervation of the spermatic cord (MDSC) for PVPS at our institution. METHODS: A retrospective study of all patients who underwent MDSC for PVPS by a single surgeon from March 2002 to October 2016 was performed. Pain was documented using the numerical rating scale (NRS). Spermatic cord block (SCB) was performed on all patients and success was defined as NRS ≤1 for >4 hours...
January 20, 2018: BJU International
https://www.readbyqxmd.com/read/29352514/an-integrative-review-exploring-the-physical-and-psychological-harm-inherent-in-using-restraint-in-mental-health-inpatient-settings
#13
Pauline Cusack, Frank Patrick Cusack, Sue McAndrew, Mick McKeown, Joy Duxbury
In Western society, policy and legislation seeks to minimize restrictive interventions, including physical restraint; yet research suggests the use of such practices continues to raise concerns. Whilst international agreement has sought to define physical restraint, diversity in the way in which countries use restraint remains disparate. Research to date has reported on statistics regarding restraint, how and why it is used, and staff and service user perspectives about its use. However, there is limited evidence directly exploring the physical and psychological harm restraint may cause to people being cared for within mental health inpatient settings...
January 19, 2018: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/29352464/origin-of-heterogeneous-spiking-patterns-from-continuously-distributed-ion-channel-densities-a-computational-study-in-spinal-dorsal-horn-neurons
#14
Arjun Balachandar, Steven A Prescott
Neurons are often classified by spiking pattern. Yet some neurons exhibit distinct patterns under subtly different test conditions, which suggests that they operate near an abrupt transition, or bifurcation. A set of such neurons may exhibit heterogeneous spiking patterns not because of qualitative differences in which ion channels they express, but rather because quantitative differences in expression levels cause neurons to operate on opposite sides of a bifurcation. Neurons in the spinal dorsal horn, for example, respond to somatic current injection with patterns that include tonic-, single-, gap-, delayed- and reluctant-spiking...
January 20, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29352453/measuring-surgical-safety-during-minimally-invasive-surgical-procedures-a-validation-study
#15
Mathijs D Blikkendaal, Sara R C Driessen, Sharon P Rodrigues, Johann P T Rhemrev, Maddy J G H Smeets, Jenny Dankelman, John J van den Dobbelsteen, Frank Willem Jansen
BACKGROUND: During the implementation of new interventions (i.e., surgical devices and technologies) in the operating room, surgical safety might be compromised. Current safety measures are insufficient in detecting safety hazards during this process. The aim of the study was to observe whether surgical teams are capable of measuring surgical safety, especially with regard to the introduction of new interventions. METHODS: A Surgical Safety Questionnaire was developed that had to be filled out directly postoperative by three surgical team members...
January 19, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29352452/the-determinants-of-reduced-dietary-intake-in-hospitalised-colorectal-cancer-patients
#16
Anne van der Werf, Katherine Arthey, Michael Hiesmayr, Isabella Sulz, Karin Schindler, Alessandro Laviano, Jacqueline Langius, Marian de van der Schueren
PURPOSE: Patients with colorectal cancer (CRC) often experience malnutrition and weight loss, largely resulting from reduced dietary intake. The aim of this study was to identify determinants of reduced dietary intake in order to facilitate early recognition of malnutrition and optimise nutritional treatment. METHODS: Data from nutritionDay, an international 1-day survey investigating patient, disease and food profiles, were used. To identify determinants of dietary intake, defined as normal vs...
January 19, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29352437/cost-effectiveness-of-treatments-for-chronic-constipation-a-systematic-review
#17
REVIEW
Dolly Han, Nicolas Iragorri, Fiona Clement, Diane Lorenzetti, Eldon Spackman
BACKGROUND: Chronic constipation (CC) has a significant impact on patients' quality of life and imposes an economic burden on individuals and the healthcare system. Treatment options include dietary changes, lifestyle modifications, fibre supplements, stool softeners, and laxatives. OBJECTIVE: We undertook this systematic review to comprehensively evaluate the cost effectiveness of treatments for CC. METHODS: We searched ten common databases to identify economic evaluations published to 13 June 2017...
January 19, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29352435/outcome-of-hip-and-knee-periprosthetic-joint-infections-caused-by-pathogens-resistant-to-biofilm-active-antibiotics-results-from-a-prospective-cohort-study
#18
Doruk Akgün, Carsten Perka, Andrej Trampuz, Nora Renz
BACKGROUND: Periprosthetic joint infections (PJI) caused by pathogens, for which no biofilm-active antibiotics are available, are often referred to as difficult-to-treat (DTT). However, it is unclear whether the outcome of DTT PJI is worse than those of non-DTT PJI. We evaluated the outcome of DTT and non-DTT PJI in a prospective cohort treated with a two-stage exchange according to a standardized algorithm. METHODS: Patients with hip and knee PJI from 2013 to 2015 were prospectively included and followed up for ≥ 2 years...
January 19, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29352425/safety-and-efficacy-of-nanocurcumin-as-add-on-therapy-to-riluzole-in-patients-with-amyotrophic-lateral-sclerosis-a-pilot-randomized-clinical-trial
#19
Mona Ahmadi, Elmira Agah, Shahriar Nafissi, Mahmoud Reza Jaafari, Mohammad Hossein Harirchian, Payam Sarraf, Sara Faghihi-Kashani, Seyed Jalal Hosseini, Abdolreza Ghoreishi, Vajiheh Aghamollaii, Mostafa Hosseini, Abbas Tafakhori
The objective of present study was to assess the safety and efficacy of nanocurcumin as an anti-inflammatory and antioxidant agent in adults with amyotrophic lateral sclerosis (ALS). We conducted a 12-month, double-blind, randomized, placebo-controlled trial at a neurological referral center in Iran. Eligible patients with a definite or probable ALS diagnosis were randomly assigned to receive either nanocurcumin (80 mg daily) or placebo in a 1:1 ratio. A computerized random number generator was used to prepare the randomization list...
January 19, 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29352349/factors-affecting-n-terminal-pro-b-type-natriuretic-peptide-levels-in-preterm-infants-and-use-in-determination-of-haemodynamic-significance-of-patent-ductus-arteriosus
#20
Sarah Louise Harris, Kiran More, Bronwyn Dixon, Richard Troughton, Chris Pemberton, John Horwood, Nicola Ellis, Nicola Austin
This study aimed to investigate factors affecting N-terminal pro-B-type natriuretic peptide (NTproBNP) in preterm infants and the ability of NTproBNP to predict haemodynamically significant patent ductus arteriosus (HsPDA). Prospective cohort study of 51 infants < 30 weeks gestation. Blood NTproBNP and heart ultrasound were performed on day of life 3, 10, 28 and 36 weeks corrected age. NTproBNP levels analysed for prediction of HsPDA. The effect of gestational age, ventilation, hypoxia, bronchopulmonary dysplasia (BPD), creatinine and haemoglobin levels on NTproBNP levels were investigated...
January 19, 2018: European Journal of Pediatrics
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