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https://www.readbyqxmd.com/read/28918614/modifiable-co-morbidities-trends-during-hospital-admissions-for-obesity-in-france-2009-2014
#1
Pierre Nanyan
Obesity is a growing public health problem in France, but modifiable co-morbidities in obese patients during their hospital admissions excluding bariatric surgery are lacking. Data were extracted from the French national hospital discharge database. Data on patient admissions, age, gender, and length of stay were extracted by selecting any stay coded primary as obesity. Obesity was defined as body mass index (BMI) between 30-39 kg/m², and morbid obesity as BMI≥40 kg/m². Only modifiable co-morbidities frequently diagnosed during the 6-year period with a rate≥3% were chosen...
July 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28918607/modeling-the-ph-and-temperature-dependence-of-aqueousphase-hydroxyl-radical-reaction-rate-constants-of-organic-micropollutants-using-qspr-approach
#2
Shikha Gupta, Nikita Basant
Designing of advanced oxidation process (AOP) requires knowledge of the aqueous phase hydroxyl radical ((●)OH) reactions rate constants (k OH), which are strictly dependent upon the pH and temperature of the medium. In this study, pH- and temperature-dependent quantitative structure-property relationship (QSPR) models based on the decision tree boost (DTB) approach were developed for the prediction of k OH of diverse organic contaminants following the OECD guidelines. Experimental datasets (n = 958) pertaining to the k OH values of aqueous phase reactions at different pH (n = 470; 1...
September 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28918520/derivation-of-human-induced-pluripotent-stem-cell-ipsc-lines-and-mechanism-of-pluripotency-historical-perspective-and-recent-advances
#3
REVIEW
Arvind Chhabra
Derivation of human embryonic stem cell (hES) lines in 1998 was not only a major technological breakthrough in the field of regenerative medicine; it also triggered a passionate debate about the ethical issues associated with the utilization of human embryos for derivation of hESC lines. Successful derivation of induced pluripotent stem cell (iPS) lines from human somatic cells with defined reprogramming factors by Shinya Yamanaka`s group in 2007 was another breakthrough that generated enormous excitement and hope for the development of donor-specific personalized cell replacement therapies (CRT) without the ethical dilemma associated with it...
September 16, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28918506/young-athletes-after-acl-reconstruction-with-quadriceps-strength-asymmetry-at-the-time-of-return-to-sport-demonstrate-decreased-knee-function-1%C3%A2-year-later
#4
Matthew P Ithurburn, Alex R Altenburger, Staci Thomas, Timothy E Hewett, Mark V Paterno, Laura C Schmitt
PURPOSE: Quadriceps femoris (QF) strength deficits at return-to-sport (RTS) after ACL reconstruction (ACLR) contribute to decreased knee function at the same time point. However, the impact of QF strength at RTS on longitudinal function has not been examined. The purpose of this study was to test the hypothesis that young athletes after ACLR with QF strength asymmetry at RTS would demonstrate decreased knee-related function and lower proportions of functional recovery at 1 year post-RTS compared to young athletes following ACLR with nearly symmetric QF strength at RTS...
September 16, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28918489/yersinia-enterocolitica-biotype-1a-a-possible-new-trigger-of-reactive-arthritis
#5
Riitta Tuompo, Timo Hannu, Elisa Huovinen, Leila Sihvonen, Anja Siitonen, Marjatta Leirisalo-Repo
Yersinia enterocolitica (YE) biotype 1A is generally considered non-pathogenic, and the role of it in causing reactive musculoskeletal complications is unclear. We evaluated the capability of YE biotype 1A to induce reactive arthritis (ReA) and other reactive musculoskeletal symptoms. Analysis of self-reported musculoskeletal symptoms was supplemented with a telephone interview (with a permission to acquire copies of patient files from a local physician or hospital) and/or clinical examination of subjects with recent musculoskeletal symptoms after a positive stool culture for YE...
September 16, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28918487/clinical-risk-stratification-of-paediatric-renal-transplant-recipients-using-c1q-and-c3d-fixing-of-de-novo-donor-specific-antibodies
#6
Jon Jin Kim, Olivia Shaw, Chloe Martin, George Michaelides, Ramnath Balasubramaniam, Neil J Sebire, Nizam Mamode, Anthony Dorling, Robert Vaughan, Stephen D Marks
INTRODUCTION: We have previously shown that children who developed de novo donor-specific human leukocyte antigen (HLA) antibodies (DSA) had greater decline in allograft function. We hypothesised that patients with complement-activating DSA would have poorer renal allograft outcomes. METHODS: A total of 75 children developed DSA in the original study. The first positive DSA sample was subsequently tested for C1q and C3d fixing. The primary event was defined as 50% reduction from baseline estimated glomerular filtration rate and was analysed using the Kaplan-Meier estimator...
September 16, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28918462/development-of-a-new-scoring-system-to-predict-5-year-incident-diabetes-risk-in-middle-aged-and-older-chinese
#7
Xu Han, Jing Wang, Yaru Li, Hua Hu, Xiulou Li, Jing Yuan, Ping Yao, Xiaoping Miao, Sheng Wei, Youjie Wang, Yuan Liang, Xiaomin Zhang, Huan Guo, An Pan, Handong Yang, Tangchun Wu, Meian He
AIMS: The aim of this study was to develop a new risk score system to predict 5-year incident diabetes risk among middle-aged and older Chinese population. METHODS: This prospective study included 17,690 individuals derived from the Dongfeng-Tongji cohort. Participants were recruited in 2008 and were followed until October 2013. Incident diabetes was defined as self-reported clinician diagnosed diabetes, fasting glucose ≥7.0 mmol/l, or the use of insulin or oral hypoglycemic agent...
September 16, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28918459/hla-class-i-expression-predicts-prognosis-and-therapeutic-benefits-from-tyrosine-kinase-inhibitors-in-metastatic-renal-cell-carcinoma-patients
#8
Jiajun Wang, Li Liu, Yang Qu, Wei Xi, Yu Xia, Qi Bai, Ying Xiong, Qilai Long, Jiejie Xu, Jianming Guo
PURPOSE: Classical HLA class I antigen is highly involved in antigen presentation and adaptive immune response against tumor. In this study, we explored its predictive value for treatment response and survival in metastatic renal-cell carcinoma (mRCC) patients. EXPERIMENTAL DESIGN: A TKI cohort of 111 mRCC patients treated with sunitinib or sorafenib and a non-TKI cohort of 160 mRCC patients treated with interleukin-2 or interferon-α-based immunotherapy at a single institution were retrospectively enrolled...
September 16, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28918447/an-improved-crystal-structure-of-c-phycoerythrin-from-the-marine-cyanobacterium-phormidium-sp-a09dm
#9
Ravi R Sonani, Aleksander W Roszak, Claire Ortmann de Percin Northumberland, Datta Madamwar, Richard J Cogdell
C-Phycoerythrin (PE) from Phormidium sp. A09DM has been crystallized using different conditions and its structure determined to atomic resolution (1.14 Å). In order for the pigment present, phycoerythrobilin (PEB), to function as an efficient light-harvesting molecule it must be held rigidly (Kupka and Scheer in Biochim Biophys Acta 1777:94-103, 2008) and, moreover, the different PEB molecules in PE must be arranged, relative to each other, so as to promote efficient energy transfer between them. This improved structure has allowed us to define in great detail the structure of the PEBs and their binding sites...
September 16, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/28918440/interpersonal-sensitivity-and-persistent-attenuated-psychotic-symptoms-in-adolescence
#10
Alice Masillo, M Brandizzi, L R Valmaggia, R Saba, N Lo Cascio, J F Lindau, L Telesforo, P Venturini, D Montanaro, D Di Pietro, M D'Alema, P Girardi, P Fiori Nastro
Interpersonal sensitivity defines feelings of inner-fragility in the presence of others due to the expectation of criticism or rejection. Interpersonal sensitivity was found to be related to attenuated positive psychotic symptom during the prodromal phase of psychosis. The aims of this study were to examine if high level of interpersonal sensitivity at baseline are associated with the persistence of attenuated positive psychotic symptoms and general psychopathology at 18-month follow-up. A sample of 85 help-seeking individuals (mean age = 16...
September 16, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28918427/safety-of-monitored-anesthesia-care-using-propofol-based-sedation-for-pleuroscopy
#11
Erik Vakil, Mona Sarkiss, David Ost, Macarena R Vial, Roberto F Casal, Georgie A Eapen, Horiana B Grosu
BACKGROUND: The optimal approach to sedation for pleuroscopy remains undefined. Propofol is the favored sedative-hypnotic for many proceduralists but has a narrow therapeutic window and the risk for oversedation is high. Propofol-based sedation administered by anesthesiologists and the routine use of end-tidal capnography and bispectral index (BIS) monitoring may attenuate risks of complications. OBJECTIVES: The purpose of our study was to evaluate the safety and efficacy of monitored anesthesia care for pleuroscopy...
September 16, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28918411/combining-cd4-recovery-and-cd4-cd8-ratio-restoration-as-an-indicator-for-evaluating-the-outcome-of-continued-antiretroviral-therapy-an-observational-cohort-study
#12
Shui Shan Lee, Ngai Sze Wong, Bonnie Chun Kwan Wong, Ka Hing Wong, Kenny Chi Wai Chan
OBJECTIVES: Immune recovery following highly active antiretroviral therapy (HAART) is commonly assessed by the degree of CD4 reconstitution alone. In this study, we aimed to assess immune recovery by incorporating both CD4 count and CD4:CD8 ratio. DESIGN: Observational cohort study SETTING AND PARTICIPANTS: Clinical data from Chinese HIV-positive patients attending the largest HIV service in Hong Kong and who had been on HAART for ≥4 years were accessed. MAIN OUTCOME MEASURES: Optimal immune outcome was defined as a combination of a CD4 count ≥500/μL and a CD4:CD8 ratio ≥0...
September 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28918408/effectiveness-cost-utility-and-implementation-of-a-decision-aid-for-patients-with-localised-prostate-cancer-and-their-partners-study-protocol-of-a-stepped-wedge-cluster-randomised-controlled-trial
#13
Hoda H M Al-Itejawi, Cornelia F van Uden-Kraan, Peter M van de Ven, Veerle M H Coupé, André N Vis, Jakko A Nieuwenhuijzen, Jeroen A van Moorselaar, Irma M Verdonck-de Leeuw
INTRODUCTION: Patient decision aids (PDAs) have been developed to help patients make an informed choice for a treatment option. Despite proven benefits, structural implementation falls short of expectations. The present study aims to assess the effectiveness and cost-utility of the PDA among newly diagnosed patients with localised prostate cancer and their partners, alongside implementation of the PDA in routine care. METHODS/ANALYSIS: A stepped-wedge cluster randomised trial will be conducted...
September 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28918404/combined-caesarean-with-splenectomy-in-pregnancy-with-portal-hypertension-defining-plausibility
#14
Manjunath Maruti Pol, Latika Uniyal Chawla, Yashwant Singh Rathore, Ritesh Goel
24-year-old woman at 28 weeks gestation was referred from peripheral hospital with diagnosis of pregnancy with portal hypertension. She had received multiple transfusion for pancytopaenia in the past and had undergone endoscopic sclerotherapy for oesophageal varices. Initially, she was admitted in our hospital at 28 weeks gestation for blood transfusion and was evaluated by multispecialty team of doctors. She was advised splenectomy for transfusion-dependent pancytopaenia secondary to hypersplenism in non-cirrhotic portal hypertension...
September 15, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28918400/healthcare-resource-use-and-costs-of-severe-uncontrolled-eosinophilic-asthma-in-the-uk-general-population
#15
Marjan Kerkhof, Trung N Tran, Joan B Soriano, Sarowar Golam, Danny Gibson, Elizabeth V Hillyer, David B Price
BACKGROUND: Little is known about the prevalence of severe, uncontrolled eosinophilic asthma (SUEA) and associated costs. AIMS: We sought to determine the prevalence of SUEA and compare asthma-related healthcare resource use (HCRU) and associated costs with overall means for a general asthma population. METHODS: This cohort study evaluated anonymised medical record data (December 1989 through June 2015) from the Clinical Practice Research Datalink and the Optimum Patient Care Research Database to study UK patients with active asthma (diagnostic code and one or more drug prescriptions in the baseline year), aged 5 years and older, without concomitant COPD, and with recorded eosinophil count...
September 16, 2017: Thorax
https://www.readbyqxmd.com/read/28918390/a-glossary-for-big-data-in-population-and-public-health-discussion-and-commentary-on-terminology-and-research-methods
#16
Daniel Fuller, Richard Buote, Kevin Stanley
The volume and velocity of data are growing rapidly and big data analytics are being applied to these data in many fields. Population and public health researchers may be unfamiliar with the terminology and statistical methods used in big data. This creates a barrier to the application of big data analytics. The purpose of this glossary is to define terms used in big data and big data analytics and to contextualise these terms. We define the five Vs of big data and provide definitions and distinctions for data mining, machine learning and deep learning, among other terms...
September 16, 2017: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/28918381/assessing-decisional-capacity-for-research-participation-in-psychiatric-patients-and-their-relatives
#17
Donae Elizabeth George, Saumil Dholakia, Prathap Tharyan
A cross-sectional study among adult inpatients with non-organic psychiatric disorders, and among their key relatives, assessed their comprehension and recall of key information in consent forms. It also assessed their capacity to consent to participate in two hypothetical randomised controlled trials (RCTs) with different potential risks and burdens, using structured questionnaires and recorded interviews. Of the 24 participants (12 patient-key relative dyads), seven patients (58%) and three key relatives (25%) were clinically judged to lack the capacity to consent...
August 8, 2017: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/28918357/long-term-follow-up-after-tibialis-anterior-tendon-shortening-in-combination-with-achilles-tendon-lengthening-in-spastic-equinus-in-cerebral-palsy
#18
Michèle Kläusler, Bernhard Maria Speth, Reinald Brunner, Oren Tirosh, Carlo Camathias, Erich Rutz
Using Tibialis Anterior Shortening (TATS) in combination with Achilles Tendon Lengthening (TAL) to treat spastic equinus in children with cerebral palsy (CP) was described in 2011. Short-term results have indicated a good outcome, especially an improvement of the drop foot in swing phase and the correction of equinus in stance phase. The aim of this study was to analyse the results of the long-term follow-up and to determine the relapse rate of TATS and TAL. The kinematics of the sagittal, frontal and transversal planes were measured by using instrumented 3D gait analysis at three defined time points and then described using the Gait Profile Score (GPS) and Movement Analysis Profile (MAP)...
August 30, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28918351/susceptibility-profiles-of-bacteria-causing-urinary-tract-infection-in-southern-tunisia
#19
Sonda Guermazi-Toumi, Sirine Boujlel, Mouna Assoudi, Riadh Issaoui, Sonia Tlili, Mohamed Ennaceur Hlaiem
OBJECTIVES: The aim of this study was to determine the epidemiological profile and the antibiotic resistance of bacteria responsible for urinary infections diagnosed in the department of microbiology of the regional hospital Houcine Bouzaiene (Gafsa) in the south west of Tunisia. METHODS: All the cytobacteriological urine samples analyzed from 1 January 2015 to 30 June 2016 were included in the study. The adopted criteria to define urinary infection were: leukocyturia >10(4)/ml and bacteriuria >10(5)CFU/ml...
September 13, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28918347/anaerobic-digestion-of-brewery-spent-grains-trace-elements-addition-requirement
#20
Claire Bougrier, Delphine Dognin, Cécile Laroche, Valérie Gonzalez, Dalel Benali-Raclot, Jesús Andrés Cacho Rivero
The current study evaluates and compares the stability of anaerobic digestion of Brewery Spent Grains (BSG) with and without addition of nutrients. Based on the composition of the BSG two levels of nutrients addition were defined. Control reactor, without addition of nutrients, showed signs of instability after 3months of operation and collapsed. On the contrary, supplemented reactors led to a COD removal rate of 60% and a methane production of 280NLCH4.kg(-1) VSadded. According to these results, it was possible to define an additive solution adapted to BSG degradation...
September 2, 2017: Bioresource Technology
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