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https://www.readbyqxmd.com/read/29778086/pelvic-floor-physical-therapy-and-women-s-health-promotion
#1
REVIEW
Samantha Lawson, Ashley Sacks
Pelvic floor dysfunction is defined as abnormal function of the pelvic floor and includes conditions that can have significant adverse impacts on a woman's quality of life, including urinary incontinence (stress, urge, and mixed), fecal incontinence, pelvic organ prolapse, sexual dysfunction, diastasis recti abdominis, pelvic girdle pain, and chronic pain syndromes. Women's health care providers can screen for, identify, and treat pelvic floor dysfunction. This article examines the case of a woman with multiple pelvic-floor-related problems and presents the evidence for the use of pelvic floor physical therapy (PFPT) for pregnancy-related pelvic floor dysfunction...
May 19, 2018: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/29778047/source-identification-and-spatial-distribution-of-arsenic-and-heavy-metals-in-agricultural-soil-around-hunan-industrial-estate-by-positive-matrix-factorization-model-principle-components-analysis-and-geo-statistical-analysis
#2
Xiaowen Zhang, Shuai Wei, Qianqian Sun, Syed Abdul Wadood, Boli Guo
Characterizing the distribution and defining potential sources of arsenic and heavy metals are the basic preconditions for reducing the contamination of heavy metals and metalloids. 71 topsoil samples and 61 subsoil samples were collected by grid method to measure the concentration of cadmium (Cd), arsenic (As), lead (Pb), copper (Cu), zinc (Zn), nickel (Ni) and chromium (Cr). Principle components analysis (PCA), GIS-based geo-statistical methods and Positive Matrix Factorization (PMF) were applied. The results showed that the mean concentrations were 9...
May 16, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29778034/early-discharge-of-patients-with-pulmonary-embolism-in-daily-clinical-practice-a-prospective-observational-study-comparing-clinical-gestalt-and-clinical-rules
#3
Simone Vanni, Cecilia Becattini, Peiman Nazerian, Carlo Bova, Valerio Teodoro Stefanone, Ludovica Anna Cimini, Gabriele Viviani, Cosimo Caviglioli, Michela Sanna, Giuseppe Pepe, Stefano Grifoni
OBJECTIVES: To estimate the efficiency and safety of clinicians' gestalt in the identification of patients with pulmonary embolism (PE) candidates for early discharge and to compare the efficiency and safety of clinical gestalt with that of the Pulmonary Embolism Severity Index (PESI), the simplified PESI (sPESI) and the Hestia criteria (HC). METHODS: Consecutive adult patients presenting to the emergency department of four Italian hospitals with confirmed diagnosis of PE were included...
May 8, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29778030/retrospective-genotype-phenotype-analysis-in-a-305-patient-cohort-referred-for-testing-of-a-targeted-epilepsy-panel
#4
Andrew N Hesse, Jennifer Bevilacqua, Kritika Shankar, Honey V Reddi
PURPOSE: Epilepsy is a diverse neurological condition with extreme genetic and phenotypic heterogeneity. The introduction of next-generation sequencing into the clinical laboratory has made it possible to investigate hundreds of associated genes simultaneously for a patient, even in the absence of a clearly defined syndrome. This has resulted in the detection of rare and novel mutations at a rate well beyond our ability to characterize their effects. This retrospective study reviews genotype data in the context of available phenotypic information on 305 patients spanning the epileptic spectrum to identify established and novel patterns of correlation...
May 16, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29777895/asymmetry-of-cerebral-peduncles-for-predicting-motor-function-restoration-in-young-patients-before-hemispherectomy
#5
Xiu-Yu Du, Si-Chang Chen, Yu-Guang Guan, Jing-Jing Gu, Meng Zhao, Tian-Fu Li, Jun-Hong Pan, Guo-Ming Luan
OBJECTIVE: Hemispherectomy has been successfully used for medically intractable epilepsy patients. However, it is difficult to predict postoperative motor function. The aim of the present study was to analyze whether the preoperative asymmetry of cerebral peduncles could be used to predict motor function restoration before hemispherectomy for young patients with medically intractable epilepsy. METHODS: The clinical record and MRI data of 53 patients were retrospectively analyzed...
May 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29777887/linear-cutting-trepanation-in-italy-a-unique-case-from-hellenistic-sicily-3-rd-century-bc
#6
REVIEW
Giorgia Tulumello, Giulia Riccomi, Simona Minozzi, Sveva Longo, Marcello Longo, Valentina Giuffra
During the archaeological excavations conducted in the Hellenistic necropolis discovered in Messina (Sicily, Italy) dating back to the 3rd century BC., a skeleton showing evidence of cranial traumas and surgical intervention was found. The skull, belonging to a young adult male, presented signs of four head injuries produced by both blunt and sharp-edged instruments. The first two lesions, located on the frontal bone, were produced by blunt blows and showed signs of long-time survival. The third lesion, located on the inferior portion of the right parietal, suggests a perimortem non-penetrating linear cut probably caused by a blade instrument...
May 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29777886/stereotactic-radiosurgery-for-high-grade-intracranial-dural-arteriovenous-fistulas
#7
Ching-Jen Chen, Thomas J Buell, Joshua Diamond, Dale Ding, Jeyan S Kumar, Davis G Taylor, Cheng-Chia Lee, Jason P Sheehan
OBJECTIVE: Factors associated with favorable outcome following stereotactic radiosurgery (SRS) for dural arteriovenous fistulas (DAVFs) with cortical venous reflux (CVR) are incompletely understood. The aim of this retrospective cohort study is to assess the outcomes after SRS for high-grade DAVFs and identify predictors. METHODS: We performed a retrospective review of consecutive patients with high-grade DAVFs, defined as the presence of CVR, who underwent SRS between 1989 and 2017...
May 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29777882/factors-predicting-hypocalcemia-after-total-thyroidectomy-a-retrospective-cohort-analysis
#8
Claudius Falch, Jan Hornig, Moritz Senne, Manuel Braun, Alfred Konigsrainer, Andreas Kirschniak, Sven Muller
BACKGROUND: Hypocalcemia after total thyroidectomy is the most frequent complication resulting in prolongation of hospitalisation. Therefore we aimed to analyse clinical risk factors predictive for hypocalcemia and its long term persistence after total thyroidectomy. METHODS: Retrospective analysis of patients undergoing total thyroidectomy from 2005 until 2013. Outcome measures were initial postoperative hypocalcemia defined as serum calcium below 2.0 mmol/l after total thyroidectomy within 48 h and persistent hypocalcemia defined as serum calcium below 2...
May 16, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29777867/antibiotic-exposure-prior-to-respiratory-viral-infection-is-associated-with-progression-to-lower-respiratory-tract-disease-in-allogeneic-hematopoietic-cell-transplant-recipients
#9
Chikara Ogimi, Elizabeth M Krantz, Jonathan L Golob, Alpana Waghmare, Catherine Liu, Wendy M Leisenring, Christopher R Woodard, Sara Marquis, Jane M Kuypers, Keith R Jerome, Steven A Pergam, David N Fredricks, Mohamed L Sorror, Janet A Englund, Michael Boeckh
INTRODUCTION: Recent publications note an association between antibiotic exposure and respiratory viral infections (RVIs). Antibiotics affect microbiota and impair immune response against RVIs in mice, and low microbiome diversity is associated with pulmonary complications including viral lower respiratory tract disease (LRTD) in hematopoietic cell transplantation (HCT) recipients. In this study, we examined whether antibiotic exposure was associated with increased risk of disease progression in RVIs post-transplantation...
May 16, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29777863/comparison-of-histological-and-morphometrical-changes-underlying-subchondral-bone-abnormalities-in-inflammatory-and-degenerative-musculoskeletal-disorders-a-systematic-review
#10
REVIEW
M Loef, S van Beest, F P B Kroon, J L Bloem, O M Dekkers, M Reijnierse, J W Schoones, M Kloppenburg
OBJECTIVE: Subchondral bone abnormalities (SBAs) on magnetic resonance imaging (MRI) are observed frequently and associated with disease course in various musculoskeletal disorders. This review aims to map the existing knowledge of their underlying histological features, and to identify needs for future research. DESIGN: We conducted a systematic review following PRISMA guidelines until September 2017, including all studies correlating histological features to on MRI defined SBAs in patients with osteoarthritis (OA), rheumatoid arthritis (RA), spondyloarthritis (SpA) and degenerative disc disease (DDD)...
May 16, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29777853/investigation-of-the-potential-endocrine-effect-of-nitrate-in-zebrafish-danio-rerio-and-brown-trout-salmo-trutta
#11
Poul Bjerregaard, Karin Lund Kinnberg, Maria Pedersen Mose, Henrik Holbech
Nitrate has the potential to affect steroid production. Nitrate concentrations in streams in agricultural areas may exceed concentrations showing effects in laboratory studies. The effects of nitrate and/or nitrite on endocrine relevant endpoints were tested in zebrafish and brown trout. Zebrafish were exposed in two experiments to nitrate (8.8 to 89 mg NO3 - /L) and nitrite (3.6 to 19 mg NO2 - /L) during the period of sexual differentiation and sex ratios were determined. Vitellogenin concentrations were determined in the second experiment...
May 16, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29777848/effects-on-mortality-and-cardiovascular-events-of-adherence-to-guideline-recommended-therapy-4-years-after-lower-extremity-arterial-revascularization
#12
M Thiney, N Della Schiava, R Ecochard, P Feugier, P Lermusiaux, A Millon, A Long
OBJECTIVES: All patients with lower extremity peripheral arterial disease (LE-PAD) should benefit from recommended pharmacologic therapies including antiplatelet agents, angiotensin converting enzyme inhibitors (ACE) or Angiotensin receptor blockers (ARB), and HMG-CoA-reductase inhibitors (statins). In the present study, this triple therapy was defined as the best medical treatment. This study was designed to determine the current risk for cardiovascular (CV) events and mortality and also to evaluate the effect of pharmacologic treatment on patient's survival, CV events and additional vascular surgery in vascularized LE-PAD patients...
May 16, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29777846/an-academic-tertiary-referral-center-s-experience-with-a-vascular-surgery-based-uterine-artery-embolization-program
#13
Naiem Nassiri, Adrian Balica, Nolan C Cirillo-Penn, Dustin Tyler Crystal, Gloria A Bachmann
OBJECTIVE: Despite growing endovascular experience within the vascular surgery community, some catheter-based interventions - such as uterine artery embolization (UAE) - remain outside the clinical scope of most vascular surgeons, owing in part to established referral patterns and limited awareness among referring colleagues. We present our experience with a vascular surgery-based, multidisciplinary UAE program at an academic tertiary referral center. METHODS: In a collaborative effort between vascular surgery and gynecology, a Pelvic Vascular Disease Program has been established to provide palliative, prophylactic, and therapeutic embolizations including, but not limited to, UAE...
May 16, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29777845/recanalization-after-endovenous-thermal-ablation
#14
Afsha Aurshina, Ahmad Alsheekh, Pavel Kibrik, Anil Hingorani, Natalie Marks, Enrico Ascher
OBJECTIVE: Endovenous thermal ablation in the form of radiofrequency ablation (RFA) or endovenous laser ablation (EVLA) has quickly ascended to a prime position in the treatment of venous insufficiency. While there is good data examining the rates of thrombotic complications, there is a relative paucity of data examining the recanalization rates after endovenous thermal ablation (ETA). METHODS: Data analysis was performed for 1475 thermal ablations in 485 patients from 2012-2015 as a retrospective chart review...
May 16, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29777840/negative-pressure-wound-therapy-to-promote-fixation-and-remodeling-of-omental-flap-in-patients-with-revascularized-limbs-a-case-series
#15
Nicla Settembre, Mario D'oria, Charbel Saba, Zakariyae Bouziane, Sergueï Malikov
We present our experience with five patients with CLTI treated with distal revascularization and omental flap coverage. We decided to investigate the efficacy and safety of NPWT (negative-pressure wound therapy) in promoting the fixation and remodeling of the omental flap as there is some evidence in the literature about the optimization of results for skin graft and dermal substitutes. Surgical revascularization was always the first procedure attempted; wound coverage was realized 3-5 days after the primary procedure (omental free-flap in three patients and omental flow-through flap in two patients)...
May 16, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29777827/is-reward-prediction-error-encoding-reliable-during-development
#16
Hanna Keren, Gang Chen, Brenda Benson, Monique Ernst, Ellen Leibenluft, Nathan A Fox, Daniel S Pine, Argyris Stringaris
Reward Prediction Errors (RPEs), defined as the difference between the expected and received outcomes, are integral to reinforcement learning models and play an important role in development and psychopathology. In humans, RPE encoding can be estimated using fMRI recordings, however, a basic measurement property of RPE signals, their test-retest reliability across different time scales, remains an open question. In this paper, we examine the 3-month and 3-year reliability of RPE encoding in youth (mean age at baseline = 10...
May 16, 2018: NeuroImage
https://www.readbyqxmd.com/read/29777825/the-temporal-evolution-of-conceptual-object-representations-revealed-through-models-of-behavior-semantics-and-deep-neural-networks
#17
B B Bankson, M N Hebart, I I A Groen, C I Baker
Visual object representations are commonly thought to emerge rapidly, yet it has remained unclear to what extent early brain responses reflect purely low-level visual features of these objects and how strongly those features contribute to later categorical or conceptual representations. Here, we aimed to estimate a lower temporal bound for the emergence of conceptual representations by defining two criteria that characterize such representations: 1) conceptual object representations should generalize across different exemplars of the same object, and 2) these representations should reflect high-level behavioral judgments...
May 16, 2018: NeuroImage
https://www.readbyqxmd.com/read/29777797/polypharmacy-defined-as-taking-five-or-more-drugs-is-inadequate-in-the-cardiovascular-setting
#18
Nazanin Abolhassani
BACKGROUND: By how much polypharmacy (defined by number of drugss) differs from polyactive ingredient use (defined by the number of pharmacologically active ingredients) has not been assessed. OBJECTIVES: to compare the extent of polypharmacy vs. polyactive ingredients among patients taking CV medicines. METHODS: Prospective, 10-year follow-up study conducted among 880 participants of the CoLaus study taking CV drugs at baseline. Polypharmacy was defined as the use of 5 or more CV medicines; polyactive ingredient use was defined as the use of 5 or more pharmacologically active CV ingredients...
May 16, 2018: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29777790/effect-of-intratesticular-hematoma-on-testis-microstructure-spermatogenesis-and-testosterone-production-defining-a-cut-off-point-for-significant-intratesticular-hematoma
#19
Alireza Aminsharifi, Alireza Monsef, Ali Noorafshan, Saied Karbalay-Doust, Zahra Jafarinezhad, Omid Koohi, Afshin Molaei
OBJECTIVES: To evaluate the effect of different degrees of intratesticular hematoma (ITH), a major consequence of blunt testis trauma, on testis microstructure and function. We determined a cut-off point for significant vs. nonsignificant ITH. METHODS: Seventy male rats were divided into 7 equal groups. The control group (G) remained intact. Sham groups consisted of rats given an intratesticular injection of normal saline in both testicles with volumes equivalent to 40% of testis volume (G-II), 30% (G-III) and 10% (G-IV)...
May 16, 2018: Urology
https://www.readbyqxmd.com/read/29777788/modified-transanosphincteric-york-mason-repair-of-non-radiated-rectourinary-fistulae-patient-reported-fecal-continence-outcomes
#20
Maxim J McKibben, Joceline S Fuchs, Alexander T Rozanski, Jeremy M Scott, Craig Olson, Farshid Araghizadeh, Allen F Morey
OBJECTIVES: To review our experience with the modified York Mason (MYM) procedure in treatment of rectourinary fistulae (RUF), and to assess fecal continence using patient reported measures. METHODS: Retrospective review was performed for patients who underwent MYM repair of non-radiated RUF with gluteal free fat graft from 2008 to 2016 at a single institution. Success was defined as resolution of fistula without need for further surgery. The Cleveland Clinic-Florida Wexner Fecal Incontinence Score (CCFFIS) and Patient Global Impression of Improvement (PGI-I) surveys were administered by phone...
May 16, 2018: Urology
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