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https://www.readbyqxmd.com/read/29149095/proton-nuclear-magnetic-resonance-%C3%A2-h-nmr-based-metabolomic-evaluation-of-human-renal-allografts-from-donations-after-circulatory-death
#1
Zijie Wang, Haiwei Yang, Chunchun Zhao, Jifu Wei, Junsong Wang, Zhijian Han, Jun Tao, Zhen Xu, Xiaobin Ju, Ruoyun Tan, Min Gu
BACKGROUND Delayed graft function (DGF) is a common complication that impairs allograft function after kidney transplantation. However, the mechanism of DGF remains unclear. Nuclear magnetic resonance (NMR)-based analysis has been widely used in recent times to assess changes in metabolite levels. MATERIAL AND METHODS Samples of perfusate from allografts donated after circulatory death were collected prior to transplantation, during static cold storage. ¹H-NMR-based metabolomics combined with the statistical methods, orthogonal partial least-squares discriminant analysis (OPLS-DA), and principle-component analysis (PCA), were employed to test different levels of metabolites between the allografts that exhibited DGF and those that exhibited immediate graft function (IGF)...
November 17, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29147472/recurrent-dyspnea-and-wheezing-pulmonary-function-test-and-dynamic-computed-tomography-may-unfold-the-diagnosis-of-tracheobronchomalacia
#2
REVIEW
Ashish Kumar Roy, Moni Roy, Ghaly Kerolus
Tracheomalacia patients often present with nonspecific symptoms like cough, wheezing and dyspnea. Tracheomalacia diagnosis is usually attributed to alternative common conditions such as asthma or chronic obstructive lung disease. Certain maneuvers, like forced expiration, or recumbent position may elicit subtle signs of tracheomalacia. Ordering novel pulmonary function testing in sitting upright and supine positions may provide additional clues to suspect tracheomalacia, which can be confirmed by either dynamic chest tomography or bronchoscopy...
2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29146301/association-of-sputum-and-blood-eosinophil-concentrations-with-clinical-measures-of-copd-severity-an-analysis-of-the-spiromics-cohort
#3
Annette T Hastie, Fernando J Martinez, Jeffrey L Curtis, Claire M Doerschuk, Nadia N Hansel, Stephanie Christenson, Nirupama Putcha, Victor E Ortega, Xingnan Li, R Graham Barr, Elizabeth E Carretta, David J Couper, Christopher B Cooper, Eric A Hoffman, Richard E Kanner, Eric Kleerup, Wanda K O'Neal, Richard Paine, Stephen P Peters, Neil E Alexis, Prescott G Woodruff, MeiLan K Han, Deborah A Meyers, Eugene R Bleecker
BACKGROUND: Increased concentrations of eosinophils in blood and sputum in chronic obstructive pulmonary disease (COPD) have been associated with increased frequency of exacerbations, reduced lung function, and corticosteroid responsiveness. We aimed to assess whether high eosinophil concentrations in either sputum or blood are associated with a severe COPD phenotype, including greater exacerbation frequency, and whether blood eosinophils are predictive of sputum eosinophils. METHODS: We did a multicentre observational study analysing comprehensive baseline data from SPIROMICS in patients with COPD aged 40-80 years who had a smoking history of at least 20 pack-years, recruited from six clinical sites and additional subsites in the USA between Nov 12, 2010, and April 21, 2015...
November 13, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29145288/efficacy-of-cold-application-on-pain-during-chest-tube-removal-a-randomized-controlled-trial-a-consort-compliant-article
#4
Ling-Yu Hsieh, Yi-Rong Chen, Mei-Chun Lu
BACKGROUND: Use of analgesics is the most common method to alleviate the pain induced by chest tube removal (CTR), but patient response to medication can vary and may not be achieved complete relaxation. This study was to determine the effectiveness of cold application in combination with standard analgesic administration before CTR on CTR-induced pain. METHODS: A prospective, randomized, single-blind, sham-controlled study was conducted. In addition to the same routine care, subjects in the experimental group (n = 30) received cold application of 600-g ice packs 15 minutes before CTR, whereas subjects in the sham group (n = 30) received tap water packs...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29144078/presence-of-household-mold-children-s-respiratory-health-and-school-absenteeism-cause-for-concern
#5
Eleoussa Polyzoi, Dimos Polyzois
A study examining the relationship between housing conditions, respiratory health, and school absenteeism was conducted in the city of Winnipeg in Manitoba, Canada. As part of this study, a survey was completed by 3,424 parents of children in grades 3 and 4 to determine the a) relationship between self-reported visible mold in homes and tested airborne mold; b) relationships of self-reported visible mold, tested airborne mold, and asthma and/or persistent colds; c) school absenteeism rates due to asthma and/or persistent colds; and d) children’s socioeconomic status (SES) and incidence of asthma and/or persistent colds...
March 2017: Journal of Environmental Health
https://www.readbyqxmd.com/read/29140896/cold-water-ingestion-improves-exercise-tolerance-of-heat-sensitive-people-with-ms
#6
Georgia K Chaseling, Davide Filingeri, Michael Barnett, Phu Hoang, Scott L Davis, Ollie Jay
PURPOSE: Heat intolerance commonly affects the exercise capacity of people with multiple sclerosis (MS) during bouts of hot weather. Cold-water ingestion is a simple cooling strategy but its efficacy for prolonging exercise capacity with MS remains undetermined. We sought to identify whether cold-water ingestion blunts exercise-induced rises in body temperature and improves exercise tolerance in heat-sensitive individuals with MS. METHODS: On two separate occasions, 20 participants (10 relapsing-remitting MS (EDSS: 1-5); 10 age-matched healthy controls (CON)) cycled at ~40% VO2max at 30°C, 30%RH until volitional exhaustion (or a maximum of 60 min)...
November 15, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29140491/validation-and-application-of-the-md-anderson-symptom-inventory-for-traditional-chinese-medicine-mdasi-tcm
#7
Zhandong Li, Qiuling Shi, Meng Liu, Liqun Jia, Bin He, Yufei Yang, Jie Liu, Hongsheng Lin, Huei-Kai Lin, Pingping Li, Xin Shelley Wang
Background: The MD Anderson Symptom Inventory (MDASI) is a brief, yet thorough, patient-reported outcomes measure for assessing the severity of common cancer-related symptoms and their interference with daily functioning. We report the development of an MDASI version tailored for use with Traditional Chinese Medicine in China (the MDASI-TCM). Methods: Chinese-speaking patients with mixed cancer types (n = 317) participated in the study. The development and validation process included four steps: 1) identify candidate TCM-specific items, with input from patients, oncologists, and TCM specialists; 2) eliminate candidate TCM items lacking relevance, based on patient report; 3) psychometrically examine the MDASI-TCM's validity and reliability in cancer patients receiving TCM-based care; and 4) cognitively debrief patients to assess the MDASI-TCM's relevance, understandability, and acceptability...
November 1, 2017: Journal of the National Cancer Institute. Monographs
https://www.readbyqxmd.com/read/29139249/-clinical-features-analysis-of-qingkailing-injection-for-adolescent-patients-based-on-real-world-his
#8
Li-Zhen Chen, Yan-Ming Xie, Lian-Xin Wang, Yin Zhang, Qun Wang, Ping-Ping Jia, Bo Feng
To explore the clinical application features of Qingkailing injection for adolescent patients. This study was based on the information from the hospitalized patients in 1998-2011 in HIS (hospital information system) of 16 tertiary hospitals in China. 615 adolescent patients with Qingkailing injection were used to investigate the clinical characteristics of Qingkailing injection. Apriori algorithm was adopted to establish the model, and Clementine 12.0 was used for correlation analysis. The results showed that male patients (355 cases) were more than female patients (243 cases); the age of the most patients was under 14 years old, with an average age of 9...
August 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29134013/southern-ocean-echinoids-database-an-updated-version-of-antarctic-sub-antarctic-and-cold-temperate-echinoid-database
#9
Salomé Fabri-Ruiz, Thomas Saucède, Bruno Danis, Bruno David
This database includes over 7,100 georeferenced occurrence records of sea urchins (Echinodermata: Echinoidea) obtained from samples collected in the Southern Ocean (+180°W/+180°E; -35°/-78°S) during oceanographic cruises led over 150 years, from 1872 to 2015. Echinoids are common organisms of Southern Ocean benthic communities. A total of 201 species is recorded, which display contrasting depth ranges and distribution patterns across austral provinces and bioregions. Echinoid species show various ecological traits including different nutrition and reproductive strategies...
2017: ZooKeys
https://www.readbyqxmd.com/read/29132060/traditional-beliefs-and-practices-in-pregnancy-childbirth-and-postpartum-a-review-of-the-evidence-from-asian-countries
#10
Mellissa Withers, Nina Kharazmi, Esther Lim
INTRODUCTION: Asian women suffer the largest proportion of the world's maternal deaths. To reduce this, policymakers and healthcare providers must encourage women with traditionally low rates of maternal health care utilization to access services. OBJECTIVE: The purpose of this study is to provide a comprehensive review of the most common traditional practices in Asia relating to pregnancy, childbirth and the postpartum period. DESIGN: We conducted a literature search of articles: a) focusing on Asia; b) relating to pregnancy, childbirth or postpartum, c) relating to traditional beliefs and/or cultural practices; and 4) published in English in the year 2000 or more recently...
November 10, 2017: Midwifery
https://www.readbyqxmd.com/read/29131867/differential-transcriptome-analysis-reveals-genes-related-to-cold-tolerance-in-seabuckthorn-carpenter-moth-eogystia-hippophaecolus
#11
Mingming Cui, Ping Hu, Tao Wang, Jing Tao, Shixiang Zong
Seabuckthorn carpenter moth, Eogystia hippophaecolus (Lepidoptera: Cossidae), is an important pest of sea buckthorn (Hippophae rhamnoides), which is a shrub that has significant ecological and economic value in China. E. hippophaecolus is highly cold tolerant, but limited studies have been conducted to elucidate the molecular mechanisms underlying its cold resistance. Here we sequenced the E. hippophaecolus transcriptome using RNA-Seq technology and performed de novo assembly from the short paired-end reads...
2017: PloS One
https://www.readbyqxmd.com/read/29128301/portal-vein-reconstruction-using-primary-anastomosis-or-venous-interposition-allograft-in-pancreatic-surgery
#12
Dyre Kleive, Audun Elnaes Berstad, Mushegh A Sahakyan, Caroline S Verbeke, Christian Naper, Sven Petter Haugvik, Ivar P Gladhaug, Pål-Dag Line, Knut Jørgen Labori
OBJECTIVE: Superior mesenteric vein/portal vein (SMV/PV) resection and reconstruction during pancreatic surgery are increasingly common. Several reconstruction techniques exist. The aim of this study was to evaluate characteristics of patients and clinical outcomes for SMV/PV reconstruction using interposed cold-stored cadaveric venous allograft (AG+) or primary end-to-end anastomosis (AG-) after segmental vein resections during pancreatic surgery. METHODS: All patients undergoing pancreatic surgery with SMV/PV resection and reconstruction from 2006 to 2015 were identified...
November 8, 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29125703/pharmacokinetics-and-safety-of-mavatrep-jnj-39439335-a-trpv1-antagonist-in-healthy-japanese-and-caucasian-men-a-double-blind-randomized-placebo-controlled-sequential-group-phase-1-study
#13
Prasarn Manitpisitkul, Kevin Shalayda, Lucille Russell, Panna Sanga, Bhavna Solanki, Joseph Caruso, Yuki Iwaki, John A Moyer
This single-center, double-blind, placebo-controlled, sequential-group phase 1 study evaluated the safety, tolerability, and pharmacokinetics (PK) of mavatrep (JNJ-39439335), a transient receptor potential vanilloid 1 antagonist, in healthy Japanese and caucasian subjects. In part 1, a single-ascending-dose study, 50 subjects (25 each healthy Japanese and caucasians) were enrolled and received a single oral dose of 10, 25, or 50 mg mavatrep. Caucasian subjects were matched to Japanese subjects with respect to age (±5 years) and body mass index (±5 kg/m(2) )...
November 10, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29123648/novel-therapeutic-approaches-to-simultaneously-target-rhinovirus-infection-and-asthma-copd-pathogenesis
#14
REVIEW
Carmen Mirabelli, Els Scheers, Johan Neyts
Rhinoviruses are exclusive respiratory pathogens and the etiological agents of the common cold. These viruses are increasingly reported to cause exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Here, we review the role of rhinovirus infections in the pathogenesis of asthma and COPD and we discuss the current and potential future treatments. We propose that, in order to prevent exacerbations, the design of novel therapeutics should focus on directly acting antivirals but also include the design of drugs that simultaneously inhibit viral replication and alleviate symptoms of asthma and COPD...
2017: F1000Research
https://www.readbyqxmd.com/read/29122558/optimal-housing-temperatures-for-mice-to-mimic-the-thermal-environment-of-humans-an%C3%A2-experimental-study
#15
Alexander W Fischer, Barbara Cannon, Jan Nedergaard
OBJECTIVES: The laboratory mouse is presently the most common model for examining mechanisms of human physiology and disease. Housing temperatures can have a large impact on the outcome of such experiments and on their translatability to the human situation. Humans usually create for themselves a thermoneutral environment without cold stress, while laboratory mice under standard conditions (≈20° C) are under constant cold stress. In a well-cited, theoretical paper by Speakman and Keijer in Molecular Metabolism, it was argued that housing mice under close to standard conditions is the optimal way of modeling the human metabolic situation...
October 31, 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29122343/seasonal-variations-of-nitrous-oxide-fluxes-and-soil-denitrification-rates-in-subtropical-freshwater-and-brackish-tidal-marshes-of-the-min-river-estuary
#16
Xuming Wang, Minjie Hu, Hongchang Ren, Jiabing Li, Chuan Tong, Ronald S Musenze
Estuarine tidal marshes provide favorable conditions for nitrous oxide (N2O) production. Saltwater intrusion caused by sea-level rise would exert complex effects on the production and emission of N2O in estuarine tidal marshes; however, few studies have been conducted on its effects on N2O emissions. Salinity gradients are a common occurrence in estuarine tidal marshes. Studies on production and emission of N2O in tidal marshes with different salinities may elucidate the impact of saltwater intrusion on the emission of greenhouse gases...
November 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29121109/itraq-based-quantitative-proteomic-analysis-in-vernalization-treated-faba-bean-vicia-faba-l
#17
Yun-Ying Cao, Xiao-Chun Bian, Mo-Xian Chen, Li-Ru Xia, Jianhua Zhang, Fu-Yuan Zhu, Chun-Fang Wu
Vernalization is classically defined as the induction of flowering process by exposure of the plants to a prolonged cold condition. Normally, it is considered as a precondition of flowering. Vicia faba, commonly known as faba bean, belongs to family Fabaceae. It is one of the plant species that has been cultivated in the earliest human settlements. In this study, an iTRAQ-LC-MS/MS-based quantitative proteomic analysis has been conducted to compare the vernalized faba bean seedlings and its corresponding control...
2017: PloS One
https://www.readbyqxmd.com/read/29120980/effect-of-cold-water-immersion-on-elbow-flexors-muscle-thickness-after-resistance-training
#18
Filipe Matos, Eduardo Borba Neves, Claudio Rosa, Victor Machado Reis, Francisco Saavedra, Severiano Silva, José Vilaça-Alves
Cold Water Immersion (CWI) is commonly applied in order to speed up the recovery process after exercise. Muscle damage may induce a performance reduction, consequence of the intramuscular pressure induced by the muscular swelling. The aim of the study was to verify the CWI effects on muscle thickness (MT) behavior of the elbow flexors after a strength training protocol (ST). Eleven males were submitted to a RT, performed in two different weeks. In one of the weeks, subjects experienced a passive recovery. In the other, subjects were submitted to a CWI (20 min at 5C-10°C)...
November 6, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29118465/antioxidant-and-anti-inflammatory-activities-in-extracts-from-minke-whale-balaenoptera-acutorostrata-blubber
#19
Mari Johannessen Walquist, Svein Kristian Stormo, Ida-Johanne Jensen, Bjarne Østerud, Karl-Erik Eilertsen
Intake of long-chain omega-3 polyunsaturated fatty acids (LC-n3-PUFA) is commonly recognized to reduce cardiovascular disease (CVD). In previous studies, cold-pressed whale oil (CWO) and cod liver oil (CLO) were given as a dietary supplement to healthy volunteers. Even though CWO contains less than half the amount of LC-n3-PUFA of CLO, CWO supplement resulted in beneficial effects on anti-inflammatory and CVD risk markers compared to CLO. In the present study, we prepared virtually lipid-free extracts from CWO and CLO and evaluated the antioxidative capacity (AOC) and anti-inflammatory effects...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29114561/awareness-about-rational-use-of-medicines-among-fresh-bachelor-of-medicine-and-bachelor-of-surgery-graduates
#20
Vijaya Laxman Chaudhari, Smita N Mali, Amruta V Dawari, Tushar B Nishandar
CONTEXT: Fresh Bachelor of Medicine and Bachelor of Surgery graduates (FMGs) are responsible for the majority of prescription errors and irrational use of medicines. Little research has explored their knowledge on rational prescribing practices. AIMS: The present study aimed to evaluate the awareness of rational use of medicines (RUMs) among the FMGs. SETTINGS AND DESIGN: A multicentric, cross-sectional, and questionnaire-based study was conducted among 308 FMGs during the internship orientation program...
2017: Journal of Education and Health Promotion
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