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https://www.readbyqxmd.com/read/28101593/diffuse-phalangeal-signal-abnormality-on-magnetic-resonance-imaging-phalangeal-microgeodic-disease
#1
Rupa Radhakrishnan, Kathleen H Emery, Arnold C Merrow
BACKGROUND: Phalangeal microgeodic disease is a rare and benign self-limited condition involving the phalanges, often in the setting of cold exposure, with characteristic MR imaging abnormalities. Radiographic case descriptions are predominantly from Asia and Europe, with only seven cases using MR to characterize phalangeal microgeodic disease. OBJECTIVE: In this study we describe the MR imaging appearance of unusual and striking phalangeal signal abnormality compatible with phalangeal microgeodic disease at our institution in North America...
January 18, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28100615/rhinovirus-c-asthma-and-cell-surface-expression-of-virus-receptor-cdhr3
#2
Ann C Palmenberg
Human rhinoviruses of the A, B, and C species are defined agents of the common cold. But more than that, the RV-A and RV-C are the dominant cause of hospitalization-category infections in young children, especially those with asthma. The RV-C use of cadherin-related family member 3 (CDHR3) as its cellular receptor, creates a direct phenotypic link between human genetics ("G" vs "A" alleles cause Cys529 vs Tyr529 protein variants) and the efficiency with which RV-C can infect cells. With a lower cell surface display density, the human-specific Cys529 variant apparently confers partial protection from the severest virus-induced asthma episodes...
January 18, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28100614/human-rhinovirus-diversity-and-evolution-how-strange-the-change-from-major-to-minor
#3
Nicole Lewis-Rogers, Jon Seger, Frederick R Adler
: Rhinoviruses are the most common cause of the common cold. Their many distinct lineages fall into "major" and "minor" groups that use different cell-surface receptors to enter host cells. Minor-group rhinoviruses are more immunogenic in laboratory studies, although their patterns of transmission and their cold symptoms are broadly similar to those of the major group. Here we present evolutionary evidence that minor-group viruses are also more immunogenic in humans. A key finding is that rates of amino-acid substitution at exposed sites in the capsid proteins VP2, VP3 and VP1 tend to be elevated in minor-group relative to major-group viruses, while rates at buried sites show no consistent differences...
January 18, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28097716/parental-knowledge-of-antibiotic-use-in-children-with-respiratory-infections-a-systematic-review
#4
REVIEW
Lourdes Cantarero-Arévalo, Mia Pavelics Hallas, Susanne Kaae
OBJECTIVE: Antimicrobial resistance (AMR) is an increasing global problem. AMR threatens the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses and fungi. The misuse and overuse of antibiotics (AB) is the major contributor to the emergence of resistant bacteria in humans. To present and describe characteristics in parents' knowledge about when and how to use AB for an upper respiratory tract infection (URTI), their attitudes towards doctors and AB use in general, and their behaviour when their child suffers from an URTI...
February 2017: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28097555/-protection-against-common-cold
#5
REVIEW
Martin Offenbächer, Annemarie Weber, Marcus van Dyck, Mara Taverna, Arndt Stahler, Niko Kohls, Jörg Schelling
No abstract text is available yet for this article.
January 2017: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/28097289/binding-of-cll-subset-4-b-cell-receptor-immunoglobulins-to-viable-human-memory-b-lymphocytes-requires-a-distinctive-igkv-somatic-mutation
#6
Rosa Catera, Yun Liu, Chao Gao, Xiao-Jie Yan, Amanda Magli, Steven L Allen, Jonathan E Kolitz, Kanti R Rai, Charles C Chu, Ten Feizi, Kostas Stamatopoulos, Nicholas Chiorazzi
Amino acid replacement mutations in certain CLL stereotyped B-cell receptor (BCR) immunoglobulins (IGs) at defined positions within antigen-binding sites strongly imply antigen selection. Prime examples of this are CLL subset 4 BCR IGs using IGHV4-34/IGHD5-18/IGHJ6 and IGKV2-30/IGKJ2 rearrangements. Conspicuously and unlike most CLL IGs, subset 4 IGs do not bind apoptotic cells. By testing the (auto)antigenic reactivities of subset 4 IGs toward viable lymphoid-lineage cells and specific autoantigens typically bound by IGHV4-34(+) IGs, we found IGs from both subset 4 and non-subset 4 IGHV4-34-expressing CLL cases bind naïve B cells...
January 12, 2017: Molecular Medicine
https://www.readbyqxmd.com/read/28096422/hydrogen-isotope-fractionation-in-methane-plasma
#7
François Robert, Sylvie Derenne, Guillaume Lombardi, Khaled Hassouni, Armelle Michau, Peter Reinhardt, Rémi Duhamel, Adriana Gonzalez, Kasia Biron
The hydrogen isotope ratio (D/H) is commonly used to reconstruct the chemical processes at the origin of water and organic compounds in the early solar system. On the one hand, the large enrichments in deuterium of the insoluble organic matter (IOM) isolated from the carbonaceous meteorites are interpreted as a heritage of the interstellar medium or resulting from ion-molecule reactions taking place in the diffuse part of the protosolar nebula. On the other hand, the molecular structure of this IOM suggests that organic radicals have played a central role in a gas-phase organosynthesis...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28088201/anti-allodynic-effect-of-buja-in-a-rat-model-of-oxaliplatin-induced-peripheral-neuropathy-via-spinal-astrocytes-and-pro-inflammatory-cytokines-suppression
#8
Yongjae Jung, Ji Hwan Lee, Woojin Kim, Sang Hyub Yoon, Sun Kwang Kim
BACKGROUND: Oxaliplatin, a widely used anticancer drug against metastatic colorectal cancer, can induce acute peripheral neuropathy, which is characterized by cold and mechanical allodynia. Activation of glial cells (e.g. astrocytes and microglia) and increase of pro-inflammatory cytokines (e.g. IL-1β and TNF-α) in the spinal cord play a crucial role in the pathogenesis of neuropathic pain. Our previous study demonstrated that Gyejigachulbu-Tang (GBT), a herbal complex formula, alleviates oxaliplatin-induced neuropathic pain in rats by suppressing spinal glial activation...
January 14, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28087169/antibiotic-knowledge-and-self-medication-practices-in-a-developing-country-a-cross-sectional-study
#9
Antoun Jamhour, Ammar El-Kheir, Pascale Salameh, Pierre Abi Hanna, Hanine Mansour
BACKGROUND: Self-medication is identified by the World Health Organization as a major factor leading to antibiotics overuse, misuse and resistance. This study's objectives were to evaluate the knowledge and self-medication with antibiotics in a sample of the population of Lebanon. METHODS: This study surveyed a sample of adults (over 18 years of age) residing in 2 major cities in Lebanon about their knowledge and self-medication with antibiotics. Health care professionals were excluded from the study...
January 11, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28086862/management-of-dentin-hypersensitivity-by-national-dental-practice-based-research-network-practitioners-results-from-a-questionnaire-administered-prior-to-initiation-of-a-clinical-study-on-this-topic
#10
Dorota T Kopycka-Kedzierawski, Cyril Meyerowitz, Mark S Litaker, Sidney Chonowski, Marc W Heft, Valeria V Gordan, Robin L Yardic, Theresa E Madden, Stephanie C Reyes, Gregg H Gilbert
BACKGROUND: Dentin hypersensitivity (DH) is a common problem encountered in clinical practice. The purpose of this study was to identify the management approaches for DH among United States dentists. METHODS: One hundred eighty five National Dental Practice-Based Research Network clinicians completed a questionnaire regarding their preferred methods to diagnose and manage DH in the practice setting, and their beliefs about DH predisposing factors. RESULTS: Almost all dentists (99%) reported using more than one method to diagnose DH...
January 13, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28077884/chemical-vs-physical-acceleration-of-cement-hydration
#11
Dale P Bentz, Franco Zunino, Didier Lootens
Cold weather concreting often requires the use of chemical accelerators to speed up the hydration reactions of the cement, so that setting and early-age strength development will occur in a timely manner. While calcium chloride (dihydrate - CaCl2·2H2O) is the most commonly used chemical accelerator, recent research using fine limestone powders has indicated their high proficiency for physically accelerating early-age hydration and reducing setting times. This paper presents a comparative study of the efficiency of these two approaches in accelerating hydration (as assessed via isothermal calorimetry), reducing setting times (Vicat needle), and increasing early-age mortar cube strength (1 d and 7 d)...
November 2016: Concr Int
https://www.readbyqxmd.com/read/28077878/pla2g16-represents-a-switch-between-entry-and-clearance-of-picornaviridae
#12
Jacqueline Staring, Eleonore von Castelmur, Vincent A Blomen, Lisa G van den Hengel, Markus Brockmann, Jim Baggen, Hendrik Jan Thibaut, Joppe Nieuwenhuis, Hans Janssen, Frank J M van Kuppeveld, Anastassis Perrakis, Jan E Carette, Thijn R Brummelkamp
Picornaviruses are a leading cause of human and veterinary infections that result in various diseases, including polio and the common cold. As archetypical non-enveloped viruses, their biology has been extensively studied. Although a range of different cell-surface receptors are bound by different picornaviruses, it is unclear whether common host factors are needed for them to reach the cytoplasm. Using genome-wide haploid genetic screens, here we identify the lipid-modifying enzyme PLA2G16 (refs 8, 9, 10, 11) as a picornavirus host factor that is required for a previously unknown event in the viral life cycle...
January 19, 2017: Nature
https://www.readbyqxmd.com/read/28068165/physiological-and-perceived-effects-of-forearm-or-head-cooling-during-simulated-firefighting-activity-and-rehabilitation
#13
Susan Yeargin, Amy L McKenzie, Lindsey E Eberman, J Derek Kingsley, David J Dziedzicki, Patrick Yoder
CONTEXT:  Cooling devices aim to protect firefighters by attenuating a rise in body temperature. Devices for head cooling (HC) while firefighting and forearm cooling (FC) during rehabilitation (RHB) intervals are commonly marketed, but research regarding their efficacy is limited. OBJECTIVE:  To investigate the physiological and perceived effects of HC and FC during firefighting drills and RHB. DESIGN:  Randomized controlled clinical trial...
November 2016: Journal of Athletic Training
https://www.readbyqxmd.com/read/28058767/do-group-dynamics-affect-colour-morph-clines-during-a-range-shift
#14
Lesley T Lancaster, Rachael Y Dudaniec, Bengt Hansson, Erik I Svensson
Species exhibiting colour-polymorphism are thought to have an ecological advantage at the landscape scale, because spatial segregation of alternatively-adapted ecotypes into diverse habitats can increase the total species' niche breadth and thus confer greater geographic range size. However, morph frequencies are also influenced by intra-populational processes such as frequency- or density-dependent social interactions. To identify how social feedback may affect clinal variation in morph frequencies, we investigated reciprocal interactions between morph-specific thermal tolerance, local climatic conditions, and social environments, in the context of a colour-morph frequency cline associated with a recent range expansion in blue-tailed damselflies (Ischnura elegans) in Sweden...
January 6, 2017: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/28057323/reconstruction-of-two-fingertip-amputations-using-a-double-thenar-flap-and-comparison-of-outcomes-of-surgery-using-a-single-thenar-flap
#15
Yu-Jun Kwon, Byung-Moon Ahn, Jae-Sung Lee, Yong-Gum Park, Hyun-Jun Ryu, Yong-Chan Ha
BACKGROUND: Although thenar flap for single fingertip amputation is a common and popular surgical technique, double thenar flap technique for patients with two fingertip amputations has rarely been reported in the literature. The purpose of this case-control study was to introduce the double thenar technique and compare the clinical outcomes between single thenar flap and double thenar flap surgical treatments. METHODS: From January 2005 to December 2014, 92 patients with single fingertip amputations were treated with thenar flap (Group I) and 28 patients with two fingertip amputations were treated with double thenar flap (Group II)...
December 28, 2016: Injury
https://www.readbyqxmd.com/read/28057058/efficacy-and-safety-of-lian-ju-gan-mao-capsules-for-treating-the-common-cold-with-wind-heat-syndrome-study-protocol-for-a-randomized-controlled-trial
#16
Shengjun Wang, Hongli Jiang, Qin Yu, Bin She, Bing Mao
BACKGROUND: The common cold is a common and frequent respiratory disease mainly caused by viral infection of the upper respiratory tract. Chinese herbal medicine has been increasingly prescribed to treat the common cold; however, there is a lack of evidence to support the wide utility of this regimen. This protocol describes an ongoing phase II randomized controlled clinical trial, based on the theory of traditional Chinese medicine (TCM), with the objective of evaluating the efficacy and safety of Lian-Ju-Gan-Mao capsules (LJGMC), a Chinese patent medicine, compared with placebo in patients suffering from the common cold with wind-heat syndrome (CCWHS)...
January 5, 2017: Trials
https://www.readbyqxmd.com/read/28056117/alopecia-following-bicoronal-incisions
#17
Sameep Kadakia, Arvind Badhey, Sara Ashai, Thomas S Lee, Yadranko Ducic
Importance: Multiple techniques may be used to perform bicoronal incisions, and alopecia is a known postoperative complication of this procedure. To date, no large studies exist comparing alopecia outcomes among bicoronal incision techniques with and without the use of Raney clips. Objective: To determine (1) whether postoperative alopecia is more common when bicoronal incisions are performed with monopolar cautery, Colorado microdissection tip cautery, or traditional cold steel and (2) whether this outcome is affected by the use of Raney clips...
January 5, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28054946/muscle-carnitine-palmitoyltransferase-ii-deficiency-a-review-of-enzymatic-controversy-and-clinical-features
#18
REVIEW
Diana Lehmann, Leila Motlagh, Dina Robaa, Stephan Zierz
CPT (carnitine palmitoyltransferase) II muscle deficiency is the most common form of muscle fatty acid metabolism disorders. In contrast to carnitine deficiency, it is clinically characterized by attacks of myalgia and rhabdomyolysis without persistent muscle weakness and lipid accumulation in muscle fibers. The biochemical consequences of the disease-causing mutations are still discussed controversially. CPT activity in muscles of patients with CPT II deficiency ranged from not detectable to reduced to normal...
January 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28053972/lower-extremity-and-carotid-artery-disease-in-copd
#19
Carmen Pizarro, Fabian Linnhoff, Fabian van Essen, Simon Pingel, Christian Alexander Schaefer, Nadjib Schahab, Rolf Fimmers, Georg Nickenig, Dirk Skowasch
In view of their common chronic inflammatory process, we sought to determine the linkage between peripheral artery disease and chronic obstructive pulmonary disease (COPD). 107 COPD patients (mean±sd age 64.6±10.4 years, 52.2% male) and 22 control smokers without previously diagnosed peripheral artery disease underwent standardised angiological examination for lower extremity artery disease (LEAD) and carotid artery disease. LEAD was significantly more prevalent in COPD patients than in controls (80.4% versus 54...
October 2016: ERJ Open Research
https://www.readbyqxmd.com/read/28052503/vulnerability-of-subarctic-and-arctic-breeding-birds
#20
Anouschka R Hof, Genoveva Rodríguez-Castañeda, Andrew M Allen, Roland Jansson, Christer Nilsson
Recent research predicts that future climate change will result in substantial biodiversity loss associated with loss of habitat for species. However, the magnitude of the anticipated biodiversity impacts are less well known. Studies of species vulnerability to climate change through species distribution models are often limited to assessing the extent of species' exposure to the consequences of climate change to their local environment, neglecting species sensitivity to global change. The likelihood that species or populations will decline or go extinct due to climate change also depends on the general sensitivity and adaptive capacity of species...
January 2017: Ecological Applications: a Publication of the Ecological Society of America
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