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https://www.readbyqxmd.com/read/29345355/effects-of-antioxidants-on-apoptosis-induced-by-dasatinib-and-nilotinib-in-k562-cells
#1
Sara Damiano, Serena Montagnaro, Maria Valeria Puzio, Lorella Severino, Ugo Pagnini, Marcella Barbarino, Daniele Cesari, Antonio Giordano, Salvatore Florio, Roberto Ciarcia
In clinical practice for the treatment of chronic myeloid leukemia, second generation of tyrosine kinase inhibitors such as Nilotinib (NIL) specific and potent inhibitor of the BCR/ABL kinase and Dasatinib (DAS) a inhibitor of BCR/ABL and Src family kinase were developed to clinically overcome imatinib resistance. In this study we wanted to test the ability of some antioxidants such Resveratrol (RES) or a new recombinant mitochondrial manganese containing superoxide dismutase (rMnSOD) or δ-tocotrienol (δ-TOCO) to interact with DAS and NIL on viability, reactive oxygen species (ROS) production, lipid peroxidation and apoptosis...
January 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29337368/stability-and-antioxidant-activity-of-annatto-bixa-orellana-l-tocotrienols-during-frying-and-in-fried-tortilla-chips
#2
Jill K Winkler-Moser, Erica L Bakota, Hong-Sik Hwang
Annatto tocotrienols (AnT3), which contain approximately 90% δ-tocotrienol (δ-T3), were added to mid-oleic sunflower oil used for frying tortilla chips over 3 d. The objectives were to evaluate their stability during frying, absorption by the fried food, and activity as antioxidants in frying oil and in tortilla chips during storage. AnT3 did not significantly affect the stability of the oil during frying or the sensory profiles of freshly fried chips. The naturally present α-tocopherol (α-T) in the oil degraded at a lower rate in the presence of AnT3, resulting in significantly higher α-T by the end of the frying study...
January 16, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29330573/tocotrienol-supplementation-suppressed-bone-resorption-and-oxidative-stress-in-postmenopausal-osteopenic-women-a-12-week-randomized-double-blinded-placebo-controlled-trial
#3
C-L Shen, S Yang, M D Tomison, A W Romero, C K Felton, H Mo
Tocotrienols have shown bone-protective effect in animals. This study showed that a 12-week tocotrienol supplementation decreased concentrations of bone resorption biomarker and bone remodeling regulators via suppressing oxidative stress in postmenopausal osteopenic women. INTRODUCTION: Tocotrienols (TT) have been shown to benefit bone health in ovariectomized animals, a model of postmenopausal women. The purpose of this study was to evaluate the effect of 12-week TT supplementation on bone markers (serum bone-specific alkaline phosphatase (BALP), urine N-terminal telopeptide (NTX), serum soluble receptor activator of nuclear factor-kappaB ligand (sRANKL), and serum osteoprotegerin (OPG)), urine calcium, and an oxidative stress biomarker (8-hydroxy-2'-deoxyguanosine (8-OHdG)) in postmenopausal women with osteopenia...
January 12, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29330434/targeting-melanoma-stem-cells-with-the-vitamin-e-derivative-%C3%AE-tocotrienol
#4
Monica Marzagalli, Roberta Manuela Moretti, Elio Messi, Marina Montagnani Marelli, Fabrizio Fontana, Alessia Anastasia, Maria Rosa Bani, Giangiacomo Beretta, Patrizia Limonta
The prognosis of metastatic melanoma is very poor, due to the development of drug resistance. Cancer stem cells (CSCs) may play a crucial role in this mechanism, contributing to disease relapse. We first characterized CSCs in melanoma cell lines. We observed that A375 (but not BLM) cells are able to form melanospheres and show CSCs traits: expression of the pluripotency markers SOX2 and KLF4, higher invasiveness and tumor formation capability in vivo with respect to parental adherent cells. We also showed that a subpopulation of autofluorescent cells expressing the ABCG2 stem cell marker is present in the A375 spheroid culture...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329846/nutritionally-enriched-1-3-diacylglycerol-rich-oil-low-calorie-fat-with-hypolipidemic-effects-in-rats
#5
B L A Prabhavathi Devi, K N Gangadhar, R B N Prasad, D Sugasini, Y Poorna Chandra Rao, B R Lokesh
An enzymatic process was developed for the preparation of a nutritionally enriched 1,3-diacylglycerol(DAG)-rich oil from a blend of refined sunflower and rice bran oils. The process involves hydrolysis of vegetable oil blend using Candida cylindracea followed by esterification with glycerol using Lipozyme RM1M. The resultant DAG-rich oil contains 84% of DAG (66% of 1,3-DAG, 18% of 1,2-DAG) and 16% of triacylglycerol (TAG) along with micro nutrients like γ-oryzanol, tocotrienols, tocopherols and phytosterols...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29315977/maize-w3-disrupts-homogentisate-solanesyl-transferase%C3%A2-zmhst-and-reveals-a-plastoquinone-9-independent-path-for-phytoene-desaturation-and-tocopherol-accumulation-in-kernels
#6
Charles T Hunter, Jonathan W Saunders, Maria Magallanes-Lundback, Shawn A Christensen, Denis Willett, Philip S Stinard, Qin-Bao Li, Kwanghee Lee, Dean DellaPenna, Karen E Koch
Maize white seedling 3 (w3) has been used to study carotenoid deficiency for almost 100 years, although the molecular basis of the mutation has remained unknown. Here we show that the w3 phenotype is caused by disruption of the maize gene for homogentisate solanesyl transferase (HST), which catalyzes the first and committed step in plastoquinone-9 (PQ-9) biosynthesis in the plastid. The resulting PQ-9 deficiency prohibits photosynthetic electron transfer and eliminates PQ-9 as an oxidant in the enzymatic desaturation of phytoene during carotenoid synthesis...
January 8, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29303614/red-palm-oil-supplementation-does-not-increase-blood-glucose-or-serum-lipids-levels-in-wistar-rats-with-different-thyroid-status
#7
H Rauchová, M Vokurková, S Pavelka, I Vaněčková, N Tribulová, T Soukup
Red palm oil (RPO) is a rich natural source of antioxidant vitamins, namely carotenes, tocopherols and tocotrienols. However, it contains approximately 50 % saturated fatty acids the regular consumption of which could negatively modify lipid profile. The aim of our study was to test whether 7 weeks of RPO supplementation (1 g/kg body weight/day) would affect blood glucose and lipid metabolism in adult male Wistar rats with altered thyroid status. We induced hypothyroidism and hyperthyroidism in rats by oral administration of either methimazole or mixture of thyroid hormones...
January 5, 2018: Physiological Research
https://www.readbyqxmd.com/read/29295607/vitamin-e-biosynthesis-and-its-regulation-in-plants
#8
REVIEW
Laurent Mène-Saffrané
Vitamin E is one of the 13 vitamins that are essential to animals that do not produce them. To date, six natural organic compounds belonging to the chemical family of tocochromanols-four tocopherols and two tocotrienols-have been demonstrated as exhibiting vitamin E activity in animals. Edible plant-derived products, notably seed oils, are the main sources of vitamin E in the human diet. Although this vitamin is readily available, independent nutritional surveys have shown that human populations do not consume enough vitamin E, and suffer from mild to severe deficiency...
December 25, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29283379/a-metabolomic-and-lipidomic-serum-signature-from-nonhuman-primates-administered-with-a-promising-radiation-countermeasure-gamma-tocotrienol
#9
Amrita K Cheema, Khyati Y Mehta, Oluseyi O Fatanmi, Stephen Y Wise, Charles P Hinzman, Josh Wolff, Vijay K Singh
The development of radiation countermeasures for acute radiation syndrome (ARS) has been underway for the past six decades, leading to the identification of multiple classes of radiation countermeasures. However, to date, only two growth factors (Neupogen and Neulasta) have been approved by the United States Food and Drug Administration (US FDA) for the mitigation of hematopoietic acute radiation syndrome (H-ARS). No radioprotector for ARS has been approved by the FDA yet. Gamma-tocotrienol (GT3) has been demonstrated to have radioprotective efficacy in murine as well as nonhuman primate (NHP) models...
December 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29261149/evaluation-of-biosynthesis-accumulation-and-antioxidant-activityof-vitamin-e-in-sweet-corn-zea-mays-l-during-kernel-development
#10
Lihua Xie, Yongtao Yu, Jihua Mao, Haiying Liu, Jian Guang Hu, Tong Li, Xinbo Guo, Rui Hai Liu
Sweet corn kernels were used in this research to study the dynamics of vitamin E, by evaluatingthe expression levels of genes involved in vitamin E synthesis, the accumulation of vitamin E, and the antioxidant activity during the different stage of kernel development. Results showed that expression levels of ZmHPT and ZmTC genes increased, whereas ZmTMT gene dramatically decreased during kernel development. The contents of all the types of vitamin E in sweet corn had a significant upward increase during kernel development, and reached the highest level at 30 days after pollination (DAP)...
December 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29225320/combination-effect-of-%C3%AE-tocotrienol-and-%C3%AE-tocopherol-on-prostate-cancer-cell-growth
#11
Chiaki Sato, Saki Kaneko, Ayami Sato, Nantiga Virgona, Kozue Namiki, Tomohiro Yano
Tocotrienols (T3s) and tocopherols (Tocs) are both members of the vitamin E family. It is known that δ-tocotrienol (δ-T3) has displayed the most potent anti-cancer activity amongst the tocotrienols. On the other hand, γ-tocopherol (γ-Toc) is reported to have a protective effect against prostate cancer. Therefore, we investigated whether the combination of γ-Toc and δ-T3 could strengthen the inhibitory effect of δ-T3 on prostate cancer cell growth. In this study the effect of combined δ-T3 (annatto T3 oil) and γ-Toc (Tmix, γ-Toc-rich oil) therapy was assessed against human androgen-dependent prostate cancer cells (LNCaP)...
2017: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/29217815/effects-of-nicotine-and-tocotrienol-rich-fraction-supplementation-on-cytoskeletal-structures-of-murine-pre-implantation-embryos
#12
Nurul Kamsani Hamirah, Yuhaniza Shafinie Kamsani, Nor-Ashikin Mohamed Nor Khan, Sharaniza Ab Rahim, Mohd Hamim Rajikin
BACKGROUND Cytoskeletal structures, in particular actin and tubulin, provide a fundamental framework in all cells, including embryos. The objective of this study was to evaluate the effects of nicotine, which is a source of oxidative stress, and subsequent supplementation with Tocotrienol-rich fraction (TRF) on actin and tubulin of 2- and 8-cell murine embryos. MATERIAL AND METHODS Thirty female Balb/C mice were divided into 4 groups: Group 1 received: subcutaneous (sc) injection of 0.9% NaCl; Group 2 received sc injection of 3...
December 8, 2017: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/29195915/development-and-in-vitro-characterization-of-nanoemulsions-loaded-with-paclitaxel-%C3%AE-tocotrienol-lipid-conjugates
#13
Ahmed Abu-Fayyad, Mohammad M Kamal, Jennifer L Carroll, Ana-Maria Dragoi, Robert Cody, James Cardelli, Sami Nazzal
Vitamin E TPGS is a tocopherol (α-T) based nonionic surfactant that was used in the formulation of the Tocosol™ paclitaxel nanoemulsion, which was withdrawn from phase III clinical trials. Unlike tocopherols, however, the tocotrienol (T3) isomers of vitamin E were found to have innate anticancer activity and were shown to potentiate the antitumor activity of paclitaxel. The primary objective of the present study was therefore to develop a paclitaxel nanoemulsions by substituting α-T oil core of Tocosol™ with γ-T3 in, and vitamin E TPGS with PEGylated γ-T3 as the shell, and test the nanoemulsions against Bx-PC-3 and PANC-1 pancreatic tumor cells...
November 30, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29194404/recent-advances-in-our-understanding-of-tocopherol-biosynthesis-in-plants-an-overview-of-key-genes-functions-and-breeding-of-vitamin-e-improved-crops
#14
REVIEW
Steffi Fritsche, Xingxing Wang, Christian Jung
Tocopherols, together with tocotrienols and plastochromanols belong to a group of lipophilic compounds also called tocochromanols or vitamin E. Considered to be one of the most powerful antioxidants, tocochromanols are solely synthesized by photosynthetic organisms including plants, algae, and cyanobacteria and, therefore, are an essential component in the human diet. Tocochromanols potent antioxidative properties are due to their ability to interact with polyunsaturated acyl groups and scavenge lipid peroxyl radicals and quench reactive oxygen species (ROS), thus protecting fatty acids from lipid peroxidation...
December 1, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29194360/the-modulation-of-nmda-and-ampa-kainate-receptors-by-tocotrienol-rich-fraction-and-%C3%AE-tocopherol-in-glutamate-induced-injury-of-primary-astrocytes
#15
Zahra Abedi, Huzwah Khaza'ai, Sharmili Vidyadaran, Mohd Sokhini Abd Mutalib
Astrocytes are known as structural and supporting cells in the central nervous system (CNS). Glutamate, as a main excitatory amino acid neurotransmitter in the mammalian central nervous system, can be excitotoxic, playing a key role in many chronic neurodegenerative diseases. The aim of the current study was to elucidate the potential of vitamin E in protecting glutamate-injured primary astrocytes. Hence, primary astrocytes were isolated from mixed glial cells of C57BL/6 mice by applying the EasySep® Mouse CD11b Positive Selection Kit, cultured in Dulbecco's modified Eagle medium (DMEM) and supplemented with special nutrients...
December 1, 2017: Biomedicines
https://www.readbyqxmd.com/read/29173163/tocopherol-and-tocotrienol-therapeutic-potential-in-animal-models-of-stress
#16
Mohd Fahami Nur Azlina, Yusof Kamisah, Mohd Saad Qodriyah
BACKGROUND: Scientific reports had shown that stress is related to numerous pathological changes in the body. These pathological changes can bring about numerous diseases and can significantly cause negative effects in an individual. These include gastric ulcer, liver pathology and neurobehavioral changes. A common pathogenesis in many diseases related to stress involves oxidative damage. Therefore, the administration of antioxidants such as vitamin E is a reasonable therapeutic approach...
November 22, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/29168797/role-of-vitamin-e-in-the-treatment-of-alzheimer-s-disease-evidence-from-animal-models
#17
REVIEW
Agnese Gugliandolo, Placido Bramanti, Emanuela Mazzon
Alzheimer's disease (AD) is a neurodegenerative disorder representing the major cause of dementia. It is characterized by memory loss, and cognitive and behavioral decline. In particular, the hallmarks of the pathology are amyloid-β (Aβ) plaques and neurofibrillary tangles (NFTs), formed by aggregated hyperphosphorylated tau protein. Oxidative stress plays a main role in AD, and it is involved in initiation and progression of AD. It is well known that Aβ induced oxidative stress, promoting reactive oxygen species (ROS) production and consequently lipid peroxidation, protein oxidation, tau hyperphosphorylation, results in toxic effects on synapses and neurons...
November 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29157827/supplementation-with-tocotrienols-from-bixa-orellana-improves-the-in-vivo-efficacy-of-daptomycin-against-methicillin-resistant-staphylococcus-aureus-in-a-mouse-model-of-infected-wound
#18
Elisa Pierpaoli, Fiorenza Orlando, Oscar Cirioni, Oriana Simonetti, Andrea Giacometti, Mauro Provinciali
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is a common cause of skin and soft-tissue infection worldwide. An adequate immune response acts as a first line of defence against infections and therefore plays an essential role in the maintenance of health. Tocotrienols (T3s), the lesser known isomers of vitamin E, possess many biological properties and have been recognized as immunomodulators. PURPOSE: The aim of this study was to investigate whether the in vivo supplementation with a mixture of 87...
December 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29156559/tocotrienols-a-family-of-molecules-with-specific-biological-activities
#19
REVIEW
Raffaella Comitato, Roberto Ambra, Fabio Virgili
Vitamin E is a generic term frequently used to group together eight different molecules, namely: α-, β-, γ- and δ-tocopherol and the corresponding tocotrienols. The term tocopherol and eventually Vitamin E and its related activity was originally based on the capacity of countering foetal re-absorption in deficient rodents or the development of encephalomalacia in chickens. In humans, Vitamin E activity is generally considered to be solely related to the antioxidant properties of the tocolic chemical structure...
November 18, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29147700/brown-rice-and-retrograded-brown-rice-alleviate-inflammatory-response-in-dextran-sulfate-sodium-dss-induced-colitis-mice
#20
Kemika Praengam, Yuraporn Sahasakul, Piengchai Kupradinun, Siriwan Sakarin, Wanwisa Sanitchua, Anudep Rungsipipat, Kasem Rattanapinyopituk, Pornpimon Angkasekwinai, Khaimuk Changsri, Wuttichai Mhuantong, Sithichoke Tangphatsornruang, Siriporn Tuntipopipat
The present study was aimed to investigate the impacts of brown rice (BR) and retrograded brown rice (R-BR) consumption on colonic health and gut microbiota in dextran sulfate sodium (DSS) induced colitis mice. Thirty two female C57Bl/6Mlac mice were fed with modified AIN 93G diets by replacing cornstarch in the original composition with white rice (WR), BR and R-BR powder. The mice were divided into 4 groups and fed with the following experimental diets for 4 weeks: (1) negative control (WR: diet with WR), (2) positive control (DSS_WR: DSS and diet with WR), (3) DSS_BR: DSS and diet with BR, and (4) DSS_R-BR: DSS and diet with R-BR...
November 17, 2017: Food & Function
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