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https://www.readbyqxmd.com/read/29925664/prolonged-evolution-of-virus-specific-memory-t-cell-immunity-post-severe-avian-influenza-a-h7n9-virus-infection
#1
Min Zhao, Junbo Chen, Shuguang Tan, Tao Dong, Hui Jiang, Jiandong Zheng, Chuansong Quan, Qiaohong Liao, Hangjie Zhang, Xiling Wang, Qianli Wang, Yuhai Bi, Fengfeng Liu, Luzhao Feng, Peter W Horby, Paul Klenerman, George F Gao, William J Liu, Hongjie Yu
Since 2013, influenza A/H7N9 has emerged as the commonest avian influenza subtype causing human infection, and is associated with a high fatality risk. However, the characteristics of immune memory in patients who have recovered from H7N9 infection are not well understood. We assembled a cohort of forty-five H7N9 survivors followed for up to 15 months after infection. Humoral and cellular immune responses were analyzed in sequential samples obtained at 1.5-4 months, 6-8 months and 12-15 months post-infection...
June 20, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29921685/stepped-wedge-cluster-randomised-controlled-trial-to-assess-the-effectiveness-of-an-optimisation-strategy-for-general-anaesthesia-on-postoperative-morbidity-and-mortality-in-elderly-patients-the-opti-aged-study-a-study-protocol
#2
Serge Molliex, Sylvie Passot, Emmanuel Futier, Marlène Bonnefoi, Florence Rancon, Yannick Lemanach, Bruno Pereira
INTRODUCTION: Elderly patients constitute an increasingly large proportion of the high-risk surgical group. In adult patients, several specific intraoperative approaches such as cardiac output-guided haemodynamic therapy, depth of anaesthesia monitoring (DAM) or lung-protective ventilation (LPV) are designed to reduce postoperative mortality and surgical complications. However, none of these approaches has been specifically performed in the elderly, and no evaluation of a multimodal optimisation strategy for general anaesthesia has been achieved in this population...
June 19, 2018: BMJ Open
https://www.readbyqxmd.com/read/29920361/wisp-3-ccn6-inhibits-apoptosis-by-regulating-caspase-pathway-after-hyperoxia-in-lung-epithelial-cells
#3
Shuquan Wei, Kangwei Wang, Zhuxiang Zhao, Xiaomei Huang, Wanna Tang, Ziwen Zhao
Cell death is a normal phenomenon in the course of biological development, moreover, which is also a prominent feature in lung exposed to hyperoxia. Severe hypoxia occurs in ALI/ARDS patients, who generally require high concentration oxygen therapy assisted by mechanical ventilation. Nevertheless, high oxygen can cause excessive reactive oxygen species (ROS), leading to apoptosis in lung epithelial cells, which has been reported in our previous study. Herein, the correlation between increments of ROS and CCN6 expression was negative in CCN6-mediated the mitochondria dependent, intrinsic apoptotic pathway...
June 16, 2018: Gene
https://www.readbyqxmd.com/read/29917290/hypoxic-pulmonary-vasoconstriction-in-isolated-mouse-pulmonary-arterial-vessels
#4
Ievgen Strielkov, Nicole Catherine Krause, Natasha Sommer, Ralph Theo Schermuly, Hossein Ardeschir Ghofrani, Friedrich Grimminger, Thomas Gudermann, Alexander Dietrich, Norbert Weissmann
NEW FINDINGS: What is the central question of this study? Hypoxic pulmonary vasoconstriction has never been characterized in isolated mouse pulmonary arteries of different generations in detail. What is the main finding and its importance? We found that only small intrapulmonary arteries (80 - 200 μm in diameter) exhibit hypoxic pulmonary vasoconstriction. The observed response was sustained, significantly potentiated by depolarization-induced preconstriction, and not dependent on endothelium and TRPC6 channels...
June 19, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29916009/lack-of-durable-protection-against-cotton-smoke-induced-acute-lung-injury-in-sheep-by-nebulized-single-chain-urokinase-plasminogen-activator-or-tissue-plasminogen-activator
#5
Satoshi Fukuda, Perenlei Enkhbaatar, Christina Nelson, Robert A Cox, Marla R Wolfson, Thomas H Shaffer, Robert O Williams, Soraya Hengsawas Surasarang, Sahakijpijarn Sawittree, Galina Florova, Andrey A Komissarov, Kathleen Koenig, Krishna Sarva, Harrison T Ndetan, Karan P Singh, Steven Idell
BACKGROUND: Airway fibrin casts are clinically important complications of severe inhalational smoke-induced acute lung injury (ISIALI) for which reliable evidence-based therapy is lacking. Nebulized anticoagulants or a tissue plasminogen activator; tPA, has been advocated, but airway bleeding is a known and lethal potential complication. We posited that nebulized delivery of single chain urokinase plasminogen activator, scuPA, is well-tolerated and improves physiologic outcomes in ISIALI...
June 18, 2018: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/29907273/extracorporeal-gas-exchange
#6
REVIEW
Onnen Moerer, Francesco Vasques, Eleonora Duscio, Francesco Cipulli, Federica Romitti, Luciano Gattinoni, Michael Quintel
Extracorporeal gas exchange is increasingly used for various indications. Among these are refractory acute respiratory failure, including the acute respiratory distress syndrome (ARDS), and the avoidance of ventilator-induced lung injury (VILI) by enabling lung-protective ventilation. Additionally, extracorporeal gas exchange allows the treatment of hypercapnic respiratory failure while helping to unload the respiratory muscles and avoid intubation and invasive ventilation, as well as facilitating weaning from the ventilator...
July 2018: Critical Care Clinics
https://www.readbyqxmd.com/read/29907270/avoiding-respiratory-and-peripheral-muscle-injury-during-mechanical-ventilation-diaphragm-protective-ventilation-and-early-mobilization
#7
REVIEW
Annia Schreiber, Michele Bertoni, Ewan C Goligher
Both limb muscle weakness and respiratory muscle weakness are exceedingly common in critically ill patients. Respiratory muscle weakness prolongs ventilator dependence, predisposing to nosocomial complications and death. Limb muscle weakness persists for months after discharge from intensive care and results in poor long-term functional status and quality of life. Major mechanisms of muscle injury include critical illness polymyoneuropathy, sepsis, pharmacologic exposures, metabolic derangements, and excessive muscle loading and unloading...
July 2018: Critical Care Clinics
https://www.readbyqxmd.com/read/29907082/paravertebral-dexmedetomidine-as-an-adjuvant-to-ropivacaine-protects-against-independent-lung-injury-during-one-lung-ventilation-a-preliminary-randomized-clinical-trial
#8
Wei Zhang, Shanfeng Zhang, Bing Li, Mingyang Sun, Jiaqiang Zhang
BACKGROUND: To investigate the effect of paravertebral dexmedetomidine as an adjuvant to ropivacaine on independent lung injury during one-lung ventilation. METHODS: In total, 120 patients who underwent elective radical resection of pulmonary carcinoma were randomly assigned to one of six groups (n = 20): normal saline (C group), ropivacaine (R group), intravenous dexmedetomidine (Div group), 0.5 μg/kg paravertebral dexmedetomidine as an adjuvant to ropivacaine (RD0...
June 15, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29906044/case-report-respiratory-syncytial-virus
#9
Rosalinda Jiménez-Aguilar, María Eugenia Rodriguez-Godoy, Rodolfo Norberto Jiménez-Juarez, María del Carmen Cano-Salas
Background: The Respiratory Syncytial Virus (RSV) is the most important viral pathogen in children under 2 years of age, which warrants hospitalization for a low respiratory infection. 0.5% of children under 5 with RSV infection require hospitalization. The aim of this case is to reaffirm the importance of this virus as a cause of severe disease and to emphasize the importance of adequate diagnosis and management to improve prognosis. Clinical case: Child of 1 year 3 months old, without risk factors for severe infection by respiratory viruses...
March 2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29902538/a-multicentre-observational-study-on-management-of-general-anaesthesia-in-elderly-patients-at-high-risk-of-postoperative-adverse-outcomes
#10
Serge Molliex, Sylvie Passot, Jerome Morel, Emmanuel Futier, Jean Yves Lefrant, Jean Michel Constantin, Yannick Le Manach, Bruno Pereira
INTRODUCTION: in elderly patients, goal directed haemodynamic therapy (GDHT), depth of anaesthesia monitoring and lung-protective ventilation have been shown to improve postoperative outcomes. The aim of this study was to evaluate current practices concerning strategies of anaesthesia optimisation in patients aged ≥ 75 years. PATIENTS AND METHODS: a multicentre observational study was performed from February to May 2015 in 23 French academic centres. On 30 consecutive days in each centre, patients ≥ 75 years with at least one major co-morbidity undergoing elective or emergency procedures (femoral-neck fractures surgery, intraperitoneal abdominal surgery or vascular surgery) were included...
June 11, 2018: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/29901798/the-use-of-extracorporeal-membrane-oxygenation-for-acute-respiratory-distress-syndrome-in-severe-burns-without-inhalation-injury
#11
Juliet J Ray, Richard J Straker, Valerie J Hart, Jonathan P Meizoso, Carl I Schulman, Matthias Loebe, Ali Ghodsizad
Burn injury results in a severe systemic inflammatory response which is associated with the development of acute respiratory distress syndrome (ARDS), even without associated inhalation injury. Venous-venous extracorporeal membrane oxygenation (VV-ECMO) has been implemented in various cases of ARDS to provide support and allow for protective lung ventilation strategies. We report the case of a 27-year-old man presenting with a 60% total body surface area partial thickness burn who developed refractory ARDS with Murray Score of 3...
June 13, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/29898436/endotracheal-intubation-and-in-hospital-mortality-after-intracerebral-hemorrhage
#12
Vasileios-Arsenios Lioutas, Sarah Marchina, Louis R Caplan, Magdy Selim, Joseph Tarsia, Luciana Catanese, Jonathan Edlow, Sandeep Kumar
BACKGROUND: Many patients with acute intracerebral hemorrhages (ICHs) undergo endotracheal intubation with subsequent mechanical ventilation (MV) for "airway protection" with the intent to prevent aspiration, pneumonias, and its related mortality. Conversely, these procedures may independently promote pneumonia, laryngeal trauma, dysphagia, and adversely affect patient outcomes. The net benefit of intubation and MV in this patient cohort has not been systematically investigated...
June 13, 2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29889963/are-the-king-lts-laryngeal-tube-and-the-ambu-auraonce-laryngeal-mask-useful-airway-adjuncts-for-military-medics
#13
Danny Regner, Peter Frykholm
BACKGROUND: Airway management is a critical skill that may be essential in the battlefield. The aim of this study was to determine if combat life savers and medics with no or limited clinical experience could provide airway control using the disposable laryngeal suction tube (LTS-D) and the Ambu® AuraOnce ™ disposable laryngeal mask (LMA). METHODS: Eight military medics with limited clinical experience and no airway management experience secured the airway on 19 intrahospital anesthetized patients using the LTS-D and the LMA...
2018: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/29888440/kawasaki-disease-shock-syndrome-a-unique-and-severe-subtype-of-kawasaki-disease
#14
Luisa Berenise Gamez-Gonzalez, Isabel Moribe-Quintero, Martin Cisneros-Castolo, Javier Varela-Ortiz, Mireya Muñoz-Ramírez, Martin Garrido-García, Marco Yamazaki-Nakashimada
BACKGROUND: Kawasaki disease shock syndrome (KDSS) is an uncommon presentation of Kawasaki disease (KD). KDSS has been associated with more severe markers of inflammation, coronary abnormalities and IVIG resistance. METHODS: A retrospective, descriptive study of children with KDSS in two hospitals was performed. Relevant articles about KD and shock were collected, demographic data, clinical presentation, laboratory variables, echocardiogram findings, treatment and special features were analyzed when available...
June 11, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29873109/assessment-of-chemical-and-microbiological-parameters-of-indoor-swimming-pool-atmosphere-using-multiple-comparisons
#15
Ana Rodríguez, Mercedes Tajuelo, Diana Rodríguez, Susana Seseña, Patricia Ruiz, Mª Llanos Palop
The aim of this study was to evaluate the air quality of an indoor swimming pool, analysing diurnal and seasonal variations in microbiological counts and chemical parameters. The results indicated that yeast and bacteria counts, as well as carbon dioxide (CO2 ), nitrogen oxides (NOx ) and O3 concentrations, showed significant diurnal difference. On the other hand, temperature, relative humidity (R.H.), yeast counts and concentrations of CO2 , particles, O3 , toluene, and benzene showed seasonal differences...
June 5, 2018: Indoor Air
https://www.readbyqxmd.com/read/29866205/effects-of-dexmedetomidine-on-delirium-duration-of-non-intubated-icu-patients-4d-trial-study-protocol-for-a-randomized-trial
#16
Clémence Louis, Thomas Godet, Gérald Chanques, Nathalie Bourguignon, Dominique Morand, Bruno Pereira, Jean-Michel Constantin
BACKGROUND: Delirium during intensive care unit (ICU) stay is frequent and associated with significant morbidity, mortality and healthcare-related costs. International guidelines suggest its prevention. However, curative treatment remains unclearly established. Despite contradictory and ambiguous academic literature, international guidelines suggest the use of second-generation (atypical) antipsychotics over haloperidol. However, haloperidol remains the most widely used neuroleptic worldwide as a first-line treatment of agitation and/or delirium...
June 4, 2018: Trials
https://www.readbyqxmd.com/read/29862257/alternative-and-natural-therapies-for-acute-lung-injury-and-acute-respiratory-distress-syndrome
#17
REVIEW
Vipul J Patel, Sreeja Biswas Roy, Hiren J Mehta, Myungsoo Joo, Ruxana T Sadikot
Introduction: Acute respiratory distress syndrome (ARDS) is a complex clinical syndrome characterized by acute inflammation, microvascular damage, and increased pulmonary vascular and epithelial permeability, frequently resulting in acute respiratory failure and death. Current best practice for ARDS involves "lung-protective ventilation," which entails low tidal volumes and limiting the plateau pressures in mechanically ventilated patients. Although considerable progress has been made in understanding the pathogenesis of ARDS, little progress has been made in the development of specific therapies to combat injury and inflammation...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29859667/comparison-of-modeled-estimates-of-inhalation-exposure-to-aerosols-during-use-of-consumer-spray-products
#18
Jihoon Park, Chungsik Yoon, Kiyoung Lee
In the field of exposure science, various exposure assessment models have been developed to complement experimental measurements; however, few studies have been published on their validity. This study compares the estimated inhaled aerosol doses of several inhalation exposure models to experimental measurements of aerosols released from consumer spray products, and then compares deposited doses within different parts of the human respiratory tract according to deposition models. Exposure models, including the European Center for Ecotoxicology of Chemicals Targeted Risk Assessment (ECETOC TRA), the Consumer Exposure Model (CEM), SprayExpo, ConsExpo Web and ConsExpo Nano, were used to estimate the inhaled dose under various exposure scenarios, and modeled and experimental estimates were compared...
May 30, 2018: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29859325/activation-of-akt-by-sc79-decreased-cerebral-infarct-in-early-cerebral-ischemia-reperfusion-despite-increased-bbb-disruption
#19
Xia Liu, Geza K Kiss, Scott J Mellender, Harvey R Weiss, Oak Z Chi
Activation of Akt has been suggested to produce neuronal protection in cerebral ischemia. Decreasing blood-brain barrier (BBB) disruption has been associated with a better neuronal outcome in cerebral ischemia. We hypothesized that activation of Akt would decrease BBB disruption and contribute to decreasing the size of infarct in the early stage of cerebral ischemia-reperfusion within the therapeutic window. Transient middle cerebral artery occlusion (MCAO) was performed in rats under isoflurane anesthesia with controlled ventilation...
May 30, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29851254/towards-informed-metrics-for-examining-the-role-of-human-induced-animal-responses-in-tag-studies-on-wild-animals
#20
Rory P Wilson, Mark Holton, Vianney L Wilson, Richard Gunner, Brenda Tysse, Gwendoline I Wilson, Flavio Quintana, Carlos Duarte, D Michael Scantlebury
Two prime issues can detrimentally affect animals that have been equipped with tags; (i) the effect of the capture and restraint process and (ii) the effect of the tag itself. This work examines some of the issues surrounding quantification of tag effects on wild animals for both restrained and free-living animals. A new method to quantify stress effects based on monitoring ventilation rates in relation to activity is suggested for restrained animals which may help improve the practice of handling animals. It is also suggested that various metrics, many derived from accelerometers, can be examined in tagged wild animals to examine the change in behaviours over time with a view to having a better understanding of welfare issues, assuring the quality of recorded data and informing best practice...
May 31, 2018: Integrative Zoology
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