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MicroRNA-181

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https://www.readbyqxmd.com/read/27889686/microrna-181-contributes-to-downregulation-of-samhd1-expression-in-cd4-t-cells-derived-from-s%C3%A3-zary-syndrome-patients
#1
Rebecca Kohnken, Karthik M Kodigepalli, Anjali Mishra, Pierluigi Porcu, Li Wu
Sézary syndrome (SS) is a rare subtype of cutaneous T-cell lymphoma (CTCL) that is characterized by aggressive spread of neoplastic CD4+ T-cells from the skin into the bloodstream with metastasis to visceral organs. The deoxynucleoside triphosphohydrolase SAMHD1 is highly expressed in normal CD4+ T-cells, while its expression is down-regulated in CD4+ T-cells from SS patients. MicroRNA (miR) dysregulation is an important epigenetic mechanism in the pathogenesis and progression of SS. MiR-181 has been shown to inhibit SAMHD1 expression in cell lines and was identified as an important prognostic biomarker in CTCL...
November 17, 2016: Leukemia Research
https://www.readbyqxmd.com/read/27698792/expression-of-microrna-181-determines-response-to-treatment-with-azacitidine-and-predicts-survival-in-elderly-patients-with-acute-myeloid-leukaemia
#2
Aleksandra Butrym, Justyna Rybka, Dagmara Baczyńska, Rafał Poręba, Grzegorz Mazur, Kazimierz Kuliczkowski
MicroRNAs (miRs) are small non-coding RNAs that play important roles in cell differentiation and survival. Abnormal expression of miRs has been demonstrated in numerous types of cancer, including acute myeloid leukaemia (AML). The aim of the present study was to evaluate miR-181 expression at diagnosis and following the completion of chemotherapy in AML patients, with regard to clinical response and outcome, particularly in patients treated with azacitidine. miR-181 expression was analysed using reverse transcription-quantitative polymerase chain reaction in 95 bone marrow specimens from newly diagnosed AML patients and in 20 healthy subjects for comparison...
October 2016: Oncology Letters
https://www.readbyqxmd.com/read/27017280/microrna-181-promotes-synaptogenesis-and-attenuates-axonal-outgrowth-in-cortical-neurons
#3
Aron Kos, Nikkie Olde Loohuis, Julia Meinhardt, Hans van Bokhoven, Barry B Kaplan, Gerard J Martens, Armaz Aschrafi
MicroRNAs (miRs) are non-coding gene transcripts abundantly expressed in both the developing and adult mammalian brain. They act as important modulators of complex gene regulatory networks during neuronal development and plasticity. miR-181c is highly abundant in cerebellar cortex and its expression is increased in autism patients as well as in an animal model of autism. To systematically identify putative targets of miR-181c, we repressed this miR in growing cortical neurons and found over 70 differentially expressed target genes using transcriptome profiling...
September 2016: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/26722250/microrna-181a-enhances-the-chemotherapeutic-sensitivity-of-chronic-myeloid-leukemia-to-imatinib
#4
Guangyu Wang, Ran Zhao, Xingsheng Zhao, X I Chen, Dong Wang, Yinji Jin, X I Liu, C I Zhao, Yuanyuan Zhu, Chengcheng Ren, Minghui Li, Xiaoming Jin, Fengmin Zhang, Zhaohua Zhong, Tianzhen Wang, Xiaobo Li
MicroRNA-181 (miR-181) has been recently demonstrated to participate in the differentiation and development of immune cells, including natural killer cells and B and T lymphocytes, and myeloid linages, including erythroid and megakaryocytic cells. The aberrant expression of miR-181, particularly low expression levels, has been observed in a number of leukemia types, including B-cell chronic lymphocytic leukemia and cytogenetically abnormal acute myeloid leukemia. However, the expression and function of miR-181 in chronic myeloid leukemia (CML) remains unknown...
November 2015: Oncology Letters
https://www.readbyqxmd.com/read/26376228/prognostic-significance-of-npm1-mutation-modulated-microrna-mrna-regulation-in-acute-myeloid-leukemia
#5
Y-C Chiu, M-H Tsai, W-C Chou, Y-C Liu, Y-Y Kuo, H-A Hou, T-P Lu, L-C Lai, Y Chen, H-F Tien, E Y Chuang
Distinct microRNA (miRNA) and mRNA signatures were reported in nucleophosmin (NPM1)-mutated acute myeloid leukemia (AML). However, it remains unknown whether the mutation participates in the dynamic interaction between miRNA and mRNA. In this study, we aimed to investigate the role of NPM1 mutation in modulating miRNA-mRNA regulation (MMR). From the sample-paired miRNA/mRNA microarrays of 181 de novo AML patients, we found that MMR was dynamic and could be affected by NPM1 mutation. By a systematic framework, we identified 493 NPM1 mutation-modulated MMR pairs, where the strength of MMR was significantly attenuated in patients carrying NPM1 mutations, compared to those with wild-type NPM1...
February 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/26363800/short-interspersed-dna-elements-and-mirnas-a-novel-hidden-gene-regulation-layer-in-zebrafish
#6
Margherita Scarpato, Claudia Angelini, Ennio Cocca, Maria M Pallotta, Maria A Morescalchi, Teresa Capriglione
In this study, we investigated by in silico analysis the possible correlation between microRNAs (miRNAs) and Anamnia V-SINEs (a superfamily of short interspersed nuclear elements), which belong to those retroposon families that have been preserved in vertebrate genomes for millions of years and are actively transcribed because they are embedded in the 3' untranslated region (UTR) of several genes. We report the results of the analysis of the genomic distribution of these mobile elements in zebrafish (Danio rerio) and discuss their involvement in generating miRNA gene loci...
September 2015: Chromosome Research
https://www.readbyqxmd.com/read/26276790/impaired-vascular-function-and-repair-in-patients-with-premature-coronary-artery-disease
#7
Mairi Brittan, Amanda Hunter, Mounia Boulberdaa, Takeshi Fujisawa, Elizabeth M Skinner, Anoop Sv Shah, Andrew H Baker, Nicholas L Mills
BACKGROUND: Endothelial dysfunction is central to the pathogenesis of coronary artery disease, but the role of local and circulating endothelial progenitor cells in maintaining vascular health is poorly understood. We hypothesised that impaired local and circulating vascular repair mechanisms predispose to endothelial dysfunction and the premature onset of coronary artery disease. METHODS AND RESULTS: Patients with premature coronary artery disease (n = 16) and healthy age- and sex-matched controls (n = 16) underwent venous occlusion plethysmography with intra-arterial infusion of acetylcholine and sodium nitroprusside...
December 2015: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/26252355/surgery-induced-weight-loss-is-associated-with-the-downregulation-of-genes-targeted-by-micrornas-in-adipose-tissue
#8
Francisco J Ortega, Josep M Mercader, José M Moreno-Navarrete, Lara Nonell, Eulàlia Puigdecanet, José I Rodriquez-Hermosa, Oscar Rovira, Gemma Xifra, Ester Guerra, María Moreno, Dolores Mayas, Natalia Moreno-Castellanos, José A Fernández-Formoso, Wifredo Ricart, Francisco J Tinahones, David Torrents, María M Malagón, José M Fernández-Real
CONTEXT: Molecular mechanisms associated with physiological variations in adipose tissue (AT) are not fully recognized. The most recent reports highlight the critical relevance of microRNAs (miRNAs) found in AT. OBJECTIVE: To identify changes in messenger RNA (mRNA) and miRNA expressions and their interaction in human AT before and after surgery-induced weight loss. Research Design and Setting: Genome-wide mRNA and miRNA expressions were assessed by microarrays in abdominal subcutaneous AT of 16 morbidly obese women before and 2 years after laparoscopic Roux-en-Y gastric bypass...
November 2015: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26230660/circulating-micrornas-as-biomarkers-of-adult-crohn-s-disease
#9
Michael D Jensen, Rikke F Andersen, Henry Christensen, Torben Nathan, Jens Kjeldsen, Jonna S Madsen
OBJECTIVE: Previous studies have found a differential expression of microRNAs (miRNAs) in the blood of patients with Crohn's disease (CD) compared with healthy controls. The aim of this study was to identify circulating miRNAs expressed in CD and assess their performance as biomarkers in patients with clinically suspected or known CD. METHODS: The study consisted of two parts: (a) miRNA profiling: The miRNA expression pattern was examined in six patients with CD and six controls using OpenArray miRNA profiling, and the best miRNAs were selected according to their P-value...
September 2015: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/26104160/small-rnas-in-metastatic-and-non-metastatic-oral-squamous-cell-carcinoma
#10
Patricia Severino, Liliane Santana Oliveira, Flávia Maziero Andreghetto, Natalia Torres, Otávio Curioni, Patricia Maluf Cury, Tatiana Natasha Toporcov, Alexandre Rossi Paschoal, Alan Mitchell Durham
BACKGROUND: Small non-coding regulatory RNAs control cellular functions at the transcriptional and post-transcriptional levels. Oral squamous cell carcinoma is among the leading cancers in the world and the presence of cervical lymph node metastases is currently its strongest prognostic factor. In this work we aimed at finding small RNAs expressed in oral squamous cell carcinoma that could be associated with the presence of lymph node metastasis. METHODS: Small RNA libraries from metastatic and non-metastatic oral squamous cell carcinomas were sequenced for the identification and quantification of known small RNAs...
2015: BMC Medical Genomics
https://www.readbyqxmd.com/read/26059339/genome-wide-identification-of-the-phaseolus-vulgaris-srnaome-using-small-rna-and-degradome-sequencing
#11
Damien Formey, Luis Pedro Iñiguez, Pablo Peláez, Yong-Fang Li, Ramanjulu Sunkar, Federico Sánchez, José Luis Reyes, Georgina Hernández
BACKGROUND: MiRNAs and phasiRNAs are negative regulators of gene expression. These small RNAs have been extensively studied in plant model species but only 10 mature microRNAs are present in miRBase version 21, the most used miRNA database, and no phasiRNAs have been identified for the model legume Phaseolus vulgaris. Thanks to the recent availability of the first version of the common bean genome, degradome data and small RNA libraries, we are able to present here a catalog of the microRNAs and phasiRNAs for this organism and, particularly, we suggest new protagonists in the symbiotic nodulation events...
2015: BMC Genomics
https://www.readbyqxmd.com/read/26032093/expressions-of-mir-181a-and-mir-20a-in-rpmi8226-cell-line-and-their-potential-as-biomarkers-for-multiple-myeloma
#12
Jing Peng, Asmitananda Thakur, Shuo Zhang, Yuanfeng Dong, Xiaoqin Wang, Ruili Yuan, Kaige Zhang, Xuan Guo
Multiple myeloma (MM) is characterized by clonal proliferation of malignant plasma cells in the bone marrow. The anti-tumor activity of bortezomib (a proteosome inhibitor) in MM is challenged by emergence of drug resistance. MicroRNAs (miR) regulate and orchestrate multiple cellular pathways. We investigate the contribution miR-181a and miR-20a expressions' on cell proliferation and apoptosis in RPMI8226 cell line and their influence on bortezomib treatment. RNA isolation, quantitative real-time PCR (qRT-PCR), cell proliferation assay, cell cycle analysis, and cell apoptosis assay were done...
November 2015: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/25984438/interleukin-6-and-microrna-profiles-induced-by-oral-bacteria-in-human-atheroma-derived-and-healthy-smooth-muscle-cells
#13
Tanja Pessi, Leena E Viiri, Emma Raitoharju, Nagora Astola, Ilkka Seppälä, Melanie Waldenberger, Kari Lounatmaa, Alun H Davies, Terho Lehtimäki, Pekka J Karhunen, Claudia Monaco
BACKGROUND: Atherosclerosis is an inflammatory disease with possible contributions from bacterial antigens. We aimed to investigate the role of oral bacteria as inducers of inflammatory cascades in smooth muscle cells from carotid endarterectomy patients (AthSMCs) and healthy controls (HSMCs). FINDINGS: Inactivated Streptococcus mitis, S. sanguinis, S. gorgonii, Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis were used to stimulate inflammation in HSMCs and AthSMCs...
2015: SpringerPlus
https://www.readbyqxmd.com/read/25976622/serum-mir-181b-is-correlated-with-hepatitis-b-virus-replication-and-disease-progression-in-chronic-hepatitis-b-patients
#14
Fujun Yu, Guangyao Zhou, Guojun Li, Bicheng Chen, Peihong Dong, Jianjian Zheng
BACKGROUND: Previously, we reported that microRNA-181b (miR-181b) activates hepatic stellate cells partly through the phosphatase and tensin homolog deleted on chromosome 10 (PTEN)/Akt pathway. AIMS: The main objective of this study was to ascertain whether serum miR-181b expression is correlated with that of liver hepatitis B virus (HBV) DNA and disease progression in chronic hepatitis B (CHB) patients. METHODS: Serum miR-181b and liver HBV DNA levels were quantified in 64 CHB patients with real-time PCR...
August 2015: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/25915705/microrna-levels-as-prognostic-markers-for-the-differentiation-potential-of-human-mesenchymal-stromal-cell-donors
#15
Nicole Georgi, Hanna Taipaleenmaki, Christian C Raiss, Nathalie Groen, Karolina Janaeczek Portalska, Clemens van Blitterswijk, Jan de Boer, Janine N Post, Andre J van Wijnen, Marcel Karperien
The ability of human mesenchymal stromal/stem cells (hMSCs) to differentiate into various mesenchymal cell lineages makes them a promising cell source for the use in tissue repair strategies. Since the differentiation potential of hMSCs differs between donors, it is necessary to establish biomarkers for the identification of donors with high differentiation potential. In this study, we show that microRNA (miRNA) expression levels are effective for distinguishing donors with high differentiation potential from low differentiation potential...
August 15, 2015: Stem Cells and Development
https://www.readbyqxmd.com/read/25856466/let-7-mir-98-and-mir-183-as-biomarkers-for-cancer-and-schizophrenia-corrected
#16
Emmanouil Rizos, Nikolaos Siafakas, Eleni Katsantoni, Eleni Skourti, Vassilios Salpeas, Ioannis Rizos, James N Tsoporis, Anastasia Kastania, Anastasia Filippopoulou, Nikolaos Xiros, Demetrios Margaritis, Thomas G Parker, Charalabos Papageorgiou, Vassilios Zoumpourlis
Recent evidence supports a role of microRNAs in cancer and psychiatric disorders such as schizophrenia and bipolar disorder, through their regulatory role on the expression of multiple genes. The rather rare co-morbidity of cancer and schizophrenia is an old hypothesis which needs further research on microRNAs as molecules that might exert their oncosuppressive or oncogenic activity in the context of their role in psychiatric disorders. The expression pattern of a variety of different microRNAs was investigated in patients (N = 6) suffering from schizophrenia termed control, patients with a solid tumor (N = 10) and patients with both schizophrenia and tumor (N = 8)...
2015: PloS One
https://www.readbyqxmd.com/read/25829219/rapid-and-sensitive-detection-of-multiple-micrornas-in-cell-lysate-by-low-fouling-surface-plasmon-resonance-biosensor
#17
Hana Vaisocherová, Hana Šípová, Ivana Víšová, Markéta Bocková, Tomáš Špringer, Maria Laura Ermini, Xue Song, Zdeněk Krejčík, Leona Chrastinová, Ondřej Pastva, Kristýna Pimková, Michaela Dostálová Merkerová, Jan E Dyr, Jiří Homola
We report an ultra-low fouling surface plasmon resonance imaging (SPRi) biosensor for the rapid simultaneous detection of multiple miRNAs in erythrocyte lysate (EL) at subpicomolar levels without need of RNA extraction. The SPRi chips were coated with ultra-low fouling functionalizable poly(carboxybetaine acrylamide) (pCBAA) brushes having optimized thicknesses and directly functionalized with amino-modified oligonucleotide probes. We have characterized the effect of the brush thickness on the probe loading capacity: a loading capacity of ~9...
August 15, 2015: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/25727520/gsk3-inhibitors-chir99021-and-6-bromoindirubin-3-oxime-inhibit-microrna-maturation-in-mouse-embryonic-stem-cells
#18
Yongyan Wu, Fayang Liu, Yingying Liu, Xiaolei Liu, Zhiying Ai, Zekun Guo, Yong Zhang
Wnt/β-catenin signalling plays a prominent role in maintaining self-renewal and pluripotency of mouse embryonic stem cells (mESCs). microRNAs (miRNAs) have critical roles in maintaining pluripotency and directing reprogramming. To investigate the effect of GSK3 inhibitors on miRNA expression, we analysed the miRNA expression profile of J1 mESCs in the absence or presence of CHIR99021 (CHIR) or 6-bromoindirubin-3'-oxime (BIO) by small RNA deep-sequencing. The results demonstrate that CHIR and BIO decrease mature miRNAs of most miRNA species, 90...
2015: Scientific Reports
https://www.readbyqxmd.com/read/25724393/pre-and-post-natal-muscle-microrna-expression-profiles-of-two-pig-breeds-differing-in-muscularity
#19
COMPARATIVE STUDY
Puntita Siengdee, Nares Trakooljul, Eduard Murani, Bodo Brand, Manfred Schwerin, Klaus Wimmers, Siriluck Ponsuksili
miRNAs regulate the expression of target genes in diverse cellular processes and hence play important roles in physiological processes including developmental timing, patterning, embryogenesis, organogenesis, cell lineage, myogenesis and growth control. A comparative expression analysis of miRNAs expressed in the longissimus dorsi muscle at two prenatal stages (63 and 91 days post-conception (dpc)), and one adult stage (180 days post-natum) in both German Landrace (DL) and Pietrain (Pi) pig breeds was performed using a custom-designed array...
May 1, 2015: Gene
https://www.readbyqxmd.com/read/25688981/next-generation-sequencing-identifies-deregulation-of-micrornas-involved-in-both-innate-and-adaptive-immune-response-in-alk-alcl
#20
Julia Steinhilber, Michael Bonin, Michael Walter, Falko Fend, Irina Bonzheim, Leticia Quintanilla-Martinez
Anaplastic large cell lymphoma (ALCL) is divided into two systemic diseases according to the expression of the anaplastic lymphoma kinase (ALK). We investigated the differential expression of miRNAs between ALK+ ALCL, ALK- ALCL cells and normal T-cells using next generation sequencing (NGS). In addition, a C/EBPβ-dependent miRNA profile was generated. The data were validated in primary ALCL cases. NGS identified 106 miRNAs significantly differentially expressed between ALK+ and ALK- ALCL and 228 between ALK+ ALCL and normal T-cells...
2015: PloS One
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