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Jacob vigil

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https://www.readbyqxmd.com/read/29761126/seronegative-antibody-mediated-neurology-after-immune-checkpoint-inhibitors
#1
Robert Wilson, David A Menassa, Alexander J Davies, Sophia Michael, Joanna Hester, Wilhelm Kuker, Graham P Collins, Judith Cossins, David Beeson, Neil Steven, Paul Maddison, Simon Rinaldi, Saiju Jacob, Sarosh R Irani
Checkpoint inhibitor medications have revolutionized oncology practice, but frequently induce immune-related adverse events. During autoimmune neurology practice over 20 months, we prospectively identified four patients with likely antibody-mediated neurological diseases after checkpoint inhibitors: longitudinally extensive transverse myelitis, Guillain-Barré syndrome, and myasthenia gravis. All patients shared three characteristics: symptoms commenced 4 weeks after drug administration, responses to conventional immunotherapies were excellent, and autoantibodies traditionally associated with their syndrome were absent...
May 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29623144/accuracy-of-patient-opioid-use-reporting-at-the-time-of-medical-cannabis-license-renewal
#2
Jacob M Vigil, Sarah S Stith, Anthony P Reeve
The decision to authorize a patient for continued enrollment in a state-sanctioned medical cannabis program is difficult in part due to the uncertainty in the accuracy of patient symptom reporting and health functioning including any possible effects on other medication use. We conducted a pragmatic convenience study comparing patient reporting of previous and current prescription opioid usage to the opioid prescription records in the Prescription Monitoring Program (PMP) among 131 chronic pain patients (mean age = 54; 54% male) seeking the first annual renewal of their New Mexico Medical Cannabis Program (NMMCP) license...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29531724/fatal-cardiac-arrhythmia-caused-by-tumor-lysis-in-a-patient-with-diffuse-large-b-cell-lymphoma-upon-start-of-r-chop
#3
Nina Sørensen, Paw Jensen, Erik Clasen-Linde, Jacob Moesgaard Larsen, Tarec El-Galaly
Tumor lysis syndrome is rare in diffuse large cell lymphoma, but it is important to recognize the risk in patients with massive tumor burden and reduced kidney function. Very intense vigilance can be necessary despite adequate prophylactic measures and certain drugs may exacerbate electrolyte derangements.
March 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29476688/mental-health-related-emergency-department-visits-associated-with-cannabis-in-colorado
#4
Katelyn E Hall, Andrew A Monte, Tae Chang, Jacob Fox, Cody Brevik, Daniel I Vigil, Mike Van Dyke, Katherine A James
BACKGROUND: Cannabis legalization in Colorado resulted in increased cannabis-associated health care utilization. Our objective was to examine cooccurrence of cannabis and mental health diagnostic coding in Colorado emergency department (ED) discharges and replicate the study in a subpopulation of ED visits where cannabis involvement and psychiatric diagnosis were confirmed through medical review. METHODS: We collected statewide ED International Classification of Diseases, 9th Revision, Clinical Modification diagnoses from the Colorado Hospital Association and a subpopulation of ED visits from a large, academic hospital from 2012 to 2014...
February 24, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29465354/self-reported-childhood-maltreatment-lifelong-traumatic-events-and-mental-disorders-in-american-and-israeli-rheumatoid-arthritis-patients
#5
Rona Merdler-Rabinowicz, Ayal Hassidim, Raneen Hellou, Ilan Merdler, Winfried Hauser, Jacob N Ablin
OBJECTIVES: Psychological stress is thought to play a major role in the development and exacerbation of autoimmune diseases in general, as well as in rheumatoid arthritis (RA) in particular. The aims of the current study are to compare retrospective self-reports of childhood maltreatment and lifetime major life/traumatic experiences of American and Israeli RA patients, using standardised instruments, while adjusting for concomitant mental disorders and psychological distress, in order to rule out their part in the subjective reports, thus addressing the trans-cultural robustness of the association between childhood maltreatment, traumatic experiences and RA...
February 15, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29464421/two-inhibitors-of-yeast-plasma-membrane-atpase-1-scpma1p-toward-the-development-of-novel-antifungal-therapies
#6
Sabine Ottilie, Gregory M Goldgof, Andrea L Cheung, Jennifer L Walker, Edgar Vigil, Kenneth E Allen, Yevgeniya Antonova-Koch, Carolyn W Slayman, Yo Suzuki, Jacob D Durrant
Given that many antifungal medications are susceptible to evolved resistance, there is a need for novel drugs with unique mechanisms of action. Inhibiting the essential proton pump Pma1p, a P-type ATPase, is a potentially effective therapeutic approach that is orthogonal to existing treatments. We identify NSC11668 and hitachimycin as structurally distinct antifungals that inhibit yeast ScPma1p. These compounds provide new opportunities for drug discovery aimed at this important target.
February 20, 2018: Journal of Cheminformatics
https://www.readbyqxmd.com/read/29430941/the-not-so-global-blood-oxygen-level-dependent-signal
#7
Jacob Billings, Shella Keilholz
Global signal regression is a controversial processing step for resting-state functional magnetic resonance imaging, partly because the source of the global blood oxygen level-dependent (BOLD) signal remains unclear. On the one hand, nuisance factors such as motion can readily introduce coherent BOLD changes across the whole brain. On the other hand, the global signal has been linked to neural activity and vigilance levels, suggesting that it contains important neurophysiological information and should not be discarded...
April 2018: Brain Connectivity
https://www.readbyqxmd.com/read/29226697/update-on-the-use-of-direct-oral-anticoagulants-for-the-prevention-and-treatment-of-thromboembolism
#8
Anna Jacobs, Rajesh Kabra, Pranab Das, Carrie S Oliphant
Following publication of our review article 4 years ago, there has been an uptake in the use of nonvitamin K oral antagonists, also known as direct oral anticoagulants. The most recent Xa inhibitors to receive approval are edoxaban, which has been approved for use in both atrial fibrillation and venous thromboembolism prevention and betrixaban, which has been approved in the USA for extended thromboprophylaxis in the medically ill population. Additional analyses of certain types of atrial fibrillation patients have now become available...
January 2018: Future Cardiology
https://www.readbyqxmd.com/read/29154954/the-impact-of-social-exclusion-on-anticipatory-attentional-processing
#9
John E Kiat, Jacob E Cheadle, Bridget J Goosby
The importance of understanding how we anticipate and prepare for social rejection is underscored by the mental and physical toll of continual social vigilance. In this study, we investigate the impact of social rejection on anticipatory attentional processes using the well-known Cyberball task, a paradigm in which participants engage in a game of catch with virtual avatars who after an initial period of fair-play (inclusion condition) then exclude the participant from the game (exclusion condition). The degree of anticipatory attention allocated by subjects towards the avatars was assessed by measuring P3b responses towards the avatars' preparatory actions (i...
January 2018: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29145417/associations-between-medical-cannabis-and-prescription-opioid-use-in-chronic-pain-patients-a-preliminary-cohort-study
#10
Jacob M Vigil, Sarah S Stith, Ian M Adams, Anthony P Reeve
BACKGROUND: Current levels and dangers of opioid use in the U.S. warrant the investigation of harm-reducing treatment alternatives. PURPOSE: A preliminary, historical, cohort study was used to examine the association between enrollment in the New Mexico Medical Cannabis Program (MCP) and opioid prescription use. METHODS: Thirty-seven habitual opioid using, chronic pain patients (mean age = 54 years; 54% male; 86% chronic back pain) enrolled in the MCP between 4/1/2010 and 10/3/2015 were compared to 29 non-enrolled patients (mean age = 60 years; 69% male; 100% chronic back pain)...
2017: PloS One
https://www.readbyqxmd.com/read/28899660/effects-of-legal-access-to-cannabis-on-scheduled-ii-v-drug-prescriptions
#11
Sarah S Stith, Jacob M Vigil, Ian Marshall Adams, Anthony P Reeve
BACKGROUND: Co-prescribing of scheduled drugs is endemic in the United Sates, increasing health risks to patients and the burden on healthcare systems. PURPOSE: We conducted a pragmatic historical cohort study to measure the effect of enrollment in a state-authorized United States' Medical Cannabis Program (MCP) on scheduled II-V drug prescription patterns. PROCEDURES: Eighty-three chronic pain patients, who enrolled in the New Mexico MCP between April 1, 2010 and October 3, 2015, were compared with 42 nonenrolled patients over a 24-month period (starting 6 months before enrollment for the MCP patients) using the Prescription Monitoring Program...
January 2018: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28866027/cortisol-treatment-affects-locomotor-activity-and-swimming-behaviour-of-male-smallmouth-bass-engaged-in-paternal-care-a-field-study-using-acceleration-biologgers
#12
Dirk A Algera, Jacob W Brownscombe, Kathleen M Gilmour, Michael J Lawrence, Aaron J Zolderdo, Steven J Cooke
Paternal care, where the male provides sole care for the developing brood, is a common form of reproductive investment among teleost fish and ubiquitous in the Centrarchidae family. Throughout the parental care period, nesting males expend energy in a variety of swimming behaviours, including routine and burst swimming, vigilantly monitoring the nest area and protecting the brood from predators. Parental care is an energetically demanding period, which is presumably made even more difficult if fish are exposed to additional challenges such as those arising from human disturbance, resulting in activation of the hypothalamic-pituitary-interrenal axis (i...
November 1, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28775068/active-sleep-unmasks-apnea-and-delayed-arousal-in-infant-rat-pups-lacking-central-serotonin
#13
Jacob O Young, Aron Geurts, Matthew R Hodges, Kevin J Cummings
Sudden infant death syndrome (SIDS), occurring during sleep periods, is highly associated with abnormalities within serotonin (5-HT) neurons, including reduced 5-HT. There is evidence that future SIDS cases experience more apnea and have abnormal arousal from sleep. In rodents, a loss of 5-HT neurons is associated with apnea in early life and, in adulthood, delayed arousal. As the activity of 5-HT neurons changes with vigilance state, we hypothesized that the degree of apnea and delayed arousal displayed by rat pups specifically lacking central 5-HT varies with state...
October 1, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28466195/beneficial-neurocognitive-effects-of-transcranial-laser-in-older-adults
#14
Enrique Vargas, Douglas W Barrett, Celeste L Saucedo, Li-Da Huang, Jacob A Abraham, Hirofumi Tanaka, Andreana P Haley, F Gonzalez-Lima
Transcranial infrared laser stimulation (TILS) at 1064 nm, 250 mW/cm(2) has been proven safe and effective for increasing neurocognitive functions in young adults in controlled studies using photobiomodulation of the right prefrontal cortex. The objective of this pilot study was to determine whether there is any effect from TILS on neurocognitive function in older adults with subjective memory complaint at risk for cognitive decline (e.g., increased carotid artery intima-media thickness or mild traumatic brain injury)...
July 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28187101/how-nurse-gender-influences-patient-priority-assignments-in-us-emergency-departments
#15
Jacob Miguel Vigil, Patrick Coulombe, Joe Alcock, Sarah See Stith, Eric Kruger, Sara Cichowski
The goals of this study were to compare whether emergency department (ED) patients' pain intensity (PI) is measured differently by male and female nurses and to determine whether PI, heart rate (HR), and respiratory rate (RR) were used to prioritize patient urgency differently by male and female nurses. The associations between patients' PI|HR|RR and the Emergency Severity Index (ESI) scores they were assigned by attending nurses were analyzed using a national database of electronic medical records of US Veterans Affairs ED patients from 2008 to 2012...
March 2017: Pain
https://www.readbyqxmd.com/read/28041629/prevalence-of-and-outcomes-from-staphylococcus-aureus-pneumonia-among-hospitalized-patients-in-the-united-states-2009-2012
#16
David M Jacobs, Amy Shaver
BACKGROUND: The burden of Staphylococcus aureus pneumonia is unknown despite being a major cause of mortality. We investigated national estimates of methicillin-resistant S aureus (MRSA) and methicillin-susceptible S aureus (MSSA) pneumonias and predictors of in-hospital mortality and hospital length of stay (LOS). METHODS: This was a retrospective analysis of the National Inpatient Sample from 2009-2012. Adult patients with an ICD-9-CM primary diagnosis code for MRSA or MSSA pneumonia were included...
April 1, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/27977118/rapid-chagas-disease-drug-target-discovery-using-directed-evolution-in-drug-sensitive-yeast
#17
Sabine Ottilie, Gregory M Goldgof, Claudia Magalhaes Calvet, Gareth K Jennings, Greg LaMonte, Jake Schenken, Edgar Vigil, Prianka Kumar, Laura-Isobel McCall, Eduardo Soares Constantino Lopes, Felicia Gunawan, Jennifer Yang, Yo Suzuki, Jair L Siqueira-Neto, James H McKerrow, Rommie E Amaro, Larissa M Podust, Jacob D Durrant, Elizabeth A Winzeler
Recent advances in cell-based, high-throughput phenotypic screening have identified new chemical compounds that are active against eukaryotic pathogens. A challenge to their future development lies in identifying these compounds' molecular targets and binding modes. In particular, subsequent structure-based chemical optimization and target-based screening require a detailed understanding of the binding event. Here, we use directed evolution and whole-genome sequencing of a drug-sensitive S. cerevisiae strain to identify the yeast ortholog of TcCyp51, lanosterol-14-alpha-demethylase (TcCyp51), as the target of MMV001239, a benzamide compound with activity against Trypanosoma cruzi, the etiological agent of Chagas disease...
February 17, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/27626904/pediatric-pituitary-resection-characterizing-surgical-approaches-and-complications
#18
Curtis Hanba, Peter F Svider, Mahdi A Shkoukani, Anthony Sheyn, Jeffrey T Jacob, Jean Anderson Eloy, Adam J Folbe
BACKGROUND: Although there has been extensive study evaluating adult pituitary surgery, there has been scant analysis among children. Our objective was to evaluate a population-based resource to characterize nationwide trends in surgical approach, hospital stay, and complications among children undergoing pituitary surgery. METHODS: The Kids' Inpatient-Database (KID) files (2009/2012) were evaluated for pituitary gland excisions. Procedure, patient demographics, length of inpatient stay, inpatient costs, hospital setting, and surgical complications were analyzed...
January 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27625490/anesthesia-for-peroral-endoscopic-myotomy-a-retrospective-case-series
#19
Nithin Jayan, Jaya Susan Jacob, Mohan Mathew, Roy Joy Mukkada
BACKGROUND AND AIMS: Peroral endoscopic myotomy (POEM) is a safe and minimally invasive modality regarded as the first-line management of all types of achalasia. POEM is performed under general anesthesia with endotracheal intubation using an orally inserted flexible fiberscope. The aim of this study is to describe the anesthetic management of POEM for achalasia. MATERIAL AND METHODS: A chart review of 21 patients who underwent POEM for achalasia at our center from March 2013 to June 2015 was performed...
July 2016: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/27562441/does-ultrasociality-really-exist%C3%A2-%C3%A2-and-is-it-the-best-predictor-of-human-economic-behaviors
#20
Sarah S Stith, Jacob M Vigil
We agree that human economic structures can be informed by comparative analyses; however, we do not agree with several of Gowdy & Krall's specific assertions, which may hinder the generative potential of their model. We discuss these limitations from both biological and economic perspectives, and offer an alternative explanation for the expression of human economic behaviors based on individual optimization strategies.
January 2016: Behavioral and Brain Sciences
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