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Jacob vigil

Jacob Miguel Vigil, Patrick Coulombe, Joe Alcock, Sarah See Stith, Eric Kruger, Sara Cichowski
The goals of this study were to compare whether emergency department (ED) patients' pain intensity (PI) is measured differently by male and female nurses and to determine whether PI, heart rate (HR), and respiratory rate (RR) were used to prioritize patient urgency differently by male and female nurses. The associations between patients' PI|HR|RR and the Emergency Severity Index (ESI) scores they were assigned by attending nurses were analyzed using a national database of electronic medical records of US Veterans Affairs ED patients from 2008 to 2012...
March 2017: Pain
David M Jacobs, Amy Shaver
BACKGROUND: The burden of Staphylococcus aureus pneumonia is unknown despite being a major cause of mortality. We investigated national estimates of methicillin-resistant S aureus (MRSA) and methicillin-susceptible S aureus (MSSA) pneumonias and predictors of in-hospital mortality and hospital length of stay (LOS). METHODS: This was a retrospective analysis of the National Inpatient Sample from 2009-2012. Adult patients with an ICD-9-CM primary diagnosis code for MRSA or MSSA pneumonia were included...
December 30, 2016: American Journal of Infection Control
Sabine Ottilie, Gregory M Goldgof, Claudia Magalhaes Calvet, Gareth K Jennings, Greg LaMonte, Jake Schenken, Edgar Vigil, Prianka Kumar, Laura-Isobel McCall, Eduardo Soares Constantino Lopes, Felicia Gunawan, Jennifer Yang, Yo Suzuki, Jair L Siqueira-Neto, James H McKerrow, Rommie E Amaro, Larissa M Podust, Jacob D Durrant, Elizabeth A Winzeler
Recent advances in cell-based, high-throughput phenotypic screening have identified new chemical compounds that are active against eukaryotic pathogens. A challenge to their future development lies in identifying these compounds' molecular targets and binding modes. In particular, subsequent structure-based chemical optimization and target-based screening require a detailed understanding of the binding event. Here, we use directed evolution and whole-genome sequencing of a drug-sensitive S. cerevisiae strain to identify the yeast ortholog of TcCyp51, lanosterol-14-alpha-demethylase (TcCyp51), as the target of MMV001239, a benzamide compound with activity against Trypanosoma cruzi, the etiological agent of Chagas disease...
February 17, 2017: ACS Chemical Biology
Curtis Hanba, Peter F Svider, Mahdi A Shkoukani, Anthony Sheyn, Jeffrey T Jacob, Jean Anderson Eloy, Adam J Folbe
BACKGROUND: Although there has been extensive study evaluating adult pituitary surgery, there has been scant analysis among children. Our objective was to evaluate a population-based resource to characterize nationwide trends in surgical approach, hospital stay, and complications among children undergoing pituitary surgery. METHODS: The Kids' Inpatient-Database (KID) files (2009/2012) were evaluated for pituitary gland excisions. Procedure, patient demographics, length of inpatient stay, inpatient costs, hospital setting, and surgical complications were analyzed...
January 2017: International Forum of Allergy & Rhinology
Nithin Jayan, Jaya Susan Jacob, Mohan Mathew, Roy Joy Mukkada
BACKGROUND AND AIMS: Peroral endoscopic myotomy (POEM) is a safe and minimally invasive modality regarded as the first-line management of all types of achalasia. POEM is performed under general anesthesia with endotracheal intubation using an orally inserted flexible fiberscope. The aim of this study is to describe the anesthetic management of POEM for achalasia. MATERIAL AND METHODS: A chart review of 21 patients who underwent POEM for achalasia at our center from March 2013 to June 2015 was performed...
July 2016: Journal of Anaesthesiology, Clinical Pharmacology
Sarah S Stith, Jacob M Vigil
We agree that human economic structures can be informed by comparative analyses; however, we do not agree with several of Gowdy & Krall's specific assertions, which may hinder the generative potential of their model. We discuss these limitations from both biological and economic perspectives, and offer an alternative explanation for the expression of human economic behaviors based on individual optimization strategies.
January 2016: Behavioral and Brain Sciences
Jacob M Vigil, Eric Kruger
Pain suffering has been naturally selected to be experienced and expressed within a wider social system. The communication of pain improves group coordination and decision-making about engaging in resource dependent and potentially risky endeavors. Recent findings warrant the development of a cohesive framework for understanding the reciprocal nature of pain expression and individual and group-level outcomes that can generate novel predictions on the heuristical expression of human suffering in naturalistic and clinical settings...
January 2016: Behavioral and Brain Sciences
Judy G Johnson, Jacob P Bray, William H Risher, Alan David Kaye
Loeys-Dietz syndrome (LDS) is a rare autosomal dominant disease related to genetic mutations in receptors for the cytokine transforming growth factor-receptor type 1 (TGFB-R1) or 2 gene (TGFB-R2) on the cell surface. LDS results in abnormal protein synthesis and dysfunctional connective tissue, which can result in unique cardiovascular anesthesia challenges related to perioperative management. Patients with LDS may manifest hypertelorism, bifid uvula or cleft palate, and arterial tortuosity. Virtually all LDS patients show some type of abnormal skin findings and bleeding tendency...
June 2016: Middle East Journal of Anesthesiology
Jacob N Ablin, Iris Eshed, Mark Berman, Valerie Aloush, Irena Wigler, Dan Caspi, Maria Likhter, Jonathan Wollman, Daphna Paran, Marina Anouk, Ori Elkayam
Objective To evaluate the prevalence of sacroiliitis, the radiographic hallmark of inflammatory spondyloarthropathy, among patients diagnosed with the fibromyalgia syndrome, using the current ASAS criteria and MR imaging. Methods Patients suffering from FMS (ACR 1990 criteria) were interviewed regarding presence of SpA features and underwent HLA-B27 testing, CRP measurement and MRI examinations of the sacro-iliac joints. FMS severity was assessed by the FIQ and SF-36 questionnaires. SpA severity was assessed by the BASDAI...
July 7, 2016: Arthritis Care & Research
Joseph R Kapurch, Jeffrey T Jacob, Matthew L Carlson, John L Atkinson, Aditya Raghunathan, Michael J Link
OBJECTIVE: Secondary tumorigenesis after exposure to ionizing radiation is a well-described phenomenon. The probability of developing a malignancy after stereotactic radiosurgery (SRS) is theoretically less than conventional external beam radiation therapy; however, the exact risk remains unknown. Such information is important for patient counseling when considering treatment of benign conditions such as vestibular schwannoma (VS). The objective of the current report is to describe a case of a temporal lobe gliosarcoma developing 3 years after radiosurgical treatment of a sporadic VS...
September 2016: Otology & Neurotology
Gregory M Goldgof, Jacob D Durrant, Sabine Ottilie, Edgar Vigil, Kenneth E Allen, Felicia Gunawan, Maxim Kostylev, Kiersten A Henderson, Jennifer Yang, Jake Schenken, Gregory M LaMonte, Micah J Manary, Ayako Murao, Marie Nachon, Rebecca Stanhope, Maximo Prescott, Case W McNamara, Carolyn W Slayman, Rommie E Amaro, Yo Suzuki, Elizabeth A Winzeler
The spiroindolones, a new class of antimalarial medicines discovered in a cellular screen, are rendered less active by mutations in a parasite P-type ATPase, PfATP4. We show here that S. cerevisiae also acquires mutations in a gene encoding a P-type ATPase (ScPMA1) after exposure to spiroindolones and that these mutations are sufficient for resistance. KAE609 resistance mutations in ScPMA1 do not confer resistance to unrelated antimicrobials, but do confer cross sensitivity to the alkyl-lysophospholipid edelfosine, which is known to displace ScPma1p from the plasma membrane...
2016: Scientific Reports
Michael Jacobs, Alison Rodger, David J Bell, Sanjay Bhagani, Ian Cropley, Ana Filipe, Robert J Gifford, Susan Hopkins, Joseph Hughes, Farrah Jabeen, Ingolfur Johannessen, Drosos Karageorgopoulos, Angie Lackenby, Rebecca Lester, Rebecca S N Liu, Alisdair MacConnachie, Tabitha Mahungu, Daniel Martin, Neal Marshall, Stephen Mepham, Richard Orton, Massimo Palmarini, Monika Patel, Colin Perry, S Erica Peters, Duncan Porter, David Ritchie, Neil D Ritchie, R Andrew Seaton, Vattipally B Sreenu, Kate Templeton, Simon Warren, Gavin S Wilkie, Maria Zambon, Robin Gopal, Emma C Thomson
BACKGROUND: There are thousands of survivors of the 2014 Ebola outbreak in west Africa. Ebola virus can persist in survivors for months in immune-privileged sites; however, viral relapse causing life-threatening and potentially transmissible disease has not been described. We report a case of late relapse in a patient who had been treated for severe Ebola virus disease with high viral load (peak cycle threshold value 13.2). METHODS: A 39-year-old female nurse from Scotland, who had assisted the humanitarian effort in Sierra Leone, had received intensive supportive treatment and experimental antiviral therapies, and had been discharged with undetectable Ebola virus RNA in peripheral blood...
July 30, 2016: Lancet
Jacob M Vigil, Patrick Coulombe, Joe Alcock, Eric Kruger, Sarah S Stith, Chance Strenth, Mark Parshall, Sara B Cichowski
Ethnic minority patients receive lower priority triage assignments in Veteran's Affairs (VA) emergency departments (EDs) compared to White patients, but it is currently unknown whether this disparity arises from generalized biases across the triage assessment process or from differences in how objective and/or subjective institution-level or person-level information is incorporated into the triage assessment process, thus contributing to disparate treatment.The VA database of electronic medical records of patients who presented to the VA ED from 2008 to 2012 was used to measure patient ethnicity, self-reported pain intensity (PI) levels, heart rate (HR), respiratory rate (RR), and nurse-provided triage assignment, the Emergency Severity Index (ESI) score...
April 2016: Medicine (Baltimore)
Jacob R Worsham, Mark R Elliott, Anthony M Harris
Open calcaneus fractures are usually the result of high-energy mechanisms and are associated with other orthopedic and whole body system injures. Understanding the difference between open versus closed fractures is essential for the provider, and they must be vigilant for the associated injuries that present with this condition. We performed a retrospective medical record review of 62 patients (64 calcaneus fractures) with open calcaneus fractures from January 2003 to January 2013 presenting at a level 1 trauma center...
January 2016: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
Jacob M Vigil, Chance R Strenth, Andrea A Mueller, Jared DiDomenico, Diego Guevara Beltran, Patrick Coulombe, Jane Ellen Smith
This study examines the associations between objective and subjective measurements and impressions of body shape and cold pressor pain reporting in healthy adults. On the basis of sexual selection theory (SST), we hypothesized that body characteristics that are universally preferred by the opposite sex-specifically, lower waist-to-hip ratios (WHR) in women and higher shoulder-to-hip ratios (SHR) in men-and characteristics (e.g., proportion of body fat in women) that infer attractiveness differently across cultures will correspond to higher experimental pain reporting in women and lower pain reporting in males...
June 2015: Human Nature: An Interdisciplinary Biosocial Perspective
Jacob Basilius, Marielle P Young, Timothy C Michaelis, Ronald Hobbs, Glen Jenkins, M Elizabeth Hartnett
IMPORTANCE: This report presents evidence from spectral-domain optical coherence tomography and fluorescein angiography of inner foveal structural abnormalities associated with vision loss in incontinentia pigmenti (IP). OBSERVATIONS: Two children had reduced visual behavior in association with abnormalities of the inner foveal layers on spectral-domain optical coherence tomography. Fluorescein angiography showed filling defects in retinal and choroidal circulations and irregularities of the foveal avascular zones...
September 2015: JAMA Ophthalmology
Jacob M Vigil, Joe Alcock, Patrick Coulombe, Laurie McPherson, Mark Parshall, Allison Murata, Heather Brislen
BACKGROUND: The goal of these analyses was to determine whether there were systematic differences in Emergency Severity Index (ESI) scores, which are intended to determine priority of treatment and anticipate resource needs, across categories of race and ethnicity, after accounting for patient-presenting vital signs and examiner characteristics, and whether these differences varied among male and female Veterans Affairs (VA) ED patients. METHODS AND FINDINGS: We used a large national database of electronic medical records of ED patients from twenty-two U...
2015: PloS One
Rakesh Mohan, Vigil Dev Asir, Shanmugapriyan, Vijay Ebenezr, Abu Dakir, Balakrishnan, Jeffin Jacob
Nitrous oxide (N2O) is the most commonly used inhalation anesthetic in dentistry and is commonly used in emergency centers and ambulatory surgery centers as well. When used alone, it is incapable of producing general anesthesia reliably. However, as a single agent, it has an impressive safety and is excellent for providing minimal and moderate sedation for apprehensive minor oral surgical procedure. In this article, action of N2O in overcoming the anxiety and pain of the patient during the minor oral surgery and its advantages and disadvantages, have been reviewed...
April 2015: Journal of Pharmacy & Bioallied Sciences
Jacob M Vigil, Jared DiDomenico, Chance Strenth, Patrick Coulombe, Eric Kruger, Andrea A Mueller, Diego Guevara Beltran, Ian Adams
Background. Separate lines of research have shown that menstrual cycling and contextual factors such as the gender of research personnel influence experimental pain reporting. Objectives. This study examines how brief, procedural interactions with female and male experimenters can affect experimentally reported pain (cold pressor task, CPT) across the menstrual cycle. Methods. Based on the menstrual calendars 94 naturally cycling women and 38 women using hormonal contraceptives (M age = 19.83,  SD = 3.09) were assigned to low and high fertility groups...
2015: International Journal of Endocrinology
Lauren C Heathcote, Tine Vervoort, Christopher Eccleston, Elaine Fox, Konrad Jacobs, Dimitri M L Van Ryckeghem, Jennifer Y F Lau
This study considered the attentional functioning of adolescents with varying levels of pain catastrophizing. Specifically, we investigated the relationship between pain catastrophizing and attention bias to pain facial expressions. Furthermore, drawing on dual process models in the context of pain, we investigated the moderating role of attention control on this relationship. Adolescents (N = 73; age, 16-18 years) performed a dot-probe task in which facial expressions of pain and neutral expressions were presented for 100 milliseconds and 1250 milliseconds...
July 2015: Pain
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