Michelle S Hamstra, Victoria L Pemberton, Nicholas Dagincourt, Danielle Hollenbeck-Pringle, Felicia L Trachtenberg, James F Cnota, Andrew M Atz, Elizabeth Cappella, Sylvia De Nobele, Josephine Grima, Martha King, Rosalind Korsin, Linda M Lambert, Meghan K MacNeal, Larry W Markham, Gretchen MacCarrick, Donna M Sylvester, Patricia Walter, Mingfen Xu, Ronald V Lacro
BACKGROUND/AIMS: The Pediatric Heart Network Marfan Trial was a randomized trial comparing atenolol versus losartan on aortic root dilation in 608 children and young adults with Marfan syndrome. Barriers to enrollment included a limited pool of eligible participants, restrictive entry criteria, and a diverse age range that required pediatric and adult expertise. Retention was complicated by a 3-year commitment to a complex study and medication regimen. The Network partnered with the Marfan Foundation, bridging the community with the research...
August 21, 2020: Clinical Trials: Journal of the Society for Clinical Trials