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https://www.readbyqxmd.com/read/28938796/complex-interactions-of-circadian-rhythms-eating-behaviors-and-the-gastrointestinal-microbiota-and-their-potential-impact-on-health
#1
Jennifer L Kaczmarek, Sharon V Thompson, Hannah D Holscher
Human health is intricately intertwined with the composition and function of the trillions of microorganisms that make up the gastrointestinal (GI) microbiome. The GI microbiome is essentially a microbial organ that provides metabolic, immunologic, and protective functions for the host. Habitual diet, changes in macronutrient composition, and consumption of nondigestible dietary fibers have all been shown to impact the human GI microbiome. Intriguingly, the impact of diet on the microbiome may be related not only to what humans eat but also to the timing of food consumption...
September 1, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/28938789/impacts-of-dietary-calcium-phytate-and-phytase-on-inositol-hexakisphosphate-degradation-and-inositol-phosphate-release-in-different-segments-of-digestive-tract-of-broilers
#2
W Li, R Angel, S-W Kim, K Brady, S Yu, P W Plumstead
A total of 720 straight-run Heritage 56 M × fast feathering Cobb 500F broiler chickens was fed from 11 to 13 d of age to determine the impacts of dietary calcium (Ca), phytate phosphorus (PP), and phytase concentrations on inositol phosphate (IP3-6) profile in different digestive tract (GI) segments. The experiment was a 2 × 2 × 3 randomized block design with 2 Ca (0.7 and 1.0%) and 2 PP (0.23 and 0.34%) concentrations and 3 doses of Buttiauxella sp. phytase (0, 500, and 1,000 FTU/kg). The experiment was replicated in time (block) with 3 replicates per treatment (Trt) of 10 birds per block...
October 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28938487/regulation-of-endogenous-male-rodent-glp-1-secretion-and-human-islet-insulin-secretion-by-antagonism-of-somatostatin-receptor-5
#3
Thomas B Farb, Marta Adeva, Thomas J Beauchamp, Over Cabrera, David A Coates, Tamika DeShea Meredith, Brian A Droz, Alexander Efanov, James V Ficorilli, Susan L Gackenheimer, Maria A Martinez-Grau, Victoriano Molero, Gema Ruano, Michael A Statnick, Todd M Suter, Samreen K Syed, Miguel A Toledo, Francis S Willard, Xin Zhou, Krister B Bokvist, David G Barrett
Incretin and insulin responses to nutrient loads are suppressed in persons with diabetes, resulting in decreased glycemic control. Whereas agents including sulfonylureas and Dipeptidyl peptidase-4 inhibitors (DPP4i) partially reverse these effects and provide therapeutic benefit, their modes of action limit efficacy. Because somatostatin (SST) has been shown to suppress both insulin and GLP-1 secretion through the Gi-coupled SST receptor 5 (SSTR5) isoform in vitro, antagonism of SSTR5 may improve glycemic control via intervention in both pathways...
September 11, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938449/tsh-igf-1-receptor-cross-talk-rapidly-activates-extracellular-signal-regulated-kinases-in-multiple-cell-types
#4
Christine C Krieger, Joseph D Perry, Sarah J Morgan, George J Kahaly, Marvin C Gershengorn
We previously showed that TSH/IGF-1 receptor cross-talk appears to be involved in Graves' orbitopathy (GO) pathogenesis and up-regulation of thyroid-specific genes in human thyrocytes. In orbital fibroblasts from GO patients (GOFs), co-administration of TSH and IGF-1 induces synergistic increases in hyaluronan secretion. In human thyrocytes, TSH plus IGF-1 synergistically increased expression of sodium-iodide symporter that appeared to involve ERK1/2 activation. However, the details of ERK1/2 activation were not known nor whether ERK1/2 was involved in this synergism in other cell types...
August 11, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938319/review-of-yes-this-is-a-missed-opportunity-let-s-turn-traumatic-injury-into-a-life-saving-event-by-haider-ah-in-ann-surg-265-854-855-2017
#5
Gi J Lim, Larry H Hollier
No abstract text is available yet for this article.
September 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28938238/impact-of-diabetes-mellitus-on-5-year-clinical-outcomes-in-patients-with-chronic-total-occlusion-lesions
#6
Ahmed Mashaly, Seung-Woon Rha, Byoung Geol Choi, Man Jong Baek, Yang Gi Ryu, Se Yeon Choi, Jae Kyeong Byun, Hu Li, Min Suk Shim, Won Young Jang, Woohyeun Kim, Jun Hyuk Kang, Eun Jin Park, Jah Yeon Choi, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh
BACKGROUND: Diabetes mellitus (DM) is a major predictor of cardiovascular morbidity and mortality. However, there are limited data on the impact of DM in patients who have chronic total occlusion (CTO) lesion on long-term outcomes. PATIENTS AND METHODS: A total of 822 CTO patients who underwent coronary angiography, treated by either percutaneous coronary intervention or optimal medical therapy, were enrolled and divided into two groups: (i) diabetic group (n=363) and (ii) nondiabetic group (n=459)...
September 21, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28938202/effect-of-different-diode-laser-wavelengths-on-root-dentin-decontamination-infected-with-enterococcus-faecalis
#7
Caroline Cristina Borges, Carlos Estrela, Fabiane Carneiro Lopes, Regina Guenka Palma-Dibb, Jesus Djalma Pecora, Cyntia Rodrigues De Araújo Estrela, Manoel Damião de Sousa-Neto
The objective of this study was to evaluate the antibacterial effect and the ultrastructural alterations of diode laser with different wavelengths (808nm and 970nm) and its association with irrigating solutions (2.5% sodium hypochlorite and 2% chlorhexidine) in root dentin contaminated by a five days biofilm. Thirteen uniradicular teeth were sectioned into 100 dentin intraradicular blocks. Initially, the blocks were immersed for 5min in 17% EDTA and washed with distilled water for 5min, then samples were sterilized for 30min at 120°C...
September 13, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28937509/non-ige-mediated-gastrointestinal-food-allergies
#8
Priscille Biermé, Anna Nowak-Wegrzyn, Jean-Christoph Caubet
PURPOSE OF REVIEW: We focus on recent advances regarding the epidemiology, physiopathology, diagnosis and managements of non-IgE-mediated gastrointestinal food allergies (non-IgE-GI-FAs), particularly food protein-induced enterocolitis syndrome (FPIES). RECENT FINDINGS: The first international FPIES diagnostic and management guidelines have been recently published. Although FPIES largely remains a diagnosis of exclusion, it may be more prevalent than previously thought...
September 20, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28937388/undiagnosed-senile-systemic-amyloidosis-with-mesenteric-angiopathy-leading-to-fatal-outcomes-two-case-series-with-a-review-of-literature
#9
Avneesh Gupta, Maryna Tarbunova, Anil Aggrawal, Anges E Aysola
Amyloid mesenteric angiopathy is difficult to diagnose as gastrointestinal (GI) signs are nonspecific and radiological studies rarely identify amyloid deposits with certainty. The objective of this study was to highlight the pathological findings of amyloid mesenteric angiopathy in cases of senile systemic amyloidosis. Literature review, author's research data, and practice experience were used. Systemic amyloidosis should be considered in the differential diagnoses when evaluating nonspecific and unexplained GI in patient population aged> 55 years to decrease the morbidity and fatal outcomes...
July 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28937385/primary-classical-hodgkin-lymphoma-of-rectum-report-of-an-extremely-rare-case-and-review-of-the-literature
#10
Jayasudha Arundhathi Vasudevan, Rekha A Nair, K Rakul Nambiar
Hodgkin lymphoma (HL) commonly presents as nodal disease, but in a subset of cases, the disease primarily develops in extranodal sites. Primary classical HL of the gastrointestinal (GI) tract is an extremely rare occurrence. Primary nature of the disease is confirmed after a complete lymphoma work up including chest radiograph, computed tomography scan, peripheral blood, and bone marrow studies. Only a few cases of primary GI lymphomas with limited immunohistochemical or molecular confirmation have been reported in literature...
July 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28937221/in-vivo-dissolution-and-systemic-absorption-of-immediate-release-ibuprofen-in-human-gastrointestinal-tract-under-fed-and-fasted-conditions
#11
Duxin Sun, Jason R Baker, Bo Wen, Ann Frances, Huixia Zhang, Alex Yu, Ting Zhao, Yasuhiro Tsume, Manjunath Pai, Barry Bleske, Xinyuan Zhang, R Lionberger, Allen Lee, Gordon Amidon, William L Hasler, Mark Koenigsknecht
PURPOSE: In vivo drug dissolution in the gastrointestinal (GI) tract is largely unmeasured. The purpose of this clinical study was to evaluate the in vivo drug dissolution and systemic absorption of the BCS Class IIa drug ibuprofen under fed and fasted conditions by direct sampling of stomach and small intestinal luminal content. Expanding current knowledge of drug dissolution in vivo will help to establish physiologically relevant in vitro models predictive of drug dissolution. METHODS: A multi-lumen GI catheter was orally inserted into the GI tract of healthy human subjects...
September 22, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28936943/modulation-of-the-gastrointestinal-microbiome-with-nondigestible-fermentable-carbohydrates-to-improve-human-health
#12
Edward C Deehan, Rebbeca M Duar, Anissa M Armet, Maria Elisa Perez-Muñoz, Mingliang Jin, Jens Walter
There is a clear association between the gastrointestinal (GI) microbiome and the development of chronic noncommunicable diseases, providing a rationale for the development of strategies that target the GI microbiota to improve human health. In this article, we discuss the potential of supplementing the human diet with nondigestible fermentable carbohydrates (NDFCs) to modulate the composition, structure, diversity, and metabolic potential of the GI microbiome in an attempt to prevent or treat human disease...
September 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28936772/proteome-characterization-of-copper-stress-responses-in-the-roots-of-sorghum
#13
Swapan Kumar Roy, Seong-Woo Cho, Soo Jeong Kwon, Abu Hena Mostafa Kamal, Dong-Gi Lee, Kabita Sarker, Moon-Soon Lee, Zhanguo Xin, Sun-Hee Woo
Copper (Cu) is a important micronutrient for plants, but it is extremely toxic to plants at high concentration and can inactivate and disturb protein structures. To explore the Cu stress-induced tolerance mechanism, the present study was conducted on the roots of sorghum seedlings exposed to 50 and 100 µM CuSO4 for 5 days. Accumulation of Cu increased in roots when the seedlings were treated with the highest concentration of Cu(2+) ions (100 μM). Elevated Cu concentration provoked notable reduction of Fe, Zn, Ca, and Mn uptake in the roots of sorghum seedlings...
September 21, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28936625/the-reproducibility-of-4-km-time-trial-tt-performance-following-individualised-sodium-bicarbonate-supplementation-a-randomised-controlled-trial-in-trained-cyclists
#14
Lewis Anthony Gough, Sanjoy Kumar Deb, Andy Sparks, Lars Robert McNaughton
BACKGROUND: Individual time to peak blood bicarbonate (HCO3(-)) has demonstrated good to excellent reproducibility following ingestion of both 0.2 g kg(-1) body mass (BM) and 0.3 g kg(-1) BM sodium bicarbonate (NaHCO3), but the consistency of the time trial (TT) performance response using such an individualised NaHCO3 ingestion strategy remains unknown. This study therefore evaluated the reproducibility of 4-km TT performance following NaHCO3 ingestion individualised to time to peak blood bicarbonate...
September 21, 2017: Sports Medicine—Open
https://www.readbyqxmd.com/read/28936286/the-relationship-of-mandibular-radiomorphometric-indices-to-skeletal-age-chronological-age-and-skeletal-malocclusion-type
#15
Ali Tayebi, Maryam Tofangchiha, Mahsa-Arian Fard, Armin Gosili
BACKGROUND: The present study was performed with the following aims: (1) to assess the relationship between skeletal age, measured using the cervical vertebral maturity (CVM) method, and chronological age; (2) to determine the correlation of skeletal and chronological age to the cortical thickness of the lower border of the mandible using the linear radiomorphometric; and (3) to explore the relationship between these indices and skeletal malocclusion type. MATERIAL AND METHODS: The data were collected from the records of 180 patients, including 57 males (31...
August 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28936110/a-working-paradigm-for-the-treatment-of-obesity-in-gastrointestinal-practice
#16
Andres Acosta, Michael Camilleri
Obesity is a chronic, relapsing, multi-factorial disease characterized by abnormal or excessive adipose tissue accumulation that may impair health and increase disease risks. Despite the ever-increasing prevalence and economic and societal burden, the current approaches to treat obesity are not standardized or generally effective. In this manuscript, we describe a current working paradigm developed by a consensus approach for the multidisciplinary treatment of obesity in the GI practice. Obesity should be managed as a continuum of care focusing on weight loss, weight loss maintenance and prevention of weight regain...
January 2017: Techniques in Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28935827/short-term-dietary-curcumin-supplementation-reduces-gastrointestinal-barrier-damage-and-physiological-strain-responses-during-exertional-heat-stress
#17
Mandy C Szymanski, Trevor L Gillum, Lacey M Gould, David S Morin, Matthew R Kuennen
PURPOSE: This work investigated the effect of 3d of 500mg/d dietary curcumin supplementation on gastrointestinal (GI) barrier damage and systems-physiology responses to exertional heat stress in non-heat acclimated humans. METHODS: Eight participants ran (65%VO2max) for 60min in a Darwin® chamber (37°C/25%RH) two times (Curcumin/Placebo). Intestinal fatty acid binding protein (I-FABP) and associated pro-inflammatory (MCP-1, TNFα, IL-6) and anti-inflammatory (IL-1RA, IL-10) cytokines were assayed from plasma collected before (Pre), after (Post), 1hr (1-Post), and 4hrs after (4-Post) exercise...
September 21, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28935750/complete-genome-sequence-of-a-human-sapovirus-gi-2-variant-isolated-from-a-patient-in-ireland-in-2016
#18
Zhihui Yang, Joanne O'Gorman, Cillian De Gascun, Charlene Bennett, Christopher A Elkins, Michael Kulka, Suzie Coughlan
We report here the first near-complete genome sequence (7,463 nucleotides) of a human sapovirus GI.2 variant from Dublin, Ireland, detected in an adult with gastroenteritis in 2016.
September 21, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28935238/biphasic-aspect-of-sexually-dimorphic-ontogenetic-trajectory-of-gyrification-in-the-ferret-cerebral-cortex
#19
K Sawada, I Aoki
The present study characterized quantitatively sexual dimorphic development of gyrification by MRI-based morphometry. High spatial-resolution 3D MR images (using RARE sequence with short TR and minimum TE setting) were acquired from fixed brain of male and female ferrets at postnatal days (PDs) 4 to 90 using 7-tesla preclinical MRI system. The gyrification index was evaluated either throughout the cerebral cortex (global GI) or in representative primary sulci (sulcal GI). The global GI increased linearly from PD 4, and reached a peak at PD 42, marking 1...
September 18, 2017: Neuroscience
https://www.readbyqxmd.com/read/28934961/area-asymmetry-of-heart-rate-variability-signal
#20
Chang Yan, Peng Li, Lizhen Ji, Lianke Yao, Chandan Karmakar, Changchun Liu
BACKGROUND: Heart rate fluctuates beat-by-beat asymmetrically which is known as heart rate asymmetry (HRA). It is challenging to assess HRA robustly based on short-term heartbeat interval series. METHOD: An area index (AI) was developed that combines the distance and phase angle information of points in the Poincaré plot. To test its performance, the AI was used to classify subjects with: (i) arrhythmia, and (ii) congestive heart failure, from the corresponding healthy controls...
September 21, 2017: Biomedical Engineering Online
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