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https://www.readbyqxmd.com/read/29245080/broadband-19f-tocsy-using-burbop-based-spin-lock
#1
Alexander A Marchione, Elizabeth L Diaz
A train of BURBOP universal rotation pulses has been used to generate a spin lock sufficient to observe TOCSY correlations over a 46 kHz 19F spectral window (i.e. 122 ppm on a 9.4 T spectrometer). This spin lock requires lower RF field (γB1 = 15 kHz), and was employed over a wider spectral window, than previously reported DIPSI-2 spin locks. The BURBOP-based spin lock was effected for 80-160 ms periods with a 2% duty cycle without evidence of harm to the RF coil of the probehead. Spectral separation and full set of correlations were obtained for a mixture of perfluorocarbons...
December 5, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/29244225/combination-of-surface-and-vertical-loop-elements-improves-receive-performance-of-a-human-head-transceiver-array-at-9-4%C3%A2-t
#2
N I Avdievich, I A Giapitzakis, A Pfrommer, T Borbath, A Henning
Ultra-high-field (UHF, ≥7 T) human magnetic resonance imaging (MRI) provides undisputed advantages over low-field MRI (≤3 T), but its development remains challenging because of numerous technical issues, including the low efficiency of transmit (Tx) radiofrequency (RF) coils caused by the increase in tissue power deposition with frequency. Tight-fit human head transceiver (TxRx) arrays improve Tx efficiency in comparison with Tx-only arrays, which are larger in order to fit multi-channel receive (Rx)-only arrays inside...
December 15, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29242501/high-throughput-rna-sequencing-reveals-distinct-gene-signatures-in-active-igg4-related-disease
#3
Brandon W Higgs, Yanying Liu, Jianping Guo, Yinong Sebastian, Chris Morehouse, Wei Zhu, Limin Ren, Mengru Liu, Yan Du, Guangyan Yu, Lingli Dong, Hong Hua, Pan Wei, Yi Wang, Zhengang Wang, Yihong Yao, Zhan-Guo Li
We aimed to characterize the molecular differences and effects from prednisone treatment among IgG4-related disease with salivary gland lesions (RD-SG), without SG lesions (RD-nonSG), and IgG4-related retroperitoneal fibrosis (RF). RNA sequencing was conducted on blood from 25 RD-SG, 11 RD-nonSG, 3 RF and 10 control subjects. Among these, 8 RD-nonSG and 12 RD-SG patients were subjected to treatment with prednisone and/or glucocorticoid-sparing agents. Six RD patients had a longitudinal time point. The mRNA levels of IgG4 and IgE, genes specific for Th2 cells, eosinophils, and neutrophils were over-expressed in RD-SG and RD-nonSG...
December 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29241640/association-of-anti-cyclic-citrullinated-protein-antibodies-erosions-and-rheumatoid-factor-with-disease-activity-and-work-productivity-a-patient-registry-study
#4
Evo Alemao, Zhenchao Guo, Michelle L Frits, Christine K Iannaccone, Nancy A Shadick, Michael E Weinblatt
OBJECTIVES: To evaluate associations between the presence of anti-cyclic citrullinated protein antibodies (anti-CCP) and rheumatoid factor (RF) and other outcomes, including joint erosions and both clinical and economic endpoints, in patients with rheumatoid arthritis (RA). METHODS: Data from the Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study (BRASS), a prospective registry of adult RA patients with established or recent-onset RA, were analyzed...
October 13, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29240181/chirped-pulse-based-broadband-rf-channelization-implemented-by-a-mode-locked-laser-and-dispersion
#5
Wenhui Hao, Yitang Dai, Feifei Yin, Yue Zhou, Jianqiang Li, Jian Dai, Wangzhe Li, Kun Xu
Based on chirped pulses, a wideband radio frequency (RF) channelized receiver that can easily support hundreds of channels is proposed. The mixing chirped pulses and its own delayed copy produces an equivalent RF local oscillation (LO). The LO frequency can be changed by simply setting the delay between the two paths. Channelized receiving of broadband RF signals can be realized by parallel delay line arrays. Meanwhile, the use of in-phase/quadrature demodulation avoids the extra optical or electrical filtering as well as image interference...
December 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/29239758/efficacy-and-safety-comparison-between-different-types-of-novel-design-enhanced-open-irrigated-ablation-catheters-in-creating-cavo-tricuspid-isthmus-block
#6
Rikuta Hamaya, Shinsuke Miyazaki, Takatsugu Kajiyama, Tomonori Watanabe, Shigeki Kusa, Hiroaki Nakamura, Hitoshi Hachiya, Yoshito Iesaka
BACKGROUND: Clinical utility of irrigation-tip ablation catheters for cavo-tricuspid isthmus (CTI) ablation is established. Recently, new-generation enhanced-cooling irrigation-tip catheters were introduced into clinical use. This study compared the performance of different types of novel irrigation-tip catheters in CTI ablation. METHODS: One hundred patients undergoing CTI ablation with novel irrigated-tip catheters were included. Ablation was performed with a power output of 30-35W using either 4-mm flexible tip catheters [FlexAbility (FAs) St...
November 24, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/29239225/ureteroscopic-high-frequency-dusting-utilizing-a-120-watt-holmium-laser
#7
James M Tracey, Galina Gagin, Duncan Morhardt, John M Hollingsworth, Khurshid R Ghani
INTRODUCTION & OBJECTIVE: Recently there has been interest in a dusting technique for lithotripsy during ureteroscopy (URS) utilizing high frequency and low pulse energy (HiFr-LoPE) settings. We assessed a 120 Watt holmium laser that permits high frequency (>50 Hz) dusting. MATERIALS AND METHODS: Consecutive URS cases performed by a single surgeon using the P120H (Lumenis, San Jose, CA) were reviewed. Lithotripsy was performed using HiFr-LoPE settings [50-80 Hz /0...
December 14, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29238384/antiarthritic-activity-of-qi-wu-rheumatism-granule-a-chinese-herbal-compound-on-complete-freund-s-adjuvant-induced-arthritis-in-rats
#8
Qi Xu, Yong Zhou, Rong Zhang, Zhan Sun, Lu-Feng Cheng
Objective: The aim was to study the therapeutic effects and mechanisms of QWRG on adjuvant-induced RA in rats. Methods: The RA rat models were manipulated and subsequently divided into five experimental groups: AIA, DEX, and QWRG groups. The paw volume, body weight, arthritic score, and mechanical nociceptive threshold were assessed. The serum levels of the RF, MDA, ALP, AST, ALT, IL-1β, IL-2, IL-16, and TNF-α were measured. The proliferative capacity of lymphocytes was evaluated, and the synovial tissue was histopathologically examined...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29237074/measurement-and-evaluation-of-electric-field-strength-levels-in-primary-and-secondary-schools-in-a-pilot-region
#9
Cetin Kurnaz, Begum Korunur Engiz, Murat Cem Bozkurt
In this study, in order to evaluate the exposed radiofrequency electromagnetic field (RF-EMF) levels, and to control their compliance with the limits determined by International Commission on Non-Ionizing Radiation Protection (ICNIRP), extensive short-term/band-selective and long-term RF-EMF measurements were conducted at 92 primary and secondary schools in the Ilkadım district of Samsun/Turkey. The measurements were performed once each in May, June, October and December in 2016, using the PMM-8053 EMF meter...
December 11, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29236525/convergence-in-reports-of-adolescents-psychopathology-a-focus-on-disorganized-attachment-and-reflective-functioning
#10
Jessica L Borelli, Alexandra Palmer, Salome Vanwoerden, Carla Sharp
Although convergence in parent-youth reports of adolescent psychopathology is critical for treatment planning, research documents a pervasive lack of agreement in ratings of adolescents' symptoms. Attachment insecurity (particularly disorganized attachment) and impoverished reflective functioning (RF) are 2 theoretically implicated predictors of low convergence that have not been examined in the literature. In a cross-sectional investigation of adolescents receiving inpatient psychiatric treatment, we examined whether disorganized attachment and low (adolescent and parent) RF were associated with patterns of convergence in adolescent internalizing and externalizing symptoms...
December 13, 2017: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/29236504/atomristor-non-volatile-resistance-switching-in-atomic-sheets-of-transition-metal-dichalcogenides
#11
Ruijing Ge, Xiaohan Wu, Myungsoo Kim, Jianping Shi, Sushant Sudam Sonde, Li Tao, Yanfeng Zhang, Jack Lee, Deji Akinwande
Recently, two-dimensional (2D) atomic sheets have inspired new ideas in nanoscience including topologically-protected charge transport, spatially-separated excitons, and strongly anisotropic heat transport. Here, we report the intriguing observation of stable non-volatile resistance switching (NVRS) in single-layer atomic sheets sandwiched between metal electrodes. NVRS is observed in the prototypical semiconducting (MX2, M=Mo, W; and X=S, Se) transitional metal dichalcogenides (TMDs), which alludes to the universality of this phenomenon in TMD monolayers, and offers forming-free switching...
December 13, 2017: Nano Letters
https://www.readbyqxmd.com/read/29236128/nk-and-nkt-like-cells-in-patients-with-recurrent-furunculosis
#12
Danuta Nowicka, Ewelina Grywalska, Elżbieta Fitas, Michał Mielnik, Jacek Roliński
To analyze changes in the number and percentage of NK and NKT-like cells in relation to other immune cells as well as to examine associations between increased susceptibility to infections and NK and NKT-like status in patients with recurrent furunculosis (RF) and healthy controls. Thirty patients with RF and 20 healthy age- and sex-matched volunteers were recruited. Blood samples were examined. Lymphocyte count and cytometric analyses were conducted. For statistical analysis, the Student's t test, F test, and Brown-Forsythe test were used for comparison between groups of variables...
December 13, 2017: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29235041/a-hybrid-constant-and-oscillatory-field-ion-mobility-analyzer-using-structures-for-lossless-ion-manipulations
#13
Aneesh Prabhakaran, Ahmed M Hamid, Sandilya V B Garimella, Blandina R Valenzuela, Robert G Ewing, Yehia M Ibrahim, Richard D Smith
Here we explore the combination of constant and oscillatory fields applied in a single device to affect the continuous separation and filtering of ions based on their mobilities. The device explored allows confining and manipulating ions utilizing a combination of radio frequency (rf), direct current (DC) fields, and traveling waves (TW) in a structures for lossless ion manipulations (SLIM) module. We have investigated theoretically and experimentally a concept for continuous filtering of ions based on their mobilities where ions are mobility separated and selected by passage through two regions, both of which incorporated combined TW and constant fields providing opposing forces on the ions...
December 12, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29233617/efficient-low-power-tobsy-sequences-for-fast-mas
#14
Kong Ooi Tan, Vipin Agarwal, Nils-Alexander Lakomek, Susanne Penzel, Beat H Meier, Matthias Ernst
Through-bond J-coupling based experiments in solid-state NMR spectroscopy are challenging because the J couplings are typically much smaller than the dipolar couplings. This often leads to a lower transfer efficiency compared to dipolar-coupling based sequences. One of the reasons for the low transfer efficiency are the second-order cross terms involving the strong heteronuclear dipolar couplings leading to fast magnetization decay. Here, we show that by employing a symmetry-based C9 sequence, which was carefully selected to suppress second-order terms, efficient polarization transfers of up to 80% can be achieved without decoupling on fully protonated two-spin model systems at a MAS frequency of 55...
December 5, 2017: Solid State Nuclear Magnetic Resonance
https://www.readbyqxmd.com/read/29233242/preflight-in-flight-and-postflight-imaging-of-the-cervical-and-lumbar-spine-in-astronauts
#15
Michael F Harrison, Kathleen M Garcia, Ashot E Sargsyan, Douglas Ebert, Roy F Riascos-Castaneda, Scott A Dulchavsky
BACKGROUND: Back pain is a common complaint during spaceflight that is commonly attributed to intervertebral disc swelling in microgravity. Ultrasound (US) represents the only imaging modality on the International Space Station (ISS) to assess its etiology. The present study investigated: 1) The agreement and correlation of spinal US assessments as compared to results of pre- and postflight MRI studies; and 2) the trend in intervertebral disc characteristics over the course of spaceflight to ISS...
January 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29232397/distribution-and-prevalence-of-vector-borne-diseases-in-california-chipmunks-tamias-spp
#16
Mary H Straub, Austin N Roy, Amanda Martin, Kathleen E Sholty, Nicole Stephenson, Janet E Foley
California, with 13 chipmunk (Tamias) species, has more than any other state or country, occupying habitats ranging from chaparral to the high peaks of the Sierra Nevada. Chipmunks host zoonotic pathogens including Yersinia pestis, Anaplasma phagocytophilum, relapsing fever (RF) Borrelia spp., Borrelia burgdorferi, and spotted fever group (SFG) Rickettsia species. Chipmunk species are often not differentiated by public health workers, yet different species utilize different ecological niches and may have intrinsically different capacities for maintaining vector-borne pathogens and infecting vectors...
2017: PloS One
https://www.readbyqxmd.com/read/29230860/cardiac-gating-using-scattering-of-an-8-channel-parallel-transmit-coil-at-7t
#17
Sven H F Jaeschke, Matthew D Robson, Aaron T Hess
PURPOSE: To establish a cardiac signal from scattering matrix or scattering coefficient measurements made on a 7T 8-channel parallel transmit (pTx) system, and to evaluate its use for cardiac gating. METHODS: Measurements of the scattering matrix and scattering coefficients were acquired using a monitoring pulse sequence and during a standard cine acquisition, respectively. Postprocessing used an independent component analysis and gating feature identification. The effect of the phase of the excitation radiofrequency (RF) field ( B1+ shim) on the cardiac signal was simulated for multiple B1+ shim configurations, and cine images were reconstructed from both the scattering coefficients and electrocardiogram (ECG)...
December 11, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29230647/validating-a-continental-scale-groundwater-diffuse-pollution-model-using-regional-datasets
#18
Issoufou Ouedraogo, Pierre Defourny, Marnik Vanclooster
In this study, we assess the validity of an African-scale groundwater pollution model for nitrates. In a previous study, we identified a statistical continental-scale groundwater pollution model for nitrate. The model was identified using a pan-African meta-analysis of available nitrate groundwater pollution studies. The model was implemented in both Random Forest (RF) and multiple regression formats. For both approaches, we collected as predictors a comprehensive GIS database of 13 spatial attributes, related to land use, soil type, hydrogeology, topography, climatology, region typology, nitrogen fertiliser application rate, and population density...
December 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29228516/refining-prediction-in-treatment-resistant-depression-results-of-machine-learning-analyses-in-the-trd-iii-sample
#19
Alexander Kautzky, Markus Dold, Lucie Bartova, Marie Spies, Thomas Vanicek, Daniel Souery, Stuart Montgomery, Julien Mendlewicz, Joseph Zohar, Chiara Fabbri, Alessandro Serretti, Rupert Lanzenberger, Siegfried Kasper
OBJECTIVE: The study objective was to generate a prediction model for treatment-resistant depression (TRD) using machine learning featuring a large set of 47 clinical and sociodemographic predictors of treatment outcome. METHOD: 552 Patients diagnosed with major depressive disorder (MDD) according to DSM-IV criteria were enrolled between 2011 and 2016. TRD was defined as failure to reach response to antidepressant treatment, characterized by a Montgomery-Asberg Depression Rating Scale (MADRS) score below 22 after at least 2 antidepressant trials of adequate length and dosage were administered...
December 5, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29227127/symptom-and-performance-validity-with-veterans-assessed-for-attention-deficit-hyperactivity-disorder-adhd
#20
Robert D Shura, John H Denning, Holly M Miskey, Jared A Rowland
Little is known about attention-deficit/hyperactivity disorder (ADHD) in veterans. Practice standards recommend the use of both symptom and performance validity measures in any assessment, and there are salient external incentives associated with ADHD evaluation (stimulant medication access and academic accommodations). The purpose of this study was to evaluate symptom and performance validity measures in a clinical sample of veterans presenting for specialty ADHD evaluation. Patients without a history of a neurocognitive disorder and for whom data were available on all measures (n = 114) completed a clinical interview structured on DSM-5 ADHD symptoms, the Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF), and the Test of Memory Malingering Trial 1 (TOMM1) as part of a standardized ADHD diagnostic evaluation...
December 2017: Psychological Assessment
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