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Retinopathy

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https://www.readbyqxmd.com/read/28340314/ocular-manifestations-in-children-with-juvenile-onset-systemic-lupus-erythematosus
#1
Ghada Gawdat, Dina El-Fayoumi, Huda Marzouk, Yomna Farag
PURPOSE: To study the ocular manifestations of juvenile systemic lupus erythematosus (JSLE), including the ocular side-effects of the systemic medications used. METHODS: A descriptive cross-sectional study on 40 children diagnosed with JSLE was conducted. Ophthalmological and laboratory investigations as well as a calculation of the Systemic Lupus Disease Activity Index 2000 (SLEDAI-2K) were performed. RESULTS: Forty consecutive children, 32 females and 8 males, with JSLE were examined...
March 24, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28339607/gross-motor-trajectories-during-the-first-year-of-life-for-preterm-infants-with-very-low-birth-weight
#2
Yu-Han Su, Suh-Fang Jeng, Wu-Shiun Hsieh, Yu-Kang Tu, Yen-Tzu Wu, Li-Chiou Chen
Background.: Early identification of motor dysfunction in very-low-birth-weight (VLBW) preterm infants is important in order to provide early intervention. Objective.: This study was to examine the motor trajectories of VLBW preterm infants during their first year of life and to investigate the predictive ability and influencing factors of the trajectories. Design and Methods.: A total of 342 VLBW preterm infants were prospectively assessed for motor development by the Alberta Infant Motor Scales at 4, 6, 9 and 12 months and for developmental outcomes using the Bayley Scales of Infant and Toddler Development- second edition at 24 months...
February 4, 2017: Physical Therapy
https://www.readbyqxmd.com/read/28339297/long-term-effect-of-panretinal-photocoagulation-on-spectral-domain-optical-coherence-tomography-measurements-in-diabetic-retinopathy
#3
Haeng-Jin Lee, Tae-Seen Kang, Baek-Soo Kwak, Young-Joon Jo, Jung-Yeul Kim
PURPOSE: To evaluate the effects of panretinal photocoagulation on spectral domain optical coherence tomography measurements in diabetic retinopathy by comparing the thicknesses of the central macula, retinal nerve fiber layer, and ganglion cell layer, we used a Cirrus HD OCT® (Carl Zeiss Meditec, Dublin, CA, USA) in normal and diabetic retinopathy cohorts. METHODS: We analyzed patients who visited our retinal clinic between May 2013 and July 2014. The patients were classified into four groups: normal (Group A), diabetes without diabetic retinopathy (Group B), severe nonproliferative or proliferative diabetic retinopathy (Group C), and at least 3 years after panretinal photocoagulation treatment (Group D)...
March 24, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28338667/primary-photodynamic-therapy-with-verteporfin-for-small-pigmented-posterior-pole-choroidal-melanoma
#4
I D Fabian, A W Stacey, V Papastefanou, L Al Harby, A K Arora, M S Sagoo, V M L Cohen
PurposeThe purpose of the study was to investigate the outcomes of primary photodynamic therapy (PDT) for small pigmented posterior pole choroidal melanoma.Patients and methodsProspective interventional consecutive case series of 15 patients with small pigmented posterior pole choroidal melanoma, who were treated with three sessions of PDT and followed-up thereafter. Risk factors for failure were assessed and outcome measures at presentation were compared to those at last follow-up visit.ResultsTumor control was achieved in 12 (80%) patients in a median follow-up time of 15 months (mean 14, range 8-18)...
March 24, 2017: Eye
https://www.readbyqxmd.com/read/28338558/correlation-between-central-foveal-thickness-and-visual-acuity-in-patients-with-idiopathic-vitreomacular-traction
#5
Mehmet M Uzel, Mehmet Citirik, Cagri Ilhan, Kemal Tekin
PURPOSE: To evaluate the impact of preoperative central foveal thickness (CFT) on visual acuity after surgery in patients with idiopathic vitreomacular traction and to calculate a cut-off value in preoperative CFT. METHODS: Thirty-five patients with idiopathic vitreomacular traction were evaluated retrospectively. A complete ophthalmological examination including spectral domain optical coherence tomography was performed preoperatively and at 12 months after the surgery...
March 23, 2017: Retina
https://www.readbyqxmd.com/read/28338557/ruthenium-106-brachytherapy-in-the-treatment-of-circumscribed-choroidal-hemangioma
#6
Masood Naseripour, Arash Maleki, Arezoo Astaraki, Ahad Sedaghat, Ramin Jaberi, Stacey Lee, Zohreh Azma, Sukhum Silpa-Archa
PURPOSE: To examine the efficacy and safety of Ruthenium-106 plaque radiotherapy in the treatment of circumscribed choroidal hemangioma. METHODS: Twenty-one eyes of 21 patients diagnosed with symptomatic circumscribed choroidal hemangioma who underwent Ruthenium-106 plaque radiotherapy were included in the study. Clinical response, ancillary tests finding improvement, and major side effects were evaluated. RESULTS: From the initial to the 1-year follow-up visits, vision improved in 12 eyes (57%), was stable in 7 eyes (33%), and became worse in 2 eyes (10%)...
March 23, 2017: Retina
https://www.readbyqxmd.com/read/28338045/abnormal-levels-of-histone-methylation-in-the-retinas-of-diabetic-rats-are-reversed-by-minocycline-treatment
#7
Wenjun Wang, Simone Sidoli, Wenquan Zhang, Qing Wang, Leilei Wang, Ole N Jensen, Lin Guo, Xiaolu Zhao, Ling Zheng
In this study we quantified the alterations of retinal histone post-translational modifications (PTMs) in diabetic rats using a liquid chromatography - tandem mass spectrometry (LC-MS/MS) approach. Some diabetic rats were subsequently treated with minocycline, a tetracycline antibiotic, which has been shown to inhibit the diabetes-induced chronic inflammation in the retinas of rodents. We quantified 266 differentially modified histone peptides, including 48 out of 83 methylation marks with significantly different abundancein retinas of diabetic rats as compared to non-diabetic controls...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28337877/correlation-between-cystatin-c-and-retinopathy-of-type-two-diabetes-mellitus-patients
#8
C Qian, G M Wan, P S Yan, W Z Wang, S Z Liang, Y Dong
Diabetic retinopathy is one of most common diabetic microvascular complications. In recent years the incidence of the disease has increased, hence early diagnosis and treatment are of great importance. In order to find reliable biological indexes to diagnose and treat type-two diabetes mellitus promptly, this study focused on the correlation between Cystatin C (Cys C) and retinopathy of type-two diabetes mellitus patients. One hundred and eighty type-two diabetes mellitus patients and one hundred healthy controls (the control group) were chosen in this study...
January 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28337343/long-term-outcomes-of-primary-trabeculectomy-in-diabetic-patients-without-retinopathy-with-primary-angle-closure-glaucoma
#9
Jian Liu, Miaomiao Zhang, Bin Li, Jianrong Wang
Purpose. To evaluate primary trabeculectomy with adjunctive mitomycin-C (MMC) in diabetic patients without retinopathy with primary angle-closure glaucoma (PACG). Design. This is a retrospective case series comparison. Participants. This retrospective trial compared outcomes of 88 eyes that underwent trabeculectomy in patients with diabetes mellitus (DM) without retinopathy and in 97 patients without DM. Methods. In this study, the intraocular pressure (IOP), visual acuity, visual field, and postoperative complications were compared between the two groups...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28337307/effects-of-microrna-29a-on-retinopathy-of-prematurity-by-targeting-agt-in-a-mouse-model
#10
Xin-Ke Chen, Li-Juan Ouyang, Zheng-Qin Yin, Yuan-You Xia, Xiu-Rong Chen, Hui Shi, Yan Xiong, Lian-Hong Pi
BACKGROUND: This study aimed to explore the effects of microRNA-29a (miR-29a) on retinopathy of prematurity (ROP) by targeting angiotensinogen (AGT) expression in a mouse model. METHODS: Ninety-six C57BL/6J mice were selected and divided into the normal control group (n = 12) and the oxygen-induced retinopathy (OIR) group (n = 84). All the mice in the OIR group were assigned to the following seven groups (12 mice in each group): the blank, miR-29a mimics, miR-29a inhibitors, empty plasmid, miR-29a mimics + si-AGT, miR-29a inhibitors + si-AGT and si-AGT groups...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28337055/diabetic-retinopathy-knowledge-awareness-and-practices-of-physicians-in-primary-care-centers-in-riyadh-saudi-arabia
#11
Raghad Al Rasheed, Fadwa Al Adel
PURPOSE: Diabetic retinopathy (DR) is a serious cause of irreversible blindness and is the most common complication of diabetes. Annual fundus examination for diabetics aids in the prevention of blindness and allows intervening at a timely manner. As primary care physicians (PCP) are the main providers for diabetic care in Saudi Arabia, we aim to evaluate the current knowledge and awareness, and to assess practices among PCP regarding DR. METHODS: We conducted a cross-sectional study covering 46 randomly selected primary-care centers in Riyadh during October 2015...
January 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28336472/comparison-of-strategies-for-grading-retinal-images-of-premature-infants-for-referral-warranted-retinopathy-of-prematurity
#12
David L Rogers, Don L Bremer, Rae R Fellows, Agnieshka Baumritter, Ebenezer Daniel, Max Pastilli, Gui-Shang Ying, Graham E Quinn
PURPOSE: To determine the accuracy of identifying referral-warranted retinopathy of prematurity (RW-ROP, defined as any zone I ROP, stage 3 or worse, or plus disease) from retinal image sets using three grading protocols: a single optic disk-centered image, a set of 3 horizontal images, and a 5-image set. METHODS: In this secondary analysis of images from the e-ROP study, a weighted sample of 250 image sets from 250 infants (125 with RW-ROP and 125 without RW-ROP) was randomly selected...
March 20, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28336215/association-of-increased-levels-of-mcp-1-and-cathepsin-d-in-young-onset-type-2-diabetes-patients-t2dm-y-with-severity-of-diabetic-retinopathy
#13
Sruthi Reddy, Anandakumar Amutha, Ramachandran Rajalakshmi, Regin Bhaskaran, Finny Monickaraj, Sampathkumar Rangasamy, Ranjit Mohan Anjana, Shiny Abhijit, Kuppan Gokulakrishnan, Arup Das, Viswanathan Mohan, Muthuswamy Balasubramanyam
AIM: Young onset type 2 diabetes patients (T2DM-Y) have been shown to possess an increased risk of developing microvascular complications particularly diabetic retinopathy. However, the molecular mechanisms are not clearly understood. In this study, we investigated the serum levels of monocyte chemotactic protein 1 (MCP-1) and cathepsin-D in patients with T2DM-Y without and with diabetic retinopathy. METHODS: In this case-control study, participants comprised individuals with normal glucose tolerance (NGT=40), patients with type 2 diabetes mellitus (T2DM=35), non-proliferative diabetic retinopathy (NPDR=35) and proliferative diabetic retinopathy (PDR=35)...
March 10, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28336057/hemorrhage-and-or-microaneurysm-severity-and-count-in-ultrawide-field-images-and-early-treatment-diabetic-retinopathy-study-photography
#14
Paolo S Silva, Hala El-Rami, Rasha Barham, Aditi Gupta, Alan Fleming, Jano van Hemert, Jerry D Cavallerano, Jennifer K Sun, Lloyd Paul Aiello
OBJECTIVE: To evaluate detection of hemorrhage and/or microaneurysm (H/Ma) using ultrawide field (UWF) retinal imaging as compared with standard Early Treatment Diabetic Retinopathy Study (ETDRS) 7-field photographs (ETDRS photos). DESIGN: Single-site comparative study of UWF images and ETDRS photos. PARTICIPANTS: One hundred twenty-six eyes of 69 patients with no diabetic retinopathy (DR) or mild or moderate nonproliferative DR (NPDR). METHODS: Stereoscopic 200° UWF images and stereoscopic 35mm 30° 7-field color photographs were acquired on the same visit...
March 20, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28335933/screening-for-diabetic-retinopathy-in-youth-onset-diabetes
#15
EDITORIAL
Emily Y Chew
No abstract text is available yet for this article.
April 2017: Ophthalmology
https://www.readbyqxmd.com/read/28335755/the-incidence-of-diabetes-mellitus-and-diabetic-retinopathy-in-a-population-based-cohort-study-of-people-age-50%C3%A2-years-and-over-in-nakuru-kenya
#16
Andrew Bastawrous, Wanjiku Mathenge, Kevin Wing, Madeleine Bastawrous, Hillary Rono, Helen A Weiss, David Macleod, Allen Foster, Tunde Peto, Peter Blows, Matthew Burton, Hannah Kuper
BACKGROUND: The epidemic rise of diabetes carries major negative public health and economic consequences particularly for low and middle-income countries. The highest predicted percentage growth in diabetes is in the sub-Saharan Africa (SSA) region where to date there has been no data on the incidence of diabetic retinopathy from population-based cohort studies and minimal data on incident diabetes. The primary aims of this study were to estimate the cumulative six-year incidence of Diabetes Mellitus (DM) and DR (Diabetic Retinopathy), respectively, among people aged ≥50 years in Kenya...
March 23, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28335564/passage-through-the-ocular-barriers-and-beneficial-effects-in-retinal-ischemia-of-topical-application-of-pacap1-38-in-rodents
#17
Dora Werling, William A Banks, Therese S Salameh, Timea Kvarik, Laszlo Akos Kovacs, Alexandra Vaczy, Edina Szabo, Flora Mayer, Rita Varga, Andrea Tamas, Gabor Toth, Zsolt Biro, Tamas Atlasz, Dora Reglodi
The neuropeptide pituitary adenylate cyclase activating polypeptide (PACAP) has two active forms, PACAP1-27 and PACAP1-38. Among the well-established actions are PACAP's neurotrophic and neuroprotective effects, which have also been proven in models of different retinopathies. The route of delivery is usually intravitreal in studies proving PACAP's retinoprotective effects. Recently, we have shown that PACAP1-27 delivered as eye drops in benzalkonium-chloride was able to cross the ocular barriers and exert retinoprotection in ischemia...
March 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28335514/the-association-between-vitamin-d-deficiency-and-diabetic-retinopathy-in-type-2-diabetes-a-meta-analysis-of-observational-studies
#18
Bang-An Luo, Fan Gao, Lu-Lu Qin
Emerging evidence from in vivo and in vitro studies have shown that vitamin D may play an important role in the development of diabetic retinopathy (DR), but individually published studies showed inconclusive results. The aim of this study was to quantitatively summarize the association between vitamin D and the risk of diabetic retinopathy. We conducted a systematic literature search of Pubmed, Medline, and EMBASE updated in September 2016 with the following keywords: "vitamin D" or "cholecalciferol" or "25-hydroxyvitamin D" or "25(OH)D" in combination with "diabetic retinopathy" or "DR"...
March 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28334376/author-response-quantitative-retinal-optical-coherence-tomography-angiography-in-patients-with-diabetes-without-diabetic-retinopathy
#19
Galina Dimitrova, Etsuo Chihara, Hirokazu Takahashi, Hiroyuki Amano, Kazushiro Okazaki
No abstract text is available yet for this article.
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28334375/quantitative-retinal-optical-coherence-tomography-angiography-in-patients-with-diabetes-without-diabetic-retinopathy
#20
Fangyao Tang, Carol Y Cheung
No abstract text is available yet for this article.
March 1, 2017: Investigative Ophthalmology & Visual Science
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