Timothy F Huddy, Yang Hsia, Ryan D Kibler, Jinwei Xu, Neville Bethel, Deepesh Nagarajan, Rachel Redler, Philip J Y Leung, Connor Weidle, Alexis Courbet, Erin C Yang, Asim K Bera, Nicolas Coudray, S John Calise, Fatima A Davila-Hernandez, Hannah L Han, Kenneth D Carr, Zhe Li, Ryan McHugh, Gabriella Reggiano, Alex Kang, Banumathi Sankaran, Miles S Dickinson, Brian Coventry, T J Brunette, Yulai Liu, Justas Dauparas, Andrew J Borst, Damian Ekiert, Justin M Kollman, Gira Bhabha, David Baker
A wooden house frame consists of many different lumber pieces, but because of the regularity of these building blocks, the structure can be designed using straightforward geometrical principles. The design of multicomponent protein assemblies, in comparison, has been much more complex, largely owing to the irregular shapes of protein structures1 . Here we describe extendable linear, curved and angled protein building blocks, as well as inter-block interactions, that conform to specified geometric standards; assemblies designed using these blocks inherit their extendability and regular interaction surfaces, enabling them to be expanded or contracted by varying the number of modules, and reinforced with secondary struts...
March 13, 2024: Nature