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https://www.readbyqxmd.com/read/27894216/bone-effects-of-canagliflozin-a-sodium-glucose-co-transporter-2-inhibitor-in-patients-with-type-2-diabetes-mellitus
#1
Thomas C Blevins, Azeez Farooki
Canagliflozin, a sodium glucose co-transporter 2 (SGLT2) inhibitor approved for the treatment of type 2 diabetes mellitus (T2DM), lowers blood glucose by inhibiting renal glucose reabsorption and increasing urinary glucose excretion. It has been reported that SGLT2 inhibitors may have potential adverse effects on bone, including increased fracture risk and decreased bone mineral density (BMD). Across clinical studies, canagliflozin was not associated with meaningful changes in serum or urine calcium, vitamin D, or parathyroid hormone...
November 28, 2016: Postgraduate Medicine
https://www.readbyqxmd.com/read/27869876/-smart-web-support-a-new-tool-to-help-information-sharing-in-managing-complex-paediatric-diseases-study-protocol
#2
Paola Rosati, Armando Grossi, Alessandro Inserra, Graziamaria Ubertini, Giusy Ferro, Barbara Baldini Ferroli, Ludovica Martini, Daniela Cotzia
As devices for learning, smart-web support (SWS) multimedia hypertexts on the web now provide more versatile and interactive reading systems than those traditionally available in static printed texts. Designing similar tools for clinical practice would make complex scientific information easier to comprehend, and present the various therapeutic options to patients as minimally alarming graphical representations. In a pilot project we intend to produce a SWS tool for parents or tutors of children with primary differentiated thyroid cancer (DTC), a heretofore rare disease whose incidence has increased over recent years...
November 2016: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/27859440/peripheral-nerve-ultrasound-in-cerebellar-ataxia-neuropathy-vestibular-areflexia-syndrome-canvas
#3
Luciana Pelosi, Ruth Leadbetter, Eoin Mulroy, Andrew M Chancellor, Stuart Mossman, Richard Roxburgh
INTRODUCTION: We report preliminary findings of nerve ultrasound in patients with cerebellar ataxia neuropathy vestibular areflexia syndrome (CANVAS) who have sensory impairment due to dorsal root ganglionopathy. METHODS: The ultrasound cross-sectional area (CSA) of median and ulnar nerves of 7 CANVAS patients was compared with 7 age- and gender-matched controls and with the mean CSA of our reference population. RESULTS: The nerve CSA of CANVAS patients was significantly smaller than that of controls at all sites (P < 0...
November 15, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27801448/characterization-and-utilization-of-prussian-blue-and-its-pigments
#4
Fernande Grandjean, Louise Samain, Gary J Long
This review deals with our long-range goal of determining why the Prussian blue pigments, typically either the "soluble" KFe(III)[Fe(II)(CN)6]·xH2O or the alternative "insoluble" Fe[Fe(II)(CN)6]3·xH2O compounds, used by artists from shortly after the discovery of Prussian blue in 1704 and well into the early twentieth century, often fade when exposed to light. In order to achieve this goal it was decided that first, for comparison purposes, we had to prepare and fully characterize Prussian blues prepared by various, often commercially successful, synthetic methods...
November 1, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27799428/raman-spectroscopic-analysis-of-a-noli-me-tangere-painting
#5
Stephen Hibberts, Howell G M Edwards, Mona Abdel-Ghani, Peter Vandenabeele
The discovery of an oil painting in seriously damaged condition with an important historical and a heterodox detail with possible origins in the late fifteenth century has afforded the opportunity for Raman microscopic analysis prior to its restoration being undertaken. The painting depicts a risen Christ following His crucifixion in a 'noli me tangere' pose with three women in an Italian terrace garden with a stone balustrade overlooking a rural landscape and an undoubted view of late-medieval Florence. The picture has suffered much abuse and is in very poor condition, which is possibly attributable to its controversial portrayal of a polydactylic Christ with six toes on His right foot...
December 13, 2016: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/27771968/application-of-microemulsions-for-the-removal-of-synthetic-resins-from-paintings-on-canvas
#6
Sara Guizzo, Cristina Tortolini, Federico Pepi, Francesca Leonelli, Franco Mazzei, Francesca Di Turo, Gabriele Favero
Traditional cleaning methods with organic solvents often are not suitable for removal of aged resin so researchers have to find new formulations. In this work, a case study is reported in which new microemulsions were applied on the surface of a painting covered by some aged resin layers used during a previous restoration. Based on the quality of the intervention and the analysis of a sample of the varnish carried out with both MALDI-TOF and ATR-IR spectrometers, it was conjectured that this undesired material could be an acrylic polymer...
October 23, 2016: Natural Product Research
https://www.readbyqxmd.com/read/27766567/ceftaroline-fosamil-a-review-in-complicated-skin-and-soft-tissue-infections-and-community-acquired-pneumonia
#7
Lesley J Scott
Intravenous ceftaroline fosamil (Zinforo™), a prodrug that is rapidly converted to its active metabolite ceftaroline, is approved for use in adults and children (from 2 months of age) with complicated skin and soft tissue infections (cSSTIs) or community-acquired pneumonia (CAP). In several multinational trials, ceftaroline fosamil was an effective and generally well tolerated treatment in adult and paediatric patients with cSSTIs or CAP. In the phase 3 CANVAS trials, ceftaroline fosamil treatment was noninferior to vancomycin plus aztreonam in adults with cSSTIs...
November 2016: Drugs
https://www.readbyqxmd.com/read/27638075/bilateral-vestibulopathy
#8
M Strupp, K Feil, M Dieterich, T Brandt
The leading symptoms of bilateral vestibulopathy (BVP) are postural imbalance and unsteadiness of gait that worsens in darkness and on uneven ground. There are typically no symptoms while sitting or lying under static conditions. A minority of patients also have movement-induced oscillopsia, in particular while walking. The diagnosis of BVP is based on a bilaterally reduced or absent function of the vestibulo-ocular reflex (VOR). This deficit is diagnosed for the high-frequency range of the angular VOR by a bilaterally pathologic bedside head impulse test (HIT) and for the low-frequency range by a bilaterally reduced or absent caloric response...
2016: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27554134/efficacy-and-safety-of-boceprevir-based-triple-therapy-in-hcv-cirrhotic-patients-awaiting-liver-transplantation-anrs-hc29-bocepretransplant
#9
Hélène Fontaine, Marianne Maynard, Cécile Bouix, Maria Patrizia Carrieri, Danielle Botta-Fridlund, Louis D'Alteroche, Filomena Conti, Georges-Philippe Pageaux, Vincent Leroy, Sophie Métivier, Rodolphe Anty, François Durand, Valérie Canva, Antoine Vilotitch, Pascal Lebray, Laurent Alric, Christophe Duvoux, Ventzislava Petrov-Sanchez, Frédérik Beaulieux, Célia Wellems, Christelle Paul, Anne-Marie Roque-Afonso, Bruno Roche, Pierre Pradat, Didier Samuel, Jean-Charles Duclos-Vallée
BACKGROUND AND AIMS: In this French multicentre, open-label study, we analyzed the efficacy, safety and patient-reported outcomes of a boceprevir-based triple therapy in HCV genotype 1 cirrhotic patients awaiting liver transplantation (LT). METHODS: Patients received PEG-IFN/ribavirin (RBV) for 48 weeks (W) and boceprevir from W4 to W48 or until LT. RESULTS: Fifty-one patients (80% males, median age: 56 years) were included. Fifty-seven percent had hepatocellular carcinoma and 43% end-stage liver disease...
August 20, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27512092/towards-a-structure-of-feeling-abjection-and-allegories-of-disease-in-science-fiction-mutation-films
#10
Frances Pheasant-Kelly
This article considers differences between the representation of mutation in science fiction films from the 1950s and the present, and identifies distinctive changes over this time period, both in relation to the narrative causes of genetic disruption and in the aesthetics of its visual display. Discerning an increasingly abject quality to science fiction mutations from the 1970s onwards-as a progressive tendency to view the physically opened body, one that has a seemingly fluid interior-exterior reversal, or one that is almost beyond recognition as humanoid-the article connects a propensity for disgust to the corresponding socio-cultural and political zeitgeist...
August 10, 2016: Medical Humanities
https://www.readbyqxmd.com/read/27453162/chasing-therapeutic-targets-in-thymic-malignancies-finding-needles-in-the-haystack-to-frame-a-comprehensive-canvas
#11
EDITORIAL
Nicolas Girard
No abstract text is available yet for this article.
August 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27450392/valaciclovir-to-prevent-cytomegalovirus-mediated-adverse-modulation-of-the-immune-system-in-anca-associated-vasculitis-canvas-study-protocol-for-a-randomised-controlled-trial
#12
Dimitrios Chanouzas, Lovesh Dyall, Peter Nightingale, Charles Ferro, Paul Moss, Matthew David Morgan, Lorraine Harper
BACKGROUND: The ANCA-associated vasculitides (AAV) are systemic autoimmune inflammatory disorders characterised by necrotising inflammation affecting small to medium-sized blood vessels. Despite improvements in survival, infection and cardiovascular disease remain leading causes of morbidity and mortality. Considerable evidence suggests that CD4 + CD28null T-cell expansions, predominantly seen in Cytomegalovirus (CMV) seropositive individuals, are associated with systemic dysregulation of immune function leading to a heightened risk of infection and cardiovascular disease...
July 22, 2016: Trials
https://www.readbyqxmd.com/read/27417055/disease-specific-sparing-of-the-anterior-semicircular-canals-in-bilateral-vestibulopathy
#13
Alexander A Tarnutzer, Christopher J Bockisch, Elena Buffone, Stefan Weiler, Lucas M Bachmann, Konrad P Weber
OBJECTIVE: Bilateral vestibular loss (BVL) is often diagnosed with great delay and an underlying cause is only identified in 50-80%. We measured horizontal and vertical semicircular canal function using the video-head-impulse test (vHIT) and hypothesized that specific vHIT-patterns may be linked to certain etiologies. METHODS: We retrospectively analyzed 109 BVL-patients linked to aminoglycoside vestibulotoxicity (n=16), Menière's disease (n=10), infectious inner-ear disorders (n=11), sensorineural hearing-loss (n=11), cerebellar-ataxia-neuropathy-vestibular-areflexia-syndrome (CANVAS, n=5), other causes (n=19) as well as those with unknown origin (n=47)...
August 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/27382338/the-treatment-of-type-2-diabetes-in-the-presence-of-renal-impairment-what-we-should-know-about-newer-therapies
#14
REVIEW
Melanie Davies, Sudesna Chatterjee, Kamlesh Khunti
Worldwide, an estimated 200 million people have chronic kidney disease (CKD), the most common causes of which include hypertension, arteriosclerosis, and diabetes. Importantly, ~40% of patients with diabetes develop CKD, yet evidence from major multicenter randomized controlled trials shows that intensive blood glucose control through pharmacological intervention can reduce the incidence and progression of CKD. Standard therapies for the treatment of type 2 diabetes include metformin, sulfonylureas, meglitinides, thiazolidinediones, and insulin...
2016: Clinical Pharmacology: Advances and Applications
https://www.readbyqxmd.com/read/27365894/william-osler-and-seymour-thomas-the-boy-artist-of-texas
#15
Charles S Bryan
Critics consider the 1908-1909 portrait of William Osler by S. Seymour Thomas the best of six oil-on-canvas portraits of Osler done from life, including those by the more acclaimed US artists John Singer Sargent and William Merritt Chase. Osler called it "the best pictorial diagnosis I have ever seen" and told Thomas "I am at your service." A reappraisal of Seymour Thomas explains why his portrait makes us feel much as the artist did in Osler's presence, which is the original English-language definition of "empathy...
July 2016: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/27348742/effect-of-intervertebral-disc-height-on-the-range-of-motion-and-clinical-outcomes-after-single-level-implantation-of-prestige-lp-cervical-disc-prosthesis
#16
Huibo Li, Jigang Lou, Hao Liu, Beiyu Wang
OBJECTIVES: Cervical total disc replacement (TDR) is an emerging technology. Cervical arthroplasty theoretically reduces the risk of adjacent level disc degeneration and segmental instability. However, the factors that influence postoperative range of motion (ROM) and clinical outcomes are not fully understood. The aim of our study was to evaluate the effect of intervertebral disc height on the range of motion and clinical outcomes after single-level implantation of Prestige LP cervical disc prosthesis METHODS: A total of 160 patients with single-level Prestige LP cervical disc prosthesis were evaluated...
September 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27348086/sofosbuvir-based-treatment-of-hepatitis-c-with-severe-fibrosis-metavir-f3-f4-after-liver-transplantation
#17
Jérôme Dumortier, Vincent Leroy, Christophe Duvoux, Victor de Ledinghen, Claire Francoz, Pauline Houssel-Debry, Sylvie Radenne, Louis d'Alteroche, Claire Fougerou-Leurent, Valérie Canva, Vincent di Martino, Filomena Conti, Nassim Kamar, Christophe Moreno, Pascal Lebray, Albert Tran, Camille Besch, Alpha Diallo, Alexandra Rohel, Emilie Rossignol, Armand Abergel, Danielle Botta-Fridlund, Audrey Coilly, Didier Samuel, Jean-Charles Duclos-Vallée, Georges-Philippe Pageaux
Recurrence of hepatitis C virus (HCV) after liver transplantation (LT) can rapidly lead to liver graft cirrhosis and, therefore, graft failure and retransplantation or death. The aim of the present study was to assess efficacy and tolerance of sofosbuvir (SOF)-based regimens for the treatment of HCV recurrence in patients with severe fibrosis after LT. The Compassionate Use of Protease Inhibitors in Viral C Liver Transplantation (CULPIT) study is a prospective multicenter cohort including patients with HCV recurrence following LT treated with second generation direct antivirals...
October 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27322705/machine-learning-approaches-in-maldi-msi-clinical-applications
#18
Manuel Galli, Italo Zoppis, Andrew Smith, Fulvio Magni, Giancarlo Mauri
INTRODUCTION: Despite the unquestionable advantages of Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging in visualizing the spatial distribution and the relative abundance of biomolecules directly on-tissue, the yielded data is complex and high dimensional. Therefore, analysis and interpretation of this huge amount of information is mathematically, statistically and computationally challenging. AREAS COVERED: This article reviews some of the challenges in data elaboration with particular emphasis on machine learning techniques employed in clinical applications, and can be useful in general as an entry point for those who want to study the computational aspects...
July 2016: Expert Review of Proteomics
https://www.readbyqxmd.com/read/27316668/efficacy-and-safety-of-canagliflozin-in-combination-with-insulin-a-double-blind-randomized-placebo-controlled-study-in-japanese-patients-with-type-2-diabetes-mellitus
#19
Nobuya Inagaki, Shin-Ichi Harashima, Nobuko Maruyama, Yutaka Kawaguchi, Maki Goda, Hiroaki Iijima
BACKGROUND: Combination therapy with canagliflozin and insulin was investigated in a prescribed substudy of the canagliflozin Cardiovascular Assessment Study (CANVAS); however, it was not evaluated in Japanese patients with type 2 diabetes mellitus (T2DM). Since the usage profile of insulin therapy and pathologic features of Japanese patients differ from those of Caucasian patients, we determined the clinical benefit of such a combination therapy in Japanese patients. METHODS: Patients who had inadequate glycemic control despite insulin, diet and exercise therapies were randomized into placebo (n = 70) and canagliflozin 100 mg (n = 76) groups that were administered once daily in addition to their prior insulin therapy in this double-blind, placebo-controlled study...
June 18, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27262758/multicentre-experience-using-daclatasvir-and-sofosbuvir-to-treat-hepatitis-c-recurrence-the-anrs-cupilt-study
#20
Audrey Coilly, Claire Fougerou-Leurent, Victor de Ledinghen, Pauline Houssel-Debry, Christophe Duvoux, Vincent Di Martino, Sylvie Radenne, Nassim Kamar, Louis D'Alteroche, Vincent Leroy, Valérie Canva, Pascal Lebray, Christophe Moreno, Jérôme Dumortier, Christine Silvain, Camille Besch, Philippe Perre, Danielle Botta-Fridlund, Rodolphe Anty, Claire Francoz, Armando Abergel, Maryline Debette-Gratien, Filomena Conti, François Habersetzer, Alexandra Rohel, Emilie Rossignol, Hélène Danjou, Anne-Marie Roque-Afonso, Didier Samuel, Jean-Charles Duclos-Vallée, Georges-Philippe Pageaux
BACKGROUND & AIMS: HCV recurrence remains a major issue in the liver transplant field, as it has a negative impact on both graft and patient survival. The purpose of this study was to investigate the efficacy and safety of treating HCV recurrence with sofosbuvir (SOF) and daclatasvir (DCV) combination therapy. METHODS: From October 2013 to March 2015, 559 liver recipients were enrolled in the prospective multicentre France REcherche Nord&Sud Sida-hiv Hépatites (ANRS) Compassionate use of Protease Inhibitors in viral C Liver Transplantation cohort...
October 2016: Journal of Hepatology
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