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https://www.readbyqxmd.com/read/29456602/review-of-management-in-cardiotoxic-overdose-and-efficacy-of-delayed-intralipid-use
#1
Edward Walter, James McKinlay, Jade Corbett, Justin Kirk-Bayley
We present the case of a 51-year-old woman admitted to our intensive care unit following an intentional overdose of a calcium channel antagonist and a beta blocker. The resultant hypotension was reversed with glucagon, noradrenaline, calcium and high-dose insulin. Despite these interventions, she remained vasoplegic and received a delayed, standard dose of intralipid. Subsequently, the vasoplegia resolved rapidly, and the vasopressor was stopped. Here, we review the management of overdose of calcium channel and beta-adrenergic receptor blockers, concentrating on the pharmacology of lipid emulsion therapy...
February 2018: Journal of the Intensive Care Society
https://www.readbyqxmd.com/read/29455465/insulin-like-growth-factor-2-a-poor-prognostic-biomarker-linked-to-racial-disparity-in-women-with-uterine-carcinosarcoma
#2
Anne R Van Arsdale, Rebecca C Arend, Maria J Cossio, Britt K Erickson, Yanhua Wang, David W Doo, Charles A Leath, Gary L Goldberg, Gloria S Huang
The objective of this study was to investigate the relationship of insulin-like growth factor 2 (IGF2) expression and survival in women with uterine carcinosarcoma (UCS). Insulin-like growth factor 2 protein expression was determined by immunohistochemical staining of tumor tissues from 103 patients with UCS. The H-score (product of staining intensity and percentage positive cells) was quantified for the epithelial cytoplasmic (EC), epithelial nuclear (EN), and malignant stromal compartments. Multivariable Cox proportional hazard regression models were used to examine the relationship of IGF2 levels with progression-free survival (PFS) and overall survival (OS)...
February 18, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29455193/growth-trajectory-in-children-with-type-1-diabetes-mellitus-the-impact-of-insulin-treatment-and-metabolic-control
#3
Carla Bizzarri, Tiziana Antonia Timpanaro, Maria Cristina Matteoli, Ippolita Patrizia Patera, Marco Cappa, Stefano Cianfarani
BACKGROUND: Linear growth was reported to be negatively affected by type 1 diabetes mellitus (T1DM), in relation to disease duration and poor metabolic control. It is unclear whether a subtle growth failure still persists despite the optimization of therapy. Our aim was to analyse pubertal growth, adult height, and metabolic profile in a cohort of children with T1DM undergoing intensive insulin treatment by multiple daily injections or continuous subcutaneous insulin infusion (CSII). METHODS: One-hundred and four children (51 males) with prepubertal onset of T1DM were prospectively followed up to final height attainment...
February 16, 2018: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29451226/final-adult-height-and-endocrine-complications-in-young-adults-with-%C3%AE-thalassemia-major-tm-who-received-oral-iron-chelation-oic-in-comparison-with-those-who-did-not-use-oic
#4
Ashraf T Soliman, Mohamed A Yassin, Vincenzo De Sanctis
BACKGROUND: Relatively little is known about endocrine function, bone mineral health, and growth during oral iron chelation therapy in β-thalassemia major patients (TM) on treatment with deferasirox. AIMS OF THE STUDY: To study the frequency of endocrine complications, IGF-1 levels and final adult standing height (FA-Ht) in patients with BTM in two groups of adult patients. PATIENTS AND METHODS: The first group (Group A; 15 patients, 6 females and 9 males) received oral iron chelation therapy (OIC) with deferasirox for 6 years before puberty; the second group (Group B;40 patients) attained the FA-Ht before the use of OIC (iron chelation therapy with deferoxamine (DFO) given subcutaneously, since the age of 2 years)...
February 16, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29446477/atp-sensitive-k-channel-subunits-kir6-1-kir6-2-are-the-candidate-mediators-regulating-ameliorating-effects-of-pulsed-magnetic-field-on-aortic-contractility-in-diabetic-rats
#5
Isil Ocal, Mehmet B Yilmaz, Sabriye Kocaturk-Sel, Turan Tufan, Mehmet A Erkoc, Gamze Comertpay, Hale Oksuz, Esma D Barc
Diabetes mellitus is a metabolic disease that causes increased morbidity and mortality in developed and developing countries. With recent advancements in technology, alternative treatment methods have begun to be investigated in the world. This study aims to evaluate the effect of pulsed magnetic field (PMF) on vascular complications and contractile activities of aortic rings along with Kir6.1 and Kir6.2 subunit expressions of ATP-sensitive potassium channels (K ATP ) in aortas of controlled-diabetic and non-controlled diabetic rats...
February 15, 2018: Bioelectromagnetics
https://www.readbyqxmd.com/read/29433562/the-impact-of-insulin-pump-therapy-to-oxidative-stress-in-patients-with-diabetic-nephropathy
#6
Xing-Guang Zhang, Yan-Qi Zhang, Qian-Peng Cheng, Yi Cao, Jian-Min Sun, Xiao-Feng Lv
BACKGROUND: The oxidative stress resulting from increased production of ROS plays a crucial role in the development of diabetic complications. We aim to explore the relationships between oxidative stress, diabetic nephropathy (DN) and short-term insulin pump intensive therapy (insulin therapy). METHODS: Levels of 8-hydroxy-deoxyguanosine (8-OHdG), 3-nitrotyrosine (3-NT), glutathione (GSH), superoxide dismutase (SOD) and Interleukin-6 (IL-6) were estimated before and after 2 weeks of insulin therapy in normal group (NC) and type 2 diabetic (DM) with normal albuminuria (NA), microalbuminuria (MA) and clinical albuminuria (CA)...
February 12, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/29431405/hyperosmolar-hyperglycemic-state
#7
Gregg D Stoner
Hyperosmolar hyperglycemic state is a life-threatening emergency manifested by marked elevation of blood glucose and hyperosmolarity with little or no ketosis. Although there are multiple precipitating causes, underlying infections are the most common. Other causes include certain medications, nonadherence to therapy, undiagnosed diabetes mellitus, substance abuse, and coexisting disease. In children and adolescents, hyperosmolar hyperglycemic state is often present when type 2 diabetes is diagnosed. Physical findings include profound dehydration and neurologic symptoms ranging from lethargy to coma...
December 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/29429781/high-prevalence-and-incidence-of-diabetic-peripheral-neuropathy-in-children-and-adolescents-with-type-1-diabetes-mellitus-results-from-a-five-year-prospective-cohort-study
#8
Isabella Walter-Höliner, Daniela Seick Barbarini, Jürg Lütschg, Anya Blassnig-Ezeh, Ulrike Zanier, Christoph H Saely, Burkhard Simma
BACKGROUND: In this prospective cohort study, we investigated the prevalence of diabetic peripheral neuropathy at baseline and after five years of follow-up in children and adolescents with type 1 diabetes mellitus using both measurements of nerve conduction velocity and clinical neurological examination. METHODS: A total of 38 patients who underwent insulin pump or intensive insulin therapy were included. The subjects averaged 12.6 ± 2.4 years of age and their diabetes duration averaged 5...
December 13, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/29426748/trends-in-cardiovascular-risk-factor-management-in-type-1-diabetes-by-sex
#9
Krystal K Swasey, Trevor J Orchard, Tina Costacou
AIMS: DCCT showed that intensive type 1 diabetes management reduces complication incidence but did not focus on other cardiovascular disease risk factors, whose control in type 1 diabetes has not been well-studied. We assessed trends in cardiovascular risk factors in type 1 diabetes and attainment of concurrent American Diabetes Association (ADA) guidelines/recommendations (for HbA1c, blood pressure, LDL cholesterol, triglycerides) for complication prevention. METHODS: Individuals with childhood-onset type 1 diabetes (n = 658; 49...
January 10, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29419919/beta-cell-function-after-intensive-subcutaneous-insulin-therapy-or-intravenous-insulin-infusion-at-onset-of-t1d-in-children-without-ketoacidosis
#10
Rebecka Enander, Peter Adolfsson, Torun Bergdahl, Gun Forsander, Johnny Ludvigsson, Ragnar Hanas
BACKGROUND: Our aim was to see if IV insulin therapy at diagnosis preserves beta-cell function better than multiple subcutaneous injections (SC). METHODS: 54 children 9.9±3.5 years (range 2.8-14.9) without ketoacidosis were included in a 2 year, randomized multicenter study with insulin SC or 48-72 hours IV initially. 33 (61%) were boys, 22 (41%) were pubertal. 48 subjects completed 12 months follow-up and 43 completed 24 months. At 1, 6, 12 and 24 months, HbA1c, C-peptide and insulin/kg/24h were measured...
February 8, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29409663/penta-therapy-for-severe-acute-hyperlipidemic-pancreatitis-a-retrospective-chart-review-over-a-10-year-period
#11
Jian Lu, Yun Xie, Jiang Du, Mei Kang, Wei Jin, Yan Li, Hui Xie, Ruijie Cheng, Rui Tian, Ruilan Wang
INTRODUCTION: The purpose of our study is to evaluate the efficacy of penta-therapy for HL-SAP in a retrospective study. METHODS: Retrospective study between January 2007 and December 2016 in a hospital intensive care unit. HL-SAP patients were assigned to conventional treatment alone (the control group) or conventional treatment with the experimental protocol (the penta-therapy group) consists of blood purification, antihyperlipidemic agents, low-molecular weight heparin, insulin, covering the whole abdomen with Pixiao (a traditional Chinese medicine)...
February 3, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29408704/the-effects-of-short-term-continuous-subcutaneous-insulin-infusion-treatment-on-fasting-glucagon-like-peptide-1-concentrations-in-newly-diagnosed-type-2-diabetes
#12
Xiaofei Huang, Sha Li, Mei Yang, Xuquan Fu, Huaqi Li, Tong Yan, Yidong Liu, Lihong Chen, Lingsheng Lan, Libo Li, Xiaowei Zhong
OBJECTIVE: Early short-term intensive insulin therapy in newly diagnosed type 2 diabetes patients shows benefit in glycemic control and β-cell function. Glucagon-like peptide-1 (GLP-1) plays an important role in glucose metabolism and development of type 2 diabetes. We did a study to observe the changes of GLP-1 and β-cell function after short-term continuous subcutaneous insulin infusion (CSII) treatment. METHODS: A total of 66 subjects were enrolled, including 30 normal glucose tolerance controls (NGT) and 36 patients with newly diagnosed type 2 diabetes between October, 2015 and July, 2016...
February 3, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29407057/intensive-diabetes-treatment-and-cardiovascular-outcomes-in-type-1-diabetes-mellitus-implications-of-the-diabetes-control-and-complications-trial-epidemiology-of-diabetes-interventions-and-complications-study-30-year-follow-up
#13
REVIEW
Savitha Subramanian, Irl B Hirsch
Type 1 diabetes mellitus, an autoimmune disorder characterized by beta-cell destruction and absolute insulin deficiency, is associated with significantly increased cardiovascular disease risk but the mechanisms underlying this enhanced risk are unclear. Results of the pivotal Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study have shown that compared to conventional therapy, intensive glycemic control results in decreased cardiovascular morbidity and mortality...
March 2018: Endocrinology and Metabolism Clinics of North America
https://www.readbyqxmd.com/read/29404440/engineered-fgf19-eliminates-bile-acid-toxicity-and-lipotoxicity-leading-to-resolution-of-steatohepatitis-and-fibrosis-in-mice
#14
Mei Zhou, R Marc Learned, Stephen J Rossi, Alex M DePaoli, Hui Tian, Lei Ling
Nonalcoholic fatty liver disease (NAFLD) is an increasingly prevalent chronic liver disease for which no approved therapies are available. Despite intensive research, the cellular mechanisms that mediate NAFLD pathogenesis and progression are poorly understood. Although obesity, diabetes, insulin resistance, and related metabolic syndrome, all consequences of a Western diet lifestyle, are well-recognized risk factors for NAFLD development, dysregulated bile acid metabolism is emerging as a novel mechanism contributing to NAFLD pathogenesis...
December 2017: Hepatology Communications
https://www.readbyqxmd.com/read/29402319/makes-flash-the-difference-between-the-intervention-group-and-the-treatment-as-usual-group-in-an-evaluation-study-of-a-structured-education-and-treatment-programme-for-flash-glucose-monitoring-devices-in-people-with-diabetes-on-intensive-insulin-therapy-study
#15
Melanie Schipfer, Carmen Albrecht, Dominic Ehrmann, Thomas Haak, Bernd Kulzer, Norbert Hermanns
BACKGROUND: People with diabetes on intensive insulin therapy need sufficient glycaemic control to prevent the onset or progression of diabetic complications. The burden of multiple daily blood glucose self-testing can be lessened by novel diabetes technology like flash glucose monitoring systems which provide more information compared to self-monitoring of blood glucose. Despite this delivered additional information studies are showing no significant effect on HbA1c reduction, but a reduced time spent in a hypoglycaemic glucose range...
February 5, 2018: Trials
https://www.readbyqxmd.com/read/29395808/effect-of-short-term-intensive-insulin-therapy-on-the-incretin-response-in-early-type-2-diabetes
#16
H Choi, C K Kramer, B Zinman, P W Connelly, R Retnakaran
AIMS: Short-term intensive insulin therapy (IIT) and gastric bypass surgery are both interventions that can improve beta-cell function, reduce insulin resistance and induce remission of type 2 diabetes. Whereas gastric bypass yields an enhanced glucagon-like peptide-1 (GLP-1) response that may contribute to its metabolic benefits, the effect of short-term IIT on the incretin response is unclear. Thus, we sought to evaluate the impact of IIT on GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) secretion in early type 2 diabetes...
January 11, 2018: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29394488/effect-of-7-days-of-exercise-on-exogenous-carbohydrate-oxidation-and-insulin-resistance-in-children-with-obesity
#17
Lisa Chu, Katherine M Morrison, Michael C Riddell, Sandeep Raha, Brian W Timmons
PURPOSE: The capacity to match carbohydrate (CHO) oxidation with CHO availability (deemed metabolic flexibility (MetFlex)) may be important for type 2 diabetes prevention. In adults, impaired MetFlex is associated with insulin resistance (IR), which can be improved with as little as 7 days of exercise. Whether this occurs similarly in children is unknown. We hypothesized 7 consecutive days of exercise would improve MetFlex and IR in children with obesity. METHODS: Twelve children (8 boys, 4 girls) completed 2 study visits before (PRE) and 2 study visits after (POST) exercise training...
February 2, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29383544/emerging-technologies-for-the-management-of-type-1-diabetes-in-pregnancy
#18
REVIEW
Jennifer M Yamamoto, Helen R Murphy
PURPOSE OF REVIEW: The purpose of the study is to discuss emerging technologies available in the management of type 1 diabetes in pregnancy. RECENT FINDINGS: The latest evidence suggests that continuous glucose monitoring (CGM) should be offered to all women on intensive insulin therapy in early pregnancy. Studies have additionally demonstrated the ability of CGM to help gain insight into specific glucose profiles as they relate to glycaemic targets and pregnancy outcomes...
January 30, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29382312/stem-cells-and-beta-cell-replacement-therapy-a-prospective-health-technology-assessment-study
#19
Klemens Wallner, Rene G Pedroza, Isaac Awotwe, James M Piret, Peter A Senior, A M James Shapiro, Christopher McCabe
BACKGROUND: Although current beta cell replacement therapy is effective in stabilizing glycemic control in highly selected patients with refractory type 1 diabetes, many hurdles are inherent to this and other donor-based transplantation methods. One solution could be moving to stem cell-derived transplant tissue. This study investigates a novel stem cell-derived graft and implant technology and explores the circumstances of its cost-effectiveness compared to intensive insulin therapy...
January 30, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29377408/a-2-year-trial-of-intermittent-insulin-therapy-versus-metformin-for-the-preservation-of-beta-cell-function-after-initial-short-term-intensive-insulin-induction-in-early-type-2-diabetes
#20
Ravi Retnakaran, Haysook Choi, Chang Ye, Caroline K Kramer, Bernard Zinman
AIMS: When administered in early type 2 diabetes (T2DM), short-term intensive insulin therapy (IIT) can improve reversible beta-cell dysfunction and induce subsequent remission of diabetes. However, this remission is ultimately temporary, as beta-cell function deteriorates over time after stopping IIT. Thus, to preserve beta-cell function, we hypothesized that "induction" IIT needs to be followed by a "maintenance therapy." In this context, we sought to evaluate the impact on beta-cell function over 2-years of two approaches to maintenance therapy: intermittent short-term IIT every 3-months versus daily metformin...
January 27, 2018: Diabetes, Obesity & Metabolism
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