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https://www.readbyqxmd.com/read/28641269/a-model-based-tool-for-the-analysis-and-design-of-gene-regulatory-network
#1
Liliana Ironi, Ettore Lanzarone
Computational and mathematical models have significantly contributed to the rapid progress in the study of gene regulatory networks (GRN), but researchers still lack a reliable model-based framework for computer-aided analysis and design. Such tool should both reveal the relation between network structure and dynamics and find parameter values and/or constraints that enable the simulated dynamics to reproduce specific behaviors. This paper addresses these issues and proposes a computational framework that facilitates network analysis or design...
June 19, 2017: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/28641180/potential-chemotherapeutic-effects-of-diosgenin-zoledronic-acid-and-epigallocatechin-3-gallate-on-pe-ca-pj15-oral-squamous-cancer-cell-line
#2
Eduardo Pons-Fuster López, Qin-Tong Wang, Wei Wei, Pia López Jornet
OBJECTIVE: To study the potential chemotherapeutic effects of Diosgenin, zoledronic acid and Epigallocatechin-3-gallate on oral squamous cell cancer (OSCC). MATERIALS AND METHODS: Cell viability, migration, apoptosis and cell cycle evaluation assays were performed in order to assess the effects of different doses of Diosgenin, zoledronic acid and Epigallocatechin-3-gallate on the PE/CA-PJ15 cell line. RESULTS: Doses of 100μM of diosgenin or zoledronic acid reduced cell viability significantly after 72h (p<0...
June 19, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28640774/the-difference-between-countermovement-and-squat-jump-performances-a-review-of-underlying-mechanisms-with-practical-applications
#3
Bas Van Hooren, Julia Zolotarjova
Van Hooren, B and Zolotarjova, J. The difference between countermovement and squat jump performances: a review of underlying mechanisms with practical applications. J Strength Cond Res 31(7): 2011-2020, 2017-Two movements that are widely used to monitor athletic performance are the countermovement jump (CMJ) and squat jump (SJ). Countermovement jump performance is almost always better than SJ performance, and the difference in performance is thought to reflect an effective utilization of the stretch-shortening cycle...
July 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28640656/measuring-exertion-time-duty-cycle-and-hand-activity-level-for-industrial-tasks-using-computer-vision
#4
Oguz Akkas, Cheng Hsien Lee, Yu Hen Hu, Carisa Harris Adamson, David Rempel, Robert G Radwin
Two computer vision algorithms were developed to automatically estimate exertion time, duty cycle (DC), and hand activity level (HAL) from videos of workers performing 50 industrial tasks. The average DC difference between manual frame-by-frame analysis and the computer vision DC was -5.8% for the Decision Tree (DT) algorithm, and 1.4% for the Feature Vector Training (FVT) algorithm. The average HAL difference was 0.5 for the DT algorithm and 0.3 for the FVT algorithm. A sensitivity analysis, conducted to examine the influence that deviations in DC have on HAL, found it remained unaffected when DC error was less than 5%...
June 22, 2017: Ergonomics
https://www.readbyqxmd.com/read/28637157/maximal-and-submaximal-aerobic-tests-for-wheelchair-dependent-persons-with-spinal-cord-injury-a-systematic-review-to-summarize-and-identify-useful-applications-for-clinical-rehabilitation
#5
Sophia Eerden, Rienk Dekker, Florentina J Hettinga
PURPOSE: To summarize the available maximal and submaximal aerobic exercise tests for wheelchair-dependent persons with a spinal cord injury (SCI) and to identify useful applications for clinical rehabilitation. METHOD: The databases of PubMed, CINAHL(®), EMBASE, and PsycINFO(®) were searched for English-language studies published prior to March 2015. Two independent raters identified and examined studies that reported on laboratory-based aerobic exercise tests in persons with an SCI, according to the PRISMA statement...
March 3, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28636819/superelastic-pseudocapacitors-from-freestanding-mno2-decorated-graphene-coated-carbon-nanotube-aerogels
#6
Yepin Zhao, Maxwell Patrick Li, Siyuan Liu, Mohammad F Islam
In recent years, the demand for emerging electronic devices has driven efforts to develop electrochemical capacitors with high power and energy densities that can preserve capacitance under and after recovery from mechanical deformation. We have developed superelastic pseudocapacitors using ≈ 1.5 mm thick graphene-coated single-walled carbon nanotube (SWCNT) aerogels decorated with manganese oxide (MnO2) as freestanding electrodes that retain high volumetric capacitance and electrochemical stability before, under, and after recovery from 50% compression...
June 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28636755/technical-note-combination-of-multiple-epid-imager-layers-improves-image-quality-and-tracking-performance-of-low-contrast-to-noise-objects
#7
Stephen Sf Yip, Joerg Rottmann, Haijian Chen, Daniel Morf, Rony Füglistaller, Josh Star-Lack, George Zentai, Ross Berbeco
PURPOSE: We hypothesized that combining multiple amorphous silicon flat panel layers increases photon detection efficiency in an electronic portal imaging device (EPID), improving image quality and tracking accuracy of low contrast targets during radiotherapy METHODS: The prototype imager evaluated in this study contained 4 individually programmable layers each with a copper converter layer, Gd2 O2 S scintillator and active-matrix flat panel imager (AMFPI). The imager was placed on a Varian TrueBeam linac and a Las Vegas phantom programmed with sinusoidal motion (peak-to-peak amplitude=20mm, Period=3...
June 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/28636053/evidence-of-bad-recycling-practices-bfrs-in-children-s-toys-and-food-contact-articles
#8
A Guzzonato, F Puype, S J Harrad
Brominated flame retardants (BFRs) have been used intentionally in a wide range of plastics, but are now found in an even wider range of such materials (including children's toys and food contact articles) as a result of recycling practices that mix BFR-containing waste plastics with "virgin" materials. In this study Br was quantified in toy and food contact samples on the assumption that its concentration can be used as a metric for BFR contamination. Subsequently, compound specific determination of BFRs was performed to evaluate the validity of the aforementioned assumption, crucial to render rapid, inexpensive, in situ Br determination in non-laboratory environments (such as waste handling facilities) a viable option for sorting wastes according to their BFR content...
June 21, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/28635999/carbon-dots-promoted-vanadium-flow-batteries-for-all-climate-energy-storage
#9
Ying Zhou, Le Liu, Yi Shen, Lantao Wu, Lihong Yu, Feng Liang, Jingyu Xi
We report a one-pot solvothermal method to prepare a carbon dots decorated graphite felt (CDs/GF) electrode. The resulting CDs/GF shows excellent wettability and greatly enhanced activity towards vanadium redox couples. VFB with the CDs/GF electrode exhibits outstanding rate performance, superior cycling stability, and broad temperature adaptability from -20 to 60 °C.
June 21, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28635618/nickel-cobaltite-nanosheets-strongly-anchored-on-boron-and-nitrogen-co-doped-graphene-for-high-performance-asymmetric-supercapacitors
#10
Xinyan Jiao, Xifeng Xia, Peng Liu, Wu Lei, Yu Ouyang, Qingli Hao
Strongly coupled boron and nitrogen co-doped graphene (BN-G) hybrids with nickel cobaltite (NiCo2O4) nanosheets (NCO/BN-G) were fabricated by a facile soft-chemical method for asymmetric supercapacitors with high-performance. The strong interaction between BN-G and NiCo2O4 nanosheets are explored by various techniques. The effect of heteroatom doping on electrochemical properties of the hybrids is systematically investigated. The strong synergistic effect between NiCo2O4 and BN-G leads to a specific capacitance of 106...
June 21, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28635275/infrared-determination-of-the-protonation-state-of-a-key-histidine-residue-in-the-photosynthetic-water-oxidizing-center
#11
Shin Nakamura, Takumi Noguchi
Photosynthetic water oxidation is performed at the Mn4CaO5 cluster in photosystem II (PSII). The protonation structures of amino acid residues and water molecules around the Mn4CaO5 cluster are crucial in water oxidation reactions. In this study, we determined the protonation state of a key His residue in water oxidation, D1-H337, which is directly hydrogen bonded with the oxygen atom of the Mn4CaO5 cluster, using polarized attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy. Flash-induced polarized ATR-FTIR difference spectra upon the S1→S2 transition of oriented PSII membranes showed broad negative and positive features around 2600 and 2900 cm-1, respectively, with large dichroic ratios, accompanied with several minor peaks attributable to the Fermi resonance of a His NH vibration...
June 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28635236/-efficacy-and-safety-of-xiaoaiping-combined-with-chemotherapy-in-the-treatment-of-advanced-esophageal-cancer
#12
F Wang, Q X Fan, H H Wang, D M Han, N S Song, H Lu
Objective: To evaluate the efficacy and safety of Xiaoaiping combined with chemotherapy in the treatment of advanced esophageal cancer. Methods: This is a multi-center, randomized, open label and parallel controlled study. A total of 124 advanced esophageal cancer patients with Karnofsky Performance Status (KPS) score ≥60 and expected survival time≥3 months were enrolled. We adopted design and divided the patients into study and control group. The patients in study group received Xiaoaiping combined with S-1 and cisplatin...
June 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28635185/antipulverization-electrode-based-on-low-carbon-triple-shelled-superstructures-for-lithium-ion-batteries
#13
Lianhai Zu, Qingmei Su, Feng Zhu, Bingjie Chen, Huanhuan Lu, Chengxin Peng, Ting He, Gaohui Du, Pengfei He, Kai Chen, Shihe Yang, Jinhu Yang, Huisheng Peng
The realization of antipulverization electrode structures, especially using low-carbon-content anode materials, is crucial for developing high-energy and long-life lithium-ion batteries (LIBs); however, this technology remains challenging. This study shows that SnO2 triple-shelled hollow superstructures (TSHSs) with a low carbon content (4.83%) constructed by layer-by-layer assembly of various nanostructure units can withstand a huge volume expansion of ≈231.8% and deliver a high reversible capacity of 1099 mAh g(-1) even after 1450 cycles...
June 21, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28635138/snake-spectacle-vessel-permeability-to-sodium-fluorescein
#14
Roy W Bellhorn, Ann R Strom, Monica J Motta, John Doval, Michelle G Hawkins, Joanne Paul-Murphy
OBJECTIVE: Assess vascular permeability of the snake spectacle to sodium fluorescein during resting and shedding phases of the ecdysis cycle. ANIMAL STUDIED: Ball python (Python regius). PROCEDURES: The snake was anesthetized, and spectral domain optic coherence tomography was performed prior to angiographic procedures. An electronically controlled digital single-lens reflex camera with a dual-head flash equipped with filters suitable for fluorescein angiography was used to make images...
June 20, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28634911/novel-insights-into-a-reputably-irreversible-process-combined-mrna-and-mirna-profiling-of-tissue-from-vesicourethral-anastomotic-stenosis-after-radical-prostatectomy
#15
T S Worst, K Daskalova, A Steidler, K Berner-Leischner, R Röth, B Niesler, C-A Weis, M C Kriegmair, P Erben, D Pfalzgraf
PURPOSE: Until recently, tissue fibrosis-ultimately leading to permanent scaring-has been considered an irreversible process. However, recent findings indicate that it may be reversible after all. Vesicourethral anastomotic stenosis (VUAS) as fibrous narrowing is a frequent complication after radical prostatectomy with high recurrence rates and requires invasive treatment. The pathophysiology is poorly understood. Therefore, a combined mRNA and miRNA transcription profiling in tissue from VUAS was performed using nCounter technology...
June 20, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28634818/sg2na-is-a-regulator-of-endoplasmic-reticulum-er-homeostasis-as-its-depletion-leads-to-er-stress
#16
Buddhi Prakash Jain, Shweta Pandey, Nikhat Saleem, Goutam K Tanti, Shalini Mishra, Shyamal K Goswami
SG2NA belongs to a three-member striatin subfamily of WD40 repeat superfamily of proteins. It has multiple protein-protein interaction domains involved in assembling supramolecular signaling complexes. Earlier, we had demonstrated that there are at least five variants of SG2NA generated by alternative splicing, intron retention, and RNA editing. Such versatile and dynamic mode of regulation implicates it in tissue development. In order to shed light on its role in cell physiology, total proteome analysis was performed in NIH3T3 cells depleted of 78 kDa SG2NA, the only isoform expressing therein...
June 21, 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/28634743/comminuted-olecranon-fractures-biomechanical-testing-of-locked-versus-minifragment-non-locked-plate-fixation
#17
David S Wellman, Scott M Tucker, Josh R Baxter, Nadine C Pardee, Lionel E Lazaro, Christopher S Smith, Dean G Lorich, David L Helfet
INTRODUCTION: Open reduction and internal fixation has long been accepted as optimal treatment for displaced olecranon fractures based on poor results seen with conservative management. With the presence of comminution, tension-band wiring constructs are contraindicated due to tendency to compress through fragments, thereby shortening the articular segment. Therefore, plate fixation is typically employed. Our hypothesis was that in a comminuted fracture model, 2.7 mm reconstruction plating without locking screws will perform equally to 3...
June 20, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28634622/burned-out-seminoma-revealed-by-solitary-rib-bone-metastasis
#18
Toshihiko Nishisho, Mika Sakaki, Ryo Miyagi, Shoichiro Takao, Koichi Sairyo
Burned-out tumor is a rare phenomenon in which a testicular tumor regresses in the primary lesion and progresses in a metastatic lesion. We report the case of a 30-year-old male with burned-out seminoma revealed by open biopsy of solitary 10th rib bone metastasis. He underwent inguinal orchiectomy, which revealed hyalinization, indicating a spontaneously regressed testicular tumor. Chemotherapy for seminoma was administered in three cycles of bleomycin + etoposide + cisplatin therapy. The chemotherapy was effective, and wide resection of the rib was subsequently performed...
June 21, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28634390/increased-glutamate-in-somatosensory-cortex-in-functional-dyspepsia
#19
Arthur D P Mak, Georg Northoff, David K W Yeung, Winnie C W Chu, Steve C N Hui, Cynthia Cheung, Jessica Ching, Linda Lam, Sing Lee, Justin Wu
Functional Dyspepsia-Post-prandial Distress Syndrome (FD-PDS) was associated with mood-related increases in resting activity and lowered activation threshold in the somatosensory cortex (SSC), insula and perigenual anterior cingulate cortex(pgACC) in functional imaging studies. The underlying cortical neurochemical changes are unknown. We performed proton Magnetic Resonance Spectroscopy (1H-MRS) on 17 consecutive tertiary clinic-recruited psychotropic-naïve Rome III FD-PDS female and 17 age-sex matched healthy controls...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28634000/dose-dependent-effects-of-abobotulinumtoxina-dysport%C3%A2-on-spasticity-and-active-movements-in-adults-with-upper-limb-spasticity-secondary-analysis-of-a-phase-3-study
#20
Michael W O'Dell, Allison Brashear, Robert Jech, Thierry Lejeune, Philippe Marque, Djamel Bensmail, Ziyad Ayyoub, David M Simpson, Magali Volteau, Claire Vilain, Philippe Picaut, Jean Michel Gracies
BACKGROUND: AbobotulinumtoxinA has beneficial effects on spasticity and active movements in hemiparetic adults with upper limb spasticity (ULS). However, evidence-based information on optimal dosing for clinical use is limited. OBJECTIVE: To describe joint-specific dose effects of abobotulinumtoxinA in adults with ULS. DESIGN: Secondary analysis of a phase 3 study (NCT01313299). SETTING: Multi-center, international, double-blind, placebo-controlled clinical trial...
June 17, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
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