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https://www.readbyqxmd.com/read/27915346/mir-181a-targets-phlpp2-to-augment-akt-signaling-and-regulate-proliferation-and-apoptosis-in-human-keloid-fibroblasts
#1
Zhen Rang, Zong-Yang Wang, Qiu-Yu Pang, You-Wei Wang, Ge Yang, Fan Cui
BACKGROUND/AIMS: Keloids are fibrous overgrowths induced by cutaneous injury. MicroRNAs (miRNAs) have recently emerged as post-transcriptional gene repressors and participants in a diverse array of pathophysiological processes leading to skin disease. The purpose of the current study was to explore the precise functions of miR-181a in human keloid development and the underlying mechanisms. METHODS: A miRNA microarray analysis was performed to compare expression profiles between keloid and normal skin tissues...
December 5, 2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27915342/in-vitro-effects-of-has-2-gene-silencing-on-the-proliferation-and-apoptosis-of-the-mcf-7-human-breast-cancer-cell-line
#2
Hong-Yan Zhang, Feng Liang, Fei Wang, Jian-Wei Zhang, Li Wang, Xi-Gang Kang, Jie Wang, Qi-Liu Duan
BACKGROUND: Breast cancer is characterized by a distinct metastatic pattern involving the regional lymph nodes, bone marrow, lung and liver. This study is aimed to investigate the effects of silencing the HAS-2 gene on the proliferation and apoptosis of human breast cancer cells. METHODS: MCF-7 cells were collected and assigned into control, scrambled siRNA and HAS-2- siRNA groups. After transfection, the morphological changes in the MCF-7 cells were observed using phase contrast microscopy...
December 5, 2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27915168/interactions-of-long-chain-homologues-of-colchicine-with-tubulin
#3
Ana Marzo-Mas, Pascale Barbier, Gilles Breuzard, Diane Allegro, Eva Falomir, Juan Murga, Miguel Carda, Vincent Peyrot, J Alberto Marco
Several colchicine analogues in which the N-acetyl residue has been replaced by aliphatic, straight-chain acyl moieties, have been synthesized. These compounds show high cytotoxic activity at the nanomolar level against the tumoral cell lines HT-29, MCF-7 and A549. Some of them exhibit activities in the picomolar range against the HT-29 line and are thus two to three orders of magnitude more cytotoxic than colchicine. In this specific cell line, the activities were found to be closely related to the length of the acyl carbon chain, an increase in the latter giving rise to an increase in the cytotoxicity with a maximum in the range of 10-12 carbon atoms, followed by a decrease in activity with still longer chains...
November 23, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27915152/goal-equivalent-manifold-analysis-of-task-performance-in-non-specific-lbp-and-healthy-subjects-during-repetitive-trunk-movement-effect-of-load-velocity-symmetry
#4
Mahshid Chehrehrazi, Mohammad Ali Sanjari, Hamid Reza Mokhtarinia, Ali Ashraf Jamshidi, Nader Maroufi, Mohamad Parnianpour
Motor abundance allows reliability of motor performance despite its variability. The nature of this variability provides important information on the flexibility of control strategies. This feature of control may be affected by low back pain (LPB) and trunk flexion/extension conditions. Goal equivalent manifold (GEM) analysis was used to quantify the ability to exploit motor abundance during repeated trunk flexion/extension in healthy individuals and people with chronic non-specific LBP (CNSLBP). Kinematic data were collected from 22 healthy volunteers and 22 CNSLBP patients during metronomically timed, repeated trunk flexion/extension in three conditions of symmetry, velocity, and loading; each at two levels...
December 1, 2016: Human Movement Science
https://www.readbyqxmd.com/read/27914554/comparative-performance-of-ampflstr%C3%A2-identifiler%C3%A2-plus-pcr-amplification-kit-and-qiagen%C3%A2-investigator%C3%A2-idplex-plus-kit
#5
Dalad Mattayat, Thitika Kitpipit, Sukanya Phetpeng, Watee Asawutmangkul, Phuvadol Thanakiatkrai
Many forensic STR kits are currently available in the market. The AmpFLSTR® Identifiler® Plus kit, which targets 15 STRs, is commonly used worldwide. The Thai forensic DNA community is built around it in terms of instrument, databases, and interpretation. QIAGEN's IDplex Plus kit targets the same loci, but the PCR cycling time is shorter by about 90min. A direct comparison that assesses forensic parameters and applicability to casework between the two kits has never been carried out. In this study, we performed a direct comparison between the two kits using serial dilutions of two control DNA samples and 60 randomly selected casework samples, including samples taken from improvised explosive devices and terrorist raids...
December 2016: Science & Justice: Journal of the Forensic Science Society
https://www.readbyqxmd.com/read/27914416/pitch-priming-in-sequences-of-two-sounds
#6
Laurent Demany, Tom Lucas, Catherine Semal
Frequency discrimination limens (FDLs) were measured for pairs of stimuli differing from each other with respect to pitch salience. One of the two stimuli to be compared within a trial was a pure tone of at least 100 ms, evoking a salient pitch, while the other stimulus consisted of only eight sinusoidal cycles (experiment 1), or was a noise band with a Gaussian spectral envelope, evoking a weak pitch corresponding to the peak frequency (experiment 2). From trial to trial, frequency was varied randomly and widely...
September 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27914310/electrical-potentials-measured-on-the-surface-of-the-knee-reflect-the-changes-of-the-contact-force-in-the-knee-joint-produced-by-postural-sway
#7
Lin Zhu, Martin Garon, Éric Quenneville, Michael D Buschmann, Pierre Savard
Electroarthrography (EAG) is a novel technique for recording potentials on the knee surface that are generated by the compression of articular cartilage and that reflect both compression force and cartilage quality. The mechanical loading of the knee is achieved by transferring the subject's body weight from a bipedal stance to a unipedal stance. We hypothesized that EAG potentials change with postural sway. The study was performed on 20 normal subjects (10 male, 10 female; age 29±10.5 yrs.; mass 68.8±14...
October 18, 2016: Gait & Posture
https://www.readbyqxmd.com/read/27914243/efficacy-and-safety-of-bevacizumab-containing-neoadjuvant-therapy-followed-by-interval-debulking-surgery-in-advanced-ovarian-cancer-results-from-the-anthalya-trial
#8
Roman Rouzier, Sébastien Gouy, Frédéric Selle, Eric Lambaudie, Anne Floquet, Virginie Fourchotte, Christophe Pomel, Pierre-Emmanuel Colombo, Elsa Kalbacher, Sandrine Martin-Francoise, Raffaele Fauvet, Philippe Follana, Anne Lesoin, Fabrice Lecuru, Youssef Ghazi, Julien Dupin, Elisabeth Chereau, Sarah Zohar, Paul Cottu, Florence Joly
AIM: To investigate whether adding bevacizumab to neoadjuvant carboplatin-paclitaxel (CP) helps achieve optimal debulking, measured by complete resection rate (CRR) at interval debulking surgery (IDS), in patients with initially unresectable International Federation of Gynecology and Obstetrics stage IIIC/IV ovarian, tubal or peritoneal adenocarcinoma. METHODS: Multicentre, open-label, non-comparative phase II study. Ninety-five patients randomised (2:1) to receive four cycles of neoadjuvant CP ±3 concomitant cycles of bevacizumab 15 mg/kg (BCP) followed by IDS...
November 30, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27914174/mathematical-detection-of-aortic-valve-opening-b-point-in-impedance-cardiography-a-comparison-of-three-popular-algorithms
#9
Javier Rodríguez Árbol, Pandelis Perakakis, Alba Garrido, José Luis Mata, M Carmen Fernández-Santaella, Jaime Vila
The preejection period (PEP) is an index of left ventricle contractility widely used in psychophysiological research. Its computation requires detecting the moment when the aortic valve opens, which coincides with the B point in the first derivative of impedance cardiogram (ICG). Although this operation has been traditionally made via visual inspection, several algorithms based on derivative calculations have been developed to enable an automatic performance of the task. However, despite their popularity, data about their empirical validation are not always available...
December 3, 2016: Psychophysiology
https://www.readbyqxmd.com/read/27914154/short-and-long-term-efficacy-of-laparoscopic-ovarian-diathermy-in-women-with-polycystic-ovary-syndrome
#10
Rita Luz, Joana Barros, Ana Aguiar, Cátia Rodrigues, Ana Paula Soares, Joaquim Nunes, Sandra Sousa, Carlos Calhaz-Jorge
INTRODUCTION: Polycystic ovary syndrome is the most frequent cause of anovulatory infertility and management involves a multistep approach. Laparoscopic ovarian diathermy is accepted as a second-line treatment of patients who failed to respond to clomiphene citrate. The aims of this study were to determine the efficacy of this technique at short and long-term and to perform an analysis of predictive factors of spontaneous pregnancy. MATERIAL AND METHODS: This retrospective study involved 76 women who underwent laparoscopic ovarian diathermy between 2004 and 2013 in a university hospital...
August 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/27913948/branched-chain-amino-acids-administration-suppresses-endurance-exercise-related-activation-of-ubiquitin-proteasome-signaling-in-trained-human-skeletal-muscle
#11
Evgeny A Lysenko, Tatiana F Vepkhvadze, Egor M Lednev, Olga L Vinogradova, Daniil V Popov
We tested whether post exercise ingestion of branched-chain amino acids (BCAA < 10 g) is sufficient to activate signaling associated with muscle protein synthesis and suppress exercise-induced activation of mechanisms associated with proteolysis in endurance-trained human skeletal muscle. Nine endurance-trained athletes performed a cycling bout with and without BCAA ingestion (0.1 g/kg). Post exercise ACC(Ser79/222) phosphorylation (endogenous marker of AMPK activity) was increased (~3-fold, P < 0...
December 3, 2016: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/27913557/translation-and-validation-of-the-cancer-related-fatigue-scale-in-greek-in-a-sample-of-patients-with-advanced-prostate-cancer
#12
Andreas Charalambous, Charis Kaite, Marianna Constantinou, Christiana Kouta
OBJECTIVE: To translate and validate the Cancer-Related Fatigue (CRF) Scale in the Greek language. DESIGN: A cross-sectional descriptive design was used in order to translate and validate the CRF Scale in Greek. Factor analyses were performed to understand the psychometric properties of the scale and to establish construct, criterion and convergent validity. SETTING: Outpatients' oncology clinics of two public hospitals in Cyprus. PARTICIPANTS: 148 patients with advanced prostate cancer undergoing chemotherapy...
December 2, 2016: BMJ Open
https://www.readbyqxmd.com/read/27913497/response-adapted-frontline-therapy-for-hodgkin-lymphoma-are-we-there-yet
#13
Peter W M Johnson
Treating Hodgkin lymphoma by using chemotherapy with or without radiotherapy is highly successful, with substantially fewer deaths from lymphoma than from other causes in recent studies of both early-stage and advanced-stage disease. Long-term toxicity is a major consideration in this context, and recent trials have used functional imaging with [(18)F]fluorodeoxyglucose (FDG) positron emission tomography early in the course of treatment (interim PET) to assess response and modulate subsequent therapy. In early-stage disease, this has allowed omission of consolidation radiotherapy after a good response to doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) chemotherapy, and trials have shown that this can be done without detriment to overall survival, despite a small increase in rates of recurrence of ∼5%...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27913338/intracardiac-vortex-dynamics-by-high-frame-rate-doppler-vortography-i-in-vivo-i-comparison-with-vector-flow-mapping-and-4-d-flow-mri
#14
Julia Faurie, Mathilde Baudet, Kondo Claude Assi, Dominique Auger, Guillaume Gilbert, Francois Tournoux, Damien Garcia
Recent studies have suggested that intracardiac vortex flow imaging could be of clinical interest to early diagnose the diastolic heart function. Doppler vortography has been intro-duced as a simple color Doppler method to detect and quantify intraventricular vortices. This method is able to locate a vortex core based on the recognition of an antisymmetric pattern in the Doppler velocity field. Because the heart is a fast-moving organ, high frame rates are needed to decipher the whole blood vortex dynamics during diastole...
November 29, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/27912124/highly-dispersed-ultrasmall-ni-oh-2-aggregated-particles-on-a-conductive-support-as-a-supercapacitor-electrode-with-superior-performance
#15
Yue Wang, Xianfeng Zhang, Xin Li, Xiaojun Li, Yong Zhao, Hang Wei, Yongguang Liu, Peng Jiang, Minghui Liang
To reduce the size of Ni(OH)2 aggregates is an effective way to improve their capacitive performance for the electrodes of supercapacitors. The ultrasmall Ni(OH)2 aggregates (1-2nm) on active carbon (AC) can be obtained by depositing the soluble precursor of Ni(OH)2 on AC at low temperature. The Ni(OH)2/AC samples were characterized by SEM, TEM, XRD and XPS. The specific capacitance of ultrasmall Ni(OH)2 aggregates in the Ni(OH)2/AC composite can reach 2949Fg(-1) at a scan rate of 20mVs(-1), which is higher than its theoretical specific capacitance (2382Fg(-1))...
November 21, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27910600/development-of-a-neural-network-technique-for-kstar-thomson-scattering-diagnostics
#16
Seung Hun Lee, J H Lee, I Yamada, Jae Sun Park
Neural networks provide powerful approaches of dealing with nonlinear data and have been successfully applied to fusion plasma diagnostics and control systems. Controlling tokamak plasmas in real time is essential to measure the plasma parameters in situ. However, the χ(2) method traditionally used in Thomson scattering diagnostics hampers real-time measurement due to the complexity of the calculations involved. In this study, we applied a neural network approach to Thomson scattering diagnostics in order to calculate the electron temperature, comparing the results to those obtained with the χ(2) method...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910220/inverse-vulcanization-of-sulfur-with-natural-dienes-as-sustainable-materials-for-lithium-sulfur-batteries
#17
David Mecerreyes, Iñaki Gomez, Alberto Blazquez, Olatz Leonet
Lithium sufur batteries are among the most promising next generation battery systems due to the high capacity properties of sulfur as cathodic material. Beyond its interesting intrinsic properties, sulfur possesses a very low conductivity and complex electrochemistry which involves the high solubility of the lithium sulfides in the electrolyte. These two characteristics trigger a series of limitations on its performance as active cathode material which leads to batteries with low cyclability. Recently, inverse vulcanizated sulfur has shown to retain capacity far better than elemental sulfur leading to batteries with excellent cyclability...
December 2, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27909718/enzalutamide-inhibits-proliferation-of-gemcitabine-resistant-bladder-cancer-cells-with-increased-androgen-receptor-expression
#18
Koji Kameyama, Kengo Horie, Kosuke Mizutani, Taku Kato, Yasunori Fujita, Kyojiro Kawakami, Toshio Kojima, Tatsuhiko Miyazaki, Takashi Deguchi, Masafumi Ito
Advanced bladder cancer is treated mainly with gemcitabine and cisplatin, but most patients eventually become resistance. Androgen receptor (AR) signaling has been implicated in bladder cancer as well as other types of cancer including prostate cancer. In this study, we investigated the expression and role of AR in gemcitabine-resistant bladder cancer cells and also the potential of enzalutamide, an AR inhibitor, as a therapeutic for the chemoresistance. First of all, we established gemcitabine-resistant T24 cells (T24GR) from T24 bladder cancer cells and performed gene expression profiling...
November 24, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27909618/clinico-pathological-outcomes-of-post-primary-and-salvage-chemotherapy-retroperitoneal-lymph-node-dissection-for-mixed-germ-cell-tumors-king-hussein-cancer-center-experience
#19
Kholoud Alqasem, Ibrahim Abukhiran, Judy Jasser, Tamer Bisharat, Riyad T Ellati, Jakub Khzouz, Ibrahim Al-Saidi, Ali Al-Daghamin
OBJECTIVE: We sought to characterize clinical and pathologic outcomes of advanced mixed germ cell tumors after retroperitoneal lymph node dissection for post-chemotherapy residual masses. MATERIAL AND METHODS: Between January 2006 and November 2015, 56 patients underwent retroperitoneal lymph node dissection (RPLND) for residual masses of greater than 1 cm after receiving either primary chemotherapy or salvage chemotherapy. Retrospective review of the patients' characteristics, clinical, pathological, and treatment outcomes were performed after institutional review board (IRB) and ethics committee approval...
December 2016: Turkish Journal of Urology
https://www.readbyqxmd.com/read/27909575/a-step-by-step-workflow-for-low-level-analysis-of-single-cell-rna-seq-data
#20
Aaron T L Lun, Davis J McCarthy, John C Marioni
Single-cell RNA sequencing (scRNA-seq) is widely used to profile the transcriptome of individual cells. This provides biological resolution that cannot be matched by bulk RNA sequencing, at the cost of increased technical noise and data complexity. The differences between scRNA-seq and bulk RNA-seq data mean that the analysis of the former cannot be performed by recycling bioinformatics pipelines for the latter. Rather, dedicated single-cell methods are required at various steps to exploit the cellular resolution while accounting for technical noise...
2016: F1000Research
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