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https://www.readbyqxmd.com/read/28735524/characterization-of-cytoskeleton-features-and-maturation-status-of-cultured-human-ipsc-derived-cardiomyocytes
#1
Christian Zuppinger, George Gibbons, Priyanka Dutta-Passecker, Adrian Segiser, Henriette Most, Thomas M Suter
Recent innovations in stem cell technologies and the availability of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have opened new possibilities for studies and drug testing on human cardiomyocytes in vitro. Still, there are concerns about the precise nature of such 'reprogrammed' cells. We have performed an investigation using immunocytochemistry and confocal microscopy on several cellular features using commercially available hiPSC-CMs. For some selected developmentally regulated or cardiac chamber-specific proteins, we have compared the results from hiPSC-derived cardiomyocytes with freshly isolated, ventricular cardiomyocytes from adult rats...
June 21, 2017: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/28735427/biomechanical-evaluation-of-distal-biceps-tendon-repair-using-tension-slide-technique-and-knotless-fixation-technique
#2
David D Savin, Hristo Piponov, Jonathan N Watson, Ari R Youderian, Farid Amirouche, Giovanni F Solitro, Mark R Hutchinson, Benjamin A Goldberg
BACKGROUND: Acute distal biceps tendon ruptures are uncommon injuries that often affect young active males, typically resulting from an eccentric load on their dominant extremity. The purpose of this study was to compare pullout strength and tendon gapping in the tension slide technique (TST) versus a knotless fixation technique (KFT). METHODS: Two sets of experiments were performed using cadaveric elbow specimens. In the first experiment, eight elbows from different cadavers were tested to compare TST with a standard locking whipstitch with KFT, four elbows in each group, using a standard locking whipstitch...
July 22, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28735386/the-performance-and-microbial-communities-of-biodegradation-electron-transfer-with-sulfur-metabolism-integrated-process-for-flue-gas-desulfurization-wastewater-treatment
#3
Chao Wei, Wenjie He, Li Wei, Jun Ma, Chunying Li
The biodegradation-electron transfer with sulfur metabolism integrated (BESI(®)) process was used for the treatment of real flue gas desulfurization wastewater. The BESI(®) process consists of an anaerobic activated sludge reactor, an anoxic activated sludge reactor, and an aerobic bio-film reactor. The performance of the integrated process was evaluated by the removal efficiencies of organics and nitrogen pollutants. The sulfate in the wastewater was used as an abundant sulfur source to drive the integrated process...
July 22, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/28735199/one-pot-synthesis-of-bismuth-silicate-heterostructures-with-tunable-morphology-and-excellent-visible-light-photodegradation-performances
#4
Kun-Le Jia, Jin Qu, Shu-Meng Hao, Fei An, Ya-Qiong Jing, Zhong-Zhen Yu
Construction of a heterostructure to prolong the life of electron-hole pairs is a very important approach to endow it with excellent photodegradation performances. Particularly, one-pot synthesis of heterostructures with the same component but different crystal structures to form a proper band gap is still challenging. Herein, bismuth silicate (BSO) heterostructures are synthesized using a one-pot hydrothermal approach without adding any other inorganic components. The crystal phase, morphology, surface state, and photochemical properties of the BSO materials are precisely tuned to fabricate two kinds of bismuth silicate heterostructures: rod-like Bi2SiO5/Bi12SiO20 and flower-like Bi2SiO5/Bi4Si3O12 heterostructures...
July 15, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28735074/increased-ventilation-in-female-erythropoietin-deficient-mouse-line-is-not-progesterone-and-estrous-stage-dependent
#5
Florine Jeton, Jorge Soliz, Dominique Marchant, Vincent Joseph, Jean-Paul Richalet, Aurélien Pichon, Nicolas Voituron
Previous studies suggest that chronic erythropoietin (Epo) deficiency in male mice does not alter normoxic/hypoxic ventilation. As effects of Epo are sex specific and as progesterone could be a respiratory stimulant, we evaluated the impact of Epo deficiency and its possible interaction with progesterone in ventilatory control in female mice during estrous cycle phases. Compared to wild type (WT) animals, Epo-TAg(h) female mice exhibited higher ventilation in hypoxia. However, when data were separated into luteal and follicular phases of the estrous cycle, basal ventilation and hypoxic ventilation were not different in both mice strains...
July 19, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28734997/influence-of-preparation-fitting-and-cementation-on-the-vitro-performance-and-fracture-resistance-of-cad-cam-crowns
#6
Martin Rosentritt, Verena Preis, Michael Behr, Sebastian Hahnel
OBJECTIVES: To investigate debonding and stability of CAD/CAM composite crowns as a function of (a) preparation design, (b) fitting parameters of the milling process, and (c) type of cementation. METHODS: Extracted human molars were prepared providing either retentive design (R) or no retention (NR). After digitalization, full-contour crowns were milled using either optimal (OF) or reduced (RF) fitting parameters. A total of 112 crowns were milled from the composite materials Lava Ultimate (L) and Grandio Blocs (G) and a ceramic reference...
July 19, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28734607/impact-of-instrument-and-column-parameters-on-high-throughput-liquid-chromatography-performance
#7
Martin Gilar, Thomas S McDonald, Fabrice Gritti
The speed and separation performance of high-throughput liquid chromatography (HT LC) was investigated. We evaluated the contributions of various experimental parameters to the total analysis cycle time, including column length (column void time), gradient delay, flow rate, auto-sampler (A/S) speed, and software related delays. The best case injection-to-injection cycle time of 22s was achieved using 12s gradient time and 2.1×20mm columns packed with 1.7μm C18 particles. The total 22s analytical duty cycle consisted of 2...
July 11, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28734600/tracking-amazonian-cheese-microbial-diversity-development-of-an-original-sustainable-and-robust-starter-by-freeze-drying-spray-drying
#8
A A Ferreira, S Huang, Í T Perrone, P Schuck, G Jan, A F Carvalho
The Marajó cheese made with raw buffalo milk in the Amazon region of Brazil can be considered a good source of wild lactic acid bacteria strains with unexplored and promising characteristics. The aim of this study was to develop a potential probiotic starter culture for industrial applications using freeze drying and spray drying. A decrease in the survival rates of freeze-dried samples compared with spray-dried samples was noted. The spray-dried cultures remained approximately 10(9) cfu·g(-1), whereas the freeze-dried samples showed 10(7) cfu·g(-1) after 60 d of storage at 4°C...
July 19, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28734504/-relationship-between-family-variables-and-conjugal-adjustment
#9
Nerea Jiménez-Picón, Joaquín-Salvador Lima-Rodríguez, Marta Lima-Serrano
OBJECTIVE: To determine whether family variables, such as type of relationship, years of marriage, existence of offspring, number of members of family, stage of family life cycle, transition between stages, perceived social support, and/or stressful life events are related to conjugal adjustment. DESIGN: A cross-sectional and correlational study using questionnaires. LOCATION: Primary care and hospital units of selected centres in the province of Seville, Spain...
July 19, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28734365/automatic-feed-phase-identification-in-multivariate-bioprocess-profiles-by-sequential-binary-classification
#10
Ramin Nikzad-Langerodi, Edwin Lughofer, Susanne Saminger-Platz, Thomas Zahel, Patrick Sagmeister, Christoph Herwig
In this paper, we propose a new strategy for retrospective identification of feed phases from online sensor-data enriched feed profiles of an Escherichia Coli (E. coli) fed-batch fermentation process. In contrast to conventional (static), data-driven multi-class machine learning (ML), we exploit process knowledge in order to constrain our classification system yielding more parsimonious models compared to static ML approaches. In particular, we enforce unidirectionality on a set of binary, multivariate classifiers trained to discriminate between adjacent feed phases by linking the classifiers through a one-way switch...
August 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28734050/estimating-synchronous-demographic-changes-across-populations-using-habc-and-its-application-for-a-herpetological-community-from-northeastern-brazil
#11
Marcelo Gehara, Adrian Antonio Garda, Fernanda P Werneck, Eliana F Oliveira, Emanuel Masiero da Fonseca, Felipe Camurugi, Felipe M de Magalhães, Flávia Mol Lanna, Jack W Sites, Ricardo Marques, Ricardo Silveira-Filho, Vinícius A São Pedro, Guarino R Colli, Gabriel C Costa, Frank T Burbrink
Many studies propose that Quaternary climatic cycles contracted and /or expanded the ranges of species and biomes. Strong expansion-contraction dynamics of biomes presume concerted demographic changes of associated fauna. The analysis of temporal concordance of demographic changes can be used to test the influence of Quaternary climate on diversification processes. Hierarchical approximate Bayesian computation (hABC) is a powerful and flexible approach that models genetic data from multiple species, and can be used to estimate the temporal concordance of demographic processes...
July 22, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28733983/population-pharmacokinetics-and-exposure-response-of-trastuzumab-emtansine-in-advanced-breast-cancer-previously-treated-with-%C3%A2-2-her2-targeted-regimens
#12
Shang-Chiung Chen, Angelica Quartino, Daniel Polhamus, Matthew Riggs, Jonathan French, Xin Wang, Shweta Vadhavkar, Melanie Smitt, Silke Hoersch, Alexander Strasak, Jin Yan Jin, Sandhya Girish, Chunze Li
AIMS: We conducted population pharmacokinetic (PopPK) and exposure-response analyses for trastuzumab emtansine (T-DM1) to assess the need for T-DM1 dose optimization in patients with low exposure by using TH3RESA study data (NCT01419197). The randomized phase III TH3RESA study investigated T-DM1 vs. treatment of physician's choice (TPC) in patients with heavily pretreated HER2-positive advanced breast cancer. METHODS: We compared a historical T-DM1 PopPK model with T-DM1 pharmacokinetics in TH3RESA and performed exposure-response analyses using model-predicted cycle 1 Cmax , cycle 1 Cmin , and AUCss ...
July 21, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28733968/on-the-nature-of-mass-spectrometer-analyzer-contamination
#13
Yang Kang, Bradley B Schneider, Thomas R Covey
Sample throughput in electrospray ionization mass spectrometry (ESI-MS) is limited by the need for frequent ion path cleaning to remove accumulated debris that can lead to charging and general performance degradation. Contamination of ion optics within the vacuum system is particularly problematic as routine cleaning requires additional time for cycling the vacuum pumps. Differential mobility spectrometry (DMS) can select targeted ion species for transmission, thereby reducing the total number of charged particles entering the vacuum system...
July 21, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28733950/tendon-end-separation-with-loading-in-an-achilles-tendon-repair-model-comparison-of-non-absorbable-vs-absorbable-sutures
#14
Michael R Carmont, Jan Herman Kuiper, Karin Grävare Silbernagel, Jón Karlsson, Katarina Nilsson-Helander
BACKGROUND: Rupture of the Achilles tendon often leads to long-term morbidity, particularly calf weakness associated with tendon elongation. Operative repair of Achilles tendon ruptures leads to reduced tendon elongation. Tendon lengthening is a key problem in the restoration of function following Achilles tendon rupture. A study was performed to determine differences in initial separation, strength and failure characteristics of differing sutures and numbers of core strands in a percutaneous Achilles tendon repair model in response to initial loading...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28733872/metabolic-profiles-of-flooding-tolerant-mechanism-in-early-stage-soybean-responding-to-initial-stress
#15
Xin Wang, Wei Zhu, Akiko Hashiguchi, Minoru Nishimura, Jingkui Tian, Setsuko Komatsu
Metabolomic analysis of flooding-tolerant mutant and abscisic acid-treated soybeans suggests that accumulated fructose might play a role in initial flooding tolerance through regulation of hexokinase and phosphofructokinase. Soybean is sensitive to flooding stress, which markedly reduces plant growth. To explore the mechanism underlying initial-flooding tolerance in soybean, mass spectrometry-based metabolomic analysis was performed using flooding-tolerant mutant and abscisic-acid treated soybeans. Among the commonly-identified metabolites in both flooding-tolerant materials, metabolites involved in carbohydrate and organic acid displayed same profile at initial-flooding stress...
July 21, 2017: Plant Molecular Biology
https://www.readbyqxmd.com/read/28733866/inhibitory-effect-and-mechanism-of-mesenchymal-stem-cells-on-melanoma-cells
#16
J Zhang, L Hou, D Zhao, M Pan, Z Wang, H Hu, J He
PURPOSE: To explore the inhibitory effect and mechanism of MSCs on melanoma proliferation. METHODS: The inhibitory effect of MSCs on melanoma A375 cells was detected by co-culture and conditioned medium (CM) experiments using MTT method. The cell cycle was analyzed by flow cytometry. Then, Western Blot experiment detected the expression of proteins related to NF-κB signaling in A375 cells. The expression of IL-1Ra in MSCs was proved by RT-PCR. The over-expression and silencing vector pcDNA3...
July 21, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28733351/multi-cellular-transcriptional-analysis-of-mammalian-heart-regeneration
#17
Gregory A Quaife-Ryan, Choon Boon Sim, Mark Ziemann, Antony Kaspi, Haloom Rafehi, Mirana Ramialison, Assam El-Osta, James E Hudson, Enzo R Porrello
Background -The inability of the adult mammalian heart to regenerate following injury represents a major barrier in cardiovascular medicine. In contrast, the neonatal mammalian heart retains a transient capacity for regeneration, which is lost shortly after birth. Defining the molecular mechanisms that govern regenerative capacity in the neonatal period remains a central goal in cardiac biology. Here, we assemble a transcriptomic framework of multiple cardiac cell populations during postnatal development and following injury, which enables comparative analyses of the regenerative (neonatal) versus non-regenerative (adult) state for the first time...
July 21, 2017: Circulation
https://www.readbyqxmd.com/read/28733011/rapid-preparation-of-high-electrochemical-performance-lifepo4-c-composite-cathode-material-with-an-ultrasonic-intensified-micro-impinging-jetting-reactor
#18
Bin Dong, Xiani Huang, Xiaogang Yang, Guang Li, Lan Xia, George Chen
A joint chemical reactor system referred to as an ultrasonic-intensified micro-impinging jetting reactor (UIJR), which possesses the feature of fast micro-mixing, was proposed and has been employed for rapid preparation of FePO4 particles that are amalgamated by nanoscale primary crystals. As one of the important precursors for the fabrication of lithium iron phosphate cathode, the properties of FePO4 nano particles significantly affect the performance of the lithium iron phosphate cathode. Thus, the effects of joint use of impinging stream and ultrasonic irradiation on the formation of mesoporous structure of FePO4 nano precursor particles and the electrochemical properties of amalgamated LiFePO4/C have been investigated...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28732980/synthesis-of-amine-modified-zeolitic-imidazolate-framework-8-ultrasound-assisted-dye-removal-and-modeling
#19
Jafar Abdi, Manouchehr Vossoughi, Niyaz Mohammad Mahmoodi, Iran Alemzadeh
The present research is focused on the ultrasound assisted adsorption of Acid blue 92 (AB92) and Direct red 80 (DR80) as anionic dyes in single and binary systems onto zeolitic imidazolate framework (ZIF-8) functionalized with 3-Aminopropyltrimethoxysilane (APTES). Different techniques such as Fourier transform infrared (FTIR), scanning electron microscope (SEM), field emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET) and thermogravimetric analyses (TGA) were used to characterize the prepared adsorbent...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28732932/ultrasound-assisted-synthesis-of-performic-acid-in-a-continuous-flow-microstructured-reactor
#20
P D Jolhe, B A Bhanvase, V S Patil, S H Sonawane, I Potoroko
The present work establishes in depth study of ultrasound assisted preparation of performic acid (PFA) in a continuous flow microstructured reactor. The influence of various parameters viz. formic acid: hydrogen peroxide molar ratio, flow rate, temperature and catalyst loading on the PFA formation were studied in a continuous flow microstructured reactor. In a continuous microstructured reactor in the presence of ultrasonic irradiation, the formation of PFA was found to be dependent on the molar ratio of formic acid: hydrogen peroxide, flow rate of reactants, temperature and catalyst loading (Amberlite IR-120H)...
November 2017: Ultrasonics Sonochemistry
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